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Conserved domains on  [gi|161078633|ref|NP_001097922|]
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isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma, isoform B [Drosophila melanogaster]

Protein Classification

NAD-dependent isocitrate dehydrogenase( domain architecture ID 10015520)

NAD-dependent isocitrate dehydrogenase converts isocitrate to 2-oxoglutarate in an NAD-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 55-386 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


:

Pssm-ID: 272942  Cd Length: 333  Bit Score: 587.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633   55 GGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIDPSTEGN-DDLDYAITSIKRNGVALKGNIETKSQSLTEVS 133
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKtEIPDEAVESIKRNKVALKGPLETPIGKGGHRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  134 RNVAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQ 213
Cdd:TIGR00175  81 LNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  214 NNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGG 293
Cdd:TIGR00175 161 NGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  294 AGLISGRNYGDHYAIFEPGTRNTGTAIAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVNDAIRTPDIGGTN 373
Cdd:TIGR00175 241 PGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGTA 320

                         330
                  ....*....|...
gi 161078633  374 SSTDVVENILKIL 386
Cdd:TIGR00175 321 TTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 55-386 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 587.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633   55 GGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIDPSTEGN-DDLDYAITSIKRNGVALKGNIETKSQSLTEVS 133
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKtEIPDEAVESIKRNKVALKGPLETPIGKGGHRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  134 RNVAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQ 213
Cdd:TIGR00175  81 LNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  214 NNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGG 293
Cdd:TIGR00175 161 NGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  294 AGLISGRNYGDHYAIFEPGTRNTGTAIAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVNDAIRTPDIGGTN 373
Cdd:TIGR00175 241 PGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGTA 320

                         330
                  ....*....|...
gi 161078633  374 SSTDVVENILKIL 386
Cdd:TIGR00175 321 TTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 33-386 4.71e-118

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 347.62  E-value: 4.71e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  33 VAHTKSALQKKVTGTDIPSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIdpSTEGNDDLDYAITSIK 112
Cdd:PLN00123   6 LSNALGSKAQRRSVTYMPRPGDGAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEV--HGDMKKVPEEVLESIR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 113 RNGVALKGNIETKSQSLTEvSRNVAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESM 192
Cdd:PLN00123  84 RNKVCLKGGLATPVGGGVS-SLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 193 KVVTVENAERVARYAFEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDV 272
Cdd:PLN00123 163 KVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDV 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 273 MNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHYAIFEPGTR--NTGT-AIAGKNIANPVAMISASIDMLNHLGHKEHAN 349
Cdd:PLN00123 243 MVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASagNVGNeKLVEQKKANPVALLLSSAMMLRHLQFPSFAD 322

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 161078633 350 VIQEAVYQTIVNDAIRTPDIGGTNSSTDVVENILKIL 386
Cdd:PLN00123 323 RLETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANL 359
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 57-386 1.62e-103

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 310.02  E-value: 1.62e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  57 RHAVTMLPGGGIGPELMGYVREIF----RYCGAPIDFEVIDI---------DPSTEgnDDLDyaitSIKRNGVALKGNIE 123
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLeaaaERFGLDFEFEEADIggaaydktgTPLPD--ETLE----ALRKADAILLGAVG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 124 TKS--QSLTEVSRNVAIRNELDLYVNVVHCKSYPGIPARHH-----DIDVVLIRQNTDGEYAMLEHESVPG----IVESM 192
Cdd:COG0473   75 GPKwdDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLKpeiveGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 193 KVVTVENAERVARYAFEFARQNnRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDV 272
Cdd:COG0473  155 RVYTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 273 MNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHY-AIFEPGtrnTGTA--IAGKNIANPVAMISASIDMLNHLGHKEHAN 349
Cdd:COG0473  234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPV---HGSApdIAGKGIANPIATILSAAMMLRHLGEEEAAD 310

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 161078633 350 VIQEAVYQTIvNDAIRTPDIGGTNSSTDVVENILKIL 386
Cdd:COG0473  311 AIEAAVEKVL-AEGVRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
60-382 1.73e-78

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 246.05  E-value: 1.73e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633   60 VTMLPGGGIGPELMGYVREIFRYC----GAPIDFEVIDIDPST--EGNDDL-DYAITSIKRNGVALKGNIETKSQSLTEV 132
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAAlekaPLEFEFEERDVGGAAidETGEPLpDETLEACKKADAVLLGAVGGPKWDPAGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  133 -SRN--VAIRNELDLYVNVVHCKSYPGI----PARHH--DIDVVLIRQNTDGEYAMLEHESVPGIVE---SMKVVTVENA 200
Cdd:pfam00180  82 rPENglLALRKELGLFANLRPAKVFPPLgdasPLKNEveGVDIVIVRELTGGIYFGIEKGIKGSGNEvavDTKLYSRDEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  201 ERVARYAFEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYG 280
Cdd:pfam00180 162 ERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  281 TIVSNVLCGLMGGAGLISGRNYGDH-YAIFEPgTRNTGTAIAGKNIANPVAMISASIDMLNH-LGHKEHANVIQEAVYQT 358
Cdd:pfam00180 242 DILSDEASMLTGSLGLLPSASLGANgFGIFEP-VHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320

                         330       340
                  ....*....|....*....|....*..
gi 161078633  359 IvNDAIRTPDIGGTN---SSTDVVENI 382
Cdd:pfam00180 321 L-ESGIRTGDLAGSAtyvSTSEFGEAV 346
iso_homocit_dh NF040855
isocitrate--homoisocitrate dehydrogenase;
60-383 7.21e-35

isocitrate--homoisocitrate dehydrogenase;


Pssm-ID: 468794  Cd Length: 345  Bit Score: 131.84  E-value: 7.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  60 VTMLPGGGIGPELM-----------GYVR--------EIFRYCGAPIDfevididpstegNDDLDyaitSIKRNGVALKG 120
Cdd:NF040855   4 VAVIKGDGIGPEVIdaairvvnavtDRIRfyefeggfEVFKRYGSPIR------------EEDLE----EIRKMDAVLFG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 121 NIETKSQSLTEVSRNVAIRNELDLYVNVVHcksypgIPARHHDIDVVLIRQNTDGEYAMLehesvpGIVESMKVV----- 195
Cdd:NF040855  68 ATTTPFDVPGYKSLIITLRKELDLYANLRI------IPDLWNGREIVIVRENSEGLYSGL------GAVFSDRAVdfrii 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 196 TVENAERVARYAFEFARQNNrKKVTTIHKANIMKlSDGLF----LEVANRvhkdyPELEHNNMIIDNTCMQSVSNPHQFD 271
Cdd:NF040855 136 TREGAERIARFAVNLAKERG-SFITFVHKANVLT-GDKFFrkivLEIAER-----EGVEVREAIVDSFTIKLVRNPWNHG 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 272 VMNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHYAIFEPgTRNTGTAIAGKNIANPVAMISASIDMLNHLGHkeHANVI 351
Cdd:NF040855 209 VILSENLFGDILSDLATIHAGSIGIVPSGNYGDDIALFEP-IHGSAPDIAGKGIANPIGAILSAAMMLDYLGL--DGSII 285

                        330       340       350
                 ....*....|....*....|....*....|..
gi 161078633 352 QEAVYQTIVNDAIrTPDIGGTNSSTDVVENIL 383
Cdd:NF040855 286 WEAVRRYVRKGNL-TPDMGGTATTKEVTRGII 316
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 55-386 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 587.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633   55 GGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIDPSTEGN-DDLDYAITSIKRNGVALKGNIETKSQSLTEVS 133
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKtEIPDEAVESIKRNKVALKGPLETPIGKGGHRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  134 RNVAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQ 213
Cdd:TIGR00175  81 LNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  214 NNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGG 293
Cdd:TIGR00175 161 NGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  294 AGLISGRNYGDHYAIFEPGTRNTGTAIAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVNDAIRTPDIGGTN 373
Cdd:TIGR00175 241 PGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGTA 320

                         330
                  ....*....|...
gi 161078633  374 SSTDVVENILKIL 386
Cdd:TIGR00175 321 TTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 33-386 4.71e-118

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 347.62  E-value: 4.71e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  33 VAHTKSALQKKVTGTDIPSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIdpSTEGNDDLDYAITSIK 112
Cdd:PLN00123   6 LSNALGSKAQRRSVTYMPRPGDGAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEV--HGDMKKVPEEVLESIR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 113 RNGVALKGNIETKSQSLTEvSRNVAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESM 192
Cdd:PLN00123  84 RNKVCLKGGLATPVGGGVS-SLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 193 KVVTVENAERVARYAFEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDV 272
Cdd:PLN00123 163 KVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDV 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 273 MNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHYAIFEPGTR--NTGT-AIAGKNIANPVAMISASIDMLNHLGHKEHAN 349
Cdd:PLN00123 243 MVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASagNVGNeKLVEQKKANPVALLLSSAMMLRHLQFPSFAD 322

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 161078633 350 VIQEAVYQTIVNDAIRTPDIGGTNSSTDVVENILKIL 386
Cdd:PLN00123 323 RLETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANL 359
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 57-386 1.62e-103

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 310.02  E-value: 1.62e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  57 RHAVTMLPGGGIGPELMGYVREIF----RYCGAPIDFEVIDI---------DPSTEgnDDLDyaitSIKRNGVALKGNIE 123
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLeaaaERFGLDFEFEEADIggaaydktgTPLPD--ETLE----ALRKADAILLGAVG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 124 TKS--QSLTEVSRNVAIRNELDLYVNVVHCKSYPGIPARHH-----DIDVVLIRQNTDGEYAMLEHESVPG----IVESM 192
Cdd:COG0473   75 GPKwdDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLKpeiveGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 193 KVVTVENAERVARYAFEFARQNnRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDV 272
Cdd:COG0473  155 RVYTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 273 MNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHY-AIFEPGtrnTGTA--IAGKNIANPVAMISASIDMLNHLGHKEHAN 349
Cdd:COG0473  234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPV---HGSApdIAGKGIANPIATILSAAMMLRHLGEEEAAD 310

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 161078633 350 VIQEAVYQTIvNDAIRTPDIGGTNSSTDVVENILKIL 386
Cdd:COG0473  311 AIEAAVEKVL-AEGVRTPDLGGKAGTSEMGDAIIAAL 346
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 61-382 1.40e-98

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 298.33  E-value: 1.40e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  61 TMLPGGGIGPELMGYVREIFRYCGAPIDFEV----IDIDPSTEGNDDLDyAITSIKRNGVALKGNIET---KSQSltevS 133
Cdd:PLN00118  45 TLFPGDGIGPEIAESVKQVFTAAGVPIEWEEhyvgTTVDPRTGSFLTWE-SLESVRRNKVGLKGPMATpigKGHR----S 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 134 RNVAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQ 213
Cdd:PLN00118 120 LNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKT 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 214 NNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGG 293
Cdd:PLN00118 200 HGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGG 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 294 AGLISGRNYGDHYAIFEPGTRNTGTAIAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVNDAIRTPDIGGTN 373
Cdd:PLN00118 280 LGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGSS 359


                 ....*....
gi 161078633 374 SSTDVVENI 382
Cdd:PLN00118 360 TTTDFTKAI 368
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
60-369 2.14e-98

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 301.42  E-value: 2.14e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  60 VTMLPGGGIGPELMGYVREIFRYCGAPIDFEVID-------------IDPSTegnddldyaITSIKRNGVALKGNIETkS 126
Cdd:PRK09222   7 ITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEigekvykkgwtsgISPSA---------WESIRRTKVLLKAPITT-P 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 127 QSLTEVSRNVAIRNELDLYVNVVHCKSY-PGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVAR 205
Cdd:PRK09222  77 QGGGYKSLNVTLRKTLGLYANVRPCVSYhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKIIR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 206 YAFEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSN 285
Cdd:PRK09222 157 YAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSD 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 286 VLCGLMGGAGLISGRNYGDHYAIFEPgtrNTGTA--IAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIvNDA 363
Cdd:PRK09222 237 IAAEISGSVGLAGSANIGEEYAMFEA---VHGSApdIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTL-EDG 312


                 ....*.
gi 161078633 364 IRTPDI 369
Cdd:PRK09222 313 IHTADI 318
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 60-386 3.22e-97

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 293.55  E-value: 3.22e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  60 VTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDID-PSTEGNDDL--DYAITSIKRNGVALKGNIETK-SQSLTEVsrN 135
Cdd:PRK08997   5 ITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGlTALEKHGELlpQRTLDLIEKNKIALKGPLTTPvGEGFTSI--N 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 136 VAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHE-SVPG-IVESMKVVTVENAERVARYAFEFARQ 213
Cdd:PRK08997  83 VTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTvSEDGeTAEATSIITRKGAERIVRFAYELARK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 214 NNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGG 293
Cdd:PRK08997 163 EGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVGG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 294 AGLISGRNYGDHYAIFEpGTRNTGTAIAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVNDAIRTPDIGGTN 373
Cdd:PRK08997 243 LGMAPGANIGRDAAIFE-AVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLGGTH 321

                        330
                 ....*....|...
gi 161078633 374 SSTDVVENILKIL 386
Cdd:PRK08997 322 GTTDFTQAVIDRL 334
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 58-386 7.01e-81

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 251.59  E-value: 7.01e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  58 HAVTMLPGGGIGPELMGYVREIFRYCGapIDFEVIDIDPSTEgnddldyaitSIKRNGVAL-KGNIETKSQS-------L 129
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEATG--LPFEFVYAEAGDE----------VFEKTGKALpEETIEAAKEAdavlfgaA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 130 TEVSRNVAI--RNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYA 207
Cdd:PRK14025  70 GETAADVIVklRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFA 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 208 FEFAR----QNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIV 283
Cdd:PRK14025 150 FEMAKrrkkMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDIL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 284 SNVLCGLMGGAGLISGRNYGDHYAIFEPgTRNTGTAIAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVNdA 363
Cdd:PRK14025 230 SDGAAGLVGGLGLAPSANIGDKYGLFEP-VHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLAL-G 307

                        330       340
                 ....*....|....*....|...
gi 161078633 364 IRTPDIGGTNSSTDVVENILKIL 386
Cdd:PRK14025 308 LTTPDLGGNLSTMEMAEEVAKRV 330
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
60-382 1.73e-78

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 246.05  E-value: 1.73e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633   60 VTMLPGGGIGPELMGYVREIFRYC----GAPIDFEVIDIDPST--EGNDDL-DYAITSIKRNGVALKGNIETKSQSLTEV 132
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAAlekaPLEFEFEERDVGGAAidETGEPLpDETLEACKKADAVLLGAVGGPKWDPAGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  133 -SRN--VAIRNELDLYVNVVHCKSYPGI----PARHH--DIDVVLIRQNTDGEYAMLEHESVPGIVE---SMKVVTVENA 200
Cdd:pfam00180  82 rPENglLALRKELGLFANLRPAKVFPPLgdasPLKNEveGVDIVIVRELTGGIYFGIEKGIKGSGNEvavDTKLYSRDEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  201 ERVARYAFEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYG 280
Cdd:pfam00180 162 ERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  281 TIVSNVLCGLMGGAGLISGRNYGDH-YAIFEPgTRNTGTAIAGKNIANPVAMISASIDMLNH-LGHKEHANVIQEAVYQT 358
Cdd:pfam00180 242 DILSDEASMLTGSLGLLPSASLGANgFGIFEP-VHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320

                         330       340
                  ....*....|....*....|....*..
gi 161078633  359 IvNDAIRTPDIGGTN---SSTDVVENI 382
Cdd:pfam00180 321 L-ESGIRTGDLAGSAtyvSTSEFGEAV 346
ICDH_alpha TIGR02924
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ...
 60-369 7.04e-76

isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]


Pssm-ID: 274353 [Multi-domain]  Cd Length: 473  Bit Score: 243.13  E-value: 7.04e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633   60 VTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIDPSTEgNDDLDYAIT-----SIKRNGVALKGNIETkSQSLTEVSR 134
Cdd:TIGR02924   3 ITVAYGDGIGPEIMEAVLLILKEAEAPIDIETIEIGEKVY-KKGWPSGISpssweSIRRTKVLLKAPITT-PQGGGHKSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  135 NVAIRNELDLYVNVVHCKSY-PGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQ 213
Cdd:TIGR02924  81 NVTLRKTLGLYANIRPCVSYhPFIETKSPNLNIVIVRENEEDLYTGIEYRQTPDTYECTKLITRSGSEKICRYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  214 NNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGG 293
Cdd:TIGR02924 161 HNRKKVTCLTKDNIMKMTDGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYGDILSDVAAEISGS 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161078633  294 AGLISGRNYGDHYAIFEpGTRNTGTAIAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIvNDAIRTPDI 369
Cdd:TIGR02924 241 VGLAGSANIGEEYAMFE-AVHGSAPDIAGQNIANPSGLLNAAIQMLVHIGQSDIAQLIYNAWLKTL-EDGVHTADI 314
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 60-389 2.20e-50

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 173.36  E-value: 2.20e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  60 VTMLPGGGIGPELMGYVREIFRYCGAPIDFEVididpstegndDLDYAIT---SIKRNGVAL-KGNIETKSQS------- 128
Cdd:PRK00772   5 IAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDF-----------EFEEALVggaAIDAHGVPLpEETLEACRAAdavllga 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 129 -----LTEVSRNV-------AIRNELDLYVNVVHCKSYPGI-------PARHHDIDVVLIRQNTDGEY--------AMLE 181
Cdd:PRK00772  74 vggpkWDNLPPDVrpergllALRKELGLFANLRPAKLYPGLadasplkPEIVAGLDILIVRELTGGIYfgeprgreGLGG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 182 HESVpgiVESMkVVTVENAERVARYAFEFARQNnRKKVTTIHKANIMKlSDGLFLEVANRVHKDYPELEHNNMIIDNTCM 261
Cdd:PRK00772 154 EERA---FDTM-VYTREEIERIARVAFELARKR-RKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAM 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 262 QSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDH-YAIFEPGtrnTGTA--IAGKNIANPVAMI-SASId 337
Cdd:PRK00772 228 QLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPI---HGSApdIAGKGIANPIATIlSAAM- 303

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 161078633 338 MLNH-LGHKEHANVIQEAVYQTIvNDAIRTPDI---GGTNSSTDVVENILKILSAK 389
Cdd:PRK00772 304 MLRYsLGLEEAADAIEAAVEKVL-AQGYRTADIaegGGKVSTSEMGDAILAALAEG 358
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 136-386 2.77e-48

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 167.59  E-value: 2.77e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 136 VAIRNELDLYVNVVHCKSYPGI--PARH-HDIDVVLIRQNTDGEYAML-------EHEsvpgIVESMKVVTVENAERVAR 205
Cdd:PRK08194  93 IKIRREFEQVINIRPAKQLRGIksPLANpKDFDLLVVRENSEGEYSEVggrihrgEDE----IAIQNAVFTRKGTERAMR 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 206 YAFEFARqNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSN 285
Cdd:PRK08194 169 YAFELAA-KRRKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEFDVIVASNLFGDILTD 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 286 VLCGLMGGAGLISGRN---YGDHYAIFEPgTRNTGTAIAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTiVND 362
Cdd:PRK08194 248 IGAAIMGSIGIAPAANinvNGKYPSMFEP-VHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVIEDV-TED 325

                        250       260
                 ....*....|....*....|....
gi 161078633 363 AIRTPDIGGTNSSTDVVENILKIL 386
Cdd:PRK08194 326 GIKTPDIGGRATTDEVTDEIISRL 349
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 138-370 4.31e-41

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 148.15  E-value: 4.31e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 138 IRNELDLYVNVVHCKSYPGIP---ARHHDIDVVLIRQNTDGEYA--------MLEHEsvpgIVESMKVVTVENAERVARY 206
Cdd:PRK03437  93 LRFALDHYVNLRPSKLYPGVTsplAGPGDIDFVVVREGTEGPYTgnggalrvGTPHE----VATEVSVNTAFGVERVVRD 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 207 AFEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNV 286
Cdd:PRK03437 169 AFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTDNLFGDIITDL 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 287 LCGLMGGAGLISGRNY---GDHYAIFEPgtrNTGTA--IAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVN 361
Cdd:PRK03437 249 AAAVTGGIGLAASGNInptGTNPSMFEP---VHGSApdIAGQGIADPTAAILSVALLLDHLGEEDAAARIEAAVEADLAE 325

                        250
                 ....*....|..
gi 161078633 362 DA---IRTPDIG 370
Cdd:PRK03437 326 RGkmgRSTAEVG 337
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
65-387 1.55e-39

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 145.74  E-value: 1.55e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  65 GGGIGPELMGYVREIF-----RYCGAPIDF---EVIDIDPSTE--GNDDLDYAITSIKRNGVALKGNIETKSQSLTEvSR 134
Cdd:PRK06451  31 GDGIGPEITHAAMKVInkaveKAYGSDREIkwvEVLAGDKAEKltGNRFPKESEELIEKYRVLLKGPLETPIGKGWK-SI 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 135 NVAIRNELDLYVNVVHCKSYPGI--PARHHD-IDVVLIRQNTDGEYAMLEH----------------------ESVPGIv 189
Cdd:PRK06451 110 NVAIRLMLDLYANIRPVKYIPGIesPLKNPEkIDLIIFRENTDDLYRGIEYpydseeakkirdflrkelgvevEDDTGI- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 190 eSMKVVTVENAERVARYAFEFARQNNRKKVTTIHKANIMKLSDGLF----LEVANRVHKDYPELEH-------------- 251
Cdd:PRK06451 189 -GIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFrewaYEVALKEFRDYVVTEEevtknyngvppsgk 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 252 ---NNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHYAIFEpGTRNTGTAIAGKNIANP 328
Cdd:PRK06451 268 viiNDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE-AIHGTAPKYAGKNVANP 346

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161078633 329 VAMISASIDMLNHLGHKEHANVIQEAVYQTIvNDAIRTPDIG--------GTNSSTDVVENILKILS 387
Cdd:PRK06451 347 TGIIKGGELMLRFMGWDKAADLIDKAIMESI-KQKKVTQDLArfmgvralSTTEYTDELISIIDMLS 412
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 107-359 3.48e-39

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 144.87  E-value: 3.48e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 107 AITSIKRNGVALKGNIET------KSQsltevsrNVAIRNELDLYVNVVHCKSYPGIPA--RH-HDIDVVLIRQNTDGEY 177
Cdd:COG0538   78 TAEAIKEYGVGIKGPLTTpvgggwRSL-------NVTIRQILDLYVCRRPVRYFKGVPSpvKHpEKVDIVIFRENTEDIY 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 178 AMLE-------------------------HESVPGIVesMKVVTVENAERVARYAFEFARQNNRKKVTTIHKANIMKLSD 232
Cdd:COG0538  151 AGIEwkagspealkliffledemgvtvirFPEDSGIG--IKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTE 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 233 G----LFLEVANRVHKDY-----PELEHNN-----------MIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMG 292
Cdd:COG0538  229 GafkdWGYEVAEEEFGDKfitegPWEKYKGpkpagkivykdRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVG 308

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161078633 293 GAGLISGRNYGDHY-AIFEPgTRNTGTAIAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTI 359
Cdd:COG0538  309 GLGIAPGANIGDDGgAEFEA-THGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTI 375
iso_homocit_dh NF040855
isocitrate--homoisocitrate dehydrogenase;
60-383 7.21e-35

isocitrate--homoisocitrate dehydrogenase;


Pssm-ID: 468794  Cd Length: 345  Bit Score: 131.84  E-value: 7.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  60 VTMLPGGGIGPELM-----------GYVR--------EIFRYCGAPIDfevididpstegNDDLDyaitSIKRNGVALKG 120
Cdd:NF040855   4 VAVIKGDGIGPEVIdaairvvnavtDRIRfyefeggfEVFKRYGSPIR------------EEDLE----EIRKMDAVLFG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 121 NIETKSQSLTEVSRNVAIRNELDLYVNVVHcksypgIPARHHDIDVVLIRQNTDGEYAMLehesvpGIVESMKVV----- 195
Cdd:NF040855  68 ATTTPFDVPGYKSLIITLRKELDLYANLRI------IPDLWNGREIVIVRENSEGLYSGL------GAVFSDRAVdfrii 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 196 TVENAERVARYAFEFARQNNrKKVTTIHKANIMKlSDGLF----LEVANRvhkdyPELEHNNMIIDNTCMQSVSNPHQFD 271
Cdd:NF040855 136 TREGAERIARFAVNLAKERG-SFITFVHKANVLT-GDKFFrkivLEIAER-----EGVEVREAIVDSFTIKLVRNPWNHG 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 272 VMNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHYAIFEPgTRNTGTAIAGKNIANPVAMISASIDMLNHLGHkeHANVI 351
Cdd:NF040855 209 VILSENLFGDILSDLATIHAGSIGIVPSGNYGDDIALFEP-IHGSAPDIAGKGIANPIGAILSAAMMLDYLGL--DGSII 285

                        330       340       350
                 ....*....|....*....|....*....|..
gi 161078633 352 QEAVYQTIVNDAIrTPDIGGTNSSTDVVENIL 383
Cdd:NF040855 286 WEAVRRYVRKGNL-TPDMGGTATTKEVTRGII 316
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 133-361 4.35e-34

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 130.95  E-value: 4.35e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 133 SRNVAIRNELDLYVNVVHCKSYPGIPA---RHHDIDVVLIRQNTDGEYAMLEHESvpGIVESMKV--------------- 194
Cdd:PRK07006 106 SLNVALRQELDLYVCLRPVRYFKGVPSpvkRPEDTDMVIFRENSEDIYAGIEWKA--GSAEAKKVikflqeemgvkkirf 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 195 ----------VTVENAERVARYAFEFARQNNRKKVTTIHKANIMKLSDGLF----LEVANRVHKDYP------------- 247
Cdd:PRK07006 184 petsgigikpVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFkdwgYQLAEEEFGDELidggpwdkiknpe 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 248 ---ELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHYAIFEpGTRNTGTAIAGKN 324
Cdd:PRK07006 264 tgkEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFE-ATHGTAPKYAGLD 342

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 161078633 325 IANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVN 361
Cdd:PRK07006 343 KVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIAS 379
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 57-369 1.63e-24

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 104.00  E-value: 1.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633  57 RHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEvIDIDPSTEGNDDLDY--------AITSIKRNGVALKGNI-----E 123
Cdd:PLN02329  46 RYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLE-FDFQEMPVGGAALDLvgvplpeeTFTAAKQSDAILLGAIggykwD 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 124 TKSQSLTEVSRNVAIRNELDLYVNVVHCKSYPGI-------PARHHDIDVVLIRQNTDGEY-----AMLEHESVPGIVES 191
Cdd:PLN02329 125 KNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYfgeprGITINENGEEVGVS 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 192 MKVVTVENAERVARYAFEFARQNnRKKVTTIHKANIMKLSDgLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFD 271
Cdd:PLN02329 205 TEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 272 VMNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDH-YAIFEPgTRNTGTAIAGKNIANPVAMISASIDMLNH-LGHKEHAN 349
Cdd:PLN02329 283 TIVTNNIFGDILSDEASMITGSIGMLPSASLGESgPGLFEP-IHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAK 361

                        330       340
                 ....*....|....*....|
gi 161078633 350 VIQEAVYQTIvNDAIRTPDI 369
Cdd:PLN02329 362 RIEDAVVDAL-NKGFRTGDI 380
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
108-361 6.88e-21

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 94.01  E-value: 6.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 108 ITSIKRNGVALKGNIETKS----QSLtevsrNVAIRNELDLYVNVVHCKSYPGIPARH---HDIDVVLIRQNTDGEYAML 180
Cdd:PRK07362  91 LEAIREYGVAIKGPLTTPIgggiRSL-----NVALRQIFDLYSCVRPCRYYAGTPSPHknpEKLDVIVYRENTEDIYMGI 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 181 EHES----------------VP--------------GIveSMKVVTVENAERVARYAFEFARQ--NNRKKVTTIHKANIM 228
Cdd:PRK07362 166 EWEAgdeigdklikhlneevIPaspelgkrqiplgsGI--GIKPVSKTGSQRHIRRAIEHALRlpGDKRHVTLVHKGNIM 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 229 KLSDGLF---------------------------------LEVANRVHKDYP---------------ELE---------H 251
Cdd:PRK07362 244 KYTEGAFrdwgyelattefrdecvtereswilsnkeknpnISIEDNARMIEPgydsltpekkaaicaEVKevldsiwssH 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078633 252 -----------NNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHYAIFEpGTRNTGTAI 320
Cdd:PRK07362 324 gngkwkekvlvDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFE-ATHGTAPKH 402

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 161078633 321 AGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVN 361
Cdd:PRK07362 403 AGLDRINPGSVILSGVMMLEYLGWQEAADLITKGLSAAIAN 443
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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