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Conserved domains on  [gi|215490098|ref|NP_001135921|]
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protein spinster homolog 1 isoform 4 [Homo sapiens]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0006869
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1.49

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 62-405 3.52e-151

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 435.51  E-value: 3.52e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  62 VAVLCYINLLNYMDRFTVA----------------------VFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLG 119
Cdd:cd17328    1 VAVLFLINLLNYMDRFTIAgvlpdiqsdfliddslagllqtVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 120 SSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALR 199
Cdd:cd17328   81 SSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 200 VTPGLGVVAVLLLFLVVREPPRGAVERHsDLPPLNPTSWWADLRALARN------------------------------- 248
Cdd:cd17328  159 VTGVLGVLLAILLLLFVREPPRGAAEGG-VMAKSTATSFLADLKALAKNpsfilstlgftavsfvtgalafwaptfflra 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 249 ------------LIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFI 316
Cdd:cd17328  238 fgvgdlssadvgLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 317 GETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNwPPSFLSEFRALQFSLMLCAFV 396
Cdd:cd17328  318 GEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFV 396


                 ....*....
gi 215490098 397 GALGGAAFL 405
Cdd:cd17328  397 LVLGGFFFL 405
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 62-405 3.52e-151

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 435.51  E-value: 3.52e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  62 VAVLCYINLLNYMDRFTVA----------------------VFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLG 119
Cdd:cd17328    1 VAVLFLINLLNYMDRFTIAgvlpdiqsdfliddslagllqtVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 120 SSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALR 199
Cdd:cd17328   81 SSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 200 VTPGLGVVAVLLLFLVVREPPRGAVERHsDLPPLNPTSWWADLRALARN------------------------------- 248
Cdd:cd17328  159 VTGVLGVLLAILLLLFVREPPRGAAEGG-VMAKSTATSFLADLKALAKNpsfilstlgftavsfvtgalafwaptfflra 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 249 ------------LIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFI 316
Cdd:cd17328  238 fgvgdlssadvgLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 317 GETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNwPPSFLSEFRALQFSLMLCAFV 396
Cdd:cd17328  318 GEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFV 396


                 ....*....
gi 215490098 397 GALGGAAFL 405
Cdd:cd17328  397 LVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
60-405 4.95e-21

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 94.17  E-value: 4.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  60 LIVAVLCYINLLNYMDRFTVAVFIS----------------------SYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVT 117
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPplqadlglsaaqlgllasafflGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 118 LGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 197
Cdd:COG2271   90 LLFGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 198 LRVT------PGLGVVAVLLLFLVVREPPRGAVERHSdlpplnpTSWWADLR--ALARNLIFGLITCLTGVLGVGLGVEI 269
Cdd:COG2271  167 FLILglpgllLALLRFWLLALAYFLVYFALYGFLTWL-------PTYLVEVRglSLAQAGLLLSLPFLAGIVGSLLGGWL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 270 SRRLRhsnpRADPLVCATGLLGSAPFLFLSLACarGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFqI 349
Cdd:COG2271  240 SDRLG----RRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-V 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215490098 350 VLSHLLGDAGSPYLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGALGGAAFL 405
Cdd:COG2271  313 NTFGFLGGALGPLLVGYLLDAT-------------GYQAAFLLLAALALLAALLAL 355
MFS_1 pfam07690
Major Facilitator Superfamily;
79-337 2.63e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 73.99  E-value: 2.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098   79 VAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFV 158
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS--LWLLLVLRVLQGLGAGALFPAALALIADWFP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  159 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSW 238
Cdd:pfam07690 116 PEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  239 WADLRALARNLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCA-TGLLGSAPFLFLSLACARGSIVATYIFIFIG 317
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGlGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274

                         250       260
                  ....*....|....*....|
gi 215490098  318 ETLLSMNWAIVADILLYVVI 337
Cdd:pfam07690 275 LILAALGLLLLSLTLSSLWL 294
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 77-221 5.47e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 51.61  E-value: 5.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098   77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:TIGR00881  34 LLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST--SLWVMAALWALNGIFQGMGWPPCGRTVTKW 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215490098  157 FVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVREPPR 221
Cdd:TIGR00881 112 FSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQ 176
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 62-405 3.52e-151

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 435.51  E-value: 3.52e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  62 VAVLCYINLLNYMDRFTVA----------------------VFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLG 119
Cdd:cd17328    1 VAVLFLINLLNYMDRFTIAgvlpdiqsdfliddslagllqtVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 120 SSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALR 199
Cdd:cd17328   81 SSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 200 VTPGLGVVAVLLLFLVVREPPRGAVERHsDLPPLNPTSWWADLRALARN------------------------------- 248
Cdd:cd17328  159 VTGVLGVLLAILLLLFVREPPRGAAEGG-VMAKSTATSFLADLKALAKNpsfilstlgftavsfvtgalafwaptfflra 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 249 ------------LIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFI 316
Cdd:cd17328  238 fgvgdlssadvgLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 317 GETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNwPPSFLSEFRALQFSLMLCAFV 396
Cdd:cd17328  318 GEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFV 396


                 ....*....
gi 215490098 397 GALGGAAFL 405
Cdd:cd17328  397 LVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
60-405 4.95e-21

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 94.17  E-value: 4.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  60 LIVAVLCYINLLNYMDRFTVAVFIS----------------------SYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVT 117
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPplqadlglsaaqlgllasafflGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 118 LGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 197
Cdd:COG2271   90 LLFGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 198 LRVT------PGLGVVAVLLLFLVVREPPRGAVERHSdlpplnpTSWWADLR--ALARNLIFGLITCLTGVLGVGLGVEI 269
Cdd:COG2271  167 FLILglpgllLALLRFWLLALAYFLVYFALYGFLTWL-------PTYLVEVRglSLAQAGLLLSLPFLAGIVGSLLGGWL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 270 SRRLRhsnpRADPLVCATGLLGSAPFLFLSLACarGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFqI 349
Cdd:COG2271  240 SDRLG----RRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-V 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215490098 350 VLSHLLGDAGSPYLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGALGGAAFL 405
Cdd:COG2271  313 NTFGFLGGALGPLLVGYLLDAT-------------GYQAAFLLLAALALLAALLAL 355
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 79-405 1.79e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 83.63  E-value: 1.79e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  79 VAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFV 158
Cdd:cd06174   37 FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS--FWLLLLGRFLLGLGSGLIDPAVLALIADLFP 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 159 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG-DWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSdlpPLNPTS 237
Cdd:cd06174  115 ERERGRALGLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNE---EASSKS 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 238 WWADLRALARN---------------------------------------LIFGLITCLTGVLGVGLGVEISRRLRhsnP 278
Cdd:cd06174  192 VLKLLKRVLKNpglwllllaiflvnlayysfstllplflldlgglsvavaGLLLSLFGLAGALGSLLLGLLSDRLI---G 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 279 RADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADIllyvVIPTRRSTAEAFQIVLSHLLGDA 358
Cdd:cd06174  269 RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL----FPPEIRGTAFGLLNTFGFLGGAI 344

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 215490098 359 GSPYLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGALGGAAFL 405
Cdd:cd06174  345 GPLLAGFLLAATF-------------GLTGAFLVLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
77-267 4.31e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 76.17  E-value: 4.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:COG2814   49 LVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 157 FVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLLLFLVVREPprgaverhsdlPPLNPT 236
Cdd:COG2814  127 VPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLVNAVLALLALLLLLRLLPES-----------RPAARA 194

                        170       180       190
                 ....*....|....*....|....*....|.
gi 215490098 237 SWWADLRALARNLIFGLITCLTGVLGVGLGV 267
Cdd:COG2814  195 RLRGSLRELLRRPRLLLLLLLAFLLGFGFFA 225
MFS_1 pfam07690
Major Facilitator Superfamily;
79-337 2.63e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 73.99  E-value: 2.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098   79 VAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFV 158
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS--LWLLLVLRVLQGLGAGALFPAALALIADWFP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  159 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSW 238
Cdd:pfam07690 116 PEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  239 WADLRALARNLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCA-TGLLGSAPFLFLSLACARGSIVATYIFIFIG 317
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGlGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274

                         250       260
                  ....*....|....*....|
gi 215490098  318 ETLLSMNWAIVADILLYVVI 337
Cdd:pfam07690 275 LILAALGLLLLSLTLSSLWL 294
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 77-184 1.03e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 72.22  E-value: 1.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:cd17325   35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT--SYWQLLLARFLQGLASAAVWPAAMALIADI 112

                         90       100
                 ....*....|....*....|....*...
gi 215490098 157 FVADQRSRMLSIFYFAIPVGSGLGYIAG 184
Cdd:cd17325  113 APPEERGRAMGIFSSAIGLGFLIGPLLG 140
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 77-317 5.79e-12

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 66.37  E-value: 5.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:COG0477   53 WIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS--PELLIAARALQGIGAGGLMPGALALIAEL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 157 FVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW-----ALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLP 231
Cdd:COG0477  131 FPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG-WRWiflinAPLGLLALVLRLRLPESRGLLLALLALALAALLLA 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 232 PLNPTSWWADLRALARNLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATY 311
Cdd:COG0477  210 ALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLL 289


                 ....*.
gi 215490098 312 IFIFIG 317
Cdd:COG0477  290 LLALLL 295
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 60-197 1.45e-11

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 65.67  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  60 LIVAVLCYINLLNYMDRFTVAV----------------------FISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVT 117
Cdd:cd17319    3 RIIPLLFLAYVINYLDRVNISVaaptimkdlglsptqygliasaFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 118 LGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 197
Cdd:cd17319   83 ALTGFATS--LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG-WRWA 159
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 87-177 2.75e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 64.90  E-value: 2.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  87 MVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRML 166
Cdd:cd17473   49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS--LYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKML 126

                         90
                 ....*....|.
gi 215490098 167 SIFYFAIPVGS 177
Cdd:cd17473  127 GLQSAAMSLGG 137
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 62-196 3.88e-10

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 61.03  E-value: 3.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  62 VAVLCYINLLNYMDRFTVAVFI------------SSYMVLAPVF----------GYLGDRYNRKYLMCGGIAFWSLVTLG 119
Cdd:cd17380    1 VILLFLATCICYADRVNMPIAIvpmakefgwsktDQGLVLSSFFwgyaltqvlgGYLADRFGGKKVLLLAVALWSLATLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215490098 120 SSFIPGEHFWLLLLTRGLVGVGEA-SYSTIApTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 196
Cdd:cd17380   81 TPLLAYSSLPLLILSRILLGLGEGvHFPSMT-SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPS 156
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 92-198 1.29e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 59.54  E-value: 1.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  92 VFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYF 171
Cdd:cd17316   55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPT--PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQS 132

                         90       100       110
                 ....*....|....*....|....*....|
gi 215490098 172 AIPVGSGLGYIAGSKVKDMAGD---WHWAL 198
Cdd:cd17316  133 GWALGALLAALVASLLIPLLSGdwgWRILF 162
Sugar_tr pfam00083
Sugar (and other) transporter;
81-196 2.05e-09

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 59.21  E-value: 2.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098   81 VFISSYMVLAPV----FGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPG-EHFWLLLLTRGLVGVGEASYSTIAPTLIAD 155
Cdd:pfam00083  50 LIVSIFSVGCFIgslfAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGkWSVYQLIVGRVLVGIGVGGASVLAPMYISE 129

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 215490098  156 LFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHW 196
Cdd:pfam00083 130 IAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGW 170
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 77-192 4.90e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 57.97  E-value: 4.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:cd17325  239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGLGLGLVFPATLALLADI 316

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 215490098 157 FVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG 192
Cdd:cd17325  317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 75-196 9.31e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 56.81  E-value: 9.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  75 DRFTVAVFISSYM----VLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAP 150
Cdd:cd17474   32 SPAQVGLLITAFTlpaaVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS--FALLLAGRALQGIGAAGLGPLAL 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 215490098 151 TLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSkvkdMAGDWHW 196
Cdd:cd17474  110 TLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG----LLAAISW 151
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
77-200 3.01e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 55.66  E-value: 3.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:COG2223   44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS--YWLLLLLGLLLGIGGGGSFAVGIALVSKW 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 215490098 157 FVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRV 200
Cdd:COG2223  122 FPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-WRNAFLI 164
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
80-192 4.32e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 55.29  E-value: 4.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  80 AVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVA 159
Cdd:COG2211  271 ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDY 350

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 215490098 160 DQ-------RSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG 192
Cdd:COG2211  351 DEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 77-405 5.41e-08

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 54.48  E-value: 5.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSymVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:cd17478   37 VSVFSITSS--LLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN--YWLLLLLVALAGIGSAAFHPEGARLASQA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 157 FvADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVvrePPRGAVERHSDLPPLNPT 236
Cdd:cd17478  113 A-GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR---PLKKPEAKKAAAKSSARS 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 237 SWWADLRALArnLIFGLITC----------------------------------LTGVLGVGLGVEISRRLRHSNpradp 282
Cdd:cd17478  189 TLKGVWRALL--LLLIIVFLrswvlsslttflpfylvqrgyslvfaglllslflFAGAIGTLIGGPLSDRFGRRR----- 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 283 lVCATGLLGSAPFLFLSLACargSIVATYIFIFIGETLLSMNWAIvadILLYV--VIPTRRSTAEAFQIVLSHLLGDAGS 360
Cdd:cd17478  262 -VIIASLLLAAPFLLLFLLT---PGIWSYILLVLAGFLLFASFPV---TVVLAqeLLPGNVGLASGLMMGLSFGLGGIGA 334

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 215490098 361 PyLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGALGGAAFL 405
Cdd:cd17478  335 P-VLGALADAF-------------GLESVLLILALLPLLGALLAF 365
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 77-201 1.16e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 53.35  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:cd17317   29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 215490098 157 FVADQRSRMLSIFYFAIPVG----SGLGYIagskvkdmAGDWHWALRVT 201
Cdd:cd17317  107 VGPKYRSFVGILFGLFWALGymllALLAYL--------IRDWRWLQLAI 147
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 78-185 1.52e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 53.32  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  78 TVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGssFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLF 157
Cdd:cd17370  239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLG--FALGSSLWLLLLGFILWGLYMGAQESIERAAVADLV 316

                         90       100
                 ....*....|....*....|....*...
gi 215490098 158 VADQRSRMLSIFYFaipvGSGLGYIAGS 185
Cdd:cd17370  317 PAELRGTAYGLFNT----VVGIGWLLAS 340
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 78-196 1.62e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 52.95  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  78 TVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLF 157
Cdd:cd17321   36 VVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--LAFLIAARALQGIGAAAIMPASLALIAATF 113

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 215490098 158 VADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 196
Cdd:cd17321  114 PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRW 151
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 77-221 5.47e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 51.61  E-value: 5.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098   77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:TIGR00881  34 LLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST--SLWVMAALWALNGIFQGMGWPPCGRTVTKW 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215490098  157 FVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVREPPR 221
Cdd:TIGR00881 112 FSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQ 176
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 78-196 1.23e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 50.27  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  78 TVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLF 157
Cdd:cd17323   39 GVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP--NIAMLIILRFLQGFFGSSPLAIGAGTIADLF 116

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 215490098 158 VADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDmAGDWHW 196
Cdd:cd17323  117 TPEERGKAMGVYSLGPLLGPALGPIIGGFITQ-SLGWRW 154
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 87-198 1.61e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.89  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  87 MVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRML 166
Cdd:cd17365   48 AIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAV 125

                         90       100       110
                 ....*....|....*....|....*....|..
gi 215490098 167 SIFYFAIPVGSGLGYIAGSKVKDMAGdWHWAL 198
Cdd:cd17365  126 TLMFCGYPLGAALGGFLAAALIPAFG-WRSVF 156
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 77-409 1.90e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.86  E-value: 1.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:cd17324   38 LLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS--FALLLLARALAGLAHGGFWAIAAAYAADL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 157 FVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLLLFLVVREPPRgaverHSDLPPLNPT 236
Cdd:cd17324  116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLALLAALLLWRLLPSLPP-----KKPGSLGLLS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 237 SWWADLRALARNLIFGLITCLTGVLGVG---LGVEISRRLRHSNPRADPLvcatgllgsapFLFLSLACARGSIVATYIF 313
Cdd:cd17324  190 SLLLLLRNPRLRLAYLITFLLFGGFFALytyLAPFLTDVPGFSSSAIIGL-----------LLLFGVAGVVGSPLAGRLA 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 314 -IFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLShLLGDAGSPYLIGLISDRLRRNwppsflsefRALQFSLML 392
Cdd:cd17324  259 dRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWG-LGFFAAHSALQTRVLRLAPEA---------RGLASSLYL 328

                        330
                 ....*....|....*...
gi 215490098 393 CAF-VGALGGAAFLGTAI 409
Cdd:cd17324  329 AAYnLGGALGAALGGLVL 346
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 81-197 2.15e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 49.50  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  81 VFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYsTIAPTLIADLFVAD 160
Cdd:cd17504   39 AYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAP--NLPVLIAGRALQGIGGAVF-PLAFALVREEFPPE 115

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 215490098 161 QRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 197
Cdd:cd17504  116 RVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-WRWI 151
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 75-196 3.33e-06

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 49.24  E-value: 3.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098   75 DRFTVAVFISSYMV----LAPVFGYLGDRYNRKYLMcggiaFWS-LVTLGSSFIPG--EHFWLLLLTRGLVGVGEASYST 147
Cdd:TIGR00898 125 DAWKVDLTQSCFFVgvllGSFVFGYLSDRFGRKKVL-----LLStLVTAVSGVLTAfsPNYTVFLVFRLLVGMGIGGIWV 199

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 215490098  148 IAPTLIADLFVADQRsRMLSIFYFaipVGSGLGYIAGSKVKDMAGDWHW 196
Cdd:TIGR00898 200 QAVVLNTEFLPKKQR-AIVGTLIQ---VFFSLGLVLLPLVAYFIPDWRW 244
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 90-198 3.97e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 48.72  E-value: 3.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  90 APVFGYLGDRYNR-KYLMCGGIAFwSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSI 168
Cdd:cd17359   53 ALFAGRLADRFGRrKTLLISAVLF-FISALGSAFSP--NFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSL 129

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 215490098 169 FYFAIPVGSGLGYIAGSKVKDMAGD-------WHWAL 198
Cdd:cd17359  130 NQLMIVFGQLLAYIVNYLIANAGGAdwlgaegWRWML 166
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
80-179 5.90e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.05  E-value: 5.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  80 AVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVA 159
Cdd:COG2814  250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327

                         90       100
                 ....*....|....*....|
gi 215490098 160 DQRSRMLSIFYFAIPVGSGL 179
Cdd:COG2814  328 EARGRASGLYNSAFFLGGPL 347
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 70-197 9.84e-06

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 47.57  E-value: 9.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  70 LLNYMDRFTVAVFISSY--MV-LAPVF-GYLGDRY--NRKYLMCGGIafwsLVTLG--SSFIPGEHFWLLLLTRGLVGVG 141
Cdd:cd17346   33 LGDGFSEADAASIYGAYtaLVyLTPIIgGWLADKVlgARRTVFIGGI----LMALGylLLALSPFSVSMLYLGLALIIVG 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215490098 142 EASYSTIAPTLIADLFVADQ--RSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 197
Cdd:cd17346  109 NGLFKPNISSLVGKLYDENDprRDSGFSIFYMGINLGAFLAPLLCGTLGDNYG-YHYG 165
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 88-185 1.15e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.22  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  88 VLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIpgEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLS 167
Cdd:cd17329   50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA--HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFS 127

                         90
                 ....*....|....*...
gi 215490098 168 IFYFAIPVGSGLGYIAGS 185
Cdd:cd17329  128 LLYWAINLGVAIGPLLGG 145
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 77-168 1.38e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 47.19  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:cd17320   38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS--SIEQLLIARFLQGLGAAAGSVVARAIVRDL 115

                         90
                 ....*....|..
gi 215490098 157 FVADQRSRMLSI 168
Cdd:cd17320  116 YSGAELAKIFSL 127
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 86-180 1.70e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 46.83  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  86 YMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRM 165
Cdd:cd17316  226 ALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATG 305

                         90
                 ....*....|....*
gi 215490098 166 LSIFYFAIPVGSGLG 180
Cdd:cd17316  306 VGLSYNLGRLGGGGA 320
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 83-196 2.20e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 46.40  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  83 ISSYM----VLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFV 158
Cdd:cd17502   36 GTAYLltstAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN--MTMLIVGRAIQGIGGGGLMSLAFIIIADLVP 113

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 215490098 159 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 196
Cdd:cd17502  114 PRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS-WRW 150
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 81-194 3.98e-05

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 45.71  E-value: 3.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  81 VFISSY----MVLAPVFGYLGDRYNR-KYLMCGGIafwsLVTLGS--SFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLI 153
Cdd:cd17403   43 LIASSYdiasVLLLLFVSYFGGRGHKpRWLGIGAF----IMGIGSlvFALP--HFTVFILAQLLHGAGATPLYTLGVTYL 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 215490098 154 aDLFVADQRSRM-LSIFYFAIPVGSGLGYIAGSKVKDMAGDW 194
Cdd:cd17403  117 -DENVSTKMSPLyIGIFYAMAILGPAIGYVLGGFLLNLYTDI 157
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
85-200 8.23e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.84  E-value: 8.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  85 SYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFvADQRSR 164
Cdd:COG0738   55 GYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--YPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAAS 131

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 215490098 165 MLSIFYFAIPVGSGLGYIAGSKV--KDMAGDWHWALRV 200
Cdd:COG0738  132 RLNLLHAFFSLGALLGPLLGGLLilLGLSLSWHLPYLI 169
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
86-261 1.08e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.48  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  86 YMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFvADQRSRM 165
Cdd:COG2807   66 FGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPS--VALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLM 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 166 LSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPplnPTSWWADLRAL 245
Cdd:COG2807  143 TGLYTAAMGLGAALAAGLTVPLAAALG-WRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAS---LRSLWRSPLAW 218

                        170
                 ....*....|....*.
gi 215490098 246 ARNLIFGLITCLTGVL 261
Cdd:COG2807  219 LLTLFFGLQSLLYYAV 234
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
87-198 1.15e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  87 MVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRML 166
Cdd:COG2223  255 ALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG-SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVY 333

                         90       100       110
                 ....*....|....*....|....*....|..
gi 215490098 167 SIFYFAIPVGSGLGYIAGSKVKDMAGDWHWAL 198
Cdd:COG2223  334 GLVGAAGGLGGFLGPLLFGALLDATGSYTAAF 365
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 78-196 1.40e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 44.10  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  78 TVAVFISSYM----VLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLI 153
Cdd:cd17503   32 TVQWVITSYLlalaIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAP--NLASLIIFRILQGFGGGVLIPLAQTIL 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 215490098 154 ADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 196
Cdd:cd17503  110 LRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLS-WRW 151
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 78-201 2.38e-04

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 43.26  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  78 TVAVFISsYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgEHFWLLLLtRGLVGVGEASYSTiAPTLIADLF 157
Cdd:cd17442   42 TTMVFFG-YMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAP-SYIWFVFL-RCMVGCGVSGHSQ-GLIIKTEFL 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 215490098 158 VADQRSRML---SIFYFAipvGSGLGYIAGSKVKDMAGdWHWALRVT 201
Cdd:cd17442  118 PTKYRGYMLplsQIFWLA---GSLLIIGLASVVIPTLG-WRWLIRFA 160
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 81-192 2.60e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.97  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  81 VFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVAD 160
Cdd:cd17489  235 VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGS--PWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312

                         90       100       110
                 ....*....|....*....|....*....|..
gi 215490098 161 QRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG 192
Cdd:cd17489  313 RRGAANGTFFIFFDLGIGLGGLLLGLVAELFG 344
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 61-180 2.81e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 43.01  E-value: 2.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  61 IVAVLCYINLLNYMDRFTVA-----------------------VFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVT 117
Cdd:cd17327    6 ILPLLCILYFLQYLDKSNISnaavmgmkedlklvgnqynwgntVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLT 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215490098 118 LGSSFIpgEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLG 180
Cdd:cd17327   86 LLTAAV--KNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG 146
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 94-182 2.97e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 43.01  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  94 GYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEhFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAI 173
Cdd:cd17356   66 SFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGK-WYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAI 144


                 ....*....
gi 215490098 174 PVGSGLGYI 182
Cdd:cd17356  145 TIGILVAYC 153
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 94-194 5.45e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 42.18  E-value: 5.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  94 GYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAI 173
Cdd:cd17315   55 GPLADRFGRRKSLLIAAVLYVIGALLSALAPN--VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMI 132

                         90       100
                 ....*....|....*....|.
gi 215490098 174 PVGSGLGYIAGSKVKDMAGDW 194
Cdd:cd17315  133 TFGILLAYLLGLALSLSPPGW 153
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 77-202 5.65e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 41.88  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFipGEHFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:cd17312   42 IIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGF--STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNW 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 215490098 157 FVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDmAGDWHWALRVTP 202
Cdd:cd17312  120 FSKKERGTVYGIWSTSHNFGGILAPILAASLAS-YYGWRAAFLVPG 164
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 78-203 7.49e-04

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 41.80  E-value: 7.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098   78 TVAVFISSY----MVLAPVFGYLGDRYNR-KYLMCGGIafwsLVTLGS--SFIPgeHFWLLLLTRGLVGVGEASYSTIAP 150
Cdd:pfam03137  37 LSGLISSSYdignLLLIVFVSYFGGKGHRpRWIGVGAL----LMGLGSllFALP--HFLSFFLGQLLLGIGGTPIYTLGI 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 215490098  151 TLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWH-WALRVTPG 203
Cdd:pfam03137 111 SYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGkVSITLTPK 164
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 92-196 8.67e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 41.57  E-value: 8.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  92 VFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYF 171
Cdd:cd17362   58 VAGALIDRLGRRKELILAALLYLVGSLVTGLAPS--YPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKEL 135

                         90       100
                 ....*....|....*....|....*
gi 215490098 172 AIPVGSGLGYIAGSKVKDMAGDWHW 196
Cdd:cd17362  136 FIVLGILLGYVSGYAFADVVGGWRY 160
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 93-179 1.33e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 40.75  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  93 FGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFA 172
Cdd:cd17371   54 GGILADRFGRVRVLVITILLFAVFTLLCGFAQN--YWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSG 131


                 ....*..
gi 215490098 173 IPVGSGL 179
Cdd:cd17371  132 WAVGWLL 138
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 77-337 1.52e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.66  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADL 156
Cdd:cd17489   35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--VALLLVLRLIHGIGWGAFTTAAATLVADI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 157 FVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdwHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPP---- 232
Cdd:cd17489  113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRafrr 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098 233 -LNPTSWWADLRALARNLIFGLITCLTGVLGVGLGveisrrlrHSNPRADPLVCATGLLGSAPFlFLSLACARG---SIV 308
Cdd:cd17489  191 lVEKKVLPPALILFLASIAYGAISTFLPLYAAERG--------ISNAGLFFTVYAIALLLSRPF-SGKLSDRKGpktVII 261

                        250       260
                 ....*....|....*....|....*....
gi 215490098 309 ATYIFIFIGETLLSMNWAIVADILLYVVI 337
Cdd:cd17489  262 PGLLLLALGLLLLSFAGSPWMLLLAAVLY 290
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 79-198 1.79e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 40.33  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  79 VAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFV 158
Cdd:cd17360   41 VSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAP--NKEVLIVGRVLVGLGVGIASMTVPLYIAEAAP 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 215490098 159 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWAL 198
Cdd:cd17360  119 PRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWML 158
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 87-185 2.01e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 40.25  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  87 MVLAPVFGYLGDRYNRKYLM----CGGIAFWSLVTLGSSFipgehfWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQR 162
Cdd:cd17358   55 LIGALLSGKLADRIGRKRTLlisaIPCILGWLLIAFAKDV------WMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVR 128

                         90       100
                 ....*....|....*....|...
gi 215490098 163 SRMLSIFYFAIPVGSGLGYIAGS 185
Cdd:cd17358  129 GALGSLNQLLVNIGILLGYVLGS 151
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 88-228 2.11e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 40.30  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  88 VLAPVFGYLGDRYNRKYLMCGGIAFW---SLVTLGSSFIPGehfwlLLLTRGLVGVGeASYSTIAPTLIADLFVADQRSR 164
Cdd:cd06179   47 VLGPIVGRLSDLFGRRWFFIGGNLLGvvgSIVAGTAKSVNM-----LIGGQALIGIG-AGTQGLGAAVASELVPNKYRGL 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215490098 165 MLSIFYFAIPVGSGLG-YIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHS 228
Cdd:cd06179  121 VQGVVNLVASPGSALGpLIAGALVEANAAGWRWIFYINAIFNALALILLFFFYHPPPRPQLHGSS 185
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 63-201 2.23e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 40.21  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  63 AVLCYINLLNYMDRFTVAVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgEHFWLLLLtRGLVGVGE 142
Cdd:cd17372   24 AVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAP-NYMWLIIL-RCLVGLGL 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215490098 143 ASYSTIApTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVT 201
Cdd:cd17372  102 GGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG-WRWLLAFS 158
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 92-197 2.36e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 39.94  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  92 VFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFwlLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRM-LSIFY 170
Cdd:cd17476   52 IFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIF--FIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIvFSLFG 129

                         90       100
                 ....*....|....*....|....*..
gi 215490098 171 FAIPVGSGLGYIAGSKVKDMAGdWHWA 197
Cdd:cd17476  130 ATAPLGFALGGVFGGLFAQLAW-WPWI 155
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 86-183 2.67e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 39.91  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  86 YMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLgssFIP---GEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQR 162
Cdd:cd17318   69 YILTQIPGGYLAEKYGAKRVLGYSILITALLTL---LTPlaaRGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLER 145

                         90       100
                 ....*....|....*....|....*.
gi 215490098 163 SRMLSIFYFAIPVGSGL-----GYIA 183
Cdd:cd17318  146 SRLTSIAYSGSQFGTVIamplsGFLC 171
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 87-184 2.86e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 39.65  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098   87 MVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFipGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRML 166
Cdd:TIGR00895  66 AFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCAL--ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAV 143

                          90
                  ....*....|....*....
gi 215490098  167 SIFYFAIPVG-SGLGYIAG 184
Cdd:TIGR00895 144 GLMFCGYPIGaAVGGFLAG 162
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
 77-179 3.58e-03

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 39.52  E-value: 3.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISsymvlaPVFG-YLGDRYNRKYLMCGGIAF-----WSLVTLGSSFIPG-EHFWLLLLTRGLVGVGEASYSTIA 149
Cdd:cd17347   47 FVMLCYFF------PLLGaIIADSYLGKYRTILYLSLvyclgHIVLAVTAIPPLGpPHVWGLLIGLLLIAIGTGGIKPCV 120

                         90       100       110
                 ....*....|....*....|....*....|...
gi 215490098 150 PTLIADLFVADQ---RSRMLSIFYFAIPVGSGL 179
Cdd:cd17347  121 SAFGGDQFGADQqhlLARFFSWFYFAINAGSLL 153
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 77-180 3.98e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.10  E-value: 3.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  77 FTVAVFISSYMVL----APVFGYLGDRYNRKYLMCGGIAFwSLVTLGSSFIPGeHFWLLLLTRGLVGVGeASYSTIAPTL 152
Cdd:cd17330   34 YYVGLLQSSYSLGqflaSPLWGRLSDRYGRKPVLLLSLAG-SAVSYVLLGLSR-NLWLLFLARFLDGLT-GGNVSVAQAY 110

                         90       100
                 ....*....|....*....|....*...
gi 215490098 153 IADLFVADQRSRMLSIFYFAIPVGSGLG 180
Cdd:cd17330  111 IADITDEEERAKAFGIISAAFGLGFILG 138
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
 89-198 6.01e-03

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 38.96  E-value: 6.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  89 LAPVFG-YLGDRYNRKY--------LMCGGIAFWSLVTLGSSFIP------------GEHFWLLLLTRGLVGVGEASYST 147
Cdd:cd06175   50 VTPLFGgWIADTFLGRYrtiligaaIYAVGVAILTVSTIPPGLRPlrcnpshceqasGIQLTGFYAALYLIALGTGGVKA 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215490098 148 IAPTLIADLFVADQRSRMLS---IFYFAIPVGSGLGYIAGSKVKDMAGdWHWAL 198
Cdd:cd06175  130 NVSPLGADQFDERGPSKTQSffnWFYFCINVGSLLAMLGTPYIQDNVG-WAAAY 182
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 87-185 6.40e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 38.76  E-value: 6.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  87 MVLAPVFGYLGDRYN------RKYLMCGGIA---FWSLV----TLGSSFIPGEHFW-LLLLTRGLVGVGEASYSTIAPT- 151
Cdd:cd17313   48 LFVQPLVGSLSDRCNsrigrrRPFILVGAPLaalGLILIpnaaDIGLALGDGPRTWaLVLFVLGIVLLDFAMNVCQGPVr 127

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 215490098 152 -LIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGS 185
Cdd:cd17313  128 aLLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGA 162
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
 114-197 6.97e-03

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 38.45  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490098  114 SLVTLGS--SFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQ---RSRMLSIFYFAIPVGSGLGYIAGSKVK 188
Cdd:pfam00854  16 ILLALSAipSLRPPVHVALFFIGLALIALGTGGIKPNVSSFGGDQFEETDprrRSRFFSIFYFSINAGSLISTIITPYLQ 95


                  ....*....
gi 215490098  189 DMAGdWHWA 197
Cdd:pfam00854  96 QNYG-YPLG 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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