NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|193202769|ref|NP_001122474|]
View 

TATA box-binding protein-like 1 [Caenorhabditis elegans]

Protein Classification

TBP family protein( domain architecture ID 10139978)

TBP family protein similar to TATA-box-binding protein (TBP), a general transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID

Gene Ontology:  GO:0006352|GO:0003677

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
 266-442 4.03e-90

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


:

Pssm-ID: 239953  Cd Length: 174  Bit Score: 273.06  E-value: 4.03e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 266 IDIQIRNVVCNYTLPLHIDLRKLAMNTHNVTYERE-KGVMMKQKRsPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARH 344
Cdd:cd04517    1 LDILIVNVVCQFSLRCHIDLRKLALAGRNVEYNPRyPKVTMRLRE-PRATASVWSSGKITITGATSEEEAKQAARRAARL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 345 VQRVMGKTkerVSIRNYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQ 424
Cdd:cd04517   80 LQKLGFKV---VRFSNFRVVNVLATCSMPFPIRLDELAAKNRSSASYEPELHPGVVYRITGPRATLSIFSTGSVTVTGAR 156

                        170
                 ....*....|....*...
gi 193202769 425 SEADVLEVLSKIYPIVLE 442
Cdd:cd04517  157 SMEDVREAVEKIYPIVFE 174
KLF1_2_4_N super family cl41729
N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel ...
 183-217 1.62e-04

N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF1, KLF2, KLF4, and similar proteins.


The actual alignment was detected with superfamily member cd22056:

Pssm-ID: 425360 [Multi-domain]  Cd Length: 339  Bit Score: 43.88  E-value: 1.62e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 193202769 183 HRQPQMHHNQQHQMVQPQMTRHQMAQHHAQQPHPQ 217
Cdd:cd22056  244 HLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQ 278
 
Name Accession Description Interval E-value
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
 266-442 4.03e-90

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


Pssm-ID: 239953  Cd Length: 174  Bit Score: 273.06  E-value: 4.03e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 266 IDIQIRNVVCNYTLPLHIDLRKLAMNTHNVTYERE-KGVMMKQKRsPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARH 344
Cdd:cd04517    1 LDILIVNVVCQFSLRCHIDLRKLALAGRNVEYNPRyPKVTMRLRE-PRATASVWSSGKITITGATSEEEAKQAARRAARL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 345 VQRVMGKTkerVSIRNYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQ 424
Cdd:cd04517   80 LQKLGFKV---VRFSNFRVVNVLATCSMPFPIRLDELAAKNRSSASYEPELHPGVVYRITGPRATLSIFSTGSVTVTGAR 156

                        170
                 ....*....|....*...
gi 193202769 425 SEADVLEVLSKIYPIVLE 442
Cdd:cd04517  157 SMEDVREAVEKIYPIVFE 174
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 268-444 5.24e-35

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 129.05  E-value: 5.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 268 IQIRNVVCNYTLPLHIDLRKLAMNTHNVTY--EREKGVMMKQkRSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARHV 345
Cdd:PLN00062   2 PTLQNIVSTVNLDCKLDLKKIALQARNAEYnpKRFAAVIMRI-REPKTTALIFASGKMVCTGAKSEHDSKLAARKYARII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 346 QRVMGKTKervsIRNYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQS 425
Cdd:PLN00062  81 QKLGFPAK----FKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKV 156

                        170
                 ....*....|....*....
gi 193202769 426 EADVLEVLSKIYPIVLEFR 444
Cdd:PLN00062 157 REEIYTAFENIYPVLTEFR 175
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
360-443 1.32e-25

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 99.82  E-value: 1.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769  360 NYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQSEADVLEVLSKIYPI 439
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80


                  ....
gi 193202769  440 VLEF 443
Cdd:pfam00352  81 LQKL 84
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
268-437 8.64e-20

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 86.79  E-value: 8.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 268 IQIRNVVCNYTLPLHIDLRKLAMNTHNVTYEREK--GVMMKQKrSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARHV 345
Cdd:COG2101    4 IEIENIVASGSLGQELDLEKLAEDLPNAEYNPEQfpGLVYRLK-EPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 346 QRVMGKTKERVSIRnyrVNNVLATCRLPFGIKIEEVAAKYPSEST-YEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQ 424
Cdd:COG2101   83 RKLGIEIPDEPEIT---VQNIVASADLGREINLNALAIGLGLENIeYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAK 159

                        170
                 ....*....|...
gi 193202769 425 SEADVLEVLSKIY 437
Cdd:COG2101  160 DEEEAERAVDKLR 172
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 183-217 1.62e-04

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 43.88  E-value: 1.62e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 193202769 183 HRQPQMHHNQQHQMVQPQMTRHQMAQHHAQQPHPQ 217
Cdd:cd22056  244 HLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQ 278
 
Name Accession Description Interval E-value
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
 266-442 4.03e-90

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


Pssm-ID: 239953  Cd Length: 174  Bit Score: 273.06  E-value: 4.03e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 266 IDIQIRNVVCNYTLPLHIDLRKLAMNTHNVTYERE-KGVMMKQKRsPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARH 344
Cdd:cd04517    1 LDILIVNVVCQFSLRCHIDLRKLALAGRNVEYNPRyPKVTMRLRE-PRATASVWSSGKITITGATSEEEAKQAARRAARL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 345 VQRVMGKTkerVSIRNYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQ 424
Cdd:cd04517   80 LQKLGFKV---VRFSNFRVVNVLATCSMPFPIRLDELAAKNRSSASYEPELHPGVVYRITGPRATLSIFSTGSVTVTGAR 156

                        170
                 ....*....|....*...
gi 193202769 425 SEADVLEVLSKIYPIVLE 442
Cdd:cd04517  157 SMEDVREAVEKIYPIVFE 174
TBP_TLF cd00652
TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription ...
 267-442 4.42e-73

TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA. New members of the TBP family, called TBP-like proteins (TBLP, TLF, TLP) or TBP-related factors (TRF1, TRF2,TRP), are similar to the core domain of TBPs, with identical or chemically similar amino acids at many equivalent positions, suggesting similar structure. However, TLFs contain distinct, conserved amino acids at several positions that distinguish them from TBP.


Pssm-ID: 238352 [Multi-domain]  Cd Length: 174  Bit Score: 228.97  E-value: 4.42e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 267 DIQIRNVVCNYTLPLHIDLRKLAMNTHNVTYEREK--GVMMKQkRSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARH 344
Cdd:cd00652    1 SPKIQNIVATVNLGCELDLRKIALAARNAEYNPKRfpGVIMRL-REPKTTALIFSSGKMVITGAKSEEDAKLAARKYARI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 345 VQRVMGKTKErvsIRNYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQ 424
Cdd:cd00652   80 LQKLGFPVEK---FPEFKVQNIVASCDLGFPIRLEELALKHPENASYEPELFPGLIYRMDEPKVVLLIFVSGKIVITGAK 156

                        170
                 ....*....|....*...
gi 193202769 425 SEADVLEVLSKIYPIVLE 442
Cdd:cd00652  157 SREDIYEAVEKIYPILKE 174
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 269-443 3.94e-37

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 134.65  E-value: 3.94e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 269 QIRNVVCNYTLPLHIDLRKLAMNTHNVTYEREK--GVMMKQkRSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARHVQ 346
Cdd:cd04516    3 KIQNIVATVNLGCKLDLKKIALRARNAEYNPKRfaAVIMRI-REPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARIIQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 347 RVMGKTKervsIRNYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQSE 426
Cdd:cd04516   82 KLGFPAK----FTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSR 157

                        170
                 ....*....|....*..
gi 193202769 427 ADVLEVLSKIYPIVLEF 443
Cdd:cd04516  158 EEIYQAFENIYPILLQF 174
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 268-444 5.24e-35

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 129.05  E-value: 5.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 268 IQIRNVVCNYTLPLHIDLRKLAMNTHNVTY--EREKGVMMKQkRSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARHV 345
Cdd:PLN00062   2 PTLQNIVSTVNLDCKLDLKKIALQARNAEYnpKRFAAVIMRI-REPKTTALIFASGKMVCTGAKSEHDSKLAARKYARII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 346 QRVMGKTKervsIRNYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQS 425
Cdd:PLN00062  81 QKLGFPAK----FKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKV 156

                        170
                 ....*....|....*....
gi 193202769 426 EADVLEVLSKIYPIVLEFR 444
Cdd:PLN00062 157 REEIYTAFENIYPVLTEFR 175
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
360-443 1.32e-25

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 99.82  E-value: 1.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769  360 NYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQSEADVLEVLSKIYPI 439
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80


                  ....
gi 193202769  440 VLEF 443
Cdd:pfam00352  81 LQKL 84
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
267-347 8.64e-24

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 94.81  E-value: 8.64e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769  267 DIQIRNVVCNYTLPLHIDLRKLAMN-THNVTYEREK--GVMMKQkRSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIAR 343
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKlLENVEYEPERfpGLVYRL-REPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAP 79


                  ....
gi 193202769  344 HVQR 347
Cdd:pfam00352  80 ILQK 83
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 267-437 3.12e-20

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 88.07  E-value: 3.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 267 DIQIRNVVCNYTLPLHIDLRKLAMNTHNVTYEREKGvmmkqkrsPGCYIK---------VYSSGKVYIVGCRSEADCKRA 337
Cdd:cd04518    1 SLKIENIVASVDLGQELDLEKVAAELPNAEYNPDQF--------PGLVYRledpkiaalIFRSGKMVCTGAKSVEDLHRA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 338 ARSIARHVQRVMGKTKERVSIRnyrVNNVLATCRLPFGIKIEEVAAKYPSeSTYEPELSVGLVWRSVTPKATLRIHTTGS 417
Cdd:cd04518   73 VKEIIKKLKDYGIKVIEKPEIK---VQNIVASADLGREVNLDAIAIGLPN-AEYEPEQFPGLVYRLDEPKVVLLLFSSGK 148

                        170       180
                 ....*....|....*....|
gi 193202769 418 ITVTGAQSEADVLEVLSKIY 437
Cdd:cd04518  149 MVITGAKSEEDAKRAVEKLL 168
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
268-437 8.64e-20

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 86.79  E-value: 8.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 268 IQIRNVVCNYTLPLHIDLRKLAMNTHNVTYEREK--GVMMKQKrSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARHV 345
Cdd:COG2101    4 IEIENIVASGSLGQELDLEKLAEDLPNAEYNPEQfpGLVYRLK-EPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 346 QRVMGKTKERVSIRnyrVNNVLATCRLPFGIKIEEVAAKYPSEST-YEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQ 424
Cdd:COG2101   83 RKLGIEIPDEPEIT---VQNIVASADLGREINLNALAIGLGLENIeYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAK 159

                        170
                 ....*....|...
gi 193202769 425 SEADVLEVLSKIY 437
Cdd:COG2101  160 DEEEAERAVDKLR 172
PRK00394 PRK00394
transcription factor; Reviewed
 268-447 1.58e-16

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 77.58  E-value: 1.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 268 IQIRNVVCNYTLPLHIDLRKLAMNTHNVTYEREK--GVMMKQKrSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARHV 345
Cdd:PRK00394   1 IKIENIVASTDLGQELDLEKVAEDLPNAEYNPEQfpGLVYRLE-DPKIAALIFRSGKVVCTGAKSVEDLHEAVKIIIKKL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 346 QRVMGKTKERVSIRnyrVNNVLATCRLPFGIKIEEVAAKYPSEST-YEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQ 424
Cdd:PRK00394  80 KELGIKVIDEPEIK---VQNIVASADLGVELNLNAIAIGLGLENIeYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAK 156

                        170       180
                 ....*....|....*....|...
gi 193202769 425 SEADVLEVLSKIYPIVLEFRCLE 447
Cdd:PRK00394 157 SEEDAEKAVEKILEKLEELGLLE 179
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 263-346 1.32e-09

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 57.26  E-value: 1.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 263 DGDIDIQIRNVVCNYTLPLHIDLRKLAMNTHNVTYEREK--GVMMKQKrSPGCYIKVYSSGKVYIVGCRSEADCKRAARS 340
Cdd:cd04518   88 IEKPEIKVQNIVASADLGREVNLDAIAIGLPNAEYEPEQfpGLVYRLD-EPKVVLLLFSSGKMVITGAKSEEDAKRAVEK 166


                 ....*.
gi 193202769 341 IARHVQ 346
Cdd:cd04518  167 LLSRLK 172
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
263-342 2.32e-08

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 53.67  E-value: 2.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 263 DGDIDIQIRNVVCNYTLPLHIDLRKLA--MNTHNVTYEREK--GVMMKQKrSPGCYIKVYSSGKVYIVGCRSEADCKRAA 338
Cdd:COG2101   90 PDEPEITVQNIVASADLGREINLNALAigLGLENIEYEPEQfpGLVYRLD-DPKVVLLLFSSGKLVITGAKDEEEAERAV 168


                 ....
gi 193202769 339 RSIA 342
Cdd:COG2101  169 DKLR 172
PRK00394 PRK00394
transcription factor; Reviewed
 260-346 9.60e-08

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 52.16  E-value: 9.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193202769 260 MPDDGDIDIQIRNVVCNYTLPLHIDLRKLAM--NTHNVTYEREK--GVMMKQKrSPGCYIKVYSSGKVYIVGCRSEADCK 335
Cdd:PRK00394  84 IKVIDEPEIKVQNIVASADLGVELNLNAIAIglGLENIEYEPEQfpGLVYRLD-DPKVVVLLFGSGKLVITGAKSEEDAE 162

                         90
                 ....*....|.
gi 193202769 336 RAARSIARHVQ 346
Cdd:PRK00394 163 KAVEKILEKLE 173
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 183-217 1.62e-04

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 43.88  E-value: 1.62e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 193202769 183 HRQPQMHHNQQHQMVQPQMTRHQMAQHHAQQPHPQ 217
Cdd:cd22056  244 HLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQ 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH