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Conserved domains on  [gi|212549690|ref|NP_001131131|]
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FRAS1-related extracellular matrix protein 3 precursor [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 55-256 2.20e-123

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


:

Pssm-ID: 466034  Cd Length: 202  Bit Score: 387.46  E-value: 2.20e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690    55 ILVANNGIRVPFGRSVYLDPINDLVTEVYAGDRCYITVLDNDPLAQRPGMLTPKKFPCAFGAEEVKYTHFGSRSPSKDHI 134
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDNDPLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   135 KLQLRYDSNTDTVVVPLILEVEVVFQQLEILTRNMPLVVDKLNGVSNPIDKKTLEFAFEDGVTTCKVTTLVGAGKLPRYG 214
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPGTERCKVTVLPGAGGLPRYG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 212549690   215 SLTDNSVNGQMINCDDFVKKGIQYQHTATTNSPNRDYIPMLV 256
Cdd:pfam19309  161 RLVNATGAPLMVDCEAFLRAGVRYQHTATTSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
1468-1575 6.97e-35

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 130.03  E-value: 6.97e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1468 NPVFRTFRVSITDVDNKKPVLTINK-LVLGEGEAKLITPFELTVEDRDTPDNLLRFIVTQVPVHGQILFNGT--QVITSF 1544
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 212549690  1545 TKQDLNENLITYKHDGTETNEDSFSFTVTDG 1575
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
390-496 3.26e-34

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 128.10  E-value: 3.26e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   390 SDPFAFMIVVKSMNTLAPVVTKNTGQLLFEGQSRPLSSsQNLEISDEDNL-DDVKITVVDGLKHGELSVLGS---QRKFF 465
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITP-DLLQAEDPDTPpEDLTYTVVQGPSHGHLALKGApglPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 212549690   466 TPADLDAGIVVYQHDGSDTYSDNIIFRMTDG 496
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1237-1353 1.18e-32

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 123.87  E-value: 1.18e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1237 HTVEEKVIIIVIPVDDETPRMAINDGLEVEIGETKVISNRVLKATDLDSEDKELTYIVRYGPGQGYLQRITKHGVVIgnv 1316
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPV--- 77

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 212549690  1317 stgMNFTQDELDKQLIQYVHTGQEGVRDLLKFDVTDG 1353
Cdd:pfam16184   78 ---TNFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1125-1235 1.92e-27

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 108.84  E-value: 1.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1125 SERHFFPIVIIPANDEKPEIFIRE-FVVMEGMSLVIDTPILNAADTDIPSDELVFEILKNPKHGdIVQQLSTGTVPVVKF 1203
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHG-HLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 212549690  1204 TLEQIkEASNIVYEHDDSETKEDSFEIRLTDG 1235
Cdd:pfam16184   81 TQADI-DSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
763-872 2.47e-26

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 105.76  E-value: 2.47e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   763 NSVDGLFTIFLQPVDNKPP-AITNTGFTVLERNTFIITKNELDASDQDTEDENIKFIVTQIPRFGQLQYLGIDMSNGETF 841
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPvLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 212549690   842 VLEDIENSRMAYIHSGEESLYDVIKLDISDG 872
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
874-989 1.05e-24

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 101.14  E-value: 1.05e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   874 HQVPIVVKISIKPVDDETPKIMLPAGLlgasiDVLENGATEITSNVIQGQDEDTDDLMLTFIVEEPPRLGEIMVNGAP-- 951
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGL-----RLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPgl 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 212549690   952 -AERFTQQDIINGVVVYVHTGGEigpiKEHDSFNLTISD 989
Cdd:pfam16184   76 pVTNFTQADIDSGLVVYVHDGSE----STSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
1358-1466 6.26e-24

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 98.83  E-value: 6.26e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1358 IDRYFYINIGSMDMVFPDV-INKGVTLKEGGKVTLTTDLLSTTDINSPDEYLSFSITRAPSRGHLESTDLPGVPISTFTQ 1436
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNFTQ 82

                           90       100       110
                   ....*....|....*....|....*....|
gi 212549690  1437 LQLAGNKIYYIHTsDDEVKMDSFEFEVTDG 1466
Cdd:pfam16184   83 ADIDSGLVVYVHD-GSESTSDGFTFQVTDG 111
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1723-1961 7.77e-21

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 101.02  E-value: 7.77e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1723 ISMEREYYIVDETAKFLEVTLKRRGY-LGETSFISIGTKDGTAKQDKDFRGkAQKQVQFNPGQTSATWKVKIFTDKEFET 1801
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGdLTNTVYVDYRTEDGTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1802 SEVFAIQLSEP---------------VMAVLEYPDKATVEIVDpDDESTVF-FPQAEYQIEEDIGELLVPVHRSGDVSQE 1865
Cdd:TIGR00845  481 DEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILD-DDHAGIFtFEEDVFHVSESIGIMEVKVLRTSGARGT 559

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1866 LMVLCYTHQGSATGttpstvlSYSDYitrpEDYTSILRFDKDEREKSCRIIIIDDSLYEKEETFNVSLSMPMGGQLGAKF 1945
Cdd:TIGR00845  560 VIVPYRTVEGTARG-------GGKDF----EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKA 628

                          250
                   ....*....|....*.
gi 212549690  1946 PSTKVVILADNDDEPS 1961
Cdd:TIGR00845  629 ALLLNETITDDDQKLT 644
Cadherin_3 super family cl28802
Cadherin-like;
500-628 2.34e-18

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 83.04  E-value: 2.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   500 VEFLFPITIAPTDDEPPIINANTGIVLFKNEVMQISPFILSATDIDSEDSTIKFILEEPFSAiGELLIKQVeppPDPSVW 579
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSH-GHLALKGA---PGLPVT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 212549690   580 KFSatdemfeqvvtewfQQDILDGKLFYRHKGPHSTttvTDQFVFRVQD 628
Cdd:pfam16184   79 NFT--------------QADIDSGLVVYVHDGSEST---SDGFTFQVTD 110
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2065-2295 2.59e-18

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 92.93  E-value: 2.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2065 PSKTVITINDTVTDLP-KVQFKEAEYKVAEGEGEVKAMVYRSG-DISQMSTVRCFTRQGSAQVMMDYDERpntdASTIVF 2142
Cdd:TIGR00845  384 VSMHEVATDDEENDPVsKIFFEPGHYTCLENCGTVALTVVRRGgDLTNTVYVDYRTEDGTANAGSDYEFT----EGTLVF 459

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2143 LPGEIEKPCIVTLVDDSIYEDHEEFRLVLGTPKSKSPYG----------ASIGEPKEALVTITDHKDKSIIRFSEIKYSV 2212
Cdd:TIGR00845  460 KPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGileanhvsavAQLASPNTATVTILDDDHAGIFTFEEDVFHV 539

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2213 IEpqrpgEIAVAKIPVLRLGDTSKVSVVRIHTKDGSAT-SGEDYNPLSQDVEFKEGETEHVVEIQVMYDGQREIREAFTV 2291
Cdd:TIGR00845  540 SE-----SIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFI 614


                   ....
gi 212549690  2292 HMKP 2295
Cdd:TIGR00845  615 ELGE 618
Cadherin_3 super family cl28802
Cadherin-like;
1593-1705 3.77e-17

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 79.57  E-value: 3.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1593 PQMMTIYINTVDNGVPQILVNKaapTLRVLHTGHlgFLITSKALKSADRDSPNKVLKYVITESPLHGFIMNSALGNDSIK 1672
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNT---GLRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 212549690  1673 SFSQADIDDMKICYVlLDGSNATSDIFYFTVED 1705
Cdd:pfam16184   79 NFTQADIDSGLVVYV-HDGSESTSDGFTFQVTD 110
Calx-beta super family cl02522
Calx-beta domain;
1960-2053 1.13e-15

Calx-beta domain;


The actual alignment was detected with superfamily member pfam03160:

Pssm-ID: 413355 [Multi-domain]  Cd Length: 91  Bit Score: 74.59  E-value: 1.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1960 PSFYFGETEYTVDESYGYVEVKVWRTGTDLSKTATVTVRsrrTDPVSAEAGLDYVGISRNLDFAPGVTMQTFRVTILDDL 2039
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYR---TEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|....
gi 212549690  2040 gqpELEGPETFELV 2053
Cdd:pfam03160   79 ---VYEGDENFFVL 89
Cadherin_3 super family cl28802
Cadherin-like;
1006-1121 1.27e-15

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 75.33  E-value: 1.27e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1006 VHVTILPVDSIPPVVNVGSQFVVVEGEKNVITLEHIQAEDTDTDDDDILCTIIIQSTSGYVENispapgseKSRAGTAIT 1085
Cdd:pfam16184    7 FNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLAL--------KGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 212549690  1086 AFTISDVGLGHIYYVqsiHKGVEPVEDRFTFRCSDG 1121
Cdd:pfam16184   79 NFTQADIDSGLVVYV---HDGSESTSDGFTFQVTDG 111
Cadherin_3 super family cl28802
Cadherin-like;
635-759 3.82e-13

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 68.01  E-value: 3.82e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   635 QSGEHVFTIKIHPVDDVPPELYPGTTLhmTVKEYELTFFKKKFLRYTDLDCDDRDLKYTITKPPtdtdeNHpvplGAIVL 714
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGL--RLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGP-----SH----GHLAL 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 212549690   715 TDSPDIIISEFTQAQINHHKVAYkppdQELGITPKVVQFSFSVED 759
Cdd:pfam16184   70 KGAPGLPVTNFTQADIDSGLVVY----VHDGSESTSDGFTFQVTD 110
Cadherin_3 super family cl28802
Cadherin-like;
303-387 2.16e-07

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 51.83  E-value: 2.16e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   303 MTAITSDMLAAEDIESKSDELIFNITSPLgyQQGFIISTDDQNQPITSFYQRDIKDLKIAYKPPSEDSDIERI-FQIefe 381
Cdd:pfam16184   34 SRPITPDLLQAEDPDTPPEDLTYTVVQGP--SHGHLALKGAPGLPVTNFTQADIDSGLVVYVHDGSESTSDGFtFQV--- 108


                   ....*.
gi 212549690   382 ivdTDG 387
Cdd:pfam16184  109 ---TDG 111
 
Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 55-256 2.20e-123

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


Pssm-ID: 466034  Cd Length: 202  Bit Score: 387.46  E-value: 2.20e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690    55 ILVANNGIRVPFGRSVYLDPINDLVTEVYAGDRCYITVLDNDPLAQRPGMLTPKKFPCAFGAEEVKYTHFGSRSPSKDHI 134
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDNDPLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   135 KLQLRYDSNTDTVVVPLILEVEVVFQQLEILTRNMPLVVDKLNGVSNPIDKKTLEFAFEDGVTTCKVTTLVGAGKLPRYG 214
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPGTERCKVTVLPGAGGLPRYG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 212549690   215 SLTDNSVNGQMINCDDFVKKGIQYQHTATTNSPNRDYIPMLV 256
Cdd:pfam19309  161 RLVNATGAPLMVDCEAFLRAGVRYQHTATTSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
1468-1575 6.97e-35

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 130.03  E-value: 6.97e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1468 NPVFRTFRVSITDVDNKKPVLTINK-LVLGEGEAKLITPFELTVEDRDTPDNLLRFIVTQVPVHGQILFNGT--QVITSF 1544
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 212549690  1545 TKQDLNENLITYKHDGTETNEDSFSFTVTDG 1575
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
390-496 3.26e-34

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 128.10  E-value: 3.26e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   390 SDPFAFMIVVKSMNTLAPVVTKNTGQLLFEGQSRPLSSsQNLEISDEDNL-DDVKITVVDGLKHGELSVLGS---QRKFF 465
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITP-DLLQAEDPDTPpEDLTYTVVQGPSHGHLALKGApglPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 212549690   466 TPADLDAGIVVYQHDGSDTYSDNIIFRMTDG 496
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1237-1353 1.18e-32

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 123.87  E-value: 1.18e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1237 HTVEEKVIIIVIPVDDETPRMAINDGLEVEIGETKVISNRVLKATDLDSEDKELTYIVRYGPGQGYLQRITKHGVVIgnv 1316
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPV--- 77

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 212549690  1317 stgMNFTQDELDKQLIQYVHTGQEGVRDLLKFDVTDG 1353
Cdd:pfam16184   78 ---TNFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1125-1235 1.92e-27

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 108.84  E-value: 1.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1125 SERHFFPIVIIPANDEKPEIFIRE-FVVMEGMSLVIDTPILNAADTDIPSDELVFEILKNPKHGdIVQQLSTGTVPVVKF 1203
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHG-HLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 212549690  1204 TLEQIkEASNIVYEHDDSETKEDSFEIRLTDG 1235
Cdd:pfam16184   81 TQADI-DSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
763-872 2.47e-26

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 105.76  E-value: 2.47e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   763 NSVDGLFTIFLQPVDNKPP-AITNTGFTVLERNTFIITKNELDASDQDTEDENIKFIVTQIPRFGQLQYLGIDMSNGETF 841
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPvLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 212549690   842 VLEDIENSRMAYIHSGEESLYDVIKLDISDG 872
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
874-989 1.05e-24

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 101.14  E-value: 1.05e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   874 HQVPIVVKISIKPVDDETPKIMLPAGLlgasiDVLENGATEITSNVIQGQDEDTDDLMLTFIVEEPPRLGEIMVNGAP-- 951
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGL-----RLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPgl 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 212549690   952 -AERFTQQDIINGVVVYVHTGGEigpiKEHDSFNLTISD 989
Cdd:pfam16184   76 pVTNFTQADIDSGLVVYVHDGSE----STSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
1358-1466 6.26e-24

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 98.83  E-value: 6.26e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1358 IDRYFYINIGSMDMVFPDV-INKGVTLKEGGKVTLTTDLLSTTDINSPDEYLSFSITRAPSRGHLESTDLPGVPISTFTQ 1436
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNFTQ 82

                           90       100       110
                   ....*....|....*....|....*....|
gi 212549690  1437 LQLAGNKIYYIHTsDDEVKMDSFEFEVTDG 1466
Cdd:pfam16184   83 ADIDSGLVVYVHD-GSESTSDGFTFQVTDG 111
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1723-1961 7.77e-21

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 101.02  E-value: 7.77e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1723 ISMEREYYIVDETAKFLEVTLKRRGY-LGETSFISIGTKDGTAKQDKDFRGkAQKQVQFNPGQTSATWKVKIFTDKEFET 1801
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGdLTNTVYVDYRTEDGTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1802 SEVFAIQLSEP---------------VMAVLEYPDKATVEIVDpDDESTVF-FPQAEYQIEEDIGELLVPVHRSGDVSQE 1865
Cdd:TIGR00845  481 DEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILD-DDHAGIFtFEEDVFHVSESIGIMEVKVLRTSGARGT 559

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1866 LMVLCYTHQGSATGttpstvlSYSDYitrpEDYTSILRFDKDEREKSCRIIIIDDSLYEKEETFNVSLSMPMGGQLGAKF 1945
Cdd:TIGR00845  560 VIVPYRTVEGTARG-------GGKDF----EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKA 628

                          250
                   ....*....|....*.
gi 212549690  1946 PSTKVVILADNDDEPS 1961
Cdd:TIGR00845  629 ALLLNETITDDDQKLT 644
Cadherin_3 pfam16184
Cadherin-like;
500-628 2.34e-18

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 83.04  E-value: 2.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   500 VEFLFPITIAPTDDEPPIINANTGIVLFKNEVMQISPFILSATDIDSEDSTIKFILEEPFSAiGELLIKQVeppPDPSVW 579
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSH-GHLALKGA---PGLPVT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 212549690   580 KFSatdemfeqvvtewfQQDILDGKLFYRHKGPHSTttvTDQFVFRVQD 628
Cdd:pfam16184   79 NFT--------------QADIDSGLVVYVHDGSEST---SDGFTFQVTD 110
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2065-2295 2.59e-18

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 92.93  E-value: 2.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2065 PSKTVITINDTVTDLP-KVQFKEAEYKVAEGEGEVKAMVYRSG-DISQMSTVRCFTRQGSAQVMMDYDERpntdASTIVF 2142
Cdd:TIGR00845  384 VSMHEVATDDEENDPVsKIFFEPGHYTCLENCGTVALTVVRRGgDLTNTVYVDYRTEDGTANAGSDYEFT----EGTLVF 459

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2143 LPGEIEKPCIVTLVDDSIYEDHEEFRLVLGTPKSKSPYG----------ASIGEPKEALVTITDHKDKSIIRFSEIKYSV 2212
Cdd:TIGR00845  460 KPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGileanhvsavAQLASPNTATVTILDDDHAGIFTFEEDVFHV 539

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2213 IEpqrpgEIAVAKIPVLRLGDTSKVSVVRIHTKDGSAT-SGEDYNPLSQDVEFKEGETEHVVEIQVMYDGQREIREAFTV 2291
Cdd:TIGR00845  540 SE-----SIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFI 614


                   ....
gi 212549690  2292 HMKP 2295
Cdd:TIGR00845  615 ELGE 618
Cadherin_3 pfam16184
Cadherin-like;
1593-1705 3.77e-17

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 79.57  E-value: 3.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1593 PQMMTIYINTVDNGVPQILVNKaapTLRVLHTGHlgFLITSKALKSADRDSPNKVLKYVITESPLHGFIMNSALGNDSIK 1672
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNT---GLRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 212549690  1673 SFSQADIDDMKICYVlLDGSNATSDIFYFTVED 1705
Cdd:pfam16184   79 NFTQADIDSGLVVYV-HDGSESTSDGFTFQVTD 110
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1954-2175 3.57e-16

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 85.61  E-value: 3.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1954 ADNDDEPSFYFGETEYTVDESYGYVEVKVWRTGTDLSKTATVtvrSRRTDPVSAEAGLDYVGISRNLDFAPGVTMQTFRV 2033
Cdd:TIGR00845  394 EENDPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYV---DYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRI 470

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2034 TILDD------------LGQPELEGPETFELVMRMPMNAVLGEPSKTVITINDtvTDLPKV-QFKEAEYKVAEGEGEVKA 2100
Cdd:TIGR00845  471 GIIDDdifeedehfyvrLSNLRVGSEDGILEANHVSAVAQLASPNTATVTILD--DDHAGIfTFEEDVFHVSESIGIMEV 548

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549690  2101 MVYRSGDISQMSTVRCFTRQGSAQvmmdYDERPNTDA-STIVFLPGEIEKPCIVTLVDDSIYEDHEEFRLVLGTPK 2175
Cdd:TIGR00845  549 KVLRTSGARGTVIVPYRTVEGTAR----GGGKDFEDTcGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPR 620
Calx-beta pfam03160
Calx-beta domain;
1960-2053 1.13e-15

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 74.59  E-value: 1.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1960 PSFYFGETEYTVDESYGYVEVKVWRTGTDLSKTATVTVRsrrTDPVSAEAGLDYVGISRNLDFAPGVTMQTFRVTILDDL 2039
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYR---TEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|....
gi 212549690  2040 gqpELEGPETFELV 2053
Cdd:pfam03160   79 ---VYEGDENFFVL 89
Cadherin_3 pfam16184
Cadherin-like;
1006-1121 1.27e-15

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 75.33  E-value: 1.27e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1006 VHVTILPVDSIPPVVNVGSQFVVVEGEKNVITLEHIQAEDTDTDDDDILCTIIIQSTSGYVENispapgseKSRAGTAIT 1085
Cdd:pfam16184    7 FNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLAL--------KGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 212549690  1086 AFTISDVGLGHIYYVqsiHKGVEPVEDRFTFRCSDG 1121
Cdd:pfam16184   79 NFTQADIDSGLVVYV---HDGSESTSDGFTFQVTDG 111
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1961-2050 2.99e-14

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 70.36  E-value: 2.99e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   1961 SFYFGETEYTVDESYGYVEVKVWRTGtDLSKTATVTVRsrrTDPVSAEAGLDYVGISRNLDFAPGVTMQTFRVTILDDlg 2040
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTG-GARGPVVVPYS---TEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD-- 76

                            90
                    ....*....|
gi 212549690   2041 qPELEGPETF 2050
Cdd:smart00237   77 -DIYEKDETF 85
Cadherin_3 pfam16184
Cadherin-like;
635-759 3.82e-13

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 68.01  E-value: 3.82e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   635 QSGEHVFTIKIHPVDDVPPELYPGTTLhmTVKEYELTFFKKKFLRYTDLDCDDRDLKYTITKPPtdtdeNHpvplGAIVL 714
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGL--RLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGP-----SH----GHLAL 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 212549690   715 TDSPDIIISEFTQAQINHHKVAYkppdQELGITPKVVQFSFSVED 759
Cdd:pfam16184   70 KGAPGLPVTNFTQADIDSGLVVY----VHDGSESTSDGFTFQVTD 110
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1723-1810 1.28e-11

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 63.04  E-value: 1.28e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   1723 ISMEREYYIVDETAKFLEVTLKRRGYLGETSFISIGTKDGTAKQDKDFRGKAQkQVQFNPGQTSATWKVKIFTDKEFETS 1802
Cdd:smart00237    4 VGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPG-ELTFPPGETEKEIRIKIIDDDIYEKD 82


                    ....*...
gi 212549690   1803 EVFAIQLS 1810
Cdd:smart00237   83 ETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
1834-1934 1.85e-11

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 62.65  E-value: 1.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1834 STVFFPQAEYQIEEDIGELLVPVHR-SGDVSQELMVLCYTHQGSATGttpstvlsysdyitrPEDYTSI---LRFDKDER 1909
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRmSGTLRRTVVVPYRTEDGTATA---------------GDDYEPVegeLVFGPGET 66

                           90       100
                   ....*....|....*....|....*
gi 212549690  1910 EKSCRIIIIDDSLYEKEETFNVSLS 1934
Cdd:pfam03160   67 EKCINVTIIDDDVYEGDENFFVLLS 91
Calx-beta pfam03160
Calx-beta domain;
2080-2172 2.92e-11

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 61.88  E-value: 2.92e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2080 PKVQFKEAEYKVAEGEGEVKAMVYR-SGDISQMSTVRCFTRQGSAQVMMDYderPNTDAsTIVFLPGEIEKPCIVTLVDD 2158
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRmSGTLRRTVVVPYRTEDGTATAGDDY---EPVEG-ELVFGPGETEKCINVTIIDD 77

                           90
                   ....*....|....
gi 212549690  2159 SIYEDHEEFRLVLG 2172
Cdd:pfam03160   78 DVYEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2081-2172 6.73e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 58.03  E-value: 6.73e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   2081 KVQFKEAEYKVAEGEGEVKAMVYRSGDISQMSTVRCFTRQGSAQVMMDYDERPntdaSTIVFLPGEIEKpCI-VTLVDDS 2159
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVP----GELTFPPGETEK-EIrIKIIDDD 77

                            90
                    ....*....|...
gi 212549690   2160 IYEDHEEFRLVLG 2172
Cdd:smart00237   78 IYEKDETFYVRLS 90
Cadherin_3 pfam16184
Cadherin-like;
303-387 2.16e-07

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 51.83  E-value: 2.16e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   303 MTAITSDMLAAEDIESKSDELIFNITSPLgyQQGFIISTDDQNQPITSFYQRDIKDLKIAYKPPSEDSDIERI-FQIefe 381
Cdd:pfam16184   34 SRPITPDLLQAEDPDTPPEDLTYTVVQGP--SHGHLALKGAPGLPVTNFTQADIDSGLVVYVHDGSESTSDGFtFQV--- 108


                   ....*.
gi 212549690   382 ivdTDG 387
Cdd:pfam16184  109 ---TDG 111
 
Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 55-256 2.20e-123

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


Pssm-ID: 466034  Cd Length: 202  Bit Score: 387.46  E-value: 2.20e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690    55 ILVANNGIRVPFGRSVYLDPINDLVTEVYAGDRCYITVLDNDPLAQRPGMLTPKKFPCAFGAEEVKYTHFGSRSPSKDHI 134
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDNDPLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   135 KLQLRYDSNTDTVVVPLILEVEVVFQQLEILTRNMPLVVDKLNGVSNPIDKKTLEFAFEDGVTTCKVTTLVGAGKLPRYG 214
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPGTERCKVTVLPGAGGLPRYG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 212549690   215 SLTDNSVNGQMINCDDFVKKGIQYQHTATTNSPNRDYIPMLV 256
Cdd:pfam19309  161 RLVNATGAPLMVDCEAFLRAGVRYQHTATTSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
1468-1575 6.97e-35

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 130.03  E-value: 6.97e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1468 NPVFRTFRVSITDVDNKKPVLTINK-LVLGEGEAKLITPFELTVEDRDTPDNLLRFIVTQVPVHGQILFNGT--QVITSF 1544
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 212549690  1545 TKQDLNENLITYKHDGTETNEDSFSFTVTDG 1575
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
390-496 3.26e-34

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 128.10  E-value: 3.26e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   390 SDPFAFMIVVKSMNTLAPVVTKNTGQLLFEGQSRPLSSsQNLEISDEDNL-DDVKITVVDGLKHGELSVLGS---QRKFF 465
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITP-DLLQAEDPDTPpEDLTYTVVQGPSHGHLALKGApglPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 212549690   466 TPADLDAGIVVYQHDGSDTYSDNIIFRMTDG 496
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1237-1353 1.18e-32

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 123.87  E-value: 1.18e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1237 HTVEEKVIIIVIPVDDETPRMAINDGLEVEIGETKVISNRVLKATDLDSEDKELTYIVRYGPGQGYLQRITKHGVVIgnv 1316
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPV--- 77

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 212549690  1317 stgMNFTQDELDKQLIQYVHTGQEGVRDLLKFDVTDG 1353
Cdd:pfam16184   78 ---TNFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1125-1235 1.92e-27

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 108.84  E-value: 1.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1125 SERHFFPIVIIPANDEKPEIFIRE-FVVMEGMSLVIDTPILNAADTDIPSDELVFEILKNPKHGdIVQQLSTGTVPVVKF 1203
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHG-HLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 212549690  1204 TLEQIkEASNIVYEHDDSETKEDSFEIRLTDG 1235
Cdd:pfam16184   81 TQADI-DSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
763-872 2.47e-26

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 105.76  E-value: 2.47e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   763 NSVDGLFTIFLQPVDNKPP-AITNTGFTVLERNTFIITKNELDASDQDTEDENIKFIVTQIPRFGQLQYLGIDMSNGETF 841
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPvLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 212549690   842 VLEDIENSRMAYIHSGEESLYDVIKLDISDG 872
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
874-989 1.05e-24

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 101.14  E-value: 1.05e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   874 HQVPIVVKISIKPVDDETPKIMLPAGLlgasiDVLENGATEITSNVIQGQDEDTDDLMLTFIVEEPPRLGEIMVNGAP-- 951
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGL-----RLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPgl 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 212549690   952 -AERFTQQDIINGVVVYVHTGGEigpiKEHDSFNLTISD 989
Cdd:pfam16184   76 pVTNFTQADIDSGLVVYVHDGSE----STSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
1358-1466 6.26e-24

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 98.83  E-value: 6.26e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1358 IDRYFYINIGSMDMVFPDV-INKGVTLKEGGKVTLTTDLLSTTDINSPDEYLSFSITRAPSRGHLESTDLPGVPISTFTQ 1436
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNFTQ 82

                           90       100       110
                   ....*....|....*....|....*....|
gi 212549690  1437 LQLAGNKIYYIHTsDDEVKMDSFEFEVTDG 1466
Cdd:pfam16184   83 ADIDSGLVVYVHD-GSESTSDGFTFQVTDG 111
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1723-1961 7.77e-21

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 101.02  E-value: 7.77e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1723 ISMEREYYIVDETAKFLEVTLKRRGY-LGETSFISIGTKDGTAKQDKDFRGkAQKQVQFNPGQTSATWKVKIFTDKEFET 1801
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGdLTNTVYVDYRTEDGTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1802 SEVFAIQLSEP---------------VMAVLEYPDKATVEIVDpDDESTVF-FPQAEYQIEEDIGELLVPVHRSGDVSQE 1865
Cdd:TIGR00845  481 DEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILD-DDHAGIFtFEEDVFHVSESIGIMEVKVLRTSGARGT 559

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1866 LMVLCYTHQGSATGttpstvlSYSDYitrpEDYTSILRFDKDEREKSCRIIIIDDSLYEKEETFNVSLSMPMGGQLGAKF 1945
Cdd:TIGR00845  560 VIVPYRTVEGTARG-------GGKDF----EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKA 628

                          250
                   ....*....|....*.
gi 212549690  1946 PSTKVVILADNDDEPS 1961
Cdd:TIGR00845  629 ALLLNETITDDDQKLT 644
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1826-2093 4.41e-19

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 95.24  E-value: 4.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1826 EIVDPDDESTVFFPQAEYQIEEDIGELLVPVHRSG-DVSQELMVLCYTHQGSATGTtpstvlsySDYITRpedyTSILRF 1904
Cdd:TIGR00845  392 DDEENDPVSKIFFEPGHYTCLENCGTVALTVVRRGgDLTNTVYVDYRTEDGTANAG--------SDYEFT----EGTLVF 459

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1905 DKDEREKSCRIIIIDDSLYEKEETFNVSLSMPMGG---------------QLGAkfPSTKVVILADNDDEPSFYFGETEY 1969
Cdd:TIGR00845  460 KPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGsedgileanhvsavaQLAS--PNTATVTILDDDHAGIFTFEEDVF 537

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1970 TVDESYGYVEVKVWRTGtdlSKTATVTVRSRRTDPVSAEAGLDYVGISRNLDFAPGVTMQTFRVTILDDlgqPELEGPET 2049
Cdd:TIGR00845  538 HVSESIGIMEVKVLRTS---GARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDD---EEYEKNDT 611

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 212549690  2050 FELVMRMPMNAVLGEPSKTVITINDTVTDLPKVQFKEAEYKVAE 2093
Cdd:TIGR00845  612 FFIELGEPRWAKRGIKAALLLNETITDDDQKLTSKEEEERRIAE 655
Cadherin_3 pfam16184
Cadherin-like;
500-628 2.34e-18

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 83.04  E-value: 2.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   500 VEFLFPITIAPTDDEPPIINANTGIVLFKNEVMQISPFILSATDIDSEDSTIKFILEEPFSAiGELLIKQVeppPDPSVW 579
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSH-GHLALKGA---PGLPVT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 212549690   580 KFSatdemfeqvvtewfQQDILDGKLFYRHKGPHSTttvTDQFVFRVQD 628
Cdd:pfam16184   79 NFT--------------QADIDSGLVVYVHDGSEST---SDGFTFQVTD 110
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2065-2295 2.59e-18

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 92.93  E-value: 2.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2065 PSKTVITINDTVTDLP-KVQFKEAEYKVAEGEGEVKAMVYRSG-DISQMSTVRCFTRQGSAQVMMDYDERpntdASTIVF 2142
Cdd:TIGR00845  384 VSMHEVATDDEENDPVsKIFFEPGHYTCLENCGTVALTVVRRGgDLTNTVYVDYRTEDGTANAGSDYEFT----EGTLVF 459

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2143 LPGEIEKPCIVTLVDDSIYEDHEEFRLVLGTPKSKSPYG----------ASIGEPKEALVTITDHKDKSIIRFSEIKYSV 2212
Cdd:TIGR00845  460 KPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGileanhvsavAQLASPNTATVTILDDDHAGIFTFEEDVFHV 539

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2213 IEpqrpgEIAVAKIPVLRLGDTSKVSVVRIHTKDGSAT-SGEDYNPLSQDVEFKEGETEHVVEIQVMYDGQREIREAFTV 2291
Cdd:TIGR00845  540 SE-----SIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFI 614


                   ....
gi 212549690  2292 HMKP 2295
Cdd:TIGR00845  615 ELGE 618
Cadherin_3 pfam16184
Cadherin-like;
1593-1705 3.77e-17

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 79.57  E-value: 3.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1593 PQMMTIYINTVDNGVPQILVNKaapTLRVLHTGHlgFLITSKALKSADRDSPNKVLKYVITESPLHGFIMNSALGNDSIK 1672
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNT---GLRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 212549690  1673 SFSQADIDDMKICYVlLDGSNATSDIFYFTVED 1705
Cdd:pfam16184   79 NFTQADIDSGLVVYV-HDGSESTSDGFTFQVTD 110
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1954-2175 3.57e-16

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 85.61  E-value: 3.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1954 ADNDDEPSFYFGETEYTVDESYGYVEVKVWRTGTDLSKTATVtvrSRRTDPVSAEAGLDYVGISRNLDFAPGVTMQTFRV 2033
Cdd:TIGR00845  394 EENDPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYV---DYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRI 470

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2034 TILDD------------LGQPELEGPETFELVMRMPMNAVLGEPSKTVITINDtvTDLPKV-QFKEAEYKVAEGEGEVKA 2100
Cdd:TIGR00845  471 GIIDDdifeedehfyvrLSNLRVGSEDGILEANHVSAVAQLASPNTATVTILD--DDHAGIfTFEEDVFHVSESIGIMEV 548

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549690  2101 MVYRSGDISQMSTVRCFTRQGSAQvmmdYDERPNTDA-STIVFLPGEIEKPCIVTLVDDSIYEDHEEFRLVLGTPK 2175
Cdd:TIGR00845  549 KVLRTSGARGTVIVPYRTVEGTAR----GGGKDFEDTcGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPR 620
Calx-beta pfam03160
Calx-beta domain;
1960-2053 1.13e-15

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 74.59  E-value: 1.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1960 PSFYFGETEYTVDESYGYVEVKVWRTGTDLSKTATVTVRsrrTDPVSAEAGLDYVGISRNLDFAPGVTMQTFRVTILDDL 2039
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYR---TEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|....
gi 212549690  2040 gqpELEGPETFELV 2053
Cdd:pfam03160   79 ---VYEGDENFFVL 89
Cadherin_3 pfam16184
Cadherin-like;
1006-1121 1.27e-15

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 75.33  E-value: 1.27e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1006 VHVTILPVDSIPPVVNVGSQFVVVEGEKNVITLEHIQAEDTDTDDDDILCTIIIQSTSGYVENispapgseKSRAGTAIT 1085
Cdd:pfam16184    7 FNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLAL--------KGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 212549690  1086 AFTISDVGLGHIYYVqsiHKGVEPVEDRFTFRCSDG 1121
Cdd:pfam16184   79 NFTQADIDSGLVVYV---HDGSESTSDGFTFQVTDG 111
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1961-2050 2.99e-14

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 70.36  E-value: 2.99e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   1961 SFYFGETEYTVDESYGYVEVKVWRTGtDLSKTATVTVRsrrTDPVSAEAGLDYVGISRNLDFAPGVTMQTFRVTILDDlg 2040
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTG-GARGPVVVPYS---TEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD-- 76

                            90
                    ....*....|
gi 212549690   2041 qPELEGPETF 2050
Cdd:smart00237   77 -DIYEKDETF 85
Cadherin_3 pfam16184
Cadherin-like;
635-759 3.82e-13

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 68.01  E-value: 3.82e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   635 QSGEHVFTIKIHPVDDVPPELYPGTTLhmTVKEYELTFFKKKFLRYTDLDCDDRDLKYTITKPPtdtdeNHpvplGAIVL 714
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGL--RLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGP-----SH----GHLAL 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 212549690   715 TDSPDIIISEFTQAQINHHKVAYkppdQELGITPKVVQFSFSVED 759
Cdd:pfam16184   70 KGAPGLPVTNFTQADIDSGLVVY----VHDGSESTSDGFTFQVTD 110
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1723-1810 1.28e-11

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 63.04  E-value: 1.28e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   1723 ISMEREYYIVDETAKFLEVTLKRRGYLGETSFISIGTKDGTAKQDKDFRGKAQkQVQFNPGQTSATWKVKIFTDKEFETS 1802
Cdd:smart00237    4 VGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPG-ELTFPPGETEKEIRIKIIDDDIYEKD 82


                    ....*...
gi 212549690   1803 EVFAIQLS 1810
Cdd:smart00237   83 ETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
1834-1934 1.85e-11

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 62.65  E-value: 1.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1834 STVFFPQAEYQIEEDIGELLVPVHR-SGDVSQELMVLCYTHQGSATGttpstvlsysdyitrPEDYTSI---LRFDKDER 1909
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRmSGTLRRTVVVPYRTEDGTATA---------------GDDYEPVegeLVFGPGET 66

                           90       100
                   ....*....|....*....|....*
gi 212549690  1910 EKSCRIIIIDDSLYEKEETFNVSLS 1934
Cdd:pfam03160   67 EKCINVTIIDDDVYEGDENFFVLLS 91
Calx-beta pfam03160
Calx-beta domain;
2080-2172 2.92e-11

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 61.88  E-value: 2.92e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2080 PKVQFKEAEYKVAEGEGEVKAMVYR-SGDISQMSTVRCFTRQGSAQVMMDYderPNTDAsTIVFLPGEIEKPCIVTLVDD 2158
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRmSGTLRRTVVVPYRTEDGTATAGDDY---EPVEG-ELVFGPGETEKCINVTIIDD 77

                           90
                   ....*....|....
gi 212549690  2159 SIYEDHEEFRLVLG 2172
Cdd:pfam03160   78 DVYEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1834-1934 9.96e-11

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 60.35  E-value: 9.96e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   1834 STVFFPQAEYQIEEDIGELLVPVHRSGDVSQELMVLCYTHQGSATGTtpstvlsySDYItrPEDYTsiLRFDKDEREKSC 1913
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG--------SDYE--PVPGE--LTFPPGETEKEI 69

                            90       100
                    ....*....|....*....|.
gi 212549690   1914 RIIIIDDSLYEKEETFNVSLS 1934
Cdd:smart00237   70 RIKIIDDDIYEKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
2201-2292 1.71e-10

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 59.96  E-value: 1.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  2201 SIIRFSEIKYSVIEpqrpgEIAVAKIPVLRL-GDTSKVSVVRIHTKDGSATSGEDYNPLSQDVEFKEGETEHVVEIQVMY 2279
Cdd:pfam03160    2 GVIGFEPPTYQVSE-----NDGVAEVCVVRMsGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID 76

                           90
                   ....*....|...
gi 212549690  2280 DGQREIREAFTVH 2292
Cdd:pfam03160   77 DDVYEGDENFFVL 89
Calx-beta pfam03160
Calx-beta domain;
1723-1810 3.91e-10

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 58.80  E-value: 3.91e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690  1723 ISMEREYYIVDETAKFLEVTLKRR-GYLGETSFISIGTKDGTAKQDKDFRGKAQkQVQFNPGQTSATWKVKIFTDKEFET 1801
Cdd:pfam03160    4 IGFEPPTYQVSENDGVAEVCVVRMsGTLRRTVVVPYRTEDGTATAGDDYEPVEG-ELVFGPGETEKCINVTIIDDDVYEG 82


                   ....*....
gi 212549690  1802 SEVFAIQLS 1810
Cdd:pfam03160   83 DENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2081-2172 6.73e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 58.03  E-value: 6.73e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   2081 KVQFKEAEYKVAEGEGEVKAMVYRSGDISQMSTVRCFTRQGSAQVMMDYDERPntdaSTIVFLPGEIEKpCI-VTLVDDS 2159
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVP----GELTFPPGETEK-EIrIKIIDDD 77

                            90
                    ....*....|...
gi 212549690   2160 IYEDHEEFRLVLG 2172
Cdd:smart00237   78 IYEKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2201-2292 1.62e-09

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 56.88  E-value: 1.62e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   2201 SIIRFSEIKYSVIEpqrpgEIAVAKIPVLRLGDTSKVSVVRIHTKDGSATSGEDYNPLSQDVEFKEGETEHVVEIQVMYD 2280
Cdd:smart00237    2 GSVGFEQPVYTVSE-----SDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD 76

                            90
                    ....*....|..
gi 212549690   2281 GQREIREAFTVH 2292
Cdd:smart00237   77 DIYEKDETFYVR 88
Cadherin_3 pfam16184
Cadherin-like;
303-387 2.16e-07

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 51.83  E-value: 2.16e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549690   303 MTAITSDMLAAEDIESKSDELIFNITSPLgyQQGFIISTDDQNQPITSFYQRDIKDLKIAYKPPSEDSDIERI-FQIefe 381
Cdd:pfam16184   34 SRPITPDLLQAEDPDTPPEDLTYTVVQGP--SHGHLALKGAPGLPVTNFTQADIDSGLVVYVHDGSESTSDGFtFQV--- 108


                   ....*.
gi 212549690   382 ivdTDG 387
Cdd:pfam16184  109 ---TDG 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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