serum amyloid A-2 protein isoform b preproprotein [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| SAA super family | cl02506 | Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate ... |
25-77 | 9.52e-33 | ||
Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate amphipathic alpha-helical apolipoproteins that associate predominantly with high density lipoproteins (HDL). They play a role in the mobilization of cholesterol for tissue repair and regeneration. The synthesis of these proteins is greatly increased (as much as a 1000 fold) in inflammation, being a major acute phase reactant together with C-reactive protein. They act as cytokine-like proteins that are involved in cell-cell communication and in inflammatory, immunologic, neoplastic and protective pathways. Prolonged elevation of plasma SAA levels, as in chronic inflammation, results in a pathological condition, called amyloidosis, which is characterized by the highly insoluble accumulation of SAA in several tissues. During chronic inflammation, SAA association with HDL can change its protein and lipid composition which abrogates the HDL anti-atherogenic properties, contributing to a pro-atherogenic state. The actual alignment was detected with superfamily member pfam00277: Pssm-ID: 470594 Cd Length: 102 Bit Score: 108.95 E-value: 9.52e-33
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| Name | Accession | Description | Interval | E-value | ||
| SAA | pfam00277 | Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate ... |
25-77 | 9.52e-33 | ||
Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate amphipathic alpha-helical apolipoproteins that associate predominantly with high density lipoproteins (HDL). They play a role in the mobilization of cholesterol for tissue repair and regeneration. The synthesis of these proteins is greatly increased (as much as a 1000 fold) in inflammation, being a major acute phase reactant together with C-reactive protein. They act as cytokine-like proteins that are involved in cell-cell communication and in inflammatory, immunologic, neoplastic and protective pathways. Prolonged elevation of plasma SAA levels, as in chronic inflammation, results in a pathological condition, called amyloidosis, which is characterized by the highly insoluble accumulation of SAA in several tissues. During chronic inflammation, SAA association with HDL can change its protein and lipid composition which abrogates the HDL anti-atherogenic properties, contributing to a pro-atherogenic state. Pssm-ID: 459744 Cd Length: 102 Bit Score: 108.95 E-value: 9.52e-33
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| SAA | smart00197 | Serum amyloid A proteins; Serum amyloid A proteins are induced during the acute-phase response. ... |
25-77 | 5.08e-30 | ||
Serum amyloid A proteins; Serum amyloid A proteins are induced during the acute-phase response. Secondary amyloidosis is characterised by the extracellular accumulation in tissues of SAA proteins. SAA proteins are apolipoproteins. Pssm-ID: 214552 Cd Length: 103 Bit Score: 101.82 E-value: 5.08e-30
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| Name | Accession | Description | Interval | E-value | ||
| SAA | pfam00277 | Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate ... |
25-77 | 9.52e-33 | ||
Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate amphipathic alpha-helical apolipoproteins that associate predominantly with high density lipoproteins (HDL). They play a role in the mobilization of cholesterol for tissue repair and regeneration. The synthesis of these proteins is greatly increased (as much as a 1000 fold) in inflammation, being a major acute phase reactant together with C-reactive protein. They act as cytokine-like proteins that are involved in cell-cell communication and in inflammatory, immunologic, neoplastic and protective pathways. Prolonged elevation of plasma SAA levels, as in chronic inflammation, results in a pathological condition, called amyloidosis, which is characterized by the highly insoluble accumulation of SAA in several tissues. During chronic inflammation, SAA association with HDL can change its protein and lipid composition which abrogates the HDL anti-atherogenic properties, contributing to a pro-atherogenic state. Pssm-ID: 459744 Cd Length: 102 Bit Score: 108.95 E-value: 9.52e-33
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| SAA | smart00197 | Serum amyloid A proteins; Serum amyloid A proteins are induced during the acute-phase response. ... |
25-77 | 5.08e-30 | ||
Serum amyloid A proteins; Serum amyloid A proteins are induced during the acute-phase response. Secondary amyloidosis is characterised by the extracellular accumulation in tissues of SAA proteins. SAA proteins are apolipoproteins. Pssm-ID: 214552 Cd Length: 103 Bit Score: 101.82 E-value: 5.08e-30
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