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Conserved domains on  [gi|164664494|ref|NP_001106857|]
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leukemia inhibitory factor receptor isoform 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 126-239 1.31e-60

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


:

Pssm-ID: 375455  Cd Length: 114  Bit Score: 198.83  E-value: 1.31e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164664494  126 DVSLIPETPEILDLSADFFTSSLLLKWNDRGSALPHPSNATWEIKVLQNPRTEPVALVLLNTMLSGKDTVQHWNWTSDLP 205
Cdd:pfam17971   1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 164664494  206 LQCATHSVSIRWHIDSPHFSGYKEWSDWSPLKNI 239
Cdd:pfam17971  81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 50-124 1.76e-34

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


:

Pssm-ID: 436347  Cd Length: 78  Bit Score: 125.90  E-value: 1.76e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164664494   50 DLKCTTNNMRVWDCTWPAPLGVSPGTVKDICIKDRFHSCHPLETTNVKIPALSPGDHEVTINYLNGFQS---KFTLNE 124
Cdd:pfam18207   1 DLKCITHNLQVWDCSWDAPSGAGHGTTYEFCIENRSHSCYKTEKTNIEIPALSPGDHEITINSLSGFGSstsKFILNE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 428-525 1.70e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164664494 428 PHDPTSLKVKDINSTVVTFSWYLPGNFTKINLLCQIEICKANSKKEVrnaTIRGAEDSTYHVAVDKLNPYTAYTFRVRCs 507
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK---EVEVTPGSETSYTLTGLKPGTEYEFRVRA- 76

                         90
                 ....*....|....*...
gi 164664494 508 sKTFWKWSRWSDEKRHLT 525
Cdd:cd00063   77 -VNGGGESPPSESVTVTT 93
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 547-614 1.91e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 1.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164664494  547 LIVYWKPLPinEANGKILSYNVSCSLNEETQSVLEIFDPQHRAEIQLSK----NDYIISVVARNSAGSSPPS 614
Cdd:pfam00041  16 LTVSWTPPP--DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlkpgTEYEVRVQAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 126-239 1.31e-60

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


Pssm-ID: 375455  Cd Length: 114  Bit Score: 198.83  E-value: 1.31e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164664494  126 DVSLIPETPEILDLSADFFTSSLLLKWNDRGSALPHPSNATWEIKVLQNPRTEPVALVLLNTMLSGKDTVQHWNWTSDLP 205
Cdd:pfam17971   1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 164664494  206 LQCATHSVSIRWHIDSPHFSGYKEWSDWSPLKNI 239
Cdd:pfam17971  81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 50-124 1.76e-34

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


Pssm-ID: 436347  Cd Length: 78  Bit Score: 125.90  E-value: 1.76e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164664494   50 DLKCTTNNMRVWDCTWPAPLGVSPGTVKDICIKDRFHSCHPLETTNVKIPALSPGDHEVTINYLNGFQS---KFTLNE 124
Cdd:pfam18207   1 DLKCITHNLQVWDCSWDAPSGAGHGTTYEFCIENRSHSCYKTEKTNIEIPALSPGDHEITINSLSGFGSstsKFILNE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 428-525 1.70e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164664494 428 PHDPTSLKVKDINSTVVTFSWYLPGNFTKINLLCQIEICKANSKKEVrnaTIRGAEDSTYHVAVDKLNPYTAYTFRVRCs 507
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK---EVEVTPGSETSYTLTGLKPGTEYEFRVRA- 76

                         90
                 ....*....|....*...
gi 164664494 508 sKTFWKWSRWSDEKRHLT 525
Cdd:cd00063   77 -VNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
431-515 3.12e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.87  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164664494  431 PTSLKVKDINSTVVTFSWYLP----GNFTKINLLCQieicKANSKKEVRNATIRGaedSTYHVAVDKLNPYTAYTFRVR- 505
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPPpdgnGPITGYEVEYR----PKNSGEPWNEITVPG---TTTSVTLTGLKPGTEYEVRVQa 75

                          90
                  ....*....|
gi 164664494  506 CSSKTFWKWS 515
Cdd:pfam00041  76 VNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 431-506 2.41e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 2.41e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164664494   431 PTSLKVKDINSTVVTFSWYLP--GNFTKINLLCQIEICKANSKKEVRNATirgaeDSTYHVAVDKLNPYTAYTFRVRC 506
Cdd:smart00060   4 PSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVT-----PSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
547-614 1.91e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 1.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164664494  547 LIVYWKPLPinEANGKILSYNVSCSLNEETQSVLEIFDPQHRAEIQLSK----NDYIISVVARNSAGSSPPS 614
Cdd:pfam00041  16 LTVSWTPPP--DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlkpgTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 536-611 8.09e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.05  E-value: 8.09e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164664494   536 TWREWSSDgkNLIVYWKPLPINEANGKILSYNVSCSLNEETQSVLEIFDPQHRAEIQ-LSKN-DYIISVVARNSAGSS 611
Cdd:smart00060   8 RVTDVTST--SVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTgLKPGtEYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 126-239 1.31e-60

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


Pssm-ID: 375455  Cd Length: 114  Bit Score: 198.83  E-value: 1.31e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164664494  126 DVSLIPETPEILDLSADFFTSSLLLKWNDRGSALPHPSNATWEIKVLQNPRTEPVALVLLNTMLSGKDTVQHWNWTSDLP 205
Cdd:pfam17971   1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 164664494  206 LQCATHSVSIRWHIDSPHFSGYKEWSDWSPLKNI 239
Cdd:pfam17971  81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 50-124 1.76e-34

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


Pssm-ID: 436347  Cd Length: 78  Bit Score: 125.90  E-value: 1.76e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164664494   50 DLKCTTNNMRVWDCTWPAPLGVSPGTVKDICIKDRFHSCHPLETTNVKIPALSPGDHEVTINYLNGFQS---KFTLNE 124
Cdd:pfam18207   1 DLKCITHNLQVWDCSWDAPSGAGHGTTYEFCIENRSHSCYKTEKTNIEIPALSPGDHEITINSLSGFGSstsKFILNE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 428-525 1.70e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164664494 428 PHDPTSLKVKDINSTVVTFSWYLPGNFTKINLLCQIEICKANSKKEVrnaTIRGAEDSTYHVAVDKLNPYTAYTFRVRCs 507
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK---EVEVTPGSETSYTLTGLKPGTEYEFRVRA- 76

                         90
                 ....*....|....*...
gi 164664494 508 sKTFWKWSRWSDEKRHLT 525
Cdd:cd00063   77 -VNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
431-515 3.12e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.87  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164664494  431 PTSLKVKDINSTVVTFSWYLP----GNFTKINLLCQieicKANSKKEVRNATIRGaedSTYHVAVDKLNPYTAYTFRVR- 505
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPPpdgnGPITGYEVEYR----PKNSGEPWNEITVPG---TTTSVTLTGLKPGTEYEVRVQa 75

                          90
                  ....*....|
gi 164664494  506 CSSKTFWKWS 515
Cdd:pfam00041  76 VNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 431-506 2.41e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 2.41e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164664494   431 PTSLKVKDINSTVVTFSWYLP--GNFTKINLLCQIEICKANSKKEVRNATirgaeDSTYHVAVDKLNPYTAYTFRVRC 506
Cdd:smart00060   4 PSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVT-----PSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
547-614 1.91e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 1.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164664494  547 LIVYWKPLPinEANGKILSYNVSCSLNEETQSVLEIFDPQHRAEIQLSK----NDYIISVVARNSAGSSPPS 614
Cdd:pfam00041  16 LTVSWTPPP--DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlkpgTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 536-611 8.09e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.05  E-value: 8.09e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164664494   536 TWREWSSDgkNLIVYWKPLPINEANGKILSYNVSCSLNEETQSVLEIFDPQHRAEIQ-LSKN-DYIISVVARNSAGSS 611
Cdd:smart00060   8 RVTDVTST--SVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTgLKPGtEYEFRVRAVNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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