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Conserved domains on  [gi|291084494|ref|NP_001137455|]
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chordin-like protein 1 isoform 4 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CHRDL_1_2_C pfam19548
Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 ...
 259-378 2.77e-85

Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 and 2. These proteins can bind BMPs family ligands and inhibit its activity by blocking their interaction with their receptors. They are involved in myoblast and osteoblast differentiation and maturation.


:

Pssm-ID: 437380  Cd Length: 120  Bit Score: 254.35  E-value: 2.77e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084494  259 NKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQW 338
Cdd:pfam19548   1 SKEYFCGEETMPVYESVFMEEGETTRKIALETERPPQVEVHVWTIRKGILHHFHIEKISKREFEELGHFKLLTRTTLSQW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 291084494  339 KIFTEGEAQISQMCSSRVCRTELEDLVKVLYLERSEKGHC 378
Cdd:pfam19548  81 KIFSEGEAQISQMCSSRVCRTELEDLVKVLYLEKSEKGHC 120
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 181-243 1.17e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 45.11  E-value: 1.17e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291084494  181 CVSNGKTYSHGESWHPNLrafgiveCVLCTCNVTKQECKKIHCPnRYPCKYPQKI--DGKCCKVC 243
Cdd:pfam00093   1 CVQNGVVYENGETWKPDL-------CTICTCDDGKVLCDKIICP-PLDCPNPRLEipPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 37-99 2.48e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 41.64  E-value: 2.48e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291084494   37 CMFQDKKYRVGERWHPYLepyglvyCVNCICsENGNVLCSRVRCPNVHCLSPVHIPHL--CCPRC 99
Cdd:pfam00093   1 CVQNGVVYENGETWKPDL-------CTICTC-DDGKVLCDKIICPPLDCPNPRLEIPPgeCCPVC 57
 
Name Accession Description Interval E-value
CHRDL_1_2_C pfam19548
Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 ...
 259-378 2.77e-85

Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 and 2. These proteins can bind BMPs family ligands and inhibit its activity by blocking their interaction with their receptors. They are involved in myoblast and osteoblast differentiation and maturation.


Pssm-ID: 437380  Cd Length: 120  Bit Score: 254.35  E-value: 2.77e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084494  259 NKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQW 338
Cdd:pfam19548   1 SKEYFCGEETMPVYESVFMEEGETTRKIALETERPPQVEVHVWTIRKGILHHFHIEKISKREFEELGHFKLLTRTTLSQW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 291084494  339 KIFTEGEAQISQMCSSRVCRTELEDLVKVLYLERSEKGHC 378
Cdd:pfam19548  81 KIFSEGEAQISQMCSSRVCRTELEDLVKVLYLEKSEKGHC 120
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 181-243 1.17e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.11  E-value: 1.17e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291084494  181 CVSNGKTYSHGESWHPNLrafgiveCVLCTCNVTKQECKKIHCPnRYPCKYPQKI--DGKCCKVC 243
Cdd:pfam00093   1 CVQNGVVYENGETWKPDL-------CTICTCDDGKVLCDKIICP-PLDCPNPRLEipPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
181-243 5.95e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 43.27  E-value: 5.95e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 291084494   181 CVSNGKTYSHGESWHPNlrafgivECVLCTCNVTKQE-CKKIHCPNRYPCKYPQ--KIDGKCCKVC 243
Cdd:smart00214   1 CVHNGRVYNDGETWKPD-------PCQICTCLDGTTVlCDPVECPPPPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 37-99 2.48e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 41.64  E-value: 2.48e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291084494   37 CMFQDKKYRVGERWHPYLepyglvyCVNCICsENGNVLCSRVRCPNVHCLSPVHIPHL--CCPRC 99
Cdd:pfam00093   1 CVQNGVVYENGETWKPDL-------CTICTC-DDGKVLCDKIICPPLDCPNPRLEIPPgeCCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
37-99 8.06e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 34.41  E-value: 8.06e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 291084494    37 CMFQDKKYRVGERWHPYlepyglvYCVNCICSENGNVLCSRVRCP-NVHCLSPVHIPHL--CCPRC 99
Cdd:smart00214   1 CVHNGRVYNDGETWKPD-------PCQICTCLDGTTVLCDPVECPpPPDCPNPERVKPPgeCCPRC 59
 
Name Accession Description Interval E-value
CHRDL_1_2_C pfam19548
Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 ...
 259-378 2.77e-85

Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 and 2. These proteins can bind BMPs family ligands and inhibit its activity by blocking their interaction with their receptors. They are involved in myoblast and osteoblast differentiation and maturation.


Pssm-ID: 437380  Cd Length: 120  Bit Score: 254.35  E-value: 2.77e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084494  259 NKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQW 338
Cdd:pfam19548   1 SKEYFCGEETMPVYESVFMEEGETTRKIALETERPPQVEVHVWTIRKGILHHFHIEKISKREFEELGHFKLLTRTTLSQW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 291084494  339 KIFTEGEAQISQMCSSRVCRTELEDLVKVLYLERSEKGHC 378
Cdd:pfam19548  81 KIFSEGEAQISQMCSSRVCRTELEDLVKVLYLEKSEKGHC 120
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 181-243 1.17e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.11  E-value: 1.17e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291084494  181 CVSNGKTYSHGESWHPNLrafgiveCVLCTCNVTKQECKKIHCPnRYPCKYPQKI--DGKCCKVC 243
Cdd:pfam00093   1 CVQNGVVYENGETWKPDL-------CTICTCDDGKVLCDKIICP-PLDCPNPRLEipPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
181-243 5.95e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 43.27  E-value: 5.95e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 291084494   181 CVSNGKTYSHGESWHPNlrafgivECVLCTCNVTKQE-CKKIHCPNRYPCKYPQ--KIDGKCCKVC 243
Cdd:smart00214   1 CVHNGRVYNDGETWKPD-------PCQICTCLDGTTVlCDPVECPPPPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 37-99 2.48e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 41.64  E-value: 2.48e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291084494   37 CMFQDKKYRVGERWHPYLepyglvyCVNCICsENGNVLCSRVRCPNVHCLSPVHIPHL--CCPRC 99
Cdd:pfam00093   1 CVQNGVVYENGETWKPDL-------CTICTC-DDGKVLCDKIICPPLDCPNPRLEIPPgeCCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 62-99 1.36e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.45  E-value: 1.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 291084494   62 CVNCIC--SENGNVLCSRV--RCPNVHCLSPVHIPHLCCPRC 99
Cdd:pfam14828 194 PSGCGCgnDENLERICANVlqRCPPPHCLSPLRPEGHCCDVC 235
VWC smart00214
von Willebrand factor (vWF) type C domain;
37-99 8.06e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 34.41  E-value: 8.06e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 291084494    37 CMFQDKKYRVGERWHPYlepyglvYCVNCICSENGNVLCSRVRCP-NVHCLSPVHIPHL--CCPRC 99
Cdd:smart00214   1 CVHNGRVYNDGETWKPD-------PCQICTCLDGTTVLCDPVECPpPPDCPNPERVKPPgeCCPRC 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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