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Conserved domains on  [gi|193210134|ref|NP_001122709|]
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Glycerol-3-phosphate dehydrogenase [NAD(+)] [Caenorhabditis elegans]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-297 6.67e-138

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 393.25  E-value: 6.67e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134    5 KVTIIGSGNWGSAIARIVGSTTKSFPDEFDPTVRMWVFEEIVNGEKLSEVINNRHENIKYLPGKVLPNNV---------- 74
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLvavpdlveaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   75 -------------------------------GVSTEK-----RGGLKLISEEIKEILKIEVSVLMGANLAPEVANDNFCE 118
Cdd:TIGR03376  81 kgadilvfviphqflegickqlkghvkpnarAISCIKglevsKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  119 ATIGCKRKAE---DGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFV 195
Cdd:TIGR03376 161 TTVGYRDPADfdvDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  196 EHYYPGSNLQTFFESCGIADLITTCYGGRNRKVCEAFVKTGKSMAEVEKELLNGQSAQGPLTAEEVYLMMHKTGLDAKFP 275
Cdd:TIGR03376 241 RMFFPTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEFP 320

                         330       340
                  ....*....|....*....|..
gi 193210134  276 LFTAVHKICAGEMKPAELVDCL 297
Cdd:TIGR03376 321 LFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-297 6.67e-138

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 393.25  E-value: 6.67e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134    5 KVTIIGSGNWGSAIARIVGSTTKSFPDEFDPTVRMWVFEEIVNGEKLSEVINNRHENIKYLPGKVLPNNV---------- 74
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLvavpdlveaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   75 -------------------------------GVSTEK-----RGGLKLISEEIKEILKIEVSVLMGANLAPEVANDNFCE 118
Cdd:TIGR03376  81 kgadilvfviphqflegickqlkghvkpnarAISCIKglevsKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  119 ATIGCKRKAE---DGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFV 195
Cdd:TIGR03376 161 TTVGYRDPADfdvDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  196 EHYYPGSNLQTFFESCGIADLITTCYGGRNRKVCEAFVKTGKSMAEVEKELLNGQSAQGPLTAEEVYLMMHKTGLDAKFP 275
Cdd:TIGR03376 241 RMFFPTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEFP 320

                         330       340
                  ....*....|....*....|..
gi 193210134  276 LFTAVHKICAGEMKPAELVDCL 297
Cdd:TIGR03376 321 LFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-299 1.08e-119

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 348.16  E-value: 1.08e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   1 MSPKKVTIIGSGNWGSAIARIVGSTTKSFPdEFDPTVRMWVFEEIVNGEKLSEVINNRHENIKYLPGKVLPNNV------ 74
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNY-IFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIvavsdl 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  75 -------------------------------------GVSTEK-----RGGLKLISEEIKEILKIEVSVLMGANLAPEVA 112
Cdd:PTZ00345  88 keavedadllifviphqflesvlsqikennnlkkharAISLTKgiiveNGKPVLCSDVIEEELGIPCCALSGANVANDVA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 113 NDNFCEATIGCKRKaEDGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETT 192
Cdd:PTZ00345 168 REEFSEATIGCEDK-DDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMK 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 193 KFVEHYYPGSNLQTFFESCGIADLITTCYGGRNRKVCEAFVKTG--KSMAEVEKELLNGQSAQGPLTAEEVYLMMHKTGL 270
Cdd:PTZ00345 247 LFGKIFFPNVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDL 326

                        330       340
                 ....*....|....*....|....*....
gi 193210134 271 DAKFPLFTAVHKICAGEMKPAELVDCLRN 299
Cdd:PTZ00345 327 KKEFPLFTVTYKIAFEGADPSSLIDVLST 355
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-297 1.39e-63

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 203.34  E-value: 1.39e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   4 KKVTIIGSGNWGSAIARIVGSTTKSfpdefdptVRMWVF-EEIVngeklsEVINNRHENIKYLPGKVLPNNVGVSTE--- 79
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHE--------VTLWGRdPEVA------EEINETRENPRYLPGVKLPENLRATSDlee 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  80 --------------------------------------K---RGGLKLISEEIKEIL--KIEVSVLMGANLAPEVANDNF 116
Cdd:COG0240   67 alagadlvllavpsqalrevleqlapllppgapvvsatKgiePGTGLLMSEVIAEELpgALRIAVLSGPSFAEEVARGLP 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 117 CEATIGCkRKAEDGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVE 196
Cdd:COG0240  147 TAVVVAS-EDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGV 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 197 HYypGSNLQTFFESCGIADLITTCYG--GRNRKVCEAFVKtGKSMAEVEKELlnGQSAQGPLTAEEVYLMMHKTGLDAkf 274
Cdd:COG0240  226 AL--GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLGVEM-- 298

                        330       340
                 ....*....|....*....|...
gi 193210134 275 PLFTAVHKICAGEMKPAELVDCL 297
Cdd:COG0240  299 PITEAVYAVLYEGKSPREAVEAL 321
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 149-295 1.64e-62

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 194.14  E-value: 1.64e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  149 DAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVEHYypGSNLQTFFESCGIADLITTCYGG--RNR 226
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKAL--GAKPETFFGLAGLGDLIVTCTSGlsRNR 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193210134  227 KVCEAFVKtGKSMAEVEKELlnGQSAQGPLTAEEVYLMMHKTGLDakFPLFTAVHKICAGEMKPAELVD 295
Cdd:pfam07479  79 RFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGVE--MPIFEAVYRILYEGKSPEEALE 142
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-297 6.67e-138

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 393.25  E-value: 6.67e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134    5 KVTIIGSGNWGSAIARIVGSTTKSFPDEFDPTVRMWVFEEIVNGEKLSEVINNRHENIKYLPGKVLPNNV---------- 74
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLvavpdlveaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   75 -------------------------------GVSTEK-----RGGLKLISEEIKEILKIEVSVLMGANLAPEVANDNFCE 118
Cdd:TIGR03376  81 kgadilvfviphqflegickqlkghvkpnarAISCIKglevsKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  119 ATIGCKRKAE---DGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFV 195
Cdd:TIGR03376 161 TTVGYRDPADfdvDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  196 EHYYPGSNLQTFFESCGIADLITTCYGGRNRKVCEAFVKTGKSMAEVEKELLNGQSAQGPLTAEEVYLMMHKTGLDAKFP 275
Cdd:TIGR03376 241 RMFFPTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEFP 320

                         330       340
                  ....*....|....*....|..
gi 193210134  276 LFTAVHKICAGEMKPAELVDCL 297
Cdd:TIGR03376 321 LFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-299 1.08e-119

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 348.16  E-value: 1.08e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   1 MSPKKVTIIGSGNWGSAIARIVGSTTKSFPdEFDPTVRMWVFEEIVNGEKLSEVINNRHENIKYLPGKVLPNNV------ 74
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNY-IFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIvavsdl 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  75 -------------------------------------GVSTEK-----RGGLKLISEEIKEILKIEVSVLMGANLAPEVA 112
Cdd:PTZ00345  88 keavedadllifviphqflesvlsqikennnlkkharAISLTKgiiveNGKPVLCSDVIEEELGIPCCALSGANVANDVA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 113 NDNFCEATIGCKRKaEDGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETT 192
Cdd:PTZ00345 168 REEFSEATIGCEDK-DDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMK 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 193 KFVEHYYPGSNLQTFFESCGIADLITTCYGGRNRKVCEAFVKTG--KSMAEVEKELLNGQSAQGPLTAEEVYLMMHKTGL 270
Cdd:PTZ00345 247 LFGKIFFPNVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDL 326

                        330       340
                 ....*....|....*....|....*....
gi 193210134 271 DAKFPLFTAVHKICAGEMKPAELVDCLRN 299
Cdd:PTZ00345 327 KKEFPLFTVTYKIAFEGADPSSLIDVLST 355
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-297 1.39e-63

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 203.34  E-value: 1.39e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   4 KKVTIIGSGNWGSAIARIVGSTTKSfpdefdptVRMWVF-EEIVngeklsEVINNRHENIKYLPGKVLPNNVGVSTE--- 79
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHE--------VTLWGRdPEVA------EEINETRENPRYLPGVKLPENLRATSDlee 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  80 --------------------------------------K---RGGLKLISEEIKEIL--KIEVSVLMGANLAPEVANDNF 116
Cdd:COG0240   67 alagadlvllavpsqalrevleqlapllppgapvvsatKgiePGTGLLMSEVIAEELpgALRIAVLSGPSFAEEVARGLP 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 117 CEATIGCkRKAEDGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVE 196
Cdd:COG0240  147 TAVVVAS-EDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGV 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 197 HYypGSNLQTFFESCGIADLITTCYG--GRNRKVCEAFVKtGKSMAEVEKELlnGQSAQGPLTAEEVYLMMHKTGLDAkf 274
Cdd:COG0240  226 AL--GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLGVEM-- 298

                        330       340
                 ....*....|....*....|...
gi 193210134 275 PLFTAVHKICAGEMKPAELVDCL 297
Cdd:COG0240  299 PITEAVYAVLYEGKSPREAVEAL 321
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 149-295 1.64e-62

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 194.14  E-value: 1.64e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  149 DAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVEHYypGSNLQTFFESCGIADLITTCYGG--RNR 226
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKAL--GAKPETFFGLAGLGDLIVTCTSGlsRNR 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193210134  227 KVCEAFVKtGKSMAEVEKELlnGQSAQGPLTAEEVYLMMHKTGLDakFPLFTAVHKICAGEMKPAELVD 295
Cdd:pfam07479  79 RFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGVE--MPIFEAVYRILYEGKSPEEALE 142
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
4-297 2.23e-55

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 182.19  E-value: 2.23e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   4 KKVTIIGSGNWGSAIArivgsttKSFPDEFDPtVRMWVFEEIVNgeklsEVINNRHENIKYLPGKVLPNNVGVSTE---- 79
Cdd:PRK00094   2 MKIAVLGAGSWGTALA-------IVLARNGHD-VTLWARDPEQA-----AEINADRENPRYLPGIKLPDNLRATTDlaea 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  80 -------------------------------------K---RGGLKLISEEIKEIL--KIEVSVLMGANLAPEVANDNFC 117
Cdd:PRK00094  69 ladadlilvavpsqalrevlkqlkpllppdapivwatKgiePGTGKLLSEVLEEELpdLAPIAVLSGPSFAKEVARGLPT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 118 EATIGCKRK--AEDgplLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFV 195
Cdd:PRK00094 149 AVVIASTDEelAER---VQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 196 EHYypGSNLQTFFESCGIADLITTCYG--GRNRKVCEAFVKtGKSMAEVEKELlnGQSAQGPLTAEEVYLMMHKTGLDAk 273
Cdd:PRK00094 226 VAL--GANPETFLGLAGLGDLVLTCTSplSRNRRFGLALGQ-GKSLEEALAEI--GMVAEGVRTAKAVYELAKKLGVEM- 299

                        330       340
                 ....*....|....*....|....
gi 193210134 274 fPLFTAVHKICAGEMKPAELVDCL 297
Cdd:PRK00094 300 -PITEAVYAVLYEGKDPREAVEDL 322
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-271 1.76e-30

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 117.19  E-value: 1.76e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   1 MSPKKVTIIGSGNWGSAIARIVGSTTksfpdefdPTVrMWVfeeivNGEKLSEVINNRHENIKYLP-GKVLPNNVGVSTE 79
Cdd:PRK12439   5 KREPKVVVLGGGSWGTTVASICARRG--------PTL-QWV-----RSAETADDINDNHRNSRYLGnDVVLSDTLRATTD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  80 --------------------------------------------KRGGLKLISEEIKEILKIE-VSVLMGANLAPEVAnD 114
Cdd:PRK12439  71 faeaancadvvvmgvpshgfrgvltelakelrpwvpvvslvkglEQGTNMRMSQIIEEVLPGHpAGILAGPNIAREVA-E 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 115 NFCEATIGCKRKAEDGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKF 194
Cdd:PRK12439 150 GYAAAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREMTKL 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193210134 195 VEHYypGSNLQTFFESCGIADLITTCYG--GRNRKVCEAFVKtGKSMAEVEKELlnGQSAQGPLTAEEVYLMMHKTGLD 271
Cdd:PRK12439 230 GVAM--GGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQLGA-GKPIDEIIASM--NQVAEGVKAASVVMEFADEYGLN 303
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 5-129 4.62e-30

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 111.13  E-value: 4.62e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134    5 KVTIIGSGNWGSAIARIVGSTTksfpdefdPTVRMWVFEEivngeKLSEVINNRHENIKYLPGKVLPNNVGVSTE----- 79
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNG--------HEVRLWGRDE-----ELIEEINTTHENVRYLPGIKLPENLKATTDlaeal 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   80 ---------------------------------------KRGGLKLISEEIKEILKIE--VSVLMGANLAPEVANDNFCE 118
Cdd:pfam01210  68 kgadiivivvpsqalrevlkqlkgllkpdailvslskgiEPGTLKLLSEVIEEELGIQppIAVLSGPSHAEEVAQGLPTA 147

                         170
                  ....*....|.
gi 193210134  119 ATIGCKRKAED 129
Cdd:pfam01210 148 TVIASKDEEAA 158
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 6-292 3.47e-29

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 113.43  E-value: 3.47e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   6 VTIIGSGNWGSAIAriVGSTTKSFPdefdptVRMWVfeeivNGEKLSEVINNRHENIKYLPGKVLPNNVGVSTEKR---- 81
Cdd:PRK14618   7 VAVLGAGAWGTALA--VLAASKGVP------VRLWA-----RRPEFAAALAAERENREYLPGVALPAELYPTADPEeala 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  82 --------------------------------------GGLKLISEEIKEILKIEVSVLMGANLAPEVANdNFCEATIGC 123
Cdd:PRK14618  74 gadfavvavpskalretlaglpralgyvscakglapdgGRLSELARVLEFLTQARVAVLSGPNHAEEIAR-FLPAATVVA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 124 KRKAEDGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVEHYypGSN 203
Cdd:PRK14618 153 SPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVAL--GAE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 204 LQTFFESCGIADLITTCYG--GRNRKVCEAFVKtGKSMAEVEKEllnGQSAQGPLTAEEVYLMMHKTGLDakFPLFTAVH 281
Cdd:PRK14618 231 EATFYGLSGLGDLIATATSphSRNRAAGEAIVR-GVDREHLEAG---GKVVEGLYTVKALDAWAKAHGHD--LPIVEAVA 304

                        330
                 ....*....|.
gi 193210134 282 KICAGEMKPAE 292
Cdd:PRK14618 305 RVARGGWDPLA 315
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-297 6.71e-25

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 101.60  E-value: 6.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   1 MSPKKVTIIGSGNWGSAIARIVGSTtksfpdefDPTVRMWVFEeivNGEKLSEVINNRHENIKYLPGKvlpnnvGVS--T 78
Cdd:PRK14619   2 TQPKTIAILGAGAWGSTLAGLASAN--------GHRVRVWSRR---SGLSLAAVLADADVIVSAVSMK------GVRpvA 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  79 EKRGGLKLISEEI----------------KEILKIE-----VSVLMGANLAPEVaNDNFCEATIGCKRKAEDGPLLKKLF 137
Cdd:PRK14619  65 EQVQALNLPPETIivtatkgldpettrtpSQIWQAAfpnhpVVVLSGPNLSKEI-QQGLPAATVVASRDLAAAETVQQIF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 138 HTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVEHYypGSNLQTFFESCGIADLI 217
Cdd:PRK14619 144 SSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMIRVGTHL--GAQTETFYGLSGLGDLL 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 218 TTCYG--GRNRKVCEAFVKtGKSMAEVEKELlnGQSAQGPLTAEEVYLMMHKTGLDakFPLFTAVHKICAGEMKPAELVD 295
Cdd:PRK14619 222 ATCTSplSRNYQVGYGLAQ-GKSLEQILAEL--EGTAEGVNTANVLVQLAQQQNIA--VPITEQVYRLLQGEITPQQALE 296


                 ..
gi 193210134 296 CL 297
Cdd:PRK14619 297 EL 298
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-283 8.65e-20

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 87.58  E-value: 8.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134   5 KVTIIGSGNWGSAIARIVGSTTKSfpdefdptVRMWVfeeivNGEKLSEVINNRHENIKYLPGKVLPNNVGVSTE----- 79
Cdd:PRK14620   2 KISILGAGSFGTAIAIALSSKKIS--------VNLWG-----RNHTTFESINTKRKNLKYLPTCHLPDNISVKSAidevl 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134  80 -----------------------------------------KRGGLKLISEEIKEILKIE-VSVLMGANLAPEVANDNFC 117
Cdd:PRK14620  69 sdnatciilavptqqlrticqqlqdchlkkntpilicskgiEKSSLKFPSEIVNEILPNNpIAILSGPSFAKEIAEKLPC 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 118 EATIGCKRKAEDGPLLKKLfHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVEH 197
Cdd:PRK14620 149 SIVLAGQNETLGSSLISKL-SNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTLYSA 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210134 198 YYPGSNLQTFFESCGIADLITTCYGGRNRKVCEAFvKTGKSmAEVEKELLNGQSA-QGPLTAEEVYLMMHKtgLDAKFPL 276
Cdd:PRK14620 228 KNGSIDLNTLIGPSCLGDLILTCTTLHSRNMSFGF-KIGNG-FNINQILSEGKSViEGFSTVKPLISLAKK--LNIELPI 303


                 ....*..
gi 193210134 277 FTAVHKI 283
Cdd:PRK14620 304 CESIYNL 310
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 211-280 2.01e-05

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 41.71  E-value: 2.01e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193210134  211 CGIADLITTCYGG--RNRKVCEAFVKtGKSMAEVEkellNGQSAQGPLTAEEVYLMM-HKTGLDAkfPLFTAV 280
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-GMTLAEAG----NGQVAEGVRTAKAVAAILaRAHNVEM--PILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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