NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|221330086|ref|NP_001137625|]
View 

Calmodulin-binding transcription activator, isoform B [Drosophila melanogaster]

Protein Classification

calmodulin-binding transcription activator( domain architecture ID 12224848)

calmodulin-binding transcription activator may act as a tumor suppressor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 422-538 4.45e-71

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


:

Pssm-ID: 198144  Cd Length: 118  Bit Score: 233.45  E-value: 4.45e-71
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086    422 FPSQRHRWNTNEEIAAILISFDKHGEWQSKEVRTRPKSGSLLLYSRKKVRY-RRDGYCWKKRKDGKTTREDHMKLKVQGT 500
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 221330086    501 ECIYGCYVHSAILPTFHRRCYWLLQNPDIVLVHYLNVP 538
Cdd:smart01076   81 ECLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1410-1500 1.68e-08

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.58  E-value: 1.68e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086  1410 LHLAAALGYAKLVgamlnwrsenpHIILETELDALSQDVYGFTPLAWACVRGHVEC-SLLLykwNHNALKIKTQaQQTPL 1488
Cdd:pfam12796    1 LHLAAKNGNLELV-----------KLLLENGADANLQDKNGRTALHLAAKNGHLEIvKLLL---EHADVNLKDN-GRTAL 65

                           90
                   ....*....|....*.
gi 221330086  1489 DLASMRGH----KVLL 1500
Cdd:pfam12796   66 HYAARSGHleivKLLL 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1239-1319 9.40e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 48.60  E-value: 9.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086  1239 ICDFSPEWSYTEGGVKVLVAG---PWTSSNggaYTVLFDAQPVPTQLVQEGVLRCYCPAHEAGFVTLQVACGG-FLVSNS 1314
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGsnfGTDSSD---LKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGgGISSSP 79


                   ....*
gi 221330086  1315 VMFEY 1319
Cdd:pfam01833   80 LTFTY 84
 
Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 422-538 4.45e-71

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 233.45  E-value: 4.45e-71
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086    422 FPSQRHRWNTNEEIAAILISFDKHGEWQSKEVRTRPKSGSLLLYSRKKVRY-RRDGYCWKKRKDGKTTREDHMKLKVQGT 500
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 221330086    501 ECIYGCYVHSAILPTFHRRCYWLLQNPDIVLVHYLNVP 538
Cdd:smart01076   81 ECLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 426-537 9.48e-61

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 203.65  E-value: 9.48e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086   426 RHRWNTNEEIAAILISFDKHGEWQSKEVRTRPKSGSLLLYSRKKVRY-RRDGYCWKKRKDGKTTREDHMKLKVQGTECIY 504
Cdd:pfam03859    1 KTRWLKPQEILAILLNYDPYGFCITPEPPPRPPSGSLFLFDRKKLRYfRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIH 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 221330086   505 GCYVHSAILPTFHRRCYWLLQNP-DIVLVHYLNV 537
Cdd:pfam03859   81 CYYAHSEDNPTFQRRIYWLLDSDyHIVLVHYLNV 114
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1410-1500 1.68e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.58  E-value: 1.68e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086  1410 LHLAAALGYAKLVgamlnwrsenpHIILETELDALSQDVYGFTPLAWACVRGHVEC-SLLLykwNHNALKIKTQaQQTPL 1488
Cdd:pfam12796    1 LHLAAKNGNLELV-----------KLLLENGADANLQDKNGRTALHLAAKNGHLEIvKLLL---EHADVNLKDN-GRTAL 65

                           90
                   ....*....|....*.
gi 221330086  1489 DLASMRGH----KVLL 1500
Cdd:pfam12796   66 HYAARSGHleivKLLL 81
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1405-1502 3.77e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.27  E-value: 3.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086 1405 RGMTLLHLAAALGYAKLVGAMLNwRSENPHIileteldalsQDVYGFTPLAWACVRGHVEC-SLLLykwNHNA-LKIKTQ 1482
Cdd:COG0666   119 DGETPLHLAAYNGNLEIVKLLLE-AGADVNA----------QDNDGNTPLHLAAANGNLEIvKLLL---EAGAdVNARDN 184

                          90       100
                  ....*....|....*....|....
gi 221330086 1483 AQQTPLDLASMRGH----KVLLAQ 1502
Cdd:COG0666   185 DGETPLHLAAENGHleivKLLLEA 208
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1239-1319 9.40e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 48.60  E-value: 9.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086  1239 ICDFSPEWSYTEGGVKVLVAG---PWTSSNggaYTVLFDAQPVPTQLVQEGVLRCYCPAHEAGFVTLQVACGG-FLVSNS 1314
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGsnfGTDSSD---LKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGgGISSSP 79


                   ....*
gi 221330086  1315 VMFEY 1319
Cdd:pfam01833   80 LTFTY 84
 
Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 422-538 4.45e-71

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 233.45  E-value: 4.45e-71
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086    422 FPSQRHRWNTNEEIAAILISFDKHGEWQSKEVRTRPKSGSLLLYSRKKVRY-RRDGYCWKKRKDGKTTREDHMKLKVQGT 500
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 221330086    501 ECIYGCYVHSAILPTFHRRCYWLLQNPDIVLVHYLNVP 538
Cdd:smart01076   81 ECLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 426-537 9.48e-61

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 203.65  E-value: 9.48e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086   426 RHRWNTNEEIAAILISFDKHGEWQSKEVRTRPKSGSLLLYSRKKVRY-RRDGYCWKKRKDGKTTREDHMKLKVQGTECIY 504
Cdd:pfam03859    1 KTRWLKPQEILAILLNYDPYGFCITPEPPPRPPSGSLFLFDRKKLRYfRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIH 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 221330086   505 GCYVHSAILPTFHRRCYWLLQNP-DIVLVHYLNV 537
Cdd:pfam03859   81 CYYAHSEDNPTFQRRIYWLLDSDyHIVLVHYLNV 114
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1410-1500 1.68e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.58  E-value: 1.68e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086  1410 LHLAAALGYAKLVgamlnwrsenpHIILETELDALSQDVYGFTPLAWACVRGHVEC-SLLLykwNHNALKIKTQaQQTPL 1488
Cdd:pfam12796    1 LHLAAKNGNLELV-----------KLLLENGADANLQDKNGRTALHLAAKNGHLEIvKLLL---EHADVNLKDN-GRTAL 65

                           90
                   ....*....|....*.
gi 221330086  1489 DLASMRGH----KVLL 1500
Cdd:pfam12796   66 HYAARSGHleivKLLL 81
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1405-1502 3.77e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.27  E-value: 3.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086 1405 RGMTLLHLAAALGYAKLVGAMLNwRSENPHIileteldalsQDVYGFTPLAWACVRGHVEC-SLLLykwNHNA-LKIKTQ 1482
Cdd:COG0666   119 DGETPLHLAAYNGNLEIVKLLLE-AGADVNA----------QDNDGNTPLHLAAANGNLEIvKLLL---EAGAdVNARDN 184

                          90       100
                  ....*....|....*....|....
gi 221330086 1483 AQQTPLDLASMRGH----KVLLAQ 1502
Cdd:COG0666   185 DGETPLHLAAENGHleivKLLLEA 208
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1239-1319 9.40e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 48.60  E-value: 9.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086  1239 ICDFSPEWSYTEGGVKVLVAG---PWTSSNggaYTVLFDAQPVPTQLVQEGVLRCYCPAHEAGFVTLQVACGG-FLVSNS 1314
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGsnfGTDSSD---LKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGgGISSSP 79


                   ....*
gi 221330086  1315 VMFEY 1319
Cdd:pfam01833   80 LTFTY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1406-1502 4.34e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.72  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330086 1406 GMTLLHLAAALGYAKLVgamlnwrsenpHIILETELDALSQDVYGFTPLAWACVRGHVEC-SLLLykwNHNA-LKIKTQA 1483
Cdd:COG0666    87 GNTLLHAAARNGDLEIV-----------KLLLEAGADVNARDKDGETPLHLAAYNGNLEIvKLLL---EAGAdVNAQDND 152

                          90       100
                  ....*....|....*....|...
gi 221330086 1484 QQTPLDLASMRGH----KVLLAQ 1502
Cdd:COG0666   153 GNTPLHLAAANGNleivKLLLEA 175
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1406-1471 1.94e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 1.94e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221330086  1406 GMTLLHLAAALGYAKLVGAMLNwrsenpHIILETeldalsqDVYGFTPLAWACVRGHVEC-SLLLYK 1471
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLLLE------HADVNL-------KDNGRTALHYAARSGHLEIvKLLLEK 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH