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Conserved domains on  [gi|197927088|ref|NP_001102535|]
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mitochondrial translation release factor in rescue [Rattus norvegicus]

Protein Classification

peptide chain release factor family protein( domain architecture ID 10452619)

peptide chain release factor family protein such as mitochondrial translation release factor in rescue (MTRFR) that is part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation

CATH:  3.30.160.20
Gene Ontology:  GO:0003747
PubMed:  1408743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 55-116 2.29e-22

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


:

Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 86.32  E-value: 2.29e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197927088   55 LNESELEEQFVKGHGPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQEKV 116
Cdd:pfam00472   7 IDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARL 68
 
Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 55-116 2.29e-22

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 86.32  E-value: 2.29e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197927088   55 LNESELEEQFVKGHGPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQEKV 116
Cdd:pfam00472   7 IDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARL 68
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 55-116 2.88e-16

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 71.32  E-value: 2.88e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197927088  55 LNESELEEQFVKGHGPGGQATNKTSNCVVLKH------------VPSGIVVKCHQTRSVDQNRKMARKILQEKV 116
Cdd:COG1186   23 IPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALL 96
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 53-116 7.30e-11

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 59.67  E-value: 7.30e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197927088  53 LPLNESELEEQFVKGHGPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQEKV 116
Cdd:PRK08787 171 IDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKL 234
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 55-115 6.51e-10

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 55.93  E-value: 6.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197927088   55 LNESELEEQFVKGHGPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQEK 115
Cdd:TIGR03072 103 ATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVR 163
 
Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 55-116 2.29e-22

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 86.32  E-value: 2.29e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197927088   55 LNESELEEQFVKGHGPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQEKV 116
Cdd:pfam00472   7 IDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARL 68
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 55-116 2.88e-16

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 71.32  E-value: 2.88e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197927088  55 LNESELEEQFVKGHGPGGQATNKTSNCVVLKH------------VPSGIVVKCHQTRSVDQNRKMARKILQEKV 116
Cdd:COG1186   23 IPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALL 96
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 53-116 7.30e-11

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 59.67  E-value: 7.30e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197927088  53 LPLNESELEEQFVKGHGPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQEKV 116
Cdd:PRK08787 171 IDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKL 234
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 55-115 6.51e-10

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 55.93  E-value: 6.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197927088   55 LNESELEEQFVKGHGPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQEK 115
Cdd:TIGR03072 103 ATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVR 163
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 69-132 2.74e-09

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 55.20  E-value: 2.74e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197927088  69 GPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQEKVDVFYNGEnspiHKEKL 132
Cdd:PRK05589 207 GAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKLVELKERA----HKEKI 266
prfA PRK00591
peptide chain release factor 1; Validated
 69-112 2.96e-09

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 55.08  E-value: 2.96e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 197927088  69 GPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKIL 112
Cdd:PRK00591 232 GAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVL 275
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 69-113 1.81e-08

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 52.70  E-value: 1.81e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 197927088  69 GPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQ 113
Cdd:COG0216  230 GAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLR 274
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 55-116 2.11e-08

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 52.57  E-value: 2.11e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197927088  55 LNESELEEQFVKGHGPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQEKV 116
Cdd:PRK07342 196 VNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWSMLRARL 257
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
53-114 1.79e-07

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 47.84  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927088  53 LPLNESELEEQFVKGHGPGGQATNKTSNCV------------------VLKH-----VPSG-IVVKCHQTRSVDQNRKMA 108
Cdd:PRK09256   8 LVIPENELEWRFIRASGPGGQNVNKVSTAVelrfdiaasslpefykerLLALaghriTKDGvIVIKAQEFRSQERNREDA 87


                 ....*.
gi 197927088 109 RKILQE 114
Cdd:PRK09256  88 LERLVA 93
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 66-116 9.32e-06

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 44.72  E-value: 9.32e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 197927088  66 KGHGPGGQATNKTSNCVVLKHVPSGIVVKCHQTRSVDQNRKMARKILQEKV 116
Cdd:PRK06746 205 RASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKL 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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