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Conserved domains on  [gi|222144305|ref|NP_001138412|]
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vitelline membrane outer layer protein 1 homolog isoform 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VMO-I super family cl27236
Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in ...
 36-100 6.93e-28

Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the outer layer; VMO-I has three distinct internal repeats; all three repeats are used to define the domain here; VMO-I has recently been shown to synthesize N-acetylchito-oligosaccharides from N-acetylglucosamine; may be a carbohydrate-binding protein; member of the beta-prism-fold family


The actual alignment was detected with superfamily member pfam03762:

Pssm-ID: 452732  Cd Length: 166  Bit Score: 99.27  E-value: 6.93e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222144305   36 IEVTSGGPWGDWAWPEMCPDGFFASGFSLKVEPPQGIpGDDTALNGIRLHCARGNVLGNTHVLGR 100
Cdd:pfam03762   1 ITVPNGGNWGDWGPWEMCPDGSFAYGFSIKVEQPQGF-GDDTALNAIRLFCKPLDHDLNTNITSG 64
 
Name Accession Description Interval E-value
VOMI pfam03762
Vitelline membrane outer layer protein I (VOMI); VOMI binds tightly to ovomucin fibrils of the ...
 36-100 6.93e-28

Vitelline membrane outer layer protein I (VOMI); VOMI binds tightly to ovomucin fibrils of the egg yolk membrane. The structure that consists of three beta-sheets forming Greek key motifs, which are related by an internal pseudo three-fold symmetry. Furthermore, the structure of VOMI has strong similarity to the structure of the delta-endotoxin, as well as a carbohydrate-binding site in the top region of the common fold.


Pssm-ID: 427492  Cd Length: 166  Bit Score: 99.27  E-value: 6.93e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222144305   36 IEVTSGGPWGDWAWPEMCPDGFFASGFSLKVEPPQGIpGDDTALNGIRLHCARGNVLGNTHVLGR 100
Cdd:pfam03762   1 ITVPNGGNWGDWGPWEMCPDGSFAYGFSIKVEQPQGF-GDDTALNAIRLFCKPLDHDLNTNITSG 64
VMO-I cd00220
Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in ...
 35-91 3.10e-21

Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the outer layer; VMO-I has three distinct internal repeats; all three repeats are used to define the domain here; VMO-I has recently been shown to synthesize N-acetylchito-oligosaccharides from N-acetylglucosamine; may be a carbohydrate-binding protein; member of the beta-prism-fold family


Pssm-ID: 238135  Cd Length: 177  Bit Score: 82.44  E-value: 3.10e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 222144305  35 VIEVTSGGPWGDWAWPEMCPDGFFASGFSLKVEPPQGiPGDDTALNGIRLHCARGNV 91
Cdd:cd00220    2 VIESPNGGNWGTWGQWERCPSGSFANGFQLKYETPQG-FSDDTGLNAIALFCNPPDG 57
 
Name Accession Description Interval E-value
VOMI pfam03762
Vitelline membrane outer layer protein I (VOMI); VOMI binds tightly to ovomucin fibrils of the ...
 36-100 6.93e-28

Vitelline membrane outer layer protein I (VOMI); VOMI binds tightly to ovomucin fibrils of the egg yolk membrane. The structure that consists of three beta-sheets forming Greek key motifs, which are related by an internal pseudo three-fold symmetry. Furthermore, the structure of VOMI has strong similarity to the structure of the delta-endotoxin, as well as a carbohydrate-binding site in the top region of the common fold.


Pssm-ID: 427492  Cd Length: 166  Bit Score: 99.27  E-value: 6.93e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222144305   36 IEVTSGGPWGDWAWPEMCPDGFFASGFSLKVEPPQGIpGDDTALNGIRLHCARGNVLGNTHVLGR 100
Cdd:pfam03762   1 ITVPNGGNWGDWGPWEMCPDGSFAYGFSIKVEQPQGF-GDDTALNAIRLFCKPLDHDLNTNITSG 64
VMO-I cd00220
Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in ...
 35-91 3.10e-21

Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the outer layer; VMO-I has three distinct internal repeats; all three repeats are used to define the domain here; VMO-I has recently been shown to synthesize N-acetylchito-oligosaccharides from N-acetylglucosamine; may be a carbohydrate-binding protein; member of the beta-prism-fold family


Pssm-ID: 238135  Cd Length: 177  Bit Score: 82.44  E-value: 3.10e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 222144305  35 VIEVTSGGPWGDWAWPEMCPDGFFASGFSLKVEPPQGiPGDDTALNGIRLHCARGNV 91
Cdd:cd00220    2 VIESPNGGNWGTWGQWERCPSGSFANGFQLKYETPQG-FSDDTGLNAIALFCNPPDG 57
VOMI pfam03762
Vitelline membrane outer layer protein I (VOMI); VOMI binds tightly to ovomucin fibrils of the ...
 37-92 3.31e-15

Vitelline membrane outer layer protein I (VOMI); VOMI binds tightly to ovomucin fibrils of the egg yolk membrane. The structure that consists of three beta-sheets forming Greek key motifs, which are related by an internal pseudo three-fold symmetry. Furthermore, the structure of VOMI has strong similarity to the structure of the delta-endotoxin, as well as a carbohydrate-binding site in the top region of the common fold.


Pssm-ID: 427492  Cd Length: 166  Bit Score: 66.53  E-value: 3.31e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 222144305   37 EVTSG-GPWGDWAWPEMCPDGFFASGFSLKVEPPQGIpGDDTALNGIRLHCARGNVL 92
Cdd:pfam03762  60 NITSGeGFWGDWSGIQYCPAGGYLTGFQLRVEPPQGI-GDDTAANNIRFRCSNGEEL 115
VMO-I cd00220
Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in ...
 37-100 7.50e-12

Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the outer layer; VMO-I has three distinct internal repeats; all three repeats are used to define the domain here; VMO-I has recently been shown to synthesize N-acetylchito-oligosaccharides from N-acetylglucosamine; may be a carbohydrate-binding protein; member of the beta-prism-fold family


Pssm-ID: 238135  Cd Length: 177  Bit Score: 58.17  E-value: 7.50e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222144305  37 EVTSG-GPWGDWAWPEMCPDGFFASGFSLKVEPPQGIpGDDTALNGIRLHCARGNVLGNTHVLGR 100
Cdd:cd00220   65 EIISGeGPWGSWREIQWCPNGTVIVGFALRSEPEQGK-GDDTGANNFAAYCGRPEGRRKKTLSAE 128
VOMI pfam03762
Vitelline membrane outer layer protein I (VOMI); VOMI binds tightly to ovomucin fibrils of the ...
 21-86 1.66e-10

Vitelline membrane outer layer protein I (VOMI); VOMI binds tightly to ovomucin fibrils of the egg yolk membrane. The structure that consists of three beta-sheets forming Greek key motifs, which are related by an internal pseudo three-fold symmetry. Furthermore, the structure of VOMI has strong similarity to the structure of the delta-endotoxin, as well as a carbohydrate-binding site in the top region of the common fold.


Pssm-ID: 427492  Cd Length: 166  Bit Score: 54.21  E-value: 1.66e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222144305   21 FTCAQTDGRNGYTavievTSGGPWGDWAwPEMCPDGFFASGFSLKVEPPQGIpGDDTALNGIRLHC 86
Cdd:pfam03762 107 FRCSNGEELEGDG-----NTWGDWGEWS-TDQCPGGTAICGIQTRVEPYQGG-LDDTALNDVRFFC 165
VMO-I cd00220
Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in ...
 21-88 5.32e-09

Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the outer layer; VMO-I has three distinct internal repeats; all three repeats are used to define the domain here; VMO-I has recently been shown to synthesize N-acetylchito-oligosaccharides from N-acetylglucosamine; may be a carbohydrate-binding protein; member of the beta-prism-fold family


Pssm-ID: 238135  Cd Length: 177  Bit Score: 50.47  E-value: 5.32e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222144305  21 FTCAQTDGRNGYTAVIEvTSGGPWGDWAWPEMCPDGFFASGFSLKVEPPQGIpGDDTALNGIRLHCAR 88
Cdd:cd00220  112 AYCGRPEGRRKKTLSAE-GDTNEWGSWTKDQFCPAGQAVCGIQTRIEPPQGL-GDDTALNNVNLKCCR 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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