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Conserved domains on  [gi|320543660|ref|NP_001137617|]
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pou domain motif 3, isoform C [Drosophila melanogaster]

Protein Classification

POU family transcription factor( domain architecture ID 11036637)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pou super family cl22952
Pou domain - N-terminal to homeobox domain;
1108-1199 3.64e-29

Pou domain - N-terminal to homeobox domain;


The actual alignment was detected with superfamily member smart00352:

Pssm-ID: 473999  Cd Length: 75  Bit Score: 111.38  E-value: 3.64e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543660   1108 DGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSalaaqmyaaqlstqqqnmFEKLDITPKSAQKI 1187
Cdd:smart00352    2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICR------------------FEALQLSFKNMCKL 63

                            90
                    ....*....|..
gi 320543660   1188 KPVLERWMKEAE 1199
Cdd:smart00352   64 KPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
1225-1281 2.83e-18

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 2.83e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 320543660  1225 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKN 1281
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
1108-1199 3.64e-29

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 111.38  E-value: 3.64e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543660   1108 DGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSalaaqmyaaqlstqqqnmFEKLDITPKSAQKI 1187
Cdd:smart00352    2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICR------------------FEALQLSFKNMCKL 63

                            90
                    ....*....|..
gi 320543660   1188 KPVLERWMKEAE 1199
Cdd:smart00352   64 KPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
1110-1199 1.55e-28

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 109.29  E-value: 1.55e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543660  1110 IDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSalaaqmyaaqlstqqqnmFEKLDITPKSAQKIKP 1189
Cdd:pfam00157    1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICR------------------FEKLDLSLKNMCKLKP 62

                           90
                   ....*....|
gi 320543660  1190 VLERWMKEAE 1199
Cdd:pfam00157   63 LLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
1225-1281 2.83e-18

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 2.83e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 320543660  1225 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKN 1281
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1224-1280 9.04e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.67  E-value: 9.04e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 320543660   1224 KRKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1280
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1225-1282 2.15e-15

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 71.51  E-value: 2.15e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 320543660 1225 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKNT 1282
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1221-1280 2.65e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 51.67  E-value: 2.65e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543660 1221 PSKKRKRRTsfTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1280
Cdd:COG5576    50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
1108-1199 3.64e-29

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 111.38  E-value: 3.64e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543660   1108 DGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSalaaqmyaaqlstqqqnmFEKLDITPKSAQKI 1187
Cdd:smart00352    2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICR------------------FEALQLSFKNMCKL 63

                            90
                    ....*....|..
gi 320543660   1188 KPVLERWMKEAE 1199
Cdd:smart00352   64 KPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
1110-1199 1.55e-28

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 109.29  E-value: 1.55e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543660  1110 IDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSalaaqmyaaqlstqqqnmFEKLDITPKSAQKIKP 1189
Cdd:pfam00157    1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICR------------------FEKLDLSLKNMCKLKP 62

                           90
                   ....*....|
gi 320543660  1190 VLERWMKEAE 1199
Cdd:pfam00157   63 LLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
1225-1281 2.83e-18

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 2.83e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 320543660  1225 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKN 1281
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1224-1280 9.04e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.67  E-value: 9.04e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 320543660   1224 KRKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1280
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1225-1282 2.15e-15

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 71.51  E-value: 2.15e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 320543660 1225 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKNT 1282
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1221-1280 2.65e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 51.67  E-value: 2.65e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543660 1221 PSKKRKRRTsfTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1280
Cdd:COG5576    50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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