NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|157823966|ref|NP_001101362|]
View 

low-density lipoprotein receptor-related protein 6 isoform 1 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 441-476 2.97e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.87  E-value: 2.97e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157823966   441 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 476
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1137-1171 8.58e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 8.58e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157823966 1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1171
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 246-286 9.78e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 9.78e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157823966    246 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 286
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 332-373 1.35e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.31  E-value: 1.35e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157823966    332 VLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGR 373
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 307-348 1.44e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.25  E-value: 1.44e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   307 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 348
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1175-1209 2.28e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 2.28e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157823966 1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDC 1209
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 742-778 5.20e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.41  E-value: 5.20e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157823966   742 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 778
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 546-588 5.30e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 5.30e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157823966    546 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 588
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
503-662 5.83e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 5.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  503 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 582
Cdd:COG3391    60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  583 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 655
Cdd:COG3391   137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                  ....*..
gi 157823966  656 WTDLDTN 662
Cdd:COG3391   214 VANRGSN 220
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1-40 9.89e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.94  E-value: 9.89e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157823966     1 MYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDY 40
Cdd:pfam00058    3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 135-172 2.17e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.48  E-value: 2.17e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157823966   135 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLESGKTC 172
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 24-65 5.99e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 5.99e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157823966     24 VIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNR 65
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1098-1134 1.52e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.52e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 157823966 1098 CSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDELNC 1134
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1056-1092 1.91e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 1.91e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157823966  1056 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1092
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 202-242 5.86e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 5.86e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157823966    202 VLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSG 242
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 943-985 1.39e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 1.39e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157823966    943 EVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANR 985
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 676-715 1.00e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.00e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157823966    676 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 715
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 374-407 3.37e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 3.37e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 157823966    374 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 407
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
817-924 4.60e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 4.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  817 RAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQgftvVVSSVPnqnLEIQPYDLSIDIYSRYIYWTCEATN-------VIDV 889
Cdd:COG3391   113 RGLAVDPDGGRLYVADSGNGRVSVIDTATGK----VVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsvivsVIDT 185

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 157823966  890 TrlDGRSVGVVLKGEQdrPRAIVVNPEKGYMYFTN 924
Cdd:COG3391   186 A--TGKVVATIPVGGG--PVGVAVSPDGRRLYVAN 216
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 66-100 1.66e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 1.66e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 157823966     66 QAVVKGSLPHP--FALTLFEDTLYWTDWNTHSILACN 100
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
 
Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 441-476 2.97e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.87  E-value: 2.97e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157823966   441 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 476
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1137-1171 8.58e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 8.58e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157823966 1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1171
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 246-286 9.78e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 9.78e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157823966    246 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 286
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 332-373 1.35e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.31  E-value: 1.35e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157823966    332 VLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGR 373
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 307-348 1.44e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.25  E-value: 1.44e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   307 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 348
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1175-1209 2.28e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 2.28e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157823966 1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDC 1209
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 742-778 5.20e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.41  E-value: 5.20e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157823966   742 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 778
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 546-588 5.30e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 5.30e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157823966    546 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 588
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 287-330 5.41e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 5.41e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157823966    287 KILISEDLEEPRAIVLDPMAGYMYWTDWGEiPKIERAALDGSDR 330
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
503-662 5.83e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 5.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  503 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 582
Cdd:COG3391    60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  583 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 655
Cdd:COG3391   137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                  ....*..
gi 157823966  656 WTDLDTN 662
Cdd:COG3391   214 VANRGSN 220
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1-40 9.89e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.94  E-value: 9.89e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157823966     1 MYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDY 40
Cdd:pfam00058    3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1137-1171 1.55e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 1.55e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 157823966  1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1171
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 135-172 2.17e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.48  E-value: 2.17e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157823966   135 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLESGKTC 172
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 24-65 5.99e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 5.99e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157823966     24 VIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNR 65
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1137-1168 8.85e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 8.85e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 157823966   1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDE 1168
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1098-1134 1.52e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.52e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 157823966 1098 CSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDELNC 1134
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 210-372 3.48e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 59.25  E-value: 3.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  210 HAIAIDYDpveGYVYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 284
Cdd:cd05819    58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  285 MRKIL-----ISEDLEEPRAIVLDPmAGYMYWTDWgeipkieraaldGSDRVVLVNT----------------SLGWPNG 343
Cdd:cd05819   134 FLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADT------------GNHRIQVFDPdgnflttfgstgtgpgQFNYPTG 200

                         170       180
                  ....*....|....*....|....*....
gi 157823966  344 LALDyDEGTIYWGDAKTDKIEVMNTDGTG 372
Cdd:cd05819   201 IAVD-SDGNIYVADSGNNRVQVFDPDGAG 228
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
210-377 6.25e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 58.17  E-value: 6.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  210 HAIAIDYDPVEGYVYWTDDEVRAIrrSFIDGSGSQFVVT-AQIAHPDGIAVDWVARNLYWTDTGTDRieVTRLNGTMRKI 288
Cdd:COG3391    69 DADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATiPVGGGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  289 LISEDL-EEPRAIVLDPMAGYMYWTDWG--EIPKIErAALDGSDRVVLVNTSLG-WPNGLALDYDEGTIYWGDAKTDKie 364
Cdd:COG3391   145 VATIPVgAGPHGIAVDPDGKRLYVANSGsnTVSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT-- 221

                         170
                  ....*....|...
gi 157823966  365 vmnTDGTGRRVLV 377
Cdd:COG3391   222 ---SNGGSNTVSV 231
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1175-1206 7.61e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 7.61e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 157823966   1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDE 1206
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1097-1131 1.06e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 1.06e-08
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 157823966   1097 TCSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDE 1131
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1056-1092 1.91e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 1.91e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157823966  1056 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1092
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 589-632 3.19e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 3.19e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157823966    589 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 632
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1175-1209 6.23e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 6.23e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 157823966  1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDC 1209
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1097-1134 6.35e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 6.35e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157823966  1097 TCSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDELNC 1134
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 264-304 1.09e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 1.09e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   264 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 304
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 202-242 5.86e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 5.86e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157823966    202 VLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSG 242
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 943-985 1.39e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 1.39e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157823966    943 EVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANR 985
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 609-649 1.72e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 1.72e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   609 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 649
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 548-662 1.01e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  548 VVEF-GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDR 624
Cdd:cd14952     3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 157823966  625 AAmdGSERTTLVP--NVGRANGLTIDyAKRRLYWTDLDTN 662
Cdd:cd14952    79 AA--GSTTQTVLPftGLNDPTGVAVD-AAGNVYVADTGNN 115
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 567-606 4.83e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 4.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 157823966   567 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 606
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 676-715 1.00e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.00e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157823966    676 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 715
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 374-407 3.37e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 3.37e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 157823966    374 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 407
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
817-924 4.60e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 4.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  817 RAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQgftvVVSSVPnqnLEIQPYDLSIDIYSRYIYWTCEATN-------VIDV 889
Cdd:COG3391   113 RGLAVDPDGGRLYVADSGNGRVSVIDTATGK----VVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsvivsVIDT 185

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 157823966  890 TrlDGRSVGVVLKGEQdrPRAIVVNPEKGYMYFTN 924
Cdd:COG3391   186 A--TGKVVATIPVGGG--PVGVAVSPDGRRLYVAN 216
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 807-847 5.29e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 5.29e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157823966    807 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQ 847
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 221-261 6.94e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 6.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   221 GYVYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 261
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 43-83 1.09e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 1.09e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966    43 RKLYWADAKLNF-IHKSNLDGTNRQAVVKGSLPHPFALTLFE 83
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 66-100 1.66e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 1.66e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 157823966     66 QAVVKGSLPHP--FALTLFEDTLYWTDWNTHSILACN 100
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 964-1003 3.60e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.37  E-value: 3.60e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 157823966   964 RLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 1003
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 553-619 3.92e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.76  E-value: 3.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157823966  553 LDYPEGMAVDWLGkNLYWADTGTNRIevSKLDGQHRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGK 619
Cdd:cd05819    54 FNEPAGVAVDSDG-NLYVADTGNHRI--QKFDPDGNFLASFggsgdgdGEFNGPRGIAVDSS-GNIYVADTGNH 123
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1-22 6.15e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 6.15e-03
                            10        20
                    ....*....|....*....|..
gi 157823966      1 MYWTDWGEvPKIERAGMDGSSR 22
Cdd:smart00135   23 LYWTDWGL-DVIEVANLDGTNR 43
 
Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 441-476 2.97e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.87  E-value: 2.97e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157823966   441 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 476
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1137-1171 8.58e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 8.58e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157823966 1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1171
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 246-286 9.78e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 9.78e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157823966    246 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 286
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 332-373 1.35e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.31  E-value: 1.35e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157823966    332 VLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGR 373
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 307-348 1.44e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.25  E-value: 1.44e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   307 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 348
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1175-1209 2.28e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 2.28e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157823966 1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDC 1209
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 742-778 5.20e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.41  E-value: 5.20e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157823966   742 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 778
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 546-588 5.30e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 5.30e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157823966    546 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 588
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 287-330 5.41e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 5.41e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157823966    287 KILISEDLEEPRAIVLDPMAGYMYWTDWGEiPKIERAALDGSDR 330
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
503-662 5.83e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 5.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  503 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 582
Cdd:COG3391    60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  583 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 655
Cdd:COG3391   137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                  ....*..
gi 157823966  656 WTDLDTN 662
Cdd:COG3391   214 VANRGSN 220
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1-40 9.89e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.94  E-value: 9.89e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157823966     1 MYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDY 40
Cdd:pfam00058    3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1137-1171 1.55e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 1.55e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 157823966  1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1171
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 135-172 2.17e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.48  E-value: 2.17e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157823966   135 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLESGKTC 172
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 24-65 5.99e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 5.99e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157823966     24 VIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNR 65
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1137-1168 8.85e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 8.85e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 157823966   1137 CSESQFQCASGQCIDGALRCNGDANCQDKSDE 1168
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1098-1134 1.52e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.52e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 157823966 1098 CSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDELNC 1134
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 210-372 3.48e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 59.25  E-value: 3.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  210 HAIAIDYDpveGYVYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 284
Cdd:cd05819    58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  285 MRKIL-----ISEDLEEPRAIVLDPmAGYMYWTDWgeipkieraaldGSDRVVLVNT----------------SLGWPNG 343
Cdd:cd05819   134 FLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADT------------GNHRIQVFDPdgnflttfgstgtgpgQFNYPTG 200

                         170       180
                  ....*....|....*....|....*....
gi 157823966  344 LALDyDEGTIYWGDAKTDKIEVMNTDGTG 372
Cdd:cd05819   201 IAVD-SDGNIYVADSGNNRVQVFDPDGAG 228
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
210-377 6.25e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 58.17  E-value: 6.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  210 HAIAIDYDPVEGYVYWTDDEVRAIrrSFIDGSGSQFVVT-AQIAHPDGIAVDWVARNLYWTDTGTDRieVTRLNGTMRKI 288
Cdd:COG3391    69 DADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATiPVGGGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  289 LISEDL-EEPRAIVLDPMAGYMYWTDWG--EIPKIErAALDGSDRVVLVNTSLG-WPNGLALDYDEGTIYWGDAKTDKie 364
Cdd:COG3391   145 VATIPVgAGPHGIAVDPDGKRLYVANSGsnTVSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT-- 221

                         170
                  ....*....|...
gi 157823966  365 vmnTDGTGRRVLV 377
Cdd:COG3391   222 ---SNGGSNTVSV 231
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1175-1206 7.61e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 7.61e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 157823966   1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDE 1206
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1097-1131 1.06e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 1.06e-08
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 157823966   1097 TCSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDE 1131
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1056-1092 1.91e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 1.91e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157823966  1056 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1092
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 589-632 3.19e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 3.19e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157823966    589 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 632
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1175-1209 6.23e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 6.23e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 157823966  1175 CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDC 1209
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1097-1134 6.35e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 6.35e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157823966  1097 TCSPQQFTCFTGDidCIPVAWRCDGFTECEDHSDELNC 1134
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 264-304 1.09e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 1.09e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   264 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 304
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 632-674 1.15e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 1.15e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157823966    632 RTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNR 674
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
210-398 2.37e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 53.16  E-value: 2.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  210 HAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRK 287
Cdd:COG3391    26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVidLATGKVVAT 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  288 ILISEDleePRAIVLDPMAGYMYWTDWGEiPKIerAALDGSDRVVLVNTSLG-WPNGLALDYDEGTIYWGDAKTDKI--- 363
Cdd:COG3391   106 IPVGGG---PRGLAVDPDGGRLYVADSGN-GRV--SVIDTATGKVVATIPVGaGPHGIAVDPDGKRLYVANSGSNTVsvi 179

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 157823966  364 -EVMNT-DGTGRRVLVEDKIPHIFGFTLLGDYVYWTD 398
Cdd:COG3391   180 vSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 216-407 4.26e-07

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 52.97  E-value: 4.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  216 YDPvEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQiAHPDGIAVD-----WVARN---LYWTDTGTDRIEVtrlngtmrk 287
Cdd:COG3386    15 WDP-DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADHgrgLVRFDPADGEVTV--------- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  288 ilISEDLEEPRA----IVLDPmAGYMYWTDwgeiPKIERAA-----LDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDA 358
Cdd:COG3386    84 --LADEYGKPLNrpndGVVDP-DGRLYFTD----MGEYLPTgalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 157823966  359 KTDKIEVMNTDGTG----RRVLVEDKIPHIF--GFTLLGD-YVYWTDWQRRSIERV 407
Cdd:COG3386   157 GAGRIYRFDLDADGtlgnRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVVRF 212
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 202-242 5.86e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 5.86e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157823966    202 VLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSG 242
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 210-371 1.13e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 51.51  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  210 HAIAIDYDpveGYVYWTDD----------EVRAIRRSFIDGSGSQfvvtaQIAHPDGIAVDwVARNLYWTDTGTDRIEVT 279
Cdd:cd14956    16 RGIAVDAD---DNVYVADArngriqvfdkDGTFLRRFGTTGDGPG-----QFGRPRGLAVD-KDGWLYVADYWGDRIQVF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  280 RLNGTMRKILISE-----DLEEPRAIVLDPmAGYMYWTDWGEiPKIERAALDGSdrvvLVNT---------SLGWPNGLA 345
Cdd:cd14956    87 TLTGELQTIGGSSgsgpgQFNAPRGVAVDA-DGNLYVADFGN-QRIQKFDPDGS----FLRQwggtgiepgSFNYPRGVA 160

                         170       180
                  ....*....|....*....|....*.
gi 157823966  346 LDyDEGTIYWGDAKTDKIEVMNTDGT 371
Cdd:cd14956   161 VD-PDGTLYVADTYNDRIQVFDNDGA 185
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 943-985 1.39e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 1.39e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157823966    943 EVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANR 985
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 609-649 1.72e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 1.72e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   609 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 649
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-543 3.63e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.90  E-value: 3.63e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 157823966    505 IPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGS 543
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 211-315 8.80e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.85  E-value: 8.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  211 AIAIDYDpveGYVYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEV-----TR 280
Cdd:cd05819   153 GVAVDSD---GNIYVADTGNHRIQVfdpdgNFLTTFGSTGTGPGQFNYPTGIAVD-SDGNIYVADSGNNRVQVfdpdgAG 228

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 157823966  281 LNGTMRKILISEDLEEPRAIVLDPmAGYMYWTDWG 315
Cdd:cd05819   229 FGGNGNFLGSDGQFNRPSGLAVDS-DGNLYVADTG 262
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 251-376 9.46e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 9.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  251 IAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmAGYMYWTDWGEIPKIERAAlDGSDR 330
Cdd:cd14952     9 LDGPGGVAVD-AAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDA-AGTVYVTDFGNNRVLKLAA-GSTTQ 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 157823966  331 VVLVNTSLGWPNGLALDyDEGTIYwgdaktdkieVmnTDGTGRRVL 376
Cdd:cd14952    86 TVLPFTGLNDPTGVAVD-AAGNVY----------V--ADTGNNRVL 118
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 548-662 1.01e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  548 VVEF-GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDR 624
Cdd:cd14952     3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 157823966  625 AAmdGSERTTLVP--NVGRANGLTIDyAKRRLYWTDLDTN 662
Cdd:cd14952    79 AA--GSTTQTVLPftGLNDPTGVAVD-AAGNVYVADTGNN 115
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 552-662 1.44e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.97  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  552 GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLDGQH--RQVLVWKDLDSPRALALDPAeGFMYWTEWGGKpKIDRAAMDG 629
Cdd:cd14952    92 GLNDPTGVAVDAAG-NVYVADTGNNR--VLKLAAGSntQTVLPFTGLSNPDGVAVDGA-GNVYVTDTGNN-RVLKLAAGS 166

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 157823966  630 SERTTLvPNVGRA--NGLTIDyAKRRLYWTDLDTN 662
Cdd:cd14952   167 TTQTVL-PFTGLNspSGVAVD-TAGNVYVTDHGNN 199
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 212-370 2.95e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 47.20  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  212 IAIDYDPvEGYVYWTDDEVRAIrrsFIDGSGSQFV----VTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRK 287
Cdd:cd14962    60 IGVAIDA-NGNLYVSDAELGKV---FVFDRDGKFLraigAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLF 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  288 IL-----ISEDLEEPRAIVLDPmAGYMYWTDWGEIpKIERAALDGS-----DRVVLVNTSLGWPNGLALDyDEGTIYWGD 357
Cdd:cd14962   136 DIgkrgsGPGEFNLPTDLAVDR-DGNLYVTDTMNF-RVQIFDADGKflrsfGERGDGPGSFARPKGIAVD-SEGNIYVVD 212

                         170
                  ....*....|...
gi 157823966  358 AKTDKIEVMNTDG 370
Cdd:cd14962   213 AAFDNVQIFNPEG 225
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 567-606 4.83e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 4.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 157823966   567 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 606
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 254-376 9.40e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 45.28  E-value: 9.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  254 PDGIAVDwVARNLYWTDTGTDRieVTRLNG--TMRKILISEDLEEPRAIVLDPmAGYMYWTDWGEiPKIERAALDGSDRV 331
Cdd:cd14952    96 PTGVAVD-AAGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPDGVAVDG-AGNVYVTDTGN-NRVLKLAAGSTTQT 170

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 157823966  332 VLVNTSLGWPNGLALDyDEGTIYwgdaktdkieVmnTDGTGRRVL 376
Cdd:cd14952   171 VLPFTGLNSPSGVAVD-TAGNVY----------V--TDHGNNRVL 202
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 676-715 1.00e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.00e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157823966    676 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 715
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
DUF5050 pfam16472
Domain of unknown function (DUF5050);
222-398 1.12e-04

Domain of unknown function (DUF5050);


Pssm-ID: 465128 [Multi-domain]  Cd Length: 282  Bit Score: 45.70  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966   222 YVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDgIAVDWVarnlYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPraI 300
Cdd:pfam16472  111 YQHYDNSDGGTLYKIKIDGKEKTKLSDEPISPAS-VSDGWI----YYSGTSDDhYIYKLNTDGDSISKLYDGNSYMP--N 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966   301 VLDpmaGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNglaldYDEGTIYWGDAKTD-KIEVMNTDGTGRRVLVED 379
Cdd:pfam16472  184 VNG---DYIYYIDLSNNYALYRMNLSGGEKEVLTDDRVDNYN-----VYGNWIYYQNNGDDnKLYRINTDGSNKEKLAEG 255

                          170
                   ....*....|....*....
gi 157823966   380 KIPHIfgfTLLGDYVYWTD 398
Cdd:pfam16472  256 NYTNI---NITSDYIYFTD 271
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 250-376 1.18e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.39  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  250 QIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTmRKILISED------LEEPRAIVLDPmAGYMYWTDWG--EIPKIe 321
Cdd:cd05819     6 ELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGN-FITSFGSFgsgdgqFNEPAGVAVDS-DGNLYVADTGnhRIQKF- 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157823966  322 raalDGSDRVVLVNTSLGW-------PNGLALDyDEGTIYWGDAKTDKIEVMNTDGTGRRVL 376
Cdd:cd05819    82 ----DPDGNFLASFGGSGDgdgefngPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTF 138
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 216-378 1.66e-04

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 44.56  E-value: 1.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966   216 YDPVEGYVYWTDDEVRAIRR-SFIDGSGSQFVVTAQIA----HPDGIAVDWVARNLYWTDTGTdrievtrlnGTMRKILI 290
Cdd:pfam08450    7 WDEEEGALYWVDILGGRIHRlDPATGKETVWDTPGPVGaiapRDDGGLIVALKDGVALLDLAT---------GELTPLAD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966   291 SEDLEEPRAI----VLDPmAGYMYWTDWG--EIPKIERAAL---DGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTD 361
Cdd:pfam08450   78 PEDDDWPLNRfndgKVDP-DGRFWFGTMGddEAPGGDPGALyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPAR 156

                          170       180
                   ....*....|....*....|..
gi 157823966   362 KIEVMNTDGTG-----RRVLVE 378
Cdd:pfam08450  157 KIWAYDYDLDGglisnRRVFAD 178
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 522-706 1.72e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.88  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  522 DNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGkNLYWADTGtNRIEVSKLDGQHRQVLV---WKDLDS 598
Cdd:COG3386    18 DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDPDG-RLLVADHG-RGLVRFDPADGEVTVLAdeyGKPLNR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  599 PRALALDPAeGFMYWT---EWGGKPKIDRAAMDGsERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLI-----ESSNML 670
Cdd:COG3386    95 PNDGVVDPD-GRLYFTdmgEYLPTGALYRVDPDG-SLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIyrfdlDADGTL 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 157823966  671 GlNREVIADDLPHPF---GLTQYQD-YIYWTDWSRRSIER 706
Cdd:COG3386   173 G-NRRVFADLPDGPGgpdGLAVDADgNLWVALWGGGGVVR 211
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 523-563 2.52e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 2.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   523 NRIYWTDISLK-TISRAFMNGSALEHVVEFGLDYPEGMAVDW 563
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 210-363 3.21e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.74  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  210 HAIAIDYDpveGYVYWTD-DEVRAIRRSfiDGSGSQFVVT-AQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRK 287
Cdd:cd14952    97 TGVAVDAA---GNVYVADtGNNRVLKLA--AGSNTQTVLPfTGLSNPDGVAVD-GAGNVYVTDTGNNRVLKLAAGSTTQT 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157823966  288 ILISEDLEEPRAIVLDPmAGYMYWTDWGEiPKIERAALDGSDRVVLVNTSLGWPNGLALDyDEGTIYWGDAKTDKI 363
Cdd:cd14952   171 VLPFTGLNSPSGVAVDT-AGNVYVTDHGN-NRVLKLAAGSTTPTVLPFTGLNGPLGVAVD-AAGNVYVADRGNDRV 243
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 374-407 3.37e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 3.37e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 157823966    374 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 407
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 554-634 3.98e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.81  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  554 DYPEGMAVDwLGKNLYWADTGTNRIEVSKLDGQH-RQvlVWK------DLDSPRALALDPAEGFMYWTEWGGkpKIDRAA 626
Cdd:cd14956    13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgdgpgQFGRPRGLAVDKDGWLYVADYWGD--RIQVFT 87


                  ....*...
gi 157823966  627 MDGSERTT 634
Cdd:cd14956    88 LTGELQTI 95
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
817-924 4.60e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 4.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  817 RAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQgftvVVSSVPnqnLEIQPYDLSIDIYSRYIYWTCEATN-------VIDV 889
Cdd:COG3391   113 RGLAVDPDGGRLYVADSGNGRVSVIDTATGK----VVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsvivsVIDT 185

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 157823966  890 TrlDGRSVGVVLKGEQdrPRAIVVNPEKGYMYFTN 924
Cdd:COG3391   186 A--TGKVVATIPVGGG--PVGVAVSPDGRRLYVAN 216
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 807-847 5.29e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 5.29e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157823966    807 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQ 847
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 211-363 6.75e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 43.29  E-value: 6.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  211 AIAIDydpVEGYVYWTDDEVRAIRR-------SFIDGSGSQF------VVTAQIAHPDGIAVDwVARNLYWTDTGTDRIE 277
Cdd:cd14953   136 GVAVD---AAGNLYVADTGNHRIRKitpdgvvTTVAGTGGAGyagdgpATAAQFNNPTGVAVD-AAGNLYVADRGNHRIR 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  278 VTRLNGTMRKIL------ISED-------LEEPRAIVLDPmAGYMYWTDWG--EIPKIERA------ALDGS----DRVV 332
Cdd:cd14953   212 KITPDGVVTTVAgtgtagFSGDggataaqLNNPTGVAVDA-AGNLYVADSGnhRIRKITPAgvvttvAGGGAgfsgDGGP 290

                         170       180       190
                  ....*....|....*....|....*....|.
gi 157823966  333 LVNTSLGWPNGLALDyDEGTIYWGDAKTDKI 363
Cdd:cd14953   291 ATSAQFNNPTGVAVD-AAGNLYVADTGNNRI 320
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 210-371 6.76e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 43.02  E-value: 6.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  210 HAIAIDYDpveGYVYWTDDEVRAIR-----RSFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEV-TRLNG 283
Cdd:cd14957    21 RGIAVDSA---GNIYVADTGNNRIQvftssGVYSYSIGSGGTGSGQFNSPYGIAVD-SNGNIYVADTDNNRIQVfNSSGV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  284 TMRKI----LISEDLEEPRAIVLDPmAGYMYWTDwgeipkieraalDGSDRVVLVNTS----------------LGWPNG 343
Cdd:cd14957    97 YQYSIgtggSGDGQFNGPYGIAVDS-NGNIYVAD------------TGNHRIQVFTSSgtfsysigsggtgpgqFNGPQG 163

                         170       180
                  ....*....|....*....|....*...
gi 157823966  344 LALDYDeGTIYWGDAKTDKIEVMNTDGT 371
Cdd:cd14957   164 IAVDSD-GNIYVADTGNHRIQVFTSSGT 190
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 221-261 6.94e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 6.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   221 GYVYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 261
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 520-664 7.24e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.08  E-value: 7.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  520 VTD---NRIYWTDISLKTISRAfmnGSALEHVVEFglDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQhrQVLVWKD- 595
Cdd:cd05819   117 VADtgnHRIQKFDPDGEFLTTF---GSGGSGPGQF--NGPTGVAVDSDG-NIYVADTGNHRIQVFDPDGN--FLTTFGSt 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  596 ------LDSPRALALDPaEGFMYWTEWGGKpKIDRAAMDGSERTTLVPNVGRAN------GLTIDyAKRRLYWTDLDTNL 663
Cdd:cd05819   189 gtgpgqFNYPTGIAVDS-DGNIYVADSGNN-RVQVFDPDGAGFGGNGNFLGSDGqfnrpsGLAVD-SDGNLYVADTGNNR 265


                  .
gi 157823966  664 I 664
Cdd:cd05819   266 I 266
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 552-665 7.62e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.04  E-value: 7.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  552 GLDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGqhRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGKpKIDR 624
Cdd:cd14956   152 SFNYPRGVAVDPDG-TLYVADTYNDRIQVFDNDG--AFLRKWggrgtgpGQFNYPYGIAIDPD-GNVFVADFGNN-RIQK 226

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 157823966  625 AAMDGSERTTlVPNVGRANG-------LTIDyAKRRLYWTDLDTNLIE 665
Cdd:cd14956   227 FTADGTFLTS-WGSPGTGPGqfknpwgVVVD-ADGTVYVADSNNNRVQ 272
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 918-959 9.33e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 9.33e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966   918 GYMYFTNLQERsPKIERAALDGTEREVLFFSGLSKPVALALD 959
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 43-83 1.09e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 1.09e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157823966    43 RKLYWADAKLNF-IHKSNLDGTNRQAVVKGSLPHPFALTLFE 83
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 516-605 1.42e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.89  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  516 LDFDVTDNRIYWTDISLKTIsRAFMNGSalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH 587
Cdd:cd14963    13 MGVAVSDGRIYVADTNNHRV-QVFDYEG--KFKKSFGgpgtgpgeFKYPYGIAVDSDG-NIYVADLYNGRIQVFDPDGKF 88

                          90       100
                  ....*....|....*....|..
gi 157823966  588 RQVLVWKD----LDSPRALALD 605
Cdd:cd14963    89 LKYFPEKKdrvkLISPAGLAID 110
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 66-100 1.66e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 1.66e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 157823966     66 QAVVKGSLPHP--FALTLFEDTLYWTDWNTHSILACN 100
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 514-606 1.84e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  514 SALDFDvTDNRIYWTDISLKTISRAFMNGSALEHVVEFG-----LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQHr 588
Cdd:cd05819    58 AGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGGSGdgdgeFNGPRGIAVDSSG-NIYVADTGNHRIQKFDPDGEF- 134

                          90       100
                  ....*....|....*....|....*
gi 157823966  589 qVLVWK-------DLDSPRALALDP 606
Cdd:cd05819   135 -LTTFGsggsgpgQFNGPTGVAVDS 158
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 12-276 2.09e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966   12 IERAGMDGSSrfviiNTEIYWPNGLTLDYEERkLYWADAKLNFIHKSNLDGTNRQAVVK-----GSLPHPFALTL-FEDT 85
Cdd:cd05819    41 ITSFGSFGSG-----DGQFNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNFLASFGGsgdgdGEFNGPRGIAVdSSGN 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966   86 LYWTDWNTHSILACNKyTGEGLREIHSNIF------SPMDIhafsqqrqpnATNPCGI----DNGGCShlclmspVKPFY 155
Cdd:cd05819   115 IYVADTGNHRIQKFDP-DGEFLTTFGSGGSgpgqfnGPTGV----------AVDSDGNiyvaDTGNHR-------IQVFD 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  156 qcacPTGVKLLESGKTCKDGAtellllarrtdlrriSLDTPdftdivlqledirHAIAIDYDpveGYVYWTDDEVRAIRR 235
Cdd:cd05819   177 ----PDGNFLTTFGSTGTGPG---------------QFNYP-------------TGIAVDSD---GNIYVADSGNNRVQV 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 157823966  236 -----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRI 276
Cdd:cd05819   222 fdpdgAGFGGNGNFLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
188-276 2.51e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  188 LRRISLDTPDFTDIVLQLEDIR-HAIAIDYDpveGYVYWTDDEVRAIRRsfID---GSGSQFVVTAQIAHPDGIAVDwVA 263
Cdd:COG4257   168 IGRIDPDTGTLTEYALPTPGAGpRGLAVDPD---GNLWVADTGSGRIGR--FDpktGTVTEYPLPGGGARPYGVAVD-GD 241

                          90
                  ....*....|...
gi 157823966  264 RNLYWTDTGTDRI 276
Cdd:COG4257   242 GRVWFAESGANRI 254
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
491-664 2.80e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  491 IRRISLETNN-NNVAIPlTGVKEASALDFDVtDNRIYWTDISLKTISR---AfmNGSALEHVVEFGLDYPEGMAVDWLGk 566
Cdd:COG4257    82 IGRIDPKTGEiTTFALP-GGGSNPHGIAFDP-DGNLWFTDQGGNRIGRldpA--TGEVTEFPLPTGGAGPYGIAVDPDG- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  567 NLYWADTGTNRI-EVSKLDGQHRQVLVWKDLDSPRALALDPaEGFMYWTEWGGKP--KIDRAamDGSERT-TLVPNVGRA 642
Cdd:COG4257   157 NLWVTDFGANAIgRIDPDTGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGSGRigRFDPK--TGTVTEyPLPGGGARP 233

                         170       180
                  ....*....|....*....|..
gi 157823966  643 NGLTIDyAKRRLYWTDLDTNLI 664
Cdd:COG4257   234 YGVAVD-GDGRVWFAESGANRI 254
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 519-606 3.02e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  519 DVTDNRIYWTDISLKTISRAFMNGsalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQHRQV 590
Cdd:cd14963   108 AIDDGKLYVSDVKKHKVIVFDLEG---KLLLEFGkpgsepgeLSYPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKFIKE 183

                          90       100
                  ....*....|....*....|.
gi 157823966  591 LVWKDLDS-----PRALALDP 606
Cdd:cd14963   184 LNGSPDGKsgfvnPRGIAVDP 204
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 899-942 3.27e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.43  E-value: 3.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157823966    899 VVLKGEQDRPRAIVVNPEKGYMYFTNLqeRSPKIERAALDGTER 942
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 964-1003 3.60e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.37  E-value: 3.60e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 157823966   964 RLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 1003
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 553-619 3.92e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.76  E-value: 3.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157823966  553 LDYPEGMAVDWLGkNLYWADTGTNRIevSKLDGQHRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGK 619
Cdd:cd05819    54 FNEPAGVAVDSDG-NLYVADTGNHRI--QKFDPDGNFLASFggsgdgdGEFNGPRGIAVDSS-GNIYVADTGNH 123
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1-22 6.15e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 6.15e-03
                            10        20
                    ....*....|....*....|..
gi 157823966      1 MYWTDWGEvPKIERAGMDGSSR 22
Cdd:smart00135   23 LYWTDWGL-DVIEVANLDGTNR 43
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 553-606 6.67e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 39.84  E-value: 6.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823966  553 LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH-----RQVLVWKDLDSPRALALDP 606
Cdd:cd14954   117 FNYPWGVAVDSEG-RIYVSDTRNHRVQVFDSDGQFirkfgFEGAGPGQLDSPRGVAVNP 174
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 850-897 7.41e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 7.41e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 157823966    850 TVVVSSVPNqnleiqPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSV 897
Cdd:smart00135    2 TLLSSGLGH------PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 254-370 7.75e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.58  E-value: 7.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823966  254 PDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKIL----ISEDLEEPRAIVLDpmAGYMYWTDWGEiPKIerAALDGSD 329
Cdd:cd14963    58 PYGIAVD-SDGNIYVADLYNGRIQVFDPDGKFLKYFpekkDRVKLISPAGLAID--DGKLYVSDVKK-HKV--IVFDLEG 131

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 157823966  330 RVVLVNTSLG-------WPNGLALDyDEGTIYWGDAKTDKIEVMNTDG 370
Cdd:cd14963   132 KLLLEFGKPGsepgelsYPNGIAVD-EDGNIYVADSGNGRIQVFDKNG 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH