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Conserved domains on  [gi|186505383|ref|NP_001118443|]
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Coatomer epsilon subunit [Arabidopsis thaliana]

Protein Classification

coatomer subunit epsilon( domain architecture ID 707680)

coatomer subunit epsilon, a component of the coatomer complex, which is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins

CATH:  1.25.40.10
Gene Ontology:  GO:0015031|GO:0005198|GO:0006888
SCOP:  4001344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Coatomer_E super family cl28726
Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, ...
 1-214 3.58e-123

Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex.


The actual alignment was detected with superfamily member pfam04733:

Pssm-ID: 398419 [Multi-domain]  Cd Length: 288  Bit Score: 350.24  E-value: 3.58e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383    1 MYLSTPQNKESTISSLKEWLADSTIGNNDTLRLIAGIIFMHEEDYNETLKHTHAGGTMDLYALNVQIFIKMHRAEYAEKQ 80
Cdd:pfam04733  72 EYLNSPSRKESILASLKEWVADSHIGSNSTLRLLAAIIFIHEGDFDDALKHLHKGENLEAMALNVQILLKMHRIDLAEQQ 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383   81 LRVMQQIDEDHTLTQLASAWLNLAVGGSKIQEAYLIFEDFSEKYPMTCLILNGKAVCCMQMGNFDEAETLLLEALNKDAK 160
Cdd:pfam04733 152 LKKMQQIDEDATLTQLANAWVKLAVGGEKIQDAYYIFQEFSEKYDSTPLLLNGQAVCCMCLGRYEEAESLLKEALDKDAK 231

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 186505383  161 DPETLANLVVCSLHVGK---SSSRHLSQLKLSHPEHILVKRVSSAEDNFERAVQLVA 214
Cdd:pfam04733 232 DPETLINLVVCALHLGKpaeVSNRNLSQLKLSHPTHPLVKDLNEKEAEFDRAVQQFA 288
 
Name Accession Description Interval E-value
Coatomer_E pfam04733
Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, ...
 1-214 3.58e-123

Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex.


Pssm-ID: 398419 [Multi-domain]  Cd Length: 288  Bit Score: 350.24  E-value: 3.58e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383    1 MYLSTPQNKESTISSLKEWLADSTIGNNDTLRLIAGIIFMHEEDYNETLKHTHAGGTMDLYALNVQIFIKMHRAEYAEKQ 80
Cdd:pfam04733  72 EYLNSPSRKESILASLKEWVADSHIGSNSTLRLLAAIIFIHEGDFDDALKHLHKGENLEAMALNVQILLKMHRIDLAEQQ 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383   81 LRVMQQIDEDHTLTQLASAWLNLAVGGSKIQEAYLIFEDFSEKYPMTCLILNGKAVCCMQMGNFDEAETLLLEALNKDAK 160
Cdd:pfam04733 152 LKKMQQIDEDATLTQLANAWVKLAVGGEKIQDAYYIFQEFSEKYDSTPLLLNGQAVCCMCLGRYEEAESLLKEALDKDAK 231

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 186505383  161 DPETLANLVVCSLHVGK---SSSRHLSQLKLSHPEHILVKRVSSAEDNFERAVQLVA 214
Cdd:pfam04733 232 DPETLINLVVCALHLGKpaeVSNRNLSQLKLSHPTHPLVKDLNEKEAEFDRAVQQFA 288
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 59-177 9.33e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 9.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383  59 DLYALNVQIFIKMHRAEYAEKQLRVMQQIDEDHTLTQLASAWLNLAVGGSKIQEAYLIFEDFSEKYPMTCLILNGKAVCC 138
Cdd:COG5010   19 KLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLY 98

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 186505383 139 MQMGNFDEAETLLLEALNKDAKDPETLANLVVCSLHVGK 177
Cdd:COG5010   99 SRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQ 137
 
Name Accession Description Interval E-value
Coatomer_E pfam04733
Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, ...
 1-214 3.58e-123

Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex.


Pssm-ID: 398419 [Multi-domain]  Cd Length: 288  Bit Score: 350.24  E-value: 3.58e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383    1 MYLSTPQNKESTISSLKEWLADSTIGNNDTLRLIAGIIFMHEEDYNETLKHTHAGGTMDLYALNVQIFIKMHRAEYAEKQ 80
Cdd:pfam04733  72 EYLNSPSRKESILASLKEWVADSHIGSNSTLRLLAAIIFIHEGDFDDALKHLHKGENLEAMALNVQILLKMHRIDLAEQQ 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383   81 LRVMQQIDEDHTLTQLASAWLNLAVGGSKIQEAYLIFEDFSEKYPMTCLILNGKAVCCMQMGNFDEAETLLLEALNKDAK 160
Cdd:pfam04733 152 LKKMQQIDEDATLTQLANAWVKLAVGGEKIQDAYYIFQEFSEKYDSTPLLLNGQAVCCMCLGRYEEAESLLKEALDKDAK 231

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 186505383  161 DPETLANLVVCSLHVGK---SSSRHLSQLKLSHPEHILVKRVSSAEDNFERAVQLVA 214
Cdd:pfam04733 232 DPETLINLVVCALHLGKpaeVSNRNLSQLKLSHPTHPLVKDLNEKEAEFDRAVQQFA 288
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 59-177 9.33e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 9.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383  59 DLYALNVQIFIKMHRAEYAEKQLRVMQQIDEDHTLTQLASAWLNLAVGGSKIQEAYLIFEDFSEKYPMTCLILNGKAVCC 138
Cdd:COG5010   19 KLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLY 98

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 186505383 139 MQMGNFDEAETLLLEALNKDAKDPETLANLVVCSLHVGK 177
Cdd:COG5010   99 SRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQ 137
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 94-212 1.24e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383  94 TQLASAWLNLAVGGS---KIQEAYLIFEDFSEKYPMTCLILNGKAVCCMQMGNFDEAETLLLEALNKDAKDPETLANLVV 170
Cdd:COG4783    1 AACAEALYALAQALLlagDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 186505383 171 CSLHVGK--SSSRHLSQLKLSHPEHILV-----------KRVSSAEDNFERAVQL 212
Cdd:COG4783   81 ALLKAGDydEALALLEKALKLDPEHPEAylrlarayralGRPDEAIAALEKALEL 135
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 67-177 1.44e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.90  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383  67 IFIKMHRAEYAEKQLRVMQQIDEDHtltqlASAWLNLA---VGGSKIQEAYLIFEDFSEKYPMTCLILNGKAVCCMQMGN 143
Cdd:COG3914  121 LLLALGRLEEALAALRRALALNPDF-----AEAYLNLGealRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGR 195

                         90       100       110
                 ....*....|....*....|....*....|....
gi 186505383 144 FDEAETLLLEALNKDAKDPETLANLVVCSLHVGK 177
Cdd:COG3914  196 LEEAIAAYRRALELDPDNADAHSNLLFALRQACD 229
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
96-177 2.42e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.06  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383  96 LASAWLNLAV---GGSKIQEAYLIFEDFSEKYPMTCLILNGKAVCCMQMGNFDEAETLLLEALNKDAKDPETLANLVVCS 172
Cdd:COG0457    7 DAEAYNNLGLayrRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86


                 ....*
gi 186505383 173 LHVGK 177
Cdd:COG0457   87 QALGR 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 77-169 2.77e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.79  E-value: 2.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383  77 AEKQLRVMQQIDEDHTLTQLASAWLNLAVGgsKIQEAYLIFEDFSEKYPMTCLILNGKAVCCMQMGNFDEAETLLLEALN 156
Cdd:COG2956   27 AIDLLEEALELDPETVEAHLALGNLYRRRG--EYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLE 104

                         90
                 ....*....|...
gi 186505383 157 KDAKDPETLANLV 169
Cdd:COG2956  105 LDPDDAEALRLLA 117
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 41-212 2.80e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 38.05  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383  41 HEEDYNETLKHTHAGGTMDLYALNVQIFIKMHRAEYAEKQLRVMQQIDEDHTLTQLASAWL-NLAVGGSKIQEAYLIFED 119
Cdd:COG3914   24 AELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAaLLLQALGRYEEALALYRR 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383 120 FSEKYPMTCLILNGKAVCCMQMGNFDEAETLLLEALNKDAKDPETLANLVVCSLHVGK-----SSSRHLSQLKLSHPEHI 194
Cdd:COG3914  104 ALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRleeaiAALRRALELDPDNAEAL 183

                        170       180
                 ....*....|....*....|....*.
gi 186505383 195 L--------VKRVSSAEDNFERAVQL 212
Cdd:COG3914  184 NnlgnalqdLGRLEEAIAAYRRALEL 209
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 60-213 3.93e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.40  E-value: 3.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383  60 LYALnVQIFIKMHRAEYAEKQLRVMQQIDED--HTLTQLASAWLNLavggSKIQEAYLIFEDFSEKYPMTCLILNGKAVC 137
Cdd:COG2956  113 LRLL-AEIYEQEGDWEKAIEVLERLLKLGPEnaHAYCELAELYLEQ----GDYDEAIEALEKALKLDPDCARALLLLAEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383 138 CMQMGNFDEAETLLLEALNKDAKDPETLANLVVCSLHVGKSSS-----RHLSQLKLSHPEHILVKRVSSAEDNFERAVQL 212
Cdd:COG2956  188 YLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEalellRKALELDPSDDLLLALADLLERKEGLEAALAL 267


                 .
gi 186505383 213 V 213
Cdd:COG2956  268 L 268
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
95-177 4.79e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 36.91  E-value: 4.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383  95 QLASAWLNLAV---GGSKIQEAYLIFEDFSEKYPMTCLILNGKAVCCMQMGNFDEAETLLLEALNKDAKDPETLANLVVC 171
Cdd:COG0457   74 DDAEALNNLGLalqALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153


                 ....*.
gi 186505383 172 SLHVGK 177
Cdd:COG0457  154 LEKLGR 159
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 60-158 5.93e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 36.09  E-value: 5.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186505383  60 LYALNVQIFIKMHRAEYAEKQLRVMQQIDEDHTLTQLASAWLNLAVGgsKIQEAYLIFEDFSEKYPMTCLILNGKAVCCM 139
Cdd:COG5010   56 IESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSG--DKDEAKEYYEKALALSPDNPNAYSNLAALLL 133

                         90
                 ....*....|....*....
gi 186505383 140 QMGNFDEAETLLLEALNKD 158
Cdd:COG5010  134 SLGQDDEAKAALQRALGTS 152
TPR_19 pfam14559
Tetratricopeptide repeat;
130-163 8.83e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 33.71  E-value: 8.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 186505383  130 ILNGKAVCCMQMGNFDEAETLLLEALNKDAKDPE 163
Cdd:pfam14559  24 ARLGLAEALLALGRLDEAEALLAALPAADPDDPR 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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