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Conserved domains on  [gi|209364568|ref|NP_001129232|]
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protein HIRA [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 778-960 2.32e-58

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


:

Pssm-ID: 462211  Cd Length: 221  Bit Score: 199.77  E-value: 2.32e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   778 LHCTGPYVMALTAAATLSVWDVHRQVVVVKEESLHSILSGS---------DMTVSQILLTQHGIPVMNLSDGKAYCFNPS 848
Cdd:pfam07569   17 LECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGVPIVTLSNGDGYLYDKS 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   849 LSTWNLVSDKQDSLA-QCADFRNSLPSQDAMLCSGPLAIIQGRTSN--SGRQAARLFSVPHVV----------QQESTLA 915
Cdd:pfam07569   97 LETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLERKTNEelLRKGRGRLLQRLAKTllmkegfenfETVVTLA 176

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 209364568   916 YLESQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRLREICQDL 960
Cdd:pfam07569  177 HLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
3-352 6.57e-42

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.92  E-value: 6.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568    3 LLKPTWVNHNGkPIFSVDIHPDGTKFATGGqgqDSGKVVIWNMSPvlqeddekdeniPKMLCQMDNHLACVNCVRWSNSG 82
Cdd:COG2319   111 LLLRTLTGHTG-AVRSVAFSPDGKTLASGS---ADGTVRLWDLAT------------GKLLRTLTGHSGAVTSVAFSPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   83 MYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNaVK 162
Cdd:COG2319   175 KLLASGSDDGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-LA 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  163 FPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRLSWSPDGHYLVSAha 242
Cdd:COG2319   235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSVAFSPDGKLLASG-- 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  243 mnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpscpycccAVGSKDRSLSVWLTCLKRPLVV 322
Cdd:COG2319   307 --SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKTL---------ASGSDDGTVRLWDLATGELLRT 367

                         330       340       350
                  ....*....|....*....|....*....|
gi 209364568  323 IHElFDKSIMDISWTLNGLGILVCSMDGSV 352
Cdd:COG2319   368 LTG-HTGAVTSVAFSPDGRTLASGSADGTV 396
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
467-630 1.16e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14950:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  467 AQLDtGDFSTAFFNSIPLSSSLAGTMLSSPSGQQLLPLDSSTPSFGASK--PCTEPVAATSAR-PTGEPVSKDSMNATST 543
Cdd:PRK14950  335 SQLD-FQLRTTSYGQLPLELAVIEALLVPVPAPQPAKPTAAAPSPVRPTpaPSTRPKAAAAANiPPKEPVRETATPPPVP 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  544 PAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPSLTSVIP-----TAVERLKE--QNLVRELRSRE-----LDSS-- 609
Cdd:PRK14950  414 PRPVAPPVPHTPESAPKLTRAAIPVDEKPKYTPPAPPKEEEKAliadgDVLEQLEAiwKQILRDVPPRSpavqaLLSSgv 493

                         170       180
                  ....*....|....*....|....
gi 209364568  610 ---SDSDEKVHLAKPSSLSKRKLE 630
Cdd:PRK14950  494 rpvSVEKNTLTLSFKSKFHKDKIE 517
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 778-960 2.32e-58

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 199.77  E-value: 2.32e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   778 LHCTGPYVMALTAAATLSVWDVHRQVVVVKEESLHSILSGS---------DMTVSQILLTQHGIPVMNLSDGKAYCFNPS 848
Cdd:pfam07569   17 LECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGVPIVTLSNGDGYLYDKS 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   849 LSTWNLVSDKQDSLA-QCADFRNSLPSQDAMLCSGPLAIIQGRTSN--SGRQAARLFSVPHVV----------QQESTLA 915
Cdd:pfam07569   97 LETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLERKTNEelLRKGRGRLLQRLAKTllmkegfenfETVVTLA 176

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 209364568   916 YLESQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRLREICQDL 960
Cdd:pfam07569  177 HLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
3-352 6.57e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.92  E-value: 6.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568    3 LLKPTWVNHNGkPIFSVDIHPDGTKFATGGqgqDSGKVVIWNMSPvlqeddekdeniPKMLCQMDNHLACVNCVRWSNSG 82
Cdd:COG2319   111 LLLRTLTGHTG-AVRSVAFSPDGKTLASGS---ADGTVRLWDLAT------------GKLLRTLTGHSGAVTSVAFSPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   83 MYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNaVK 162
Cdd:COG2319   175 KLLASGSDDGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-LA 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  163 FPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRLSWSPDGHYLVSAha 242
Cdd:COG2319   235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSVAFSPDGKLLASG-- 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  243 mnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpscpycccAVGSKDRSLSVWLTCLKRPLVV 322
Cdd:COG2319   307 --SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKTL---------ASGSDDGTVRLWDLATGELLRT 367

                         330       340       350
                  ....*....|....*....|....*....|
gi 209364568  323 IHElFDKSIMDISWTLNGLGILVCSMDGSV 352
Cdd:COG2319   368 LTG-HTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-352 5.85e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.49  E-value: 5.85e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568    7 TWVNHNGkPIFSVDIHPDGTKFATGGQgqdSGKVVIWNMSPVLQEDDEKdenipkmlcqmdNHLACVNCVRWSNSGMYLA 86
Cdd:cd00200     4 TLKGHTG-GVTCVAFSPDGKLLATGSG---DGTIKVWDLETGELLRTLK------------GHTGPVRDVAASADGTYLA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   87 SGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFpEI 166
Cdd:cd00200    68 SGSSDKTIRLW-------------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KC 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  167 LATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSItkpfdecggTTH---VLRLSWSPDGHYLVSAham 243
Cdd:cd00200   128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---------TGHtgeVNSVAFSPDGEKLLSS--- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  244 nNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNP--KIFkkkqkngssakpscpycccAVGSKDRSLSVWLTCLKRPLV 321
Cdd:cd00200   196 -SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPdgYLL-------------------ASGSEDGTIRVWDLRTGECVQ 255

                         330       340       350
                  ....*....|....*....|....*....|.
gi 209364568  322 VIHElFDKSIMDISWTLNGLGILVCSMDGSV 352
Cdd:cd00200   256 TLSG-HTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-159 2.85e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 2.85e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 209364568    120 QWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWN 159
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
121-159 4.45e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 4.45e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 209364568   121 WRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWN 159
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 127-201 3.12e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  127 LRSHSGDVMDVAWSP-HDAWLASCSVDNTVVIW---------NAVKFPeiLATLRGHSGLVKGLTWDPVGKYI-ASQADD 195
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWeiphndesvKEIKDP--QCILKGHKKKISIIDWNPMNYYImCSSGFD 147


                  ....*.
gi 209364568  196 RSLKVW 201
Cdd:PTZ00420  148 SFVNIW 153
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 467-630 1.16e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  467 AQLDtGDFSTAFFNSIPLSSSLAGTMLSSPSGQQLLPLDSSTPSFGASK--PCTEPVAATSAR-PTGEPVSKDSMNATST 543
Cdd:PRK14950  335 SQLD-FQLRTTSYGQLPLELAVIEALLVPVPAPQPAKPTAAAPSPVRPTpaPSTRPKAAAAANiPPKEPVRETATPPPVP 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  544 PAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPSLTSVIP-----TAVERLKE--QNLVRELRSRE-----LDSS-- 609
Cdd:PRK14950  414 PRPVAPPVPHTPESAPKLTRAAIPVDEKPKYTPPAPPKEEEKAliadgDVLEQLEAiwKQILRDVPPRSpavqaLLSSgv 493

                         170       180
                  ....*....|....*....|....
gi 209364568  610 ---SDSDEKVHLAKPSSLSKRKLE 630
Cdd:PRK14950  494 rpvSVEKNTLTLSFKSKFHKDKIE 517
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 778-960 2.32e-58

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 199.77  E-value: 2.32e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   778 LHCTGPYVMALTAAATLSVWDVHRQVVVVKEESLHSILSGS---------DMTVSQILLTQHGIPVMNLSDGKAYCFNPS 848
Cdd:pfam07569   17 LECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGVPIVTLSNGDGYLYDKS 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   849 LSTWNLVSDKQDSLA-QCADFRNSLPSQDAMLCSGPLAIIQGRTSN--SGRQAARLFSVPHVV----------QQESTLA 915
Cdd:pfam07569   97 LETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLERKTNEelLRKGRGRLLQRLAKTllmkegfenfETVVTLA 176

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 209364568   916 YLESQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRLREICQDL 960
Cdd:pfam07569  177 HLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
3-352 6.57e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.92  E-value: 6.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568    3 LLKPTWVNHNGkPIFSVDIHPDGTKFATGGqgqDSGKVVIWNMSPvlqeddekdeniPKMLCQMDNHLACVNCVRWSNSG 82
Cdd:COG2319   111 LLLRTLTGHTG-AVRSVAFSPDGKTLASGS---ADGTVRLWDLAT------------GKLLRTLTGHSGAVTSVAFSPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   83 MYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNaVK 162
Cdd:COG2319   175 KLLASGSDDGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-LA 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  163 FPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRLSWSPDGHYLVSAha 242
Cdd:COG2319   235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSVAFSPDGKLLASG-- 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  243 mnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpscpycccAVGSKDRSLSVWLTCLKRPLVV 322
Cdd:COG2319   307 --SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKTL---------ASGSDDGTVRLWDLATGELLRT 367

                         330       340       350
                  ....*....|....*....|....*....|
gi 209364568  323 IHElFDKSIMDISWTLNGLGILVCSMDGSV 352
Cdd:COG2319   368 LTG-HTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-352 5.85e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.49  E-value: 5.85e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568    7 TWVNHNGkPIFSVDIHPDGTKFATGGQgqdSGKVVIWNMSPVLQEDDEKdenipkmlcqmdNHLACVNCVRWSNSGMYLA 86
Cdd:cd00200     4 TLKGHTG-GVTCVAFSPDGKLLATGSG---DGTIKVWDLETGELLRTLK------------GHTGPVRDVAASADGTYLA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   87 SGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFpEI 166
Cdd:cd00200    68 SGSSDKTIRLW-------------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KC 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  167 LATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSItkpfdecggTTH---VLRLSWSPDGHYLVSAham 243
Cdd:cd00200   128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---------TGHtgeVNSVAFSPDGEKLLSS--- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  244 nNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNP--KIFkkkqkngssakpscpycccAVGSKDRSLSVWLTCLKRPLV 321
Cdd:cd00200   196 -SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPdgYLL-------------------ASGSEDGTIRVWDLRTGECVQ 255

                         330       340       350
                  ....*....|....*....|....*....|.
gi 209364568  322 VIHElFDKSIMDISWTLNGLGILVCSMDGSV 352
Cdd:cd00200   256 TLSG-HTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
69-367 1.85e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 1.85e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   69 HLACVNCVRWSNSGMYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLAS 148
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLW-------------------DLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  149 CSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRL 228
Cdd:COG2319   138 GSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT------GHTGAVRSV 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  229 SWSPDGHYLVSAHAmnnsGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSAkpscpycccAVGSKDRS 308
Cdd:COG2319   211 AFSPDGKLLASGSA----DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--------DGRLL---------ASGSADGT 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 209364568  309 LSVWLTCLKRPLVVIHELFDkSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLS 367
Cdd:COG2319   270 VRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 69-356 3.76e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.07  E-value: 3.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   69 HLACVNCVRWSNSGMYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLAS 148
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW-------------------DLETGELLRTLKGHTGPVRDVAASADGTYLAS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  149 CSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRL 228
Cdd:cd00200    69 GSSDKTIRLWD-LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR------GHTDWVNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  229 SWSPDGHYLVSAHAMNnsgpTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSakpscpyccCAVGSKDRS 308
Cdd:cd00200   142 AFSPDGTFVASSSQDG----TIKLWDLRTGKCVATLTGHTGEVNSVAFSP--------DGEK---------LLSSSSDGT 200

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 209364568  309 LSVWLTCLKRPLVVIHElFDKSIMDISWTLNGLGILVCSMDGSVAFLD 356
Cdd:cd00200   201 IKLWDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
10-203 1.05e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 1.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   10 NHNGKPIFSVDIHPDGTKFATGGqgqDSGKVVIWNMSPvlqeddekdeniPKMLCQMDNHLACVNCVRWSNSGMYLASGG 89
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGS---ADGTVRLWDLAT------------GELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   90 DDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNaVKFPEILAT 169
Cdd:COG2319   308 DDGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD-LATGELLRT 367

                         170       180       190
                  ....*....|....*....|....*....|....
gi 209364568  170 LRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRT 203
Cdd:COG2319   368 LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-202 7.27e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 7.27e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568    7 TWVNHNgKPIFSVDIHPDGTKFATGGqgqDSGKVVIWNMSPvlqeddekdeniPKMLCQMDNHLACVNCVRWSNSGMYLA 86
Cdd:cd00200    88 TLTGHT-SYVSSVAFSPDGRILSSSS---RDKTIKVWDVET------------GKCLTTLRGHTDWVNSVAFSPDGTFVA 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568   87 SGGDDKLIMVW------KRATYIG-------------PSTVFGSSG----KLANVEQWRCVSILRSHSGDVMDVAWSPHD 143
Cdd:cd00200   152 SSSQDGTIKLWdlrtgkCVATLTGhtgevnsvafspdGEKLLSSSSdgtiKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 209364568  144 AWLASCSVDNTVVIWNAVKFpEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWR 202
Cdd:cd00200   232 YLLASGSEDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
106-367 5.16e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 5.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  106 STVFGSSGKLANVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPV 185
Cdd:COG2319    53 AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSPD 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  186 GKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRLSWSPDGHYLVSAHamnnSGPTAQIIEREGWKTNMDFV 265
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGKLLRTLT------GHSGAVTSVAFSPDGKLLASGS----DDGTVRLWDLATGKLLRTLT 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  266 GHRKAVTVVKFNPkifkkkqkNGSSAkpscpycccAVGSKDRSLSVW-LTclKRPLVVIHELFDKSIMDISWTLNGLGIL 344
Cdd:COG2319   202 GHTGAVRSVAFSP--------DGKLL---------ASGSADGTVRLWdLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                         250       260
                  ....*....|....*....|...
gi 209364568  345 VCSMDGSVAFLDFSQDELGDPLS 367
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLT 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-372 3.52e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.95  E-value: 3.52e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  123 CVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWr 202
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  203 tlDWQLETSITKPFDECGGtthVLRLSWSPDGHYLVSAHAMNnsgpTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifk 282
Cdd:cd00200    79 --DLETGECVRTLTGHTSY---VSSVAFSPDGRILSSSSRDK----TIKVWDVETGKCLTTLRGHTDWVNSVAFSP---- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  283 kkqkNGSSAkpscpycccAVGSKDRSLSVW-LTCLKrpLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDE 361
Cdd:cd00200   146 ----DGTFV---------ASSSQDGTIKLWdLRTGK--CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                         250
                  ....*....|.
gi 209364568  362 LGDPLSEEEKS 372
Cdd:cd00200   211 CLGTLRGHENG 221
WD40 COG2319
WD40 repeat [General function prediction only];
115-367 1.23e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 1.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  115 LANVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQAD 194
Cdd:COG2319    20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAFSPDGRLLASASA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  195 DRSLKVWRTLDWQLETSITkpfdecGGTTHVLRLSWSPDGHYLVSAHAmnnsGPTAQIIEREGWKTNMDFVGHRKAVTVV 274
Cdd:COG2319    99 DGTVRLWDLATGLLLRTLT------GHTGAVRSVAFSPDGKTLASGSA----DGTVRLWDLATGKLLRTLTGHSGAVTSV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  275 KFNPkifkkkqkNGSSAkpscpycccAVGSKDRSLSVWLTCLKRPLVVI--HelfDKSIMDISWTLNGLGILVCSMDGSV 352
Cdd:COG2319   169 AFSP--------DGKLL---------ASGSDDGTVRLWDLATGKLLRTLtgH---TGAVRSVAFSPDGKLLASGSADGTV 228

                         250
                  ....*....|....*
gi 209364568  353 AFLDFSQDELGDPLS 367
Cdd:COG2319   229 RLWDLATGKLLRTLT 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-159 2.85e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 2.85e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 209364568    120 QWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWN 159
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
121-159 4.45e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 4.45e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 209364568   121 WRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWN 159
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
7-101 6.12e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 6.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568    7 TWVNHNGkPIFSVDIHPDGTKFATGGqgqDSGKVVIWNMSPVLQeddekdenipkmLCQMDNHLACVNCVRWSNSGMYLA 86
Cdd:COG2319   325 TLTGHTG-AVRSVAFSPDGKTLASGS---DDGTVRLWDLATGEL------------LRTLTGHTGAVTSVAFSPDGRTLA 388

                          90
                  ....*....|....*
gi 209364568   87 SGGDDKLIMVWKRAT 101
Cdd:COG2319   389 SGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 61-98 3.18e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.18e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 209364568     61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWK 98
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 165-201 5.78e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 5.78e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 209364568    165 EILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 201
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
61-97 2.99e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.99e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 209364568    61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVW 97
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 127-201 3.12e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  127 LRSHSGDVMDVAWSP-HDAWLASCSVDNTVVIW---------NAVKFPeiLATLRGHSGLVKGLTWDPVGKYI-ASQADD 195
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWeiphndesvKEIKDP--QCILKGHKKKISIIDWNPMNYYImCSSGFD 147


                  ....*.
gi 209364568  196 RSLKVW 201
Cdd:PTZ00420  148 SFVNIW 153
WD40 pfam00400
WD domain, G-beta repeat;
165-201 4.30e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 4.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 209364568   165 EILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 201
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 129-245 1.05e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 46.57  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  129 SHSGDVMD--VAWSPHDAWLASCS-VDNTVVIW----NAVKFPEILATlrGHSGLVKGLTWDPVGKYIASQADDRSLKVw 201
Cdd:COG4946   338 TNTPGVRErlPAWSPDGKSIAYFSdASGEYELYiapaDGSGEPKQLTL--GDLGRVFNPVWSPDGKKIAFTDNRGRLWV- 414

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 209364568  202 rtLDwqLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNN 245
Cdd:COG4946   415 --VD--LASGKVRKVDTDGYGDGISDLAWSPDSKWLAYSKPGPN 454
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 467-630 1.16e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  467 AQLDtGDFSTAFFNSIPLSSSLAGTMLSSPSGQQLLPLDSSTPSFGASK--PCTEPVAATSAR-PTGEPVSKDSMNATST 543
Cdd:PRK14950  335 SQLD-FQLRTTSYGQLPLELAVIEALLVPVPAPQPAKPTAAAPSPVRPTpaPSTRPKAAAAANiPPKEPVRETATPPPVP 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364568  544 PAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPSLTSVIP-----TAVERLKE--QNLVRELRSRE-----LDSS-- 609
Cdd:PRK14950  414 PRPVAPPVPHTPESAPKLTRAAIPVDEKPKYTPPAPPKEEEKAliadgDVLEQLEAiwKQILRDVPPRSpavqaLLSSgv 493

                         170       180
                  ....*....|....*....|....
gi 209364568  610 ---SDSDEKVHLAKPSSLSKRKLE 630
Cdd:PRK14950  494 rpvSVEKNTLTLSFKSKFHKDKIE 517
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-44 8.21e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 8.21e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 209364568      7 TWVNHNGkPIFSVDIHPDGTKFATGGqgqDSGKVVIWN 44
Cdd:smart00320    7 TLKGHTG-PVTSVAFSPDGKYLASGS---DDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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