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Conserved domains on  [gi|203096504|ref|NP_001128485|]
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ankyrin repeat domain-containing protein 42 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11430360)

ankyrin repeat (ANK) domain-containing protein mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-271 4.41e-31

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.98  E-value: 4.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  35 IHDAVRAGDVKQLSDIVERGANVNEVDAlHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACL 114
Cdd:COG0666   58 LLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 115 QALIINGANLATQDDRGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVD 194
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 203096504 195 YNGNLPVHLAAMEGHLHCFKFLLSRVNsavqALKAFNDNGENVLDLAHRFLKQNIVQFIQGAEYEGSHLDDQDDLAF 271
Cdd:COG0666  217 NDGKTALDLAAENGNLEIVKLLLEAGA----DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
202-333 1.04e-11

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  202 HLAAMEGHLHCFKFLLSRVNSAvqalKAFNDNGENVLdlahrflkqnivqfiqgaeyegshlddqddlafpgHVAAFKGD 281
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADA----NLQDKNGRTAL-----------------------------------HLAAKNGH 42

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 203096504  282 LEMLKKLIDDGVINLnerDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITN 333
Cdd:pfam12796  43 LEIVKLLLEHADVNL---KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PRK03918 super family cl35229
DNA double-strand break repair ATPase Rad50;
337-510 3.32e-04

DNA double-strand break repair ATPase Rad50;


The actual alignment was detected with superfamily member PRK03918:

Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.51  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 337 ERPSDVAKRFAHLAAvkLLEGLQKyEIDDIEGDKNHISFFIRHGVEgstdAKDDLSLSESDkanarmraHKKIVELRQLL 416
Cdd:PRK03918 307 DELREIEKRLSRLEE--EINGIEE-RIKELEEKEERLEELKKKLKE----LEKRLEELEER--------HELYEEAKAKK 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 417 EIAESNFKHLGGITEEDLKQKKELLESKKtiTELQEQLAYERLRREKLECQLDEYRVEVNQLKEALEKIQVPSAEAMEDD 496
Cdd:PRK03918 372 EELERLKKRLTGLTPEKLEKELEELEKAK--EEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEH 449

                        170
                 ....*....|....*...
gi 203096504 497 S----CEYSKEKRRMKKK 510
Cdd:PRK03918 450 RkellEEYTAELKRIEKE 467
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-271 4.41e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.98  E-value: 4.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  35 IHDAVRAGDVKQLSDIVERGANVNEVDAlHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACL 114
Cdd:COG0666   58 LLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 115 QALIINGANLATQDDRGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVD 194
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 203096504 195 YNGNLPVHLAAMEGHLHCFKFLLSRVNsavqALKAFNDNGENVLDLAHRFLKQNIVQFIQGAEYEGSHLDDQDDLAF 271
Cdd:COG0666  217 NDGKTALDLAAENGNLEIVKLLLEAGA----DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-161 2.39e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 2.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504   69 LHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACLQALIINGAnlATQDDRGCTPVHLAATHGHSFSLQ 148
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 203096504  149 VMLRSGVDPSVTD 161
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 22-235 1.03e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 76.22  E-value: 1.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  22 ADSSSRNKVPFGSIH-----DAVRAGDVKQLsdiVERGANVNEVDaLHQFTPLHW--AAHSGSLECLHWLLWNGADATQT 94
Cdd:PHA03095 108 ADVNAKDKVGRTPLHvylsgFNINPKVIRLL---LRKGADVNALD-LYGMTPLAVllKSRNANVELLRLLIDAGADVYAV 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  95 TTRGWTAAHVAA--IRGQDACLQALIINGANLATQDDRGCTPVHLAATHGHSFSLQV--MLRSGVDPSVTDKREWRPVHY 170
Cdd:PHA03095 184 DDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHY 263

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 203096504 171 AA-FHGRLGCLQLLvKWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLLSRVNSA---VQALKAFNDNGE 235
Cdd:PHA03095 264 AAvFNNPRACRRLI-ALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAetvAATLNTASVAGG 331
Ank_2 pfam12796
Ankyrin repeats (3 copies);
202-333 1.04e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  202 HLAAMEGHLHCFKFLLSRVNSAvqalKAFNDNGENVLdlahrflkqnivqfiqgaeyegshlddqddlafpgHVAAFKGD 281
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADA----NLQDKNGRTAL-----------------------------------HLAAKNGH 42

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 203096504  282 LEMLKKLIDDGVINLnerDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITN 333
Cdd:pfam12796  43 LEIVKLLLEHADVNL---KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
217-355 8.12e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.05  E-value: 8.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 217 LSRVNSAVQALKAFNDNGENVLDLAHRFLKQNIVQFIQGAEYEGSHLDDQDDLAFPGHVAAFKGDLEMLKKLIDDGVINL 296
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 203096504 297 NERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 355
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 274-355 3.54e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.66  E-value: 3.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 274 HVAAFKGDLEMLKKLIDDGViNLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVK 353
Cdd:PHA02874 129 HYAIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207


                 ..
gi 203096504 354 LL 355
Cdd:PHA02874 208 LL 209
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 67-220 3.94e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.16  E-value: 3.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  67 TPLHWAAHSGSLECLHWLL-WNGADATQTTTRGWTAAHVAAIRGQDACLQALIING---ANLATQDD--RGCTPVHLAAT 140
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLkCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQGETALHIAVV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 141 HGHSFSLQVMLRSGVD---PSVTDK--REWR---------PVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAM 206
Cdd:cd22192   99 NQNLNLVRELIARGADvvsPRATGTffRPGPknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVL 178

                        170
                 ....*....|....*...
gi 203096504 207 EGH--LHC--FKFLLSRV 220
Cdd:cd22192  179 QPNktFACqmYDLILSYD 196
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
337-510 3.32e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.51  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 337 ERPSDVAKRFAHLAAvkLLEGLQKyEIDDIEGDKNHISFFIRHGVEgstdAKDDLSLSESDkanarmraHKKIVELRQLL 416
Cdd:PRK03918 307 DELREIEKRLSRLEE--EINGIEE-RIKELEEKEERLEELKKKLKE----LEKRLEELEER--------HELYEEAKAKK 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 417 EIAESNFKHLGGITEEDLKQKKELLESKKtiTELQEQLAYERLRREKLECQLDEYRVEVNQLKEALEKIQVPSAEAMEDD 496
Cdd:PRK03918 372 EELERLKKRLTGLTPEKLEKELEELEKAK--EEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEH 449

                        170
                 ....*....|....*...
gi 203096504 497 S----CEYSKEKRRMKKK 510
Cdd:PRK03918 450 RkellEEYTAELKRIEKE 467
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 302-331 4.04e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 4.04e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 203096504   302 NGSTPMHKAAGQGHIDCLQWLVEMGADSNI 331
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-90 6.86e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 6.86e-04
                           10        20
                   ....*....|....*....|....*..
gi 203096504    64 HQFTPLHWAAHSGSLECLHWLLWNGAD 90
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 402-508 7.16e-04

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 39.52  E-value: 7.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  402 RMRAHKKIVELRQLLEIAEsnfkhlggitEEDLKQKKELLESKKTITELQEQLAYERLRREKLECQLDEYRVEVNQLKEA 481
Cdd:pfam20492   1 REEAEREKQELEERLKQYE----------EETKKAQEELEESEETAEELEEERRQAEEEAERLEQKRQEAEEEKERLEES 70

                          90       100
                  ....*....|....*....|....*..
gi 203096504  482 LEKIQVpSAEAMEDDSCEYSKEKRRMK 508
Cdd:pfam20492  71 AEMEAE-EKEQLEAELAEAQEEIARLE 96
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
407-486 4.53e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.50  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 407 KKIVELRQLLEIAESNFKHLggitEEDLKQ-KKELLESKKTITELQEQLAYERLRREKLECQLDEYRVEVNQLKEALEKI 485
Cdd:COG4372   45 EELEQLREELEQAREELEQL----EEELEQaRSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEEL 120


                 .
gi 203096504 486 Q 486
Cdd:COG4372  121 Q 121
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 344-487 9.94e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 38.07  E-value: 9.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504   344 KRFAHLAA--------VKLLEGLQK--YEIDDI-EGDKNHISFFIrhgvEGSTDAKDDLSlsesDKANARMRahkKIVEL 412
Cdd:smart00787 123 KTFARLEAkkmwyewrMKLLEGLKEglDENLEGlKEDYKLLMKEL----ELLNSIKPKLR----DRKDALEE---ELRQL 191

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 203096504   413 RQLL-EIAESNFKHLGGITEEDLKQKKELLESKKTITELQEQLAYERLRREKLECQLDEYRVEVNQLKEALEKIQV 487
Cdd:smart00787 192 KQLEdELEDCDPTELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG 267
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-271 4.41e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.98  E-value: 4.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  35 IHDAVRAGDVKQLSDIVERGANVNEVDAlHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACL 114
Cdd:COG0666   58 LLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 115 QALIINGANLATQDDRGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVD 194
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 203096504 195 YNGNLPVHLAAMEGHLHCFKFLLSRVNsavqALKAFNDNGENVLDLAHRFLKQNIVQFIQGAEYEGSHLDDQDDLAF 271
Cdd:COG0666  217 NDGKTALDLAAENGNLEIVKLLLEAGA----DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-371 6.30e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.13  E-value: 6.30e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  47 LSDIVERGANVNEVDALHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACLQALIINGANLAT 126
Cdd:COG0666    3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 127 QDDRGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAM 206
Cdd:COG0666   83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 207 EGHLHCFKFLLSR---VNsavqalkAFNDNGENVLdlahrflkqnivqfiqgaeyegshlddqddlafpgHVAAFKGDLE 283
Cdd:COG0666  163 NGNLEIVKLLLEAgadVN-------ARDNDGETPL-----------------------------------HLAAENGHLE 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 284 MLKKLIDDGViNLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLLEGLQKYEI 363
Cdd:COG0666  201 IVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279


                 ....*...
gi 203096504 364 DDIEGDKN 371
Cdd:COG0666  280 AALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
84-406 1.83e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.97  E-value: 1.83e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  84 LLWNGADATQTTTRGWTAAHVAAIRGQDACLQALIINGANLATQDDRGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKR 163
Cdd:COG0666    7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 164 EWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLLSR---VNSAvqalkafNDNGENVLdl 240
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAgadVNAQ-------DNDGNTPL-- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 241 ahrflkqnivqfiqgaeyegshlddqddlafpgHVAAFKGDLEMLKKLIDDGViNLNERDENGSTPMHKAAGQGHIDCLQ 320
Cdd:COG0666  158 ---------------------------------HLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVK 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 321 WLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLLEGLQKYEIDDIEGDKNHISFFIRHGVEGSTDAKDDLSLSESDKAN 400
Cdd:COG0666  204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283


                 ....*.
gi 203096504 401 ARMRAH 406
Cdd:COG0666  284 DLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-199 1.46e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 97.72  E-value: 1.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  22 ADSSSRNKVPFGSIHDAVRAGDVKQLSDIVERGANVNEVDAlHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTA 101
Cdd:COG0666  111 ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETP 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 102 AHVAAIRGQDACLQALIINGANLATQDDRGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQ 181
Cdd:COG0666  190 LHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVK 269

                        170
                 ....*....|....*...
gi 203096504 182 LLVKWGCGIEDVDYNGNL 199
Cdd:COG0666  270 LLLLALLLLAAALLDLLT 287
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-161 2.39e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 2.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504   69 LHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACLQALIINGAnlATQDDRGCTPVHLAATHGHSFSLQ 148
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 203096504  149 VMLRSGVDPSVTD 161
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 22-235 1.03e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 76.22  E-value: 1.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  22 ADSSSRNKVPFGSIH-----DAVRAGDVKQLsdiVERGANVNEVDaLHQFTPLHW--AAHSGSLECLHWLLWNGADATQT 94
Cdd:PHA03095 108 ADVNAKDKVGRTPLHvylsgFNINPKVIRLL---LRKGADVNALD-LYGMTPLAVllKSRNANVELLRLLIDAGADVYAV 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  95 TTRGWTAAHVAA--IRGQDACLQALIINGANLATQDDRGCTPVHLAATHGHSFSLQV--MLRSGVDPSVTDKREWRPVHY 170
Cdd:PHA03095 184 DDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHY 263

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 203096504 171 AA-FHGRLGCLQLLvKWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLLSRVNSA---VQALKAFNDNGE 235
Cdd:PHA03095 264 AAvFNNPRACRRLI-ALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAetvAATLNTASVAGG 331
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 39-346 2.62e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 75.00  E-value: 2.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  39 VRAGDVKQLSDIVERGANVNEVDALHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACLQALI 118
Cdd:PHA02874   9 IYSGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 119 INGAnlatqdDRGCTPVHLAATHghsfSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGN 198
Cdd:PHA02874  89 DNGV------DTSILPIPCIEKD----MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGC 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 199 LPVHLAAMEGHLHCFKFLLSrvNSAVQALKafNDNGENVLDLAHRFLKQNIVQFIQGaeyEGSHLDDQDDLAF-PGHVAA 277
Cdd:PHA02874 159 YPIHIAIKHNFFDIIKLLLE--KGAYANVK--DNNGESPLHNAAEYGDYACIKLLID---HGNHIMNKCKNGFtPLHNAI 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 278 FKgDLEMLKKLIDDGVInlNERDENGSTPMHKAAGQG-HIDCLQWLVEMGADSNITNKAGERPSDVAKRF 346
Cdd:PHA02874 232 IH-NRSAIELLINNASI--NDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKY 298
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 132-355 7.59e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.55  E-value: 7.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 132 CTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHG-RLGC----LQLLVKWGCGIEDVDYNGNLPVHLAAM 206
Cdd:PHA03100  36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKyNLTDvkeiVKLLLEYGANVNAPDNNGITPLLYAIS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 207 E--GHLHCFKFLLSRvNSAVQALkafNDNGENVLdlaHRFLKQNivqfiqgaeyegshlddqddlafpghvaafKGDLEM 284
Cdd:PHA03100 116 KksNSYSIVEYLLDN-GANVNIK---NSDGENLL---HLYLESN------------------------------KIDLKI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 285 LKKLIDDGV---------------INLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHL 349
Cdd:PHA03100 159 LKLLIDKGVdinaknrvnyllsygVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238


                 ....*.
gi 203096504 350 AAVKLL 355
Cdd:PHA03100 239 EIFKLL 244
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 50-250 8.50e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 73.46  E-value: 8.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  50 IVERGANVNEVDALHQfTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACLQALIINGANLATQDD 129
Cdd:PHA02874 110 ILDCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 130 RGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRlGCLQLLVKwGCGIEDVDYNGNLPVHLAAmegH 209
Cdd:PHA02874 189 NGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLIN-NASINDQDIDGSTPLHHAI---N 263

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 203096504 210 LHCFKFLLSRV--NSAVQALKafNDNGENVLDLAHRFLKQNIV 250
Cdd:PHA02874 264 PPCDIDIIDILlyHKADISIK--DNKGENPIDTAFKYINKDPV 304
Ank_2 pfam12796
Ankyrin repeats (3 copies);
35-128 1.82e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504   35 IHDAVRAGDVKQLSDIVERGANVNEVDALHQfTPLHWAAHSGSLECLHWLLwNGADAtQTTTRGWTAAHVAAIRGQDACL 114
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGR-TALHLAAKNGHLEIVKLLL-EHADV-NLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 203096504  115 QALIINGANLATQD 128
Cdd:pfam12796  78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
136-219 2.01e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 2.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  136 HLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKwgCGIEDVDYNGNLPVHLAAMEGHLHCFKF 215
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTALHYAARSGHLEIVKL 79


                  ....
gi 203096504  216 LLSR 219
Cdd:pfam12796  80 LLEK 83
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 138-363 2.31e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 69.51  E-value: 2.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 138 AATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLl 217
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL- 610

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 218 srvnsavqalkafndngenvldlahrflkqnivqfiqgaeYEGSHLDDQ----DDLAFpghvAAFKGDLEMLKKLIDDGv 293
Cdd:PLN03192 611 ----------------------------------------YHFASISDPhaagDLLCT----AAKRNDLTAMKELLKQG- 645

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 294 INLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADsnitnkagerpSDVAKRFAHLAAVKLLEGLQKYEI 363
Cdd:PLN03192 646 LNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD-----------VDKANTDDDFSPTELRELLQKREL 704
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 35-187 2.58e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.48  E-value: 2.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  35 IHDAVRAGDVKQLSDIVERGANVNEVDALHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACL 114
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 203096504 115 QALIINGANLATQDDRGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKR-EWRPVHYAAFHGRLGCLQLLVKWG 187
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRG 225
Ank_2 pfam12796
Ankyrin repeats (3 copies);
202-333 1.04e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  202 HLAAMEGHLHCFKFLLSRVNSAvqalKAFNDNGENVLdlahrflkqnivqfiqgaeyegshlddqddlafpgHVAAFKGD 281
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADA----NLQDKNGRTAL-----------------------------------HLAAKNGH 42

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 203096504  282 LEMLKKLIDDGVINLnerDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITN 333
Cdd:pfam12796  43 LEIVKLLLEHADVNL---KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 37-204 1.47e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.53  E-value: 1.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  37 DAVRAGDVKQLSDIVERGANVNEVDAlHQFTPLHWAAHSGSLECLHWLLWNGADAT--------------------QTTT 96
Cdd:PHA02874  41 DAIRSGDAKIVELFIKHGADINHINT-KIPHPLLTAIKIGAHDIIKLLIDNGVDTSilpipciekdmiktildcgiDVNI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  97 RGW---TAAHVAAIRGQDACLQALIINGANLATQDDRGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAF 173
Cdd:PHA02874 120 KDAelkTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAE 199

                        170       180       190
                 ....*....|....*....|....*....|.
gi 203096504 174 HGRLGCLQLLVKWGCGIEDVDYNGNLPVHLA 204
Cdd:PHA02874 200 YGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
274-355 1.73e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.51  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  274 HVAAFKGDLEMLKKLIDDGViNLNERDENGSTPMHKAAGQGHIDCLQWLVEmGADSNITNKaGERPSDVAKRFAHLAAVK 353
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78


                  ..
gi 203096504  354 LL 355
Cdd:pfam12796  79 LL 80
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 41-233 2.30e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.84  E-value: 2.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  41 AGDVKQLSDI-VERGANVNEVDAlHQFTPLHWAA--HSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQD--ACLQ 115
Cdd:PHA03100  82 LTDVKEIVKLlLEYGANVNAPDN-NGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILK 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 116 ALIINGANLATQDdrgctpvhlaathghsfSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDY 195
Cdd:PHA03100 161 LLIDKGVDINAKN-----------------RVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 203096504 196 NGNLPVHLAAMEGHLHCFKFLLSR---VNSAVQALKAFNDN 233
Cdd:PHA03100 224 YGDTPLHIAILNNNKEIFKLLLNNgpsIKTIIETLLYFKDK 264
Ank_2 pfam12796
Ankyrin repeats (3 copies);
169-253 4.28e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.36  E-value: 4.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  169 HYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLLSRVNSAVQalkafnDNGENVLDLAHRFLKQN 248
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK------DNGRTALHYAARSGHLE 75


                  ....*
gi 203096504  249 IVQFI 253
Cdd:pfam12796  76 IVKLL 80
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-339 7.33e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.28  E-value: 7.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  39 VRAGDVKQLsdiVERGANVNEVDALHQfTPLHWAAHSGSLEC---LHWLLWNGADATQTTTRGWTAAH-------VAAIr 108
Cdd:PHA03095  25 VTVEEVRRL---LAAGADVNFRGEYGK-TPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHlylynatTLDV- 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 109 gqdacLQALIINGANLATQDDRGCTP--VHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVH-YAAFHG-RLGCLQLLV 184
Cdd:PHA03095 100 -----IKLLIKAGADVNAKDKVGRTPlhVYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAvLLKSRNaNVELLRLLI 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 185 KWGCGIEDVDYNGNLPVHlaameghlhcfKFLLS-RVNSAVqalkaFNDNGENVLDLAHRFLKQNIvqfiqgaeyegshl 263
Cdd:PHA03095 175 DAGADVYAVDDRFRSLLH-----------HHLQSfKPRARI-----VRELIRAGCDPAATDMLGNT-------------- 224

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 203096504 264 ddqddlafPGHVAAFKGDLEMLK--KLIDDGVInLNERDENGSTPMHKAAGQG-HIDCLQwLVEMGADSNITNKAGERP 339
Cdd:PHA03095 225 --------PLHSMATGSSCKRSLvlPLLIAGIS-INARNRYGQTPLHYAAVFNnPRACRR-LIALGADINAVSSDGNTP 293
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
217-355 8.12e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.05  E-value: 8.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 217 LSRVNSAVQALKAFNDNGENVLDLAHRFLKQNIVQFIQGAEYEGSHLDDQDDLAFPGHVAAFKGDLEMLKKLIDDGVINL 296
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 203096504 297 NERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 355
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
Ank_4 pfam13637
Ankyrin repeats (many copies);
274-323 1.84e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.13  E-value: 1.84e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 203096504  274 HVAAFKGDLEMLKKLIDDGViNLNERDENGSTPMHKAAGQGHIDCLQWLV 323
Cdd:pfam13637   6 HAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-204 4.17e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.39  E-value: 4.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  34 SIHDAVRAGDVKQLSDIVERGANVNEVDaLHQFTPLHWAAHSGSLECL-HWLLWNGADATQTTTRGWTAAHVAAIRGQDA 112
Cdd:PHA02876 243 SLLKAIRNEDLETSLLLYDAGFSVNSID-DCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYDT 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 113 -CLQALIINGANLATQDDRGCTPVHLAATHGHSFSLQV-MLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGI 190
Cdd:PHA02876 322 eNIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401

                        170
                 ....*....|....
gi 203096504 191 EDVDYNGNLPVHLA 204
Cdd:PHA02876 402 EALSQKIGTALHFA 415
Ank_4 pfam13637
Ankyrin repeats (many copies);
67-118 1.14e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.20  E-value: 1.14e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 203096504   67 TPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACLQALI 118
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
164-217 1.60e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.82  E-value: 1.60e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 203096504  164 EWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLL 217
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
288-343 1.12e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.19  E-value: 1.12e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 203096504  288 LIDDGVINLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVA 343
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-359 3.50e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.23  E-value: 3.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  34 SIHDAVRAGDVKQLSDIVERGANVNEVDaLHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDAC 113
Cdd:PHA02876 148 LIKERIQQDELLIAEMLLEGGADVNAKD-IYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDT 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 114 LQALIINGANLATQDDRgctpvHLAATHGHSFSLQVML-RSGVDPSVTDKREWRPVHYAAFHGRLGCL-QLLVKWGCGIE 191
Cdd:PHA02876 227 IKAIIDNRSNINKNDLS-----LLKAIRNEDLETSLLLyDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVN 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 192 DVDYNGNLPVHLAAMEGH-LHCFKFLLSR---VNSA----------VQALKAFNDNGENVLDLA--------------HR 243
Cdd:PHA02876 302 AKNIKGETPLYLMAKNGYdTENIRTLIMLgadVNAAdrlyitplhqASTLDRNKDIVITLLELGanvnardycdktpiHY 381

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 244 FLKQNIVQFIQ-----GAEYEGshLDDQDDLAFpgHVAAFKGDLEM-LKKLIDDGViNLNERDENGSTPMHKAAGQG-HI 316
Cdd:PHA02876 382 AAVRNNVVIINtlldyGADIEA--LSQKIGTAL--HFALCGTNPYMsVKTLIDRGA-NVNSKNKDLSTPLHYACKKNcKL 456

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 203096504 317 DCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLLEGLQ 359
Cdd:PHA02876 457 DVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNILLHYGAE 499
Ank_4 pfam13637
Ankyrin repeats (many copies);
133-184 4.92e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 4.92e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 203096504  133 TPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLV 184
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 24-204 5.41e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 55.27  E-value: 5.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  24 SSSRNKVPFGSIHDAVRAGDVKQLSDIVERGANVNEVDalHQF-TPLHW------------------------------- 71
Cdd:PHA02878  30 STSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPD--HRDlTPLHIickepnklgmkemirsinkcsvfytlvaikd 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  72 AAHSGSLECLHWLLWNGADATQTTTrgwtaahVAAIR--GQDACLQALIIN-----GANLATQD-DRGCTPVHLAATHGH 143
Cdd:PHA02878 108 AFNNRNVEIFKIILTNRYKNIQTID-------LVYIDkkSKDDIIEAEITKlllsyGADINMKDrHKGNTALHYATENKD 180

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 203096504 144 SFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLA 204
Cdd:PHA02878 181 QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-143 7.08e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 7.08e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 203096504   98 GWTAAHVAAIRGQDACLQALIINGANLATQDDRGCTPVHLAATHGH 143
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
Ank_4 pfam13637
Ankyrin repeats (many copies);
303-355 1.26e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 1.26e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 203096504  303 GSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 355
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 116-352 1.45e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.88  E-value: 1.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 116 ALIINGANLATQDDRGCTPVHlaaTHGHSFS------LQVMLRSGVDPSVTDKREWRPVH-YAAFHGRLGCLQLLVKWGC 188
Cdd:PHA03095  32 RLLAAGADVNFRGEYGKTPLH---LYLHYSSekvkdiVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 189 GIEDVDYNGNLP--VHLAAMEGHLHCFKFLLsRVNSAVQALKAFNDNGenvldlAHRFLKQN-----IVQFIQGAEYEGS 261
Cdd:PHA03095 109 DVNAKDKVGRTPlhVYLSGFNINPKVIRLLL-RKGADVNALDLYGMTP------LAVLLKSRnanveLLRLLIDAGADVY 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 262 HLDDQDDLAFPGHVAAFKGDLEMLKKLIDDGViNLNERDENGSTPMHKAAGQG---HIDCLQwLVEMGADSNITNKAGER 338
Cdd:PHA03095 182 AVDDRFRSLLHHHLQSFKPRARIVRELIRAGC-DPAATDMLGNTPLHSMATGSsckRSLVLP-LLIAGISINARNRYGQT 259

                        250
                 ....*....|....
gi 203096504 339 PsdvakrfAHLAAV 352
Cdd:PHA03095 260 P-------LHYAAV 266
Ank_4 pfam13637
Ankyrin repeats (many copies);
35-85 1.69e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 1.69e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 203096504   35 IHDAVRAGDVKQLSDIVERGANVNEVDALhQFTPLHWAAHSGSLECLHWLL 85
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGN-GETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 50-233 2.41e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.35  E-value: 2.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  50 IVERGANVNEVDALHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACLQALIINGANLATQDD 129
Cdd:PHA02878 153 LLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDK 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 130 RGCTPVHLAATHGHSFS-LQVMLRSGVDPSVTDK-REWRPVHYAAFHGRLgcLQLLVKWGCGIEDVDYNGNLPVHLAAME 207
Cdd:PHA02878 233 CGNTPLHISVGYCKDYDiLKLLLEHGVDVNAKSYiLGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSAVKQ 310

                        170       180       190
                 ....*....|....*....|....*....|...
gi 203096504 208 GH-LHCFKFLLS------RVNSAVQALKAFNDN 233
Cdd:PHA02878 311 YLcINIGRILISnicllkRIKPDIKNSEGFIDN 343
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 54-217 3.45e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 52.95  E-value: 3.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  54 GANVNEVDALHQFTplhwAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACLQALIINGANLATQDDRGCT 133
Cdd:PLN03192 518 GEHDDPNMASNLLT----VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNT 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 134 PV--HLAATHGHSFSLQVMLRSGVDPSVTDKRewrpVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAMEGHLH 211
Cdd:PLN03192 594 ALwnAISAKHHKIFRILYHFASISDPHAAGDL----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVD 669


                 ....*.
gi 203096504 212 CFKFLL 217
Cdd:PLN03192 670 MVRLLI 675
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 274-355 3.54e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.66  E-value: 3.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 274 HVAAFKGDLEMLKKLIDDGViNLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVK 353
Cdd:PHA02874 129 HYAIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207


                 ..
gi 203096504 354 LL 355
Cdd:PHA02874 208 LL 209
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 274-371 5.92e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 5.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 274 HVAAfKGDLEMLKKLIDDGViNLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVK 353
Cdd:PTZ00322  88 QLAA-SGDAVGARILLTGGA-DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*...
gi 203096504 354 LLEGlqkYEIDDIEGDKN 371
Cdd:PTZ00322 166 LLSR---HSQCHFELGAN 180
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 131-336 1.34e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.76  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 131 GCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDY-NGNLPVHLAAMEGH 209
Cdd:PHA02875  35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYkDGMTPLHLATILKK 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 210 LHCFKFLLSRvnsavqalkafndngenvldlahrflkqnivqfiqGAEYEGSHLDDQDDLafpgHVAAFKGDLEMLKKLI 289
Cdd:PHA02875 115 LDIMKLLIAR-----------------------------------GADPDIPNTDKFSPL----HLAVMMGDIKGIELLI 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 203096504 290 DDGVInLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAG 336
Cdd:PHA02875 156 DHKAC-LDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG 201
Ank_5 pfam13857
Ankyrin repeats (many copies);
50-105 2.85e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.64  E-value: 2.85e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 203096504   50 IVERGANVNEVDALHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVA 105
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 103-200 3.70e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 103 HVAAiRGQDACLQALIINGANLATQDDRGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 182
Cdd:PTZ00322  88 QLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166

                         90
                 ....*....|....*...
gi 203096504 183 LVkwGCGIEDVDYNGNLP 200
Cdd:PTZ00322 167 LS--RHSQCHFELGANAK 182
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 50-192 1.20e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  50 IVERGANVNEVDALHQfTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAaIRGQD--ACLQALIINGANLATQ 127
Cdd:PHA02876 361 LLELGANVNARDYCDK-TPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA-LCGTNpyMSVKTLIDRGANVNSK 438

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 203096504 128 DDRGCTPVHLAATHGHSFS-LQVMLRSGVDPSVTDKREWRPVHYA-AFHgrlGCLQLLVKWGCGIED 192
Cdd:PHA02876 439 NKDLSTPLHYACKKNCKLDvIEMLLDNGADVNAINIQNQYPLLIAlEYH---GIVNILLHYGAELRD 502
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 167-339 2.21e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.80  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 167 PVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLLSRVNS-----AVQALK-AFNDNGENVLD- 239
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKcsvfyTLVAIKdAFNNRNVEIFKi 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 240 -LAHRFLKQ---NIVQ------------------FIQGAEyegSHLDDQDDLAFPGHVAAFKGDLEMLKKLIDDGViNLN 297
Cdd:PHA02878 120 iLTNRYKNIqtiDLVYidkkskddiieaeitkllLSYGAD---INMKDRHKGNTALHYATENKDQRLTELLLSYGA-NVN 195

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 203096504 298 ERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERP 339
Cdd:PHA02878 196 IPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 123-218 2.29e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 2.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 123 NLATQDDRGCTPVH--------LAAThGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVD 194
Cdd:PTZ00322  67 NLTTEEVIDPVVAHmltvelcqLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLD 145

                         90       100
                 ....*....|....*....|....
gi 203096504 195 YNGNLPVHLAAMEGHLHCFKFLLS 218
Cdd:PTZ00322 146 KDGKTPLELAEENGFREVVQLLSR 169
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 67-220 3.94e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.16  E-value: 3.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  67 TPLHWAAHSGSLECLHWLL-WNGADATQTTTRGWTAAHVAAIRGQDACLQALIING---ANLATQDD--RGCTPVHLAAT 140
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLkCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQGETALHIAVV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 141 HGHSFSLQVMLRSGVD---PSVTDK--REWR---------PVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAM 206
Cdd:cd22192   99 NQNLNLVRELIARGADvvsPRATGTffRPGPknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVL 178

                        170
                 ....*....|....*...
gi 203096504 207 EGH--LHC--FKFLLSRV 220
Cdd:cd22192  179 QPNktFACqmYDLILSYD 196
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 302-334 4.48e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 4.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 203096504  302 NGSTPMHKAAGQ-GHIDCLQWLVEMGADSNITNK 334
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
89-138 2.22e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 2.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 203096504   89 ADATQTTTRGWTAAHVAAIRGQDACLQALIINGANLATQDDRGCTPVHLA 138
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
337-510 3.32e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.51  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 337 ERPSDVAKRFAHLAAvkLLEGLQKyEIDDIEGDKNHISFFIRHGVEgstdAKDDLSLSESDkanarmraHKKIVELRQLL 416
Cdd:PRK03918 307 DELREIEKRLSRLEE--EINGIEE-RIKELEEKEERLEELKKKLKE----LEKRLEELEER--------HELYEEAKAKK 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 417 EIAESNFKHLGGITEEDLKQKKELLESKKtiTELQEQLAYERLRREKLECQLDEYRVEVNQLKEALEKIQVPSAEAMEDD 496
Cdd:PRK03918 372 EELERLKKRLTGLTPEKLEKELEELEKAK--EEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEH 449

                        170
                 ....*....|....*...
gi 203096504 497 S----CEYSKEKRRMKKK 510
Cdd:PRK03918 450 RkellEEYTAELKRIEKE 467
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 302-331 4.04e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 4.04e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 203096504   302 NGSTPMHKAAGQGHIDCLQWLVEMGADSNI 331
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 302-331 4.59e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.62  E-value: 4.59e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 203096504  302 NGSTPMHKAAGQGHIDCLQWLVEMGADSNI 331
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 37-258 6.41e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.29  E-value: 6.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  37 DAVRAGDVKQLSDIVERGANVNeVDALHQFTPLHWAAHSGSLECLHWLLWNGADATQTTTRGWTAAHVAAIRGQDACLQA 116
Cdd:PHA02875   8 DAILFGELDIARRLLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 117 LIINGANLatqDD----RGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIED 192
Cdd:PHA02875  87 LLDLGKFA---DDvfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 203096504 193 VDYNGNLPVHLAAMEGHLHCFKFLLSR--------VNSAVQALKAFNDNgeNVLDLAHRFLKQ----NIVQFIQGAEY 258
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIAICKMLLDSganidyfgKNGCVAALCYAIEN--NKIDIVRLFIKRgadcNIMFMIEGEEC 239
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-90 6.86e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 6.86e-04
                           10        20
                   ....*....|....*....|....*..
gi 203096504    64 HQFTPLHWAAHSGSLECLHWLLWNGAD 90
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 402-508 7.16e-04

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 39.52  E-value: 7.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504  402 RMRAHKKIVELRQLLEIAEsnfkhlggitEEDLKQKKELLESKKTITELQEQLAYERLRREKLECQLDEYRVEVNQLKEA 481
Cdd:pfam20492   1 REEAEREKQELEERLKQYE----------EETKKAQEELEESEETAEELEEERRQAEEEAERLEQKRQEAEEEKERLEES 70

                          90       100
                  ....*....|....*....|....*..
gi 203096504  482 LEKIQVpSAEAMEDDSCEYSKEKRRMK 508
Cdd:pfam20492  71 AEMEAE-EKEQLEAELAEAQEEIARLE 96
PHA02798 PHA02798
ankyrin-like protein; Provisional
 117-337 1.20e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.36  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 117 LIINGANLATQDDRGCTPVHLAATHGHSFSLQV---MLRSGVDPSVTDKREWRpvhyaafhgrlgCLQLLVKWGCGIE-- 191
Cdd:PHA02798  95 LIENGADINKKNSDGETPLYCLLSNGYINNLEIllfMIENGADTTLLDKDGFT------------MLQVYLQSNHHIDie 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 192 ----------DVDYNGNlpvhlaaMEGH--LHC-FKFLLSRVNsaVQALKAFNDNGEnvldLAHRFLKQNIVQFIqgaEY 258
Cdd:PHA02798 163 iiklllekgvDINTHNN-------KEKYdtLHCyFKYNIDRID--ADILKLFVDNGF----IINKENKSHKKKFM---EY 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 259 EGSHLDDQddlafpghvaafkgdlEMLKKLIDDGV---INLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKA 335
Cdd:PHA02798 227 LNSLLYDN----------------KRFKKNILDFIfsyIDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITEL 290


                 ..
gi 203096504 336 GE 337
Cdd:PHA02798 291 GN 292
Ank_5 pfam13857
Ankyrin repeats (many copies);
122-171 1.33e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 1.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 203096504  122 ANLATQDDRGCTPVHLAATHGHSFSLQVMLRSGVDPSVTDKREWRPVHYA 171
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 283-355 1.42e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 1.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 203096504 283 EMLKKLIDDGvINLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 355
Cdd:PHA02874 105 DMIKTILDCG-IDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLL 176
Ank_2 pfam12796
Ankyrin repeats (3 copies);
307-371 2.29e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 2.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 203096504  307 MHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLLegLQKYEIDDIEGDKN 371
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDNGRT 63
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 64-95 4.46e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 4.46e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 203096504   64 HQFTPLHWAA-HSGSLECLHWLLWNGADATQTT 95
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
407-486 4.53e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.50  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 407 KKIVELRQLLEIAESNFKHLggitEEDLKQ-KKELLESKKTITELQEQLAYERLRREKLECQLDEYRVEVNQLKEALEKI 485
Cdd:COG4372   45 EELEQLREELEQAREELEQL----EEELEQaRSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEEL 120


                 .
gi 203096504 486 Q 486
Cdd:COG4372  121 Q 121
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
407-509 7.23e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 39.28  E-value: 7.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504 407 KKIVELRQLLEIAESNFKHLGGITEEDLKQKKELLESKKTITELQEQLAYERLRREKLECQLDEYRVEVNQLKEALEKiq 486
Cdd:PRK03918 214 SELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEK-- 291

                         90       100
                 ....*....|....*....|...
gi 203096504 487 VPSAEAMEDDSCEYSKEKRRMKK 509
Cdd:PRK03918 292 AEEYIKLSEFYEEYLDELREIEK 314
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 196-219 9.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 9.02e-03
                           10        20
                   ....*....|....*....|....
gi 203096504   196 NGNLPVHLAAMEGHLHCFKFLLSR 219
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK 24
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 344-487 9.94e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 38.07  E-value: 9.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 203096504   344 KRFAHLAA--------VKLLEGLQK--YEIDDI-EGDKNHISFFIrhgvEGSTDAKDDLSlsesDKANARMRahkKIVEL 412
Cdd:smart00787 123 KTFARLEAkkmwyewrMKLLEGLKEglDENLEGlKEDYKLLMKEL----ELLNSIKPKLR----DRKDALEE---ELRQL 191

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 203096504   413 RQLL-EIAESNFKHLGGITEEDLKQKKELLESKKTITELQEQLAYERLRREKLECQLDEYRVEVNQLKEALEKIQV 487
Cdd:smart00787 192 KQLEdELEDCDPTELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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