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Conserved domains on  [gi|192453580|ref|NP_001122176|]
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pyruvate dehydrogenase kinase, isozyme 4 [Danio rerio]

Protein Classification

PDK/BCKDK family protein kinase( domain architecture ID 13768654)

PDK/BCKDK family protein kinase contains a histidine kinase-like ATPase domain and catalyzes the phosphorylation of protein substrates, such as branched-chain alpha-ketoacid dehydrogenase (BCKD) kinase that catalyzes the phosphorylation and inactivation of the BCKD complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways

CATH:  3.30.565.10|1.20.140.20
EC:  2.7.11.-
Gene Ontology:  GO:0004672|GO:0005524|GO:0006468
PubMed:  10339418|10637609

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 196-362 4.69e-85

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


:

Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 256.50  E-value: 4.69e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 196 DVVEVVRDAYESSKMLCDQYYLTSPEVEIKQVNikgpsdPIHIVYVPSHLYHMLFELFKNAMRATVETHE-TSLHLPPIK 274
Cdd:cd16929    1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDP------SIRFPYVPSHLYYILFELLKNAMRATVESHGdDSDDLPPIK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 275 VRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTAPSPVA-------EDTRNAPLAGFGYGLPISRLYAKYFQGDLQL 347
Cdd:cd16929   75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSLddfsdliSGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                        170
                 ....*....|....*
gi 192453580 348 YSMEGYGTSAVIYLK 362
Cdd:cd16929  155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 30-192 1.45e-64

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


:

Pssm-ID: 463093  Cd Length: 158  Bit Score: 203.50  E-value: 1.45e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580   30 PLSMKQFIDFGSANACEKT--SFMFLRQELPVRLANIMKEIDFLPDKLLGTPSLKLLQSWYAQSLMELVDFLEKDPDDKK 107
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLlkSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580  108 iltKFTETLINVRNRHNNVVPTMAQGVLEYKEAfgvdpVTNQNVQYFLDRFYMSRISTRMLMNQHTLIFDGSTNPAHPKH 187
Cdd:pfam10436  81 ---KFTELLEEILDRHNDVVPTLAQGVLELKKY-----LSPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQSNNPSHPPD 152


                  ....*.
gi 192453580  188 -IGSID 192
Cdd:pfam10436 153 yVGIID 158
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 196-362 4.69e-85

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 256.50  E-value: 4.69e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 196 DVVEVVRDAYESSKMLCDQYYLTSPEVEIKQVNikgpsdPIHIVYVPSHLYHMLFELFKNAMRATVETHE-TSLHLPPIK 274
Cdd:cd16929    1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDP------SIRFPYVPSHLYYILFELLKNAMRATVESHGdDSDDLPPIK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 275 VRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTAPSPVA-------EDTRNAPLAGFGYGLPISRLYAKYFQGDLQL 347
Cdd:cd16929   75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSLddfsdliSGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                        170
                 ....*....|....*
gi 192453580 348 YSMEGYGTSAVIYLK 362
Cdd:cd16929  155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 30-192 1.45e-64

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 203.50  E-value: 1.45e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580   30 PLSMKQFIDFGSANACEKT--SFMFLRQELPVRLANIMKEIDFLPDKLLGTPSLKLLQSWYAQSLMELVDFLEKDPDDKK 107
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLlkSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580  108 iltKFTETLINVRNRHNNVVPTMAQGVLEYKEAfgvdpVTNQNVQYFLDRFYMSRISTRMLMNQHTLIFDGSTNPAHPKH 187
Cdd:pfam10436  81 ---KFTELLEEILDRHNDVVPTLAQGVLELKKY-----LSPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQSNNPSHPPD 152


                  ....*.
gi 192453580  188 -IGSID 192
Cdd:pfam10436 153 yVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 242-362 2.36e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 88.47  E-value: 2.36e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580   242 PSHLYHMLFELFKNAMRATVEThetslhlPPIKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTapspvaeDTRN 321
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG-------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRT-------DKRS 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 192453580   322 APLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLK 362
Cdd:smart00387  69 RKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
195-361 2.14e-16

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 78.02  E-value: 2.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 195 CDVVEVVRDAYESSKMLCDQYYLtspeveikQVNIKGPSDPIHIVYVPSHLYHMLFELFKNAMRATVEThetslhlPPIK 274
Cdd:COG2205   91 VDLAELLEEAVEELRPLAEEKGI--------RLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPG-------GTIT 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 275 VRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYStapspvAEDTRNAPlaGFGYGLPISRLYAKYFQGDLQLYSMEGYG 354
Cdd:COG2205  156 ISARREGDGVRISVSDNGPGIPEEELERIFERFYR------GDNSRGEG--GTGLGLAIVKRIVEAHGGTIWVESEPGGG 227


                 ....*..
gi 192453580 355 TSAVIYL 361
Cdd:COG2205  228 TTFTVTL 234
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 241-362 2.42e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 74.33  E-value: 2.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580  241 VPSHLYHMLFELFKNAMRATVETHEtslhlppIKVRVSLGtEDLTIKMSDRGSGVPLRKIERLFSyMYSTAPSPVAEdtr 320
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGE-------ITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFE-PFSTADKRGGG--- 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 192453580  321 naplaGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLK 362
Cdd:pfam02518  70 -----GTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 235-363 3.87e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 49.17  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 235 PIHIVYVPSHLYHMLFELFKNAMRATVETHetslhlppIKVRVSLGTED-LTIKMSDRGSGVPLRKIERLFSyMYSTAPS 313
Cdd:PRK11091 389 PHKVITDGTRLRQILWNLISNAVKFTQQGG--------VTVRVRYEEGDmLTFEVEDSGIGIPEDELDKIFA-MYYQVKD 459

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 192453580 314 pvAEDTRNAplAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLKA 363
Cdd:PRK11091 460 --SHGGKPA--TGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 196-362 4.69e-85

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 256.50  E-value: 4.69e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 196 DVVEVVRDAYESSKMLCDQYYLTSPEVEIKQVNikgpsdPIHIVYVPSHLYHMLFELFKNAMRATVETHE-TSLHLPPIK 274
Cdd:cd16929    1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDP------SIRFPYVPSHLYYILFELLKNAMRATVESHGdDSDDLPPIK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 275 VRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTAPSPVA-------EDTRNAPLAGFGYGLPISRLYAKYFQGDLQL 347
Cdd:cd16929   75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSLddfsdliSGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                        170
                 ....*....|....*
gi 192453580 348 YSMEGYGTSAVIYLK 362
Cdd:cd16929  155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 30-192 1.45e-64

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 203.50  E-value: 1.45e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580   30 PLSMKQFIDFGSANACEKT--SFMFLRQELPVRLANIMKEIDFLPDKLLGTPSLKLLQSWYAQSLMELVDFLEKDPDDKK 107
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLlkSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580  108 iltKFTETLINVRNRHNNVVPTMAQGVLEYKEAfgvdpVTNQNVQYFLDRFYMSRISTRMLMNQHTLIFDGSTNPAHPKH 187
Cdd:pfam10436  81 ---KFTELLEEILDRHNDVVPTLAQGVLELKKY-----LSPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQSNNPSHPPD 152


                  ....*.
gi 192453580  188 -IGSID 192
Cdd:pfam10436 153 yVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 242-362 2.36e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 88.47  E-value: 2.36e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580   242 PSHLYHMLFELFKNAMRATVEThetslhlPPIKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTapspvaeDTRN 321
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG-------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRT-------DKRS 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 192453580   322 APLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLK 362
Cdd:smart00387  69 RKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
195-361 2.14e-16

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 78.02  E-value: 2.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 195 CDVVEVVRDAYESSKMLCDQYYLtspeveikQVNIKGPSDPIHIVYVPSHLYHMLFELFKNAMRATVEThetslhlPPIK 274
Cdd:COG2205   91 VDLAELLEEAVEELRPLAEEKGI--------RLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPG-------GTIT 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 275 VRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYStapspvAEDTRNAPlaGFGYGLPISRLYAKYFQGDLQLYSMEGYG 354
Cdd:COG2205  156 ISARREGDGVRISVSDNGPGIPEEELERIFERFYR------GDNSRGEG--GTGLGLAIVKRIVEAHGGTIWVESEPGGG 227


                 ....*..
gi 192453580 355 TSAVIYL 361
Cdd:COG2205  228 TTFTVTL 234
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 241-362 2.42e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 74.33  E-value: 2.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580  241 VPSHLYHMLFELFKNAMRATVETHEtslhlppIKVRVSLGtEDLTIKMSDRGSGVPLRKIERLFSyMYSTAPSPVAEdtr 320
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGE-------ITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFE-PFSTADKRGGG--- 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 192453580  321 naplaGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLK 362
Cdd:pfam02518  70 -----GTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
196-361 7.90e-14

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 71.86  E-value: 7.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 196 DVVEVVRDAYESSKMLCDQYYLTspeveikqVNIKGPSDPIHIVYVPSHLYHMLFELFKNAMRATVETHetslhlpPIKV 275
Cdd:COG0642  183 DLAELLEEVVELFRPLAEEKGIE--------LELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGG-------TVTV 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 276 RVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTAPSPVAEdtrnaplaGFGYGLPISRLYAKYFQGDLQLYSMEGYGT 355
Cdd:COG0642  248 SVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG--------GTGLGLAIVKRIVELHGGTIEVESEPGKGT 319


                 ....*.
gi 192453580 356 SAVIYL 361
Cdd:COG0642  320 TFTVTL 325
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 195-361 3.05e-09

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 58.43  E-value: 3.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 195 CDVVEVVRDA---YESSkmlcdqyyLTSPEVEIKqvnIKGPSDPIHIVYVPSHLYHMLFELFKNAMRATVEThetslhlP 271
Cdd:COG5000  276 VDLNELLREVlalYEPA--------LKEKDIRLE---LDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEG-------G 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 272 PIKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTAPSpvaedtrnaplaGFGYGLPISRLYAKYFQGDLQLYSME 351
Cdd:COG5000  338 EIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPK------------GTGLGLAIVKKIVEEHGGTIELESRP 405

                        170
                 ....*....|
gi 192453580 352 GYGTSAVIYL 361
Cdd:COG5000  406 GGGTTFTIRL 415
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
195-363 4.56e-09

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 57.64  E-value: 4.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 195 CDVVEVVRDAYESSKMLCDQyyltspeveiKQVNIK--GPSDPIHIVYVPSHLYHMLFELFKNAMRATVETHEtslhlpp 272
Cdd:COG5002  240 VDLAELLEEVVEELRPLAEE----------KGIELEldLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGT------- 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 273 IKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYStapspvAEDTRNAPLAGFGYGLPISRLYAKYFQGDLQLYSMEG 352
Cdd:COG5002  303 ITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYR------VDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPG 376

                        170
                 ....*....|.
gi 192453580 353 YGTSAVIYLKA 363
Cdd:COG5002  377 KGTTFTITLPL 387
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-361 1.66e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 49.34  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 242 PSHLYHMLFELFKNAMRATVETHEtslhlppIKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTapSPVAEDTrn 321
Cdd:cd16943    1 PSQLNQVLLNLLVNAAQAMEGRGR-------ITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTT--KPVGEGT-- 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 192453580 322 aplagfGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYL 361
Cdd:cd16943   70 ------GLGLSLSYRIIQKHGGTIRVASVPGGGTRFTIIL 103
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 195-361 5.52e-07

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 51.34  E-value: 5.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 195 CDVVEVVRDAYEsskmlcdqyyLTSPEVEIKQVNI-KGPSDPIHIVYV-PSHLYHMLFELFKNAMRATVETHEtslhlPP 272
Cdd:COG4191  215 VDLNELIDEALE----------LLRPRLKARGIEVeLDLPPDLPPVLGdPGQLEQVLLNLLINAIDAMEEGEG-----GR 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 273 IKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTapSPVAEdtrnaplaGFGYGLPISRLYAKYFQGDLQLYSMEG 352
Cdd:COG4191  280 ITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTT--KPVGK--------GTGLGLSISYGIVEKHGGRIEVESEPG 349


                 ....*....
gi 192453580 353 YGTSAVIYL 361
Cdd:COG4191  350 GGTTFTITL 358
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 252-361 6.81e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 47.28  E-value: 6.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 252 LFKNAMRATVETHEtslhlPPIKVRVSLGTE--DLTIKMSDRGSGVPLRKIERLFSYMYSTAPSpvaedtrnaplAGFGY 329
Cdd:cd16915    8 LIDNALDALAATGA-----PNKQVEVFLRDEgdDLVIEVRDTGPGIAPELRDKVFERGVSTKGQ-----------GERGI 71

                         90       100       110
                 ....*....|....*....|....*....|..
gi 192453580 330 GLPISRLYAKYFQGDLQLYSMEGYGTSAVIYL 361
Cdd:cd16915   72 GLALVRQSVERLGGSITVESEPGGGTTFSIRI 103
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 235-363 3.87e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 49.17  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 235 PIHIVYVPSHLYHMLFELFKNAMRATVETHetslhlppIKVRVSLGTED-LTIKMSDRGSGVPLRKIERLFSyMYSTAPS 313
Cdd:PRK11091 389 PHKVITDGTRLRQILWNLISNAVKFTQQGG--------VTVRVRYEEGDmLTFEVEDSGIGIPEDELDKIFA-MYYQVKD 459

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 192453580 314 pvAEDTRNAplAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLKA 363
Cdd:PRK11091 460 --SHGGKPA--TGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 252-361 5.29e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 48.31  E-value: 5.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 252 LFKNAMRATVETHETSlhlPPIKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTAPSpvaedtrnaplAGFGYGL 331
Cdd:COG3290  289 LLDNAIEAVEKLPEEE---RRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLG-----------EGRGLGL 354

                         90       100       110
                 ....*....|....*....|....*....|
gi 192453580 332 PISRLYAKYFQGDLQLYSMEGYGTSAVIYL 361
Cdd:COG3290  355 ALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
249-368 7.11e-06

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 48.04  E-value: 7.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 249 LFELFKNAMRATVETHEtslhlppIKVRVSLGTED-LTIKMSDRGSGVPLRKIERLFSYMYSTAPSpvaedtrnaplaGF 327
Cdd:PRK11360 505 LLNILINAVQAISARGK-------IRIRTWQYSDGqVAVSIEDNGCGIDPELLKKIFDPFFTTKAK------------GT 565

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 192453580 328 GYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLKALSTES 368
Cdd:PRK11360 566 GLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 273-357 1.85e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 43.22  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 273 IKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTA-PSPVAEDTrnaplagfGYGLPISRLYAKYFQGDLQLYSM- 350
Cdd:cd16945   26 IALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPrPHSGQKST--------GLGLAFVQEVAQLHGGRITLRNRp 97


                 ....*..
gi 192453580 351 EGYGTSA 357
Cdd:cd16945   98 DGVLAFL 104
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 284-361 3.79e-05

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 42.75  E-value: 3.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 284 LTIKMSDRGSGVPLRKIERLFSYMYSTAPspvaedtrnaplAGFGYGLPISRLY--AKYFQGDLQLYSMEGYGTSAVIYL 361
Cdd:cd16919   48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKE------------VGKGTGLGLSMVYgfVKQSGGHLRIYSEPGVGTTVRIYL 115
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-355 3.87e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 42.38  E-value: 3.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 249 LFELFKNAMRATVETHETSLHLppiKVRVSLGTED-LTIKMSDRGSGVPLRKIERLFSYMYSTAPSpvaedtrnaplaGF 327
Cdd:cd16920    5 LINLVRNGIEAMSEGGCERREL---TIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------------GL 69

                         90       100
                 ....*....|....*....|....*...
gi 192453580 328 GYGLPISRLYAKYFQGDLQLYSMEGYGT 355
Cdd:cd16920   70 GMGLSICRSIIEAHGGRLSVESPAGGGA 97
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 273-355 6.78e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 41.71  E-value: 6.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 273 IKVRVSLGTED-----LTIKMSDRGSGVPLRKIERLFSyMYSTAPSPVaedTRNAplAGFGYGLPISRLYAKYFQGDLQL 347
Cdd:cd16922   21 VTLRVSLEEEEedgvqLRFSVEDTGIGIPEEQQARLFE-PFSQADSST---TRKY--GGTGLGLAISKKLVELMGGDISV 94


                 ....*...
gi 192453580 348 YSMEGYGT 355
Cdd:cd16922   95 ESEPGQGS 102
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 226-362 7.94e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 42.12  E-value: 7.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 226 QVNIKGPSDPIHIVYVPSHLYHMLFELFKNAMRATVETHETSLHLppikvrvSLGTEDLTIKMSDRGSGVPLRKIERLFS 305
Cdd:cd16947    2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTL-------REDEKHVYIDIWDKGKGISETEKDHVFE 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 192453580 306 YMYStapspvAEDTRNAPLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLK 362
Cdd:cd16947   75 RLYT------LEDSRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTLK 125
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 271-335 1.57e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 41.02  E-value: 1.57e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 192453580 271 PPIKVRVSL----GTEDLTIKMSDRGSGVPLRKIERLFSYMYSTAPSPVAEDTRNaplagfGYGLPISR 335
Cdd:cd16953   17 PPDTGRITVsampTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHS------GLGLSISR 79
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 225-349 2.18e-04

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 43.52  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 225 KQVNIKGPSDPIhIVYVPSHLYHMLFELFKNAMRAtVETHetslhlPPIKVRVSLGTEDLTIKMSDRGSGVPLrkIERLF 304
Cdd:COG4192  525 QQITLHIPDDLM-VQGDQVLLEQVLVNLLVNALDA-VATQ------PQISVDLLSNAENLRVAISDNGNGWPL--VDKLF 594

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 192453580 305 SYMYSTAPspvaedtrnaplAGFGYGLPISRLYAKYFQGDLQLYS 349
Cdd:COG4192  595 TPFTTTKE------------VGLGLGLSICRSIMQQFGGDLYLAS 627
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-345 3.07e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 40.14  E-value: 3.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 242 PSHLYHMLFELFKNAMRATVETHetslhlppiKVRVSLGTED--LTIKMSDRGSGVPLRKIERLFSYMYSTapspvaEDT 319
Cdd:cd16946    2 RDRLQQLFVNLLENSLRYTDTGG---------KLRIRAAQTPqeVRLDVEDSAPGVSDDQLARLFERFYRV------ESS 66

                         90       100
                 ....*....|....*....|....*.
gi 192453580 320 RNAPLAGFGYGLPISRLYAKYFQGDL 345
Cdd:cd16946   67 RNRASGGSGLGLAICHNIALAHGGTI 92
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 273-365 7.26e-04

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 41.75  E-value: 7.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 273 IKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTaPSPvaEDTRNaplaGFGYGLPISRLYAKYFQGDLQLYSMEG 352
Cdd:PRK11100 390 ITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSL-PRP--ANGRK----STGLGLAFVREVARLHGGEVTLRNRPE 462

                         90
                 ....*....|...
gi 192453580 353 YGTSAVIYLKALS 365
Cdd:PRK11100 463 GGVLATLTLPRHF 475
PRK15347 PRK15347
two component system sensor kinase;
273-356 2.95e-03

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 40.01  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 273 IKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTapspvaeDTRNAplaGFGYGLPISRLYAKYFQGDLQLYSMEG 352
Cdd:PRK15347 534 IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQA-------DTHSQ---GTGLGLTIASSLAKMMGGELTLFSTPG 603


                 ....
gi 192453580 353 YGTS 356
Cdd:PRK15347 604 VGSC 607
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
242-368 3.96e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 39.06  E-value: 3.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 242 PSHLYHMLFELFKNAMRA-------TVEThETSLHLPPIKVRVSLGtedLTIKMSDRGSGVPLRKIERLFSYMYSTAPSp 314
Cdd:COG3852  242 PDQLIQVLLNLVRNAAEAmpeggtiTIRT-RVERQVTLGGLRPRLY---VRIEVIDNGPGIPEEILDRIFEPFFTTKEK- 316

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 192453580 315 vaedtrnaplaGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLKALSTES 368
Cdd:COG3852  317 -----------GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 221-361 4.13e-03

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 39.19  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192453580 221 EVEIKQVnikgpsdpihivyvpshlyhmLFELFKNAMRATVEthetslhlpPIKVRVSLGTED---LTIKMSDRGSGVPL 297
Cdd:COG5809  377 ENQLKQV---------------------FINLLKNAIEAMPE---------GGNITIETKAEDddkVVISVTDEGCGIPE 426

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 192453580 298 RKIERLFSYMYSTAPSpvaedtrnaplaGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYL 361
Cdd:COG5809  427 ERLKKLGEPFYTTKEK------------GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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