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Conserved domains on  [gi|221475185|ref|NP_001137823|]
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uncharacterized protein Dmel_CG32971, isoform B [Drosophila melanogaster]

Protein Classification

mediator of RNA polymerase II transcription subunit 22( domain architecture ID 10533081)

mediator of RNA polymerase II transcription subunit 22 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med22 pfam06179
Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several ...
 15-116 9.29e-26

Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1. The locus includes six tightly clustered housekeeping genes (Surf1-6), and the gene organization is similar in human, mouse and chicken Surfeit locus. The Med22 subunit of Mediator complex is part of the essential core head region.


:

Pssm-ID: 461845  Cd Length: 101  Bit Score: 93.41  E-value: 9.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475185   15 TQLKDNVLSMLLNFEELLKLVSPRTPGQITNDTeQELNAFEMQVRAGNFVRAGEALIKLVHDVKEYQIIYDYSNIEEEMD 94
Cdd:pfam06179   1 KRLDDDIESILDNFRELIKLAKVNDEGQRNNST-QAQEGYEMEVRAANLVRAIESLLKLTRELKELWILNDFPSLNEAIK 79

                          90       100
                  ....*....|....*....|..
gi 221475185   95 RQSEAMHAKVTEYDQTLIKMVK 116
Cdd:pfam06179  80 QREEQLDADVEELDSLLNKLRD 101
 
Name Accession Description Interval E-value
Med22 pfam06179
Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several ...
 15-116 9.29e-26

Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1. The locus includes six tightly clustered housekeeping genes (Surf1-6), and the gene organization is similar in human, mouse and chicken Surfeit locus. The Med22 subunit of Mediator complex is part of the essential core head region.


Pssm-ID: 461845  Cd Length: 101  Bit Score: 93.41  E-value: 9.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475185   15 TQLKDNVLSMLLNFEELLKLVSPRTPGQITNDTeQELNAFEMQVRAGNFVRAGEALIKLVHDVKEYQIIYDYSNIEEEMD 94
Cdd:pfam06179   1 KRLDDDIESILDNFRELIKLAKVNDEGQRNNST-QAQEGYEMEVRAANLVRAIESLLKLTRELKELWILNDFPSLNEAIK 79

                          90       100
                  ....*....|....*....|..
gi 221475185   95 RQSEAMHAKVTEYDQTLIKMVK 116
Cdd:pfam06179  80 QREEQLDADVEELDSLLNKLRD 101
 
Name Accession Description Interval E-value
Med22 pfam06179
Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several ...
 15-116 9.29e-26

Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1. The locus includes six tightly clustered housekeeping genes (Surf1-6), and the gene organization is similar in human, mouse and chicken Surfeit locus. The Med22 subunit of Mediator complex is part of the essential core head region.


Pssm-ID: 461845  Cd Length: 101  Bit Score: 93.41  E-value: 9.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475185   15 TQLKDNVLSMLLNFEELLKLVSPRTPGQITNDTeQELNAFEMQVRAGNFVRAGEALIKLVHDVKEYQIIYDYSNIEEEMD 94
Cdd:pfam06179   1 KRLDDDIESILDNFRELIKLAKVNDEGQRNNST-QAQEGYEMEVRAANLVRAIESLLKLTRELKELWILNDFPSLNEAIK 79

                          90       100
                  ....*....|....*....|..
gi 221475185   95 RQSEAMHAKVTEYDQTLIKMVK 116
Cdd:pfam06179  80 QREEQLDADVEELDSLLNKLRD 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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