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Conserved domains on  [gi|164448596|ref|NP_001106731|]
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reticulon-2 isoform B [Bos taurus]

Protein Classification

reticulon family protein( domain architecture ID 10493657)

reticulon family protein associates with the endoplasmic reticulum (ER) through a C-terminal di-lysine ER retention motif; such as mammalian RTN4/Nogo, a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching

Gene Ontology:  GO:0005789|GO:0005783
PubMed:  12832288|18177508|22425683|33924890

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 270-434 2.14e-47

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


:

Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 160.73  E-value: 2.14e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  270 VVDLLHWKDAKTSGVVFTCLMVSLLSL--LHFSIVSVAAHVALLLLCGTISLRVYRKVLQAVhrgdgANPFQayldvDLT 347
Cdd:pfam02453   1 VADLLLWRNPKKSGGVFGGATALWLLFevLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRP-----PPPIP-----ELE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  348 LTQEQTERLSQQIASRVVSAAIQLRHFFLVEDLVDSLKLALLFYILTFVGAVFNGLTLLILGVIGVFTVPLLYRQHQAQI 427
Cdd:pfam02453  71 LSEETVRELADSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEI 150


                  ....*..
gi 164448596  428 DQYVGLV 434
Cdd:pfam02453 151 DAYVEKA 157
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 74-255 1.66e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   74 GSGARRDSAARRPRPQG--------RSVSEPRDPPPQP-------GLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPPE 138
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAarptvgslTSLADPPPPPPTPepaphalVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT 2750

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  139 DLGLQLDQLGWATRGAGTGEDSATSSSTPLED-EEPEGSVAGEAGKELDLP-----LAFVQSSPLEVFTPQPSPVSGIPQ 212
Cdd:PHA03247 2751 PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRlTRPAVASLSESRESLPSPwdpadPPAAVLAPAAALPPAASPAGPLPP 2830

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 164448596  213 TPTPSPPRSRDSNSWLDEPLPDEKEEEPWGQLEREPITGQCLA 255
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAA 2873
 
Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 270-434 2.14e-47

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 160.73  E-value: 2.14e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  270 VVDLLHWKDAKTSGVVFTCLMVSLLSL--LHFSIVSVAAHVALLLLCGTISLRVYRKVLQAVhrgdgANPFQayldvDLT 347
Cdd:pfam02453   1 VADLLLWRNPKKSGGVFGGATALWLLFevLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRP-----PPPIP-----ELE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  348 LTQEQTERLSQQIASRVVSAAIQLRHFFLVEDLVDSLKLALLFYILTFVGAVFNGLTLLILGVIGVFTVPLLYRQHQAQI 427
Cdd:pfam02453  71 LSEETVRELADSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEI 150


                  ....*..
gi 164448596  428 DQYVGLV 434
Cdd:pfam02453 151 DAYVEKA 157
PHA03247 PHA03247
large tegument protein UL36; Provisional
 74-255 1.66e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   74 GSGARRDSAARRPRPQG--------RSVSEPRDPPPQP-------GLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPPE 138
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAarptvgslTSLADPPPPPPTPepaphalVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT 2750

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  139 DLGLQLDQLGWATRGAGTGEDSATSSSTPLED-EEPEGSVAGEAGKELDLP-----LAFVQSSPLEVFTPQPSPVSGIPQ 212
Cdd:PHA03247 2751 PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRlTRPAVASLSESRESLPSPwdpadPPAAVLAPAAALPPAASPAGPLPP 2830

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 164448596  213 TPTPSPPRSRDSNSWLDEPLPDEKEEEPWGQLEREPITGQCLA 255
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAA 2873
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 17-233 2.74e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.41  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   17 TASSTPDSTEGGNDDSDFRELHTAREFSEDDEEETTSQDWGTPRELTFSyiafdgVVGSGARRDSAARRPRPQGRSVSEP 96
Cdd:pfam17823  95 TDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFS------APRAAACRANASAAPRAAIAAASAP 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   97 RDPPPQPGLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPPEdlglqldqlGWATRGAGTGEDSATSSSTPLEDEEP-EG 175
Cdd:pfam17823 169 HAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPAR---------GISTAATATGHPAAGTALAAVGNSSPaAG 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 164448596  176 SVAGEAGKELDLPLAFVQSSPLEVFTPQPSPVSGIPQTPTPSPPRSRDSNSWLDEPLP 233
Cdd:pfam17823 240 TVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAA 297
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 114-219 1.54e-03

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 40.93  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596 114 SLSQSPEPGRRGDPSSAPPAERPP-------EDLGLQLDQLGWATRGAGTGEDSATSSSTPLEDEEPEGSVAGEAGKELD 186
Cdd:COG5028   22 SSKKSARPHRAYANFSAGQMGMPPyttpplqQQSRRQIDQAATAMHNTGANNPAPSVMSPAFQSQQKFSSPYGGSMADGT 101

                         90       100       110
                 ....*....|....*....|....*....|...
gi 164448596 187 LPLAFVQSSPLEVFTPQPSPVSGIPQTPTPSPP 219
Cdd:COG5028  102 APKPTNPLVPVDLFEDQPPPISDLFLPPPPIVP 134
 
Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 270-434 2.14e-47

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 160.73  E-value: 2.14e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  270 VVDLLHWKDAKTSGVVFTCLMVSLLSL--LHFSIVSVAAHVALLLLCGTISLRVYRKVLQAVhrgdgANPFQayldvDLT 347
Cdd:pfam02453   1 VADLLLWRNPKKSGGVFGGATALWLLFevLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRP-----PPPIP-----ELE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  348 LTQEQTERLSQQIASRVVSAAIQLRHFFLVEDLVDSLKLALLFYILTFVGAVFNGLTLLILGVIGVFTVPLLYRQHQAQI 427
Cdd:pfam02453  71 LSEETVRELADSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEI 150


                  ....*..
gi 164448596  428 DQYVGLV 434
Cdd:pfam02453 151 DAYVEKA 157
PHA03247 PHA03247
large tegument protein UL36; Provisional
 74-255 1.66e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   74 GSGARRDSAARRPRPQG--------RSVSEPRDPPPQP-------GLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPPE 138
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAarptvgslTSLADPPPPPPTPepaphalVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT 2750

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  139 DLGLQLDQLGWATRGAGTGEDSATSSSTPLED-EEPEGSVAGEAGKELDLP-----LAFVQSSPLEVFTPQPSPVSGIPQ 212
Cdd:PHA03247 2751 PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRlTRPAVASLSESRESLPSPwdpadPPAAVLAPAAALPPAASPAGPLPP 2830

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 164448596  213 TPTPSPPRSRDSNSWLDEPLPDEKEEEPWGQLEREPITGQCLA 255
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAA 2873
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 15-222 2.37e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   15 PSTASSTPDSTEGGNDDSDFRelhtaREFSEDDEEETTSQDWGT-PRELTfsyiafdgvVGSGARRDSAARRPRPQGRSV 93
Cdd:PHA03307  211 SPISASASSPAPAPGRSAADD-----AGASSSDSSSSESSGCGWgPENEC---------PLPRPAPITLPTRIWEASGWN 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   94 SEPRDPPPQPglgdSLESIPSLSQSPEPGRRGDPSSAPPAeRPPEDLGLQLDQLGWATRGAGTGEDSATSSSTPLEDEEP 173
Cdd:PHA03307  277 GPSSRPGPAS----SSSSPRERSPSPSPSSPGSGPAPSSP-RASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSP 351

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 164448596  174 EGSvageagkelDLPLAFVQSSPlevftPQPSPVSGIPQTPTPSPPRSR 222
Cdd:PHA03307  352 SPS---------RPPPPADPSSP-----RKRPRPSRAPSSPAASAGRPT 386
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 17-233 2.74e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.41  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   17 TASSTPDSTEGGNDDSDFRELHTAREFSEDDEEETTSQDWGTPRELTFSyiafdgVVGSGARRDSAARRPRPQGRSVSEP 96
Cdd:pfam17823  95 TDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFS------APRAAACRANASAAPRAAIAAASAP 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   97 RDPPPQPGLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPPEdlglqldqlGWATRGAGTGEDSATSSSTPLEDEEP-EG 175
Cdd:pfam17823 169 HAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPAR---------GISTAATATGHPAAGTALAAVGNSSPaAG 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 164448596  176 SVAGEAGKELDLPLAFVQSSPLEVFTPQPSPVSGIPQTPTPSPPRSRDSNSWLDEPLP 233
Cdd:pfam17823 240 TVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAA 297
PHA03247 PHA03247
large tegument protein UL36; Provisional
 73-221 4.92e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 4.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   73 VGSGARRDSAARRPrPQGRSVSEPRDPPPQPGLGDSLESIPSLSQSPEPGRR--------GDPSSAPPAERPPEDLGLQL 144
Cdd:PHA03247 2582 VTSRARRPDAPPQS-ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSpaanepdpHPPPTVPPPERPRDDPAPGR 2660

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 164448596  145 DQLGWATRGAGtgedSATSSSTPLEDEEPEGSVAGEAgkeldlPLAFVQSSPLEVFTPQPSPVSGIPQTPTPSPPRS 221
Cdd:PHA03247 2661 VSRPRRARRLG----RAAQASSPPQRPRRRAARPTVG------SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA 2727
PHA03247 PHA03247
large tegument protein UL36; Provisional
 58-227 7.75e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 7.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   58 TPRELTFSYIAFDGVVGSG---ARRDSA-------ARRPRPQGRSVSEP---RDPPPQPGLGDSLESIPSlSQSPEPGRR 124
Cdd:PHA03247 2841 PPPGPPPPSLPLGGSVAPGgdvRRRPPSrspaakpAAPARPPVRRLARPavsRSTESFALPPDQPERPPQ-PQAPPPPQP 2919

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  125 GDPSSAPPAERPPEDLGLQLDqlgwatrgagtgedsatSSSTPLEDEEPEGSVAGEAGKELDLPLAFVQSSPLEVFTPQP 204
Cdd:PHA03247 2920 QPQPPPPPQPQPPPPPPPRPQ-----------------PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQP 2982

                         170       180
                  ....*....|....*....|....*
gi 164448596  205 SPVSGIPQTPTPSPPRSRDS--NSW 227
Cdd:PHA03247 2983 APSREAPASSTPPLTGHSLSrvSSW 3007
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 81-234 1.54e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   81 SAARRPRPQGRSVSEPRDPPPQPGLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPPEDLGLQLDqlgwaTRGAGTGEDS 160
Cdd:PHA03307   75 PGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLR-----PVGSPGPPPA 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 164448596  161 ATSSSTPLEDEEPEGSVAGeaGKELDLPLAFVQSSPLEVFTPQPSPVSGIPQTPTPSPPRSRDSNSWLDEPLPD 234
Cdd:PHA03307  150 ASPPAAGASPAAVASDAAS--SRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPA 221
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 114-219 1.54e-03

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 40.93  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596 114 SLSQSPEPGRRGDPSSAPPAERPP-------EDLGLQLDQLGWATRGAGTGEDSATSSSTPLEDEEPEGSVAGEAGKELD 186
Cdd:COG5028   22 SSKKSARPHRAYANFSAGQMGMPPyttpplqQQSRRQIDQAATAMHNTGANNPAPSVMSPAFQSQQKFSSPYGGSMADGT 101

                         90       100       110
                 ....*....|....*....|....*....|...
gi 164448596 187 LPLAFVQSSPLEVFTPQPSPVSGIPQTPTPSPP 219
Cdd:COG5028  102 APKPTNPLVPVDLFEDQPPPISDLFLPPPPIVP 134
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 75-240 1.58e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   75 SGARRDSAARRPRPQGRSV-------SEPRDPPPQPGLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPP----EDLGLQ 143
Cdd:PHA03307  135 SEMLRPVGSPGPPPAASPPaagaspaAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPrpprRSSPIS 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  144 LDQLGWATRGAGTGEDSA---TSSSTPLEDEEPEGSVAGEAGKEL----DLPLAFVQSSP--LEVFTPQPSPVSGIPQTP 214
Cdd:PHA03307  215 ASASSPAPAPGRSAADDAgasSSDSSSSESSGCGWGPENECPLPRpapiTLPTRIWEASGwnGPSSRPGPASSSSSPRER 294

                         170       180
                  ....*....|....*....|....*.
gi 164448596  215 TPSPPRSRDSNSWLDEPLPDEKEEEP 240
Cdd:PHA03307  295 SPSPSPSSPGSGPAPSSPRASSSSSS 320
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 74-248 1.67e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  74 GSGARRDSAARRPRPQGRSVSEPRDPPPQPGLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPPEdlglQLDQLGWATRG 153
Cdd:PRK07764 635 APAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPA----QPAPAPAATPP 710

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596 154 AGTGEDSATSSSTPLEDEEPEGSVAGEAGKELDLPLAFVQSSPLEVFTPQPSPVSGIPQTPTPSPPRSRDSnswlDEPLP 233
Cdd:PRK07764 711 AGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSE----EEEMA 786

                        170
                 ....*....|....*
gi 164448596 234 DEKEEEPWGQLEREP 248
Cdd:PRK07764 787 EDDAPSMDDEDRRDA 801
dnaA PRK14086
chromosomal replication initiator protein DnaA;
77-222 2.58e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 40.19  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  77 ARRDSAARRPRPQGRSV---------SEPRDPPPQPGLGDSLESIPSLSQSPEPG--------------RRGDPSSAPPA 133
Cdd:PRK14086 102 ARRTSEPELPRPGRRPYegyggpradDRPPGLPRQDQLPTARPAYPAYQQRPEPGawpraaddygwqqqRLGFPPRAPYA 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596 134 E-----------RPPEDLGLQLDQLGWAT-RGAGTGEDSATSSSTPLEDEEPEgsvAGEAGKELDLPLAFVQSSPLEVFT 201
Cdd:PRK14086 182 SpasyapeqerdREPYDAGRPEYDQRRRDyDHPRPDWDRPRRDRTDRPEPPPG---AGHVHRGGPGPPERDDAPVVPIRP 258

                        170       180
                 ....*....|....*....|..
gi 164448596 202 PQPSPVSGIPQ-TPTPSPPRSR 222
Cdd:PRK14086 259 SAPGPLAAQPApAPGPGEPTAR 280
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 13-182 4.03e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 4.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  13 EAPSTASSTPDSTEGGNDDSDFRELHTAREFSEDDEEETTSQDWGTPRELTFSYIAFDGVVGSGARRDSAARRPRPQGRS 92
Cdd:PRK07764 622 AAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQP 701

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  93 VSEPRDPPPQPGLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPPEDLGLQLDQLGWATRGAGTGEDSATSSSTPLEDEE 172
Cdd:PRK07764 702 APAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSE 781

                        170
                 ....*....|
gi 164448596 173 PEGSVAGEAG 182
Cdd:PRK07764 782 EEEMAEDDAP 791
PHA03169 PHA03169
hypothetical protein; Provisional
 12-240 4.60e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 39.18  E-value: 4.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  12 KEAPSTASSTPDSTEGGnDDSDFRELHTAREFSEDDEEETTSQDWGTPREltfsyiaFDGVVGSGARRDSAARRPRPQGR 91
Cdd:PHA03169  39 TAARAAKPAPPAPTTSG-PQVRAVAEQGHRQTESDTETAEESRHGEKEER-------GQGGPSGSGSESVGSPTPSPSGS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  92 SVSEPRDPPPQPGLGDSLES------IPSLSQSPEPGRRGDPSSAPPAERPPEDLGLQldqlgwatrgaGTGEDSATSSS 165
Cdd:PHA03169 111 AEELASGLSPENTSGSSPESpashspPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQ-----------PSHEDSPEEPE 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 164448596 166 TPLEDEEPEGSVAGEAgkeldlplafvqSSPLEVFTPQPSPVS-GIPQTPTPS---PPRSRDSNSWLDEPLPDEKEEEP 240
Cdd:PHA03169 180 PPTSEPEPDSPGPPQS------------ETPTSSPPPQSPPDEpGEPQSPTPQqapSPNTQQAVEHEDEPTEPEREGPP 246
PHA03378 PHA03378
EBNA-3B; Provisional
 77-256 6.00e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 39.28  E-value: 6.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  77 ARRDSAARRPRPQGRSVSEPRDPPPQPGLGDSLESIPSLSQSPEPGRRGDPSS------APPAERPPEDLGLQLDQLGWA 150
Cdd:PHA03378 754 ARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSmqlmprAAPGQQGPTKQILRQLLTGGV 833

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596 151 TRG------AGTGEDSATSSSTPledeEPEGsvaGEAGKELDLPLAFVQSS-----PLEVFTPQPSPVSGIPQTPTPSPP 219
Cdd:PHA03378 834 KRGrpslkkPAALERQAAAGPTP----SPGS---GTSDKIVQAPVFYPPVLqpiqvMRQLGSVRAAAASTVTQAPTEYTG 906

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 164448596 220 RSRDSNSWLDEPLPDEKEEEPWGQLEREPITGQCLAS 256
Cdd:PHA03378 907 ERRGVGPMHPTDIPPSKRAKTDAYVESQPPHGGQSHS 943
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 68-242 6.09e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.20  E-value: 6.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  68 AFDGVVGSGArrdSAARRPRPQGRSVSEPRDPPPQPGLGDSlesiPSLSQSPEPGRRGDPSSAPPAERPPEDLGLQLDQL 147
Cdd:PRK07764 583 QVEAVVGPAP---GAAGGEGPPAPASSGPPEEAARPAAPAA----PAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPK 655

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596 148 GWATRGAGTGEDSATSSSTPLEDEEPEGSVAGEAGkeldlPLAFVQSSPLEVFTPQPSPVSGIPQTPTPSPPR------S 221
Cdd:PRK07764 656 HVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAP-----AAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQaaqgasA 730

                        170       180
                 ....*....|....*....|.
gi 164448596 222 RDSNSWLDEPLPDEKEEEPWG 242
Cdd:PRK07764 731 PSPAADDPVPLPPEPDDPPDP 751
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 74-243 7.55e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 7.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596  74 GSGARRDSAARRPRPQGRSVSEPRDPPPQPGLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPPEDLGLQLDQLGWATRG 153
Cdd:PRK07764 603 PASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPP 682

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596 154 AGTGEDSATSSSTPLEDEEPEGSVAGEAGKELDLPLAFVQSSPLEVFTPQPSPVSGIPQTPTPSPPRSRDSNSWLDEPLP 233
Cdd:PRK07764 683 PAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPP 762

                        170
                 ....*....|
gi 164448596 234 DEKEEEPWGQ 243
Cdd:PRK07764 763 APAPAAAPAA 772
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 89-219 9.14e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.59  E-value: 9.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164448596   89 QGRSVSEPRDPPPQPGLGDSLESIPSLSQSPEPGRRGDPSSAPPAERPPEDLGLQLdqlgwATRGAGTGEDSATSSSTPL 168
Cdd:pfam03154 139 QDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQA-----ATAGPTPSAPSVPPQGSPA 213

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 164448596  169 EDEEPEGSVAGEAgkeldlPLAFVQSSPLEVFTPQPSPVSGIPQTPTPSPP 219
Cdd:pfam03154 214 TSQPPNQTQSTAA------PHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPP 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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