tumor protein 63 isoform f [Rattus norvegicus]
Protein Classification
P53 and P53_tetramer domain-containing protein( domain architecture ID 10170140)
P53 and P53_tetramer domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
83-264 | 3.31e-98 | ||||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. : Pssm-ID: 176262 Cd Length: 179 Bit Score: 289.94 E-value: 3.31e-98
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| P53_tetramer | pfam07710 | P53 tetramerization motif; |
297-337 | 6.08e-18 | ||||
P53 tetramerization motif; : Pssm-ID: 462238 Cd Length: 42 Bit Score: 76.55 E-value: 6.08e-18
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| Name | Accession | Description | Interval | E-value | ||||
| P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
83-264 | 3.31e-98 | ||||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. Pssm-ID: 176262 Cd Length: 179 Bit Score: 289.94 E-value: 3.31e-98
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| P53 | pfam00870 | P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ... |
73-264 | 5.43e-92 | ||||
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort. Pssm-ID: 459972 [Multi-domain] Cd Length: 191 Bit Score: 274.55 E-value: 5.43e-92
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| P53_tetramer | pfam07710 | P53 tetramerization motif; |
297-337 | 6.08e-18 | ||||
P53 tetramerization motif; Pssm-ID: 462238 Cd Length: 42 Bit Score: 76.55 E-value: 6.08e-18
|
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| Name | Accession | Description | Interval | E-value | ||||
| P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
83-264 | 3.31e-98 | ||||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. Pssm-ID: 176262 Cd Length: 179 Bit Score: 289.94 E-value: 3.31e-98
|
||||||||
| P53 | pfam00870 | P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ... |
73-264 | 5.43e-92 | ||||
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort. Pssm-ID: 459972 [Multi-domain] Cd Length: 191 Bit Score: 274.55 E-value: 5.43e-92
|
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| P53_tetramer | pfam07710 | P53 tetramerization motif; |
297-337 | 6.08e-18 | ||||
P53 tetramerization motif; Pssm-ID: 462238 Cd Length: 42 Bit Score: 76.55 E-value: 6.08e-18
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| Blast search parameters | ||||
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