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Conserved domains on  [gi|167555123|ref|NP_001107875|]
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uroplakin-3b-like protein 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UP_III_II super family cl06408
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 41-211 8.72e-74

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


The actual alignment was detected with superfamily member cd09969:

Pssm-ID: 471435  Cd Length: 184  Bit Score: 223.04  E-value: 8.72e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123  41 EHISYVPQLSNDTLAGRLTLSTFTLEQPLGQFSSHniSDLDTIWLVVALSNATQSFTAPRTNQDIPAPANFSQRGYYLTL 120
Cdd:cd09969    1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSSS--SDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123 121 RANRVLY---QTRGQLHVLRVGNDTHCqpTKIGCNHPLPGPGPYRVKFLVMNDEGPVAETKWSSDTRLQQA---QALRAV 194
Cdd:cd09969   79 RASRALYpcgNPSMGLPVLRVGADTGC--TDNNCNGPLPGPGPYRVKFLVMNNRGPVAETNWSDPITLRTGkspQTIDTW 156

                        170
                 ....*....|....*..
gi 167555123 195 PGPQSPGTVVIIAILSI 211
Cdd:cd09969  157 PGRRSGGMIVITTILSV 173
 
Name Accession Description Interval E-value
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 41-211 8.72e-74

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 223.04  E-value: 8.72e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123  41 EHISYVPQLSNDTLAGRLTLSTFTLEQPLGQFSSHniSDLDTIWLVVALSNATQSFTAPRTNQDIPAPANFSQRGYYLTL 120
Cdd:cd09969    1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSSS--SDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123 121 RANRVLY---QTRGQLHVLRVGNDTHCqpTKIGCNHPLPGPGPYRVKFLVMNDEGPVAETKWSSDTRLQQA---QALRAV 194
Cdd:cd09969   79 RASRALYpcgNPSMGLPVLRVGADTGC--TDNNCNGPLPGPGPYRVKFLVMNNRGPVAETNWSDPITLRTGkspQTIDTW 156

                        170
                 ....*....|....*..
gi 167555123 195 PGPQSPGTVVIIAILSI 211
Cdd:cd09969  157 PGRRSGGMIVITTILSV 173
 
Name Accession Description Interval E-value
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 41-211 8.72e-74

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 223.04  E-value: 8.72e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123  41 EHISYVPQLSNDTLAGRLTLSTFTLEQPLGQFSSHniSDLDTIWLVVALSNATQSFTAPRTNQDIPAPANFSQRGYYLTL 120
Cdd:cd09969    1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSSS--SDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123 121 RANRVLY---QTRGQLHVLRVGNDTHCqpTKIGCNHPLPGPGPYRVKFLVMNDEGPVAETKWSSDTRLQQA---QALRAV 194
Cdd:cd09969   79 RASRALYpcgNPSMGLPVLRVGADTGC--TDNNCNGPLPGPGPYRVKFLVMNNRGPVAETNWSDPITLRTGkspQTIDTW 156

                        170
                 ....*....|....*..
gi 167555123 195 PGPQSPGTVVIIAILSI 211
Cdd:cd09969  157 PGRRSGGMIVITTILSV 173
UP_III cd09968
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a ...
 41-211 3.56e-67

Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197377  Cd Length: 187  Bit Score: 206.46  E-value: 3.56e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123  41 EHISYVPQLSNDTLAGRLTLSTFTLEQPLGQFSSHNiSDLDTIWLVVALSNATQSFTAPRTNQD-IPAPANFSQRGYYLT 119
Cdd:cd09968    1 EAVSYVPQLASTFLEGNPTSTTFTLEQPRCVFDSSA-SDTDDVWLVVAVSNATNNFNAPQNSTDpISTYSQFSGGQYYLT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123 120 LRANRVLYQ---TRGQLHVLRVGNDTHCQPtKIGCNHPLPGPGPYRVKFLVMNDEGPVAETKWSSDTRLQQA---QALRA 193
Cdd:cd09968   80 LRASRDLYPcgnPSLNAYVLRVGADGNCTD-NGNCNGPLPGPGPYRVKYLVMNGSGVVAQTNWSDPIRLNQAksyQTIDT 158

                        170
                 ....*....|....*...
gi 167555123 194 VPGPQSPGTVVIIAILSI 211
Cdd:cd09968  159 WPGRRSGGMIVITSILSV 176
UP_III_II cd09966
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 43-211 2.37e-58

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197375  Cd Length: 181  Bit Score: 183.78  E-value: 2.37e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123  43 ISYVPQLSNDTLAGRLTLSTFTLEQPLGQFSShniSDLDTIWLVVALSNATQSFTAPRTNQDIPAPANFSQRGYYLTLRA 122
Cdd:cd09966    1 LSYVPQLTASTGAGNPTLSTFTLEQPPCMFDS---SSTDDVWLVVALPNATLAFQNVTLSTDISTYLTFTTGNYYKTLRA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123 123 NRVLYQTRG-----QLHVLRVGNDTHCQPTkiGCNHPLPGPGPYRVKFLVMNDEGPVAETKWSSDTRLQQAQA-LRAVPG 196
Cdd:cd09966   78 SFDLPPCRNrrdivSAYVLRVGNTTTCLSG--YCNTPLPGPGPYRVKYLVMNGSGPSAQTEWSTPIRLNQNKIySTTWPG 155

                        170
                 ....*....|....*
gi 167555123 197 PQSPGTVVIIAILSI 211
Cdd:cd09966  156 ARSGGMIVITVILSV 170
UP_IIIa cd09970
Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is ...
 43-210 5.42e-09

Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197379  Cd Length: 212  Bit Score: 54.99  E-value: 5.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123  43 ISYVPQLSNDTLAG-RLTLSTFTLEQPLGQFSSHNISDLD-TIWLVVALSNATQSFTAPRTNQDIPAPANFSQ-----RG 115
Cdd:cd09970    3 VNLQPQLASVTFATnNPTLTTITLEKPFCMFDSKEALTGThEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQteggrTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555123 116 YYL-------------TLRANRVLYQTRGQL--HVLRVGNDTHC--QPTKIG-CNHPLPGPGPYRVKFLVMNDEGPVAE- 176
Cdd:cd09970   83 PYKaaafdlppcsdlpSLDAIGDVSKASQILnaYLVRVGANGTClwDPNFKGlCNPPLSAATEYRFKYVLVNMSTGLVEd 162

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 167555123 177 -TKWSSDTRLQQAQALRAV---PGPQSPGTVVIIAILS 210
Cdd:cd09970  163 qTLWSDPIRTNQLTPYSTIdtwPGRRSGGMIVITSILS 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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