NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|221329977|ref|NP_001138205|]
View 

paralytic, isoform D [Drosophila melanogaster]

Protein Classification

sodium channel protein subunit alpha( domain architecture ID 11999295)

sodium channel protein subunit alpha is the ion conducting pore forming subunit of the channel that mediates the voltage-dependent sodium ion permeability of excitable membranes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1283-1554 2.32e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 227.92  E-value: 2.32e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1283 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVMLS 1361
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1362 LINLaaVWSGADDVPAFRSMRTLRALRPLRAVSRWEGMKVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1441
Cdd:pfam00520   80 LISL--VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1442 CEDMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYL 1521
Cdd:pfam00520  158 WENPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 221329977  1522 YFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1554
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1604-1854 2.80e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.87  E-value: 2.80e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1604 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1680
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1681 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1758
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1759 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1838
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 221329977  1839 IAVILENYSQATEDVQ 1854
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
798-1009 1.08e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 171.30  E-value: 1.08e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   798 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 873
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   874 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTVGALGNLTFVLCIIIFIFAVMGMQLFGKNYtdhkD 952
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----K 156
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 221329977   953 RFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 1009
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425 5.61e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 169.37  E-value: 5.61e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   141 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 212
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   213 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 288
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   289 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 368
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 221329977   369 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 425
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1544-1596 8.62e-29

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.96  E-value: 8.62e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 221329977 1544 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1596
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1035-1279 7.23e-27

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 109.73  E-value: 7.23e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1035 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPSEHGDNElelGHDEILAD 1096
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSLKKAPG---GKYELDED 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1097 glIKKGIKEqTQLEVAIgdgmeftihgdmknnkPkkskylnnatmignsINHQDNRLEHElnhrglslQDDDTASINSYG 1176
Cdd:pfam06512   78 --HMDFITN-PNLTVCV----------------P---------------IAEGESDLENE--------EDDDESSQSSDE 115
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1177 SHKNRPFKDESHKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCC 1247
Cdd:pfam06512  116 EKSKQQEQLEDDDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCF 163
                          250       260       270
                   ....*....|....*....|....*....|..
gi 221329977  1248 PDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQ 1279
Cdd:pfam06512  164 TEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
544-729 3.72e-25

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 463401  Cd Length: 163  Bit Score: 103.66  E-value: 3.72e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   544 TSLSLPGSPFNIRRGSRSShKYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyyg 622
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGS-IFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR--- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   623 NLGSRHSSYTSHQSRISyTSHG------------------DLLGG------------------MAVMGVSTmTKESKLRN 666
Cdd:pfam11933   59 RHLERRSSYQSQASRSS-RSHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRK 136
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221329977   667 RntRNQSvgatnggttcldtnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 729
Cdd:pfam11933  137 R--RLSS-----------------------------------YQLSMDYLEePFQRQRAVSAAS 163
GPHH super family cl25190
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1865-1912 4.36e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


The actual alignment was detected with superfamily member pfam16905:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 42.64  E-value: 4.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 221329977  1865 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1912
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1283-1554 2.32e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 227.92  E-value: 2.32e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1283 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVMLS 1361
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1362 LINLaaVWSGADDVPAFRSMRTLRALRPLRAVSRWEGMKVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1441
Cdd:pfam00520   80 LISL--VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1442 CEDMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYL 1521
Cdd:pfam00520  158 WENPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 221329977  1522 YFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1554
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1604-1854 2.80e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.87  E-value: 2.80e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1604 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1680
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1681 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1758
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1759 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1838
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 221329977  1839 IAVILENYSQATEDVQ 1854
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
798-1009 1.08e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 171.30  E-value: 1.08e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   798 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 873
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   874 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTVGALGNLTFVLCIIIFIFAVMGMQLFGKNYtdhkD 952
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----K 156
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 221329977   953 RFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 1009
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425 5.61e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 169.37  E-value: 5.61e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   141 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 212
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   213 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 288
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   289 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 368
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 221329977   369 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 425
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1544-1596 8.62e-29

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.96  E-value: 8.62e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 221329977 1544 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1596
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1035-1279 7.23e-27

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 109.73  E-value: 7.23e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1035 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPSEHGDNElelGHDEILAD 1096
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSLKKAPG---GKYELDED 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1097 glIKKGIKEqTQLEVAIgdgmeftihgdmknnkPkkskylnnatmignsINHQDNRLEHElnhrglslQDDDTASINSYG 1176
Cdd:pfam06512   78 --HMDFITN-PNLTVCV----------------P---------------IAEGESDLENE--------EDDDESSQSSDE 115
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1177 SHKNRPFKDESHKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCC 1247
Cdd:pfam06512  116 EKSKQQEQLEDDDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCF 163
                          250       260       270
                   ....*....|....*....|....*....|..
gi 221329977  1248 PDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQ 1279
Cdd:pfam06512  164 TEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
544-729 3.72e-25

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 103.66  E-value: 3.72e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   544 TSLSLPGSPFNIRRGSRSShKYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyyg 622
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGS-IFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR--- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   623 NLGSRHSSYTSHQSRISyTSHG------------------DLLGG------------------MAVMGVSTmTKESKLRN 666
Cdd:pfam11933   59 RHLERRSSYQSQASRSS-RSHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRK 136
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221329977   667 RntRNQSvgatnggttcldtnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 729
Cdd:pfam11933  137 R--RLSS-----------------------------------YQLSMDYLEePFQRQRAVSAAS 163
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1865-1912 4.36e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 42.64  E-value: 4.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 221329977  1865 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1912
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1283-1554 2.32e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 227.92  E-value: 2.32e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1283 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVMLS 1361
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1362 LINLaaVWSGADDVPAFRSMRTLRALRPLRAVSRWEGMKVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1441
Cdd:pfam00520   80 LISL--VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1442 CEDMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYL 1521
Cdd:pfam00520  158 WENPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 221329977  1522 YFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1554
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1604-1854 2.80e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.87  E-value: 2.80e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1604 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1680
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1681 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1758
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1759 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1838
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 221329977  1839 IAVILENYSQATEDVQ 1854
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
798-1009 1.08e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 171.30  E-value: 1.08e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   798 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 873
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   874 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTVGALGNLTFVLCIIIFIFAVMGMQLFGKNYtdhkD 952
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----K 156
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 221329977   953 RFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 1009
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425 5.61e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 169.37  E-value: 5.61e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   141 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 212
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   213 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 288
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   289 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 368
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 221329977   369 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 425
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1544-1596 8.62e-29

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.96  E-value: 8.62e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 221329977 1544 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1596
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1035-1279 7.23e-27

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 109.73  E-value: 7.23e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1035 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPSEHGDNElelGHDEILAD 1096
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSLKKAPG---GKYELDED 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1097 glIKKGIKEqTQLEVAIgdgmeftihgdmknnkPkkskylnnatmignsINHQDNRLEHElnhrglslQDDDTASINSYG 1176
Cdd:pfam06512   78 --HMDFITN-PNLTVCV----------------P---------------IAEGESDLENE--------EDDDESSQSSDE 115
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1177 SHKNRPFKDESHKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCC 1247
Cdd:pfam06512  116 EKSKQQEQLEDDDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCF 163
                          250       260       270
                   ....*....|....*....|....*....|..
gi 221329977  1248 PDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQ 1279
Cdd:pfam06512  164 TEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
544-729 3.72e-25

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 103.66  E-value: 3.72e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   544 TSLSLPGSPFNIRRGSRSShKYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyyg 622
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGS-IFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR--- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   623 NLGSRHSSYTSHQSRISyTSHG------------------DLLGG------------------MAVMGVSTmTKESKLRN 666
Cdd:pfam11933   59 RHLERRSSYQSQASRSS-RSHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRK 136
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221329977   667 RntRNQSvgatnggttcldtnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 729
Cdd:pfam11933  137 R--RLSS-----------------------------------YQLSMDYLEePFQRQRAVSAAS 163
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1640-1847 4.49e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 56.13  E-value: 4.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1640 IFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSdiIEKYFVSPTLLRVV-----------RVAKVGRVL 1708
Cdd:pfam08016   19 VFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLN--IYRDFLADRLIKSVeaspvtfidfdRVAQLDNLY 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977  1709 RLVKG----------------AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMhvkeksgiNDVYNFKTFG 1772
Cdd:pfam08016   97 RIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--------TQAPNFSNFV 168
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221329977  1773 QSMILLFQMstsagwdgVLDAIINEEACDppdndkgypgncGSATVGITFLLSYLVISFLIVINMYIAVILENYS 1847
Cdd:pfam08016  169 KSILTLFRT--------ILGDFGYNEIFS------------GNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 223
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1865-1912 4.36e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 42.64  E-value: 4.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 221329977  1865 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1912
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
886-980 1.84e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 41.88  E-value: 1.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329977   886 LSVLRSFRLLRVFKlakswpTLNLLISIMGRTVGALGNLTFVLCIIIFIFAVMGMQLFGKNYtdhkdrfpdgdlprWNFT 965
Cdd:pfam08016  106 LTWLKLFKVLRFNK------TMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQA--------------PNFS 165
                           90
                   ....*....|....*
gi 221329977   966 DFMHSFMIVFRVLCG 980
Cdd:pfam08016  166 NFVKSILTLFRTILG 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure