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Conserved domains on  [gi|1146187846|ref|NP_001105478|]
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eukaryotic translation initiation factor 5 [Zea mays]

Protein Classification

eukaryotic translation initiation factor 5( domain architecture ID 10652754)

eukaryotic translation initiation factor 5 catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
15-129 1.25e-51

domain present in translation initiation factor eIF2B and eIF5;


:

Pssm-ID: 214764  Cd Length: 110  Bit Score: 169.73  E-value: 1.25e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846   15 FYRYKMPRMITKIEGRGngiKTNVVNMVDIAKALARPASYTTKYFGCELGAQSKFDEKtGISLVNGAHDTAKLAGLLEVF 94
Cdd:smart00653   1 FYRFKMPPPQVLREGKG---KTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGK-GRLIVNGRFTPKKLQDLLRRY 76

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1146187846   95 IKKYVQCYGCGNPETEILISkTQMISLKCAACGFV 129
Cdd:smart00653  77 IKEYVLCPECGSPDTELIKE-NRLFFLKCEACGAR 110
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 299-447 9.03e-42

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


:

Pssm-ID: 211399  Cd Length: 157  Bit Score: 145.45  E-value: 9.03e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846 299 SPYEELIGDIKASLGSAPtPTQLKAVLASSTLPPQdVMNALLEALFGGVGK-GFTKEVVKNKKYLAVAVPDEGAQTLLVQ 377
Cdd:cd11561     6 ERVDELGEFLKKNKDESG-LSELKEILKEAERLDV-VKDKAVLVLAEVLFDeNIVKEIKKRKALLLKLVTDEKAQKALLG 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1146187846 378 AIEAFGGKCNPEALKEVPVVLKALYDGDILDEETIVDWYNDA----VAAGKDSQVVKNAKPFVEWLQSAESDEE 447
Cdd:cd11561    84 GIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVskkyVSKEKSKKVRKAAEPFVEWLEEAEEEEE 157
 
Name Accession Description Interval E-value
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
15-129 1.25e-51

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 169.73  E-value: 1.25e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846   15 FYRYKMPRMITKIEGRGngiKTNVVNMVDIAKALARPASYTTKYFGCELGAQSKFDEKtGISLVNGAHDTAKLAGLLEVF 94
Cdd:smart00653   1 FYRFKMPPPQVLREGKG---KTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGK-GRLIVNGRFTPKKLQDLLRRY 76

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1146187846   95 IKKYVQCYGCGNPETEILISkTQMISLKCAACGFV 129
Cdd:smart00653  77 IKEYVLCPECGSPDTELIKE-NRLFFLKCEACGAR 110
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
 13-127 1.64e-46

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 156.52  E-value: 1.64e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846  13 DAFYRYKMPRMITKIEGRGngiKTNVVNMVDIAKALARPASYTTKYFGCELGAQSKFDEKtGISLVNGAHDTAKLAGLLE 92
Cdd:pfam01873   4 DSFYRYKMPPPQVKREGKG---KTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSIDEN-GRLIINGKFSAKQIEDLLD 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1146187846  93 VFIKKYVQCYGCGNPETEiLISKTQMISLKCAACG 127
Cdd:pfam01873  80 KYIEEYVLCPECGSPDTE-LIKENRLLFLKCEACG 113
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 299-447 9.03e-42

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 145.45  E-value: 9.03e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846 299 SPYEELIGDIKASLGSAPtPTQLKAVLASSTLPPQdVMNALLEALFGGVGK-GFTKEVVKNKKYLAVAVPDEGAQTLLVQ 377
Cdd:cd11561     6 ERVDELGEFLKKNKDESG-LSELKEILKEAERLDV-VKDKAVLVLAEVLFDeNIVKEIKKRKALLLKLVTDEKAQKALLG 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1146187846 378 AIEAFGGKCNPEALKEVPVVLKALYDGDILDEETIVDWYNDA----VAAGKDSQVVKNAKPFVEWLQSAESDEE 447
Cdd:cd11561    84 GIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVskkyVSKEKSKKVRKAAEPFVEWLEEAEEEEE 157
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
359-442 2.12e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 101.60  E-value: 2.12e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846  359 KKYLAVAVPDEGAQTLLVQAIEAFGGKCNPeALKEVPVVLKALYDGDILDEETIVDWYNDAVAAGKDSQVVKNAKPFVEW 438
Cdd:smart00515   1 GPLLKFLAKDEEEQLELLYAIEEFCVELEK-LGKLLPKILKSLYDADILEEEAILKWYEKAVSAEGKKKVRKNAKPFVTW 79


                   ....
gi 1146187846  439 LQSA 442
Cdd:smart00515  80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 375-447 6.81e-21

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 86.04  E-value: 6.81e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1146187846 375 LVQAIEAFGGKcNPEALKEVPVVLKALYDGDILDEETIVDWYNDAVAA-GKDSQVVKNAKPFVEWLQSAESDEE 447
Cdd:pfam02020   4 LLLALQEFCAK-LEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAeKGMKKVRKQAKPFVEWLEEAEEESD 76
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
 17-127 3.18e-13

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 66.38  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846  17 RYKMPRMITKIEGRgngiKTNVVNMVDIAKALARPASYTTKYFGCELGAQSKFDektGISLV-NGAHDTAKLAGLLEVFI 95
Cdd:COG1601    24 RFEVPEPEVRIEGN----RTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIE---GGRAIlQGKFSPEDINALIDRYV 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1146187846  96 KKYVQCYGCGNPETEiLISKTQMISLKCAACG 127
Cdd:COG1601    97 KEYVICPECGSPDTR-LVKEGRVLMLKCEACG 127
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
 17-127 4.98e-13

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 66.09  E-value: 4.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846  17 RYKMPRMITKIEGRgngiKTNVVNMVDIAKALARPASYTTKYFGCELGAQSKFDEktGISLVNGAHDTAKLAGLLEVFIK 96
Cdd:PRK03988   27 RFEVPKPDVRIEGN----RTIIRNFKEIADRLNRDPKHVAKFLLKELGTAGNIEG--GRLILQGKFSPRVINEKIDRYVK 100

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1146187846  97 KYVQCYGCGNPETEiLISKTQMISLKCAACG 127
Cdd:PRK03988  101 EYVICPECGSPDTK-LIKEGRIWVLKCEACG 130
 
Name Accession Description Interval E-value
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
15-129 1.25e-51

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 169.73  E-value: 1.25e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846   15 FYRYKMPRMITKIEGRGngiKTNVVNMVDIAKALARPASYTTKYFGCELGAQSKFDEKtGISLVNGAHDTAKLAGLLEVF 94
Cdd:smart00653   1 FYRFKMPPPQVLREGKG---KTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGK-GRLIVNGRFTPKKLQDLLRRY 76

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1146187846   95 IKKYVQCYGCGNPETEILISkTQMISLKCAACGFV 129
Cdd:smart00653  77 IKEYVLCPECGSPDTELIKE-NRLFFLKCEACGAR 110
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
 13-127 1.64e-46

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 156.52  E-value: 1.64e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846  13 DAFYRYKMPRMITKIEGRGngiKTNVVNMVDIAKALARPASYTTKYFGCELGAQSKFDEKtGISLVNGAHDTAKLAGLLE 92
Cdd:pfam01873   4 DSFYRYKMPPPQVKREGKG---KTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSIDEN-GRLIINGKFSAKQIEDLLD 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1146187846  93 VFIKKYVQCYGCGNPETEiLISKTQMISLKCAACG 127
Cdd:pfam01873  80 KYIEEYVLCPECGSPDTE-LIKENRLLFLKCEACG 113
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 299-447 9.03e-42

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 145.45  E-value: 9.03e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846 299 SPYEELIGDIKASLGSAPtPTQLKAVLASSTLPPQdVMNALLEALFGGVGK-GFTKEVVKNKKYLAVAVPDEGAQTLLVQ 377
Cdd:cd11561     6 ERVDELGEFLKKNKDESG-LSELKEILKEAERLDV-VKDKAVLVLAEVLFDeNIVKEIKKRKALLLKLVTDEKAQKALLG 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1146187846 378 AIEAFGGKCNPEALKEVPVVLKALYDGDILDEETIVDWYNDA----VAAGKDSQVVKNAKPFVEWLQSAESDEE 447
Cdd:cd11561    84 GIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVskkyVSKEKSKKVRKAAEPFVEWLEEAEEEEE 157
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
359-442 2.12e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 101.60  E-value: 2.12e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846  359 KKYLAVAVPDEGAQTLLVQAIEAFGGKCNPeALKEVPVVLKALYDGDILDEETIVDWYNDAVAAGKDSQVVKNAKPFVEW 438
Cdd:smart00515   1 GPLLKFLAKDEEEQLELLYAIEEFCVELEK-LGKLLPKILKSLYDADILEEEAILKWYEKAVSAEGKKKVRKNAKPFVTW 79


                   ....
gi 1146187846  439 LQSA 442
Cdd:smart00515  80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 375-447 6.81e-21

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 86.04  E-value: 6.81e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1146187846 375 LVQAIEAFGGKcNPEALKEVPVVLKALYDGDILDEETIVDWYNDAVAA-GKDSQVVKNAKPFVEWLQSAESDEE 447
Cdd:pfam02020   4 LLLALQEFCAK-LEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAeKGMKKVRKQAKPFVEWLEEAEEESD 76
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 368-447 3.28e-14

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 70.37  E-value: 3.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846 368 DEGAQTLLVQAIEAFggkC--NPEALKEVPVVLKALYDGDILDEETIVDWYN--DAVAAGKDSQVVKNAKPFVEWLQSAE 443
Cdd:cd11558    89 SQDDQVELLLALEEF---CleSEEGGPLFAKLLHALYDLDILEEEAILEWWEepDAGADEEMKKVRELVKKFIEWLEEAE 165


                  ....
gi 1146187846 444 SDEE 447
Cdd:cd11558   166 EESD 169
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
 17-127 3.18e-13

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 66.38  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846  17 RYKMPRMITKIEGRgngiKTNVVNMVDIAKALARPASYTTKYFGCELGAQSKFDektGISLV-NGAHDTAKLAGLLEVFI 95
Cdd:COG1601    24 RFEVPEPEVRIEGN----RTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIE---GGRAIlQGKFSPEDINALIDRYV 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1146187846  96 KKYVQCYGCGNPETEiLISKTQMISLKCAACG 127
Cdd:COG1601    97 KEYVICPECGSPDTR-LVKEGRVLMLKCEACG 127
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
 17-127 4.98e-13

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 66.09  E-value: 4.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846  17 RYKMPRMITKIEGRgngiKTNVVNMVDIAKALARPASYTTKYFGCELGAQSKFDEktGISLVNGAHDTAKLAGLLEVFIK 96
Cdd:PRK03988   27 RFEVPKPDVRIEGN----RTIIRNFKEIADRLNRDPKHVAKFLLKELGTAGNIEG--GRLILQGKFSPRVINEKIDRYVK 100

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1146187846  97 KYVQCYGCGNPETEiLISKTQMISLKCAACG 127
Cdd:PRK03988  101 EYVICPECGSPDTK-LIKEGRIWVLKCEACG 130
PRK12336 PRK12336
translation initiation factor IF-2 subunit beta; Provisional
 17-127 1.30e-10

translation initiation factor IF-2 subunit beta; Provisional


Pssm-ID: 183451 [Multi-domain]  Cd Length: 201  Bit Score: 60.73  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846  17 RYKMPRMITKIEGrgngiKTNVV-NMVDIAKALARPASYTTKYFGCELGAQSKFDEKTGIslVNGAHDTAKLAGLLEVFI 95
Cdd:PRK12336   23 RFSIPEPKIFIEG-----KTTILtNFGEIADALNRDPDHLMKFLQRELGTAGKIEGGRAV--FNGKFTEEDIQAAIDAYV 95

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1146187846  96 KKYVQCYGCGNPETEiLISKTQMISLKCAACG 127
Cdd:PRK12336   96 DEYVICSECGLPDTR-LVKEDRVLMLRCDACG 126
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 371-445 6.25e-10

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 58.38  E-value: 6.25e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1146187846 371 AQTLLVQAIEAFggkC--NPEALKEVPVVLKALYDGDILDEETIVDWYNDAVAAGKDSQVVKNAKPFVEWLQSAESD 445
Cdd:cd11560   121 AELALLNKIQEY---CyeNMKFMKVFQKIVKLLYKADVLSEDAILKWYKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 332-416 5.44e-05

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 42.85  E-value: 5.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1146187846 332 PQDVMNALLEALFGG--VGKGFTKEVVKNKKYLAVAV-PDEGAQTLLVQAIEAF-GGKCNPEALKEVPVVLKALYDGDIL 407
Cdd:cd11473    47 LTAVVNAVESADSISltQKEQLVLVLKKYGPVLRELLkLIKKDQLYLLLKIEKLcLQLKLSELISLLEKILDLLYDADVL 126


                  ....*....
gi 1146187846 408 DEETIVDWY 416
Cdd:cd11473   127 SEEAILSWF 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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