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Conserved domains on  [gi|215272341|ref|NP_001135822|]
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THO complex subunit 6 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-256 2.61e-20

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 2.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341   7 LAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSM-VST 85
Cdd:COG2319   61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----------ATGLLLRTLTGHTGAVRSVaFSP 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341  86 D-RHLLSAG-DGEVKAWlwaemlkkgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRV 163
Cdd:COG2319  131 DgKTLASGSaDGTVRLW-----------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 164 LRGHTDYIHCLALrerSPE---VLSGGEDGAVRLWDLRTAKEVQTIEvykheecsrpHNGRWIGCLA--TDSDWMVCGGG 238
Cdd:COG2319  200 LTGHTGAVRSVAF---SPDgklLASGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAfsPDGRLLASGSA 266

                        250
                 ....*....|....*....
gi 215272341 239 -PALTLWHLRSSTPTTIFP 256
Cdd:COG2319  267 dGTVRLWDLATGELLRTLT 285
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-256 2.61e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 2.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341   7 LAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSM-VST 85
Cdd:COG2319   61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----------ATGLLLRTLTGHTGAVRSVaFSP 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341  86 D-RHLLSAG-DGEVKAWlwaemlkkgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRV 163
Cdd:COG2319  131 DgKTLASGSaDGTVRLW-----------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 164 LRGHTDYIHCLALrerSPE---VLSGGEDGAVRLWDLRTAKEVQTIEvykheecsrpHNGRWIGCLA--TDSDWMVCGGG 238
Cdd:COG2319  200 LTGHTGAVRSVAF---SPDgklLASGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAfsPDGRLLASGSA 266

                        250
                 ....*....|....*....
gi 215272341 239 -PALTLWHLRSSTPTTIFP 256
Cdd:COG2319  267 dGTVRLWDLATGELLRTLT 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-265 4.09e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 4.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341  31 SVSPCGKFLAAGNNYGQIAIFslssalsseaKEESKKPVVTFQAHDGPVYSM-VSTDRHLLSAGDGEVKAWLWaEMLKKG 109
Cdd:cd00200   58 AASADGTYLASGSSDKTIRLW----------DLETGECVRTLTGHTSYVSSVaFSPDGRILSSSSRDKTIKVW-DVETGK 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 110 CKelwrrqppyrTSLEVPE--INALLLVPkeNSLILAGG--DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLS 185
Cdd:cd00200  127 CL----------TTLRGHTdwVNSVAFSP--DGTFVASSsqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 186 GGEDGAVRLWDLRTAKEVQTIEVykHEEcsrphngrWIGCLATDSD-WMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHV 264
Cdd:cd00200  195 SSSDGTIKLWDLSTGKCLGTLRG--HEN--------GVNSVAFSPDgYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSV 264


                 .
gi 215272341 265 T 265
Cdd:cd00200  265 T 265
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 2.41e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.41e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 215272341   157 TGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 2.14e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 2.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 215272341  158 GTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-256 2.61e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 2.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341   7 LAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSM-VST 85
Cdd:COG2319   61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----------ATGLLLRTLTGHTGAVRSVaFSP 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341  86 D-RHLLSAG-DGEVKAWlwaemlkkgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRV 163
Cdd:COG2319  131 DgKTLASGSaDGTVRLW-----------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 164 LRGHTDYIHCLALrerSPE---VLSGGEDGAVRLWDLRTAKEVQTIEvykheecsrpHNGRWIGCLA--TDSDWMVCGGG 238
Cdd:COG2319  200 LTGHTGAVRSVAF---SPDgklLASGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAfsPDGRLLASGSA 266

                        250
                 ....*....|....*....
gi 215272341 239 -PALTLWHLRSSTPTTIFP 256
Cdd:COG2319  267 dGTVRLWDLATGELLRTLT 285
WD40 COG2319
WD40 repeat [General function prediction only];
31-248 3.30e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 3.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341  31 SVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSMV-STD-RHLLSAG-DGEVKAWlwaemlk 107
Cdd:COG2319  211 AFSPDGKLLASGSADGTVRLWDL----------ATGKLLRTLTGHSGSVRSVAfSPDgRLLASGSaDGTVRLW------- 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 108 kgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGG 187
Cdd:COG2319  274 ----DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272341 188 EDGAVRLWDLRTAKEVQTIevykheecsRPHNGrWIGCLA--TDSDWMVCGGGP-ALTLWHLRS 248
Cdd:COG2319  350 DDGTVRLWDLATGELLRTL---------TGHTG-AVTSVAfsPDGRTLASGSADgTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-265 4.09e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 4.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341  31 SVSPCGKFLAAGNNYGQIAIFslssalsseaKEESKKPVVTFQAHDGPVYSM-VSTDRHLLSAGDGEVKAWLWaEMLKKG 109
Cdd:cd00200   58 AASADGTYLASGSSDKTIRLW----------DLETGECVRTLTGHTSYVSSVaFSPDGRILSSSSRDKTIKVW-DVETGK 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 110 CKelwrrqppyrTSLEVPE--INALLLVPkeNSLILAGG--DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLS 185
Cdd:cd00200  127 CL----------TTLRGHTdwVNSVAFSP--DGTFVASSsqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 186 GGEDGAVRLWDLRTAKEVQTIEVykHEEcsrphngrWIGCLATDSD-WMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHV 264
Cdd:cd00200  195 SSSDGTIKLWDLSTGKCLGTLRG--HEN--------GVNSVAFSPDgYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSV 264


                 .
gi 215272341 265 T 265
Cdd:cd00200  265 T 265
WD40 COG2319
WD40 repeat [General function prediction only];
70-256 3.52e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 3.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341  70 VTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAemlkkgckeLWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQ 149
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLD---------AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 150 LHTMDLETGTFTRVLRGHTDYIHCLALrerSPE---VLSGGEDGAVRLWDLRTAKEVQTIevykheecsRPHNGrWIGCL 226
Cdd:COG2319  102 VRLWDLATGLLLRTLTGHTGAVRSVAF---SPDgktLASGSADGTVRLWDLATGKLLRTL---------TGHSG-AVTSV 168

                        170       180       190
                 ....*....|....*....|....*....|...
gi 215272341 227 A--TDSDWMVCGGG-PALTLWHLRSSTPTTIFP 256
Cdd:COG2319  169 AfsPDGKLLASGSDdGTVRLWDLATGKLLRTLT 201
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 27-248 4.33e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 4.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341  27 IFSQSVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSMVSTDRH--LLSAG-DGEVKAWLWa 103
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDL----------ETGELLRTLKGHTGPVRDVAASADGtyLASGSsDKTIRLWDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 104 emlkKGCKELWRrqppYRTSLEvpEINALLLVPKeNSLILAGG-DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPE 182
Cdd:cd00200   81 ----ETGECVRT----LTGHTS--YVSSVAFSPD-GRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215272341 183 VLSGGEDGAVRLWDLRTAKEVQTIEvykheecsrPHNGrWIGCLATDSDW---MVCGGGPALTLWHLRS 248
Cdd:cd00200  150 VASSSQDGTIKLWDLRTGKCVATLT---------GHTG-EVNSVAFSPDGeklLSSSSDGTIKLWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-196 5.87e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 5.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341  31 SVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSM-VSTD--RHLLSAGDGEVKAWlwaEMLK 107
Cdd:cd00200  142 AFSPDGTFVASSSQDGTIKLWDL----------RTGKCVATLTGHTGEVNSVaFSPDgeKLLSSSSDGTIKLW---DLST 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 108 KGCKELWRRQPPYrtslevpeINALLLVPkeNSLILAGGDCQLHTM--DLETGTFTRVLRGHTDYIHCLALRERSPEVLS 185
Cdd:cd00200  209 GKCLGTLRGHENG--------VNSVAFSP--DGYLLASGSEDGTIRvwDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278

                        170
                 ....*....|.
gi 215272341 186 GGEDGAVRLWD 196
Cdd:cd00200  279 GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 161-286 1.40e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341 161 TRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVykHEecsrpHNGRWIGCLAtDSDWMVCGGGP- 239
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG--HT-----GPVRDVAASA-DGTYLASGSSDk 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272341 240 ALTLWHLRSSTPTTIF-----PIRApqkhVTFYQDL-VLTAAG--NSCRV-DVFTN 286
Cdd:cd00200   74 TIRLWDLETGECVRTLtghtsYVSS----VAFSPDGrILSSSSrdKTIKVwDVETG 125
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 2.41e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.41e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 215272341   157 TGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 2.14e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 2.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 215272341  158 GTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
15-100 7.28e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 7.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272341  15 EVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSMV-STD-RHLLSA 92
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL----------ATGELLRTLTGHTGAVTSVAfSPDgRTLASG 390


                 ....*....
gi 215272341  93 G-DGEVKAW 100
Cdd:COG2319  391 SaDGTVRLW 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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