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Conserved domains on  [gi|218505783|ref|NP_001136239|]
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protocadherin-15 isoform CD1-8 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECD super family cl39769
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 31-140 5.69e-60

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


The actual alignment was detected with superfamily member pfam18432:

Pssm-ID: 408229  Cd Length: 110  Bit Score: 201.09  E-value: 5.69e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    31 DCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMN 110
Cdd:pfam18432    1 DCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMN 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 218505783   111 IHSIVVQVQCINKKVGTIIYHEVRIVVRDR 140
Cdd:pfam18432   81 IHSIVVQVQCVNKKVGTVIYHEVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 584-676 9.53e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 9.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  584 YSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 659
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                          90
                  ....*....|....*..
gi 218505783  660 GTSTATVNIVVTDVNDN 676
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 685-778 2.35e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 2.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  685 PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH 760
Cdd:cd11304     1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505783  761 PRHSTLTLAIKVLDIDDN 778
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 786-884 9.55e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 9.55e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  786 TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFD 863
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|.
gi 218505783  864 IYGTMPPGIATVTVIVKDMND 884
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1008-1103 1.50e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 1.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783 1008 VSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLR 1083
Cdd:cd11304     6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                          90       100
                  ....*....|....*....|
gi 218505783 1084 VPSKSNTAKVYIEIQDENNH 1103
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 476-572 1.80e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 1.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  476 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 554
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505783  555 aeRRNSICTVYIEVLPPN 572
Cdd:cd11304    81 --PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 893-990 5.75e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 5.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  893 IYKGMVAPDAVKGTPITTVYAEDADPPglPASRVRYRVDDVQfpyPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 972
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 218505783  973 DDGEPVMSSSATVKILVL 990
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-468 2.66e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 2.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  362 SYQGYILESAPVGATIsdslnltspLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGItryLTLLQPVDREEQQTY 440
Cdd:cd11304     1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGE---ITTAKPLDREEQSSY 68

                          90       100       110
                  ....*....|....*....|....*....|
gi 218505783  441 TFSITAFDGVQE--SEPVIVNIQVMDANDN 468
Cdd:cd11304    69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1112-1206 2.42e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783 1112 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1191
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90
                  ....*....|....*
gi 218505783 1192 GKGLSGKADVLVSVV 1206
Cdd:cd11304    79 GPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 268-356 1.78e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 1.78e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    268 QAIDQDRNiqppsDRPGILYSILvgtPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIE 347
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 218505783    348 ILDENNQSP 356
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 151-197 2.47e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.92  E-value: 2.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 218505783  151 SYYATVNELTPVGTTIFTgFSgdngATDIDDGPNGQIEYVIQYNPDD 197
Cdd:cd11304     1 SYEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSIVSGNED 42
 
Name Accession Description Interval E-value
ECD pfam18432
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 31-140 5.69e-60

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


Pssm-ID: 408229  Cd Length: 110  Bit Score: 201.09  E-value: 5.69e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    31 DCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMN 110
Cdd:pfam18432    1 DCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMN 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 218505783   111 IHSIVVQVQCINKKVGTIIYHEVRIVVRDR 140
Cdd:pfam18432   81 IHSIVVQVQCVNKKVGTVIYHEVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 584-676 9.53e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 9.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  584 YSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 659
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                          90
                  ....*....|....*..
gi 218505783  660 GTSTATVNIVVTDVNDN 676
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 685-778 2.35e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 2.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  685 PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH 760
Cdd:cd11304     1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505783  761 PRHSTLTLAIKVLDIDDN 778
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 786-884 9.55e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 9.55e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  786 TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFD 863
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|.
gi 218505783  864 IYGTMPPGIATVTVIVKDMND 884
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 703-780 6.61e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 6.61e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    703 KATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 779
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 218505783    780 P 780
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1008-1103 1.50e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 1.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783 1008 VSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLR 1083
Cdd:cd11304     6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                          90       100
                  ....*....|....*....|
gi 218505783 1084 VPSKSNTAKVYIEIQDENNH 1103
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 602-678 3.66e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 3.66e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    602 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNA 677
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDgGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 218505783    678 P 678
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
691-773 1.00e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 1.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   691 VEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 765
Cdd:pfam00028    5 VPENApvGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 218505783   766 LTLAIKVL 773
Cdd:pfam00028   85 ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 476-572 1.80e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 1.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  476 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 554
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505783  555 aeRRNSICTVYIEVLPPN 572
Cdd:cd11304    81 --PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1027-1105 2.68e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 2.68e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218505783   1027 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLRVPSKSNTAKVYIEIQDENNHPP 1105
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA-------TDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
584-671 6.71e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 6.71e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   584 YSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 659
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPP 80

                           90
                   ....*....|..
gi 218505783   660 GTSTATVNIVVT 671
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 893-990 5.75e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 5.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  893 IYKGMVAPDAVKGTPITTVYAEDADPPglPASRVRYRVDDVQfpyPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 972
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 218505783  973 DDGEPVMSSSATVKILVL 990
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
1008-1098 3.60e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 3.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  1008 VSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLR 1083
Cdd:pfam00028    5 VPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA-------TDSG 77

                           90
                   ....*....|....*
gi 218505783  1084 VPSKSNTAKVYIEIQ 1098
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
787-879 6.45e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 6.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   787 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDI 864
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRE----SIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 218505783   865 YGTMPPGIATVTVIV 879
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-468 2.66e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 2.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  362 SYQGYILESAPVGATIsdslnltspLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGItryLTLLQPVDREEQQTY 440
Cdd:cd11304     1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGE---ITTAKPLDREEQSSY 68

                          90       100       110
                  ....*....|....*....|....*....|
gi 218505783  441 TFSITAFDGVQE--SEPVIVNIQVMDANDN 468
Cdd:cd11304    69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 806-887 3.17e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 3.17e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    806 AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 883
Cdd:smart00112    2 ATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 218505783    884 DYPP 887
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1112-1206 2.42e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783 1112 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1191
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90
                  ....*....|....*
gi 218505783 1192 GKGLSGKADVLVSVV 1206
Cdd:cd11304    79 GPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
901-990 2.71e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 2.71e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   901 DAVKGTPITTVYAEDADPPglPASRVRYRVddvQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 980
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLG--PNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 218505783   981 SSATVKILVL 990
Cdd:pfam00028   83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
477-569 4.33e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 4.33e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   477 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 555
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....
gi 218505783   556 erRNSICTVYIEVL 569
Cdd:pfam00028   81 --LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-576 2.51e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 2.51e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    495 TAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPaeRRNSICTVYIEVLPPNN 573
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVND 78


                    ...
gi 218505783    574 QSP 576
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 913-990 4.78e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 4.78e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218505783    913 AEDADPPglPASRVRYRVDDvqfPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 990
Cdd:smart00112    2 ATDADSG--ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 390-470 7.22e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 7.22e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    390 VALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGItryLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDAN 466
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIdPETGE---ITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVN 77


                    ....
gi 218505783    467 DNTP 470
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
1116-1205 1.46e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  1116 VSEDARMFTSVLRVKATDKDTGNYSVMAYRliippIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1193
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYS-----ILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 218505783  1194 GLSGKADVLVSV 1205
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 268-356 1.78e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 1.78e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    268 QAIDQDRNiqppsDRPGILYSILvgtPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIE 347
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 218505783    348 ILDENNQSP 356
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
363-462 6.42e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 6.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   363 YQGYILESAPVGatisdslnlTSPLRIVALDKDIEDTKDPElHLFLNDYTS-VFTVTQtgITRYLTLLQPVDREEQQTYT 441
Cdd:pfam00028    1 YSASVPENAPVG---------TEVLTVTATDPDLGPNGRIF-YSILGGGPGgNFRIDP--DTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|...
gi 218505783   442 FSITAFDGVQE--SEPVIVNIQV 462
Cdd:pfam00028   69 LTVEATDSGGPplSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1130-1210 1.74e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 1.74e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   1130 KATDKDTGNYSVMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1209
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN---DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    .
gi 218505783   1210 D 1210
Cdd:smart00112   78 D 78
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 438-708 1.58e-04

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 46.96  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  438 QTYTFSITAFDGVQESEPVIVNIQVmdANDNTPTFPEISYDVYVytdmRPGDSV-IQLTAVDADegsNGEITYE-ILVGA 515
Cdd:NF038112 1252 TVLTFQLVVSDGTKTSAPDTVTVLV--RNVNRAPVAVAGAPATV----DERSTVtLDGSGTDAD---GDALTYAwTQTSG 1322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  516 QGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAerrnsicTVYIEVLPPNnqsppRFPQLMYSLEISEAMRv 594
Cdd:NF038112 1323 PAVTLTGATTATATfTAPEVTADTQLTFTLTVSDGTASATD-------TVTVTVRNVN-----RAPVANAGADQTVDER- 1389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  595 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTL-GKALDRESTDRYILIITAsdgrpDGTSTATVNIVVTDV 673
Cdd:NF038112 1390 STVTLSGSATDPDGDALTYAWTQTAGPTVTLTGADTATASFtAPEVAADTELTFQLTVSA-----DGQASADVTVTVTVR 1464

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 218505783  674 NDN-APVFDpylPRNLSVVEEEANAFVgQVKATDPD 708
Cdd:NF038112 1465 NVNrAPVAH---AGESITVDEGSTVTL-DASATDPD 1496
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 151-197 2.47e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.92  E-value: 2.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 218505783  151 SYYATVNELTPVGTTIFTgFSgdngATDIDDGPNGQIEYVIQYNPDD 197
Cdd:cd11304     1 SYEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSIVSGNED 42
 
Name Accession Description Interval E-value
ECD pfam18432
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 31-140 5.69e-60

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


Pssm-ID: 408229  Cd Length: 110  Bit Score: 201.09  E-value: 5.69e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    31 DCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMN 110
Cdd:pfam18432    1 DCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMN 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 218505783   111 IHSIVVQVQCINKKVGTIIYHEVRIVVRDR 140
Cdd:pfam18432   81 IHSIVVQVQCVNKKVGTVIYHEVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 584-676 9.53e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 9.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  584 YSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 659
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                          90
                  ....*....|....*..
gi 218505783  660 GTSTATVNIVVTDVNDN 676
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 685-778 2.35e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 2.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  685 PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH 760
Cdd:cd11304     1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505783  761 PRHSTLTLAIKVLDIDDN 778
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 786-884 9.55e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 9.55e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  786 TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFD 863
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|.
gi 218505783  864 IYGTMPPGIATVTVIVKDMND 884
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 703-780 6.61e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 6.61e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    703 KATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 779
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 218505783    780 P 780
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1008-1103 1.50e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 1.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783 1008 VSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLR 1083
Cdd:cd11304     6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                          90       100
                  ....*....|....*....|
gi 218505783 1084 VPSKSNTAKVYIEIQDENNH 1103
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 602-678 3.66e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 3.66e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    602 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNA 677
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDgGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 218505783    678 P 678
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
691-773 1.00e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 1.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   691 VEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 765
Cdd:pfam00028    5 VPENApvGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 218505783   766 LTLAIKVL 773
Cdd:pfam00028   85 ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 476-572 1.80e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 1.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  476 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 554
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505783  555 aeRRNSICTVYIEVLPPN 572
Cdd:cd11304    81 --PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1027-1105 2.68e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 2.68e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218505783   1027 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLRVPSKSNTAKVYIEIQDENNHPP 1105
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA-------TDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
584-671 6.71e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 6.71e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   584 YSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 659
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPP 80

                           90
                   ....*....|..
gi 218505783   660 GTSTATVNIVVT 671
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 893-990 5.75e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 5.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  893 IYKGMVAPDAVKGTPITTVYAEDADPPglPASRVRYRVDDVQfpyPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 972
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 218505783  973 DDGEPVMSSSATVKILVL 990
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
1008-1098 3.60e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 3.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  1008 VSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLR 1083
Cdd:pfam00028    5 VPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA-------TDSG 77

                           90
                   ....*....|....*
gi 218505783  1084 VPSKSNTAKVYIEIQ 1098
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
787-879 6.45e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 6.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   787 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDI 864
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRE----SIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 218505783   865 YGTMPPGIATVTVIV 879
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-468 2.66e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 2.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  362 SYQGYILESAPVGATIsdslnltspLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGItryLTLLQPVDREEQQTY 440
Cdd:cd11304     1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGE---ITTAKPLDREEQSSY 68

                          90       100       110
                  ....*....|....*....|....*....|
gi 218505783  441 TFSITAFDGVQE--SEPVIVNIQVMDANDN 468
Cdd:cd11304    69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 806-887 3.17e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 3.17e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    806 AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 883
Cdd:smart00112    2 ATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 218505783    884 DYPP 887
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1112-1206 2.42e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783 1112 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1191
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90
                  ....*....|....*
gi 218505783 1192 GKGLSGKADVLVSVV 1206
Cdd:cd11304    79 GPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
901-990 2.71e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 2.71e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   901 DAVKGTPITTVYAEDADPPglPASRVRYRVddvQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 980
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLG--PNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 218505783   981 SSATVKILVL 990
Cdd:pfam00028   83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
477-569 4.33e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 4.33e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   477 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 555
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....
gi 218505783   556 erRNSICTVYIEVL 569
Cdd:pfam00028   81 --LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-576 2.51e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 2.51e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    495 TAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPaeRRNSICTVYIEVLPPNN 573
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVND 78


                    ...
gi 218505783    574 QSP 576
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 913-990 4.78e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 4.78e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218505783    913 AEDADPPglPASRVRYRVDDvqfPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 990
Cdd:smart00112    2 ATDADSG--ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 390-470 7.22e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 7.22e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    390 VALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGItryLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDAN 466
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIdPETGE---ITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVN 77


                    ....
gi 218505783    467 DNTP 470
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
1116-1205 1.46e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  1116 VSEDARMFTSVLRVKATDKDTGNYSVMAYRliippIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1193
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYS-----ILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 218505783  1194 GLSGKADVLVSV 1205
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 268-356 1.78e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 1.78e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783    268 QAIDQDRNiqppsDRPGILYSILvgtPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIE 347
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 218505783    348 ILDENNQSP 356
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
363-462 6.42e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 6.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   363 YQGYILESAPVGatisdslnlTSPLRIVALDKDIEDTKDPElHLFLNDYTS-VFTVTQtgITRYLTLLQPVDREEQQTYT 441
Cdd:pfam00028    1 YSASVPENAPVG---------TEVLTVTATDPDLGPNGRIF-YSILGGGPGgNFRIDP--DTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|...
gi 218505783   442 FSITAFDGVQE--SEPVIVNIQV 462
Cdd:pfam00028   69 LTVEATDSGGPplSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1130-1210 1.74e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 1.74e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783   1130 KATDKDTGNYSVMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1209
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN---DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    .
gi 218505783   1210 D 1210
Cdd:smart00112   78 D 78
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 438-708 1.58e-04

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 46.96  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  438 QTYTFSITAFDGVQESEPVIVNIQVmdANDNTPTFPEISYDVYVytdmRPGDSV-IQLTAVDADegsNGEITYE-ILVGA 515
Cdd:NF038112 1252 TVLTFQLVVSDGTKTSAPDTVTVLV--RNVNRAPVAVAGAPATV----DERSTVtLDGSGTDAD---GDALTYAwTQTSG 1322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  516 QGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAerrnsicTVYIEVLPPNnqsppRFPQLMYSLEISEAMRv 594
Cdd:NF038112 1323 PAVTLTGATTATATfTAPEVTADTQLTFTLTVSDGTASATD-------TVTVTVRNVN-----RAPVANAGADQTVDER- 1389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505783  595 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTL-GKALDRESTDRYILIITAsdgrpDGTSTATVNIVVTDV 673
Cdd:NF038112 1390 STVTLSGSATDPDGDALTYAWTQTAGPTVTLTGADTATASFtAPEVAADTELTFQLTVSA-----DGQASADVTVTVTVR 1464

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 218505783  674 NDN-APVFDpylPRNLSVVEEEANAFVgQVKATDPD 708
Cdd:NF038112 1465 NVNrAPVAH---AGESITVDEGSTVTL-DASATDPD 1496
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 151-197 2.47e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.92  E-value: 2.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 218505783  151 SYYATVNELTPVGTTIFTgFSgdngATDIDDGPNGQIEYVIQYNPDD 197
Cdd:cd11304     1 SYEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSIVSGNED 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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