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Conserved domains on  [gi|221307471|ref|NP_001138284|]
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platelet glycoprotein Ib beta chain precursor [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 10635600)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-54 8.48e-07

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 8.48e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 221307471    21 CPHVCSCSAGVVDCSNRALTtaTLPSSFPASTTE 54
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLT--EVPLDLPPDTTL 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
84-129 7.82e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 7.82e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 221307471    84 NSWACDCAILYLRGWMLKRGSDPSMRNVSCSSPAHLRGRLIVYLPE 129
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHS 46
 
Name Accession Description Interval E-value
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-54 8.48e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 8.48e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 221307471    21 CPHVCSCSAGVVDCSNRALTtaTLPSSFPASTTE 54
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLT--EVPLDLPPDTTL 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
84-129 7.82e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 7.82e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 221307471    84 NSWACDCAILYLRGWMLKRGSDPSMRNVSCSSPAHLRGRLIVYLPE 129
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHS 46
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 21-49 1.73e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.61  E-value: 1.73e-04
                          10        20
                  ....*....|....*....|....*....
gi 221307471   21 CPHVCSCSAGVVDCSNRALTtaTLPSSFP 49
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLT--AVPRDLP 28
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 57-135 2.40e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 38.52  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307471    57 LNENHLTALPTGLLDALPALRRVALHGNSWACDCAILYLRGWMLKRGSDPSMRNVS-CSSPAHLRGRLIVYLPeqeLLDS 135
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGPGALAGQPLLGIP---LLDS 78
 
Name Accession Description Interval E-value
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-54 8.48e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 8.48e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 221307471    21 CPHVCSCSAGVVDCSNRALTtaTLPSSFPASTTE 54
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLT--EVPLDLPPDTTL 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
84-129 7.82e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 7.82e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 221307471    84 NSWACDCAILYLRGWMLKRGSDPSMRNVSCSSPAHLRGRLIVYLPE 129
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHS 46
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 21-49 1.73e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.61  E-value: 1.73e-04
                          10        20
                  ....*....|....*....|....*....
gi 221307471   21 CPHVCSCSAGVVDCSNRALTtaTLPSSFP 49
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLT--AVPRDLP 28
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 57-135 2.40e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 38.52  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307471    57 LNENHLTALPTGLLDALPALRRVALHGNSWACDCAILYLRGWMLKRGSDPSMRNVS-CSSPAHLRGRLIVYLPeqeLLDS 135
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGPGALAGQPLLGIP---LLDS 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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