NCBI Conserved Domain Search

Conserved domains on [gi|215490102|ref|NP_001135923|]

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protein spinster homolog 1 isoform 3 [Homo sapiens]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH: 1.20.1250.20

Gene Ontology: GO:0022857|GO:0055085|GO:0006869

PubMed: 26758938|26098515

SCOP: 3000310

TCDB: 2.A.1.49

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

62-427

1.27e-167

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 478.27 E-value: 1.27e-167

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLG 141
Cdd:cd17328    1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 142 SSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALR 221
Cdd:cd17328   81 SSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 222 VTPGLGVVAVLLLFLVVREPPRGAVERHsDLPPLNPTSWWADLRALARN------------------------------- 270
Cdd:cd17328  159 VTGVLGVLLAILLLLFVREPPRGAAEGG-VMAKSTATSFLADLKALAKNpsfilstlgftavsfvtgalafwaptfflra 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 271 ------------LIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFI 338
Cdd:cd17328  238 fgvgdlssadvgLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 339 GETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNwPPSFLSEFRALQFSLMLCAFV 418
Cdd:cd17328  318 GEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFV 396


                 ....*....
gi 215490102 419 GALGGAAFL 427
Cdd:cd17328  397 LVLGGFFFL 405

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

62-427

1.27e-167

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 478.27 E-value: 1.27e-167

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLG 141
Cdd:cd17328    1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 142 SSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALR 221
Cdd:cd17328   81 SSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 222 VTPGLGVVAVLLLFLVVREPPRGAVERHsDLPPLNPTSWWADLRALARN------------------------------- 270
Cdd:cd17328  159 VTGVLGVLLAILLLLFVREPPRGAAEGG-VMAKSTATSFLADLKALAKNpsfilstlgftavsfvtgalafwaptfflra 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 271 ------------LIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFI 338
Cdd:cd17328  238 fgvgdlssadvgLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 339 GETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNwPPSFLSEFRALQFSLMLCAFV 418
Cdd:cd17328  318 GEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFV 396


                 ....*....
gi 215490102 419 GALGGAAFL 427
Cdd:cd17328  397 LVLGGFFFL 405

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

60-427

2.38e-28

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 115.35 E-value: 2.38e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  60 LIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVT 139
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 140 LGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 219
Cdd:COG2271   90 LLFGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 220 LRVT------PGLGVVAVLLLFLVVREPPRGAVERHSdlpplnpTSWWADLRALARNL--IFGLITCLTGVLGVGLGVEI 291
Cdd:COG2271  167 FLILglpgllLALLRFWLLALAYFLVYFALYGFLTWL-------PTYLVEVRGLSLAQagLLLSLPFLAGIVGSLLGGWL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 292 SRRLRhsnpRADPLVCATGLLGSAPFLFLSLACarGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFqI 371
Cdd:COG2271  240 SDRLG----RRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-V 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215490102 372 VLSHLLGDAGSPYLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGALGGAAFL 427
Cdd:COG2271  313 NTFGFLGGALGPLLVGYLLDAT-------------GYQAAFLLLAALALLAALLAL 355

MFS_1

pfam07690

Major Facilitator Superfamily;

65-359

1.14e-18

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.09 E-value: 1.14e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102   65 LCYINLLNYMDRFTVAGVLP-DIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSS 143
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  144 FIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVT 223
Cdd:pfam07690  81 FASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  224 PGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNLIFGLITCLTGVLGVGLGVEISRRLRHSNPRAD 303
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLA 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 215490102  304 PLVCA-TGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVI 359
Cdd:pfam07690 238 GLLLGlGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294

2A0104

TIGR00881

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...

70-243

4.14e-10

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 61.24 E-value: 4.14e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102   70 LLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeH 149
Cdd:TIGR00881   5 AAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST--S 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  150 FWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVV 229
Cdd:TIGR00881  83 LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAII 162

                         170
                  ....*....|....
gi 215490102  230 AVLLLFLVVREPPR 243
Cdd:TIGR00881 163 VSLICFLLLRDSPQ 176

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

62-427

1.27e-167

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 478.27 E-value: 1.27e-167

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLG 141
Cdd:cd17328    1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 142 SSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALR 221
Cdd:cd17328   81 SSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 222 VTPGLGVVAVLLLFLVVREPPRGAVERHsDLPPLNPTSWWADLRALARN------------------------------- 270
Cdd:cd17328  159 VTGVLGVLLAILLLLFVREPPRGAAEGG-VMAKSTATSFLADLKALAKNpsfilstlgftavsfvtgalafwaptfflra 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 271 ------------LIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFI 338
Cdd:cd17328  238 fgvgdlssadvgLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 339 GETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNwPPSFLSEFRALQFSLMLCAFV 418
Cdd:cd17328  318 GEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFV 396


                 ....*....
gi 215490102 419 GALGGAAFL 427
Cdd:cd17328  397 LVLGGFFFL 405

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

60-427

2.38e-28

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 115.35 E-value: 2.38e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  60 LIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVT 139
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 140 LGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 219
Cdd:COG2271   90 LLFGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 220 LRVT------PGLGVVAVLLLFLVVREPPRGAVERHSdlpplnpTSWWADLRALARNL--IFGLITCLTGVLGVGLGVEI 291
Cdd:COG2271  167 FLILglpgllLALLRFWLLALAYFLVYFALYGFLTWL-------PTYLVEVRGLSLAQagLLLSLPFLAGIVGSLLGGWL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 292 SRRLRhsnpRADPLVCATGLLGSAPFLFLSLACarGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFqI 371
Cdd:COG2271  240 SDRLG----RRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-V 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215490102 372 VLSHLLGDAGSPYLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGALGGAAFL 427
Cdd:COG2271  313 NTFGFLGGALGPLLVGYLLDAT-------------GYQAAFLLLAALALLAALLAL 355

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

65-427

1.20e-25

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 107.90 E-value: 1.20e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  65 LCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSF 144
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 145 IPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG-DWHWALRVT 223
Cdd:cd06174   81 APS--FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 224 PGLGVVAVLLLFLVVREPPRGAVERHSdlpPLNPTSWWADLRALARN--------------------------------- 270
Cdd:cd06174  159 AALALLAAILLLLVVPDPPESARAKNE---EASSKSVLKLLKRVLKNpglwllllaiflvnlayysfstllplflldlgg 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 271 ------LIFGLITCLTGVLGVGLGVEISRRLRhsnPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLS 344
Cdd:cd06174  236 lsvavaGLLLSLFGLAGALGSLLLGLLSDRLI---GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 345 MNWAIVADIllyvVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGALGGA 424
Cdd:cd06174  313 LSFALIAEL----FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF-------------GLTGAFLVLAVLLLLAAI 375


                 ...
gi 215490102 425 AFL 427
Cdd:cd06174  376 LLL 378

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

54-289

1.46e-22

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 98.51 E-value: 1.46e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  54 SPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIA 133
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 134 FWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMA 213
Cdd:COG2814   84 LFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215490102 214 GdWHWALRVTPGLGVVAVLLLFLVVREPprgaverhsdlPPLNPTSWWADLRALARNLIFGLITCLTGVLGVGLGV 289
Cdd:COG2814  162 G-WRWVFLVNAVLALLALLLLLRLLPES-----------RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFA 225

MFS_1

pfam07690

Major Facilitator Superfamily;

65-359

1.14e-18

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.09 E-value: 1.14e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102   65 LCYINLLNYMDRFTVAGVLP-DIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSS 143
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  144 FIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVT 223
Cdd:pfam07690  81 FASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  224 PGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNLIFGLITCLTGVLGVGLGVEISRRLRHSNPRAD 303
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLA 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 215490102  304 PLVCA-TGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVI 359
Cdd:pfam07690 238 GLLLGlGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

50-339

3.63e-18

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 84.86 E-value: 3.63e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  50 ITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMC 129
Cdd:COG0477    4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 130 GGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKV 209
Cdd:COG0477   84 IGLLLFGLASLLCGLAPS--PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 210 KDMAGdWHW-----ALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNLIFGLITCLTGVLG 284
Cdd:COG0477  162 VAALG-WRWiflinAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215490102 285 VGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIG 339
Cdd:COG0477  241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

60-219

2.33e-17

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 83.39 E-value: 2.33e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  60 LIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVT 139
Cdd:cd17319    3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 140 LGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 219
Cdd:cd17319   83 ALTGFATS--LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG-WRWA 159

MFS_SLC17A9_like

cd17380

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...

62-218

1.72e-15

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 77.59 E-value: 1.72e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLG 141
Cdd:cd17380    1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215490102 142 SSFIPGEHFWLLLLTRGLVGVGEA-SYSTIApTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 218
Cdd:cd17380   81 TPLLAYSSLPLLILSRILLGLGEGvHFPSMT-SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPS 156

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

65-206

1.77e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.92 E-value: 1.77e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  65 LCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSF 144
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215490102 145 IPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAG 206
Cdd:cd17325   81 AT--SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG 140

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

64-199

9.59e-14

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 72.61 E-value: 9.59e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  64 VLCYINLLNYMDRFTVAGVLPDI-EQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGS 142
Cdd:cd17473    3 TLLLASTLTVMAGAAIAPALPAIaQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215490102 143 SFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGS 199
Cdd:cd17473   83 LFLDS--LYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGG 137

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

62-218

1.43e-13

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 71.83 E-value: 1.43e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLG 141
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215490102 142 SSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSkvkdMAGDWHW 218
Cdd:cd17474   81 CGLSDS--FALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG----LLAAISW 151

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

57-222

1.64e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 68.75 E-value: 1.64e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  57 RSALIVAVLCYinLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWS 136
Cdd:COG2223    4 WRVLLLATLAF--FLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 137 LVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdW 216
Cdd:COG2223   82 IGLLLLALAVS--YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-W 158


                 ....*.
gi 215490102 217 HWALRV 222
Cdd:COG2223  159 RNAFLI 164

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

79-219

4.28e-12

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 67.60 E-value: 4.28e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  79 VAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRG 158
Cdd:cd17504   15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAP--NLPVLIAGRA 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215490102 159 LVGVGEASYsTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 219
Cdd:cd17504   93 LQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-WRWI 151

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

68-220

5.65e-12

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.86 E-value: 5.65e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  68 INLLNYMDRFTVAGVLPDIEQFFNiGDSSSGLIQTVFISSY---MVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSF 144
Cdd:cd17316    7 GWFFDAYDFFLIGFVAPVLAAEFS-LGLSLLQTGLLFAAGFlgrPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGL 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215490102 145 IPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGD---WHWAL 220
Cdd:cd17316   86 LPT--PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgWRILF 162

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

77-431

9.94e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 66.42 E-value: 9.94e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  77 FTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLT 156
Cdd:cd17324   16 YVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS--FALLLLA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 157 RGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLLLFL 236
Cdd:cd17324   94 RALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLALLAALLLWR 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 237 VVREPPRgaverHSDLPPLNPTSWWADLRALARNLIFGLITCLTGVLGVG---LGVEISRRLRHSNPRADPLvcatgllg 313
Cdd:cd17324  173 LLPSLPP-----KKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALytyLAPFLTDVPGFSSSAIIGL-------- 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 314 sapFLFLSLACARGSIVATYIF-IFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLShLLGDAGSPYLIGLISDR 392
Cdd:cd17324  240 ---LLLFGVAGVVGSPLAGRLAdRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWG-LGFFAAHSALQTRVLRL 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 215490102 393 LRRNwppsflsefRALQFSL-MLCAFVGALGGAAFLGTAI 431
Cdd:cd17324  316 APEA---------RGLASSLyLAAYNLGGALGAALGGLVL 346

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

62-214

3.43e-11

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.52 E-value: 3.43e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCYINLLNYMDRFTVAGVLP-DIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTL 140
Cdd:cd17325  201 LLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215490102 141 GSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG 214
Cdd:cd17325  281 LLPLATS--FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

62-218

1.31e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 62.98 E-value: 1.31e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLG 141
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215490102 142 SSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDmAGDWHW 218
Cdd:cd17323   81 CALAP--NIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQ-SLGWRW 154

Sugar_tr

pfam00083

Sugar (and other) transporter;

75-218

1.60e-10

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 63.06 E-value: 1.60e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102   75 DRFTVAGVLPDIEQFFNIG-------DSSSGLIQTVFISSYMVLAPV----FGYLGDRYNRKYLMCGGIAFWSLVTLGSS 143
Cdd:pfam00083  15 DTGVIGAFLTLIDFFKNFGlsksvssLAALSVLSGLIVSIFSVGCFIgslfAGKLGDRFGRKKSLLIANVLFVIGAVLQG 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215490102  144 FIPG-EHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHW 218
Cdd:pfam00083  95 AAKGkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGW 170

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

77-218

2.96e-10

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 61.81 E-value: 2.96e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  77 FTVAGV-LPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLL 155
Cdd:cd17321   12 VTIVNVaLPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--LAFLIA 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215490102 156 TRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 218
Cdd:cd17321   90 ARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRW 151

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

79-427

3.03e-10

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 61.80 E-value: 3.03e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  79 VAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRG 158
Cdd:cd17478   15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN--YWLLLLLVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 159 LVGVGEASYSTIAPTLIADLFvADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVv 238
Cdd:cd17478   93 LAGIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 239 rePPRGAVERHSDLPPLNPTSWWADLRALArnLIFGLITC----------------------------------LTGVLG 284
Cdd:cd17478  171 --PLKKPEAKKAAAKSSARSTLKGVWRALL--LLLIIVFLrswvlsslttflpfylvqrgyslvfaglllslflFAGAIG 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 285 VGLGVEISRRLRHSNpradplVCATGLLGSAPFLFLSLACargSIVATYIFIFIGETLLSMNWAIvadILLYV--VIPTR 362
Cdd:cd17478  247 TLIGGPLSDRFGRRR------VIIASLLLAAPFLLLFLLT---PGIWSYILLVLAGFLLFASFPV---TVVLAqeLLPGN 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215490102 363 RSTAEAFQIVLSHLLGDAGSPyLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGALGGAAFL 427
Cdd:cd17478  315 VGLASGLMMGLSFGLGGIGAP-VLGALADAF-------------GLESVLLILALLPLLGALLAF 365

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

78-222

3.75e-10

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.41 E-value: 3.75e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  78 TVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTR 157
Cdd:COG0738   26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--YPLLLLAL 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215490102 158 GLVGVGEASYSTIAPTLIADLFvADQRSRMLSIFYFAIPVGSGLGYIAGSKV--KDMAGDWHWALRV 222
Cdd:COG0738  104 FLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLilLGLSLSWHLPYLI 169

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

64-214

3.83e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.84 E-value: 3.83e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  64 VLCYINLLNYMDRFTVAGVLP-DIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGS 142
Cdd:COG2211  232 LLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215490102 143 SFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQ-------RSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG 214
Cdd:COG2211  312 FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFG 390

2A0104

TIGR00881

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...

70-243

4.14e-10

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 61.24 E-value: 4.14e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102   70 LLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeH 149
Cdd:TIGR00881   5 AAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST--S 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  150 FWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVV 229
Cdd:TIGR00881  83 LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAII 162

                         170
                  ....*....|....
gi 215490102  230 AVLLLFLVVREPPR 243
Cdd:TIGR00881 163 VSLICFLLLRDSPQ 176

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

59-220

5.94e-10

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.04 E-value: 5.94e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  59 ALIVAVLCYINLlnymdRFTVAGV---LPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFW 135
Cdd:COG2807   19 LLLAIVLVALNL-----RPAITSVgplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 136 SLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFvADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGd 215
Cdd:COG2807   94 AAGLLLRSLAPS--VALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG- 169


                 ....*
gi 215490102 216 WHWAL 220
Cdd:COG2807  170 WRGAL 174

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

99-223

7.17e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 57.21 E-value: 7.17e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  99 LIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADL 178
Cdd:cd17317   29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 215490102 179 FVADQRSRMLSIFYFAIPVG----SGLGYIagskvkdmAGDWHWALRVT 223
Cdd:cd17317  107 VGPKYRSFVGILFGLFWALGymllALLAYL--------IRDWRWLQLAI 147

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

62-220

8.44e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.21 E-value: 8.44e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLG 141
Cdd:cd17365    1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215490102 142 SSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWAL 220
Cdd:cd17365   81 TAFAQS--VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVF 156

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

62-201

2.96e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.37 E-value: 2.96e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCYINLLNYMDRFTVAGVLPDI-EQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTL 140
Cdd:COG2814  209 LLLLLLLAFLLGFGFFALFTYLPLYlQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215490102 141 GSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGL 201
Cdd:COG2814  289 LLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

79-220

6.91e-08

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 54.50 E-value: 6.91e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  79 VAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNR-KYLMCGGIAFwSLVTLGSSFIPgeHFWLLLLTR 157
Cdd:cd17359   20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRrKTLLISAVLF-FISALGSAFSP--NFTIFIIAR 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 158 GLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGD-------WHWAL 220
Cdd:cd17359   97 IIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGAdwlgaegWRWML 166

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

92-207

1.93e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.93 E-value: 1.93e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  92 IGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGssFIPGEHFWLLLLTRGLVGVGEASYSTIA 171
Cdd:cd17370  231 LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLG--FALGSSLWLLLLGFILWGLYMGAQESIE 308

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 215490102 172 PTLIADLFVADQRSRMLSIFYFaipvGSGLGYIAGS 207
Cdd:cd17370  309 RAAVADLVPAELRGTAYGLFNT----VVGIGWLLAS 340

MFS_SLCO_OATP

cd17336

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...

62-207

2.53e-07

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 52.63 E-value: 2.53e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNR-KYLMCGGIafwsLVTL 140
Cdd:cd17336    5 VVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRpRWIGIGSI----LMGL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 141 GS--SFIPgeHFWLLLLTrgLVGVGEASYSTIAPTLIADlFVADQRSRMLSIFYFAIPV-GSGLGYIAGS 207
Cdd:cd17336   81 GCflLALP--HFLFVGQF--LLGIGSSPLYTLGITYIDD-NVSKKNSPLYIGILYAMRVlGPALGFLLGS 145

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

83-190

3.31e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 52.19 E-value: 3.31e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  83 LPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGV 162
Cdd:cd17320   22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS--SIEQLLIARFLQGL 99

                         90       100
                 ....*....|....*....|....*...
gi 215490102 163 GEASYSTIAPTLIADLFVADQRSRMLSI 190
Cdd:cd17320  100 GAAAGSVVARAIVRDLYSGAELAKIFSL 127

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

62-216

3.41e-07

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 52.19 E-value: 3.41e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  62 VAVLCyiNLLNYMDRFTVAGVLPDIEQFFNIGDSSSglIQTVFISSYMVLAPV----FGYLGDRYNRKYLMCGGIAFWSL 137
Cdd:cd17315    1 VAALG--GLLFGYDLGVINGALLYIAKDLGFGLSTS--LQGLVVSSLLLGAAIgslfGGPLADRFGRRKSLLIAAVLYVI 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215490102 138 VTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDW 216
Cdd:cd17315   77 GALLSALAPN--VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGW 153

2A0119

TIGR00898

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

98-218

7.36e-07

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 51.56 E-value: 7.36e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102   98 GLIQTVFISSYMVLAPVFGYLGDRYNRKYLMcggiaFWS-LVTLGSSFIPG--EHFWLLLLTRGLVGVGEASYSTIAPTL 174
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVL-----LLStLVTAVSGVLTAfsPNYTVFLVFRLLVGMGIGGIWVQAVVL 204

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 215490102  175 IADLFVADQRsRMLSIFYFaipVGSGLGYIAGSKVKDMAGDWHW 218
Cdd:TIGR00898 205 NTEFLPKKQR-AIVGTLIQ---VFFSLGLVLLPLVAYFIPDWRW 244

MFS_SLCO4_OATP4

cd17403

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...

77-216

9.13e-07

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340961 [Multi-domain] Cd Length: 420 Bit Score: 51.10 E-value: 9.13e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  77 FTVAGVLP----DIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNR-KYLMCGGIafwsLVTLGS--SFIPgeH 149
Cdd:cd17403   17 MVVNGFVNvsitTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKpRWLGIGAF----IMGIGSlvFALP--H 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215490102 150 FWLLLLTRGLVGVGEASYSTIAPTLIaDLFVADQRSRM-LSIFYFAIPVGSGLGYIAGSKVKDMAGDW 216
Cdd:cd17403   91 FTVFILAQLLHGAGATPLYTLGVTYL-DENVSTKMSPLyIGIFYAMAILGPAIGYVLGGFLLNLYTDI 157

MFS_OPA_SLC37

cd17312

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...

59-224

9.97e-07

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 50.74 E-value: 9.97e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  59 ALIVAVLCYinLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLV 138
Cdd:cd17312    4 IFLGVFLGY--AAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 139 TLGSSFipGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDmAGDWHW 218
Cdd:cd17312   82 NIFMGF--STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLAS-YYGWRA 158


                 ....*.
gi 215490102 219 ALRVTP 224
Cdd:cd17312  159 AFLVPG 164

OATP

pfam03137

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...

81-225

2.03e-06

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.

Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 50.28 E-value: 2.03e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102   81 GVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNR-KYLMCGGIafwsLVTLGS--SFIPgeHFWLLLLTR 157
Cdd:pfam03137  22 SSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRpRWIGVGAL----LMGLGSllFALP--HFLSFFLGQ 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215490102  158 GLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWH-WALRVTPG 225
Cdd:pfam03137  96 LLLGIGGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGkVSITLTPK 164

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

57-202

2.25e-06

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.52 E-value: 2.25e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  57 RSALIVAVLcyINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFIS-SYMVLAPVFGYLGDRYNRKYLMCGGIAFW 135
Cdd:cd17316  176 RRRTLLLIL--LWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISlGALVGALIAGLLSDRIGRKKTLVIGLILS 253

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215490102 136 SLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLG 202
Cdd:cd17316  254 GILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGA 320

MFS_SLCO5_OATP5

cd17404

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...

59-207

2.32e-06

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340962 [Multi-domain] Cd Length: 425 Bit Score: 49.66 E-value: 2.32e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  59 ALIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIqtvfISSY---MVLAPVF-GYLGDRYNR-KYLMCGGIa 133
Cdd:cd17404    2 AFLVCMCLLIFIQSALSSGYLNSVITTIEKRYSLKSSESGLI----VSSYeigSLLTVVFvSYFGGRGHRpRWIAVGGV- 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215490102 134 fwsLVTLGSSFIPGEHFwlLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGS 207
Cdd:cd17404   77 ---LIALGSFLFSLPHF--FILAQILIGMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGG 145

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

54-206

2.48e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.66 E-value: 2.48e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102   54 SPGRSALIVAVLCY-INLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGI 132
Cdd:TIGR00895  10 PLSRYQWRAIILSFlIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSI 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215490102  133 AFWSLVTLGSSFipGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVG-SGLGYIAG 206
Cdd:TIGR00895  90 LLFSVFTLLCAL--ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGaAVGGFLAG 162

MFS_LmrB_MDR_like

cd17503

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...

78-218

2.49e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.50 E-value: 2.49e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  78 TVAGV-LPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLT 156
Cdd:cd17503   13 TIVNVaLPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAP--NLASLIIF 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215490102 157 RGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 218
Cdd:cd17503   91 RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLS-WRW 151

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

88-207

3.02e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.15 E-value: 3.02e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  88 QFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIpgEHFWLLLLTRGLVGVGEASY 167
Cdd:cd17329   28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA--HSPWLFAIALVLTGFGGGLF 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 215490102 168 STIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGS 207
Cdd:cd17329  106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGG 145

MFS_MucK

cd17371

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...

70-201

6.30e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.45 E-value: 6.30e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  70 LLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGeh 149
Cdd:cd17371    9 ALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQN-- 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215490102 150 FWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGL 201
Cdd:cd17371   87 YWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLL 138

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

92-214

6.97e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 6.97e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  92 IGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIA 171
Cdd:cd17489  224 RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGS--PWMLLLAAVLYGLGFGLLFPAL 301

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 215490102 172 PTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG 214
Cdd:cd17489  302 QALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG 344

MFS_Azr1_MDR_like

cd17502

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...

65-218

8.83e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 47.56 E-value: 8.83e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  65 LCYINLLNYMDRFTVAGVLPDIEQFFNiGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSF 144
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215490102 145 IPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 218
Cdd:cd17502   80 APN--MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS-WRW 150

synapt_SV2

TIGR01299

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...

4-189

1.07e-05

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.

Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 48.05 E-value: 1.07e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102    4 SDTAPFLSQADDPDDGPVPgtPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSALIVaVLCYINLLNYMDRFTVAGVL 83
Cdd:TIGR01299 114 ADGAPKAGVRDELKDGEGP--PGGEGEAERRADEEELAQQYELIIQECGHGRFQWALFF-VLGLALMADGVEVFVVGFVL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102   84 PDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWllLLTRGLVGVG 163
Cdd:TIGR01299 191 PSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFF--LFCRLLSGFG 268

                         170       180
                  ....*....|....*....|....*.
gi 215490102  164 EASYSTIAPTLIADLFVADQRSRMLS 189
Cdd:TIGR01299 269 IGGAIPIVFSYFAEFLAQEKRGEHLS 294

MFS_TRI12_like

cd06179

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...

80-218

1.20e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 47.62 E-value: 1.20e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  80 AGVLPDIEQffNIGDSS-SGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFW---SLVTLGSSFIPGehfwlLLL 155
Cdd:cd06179   18 AAVLPFIVA--DLGPSSnSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGvvgSIVAGTAKSVNM-----LIG 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215490102 156 TRGLVGVGeASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLG-YIAGSKVKDMAGDWHW 218
Cdd:cd06179   91 GQALIGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGpLIAGALVEANAAGWRW 153

MFS_SVOPL

cd17442

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...

74-223

1.45e-05

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 47.11 E-value: 1.45e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  74 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgEHFWLL 153
Cdd:cd17442   15 MEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAP-SYIWFV 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215490102 154 LLtRGLVGVGEASYSTiAPTLIADLFVADQRSRML---SIFYFAipvGSGLGYIAGSKVKDMAGdWHWALRVT 223
Cdd:cd17442   94 FL-RCMVGCGVSGHSQ-GLIIKTEFLPTKYRGYMLplsQIFWLA---GSLLIIGLASVVIPTLG-WRWLIRFA 160

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

77-220

1.89e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.80 E-value: 1.89e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  77 FTVAGVLPDI-EQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGeHFWLLLL 155
Cdd:COG2223  222 IGFSSWLPPYlVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG-SLWLFLV 300

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215490102 156 TRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWAL 220
Cdd:COG2223  301 LFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAF 365

MFS_FEN2_like

cd17327

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...

61-202

2.29e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 46.47 E-value: 2.29e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  61 IVAVLCYINLLNYMDRFTV--AGVLPDIEQFFNIGDSSSgLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLV 138
Cdd:cd17327    6 ILPLLCILYFLQYLDKSNIsnAAVMGMKEDLKLVGNQYN-WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215490102 139 TLGSSFIpgEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLG 202
Cdd:cd17327   85 TLLTAAV--KNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG 146

MFS_HXT

cd17356

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...

68-204

4.76e-05

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 45.70 E-value: 4.76e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  68 INLLNYMDRFtvagvlPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPG 147
Cdd:cd17356   24 LNMKSFQKYF------ADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIG 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215490102 148 EhFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYI 204
Cdd:cd17356   98 K-WYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYC 153

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

65-388

6.20e-05

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.28 E-value: 6.20e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  65 LCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSF 144
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 145 IPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdwHWALRVTP 224
Cdd:cd17489   81 ATS--VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 225 GLGVVAVLLLFLVVREPPRGAVERHSDLPP-----LNPTSWWADLRALARNLIFGLITCLTGVLGVGLGveisrrlrHSN 299
Cdd:cd17489  157 AVLALLALLLVFLVKDPPPVAAEEAEAGTRafrrlVEKKVLPPALILFLASIAYGAISTFLPLYAAERG--------ISN 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 300 PRADPLVCATGLLGSAPFlFLSLACARG---SIVATYIFIFIGETLLSMN---WAIVADILLY-----VVIPTrrSTAEA 368
Cdd:cd17489  229 AGLFFTVYAIALLLSRPF-SGKLSDRKGpktVIIPGLLLLALGLLLLSFAgspWMLLLAAVLYglgfgLLFPA--LQALA 305

                        330       340
                 ....*....|....*....|
gi 215490102 369 FQIVLSHLLGDAGSPYLIGL 388
Cdd:cd17489  306 VDLVPPHRRGAANGTFFIFF 325

MFS_DtpA_like

cd17346

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...

89-219

7.98e-05

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 44.87 E-value: 7.98e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  89 FFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRY--NRKYLMCGGIafwsLVTLG--SSFIPGEHFWLLLLTRGLVGVGE 164
Cdd:cd17346   34 GDGFSEADAASIYGAYTALVYLTPIIGGWLADKVlgARRTVFIGGI----LMALGylLLALSPFSVSMLYLGLALIIVGN 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215490102 165 ASYSTIAPTLIADLFVADQ--RSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 219
Cdd:cd17346  110 GLFKPNISSLVGKLYDENDprRDSGFSIFYMGINLGAFLAPLLCGTLGDNYG-YHYG 165

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

82-202

1.50e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.72 E-value: 1.50e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  82 VLPD-IEQFFNIGDSS--SGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFwSLVTLGSSFIPGeHFWLLLLTRG 158
Cdd:cd17330   18 VLPFyVREFNKLGASGyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAG-SAVSYVLLGLSR-NLWLLFLARF 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 215490102 159 LVGVGeASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLG 202
Cdd:cd17330   96 LDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILG 138

MFS_Amf1_MDR_like

cd17476

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...

63-219

1.81e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 43.79 E-value: 1.81e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  63 AVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGS 142
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215490102 143 SFIPGEHFwlLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRM-LSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 219
Cdd:cd17476   81 GFSPNFIF--FIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIvFSLFGATAPLGFALGGVFGGLFAQLAW-WPWI 155

MFS_POT

cd06175

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...

67-220

2.03e-04

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340865 [Multi-domain] Cd Length: 422 Bit Score: 43.58 E-value: 2.03e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  67 YINLLNYMDRFTVAGVLPDIEQFFNIG----DSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKY--------LMCGGIAF 134
Cdd:cd06175    3 MILLIELCERFTFYGIGANLVPFLTGAlglgNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYrtiligaaIYAVGVAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 135 WSLVTLGSSFIP------------GEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLS---IFYFAIPVGS 199
Cdd:cd06175   83 LTVSTIPPGLRPlrcnpshceqasGIQLTGFYAALYLIALGTGGVKANVSPLGADQFDERGPSKTQSffnWFYFCINVGS 162

                        170       180
                 ....*....|....*....|.
gi 215490102 200 GLGYIAGSKVKDMAGdWHWAL 220
Cdd:cd06175  163 LLAMLGTPYIQDNVG-WAAAY 182

MFS_SVOP_like

cd17372

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...

74-223

2.13e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 43.29 E-value: 2.13e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  74 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgEHFWLL 153
Cdd:cd17372   13 MEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAP-NYMWLI 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 154 LLtRGLVGVGEASYSTIApTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVT 223
Cdd:cd17372   92 IL-RCLVGLGLGGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG-WRWLLAFS 158

MFS_MelB_like

cd17332

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...

60-178

3.38e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.98 E-value: 3.38e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  60 LIVAVLCYINLLNymdrfTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVT 139
Cdd:cd17332  226 LLLAYLLYFLAFN-----IVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGL 300

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 215490102 140 LGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADL 178
Cdd:cd17332  301 LLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADV 339

MFS_SLC17

cd17318

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...

83-205

3.75e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 42.61 E-value: 3.75e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  83 LPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLgssFIP---GEHFWLLLLTRGL 159
Cdd:cd17318   44 LPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTL---LTPlaaRGGYGALIVLRIL 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215490102 160 VGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGL-----GYIA 205
Cdd:cd17318  121 QGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIamplsGFLC 171

MFS_SV2A

cd17439

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...

77-189

5.96e-04

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 42.32 E-value: 5.96e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  77 FTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLT 156
Cdd:cd17439   16 FVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQG--YGTFLFC 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 215490102 157 RGLVGVGEASYSTIAPTLIADLFVADQRSRMLS 189
Cdd:cd17439   94 RLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLS 126

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

59-220

6.35e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.78 E-value: 6.35e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  59 ALIVAVLCYINLLNYMDRFTVAGVLPDI-EQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNR--KYLMCGGIAFW 135
Cdd:COG2271  179 LLRFWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLA 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 136 SLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGd 215
Cdd:COG2271  259 ALALLLLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG- 335


                 ....*
gi 215490102 216 WHWAL 220
Cdd:COG2271  336 YQAAF 340

MFS_GLUT10_12_Class3_like

cd17362

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...

114-218

8.66e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.57 E-value: 8.66e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 114 VFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYF 193
Cdd:cd17362   58 VAGALIDRLGRRKELILAALLYLVGSLVTGLAPS--YPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKEL 135

                         90       100
                 ....*....|....*....|....*
gi 215490102 194 AIPVGSGLGYIAGSKVKDMAGDWHW 218
Cdd:cd17362  136 FIVLGILLGYVSGYAFADVVGGWRY 160

MFS_HMIT_like

cd17360

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...

79-220

1.22e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 41.10 E-value: 1.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  79 VAGVLPDIEQFFNIGDSSSGLiQTVFISSYMVLAPVF----GYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLL 154
Cdd:cd17360   16 ISGALLYIKDDLGEVVLSTGW-QELIVSSTVAGAAVGaaigGWLNDRFGRRPCILLADALFTIGAIVMAAAP--NKEVLI 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215490102 155 LTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWAL 220
Cdd:cd17360   93 VGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWML 158

MFS_SV2

cd17363

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...

77-189

1.54e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 40.94 E-value: 1.54e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  77 FTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLT 156
Cdd:cd17363   16 FVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQG--YGFFLFC 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 215490102 157 RGLVGVGEASYSTIAPTLIADLFVADQRSRMLS 189
Cdd:cd17363   94 RLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLS 126

2A0114euk

TIGR00894

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]

56-192

1.57e-03

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]

Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.88 E-value: 1.57e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102   56 GRSALIVAVLCYINLLNYMDrFTVAGVLPDIEQFFNIGDSSSGLIQTVFISS----YMVLAPVFGYLGDRYNRKYLMCGG 131
Cdd:TIGR00894  34 QRICLSLTMVAMVNKENSTD-LACLSAENELDNIKNPNFKWSGALQGLILSShfygQIIIQIPVGYLAGKYVFKWSIGIG 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215490102  132 IAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFY 192
Cdd:TIGR00894 113 MFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMST 173

MFS_GLUT6_8_Class3_like

cd17358

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...

78-207

1.60e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 40.64 E-value: 1.60e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  78 TVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLM----CGGIAFWSLVTLGSSFipgehfWLL 153
Cdd:cd17358   24 ALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLlisaIPCILGWLLIAFAKDV------WML 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215490102 154 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGS 207
Cdd:cd17358   98 YLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGS 151

MFS_OAT

cd17374

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...

101-218

2.10e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 40.35 E-value: 2.10e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 101 QTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLfv 180
Cdd:cd17374   41 QSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPT--FPVYCVLRFLAGFAVSGISINTLILGTEW-- 116

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 215490102 181 ADQRSRMLSIFYFAIPVGSGLGYIAGskVKDMAGDWHW 218
Cdd:cd17374  117 TTPRHRALAITLTSCFFSIGQMLLAG--LAYAIRDWRL 152

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

98-206

2.49e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.49e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  98 GLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCG---GIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTL 174
Cdd:cd06173   37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadlLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQAL 116

                         90       100       110
                 ....*....|....*....|....*....|..
gi 215490102 175 IADLFVADQRSRMLSIFYFAIPVGSGLGYIAG 206
Cdd:cd06173  117 LPELVPKEQLVRANALNSLATQLARIIGPALG 148

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

33-207

2.96e-03

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.96e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  33 NPKSEEPEVPDQEGLQRITGLSPGRSALIVAVL--CYINLLnymdrFTVAGVLPDI-EQFFNIGDSSSGLIQTVFISSYM 109
Cdd:cd17474  174 PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSafLYFFLY-----FAFLTYLPFLlELLYGISPIIIGLLFAGWSVLLA 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 110 VLAPVFGY-LGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRML 188
Cdd:cd17474  249 LGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPS--LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTAS 326

                        170
                 ....*....|....*....
gi 215490102 189 SIFYFAIPVGSGLGYIAGS 207
Cdd:cd17474  327 SLYNFVRFLGQAVGPLLFG 345

MFS_SV2B

cd17438

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...

74-189

3.71e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 39.52 E-value: 3.71e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  74 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLL 153
Cdd:cd17438   13 VEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQG--YGAF 90

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 215490102 154 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLS 189
Cdd:cd17438   91 LFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLS 126

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

48-220

3.74e-03

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.47 E-value: 3.74e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  48 QRITGLSPGRSALIVAVLCY--INLLNYmdrFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRY-NR 124
Cdd:COG2807  204 AAASLRSLWRSPLAWLLTLFfgLQSLLY---YAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLgDR 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 125 KYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLtrgLVGVGEASYSTIAPTLIADLFVADQRSRMLS-----IFYfaipVGS 199
Cdd:COG2807  281 RPLLLLLGLLGLAGLLGLLLAPGSLPWLWAV---LLGLGQGGLFPLALTLIGLRARTPAEAAALSgmaqsVGY----LLA 353

                        170       180
                 ....*....|....*....|.
gi 215490102 200 GLGYIAGSKVKDMAGDWHWAL 220
Cdd:COG2807  354 ALGPLLVGALHDATGSWTAAL 374

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

91-215

4.64e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.08 E-value: 4.64e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  91 NIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYsTI 170
Cdd:cd17477  219 GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLY-TL 297

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 215490102 171 APTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGD 215
Cdd:cd17477  298 ALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGP 342

MFS_SLC45_SUC

cd17313

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...

109-207

6.67e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 38.76 E-value: 6.67e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 109 MVLAPVFGYLGDRYN------RKYLMCGGIA---FWSLV----TLGSSFIPGEHFW-LLLLTRGLVGVGEASYSTIAPT- 173
Cdd:cd17313   48 LFVQPLVGSLSDRCNsrigrrRPFILVGAPLaalGLILIpnaaDIGLALGDGPRTWaLVLFVLGIVLLDFAMNVCQGPVr 127

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 215490102 174 -LIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGS 207
Cdd:cd17313  128 aLLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGA 162

PTR2

pfam00854

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...

136-219

7.72e-03

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.

Pssm-ID: 425909 [Multi-domain] Cd Length: 392 Bit Score: 38.45 E-value: 7.72e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  136 SLVTLGS--SFIPGEHFWLLLLTRGLVGVGeasYSTIAP---TLIADLFVADQ---RSRMLSIFYFAIPVGSGLGYIAGS 207
Cdd:pfam00854  16 ILLALSAipSLRPPVHVALFFIGLALIALG---TGGIKPnvsSFGGDQFEETDprrRSRFFSIFYFSINAGSLISTIITP 92

                          90
                  ....*....|..
gi 215490102  208 KVKDMAGdWHWA 219
Cdd:pfam00854  93 YLQQNYG-YPLG 103

MFS_YcxA_like

cd17355

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...

59-393

9.02e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.41 E-value: 9.02e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102  59 ALIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLV 138
Cdd:cd17355    2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 139 TLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQ-RSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWH 217
Cdd:cd17355   82 LVLLALAT--SLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERrRGLALGILTAGGGLGSLVFLPLGAALIEAFG-WR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 218 WALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPlnPTSWWADLRALARN-----LIFGLITCLTGVLGVGLGVEIS 292
Cdd:cd17355  159 TALLVLALLALLVLVPVLLLLRRRPADLALRAYDDAS--PASPGSTLKEALRSasfwlLALAFFLCGFAVVGLIVHLVPY 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490102 293 RRLRHSNPRADPLVCAT------------GLLG---SAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYV 357
Cdd:cd17355  237 LADRGISPAAAAVALALiglfnivgrllsGWLGdrySPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGAT 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 215490102 358 VIPTRRSTAEAFQ----------IVLSHLLGDAGSPYLIGLISDRL 393
Cdd:cd17355  317 VPLTAALAARYFGarsygtlfglVFAPHQLGSALGPWLGGLLYDRT 362

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01