|
Name |
Accession |
Description |
Interval |
E-value |
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2889-2966 |
1.60e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
:
Pssm-ID: 464783 Cd Length: 78 Bit Score: 139.28 E-value: 1.60e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221329864 2889 KEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVK 2966
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL super family |
cl18310 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1239-1544 |
7.35e-35 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
The actual alignment was detected with superfamily member cd14953:
Pssm-ID: 302697 [Multi-domain] Cd Length: 323 Bit Score: 137.66 E-value: 7.35e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1239 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQL----------SATQVSYQYYLAVSPAdGHLYI 1306
Cdd:cd14953 14 GGGGTAARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfadgggAAAQFNTPSGVAVDAA-GNLYV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1307 SDPERHqilrlvRLEKVkDPSINSDPVVGSGQRcipgdeGNCGDGGpALLARLSHPKGLAIAADRTMYIADGTN--IRAV 1384
Cdd:cd14953 93 ADTGNH------RIRKI-TPDGVVSTLAGTGTA------GFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNhrIRKI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1385 DPKGVIHTLIGhhghhnhwSPAPCS---GTlmANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTp 1458
Cdd:cd14953 159 TPDGVVTTVAG--------TGGAGYagdGP--ATAAQFNNPTGVAVDA-AGNL-YVADRGnhrIRKITPDGVVTTVAGT- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1459 lhcsnGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTgsqtcdcaigGGS 1538
Cdd:cd14953 226 -----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR---IRKITPAGVVTTVAGGGAGF----------SGD 287
|
....*.
gi 221329864 1539 NGSATN 1544
Cdd:cd14953 288 GGPATS 293
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1983-2632 |
6.63e-30 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
:
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 130.65 E-value: 6.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1983 YSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFN 2062
Cdd:COG3209 375 GGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGG 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2063 RVEGWAWGPAELKYSYDRHGLLSEITSQQDGIVSFVYNDWNLVSEIGLASQRkfvlqYDDAGGLRHVVLPSGTRHSFSMQ 2142
Cdd:COG3209 455 AGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL-----GGTTTTTAGARGLVVTTGTTLTL 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2143 TSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTER 2222
Cdd:COG3209 530 GTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTT 609
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2223 ELEY-RWDFEYAAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQ 2301
Cdd:COG3209 610 TSGYtRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGT 689
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2302 PAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLV 2381
Cdd:COG3209 690 TSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLT 769
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2382 GVEAQEP-------WGFRYDDNGNLLSLTY-RGNTIPMEYNAQDRIVK-----------FGEGQYKYDARGLVAQ----- 2437
Cdd:COG3209 770 SETTPGGvtqgtytTRYTYDALGRLTSVTYpDGETVTYTYDALGRLTSvitvgsgggtdLQDRTYTYDAAGNITSitdal 849
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2438 --NAREERFHYNTQGLLVRASKRGRfDVRYYYDHLKRLTTRKDnfGNVTQFFYTNQQRPYEVSQiyspRDGKLMSLTYDD 2515
Cdd:COG3209 850 raGTLTQTYTYDALGRLTSATDPGT-TESYTYDANGNLTSRTD--GGTTTYTYDALGRLVSVTK----PDGTTTTYTYDA 922
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2516 VGHliyaqvyrhkyyvaTDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVY 2595
Cdd:COG3209 923 LGH--------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNG-ARYY 987
|
650 660 670
....*....|....*....|....*....|....*..
gi 221329864 2596 DPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2632
Cdd:COG3209 988 DPALGRFLSPD------PIGLAGGLNLYAYVGNNPVN 1018
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
825-851 |
3.13e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
:
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.44 E-value: 3.13e-09
10 20
....*....|....*....|....*..
gi 221329864 825 NCKDNIDNDGDGMTDCSDSECCSHPAC 851
Cdd:NF033662 6 TCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
660-683 |
2.79e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 43.11 E-value: 2.79e-05
10 20
....*....|....*....|....*.
gi 221329864 660 LCSGHGTCVA--GQCYCKAGWQGEDC 683
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| RHS_core super family |
cl49306 |
RHS element core protein; |
1735-1865 |
2.82e-04 |
|
RHS element core protein;
The actual alignment was detected with superfamily member NF041261:
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 46.92 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1735 SSEIYVFNRYGQHVATKDLTSGKTRYSFlysknTSFGRLSTVTDASGnkIQFLRDYSN--VVSSIENTQDHKSEIQINGI 1812
Cdd:NF041261 535 STKQMTWSRYGQLLAFTDCSGYQTRYEY-----DRFGQMTAVHREEG--ISTYRRYDNrgQLTSVKDAQGRETRYEYNAA 607
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 221329864 1813 GIMTKLSEKGRQEIELDYDSnTGLLNSRSSGGETYIYQYDEFGRVTGMILPSG 1865
Cdd:NF041261 608 GDLTAVITPDGNRSETQYDA-WGKAVSTTQGGLTRSMEYDAAGRITTLTNENG 659
|
|
| C_rich_MXAN6577 super family |
cl49352 |
MXAN_6577-like cysteine-rich domain; |
661-772 |
5.73e-04 |
|
MXAN_6577-like cysteine-rich domain;
The actual alignment was detected with superfamily member NF041328:
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 42.82 E-value: 5.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 661 CSGHGTCVAGQCYCKAGwqGEDCGtidqqvyqclpgcsehgtydletGQCVCERhwTGPD-CSQavCSLDCGRNGVCESG 739
Cdd:NF041328 49 CGAGQTCVAGACGCGPG--TVACG-----------------------GACVDTA--SDPAhCGA--CGAACAPGQVCEGG 99
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 221329864 740 KCR--CNSGWT--GNLC-----DQL---PCDSRCSEHGQCKNGTC 772
Cdd:NF041328 100 ACReaCSEGLTrcGGACvdlatDPLhcgACGVACDPGESCRGGAC 144
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
563-586 |
8.63e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 8.63e-04
10 20
....*....|....*....|....*.
gi 221329864 563 DCSGRGSCYL--GKCDCIDGYQGVDC 586
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
629-651 |
1.87e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.87e-03
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
789-818 |
3.58e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
:
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.58e-03
10 20 30
....*....|....*....|....*....|
gi 221329864 789 ENGCSRHGQCTLENGEYRCDCIEGWAGRDC 818
Cdd:cd00054 8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2889-2966 |
1.60e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 139.28 E-value: 1.60e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221329864 2889 KEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVK 2966
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1239-1544 |
7.35e-35 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 137.66 E-value: 7.35e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1239 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQL----------SATQVSYQYYLAVSPAdGHLYI 1306
Cdd:cd14953 14 GGGGTAARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfadgggAAAQFNTPSGVAVDAA-GNLYV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1307 SDPERHqilrlvRLEKVkDPSINSDPVVGSGQRcipgdeGNCGDGGpALLARLSHPKGLAIAADRTMYIADGTN--IRAV 1384
Cdd:cd14953 93 ADTGNH------RIRKI-TPDGVVSTLAGTGTA------GFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNhrIRKI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1385 DPKGVIHTLIGhhghhnhwSPAPCS---GTlmANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTp 1458
Cdd:cd14953 159 TPDGVVTTVAG--------TGGAGYagdGP--ATAAQFNNPTGVAVDA-AGNL-YVADRGnhrIRKITPDGVVTTVAGT- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1459 lhcsnGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTgsqtcdcaigGGS 1538
Cdd:cd14953 226 -----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR---IRKITPAGVVTTVAGGGAGF----------SGD 287
|
....*.
gi 221329864 1539 NGSATN 1544
Cdd:cd14953 288 GGPATS 293
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1983-2632 |
6.63e-30 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 130.65 E-value: 6.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1983 YSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFN 2062
Cdd:COG3209 375 GGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGG 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2063 RVEGWAWGPAELKYSYDRHGLLSEITSQQDGIVSFVYNDWNLVSEIGLASQRkfvlqYDDAGGLRHVVLPSGTRHSFSMQ 2142
Cdd:COG3209 455 AGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL-----GGTTTTTAGARGLVVTTGTTLTL 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2143 TSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTER 2222
Cdd:COG3209 530 GTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTT 609
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2223 ELEY-RWDFEYAAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQ 2301
Cdd:COG3209 610 TSGYtRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGT 689
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2302 PAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLV 2381
Cdd:COG3209 690 TSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLT 769
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2382 GVEAQEP-------WGFRYDDNGNLLSLTY-RGNTIPMEYNAQDRIVK-----------FGEGQYKYDARGLVAQ----- 2437
Cdd:COG3209 770 SETTPGGvtqgtytTRYTYDALGRLTSVTYpDGETVTYTYDALGRLTSvitvgsgggtdLQDRTYTYDAAGNITSitdal 849
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2438 --NAREERFHYNTQGLLVRASKRGRfDVRYYYDHLKRLTTRKDnfGNVTQFFYTNQQRPYEVSQiyspRDGKLMSLTYDD 2515
Cdd:COG3209 850 raGTLTQTYTYDALGRLTSATDPGT-TESYTYDANGNLTSRTD--GGTTTYTYDALGRLVSVTK----PDGTTTTYTYDA 922
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2516 VGHliyaqvyrhkyyvaTDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVY 2595
Cdd:COG3209 923 LGH--------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNG-ARYY 987
|
650 660 670
....*....|....*....|....*....|....*..
gi 221329864 2596 DPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2632
Cdd:COG3209 988 DPALGRFLSPD------PIGLAGGLNLYAYVGNNPVN 1018
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2067-2519 |
2.33e-14 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 80.05 E-value: 2.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2067 WAWGPA-ELKYSYDRHGllseitSQqdgIVSFVYNDWNLVSEIG--LASQRKFVLQYDDAGGLRHVVLPSGTRHSFSMQT 2143
Cdd:NF041261 322 YTYTEAgELLAVYDRSN------TQ---VRAFTYDAQHPGRMVAhrYAGRPEMCYRYDDTGRVTEQLNPAGLSYRYQYEQ 392
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2144 SigfiRCTYTPPGSTRAYLqhYSHAGALLQTILP---GDGARIVYRYNAAGQLTEVVHGDGR-SEFQYNEATGMPSTVSH 2219
Cdd:NF041261 393 D----RITITDSLNRREVL--HTEGEGGLKRVVKkehADGSVTRSGYDAAGRLTAQTDAAGRrTEYSLNVVSGDITDITT 466
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2220 TE-RELEYRWDfeyaagllaeERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGgqslPTQAFAYD-PRTGRPSLIG-- 2295
Cdd:NF041261 467 PDgRETKFYYN----------DGNQLTSVTSPDGLESRREYDEPGRLVSETSRSG----ETTRYRYDdPHSELPATTTda 532
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2296 -----QFRFSQPAQnQTQLHDGTASFTRTVDGRFQTQrmaLAIHRLEVFRMEFSYGVHGRISQTRtytrnmavNSYTNVK 2370
Cdd:NF041261 533 tgstkQMTWSRYGQ-LLAFTDCSGYQTRYEYDRFGQM---TAVHREEGISTYRRYDNRGQLTSVK--------DAQGRET 600
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2371 NYTWDCDGQLVGVEAqePWGFR----YDDNGNLLSLTYRGNTIPMEYNAQDRIVKF-----GEGQYKYDARGLVAQ---- 2437
Cdd:NF041261 601 RYEYNAAGDLTAVIT--PDGNRsetqYDAWGKAVSTTQGGLTRSMEYDAAGRITTLtnengSHSTFLYDALDRLVQqrgf 678
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2438 NAREERFHYNTQGLLVRASKRGrFDVRYYYDHLKRLTTRKDNFGNVTQFFYTNQQRPYEVSQIyspRDGKLMSL--TYDD 2515
Cdd:NF041261 679 DGRTQRYHYDLTGKLTQSEDEG-LVTLWHYDESDRITHRTVNGEPAEQWQYDEHGWLTDISHL---SEGHRVAVhyGYDD 754
|
....
gi 221329864 2516 VGHL 2519
Cdd:NF041261 755 KGRL 758
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1244-1519 |
1.02e-11 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 68.12 E-value: 1.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1244 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSATQvSYQYYLAVSPaDGHLYISDPERHQILRLvrle 1321
Cdd:COG4257 55 LGGGSGPHGIAVDPDGNLWFTDNgnNRIGRIDPKTGEITTFALPGGG-SNPHGIAFDP-DGNLWFTDQGGNRIGRL---- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1322 kvkdpsinsDPVVGSgqrcIPGDEGNCGDGGPAllarlshpkGLAIAADRTMYIAD-GTN-IRAVDPK-GVIHTLighhg 1398
Cdd:COG4257 129 ---------DPATGE----VTEFPLPTGGAGPY---------GIAVDPDGNLWVTDfGANaIGRIDPDtGTLTEY----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1399 hhnhwspapcsgtlmANQAQLQWPTGLALSPlDGSLHFIDdrlvlrltsdmkirvvagtplhcSNGGQDGRVN-KTGADN 1477
Cdd:COG4257 182 ---------------ALPTPGAGPRGLAVDP-DGNLWVAD-----------------------TGSGRIGRFDpKTGTVT 222
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 221329864 1478 VLGTVL------AMAFSPFGNLYIADSDSrrvNSIRVVDTAGNMRYFA 1519
Cdd:COG4257 223 EYPLPGggarpyGVAVDGDGRVWFAESGA---NRIVRFDPDTELTEYV 267
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1840-2477 |
1.20e-11 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 71.19 E-value: 1.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1840 RSSGGETYIYQYDEFGRVTGMILPSGeiVRITSQLADSQgLTVyvhasVESLFSRERIAGEANellvlGGVRSTFLKRgq 1919
Cdd:NF041261 358 RYAGRPEMCYRYDDTGRVTEQLNPAG--LSYRYQYEQDR-ITI-----TDSLNRREVLHTEGE-----GGLKRVVKKE-- 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1920 aHADAELKANntlvihgdngvvvEASAVARhplLEAalpveaemlamwshQSVTMGEGLTNSMYSVYSLVGDVRNPQQTL 1999
Cdd:NF041261 423 -HADGSVTRS-------------GYDAAGR---LTA--------------QTDAAGRRTEYSLNVVSGDITDITTPDGRE 471
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2000 NREIWVNQSRVIGV----------EFDQfTNRETFYDARRTPILIVAYD--QSGLPKSYYPTNGYPVNITYDRFNRVEGW 2067
Cdd:NF041261 472 TKFYYNDGNQLTSVtspdglesrrEYDE-PGRLVSETSRSGETTRYRYDdpHSELPATTTDATGSTKQMTWSRYGQLLAF 550
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2068 A-WGPAELKYSYDRHGLLSEItSQQDGIVSF-VYNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVLPSGTRhSFSMQTSI 2145
Cdd:NF041261 551 TdCSGYQTRYEYDRFGQMTAV-HREEGISTYrRYDNRGQLTSVKDAQGRETRYEYNAAGDLTAVITPDGNR-SETQYDAW 628
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2146 GFIRCTyTPPGSTRAylQHYSHAGALLqTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGmpsTVSHTERE-L 2224
Cdd:NF041261 629 GKAVST-TQGGLTRS--MEYDAAGRIT-TLTNENGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTG---KLTQSEDEgL 701
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2225 EYRWDFEyaagllAEERIDYVAKTGLSNAKFSYE---------YDSQLRVVAL------QGRIGGQSLPTQafayDPRTG 2289
Cdd:NF041261 702 VTLWHYD------ESDRITHRTVNGEPAEQWQYDehgwltdisHLSEGHRVAVhygyddKGRLTGERQTVE----NPETG 771
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2290 RpsLIGQFR----FSQPAQNQTQLHDGTASFTRTVDGRFQTQRMALA-----------IHRlEVFRMEFSYGVHGRISQT 2354
Cdd:NF041261 772 E--LLWQHEtghaYNEQGLANRVTPDSLPPVEWLTYGSGYLAGMKLGgtplveytrdrLHR-ETVRSFGGAGSNAAYELT 848
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2355 RTYT-----RNMAVNSYTNVKNYTWDCDGQLVGVEA-QEPWGFRYDDNGNLLS-------LTYR--------GNTIP--- 2410
Cdd:NF041261 849 TAYTpagqlQSQHLNSLVYDRDYTWNDNGDLVRISGpRQTREYGYSATGRLTGvhttaanLDIRipyatdpaGNRLPdpe 928
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2411 ------MEYNAQDRIVKFGEGQYKYDARGLVAQ-------------NAREERFHYNTQGLLVRASK----RGRFDVRYYY 2467
Cdd:NF041261 929 lhpdstLTAWPDNRIAEDAHYVYRYDEYGRLTEktdripegvirtdDERTHHYHYDSQHRLVFYTRiqhgEPLVESRYLY 1008
|
730
....*....|
gi 221329864 2468 DHLKRLTTRK 2477
Cdd:NF041261 1009 DPLGRRMAKR 1018
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
825-851 |
3.13e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.44 E-value: 3.13e-09
10 20
....*....|....*....|....*..
gi 221329864 825 NCKDNIDNDGDGMTDCSDSECCSHPAC 851
Cdd:NF033662 6 TCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2556-2632 |
3.16e-08 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 52.89 E-value: 3.16e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221329864 2556 SPFGHiVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVYDPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2632
Cdd:TIGR03696 2 DPYGE-VLSESGAAPNPLRFTGQYYDAETGLYYNG-ARYYDPELGRFLSPD------PIGLGGGLNLYAYVGNNPVN 70
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
660-683 |
2.79e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 43.11 E-value: 2.79e-05
10 20
....*....|....*....|....*.
gi 221329864 660 LCSGHGTCVA--GQCYCKAGWQGEDC 683
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1735-1865 |
2.82e-04 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 46.92 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1735 SSEIYVFNRYGQHVATKDLTSGKTRYSFlysknTSFGRLSTVTDASGnkIQFLRDYSN--VVSSIENTQDHKSEIQINGI 1812
Cdd:NF041261 535 STKQMTWSRYGQLLAFTDCSGYQTRYEY-----DRFGQMTAVHREEG--ISTYRRYDNrgQLTSVKDAQGRETRYEYNAA 607
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 221329864 1813 GIMTKLSEKGRQEIELDYDSnTGLLNSRSSGGETYIYQYDEFGRVTGMILPSG 1865
Cdd:NF041261 608 GDLTAVITPDGNRSETQYDA-WGKAVSTTQGGLTRSMEYDAAGRITTLTNENG 659
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1286-1387 |
3.98e-04 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 46.38 E-value: 3.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1286 ATQVSYQYYLAV-SPADGHLYISDPERHQIlrlvrleKVKDPSINS-DPVVGSGQRCIpgdegncgDGGPALLARLSHPK 1363
Cdd:PLN02919 798 GSEVLLQHPLGVlCAKDGQIYVADSYNHKI-------KKLDPATKRvTTLAGTGKAGF--------KDGKALKAQLSEPA 862
|
90 100
....*....|....*....|....*.
gi 221329864 1364 GLAIAADRTMYIADGTN--IRAVDPK 1387
Cdd:PLN02919 863 GLALGENGRLFVADTNNslIRYLDLN 888
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
661-772 |
5.73e-04 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 42.82 E-value: 5.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 661 CSGHGTCVAGQCYCKAGwqGEDCGtidqqvyqclpgcsehgtydletGQCVCERhwTGPD-CSQavCSLDCGRNGVCESG 739
Cdd:NF041328 49 CGAGQTCVAGACGCGPG--TVACG-----------------------GACVDTA--SDPAhCGA--CGAACAPGQVCEGG 99
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 221329864 740 KCR--CNSGWT--GNLC-----DQL---PCDSRCSEHGQCKNGTC 772
Cdd:NF041328 100 ACReaCSEGLTrcGGACvdlatDPLhcgACGVACDPGESCRGGAC 144
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
743-786 |
7.13e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 39.53 E-value: 7.13e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 221329864 743 CNSGWTGNLCDQLpCDSR--------CSEHGQCkngtcVCSQGWNGRHCTLP 786
Cdd:pfam01414 1 CDENYYGSTCSKF-CRPRddkfghytCDANGNK-----VCLPGWTGPYCDKP 46
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
563-586 |
8.63e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 8.63e-04
10 20
....*....|....*....|....*.
gi 221329864 563 DCSGRGSCYL--GKCDCIDGYQGVDC 586
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
629-651 |
1.87e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.87e-03
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1830-1866 |
1.89e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 37.96 E-value: 1.89e-03
10 20 30
....*....|....*....|....*....|....*..
gi 221329864 1830 YDSNTGLLNSRSSGGETYIYQYDEFGRVTGMILPSGE 1866
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
789-818 |
3.58e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.58e-03
10 20 30
....*....|....*....|....*....|
gi 221329864 789 ENGCSRHGQCTLENGEYRCDCIEGWAGRDC 818
Cdd:cd00054 8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
757-784 |
7.87e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.46 E-value: 7.87e-03
10 20 30
....*....|....*....|....*....|....
gi 221329864 757 CDSR--CSEHGQCKNG----TCVCSQGWNGRHCT 784
Cdd:cd00054 5 CASGnpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2889-2966 |
1.60e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 139.28 E-value: 1.60e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221329864 2889 KEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVK 2966
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1239-1544 |
7.35e-35 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 137.66 E-value: 7.35e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1239 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQL----------SATQVSYQYYLAVSPAdGHLYI 1306
Cdd:cd14953 14 GGGGTAARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfadgggAAAQFNTPSGVAVDAA-GNLYV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1307 SDPERHqilrlvRLEKVkDPSINSDPVVGSGQRcipgdeGNCGDGGpALLARLSHPKGLAIAADRTMYIADGTN--IRAV 1384
Cdd:cd14953 93 ADTGNH------RIRKI-TPDGVVSTLAGTGTA------GFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNhrIRKI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1385 DPKGVIHTLIGhhghhnhwSPAPCS---GTlmANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTp 1458
Cdd:cd14953 159 TPDGVVTTVAG--------TGGAGYagdGP--ATAAQFNNPTGVAVDA-AGNL-YVADRGnhrIRKITPDGVVTTVAGT- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1459 lhcsnGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTgsqtcdcaigGGS 1538
Cdd:cd14953 226 -----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR---IRKITPAGVVTTVAGGGAGF----------SGD 287
|
....*.
gi 221329864 1539 NGSATN 1544
Cdd:cd14953 288 GGPATS 293
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1983-2632 |
6.63e-30 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 130.65 E-value: 6.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1983 YSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFN 2062
Cdd:COG3209 375 GGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGG 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2063 RVEGWAWGPAELKYSYDRHGLLSEITSQQDGIVSFVYNDWNLVSEIGLASQRkfvlqYDDAGGLRHVVLPSGTRHSFSMQ 2142
Cdd:COG3209 455 AGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL-----GGTTTTTAGARGLVVTTGTTLTL 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2143 TSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTER 2222
Cdd:COG3209 530 GTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTT 609
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2223 ELEY-RWDFEYAAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQ 2301
Cdd:COG3209 610 TSGYtRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGT 689
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2302 PAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLV 2381
Cdd:COG3209 690 TSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLT 769
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2382 GVEAQEP-------WGFRYDDNGNLLSLTY-RGNTIPMEYNAQDRIVK-----------FGEGQYKYDARGLVAQ----- 2437
Cdd:COG3209 770 SETTPGGvtqgtytTRYTYDALGRLTSVTYpDGETVTYTYDALGRLTSvitvgsgggtdLQDRTYTYDAAGNITSitdal 849
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2438 --NAREERFHYNTQGLLVRASKRGRfDVRYYYDHLKRLTTRKDnfGNVTQFFYTNQQRPYEVSQiyspRDGKLMSLTYDD 2515
Cdd:COG3209 850 raGTLTQTYTYDALGRLTSATDPGT-TESYTYDANGNLTSRTD--GGTTTYTYDALGRLVSVTK----PDGTTTTYTYDA 922
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2516 VGHliyaqvyrhkyyvaTDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVY 2595
Cdd:COG3209 923 LGH--------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNG-ARYY 987
|
650 660 670
....*....|....*....|....*....|....*..
gi 221329864 2596 DPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2632
Cdd:COG3209 988 DPALGRFLSPD------PIGLAGGLNLYAYVGNNPVN 1018
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1237-1506 |
9.03e-27 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 113.78 E-value: 9.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1237 YCNGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTIL-----------QLSATQVSYQYYLAVSPAdGH 1303
Cdd:cd14953 66 FADGGGAAAQFNTPSGVAVDAAGNLYVADTgnHRIRKITPDGVVSTLAgtgtagfsddgGATAAQFNYPTGVAVDAA-GN 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1304 LYISDPERHQILRlvrlekvkdpsINSDPVV----GSGqrcipgdEGNCGDGGPALLARLSHPKGLAIAADRTMYIADGT 1379
Cdd:cd14953 145 LYVADTGNHRIRK-----------ITPDGVVttvaGTG-------GAGYAGDGPATAAQFNNPTGVAVDAAGNLYVADRG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1380 N--IRAVDPKGVIHTLIGHHGhhnhwspAPCSGTLMANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVV 1454
Cdd:cd14953 207 NhrIRKITPDGVVTTVAGTGT-------AGFSGDGGATAAQLNNPTGVAVDA-AGNL-YVADSGnhrIRKITPAGVVTTV 277
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 221329864 1455 AGTPlhCSNGGQDGRVNKTGADNVLGtvlaMAFSPFGNLYIADSDSRRVNSI 1506
Cdd:cd14953 278 AGGG--AGFSGDGGPATSAQFNNPTG----VAVDAAGNLYVADTGNNRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1244-1503 |
4.64e-19 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 89.69 E-value: 4.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1244 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSATQVSYQYY---LAVSPaDGHLYISDPERHQILRLv 1318
Cdd:cd05819 51 DGQFNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLASFGGSGDGDGEFNGprgIAVDS-SGNIYVADTGNHRIQKF- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1319 rlekvkDPSinsdpvvGSGQRCIPGDEGNCGDggpallarLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTLIGH 1396
Cdd:cd05819 129 ------DPD-------GEFLTTFGSGGSGPGQ--------FNGPTGVAVDSDGNIYVADTGNhrIQVFDPDGNFLTTFGS 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1397 HGHHNhwspapcsgtlmanqAQLQWPTGLALSPlDGSLHFID--DRLVLRLTSDMKIRVVAGTPLhcsnggqdgrvnktG 1474
Cdd:cd05819 188 TGTGP---------------GQFNYPTGIAVDS-DGNIYVADsgNNRVQVFDPDGAGFGGNGNFL--------------G 237
|
250 260
....*....|....*....|....*....
gi 221329864 1475 ADNVLGTVLAMAFSPFGNLYIADSDSRRV 1503
Cdd:cd05819 238 SDGQFNRPSGLAVDSDGNLYVADTGNNRI 266
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1349-1544 |
1.67e-18 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 89.51 E-value: 1.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1349 GDGGPALLARLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTLI--GHHGHHNHWSPApcsgtlmanqAQLQWPTG 1424
Cdd:cd14953 12 FSGGGGTAARFNSPSGVAVDAAGNLYVADRGNhrIRKITPDGVVTTVAgtGTAGFADGGGAA----------AQFNTPSG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1425 LALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTplhCSNGGQDGrvnkTGADN-VLGTVLAMAFSPFGNLYIADsds 1500
Cdd:cd14953 82 VAVDA-AGNL-YVADTGnhrIRKITPDGVVSTLAGT---GTAGFSDD----GGATAaQFNYPTGVAVDAAGNLYVAD--- 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 221329864 1501 RRVNSIRVVDTAGNMRYFAgkqeGTGSQtcdcaiGGGSNGSATN 1544
Cdd:cd14953 150 TGNHRIRKITPDGVVTTVA----GTGGA------GYAGDGPATA 183
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1243-1528 |
2.54e-16 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 81.60 E-value: 2.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1243 KDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSAT---QVSYQYYLAVSPaDGHLYISDPERHQILRL 1317
Cdd:cd05819 3 GPGELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSgdgQFNEPAGVAVDS-DGNLYVADTGNHRIQKF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1318 vrlekvkdpSINSDPVVGSGqrcIPGDegncGDGGpallarLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTLIG 1395
Cdd:cd05819 82 ---------DPDGNFLASFG---GSGD----GDGE------FNGPRGIAVDSSGNIYVADTGNhrIQKFDPDGEFLTTFG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1396 HHGhhnhwspapcsgtlmANQAQLQWPTGLALSPlDGSLhFIDDRLVLRltsdmkIRVVAgtplhcSNGGQDGRVNKTGA 1475
Cdd:cd05819 140 SGG---------------SGPGQFNGPTGVAVDS-DGNI-YVADTGNHR------IQVFD------PDGNFLTTFGSTGT 190
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 221329864 1476 -DNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTGSQ 1528
Cdd:cd05819 191 gPGQFNYPTGIAVDSDGNIYVADSGNNR---VQVFDPDGAGFGGNGNFLGSDGQ 241
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2067-2519 |
2.33e-14 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 80.05 E-value: 2.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2067 WAWGPA-ELKYSYDRHGllseitSQqdgIVSFVYNDWNLVSEIG--LASQRKFVLQYDDAGGLRHVVLPSGTRHSFSMQT 2143
Cdd:NF041261 322 YTYTEAgELLAVYDRSN------TQ---VRAFTYDAQHPGRMVAhrYAGRPEMCYRYDDTGRVTEQLNPAGLSYRYQYEQ 392
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2144 SigfiRCTYTPPGSTRAYLqhYSHAGALLQTILP---GDGARIVYRYNAAGQLTEVVHGDGR-SEFQYNEATGMPSTVSH 2219
Cdd:NF041261 393 D----RITITDSLNRREVL--HTEGEGGLKRVVKkehADGSVTRSGYDAAGRLTAQTDAAGRrTEYSLNVVSGDITDITT 466
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2220 TE-RELEYRWDfeyaagllaeERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGgqslPTQAFAYD-PRTGRPSLIG-- 2295
Cdd:NF041261 467 PDgRETKFYYN----------DGNQLTSVTSPDGLESRREYDEPGRLVSETSRSG----ETTRYRYDdPHSELPATTTda 532
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2296 -----QFRFSQPAQnQTQLHDGTASFTRTVDGRFQTQrmaLAIHRLEVFRMEFSYGVHGRISQTRtytrnmavNSYTNVK 2370
Cdd:NF041261 533 tgstkQMTWSRYGQ-LLAFTDCSGYQTRYEYDRFGQM---TAVHREEGISTYRRYDNRGQLTSVK--------DAQGRET 600
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2371 NYTWDCDGQLVGVEAqePWGFR----YDDNGNLLSLTYRGNTIPMEYNAQDRIVKF-----GEGQYKYDARGLVAQ---- 2437
Cdd:NF041261 601 RYEYNAAGDLTAVIT--PDGNRsetqYDAWGKAVSTTQGGLTRSMEYDAAGRITTLtnengSHSTFLYDALDRLVQqrgf 678
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2438 NAREERFHYNTQGLLVRASKRGrFDVRYYYDHLKRLTTRKDNFGNVTQFFYTNQQRPYEVSQIyspRDGKLMSL--TYDD 2515
Cdd:NF041261 679 DGRTQRYHYDLTGKLTQSEDEG-LVTLWHYDESDRITHRTVNGEPAEQWQYDEHGWLTDISHL---SEGHRVAVhyGYDD 754
|
....
gi 221329864 2516 VGHL 2519
Cdd:NF041261 755 KGRL 758
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1243-1434 |
8.40e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 71.20 E-value: 8.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1243 KDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTIL---QLSATQVSYQYYLAVSPaDGHLYISDPERHQILRL 1317
Cdd:cd05819 97 GDGEFNGPRGIAVDSSGNIYVADTgnHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDS-DGNIYVADTGNHRIQVF 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1318 vrlekvkDPSINSDPVVGSGqrcipgdegncGDGGpallARLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTlig 1395
Cdd:cd05819 176 -------DPDGNFLTTFGST-----------GTGP----GQFNYPTGIAVDSDGNIYVADSGNnrVQVFDPDGAGFG--- 230
|
170 180 190
....*....|....*....|....*....|....*....
gi 221329864 1396 hhghhnhwspapCSGTLMANQAQLQWPTGLALSPlDGSL 1434
Cdd:cd05819 231 ------------GNGNFLGSDGQFNRPSGLAVDS-DGNL 256
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1244-1519 |
1.02e-11 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 68.12 E-value: 1.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1244 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSATQvSYQYYLAVSPaDGHLYISDPERHQILRLvrle 1321
Cdd:COG4257 55 LGGGSGPHGIAVDPDGNLWFTDNgnNRIGRIDPKTGEITTFALPGGG-SNPHGIAFDP-DGNLWFTDQGGNRIGRL---- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1322 kvkdpsinsDPVVGSgqrcIPGDEGNCGDGGPAllarlshpkGLAIAADRTMYIAD-GTN-IRAVDPK-GVIHTLighhg 1398
Cdd:COG4257 129 ---------DPATGE----VTEFPLPTGGAGPY---------GIAVDPDGNLWVTDfGANaIGRIDPDtGTLTEY----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1399 hhnhwspapcsgtlmANQAQLQWPTGLALSPlDGSLHFIDdrlvlrltsdmkirvvagtplhcSNGGQDGRVN-KTGADN 1477
Cdd:COG4257 182 ---------------ALPTPGAGPRGLAVDP-DGNLWVAD-----------------------TGSGRIGRFDpKTGTVT 222
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 221329864 1478 VLGTVL------AMAFSPFGNLYIADSDSrrvNSIRVVDTAGNMRYFA 1519
Cdd:COG4257 223 EYPLPGggarpyGVAVDGDGRVWFAESGA---NRIVRFDPDTELTEYV 267
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1840-2477 |
1.20e-11 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 71.19 E-value: 1.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1840 RSSGGETYIYQYDEFGRVTGMILPSGeiVRITSQLADSQgLTVyvhasVESLFSRERIAGEANellvlGGVRSTFLKRgq 1919
Cdd:NF041261 358 RYAGRPEMCYRYDDTGRVTEQLNPAG--LSYRYQYEQDR-ITI-----TDSLNRREVLHTEGE-----GGLKRVVKKE-- 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1920 aHADAELKANntlvihgdngvvvEASAVARhplLEAalpveaemlamwshQSVTMGEGLTNSMYSVYSLVGDVRNPQQTL 1999
Cdd:NF041261 423 -HADGSVTRS-------------GYDAAGR---LTA--------------QTDAAGRRTEYSLNVVSGDITDITTPDGRE 471
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2000 NREIWVNQSRVIGV----------EFDQfTNRETFYDARRTPILIVAYD--QSGLPKSYYPTNGYPVNITYDRFNRVEGW 2067
Cdd:NF041261 472 TKFYYNDGNQLTSVtspdglesrrEYDE-PGRLVSETSRSGETTRYRYDdpHSELPATTTDATGSTKQMTWSRYGQLLAF 550
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2068 A-WGPAELKYSYDRHGLLSEItSQQDGIVSF-VYNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVLPSGTRhSFSMQTSI 2145
Cdd:NF041261 551 TdCSGYQTRYEYDRFGQMTAV-HREEGISTYrRYDNRGQLTSVKDAQGRETRYEYNAAGDLTAVITPDGNR-SETQYDAW 628
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2146 GFIRCTyTPPGSTRAylQHYSHAGALLqTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGmpsTVSHTERE-L 2224
Cdd:NF041261 629 GKAVST-TQGGLTRS--MEYDAAGRIT-TLTNENGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTG---KLTQSEDEgL 701
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2225 EYRWDFEyaagllAEERIDYVAKTGLSNAKFSYE---------YDSQLRVVAL------QGRIGGQSLPTQafayDPRTG 2289
Cdd:NF041261 702 VTLWHYD------ESDRITHRTVNGEPAEQWQYDehgwltdisHLSEGHRVAVhygyddKGRLTGERQTVE----NPETG 771
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2290 RpsLIGQFR----FSQPAQNQTQLHDGTASFTRTVDGRFQTQRMALA-----------IHRlEVFRMEFSYGVHGRISQT 2354
Cdd:NF041261 772 E--LLWQHEtghaYNEQGLANRVTPDSLPPVEWLTYGSGYLAGMKLGgtplveytrdrLHR-ETVRSFGGAGSNAAYELT 848
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2355 RTYT-----RNMAVNSYTNVKNYTWDCDGQLVGVEA-QEPWGFRYDDNGNLLS-------LTYR--------GNTIP--- 2410
Cdd:NF041261 849 TAYTpagqlQSQHLNSLVYDRDYTWNDNGDLVRISGpRQTREYGYSATGRLTGvhttaanLDIRipyatdpaGNRLPdpe 928
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 2411 ------MEYNAQDRIVKFGEGQYKYDARGLVAQ-------------NAREERFHYNTQGLLVRASK----RGRFDVRYYY 2467
Cdd:NF041261 929 lhpdstLTAWPDNRIAEDAHYVYRYDEYGRLTEktdripegvirtdDERTHHYHYDSQHRLVFYTRiqhgEPLVESRYLY 1008
|
730
....*....|
gi 221329864 2468 DHLKRLTTRK 2477
Cdd:NF041261 1009 DPLGRRMAKR 1018
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
825-851 |
3.13e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.44 E-value: 3.13e-09
10 20
....*....|....*....|....*..
gi 221329864 825 NCKDNIDNDGDGMTDCSDSECCSHPAC 851
Cdd:NF033662 6 TCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2556-2632 |
3.16e-08 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 52.89 E-value: 3.16e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221329864 2556 SPFGHiVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVYDPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2632
Cdd:TIGR03696 2 DPYGE-VLSESGAAPNPLRFTGQYYDAETGLYYNG-ARYYDPELGRFLSPD------PIGLGGGLNLYAYVGNNPVN 70
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1240-1398 |
6.13e-08 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 56.83 E-value: 6.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1240 GVAKDAKLLTPIALATGPDGSLYVGDFNL--VRRITPDGK-VYTI----LQLSATQVsyqyylAVSPADGHLYISDPERH 1312
Cdd:cd14962 49 GNAGPNRFVSPIGVAIDANGNLYVSDAELgkVFVFDRDGKfLRAIgagaLFKRPTGI------AVDPAGKRLYVVDTLAH 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1313 QIlrlvrleKVKDPSinsdpvvGSGQRCIpgdeGNCGDGGpallARLSHPKGLAIAADRTMYIADGTNIR--AVDPKGVI 1390
Cdd:cd14962 123 KV-------KVFDLD-------GRLLFDI----GKRGSGP----GEFNLPTDLAVDRDGNLYVTDTMNFRvqIFDADGKF 180
|
....*...
gi 221329864 1391 HTLIGHHG 1398
Cdd:cd14962 181 LRSFGERG 188
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1244-1503 |
8.07e-08 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 56.52 E-value: 8.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1244 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSAT---QVSYQYYLAVSPaDGHLYISDPERHQILRLv 1318
Cdd:cd14956 56 PGQFGRPRGLAVDKDGWLYVADYwgDRIQVFTLTGELQTIGGSSGSgpgQFNAPRGVAVDA-DGNLYVADFGNQRIQKF- 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1319 rlekvkdpsinsDP---VVGS-GQRCIPGDEGNcgdggpallarlsHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHT 1392
Cdd:cd14956 134 ------------DPdgsFLRQwGGTGIEPGSFN-------------YPRGVAVDPDGTLYVADTYNdrIQVFDNDGAFLR 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1393 LIGHHGHHNHWspapcsgtlmanqaqLQWPTGLALSPlDGSLHFID---DRlVLRLTSDMKIRVVAGTPlhcsnGGQDGR 1469
Cdd:cd14956 189 KWGGRGTGPGQ---------------FNYPYGIAIDP-DGNVFVADfgnNR-IQKFTADGTFLTSWGSP-----GTGPGQ 246
|
250 260 270
....*....|....*....|....*....|....
gi 221329864 1470 vnktgadnvLGTVLAMAFSPFGNLYIADSDSRRV 1503
Cdd:cd14956 247 ---------FKNPWGVVVDADGTVYVADSNNNRV 271
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1346-1514 |
2.01e-07 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 55.66 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1346 GNCG--DGGPALlARLSHPKGLAIAADRTMYIADGTN--IRAVDP-KGVIHTL--IGHHGHHNhwspapcSGTLMANQAQ 1418
Cdd:cd14951 4 GERGlkDGSFAE-ASFNEPQGLALLPGNILYVADTENhaLRKIDLeTGTVTTLagTGEQGRDG-------EGGGPGREQP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1419 LQwptglalSPLDGSLHFIDDRLVLR----------LTSDMKIRVVAGTplhcsngGQDGRVNKTGADNvlgTVLA---- 1484
Cdd:cd14951 76 LS-------SPWDVAWGPEDDILYIAmagthqiwayDLDTGTCRVFAGS-------GNEGNRNGPYPHE---AWFAqpsg 138
|
170 180 190
....*....|....*....|....*....|
gi 221329864 1485 MAFSPFGNLYIADSDSrrvNSIRVVDTAGN 1514
Cdd:cd14951 139 LSLAGWGELFVADSES---SAIRAVSLKDG 165
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
660-683 |
2.79e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 43.11 E-value: 2.79e-05
10 20
....*....|....*....|....*.
gi 221329864 660 LCSGHGTCVA--GQCYCKAGWQGEDC 683
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1293-1526 |
5.40e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 47.71 E-value: 5.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1293 YYLAVSPaDGHLYISDPERHQILRLvrlekvkdpsinsDPVVGSGQRcipgdegncgdggpALLARLSHPKGLAIAADRT 1372
Cdd:COG4257 20 RDVAVDP-DGAVWFTDQGGGRIGRL-------------DPATGEFTE--------------YPLGGGSGPHGIAVDPDGN 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1373 MYIADGTN--IRAVDPK-GVIHTLIGhhghhnhwsPAPCSGtlmanqaqlqwPTGLALSPlDGSLHFIDDR--LVLRLT- 1446
Cdd:COG4257 72 LWFTDNGNnrIGRIDPKtGEITTFAL---------PGGGSN-----------PHGIAFDP-DGNLWFTDQGgnRIGRLDp 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1447 SDMKIRVVAGTplhcSNGGQDGrvnktgadnvlgtvlAMAFSPFGNLYIADsdsRRVNSIRVVDTA-GNMRYFAGKQEGT 1525
Cdd:COG4257 131 ATGEVTEFPLP----TGGAGPY---------------GIAVDPDGNLWVTD---FGANAIGRIDPDtGTLTEYALPTPGA 188
|
.
gi 221329864 1526 G 1526
Cdd:COG4257 189 G 189
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1240-1322 |
6.53e-05 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 47.96 E-value: 6.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1240 GVAKDAKLLTPIALATGPDGSLYVGD-FN-LVRRITPD-GKVYTI---LQLSATQVSYQYY----LAVSPaDGHLYISDP 1309
Cdd:cd14951 188 GPGAEALLQHPLGVAALPDGSVYVADtYNhKIKRVDPAtGEVSTLagtGKAGYKDLEAQFSepsgLVVDG-DGRLYVADT 266
|
90
....*....|...
gi 221329864 1310 ERHQIlRLVRLEK 1322
Cdd:cd14951 267 NNHRI-RRLDLPT 278
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1295-1434 |
6.59e-05 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 47.96 E-value: 6.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1295 LAVSPaDGHLYISDPERhQILRLVRLEKVKDPSINSDPVVGSGQrcipgdeGNCGD-GGPALLARLSHPKGLAIAADRTM 1373
Cdd:cd14951 139 LSLAG-WGELFVADSES-SAIRAVSLKDGGVKTLVGGTRVGTGL-------FDFGDrDGPGAEALLQHPLGVAALPDGSV 209
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221329864 1374 YIADGTN--IRAVDPK-GVIHTLIghhghhnhwspapcsGTLMAN----QAQLQWPTGLALSPlDGSL 1434
Cdd:cd14951 210 YVADTYNhkIKRVDPAtGEVSTLA---------------GTGKAGykdlEAQFSEPSGLVVDG-DGRL 261
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1735-1865 |
2.82e-04 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 46.92 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1735 SSEIYVFNRYGQHVATKDLTSGKTRYSFlysknTSFGRLSTVTDASGnkIQFLRDYSN--VVSSIENTQDHKSEIQINGI 1812
Cdd:NF041261 535 STKQMTWSRYGQLLAFTDCSGYQTRYEY-----DRFGQMTAVHREEG--ISTYRRYDNrgQLTSVKDAQGRETRYEYNAA 607
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 221329864 1813 GIMTKLSEKGRQEIELDYDSnTGLLNSRSSGGETYIYQYDEFGRVTGMILPSG 1865
Cdd:NF041261 608 GDLTAVITPDGNRSETQYDA-WGKAVSTTQGGLTRSMEYDAAGRITTLTNENG 659
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1300-1526 |
3.48e-04 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 45.27 E-value: 3.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1300 ADGHLYISDPERHQILRLvrlekvkDPSinsdpvvGSGQRCIPGDEGncgdggpallarlsHPKGLAIAADRTMYIAD-G 1378
Cdd:COG3386 17 PDGRLYWVDIPGGRIHRY-------DPD-------GGAVEVFAEPSG--------------RPNGLAFDPDGRLLVADhG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1379 TNIRAVDPK-GVIHTLIGHHGHhnhwspapcsgtlmanqaQLQWPTGLALSPlDGSL------HFIDDRLVLRLTSDMKI 1451
Cdd:COG3386 69 RGLVRFDPAdGEVTVLADEYGK------------------PLNRPNDGVVDP-DGRLyftdmgEYLPTGALYRVDPDGSL 129
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221329864 1452 RVVAgTPLHCSNGgqdgrvnktgadnvlgtvlaMAFSPFGN-LYIADSDSRRVNSIRVVD--TAGNMRYFAGKQEGTG 1526
Cdd:COG3386 130 RVLA-DGLTFPNG--------------------IAFSPDGRtLYVADTGAGRIYRFDLDAdgTLGNRRVFADLPDGPG 186
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1286-1387 |
3.98e-04 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 46.38 E-value: 3.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1286 ATQVSYQYYLAV-SPADGHLYISDPERHQIlrlvrleKVKDPSINS-DPVVGSGQRCIpgdegncgDGGPALLARLSHPK 1363
Cdd:PLN02919 798 GSEVLLQHPLGVlCAKDGQIYVADSYNHKI-------KKLDPATKRvTTLAGTGKAGF--------KDGKALKAQLSEPA 862
|
90 100
....*....|....*....|....*.
gi 221329864 1364 GLAIAADRTMYIADGTN--IRAVDPK 1387
Cdd:PLN02919 863 GLALGENGRLFVADTNNslIRYLDLN 888
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1253-1394 |
4.63e-04 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.88 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1253 LATGPDGSLYVGDFNLVR------RITPDGKVYTIlqlsATQVSYQYYLAVSPADGHLYISDPERHQILRLvrlekvkdp 1326
Cdd:COG3386 98 GVVDPDGRLYFTDMGEYLptgalyRVDPDGSLRVL----ADGLTFPNGIAFSPDGRTLYVADTGAGRIYRF--------- 164
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1327 SINSDPVVGSGQRCIPGDEgncGDGGPAllarlshpkGLAIAADRTMYIA--DGTNIRAVDPKGVIHTLI 1394
Cdd:COG3386 165 DLDADGTLGNRRVFADLPD---GPGGPD---------GLAVDADGNLWVAlwGGGGVVRFDPDGELLGRI 222
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1239-1317 |
5.10e-04 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 44.62 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1239 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTIL---QLSATQVSYQYYLAVSPaDGHLYISDPERHQ 1313
Cdd:cd05819 187 STGTGPGQFNYPTGIAVDSDGNIYVADSgnNRVQVFDPDGAGFGGNgnfLGSDGQFNRPSGLAVDS-DGNLYVADTGNNR 265
|
....
gi 221329864 1314 ILRL 1317
Cdd:cd05819 266 IQVF 269
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
661-772 |
5.73e-04 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 42.82 E-value: 5.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 661 CSGHGTCVAGQCYCKAGwqGEDCGtidqqvyqclpgcsehgtydletGQCVCERhwTGPD-CSQavCSLDCGRNGVCESG 739
Cdd:NF041328 49 CGAGQTCVAGACGCGPG--TVACG-----------------------GACVDTA--SDPAhCGA--CGAACAPGQVCEGG 99
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 221329864 740 KCR--CNSGWT--GNLC-----DQL---PCDSRCSEHGQCKNGTC 772
Cdd:NF041328 100 ACReaCSEGLTrcGGACvdlatDPLhcgACGVACDPGESCRGGAC 144
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
743-786 |
7.13e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 39.53 E-value: 7.13e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 221329864 743 CNSGWTGNLCDQLpCDSR--------CSEHGQCkngtcVCSQGWNGRHCTLP 786
Cdd:pfam01414 1 CDENYYGSTCSKF-CRPRddkfghytCDANGNK-----VCLPGWTGPYCDKP 46
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
563-586 |
8.63e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 8.63e-04
10 20
....*....|....*....|....*.
gi 221329864 563 DCSGRGSCYL--GKCDCIDGYQGVDC 586
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
697-721 |
1.11e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.11e-03
|
| YliI |
COG2133 |
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism]; |
1250-1381 |
1.14e-03 |
|
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];
Pssm-ID: 441736 [Multi-domain] Cd Length: 365 Bit Score: 44.15 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1250 PIALATGPDGSLYVGD-FNLVRRITPDGKVYTILQLSATQVSYQY---YLAVSP---ADGHLYI--SDPERHQiLRLVRL 1320
Cdd:COG2133 39 PWGLAFLPDGRLLVTErAGRIRLLDDDGKLSTPVADLPVFAGGEGgllGVALDPdfaTNGYLYVayTDPGGAG-TRVARF 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221329864 1321 EKVKDPSINSDPVVGSGqrcIPGDEGNcgdggpallarlsHP-KGLAIAADRTMYIA--DGTNI 1381
Cdd:COG2133 118 TLSDGDTLTSEEVILDG---LPAGGGN-------------HNgGRLAFGPDGKLYVSvgDRGNA 165
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
629-651 |
1.87e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.87e-03
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1830-1866 |
1.89e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 37.96 E-value: 1.89e-03
10 20 30
....*....|....*....|....*....|....*..
gi 221329864 1830 YDSNTGLLNSRSSGGETYIYQYDEFGRVTGMILPSGE 1866
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
729-752 |
2.69e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.33 E-value: 2.69e-03
10 20
....*....|....*....|....*.
gi 221329864 729 DCGRNGVCES--GKCRCNSGWTGNLC 752
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
761-783 |
2.72e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.33 E-value: 2.72e-03
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
789-818 |
3.58e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.58e-03
10 20 30
....*....|....*....|....*....|
gi 221329864 789 ENGCSRHGQCTLENGEYRCDCIEGWAGRDC 818
Cdd:cd00054 8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
560-587 |
4.72e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 36.89 E-value: 4.72e-03
10 20
....*....|....*....|....*...
gi 221329864 560 CPNDCSGRGSCYLGKCDCIDGYQGVDCS 587
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
608-653 |
5.75e-03 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 37.22 E-value: 5.75e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 221329864 608 CEEGWKGAECDIpvgECEVPN-------CSSHGRCIegechCERGWKGPYCDQ 653
Cdd:pfam01414 1 CDENYYGSTCSK---FCRPRDdkfghytCDANGNKV-----CLPGWTGPYCDK 45
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1253-1387 |
6.56e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 41.41 E-value: 6.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1253 LATGPDGSLYVGD--FNLVRRITP-DGKVYTILQLS---------------ATQVSYQYYLAVSPA-DGHLYISDPERHQ 1313
Cdd:cd14951 139 LSLAGWGELFVADseSSAIRAVSLkDGGVKTLVGGTrvgtglfdfgdrdgpGAEALLQHPLGVAALpDGSVYVADTYNHK 218
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221329864 1314 ILRLvrlekvkdpsinsDPVVGSGQRCIPGDEGNCGDggpaLLARLSHPKGLAIAADRTMYIADgTN---IRAVDPK 1387
Cdd:cd14951 219 IKRV-------------DPATGEVSTLAGTGKAGYKD----LEAQFSEPSGLVVDGDGRLYVAD-TNnhrIRRLDLP 277
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1257-1536 |
7.26e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 41.03 E-value: 7.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1257 PDGSLYVGDF--NLVRRITPDGKVYTILQLSATQVSYqyyLAVSPaDGHLYISDPERhqilRLVRLEKvkdpsinsdpvv 1334
Cdd:COG3386 17 PDGRLYWVDIpgGRIHRYDPDGGAVEVFAEPSGRPNG---LAFDP-DGRLLVADHGR----GLVRFDP------------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1335 gsgqrcipgdegncGDGGPALLA-----RLSHPKGLAIAADRTMYIAD------GTNIRAVDPKGVIHTLIGHhghhnhw 1403
Cdd:COG3386 77 --------------ADGEVTVLAdeygkPLNRPNDGVVDPDGRLYFTDmgeylpTGALYRVDPDGSLRVLADG------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329864 1404 spapcsgtlmanqaqLQWPTGLALSPlDGS-LHFID--DRLVLRLTSDMKIRVVAGTPLHcsnggqDGRVNKTGADNvlg 1480
Cdd:COG3386 136 ---------------LTFPNGIAFSP-DGRtLYVADtgAGRIYRFDLDADGTLGNRRVFA------DLPDGPGGPDG--- 190
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 221329864 1481 tvlaMAFSPFGNLYIADSDSRRVnsiRVVDTAGNMRyfaGKQEGTGSQTCDCAIGG 1536
Cdd:COG3386 191 ----LAVDADGNLWVALWGGGGV---VRFDPDGELL---GRIELPERRPTNVAFGG 236
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
757-784 |
7.87e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.46 E-value: 7.87e-03
10 20 30
....*....|....*....|....*....|....
gi 221329864 757 CDSR--CSEHGQCKNG----TCVCSQGWNGRHCT 784
Cdd:cd00054 5 CASGnpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| EGF |
cd00053 |
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
790-818 |
8.00e-03 |
|
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.
Pssm-ID: 238010 Cd Length: 36 Bit Score: 36.30 E-value: 8.00e-03
10 20 30
....*....|....*....|....*....|
gi 221329864 790 NGCSRHGQCTLENGEYRCDCIEGWAG-RDC 818
Cdd:cd00053 6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSC 35
|
|
| |
