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Conserved domains on  [gi|194097451|ref|NP_001123502|]
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cation channel sperm-associated protein 4 isoform 2 [Mus musculus]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
Gene Ontology:  GO:0034220|GO:0005216|GO:0005886|GO:0034702
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 126-216 7.72e-13

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 67.29  E-value: 7.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097451  126 IFWKVFSVFGVTLFGAFVPK---------HFQNMGVALYTLFICITQDGWLDIYTDFqMDEREYAMevgGAIYFAVFITL 196
Cdd:pfam00520 138 LFLFIFAIIGYQLFGGKLKTwenpdngrtNFDNFPNAFLWLFQTMTTEGWGDIMYDT-IDGKGEFW---AYIYFVSFIIL 213

                          90       100
                  ....*....|....*....|
gi 194097451  197 GAFIGLNLFVVVVTTNLEQM 216
Cdd:pfam00520 214 GGFLLLNLFIAVIIDNFQEL 233
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 126-216 7.72e-13

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 67.29  E-value: 7.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097451  126 IFWKVFSVFGVTLFGAFVPK---------HFQNMGVALYTLFICITQDGWLDIYTDFqMDEREYAMevgGAIYFAVFITL 196
Cdd:pfam00520 138 LFLFIFAIIGYQLFGGKLKTwenpdngrtNFDNFPNAFLWLFQTMTTEGWGDIMYDT-IDGKGEFW---AYIYFVSFIIL 213

                          90       100
                  ....*....|....*....|
gi 194097451  197 GAFIGLNLFVVVVTTNLEQM 216
Cdd:pfam00520 214 GGFLLLNLFIAVIIDNFQEL 233
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 126-216 7.72e-13

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 67.29  E-value: 7.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097451  126 IFWKVFSVFGVTLFGAFVPK---------HFQNMGVALYTLFICITQDGWLDIYTDFqMDEREYAMevgGAIYFAVFITL 196
Cdd:pfam00520 138 LFLFIFAIIGYQLFGGKLKTwenpdngrtNFDNFPNAFLWLFQTMTTEGWGDIMYDT-IDGKGEFW---AYIYFVSFIIL 213

                          90       100
                  ....*....|....*....|
gi 194097451  197 GAFIGLNLFVVVVTTNLEQM 216
Cdd:pfam00520 214 GGFLLLNLFIAVIIDNFQEL 233
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 123-209 3.58e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 38.41  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097451  123 GFWIFWKVFSVFGVTLFGAFVPkHFQNMGVALYTLFICITqdgwldiyTDFQMDEREYAMEVGGAIYFAVFITLGAFIGL 202
Cdd:pfam08016 141 MFVIFFFAYAQFGYLLFGTQAP-NFSNFVKSILTLFRTIL--------GDFGYNEIFSGNRVLGPLLFLTFVFLVIFILL 211


                  ....*..
gi 194097451  203 NLFVVVV 209
Cdd:pfam08016 212 NLFLAII 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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