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Conserved domains on  [gi|223029476|ref|NP_001138582|]
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protein kinase C-binding protein NELL2 isoform d [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11259343)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 52-237 4.42e-55

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


:

Pssm-ID: 214560  Cd Length: 184  Bit Score: 187.95  E-value: 4.42e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476    52 QIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPrsikASTATAEQFFQKlRNKHEFTILVTLKQTHLNSGVILSIHH 131
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPGSPAYRLGDPA----LVPQPTRDLFPS-GLPEDFSLLTTFRQTPKSRGVLFAIYD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476   132 -LDHRYLELESSGHRNEVRLHYRSGSHRPHTEVFP-YILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS--TDLP 207
Cdd:smart00210  76 aQNVRQFGLEVDGRANTLLLRYQGVDGKQHTVSFRnLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGqpPIDT 155

                          170       180       190
                   ....*....|....*....|....*....|
gi 223029476   208 LGTTFWLGQRNNaHGYFKGIMQDVQLLVMP 237
Cdd:smart00210 156 DGIEVRGAQAAD-RKPFQGDLQQLKIVCDP 184
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 509-544 7.64e-10

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 54.53  E-value: 7.64e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 223029476  509 CITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTC 544
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
625-656 5.29e-09

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 52.24  E-value: 5.29e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 223029476  625 DIDECGTGRHSCANDTICFNLDGGYDCRCPHG 656
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 297-353 7.55e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 46.65  E-value: 7.55e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 223029476  297 CTMKGTTYREFESW-IDGCKNCTCLNGTIQCETLICPNPDCPLKSaLAYVDGKCCKEC 353
Cdd:pfam00093   1 CVQNGVVYENGETWkPDLCTICTCDDGKVLCDKIICPPLDCPNPR-LEIPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
463-494 1.22e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 1.22e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 223029476  463 DIDECAEGRHYCRENTMCVNTPGSFMCICKTG 494
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 728-778 3.42e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 45.11  E-value: 3.42e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 223029476  728 GETLYNSGDTWVQN-CQQCRCLQGEVDCWPLPCPDVECE--FSILPENECCPRC 778
Cdd:pfam00093   4 NGVVYENGETWKPDlCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
578-612 4.78e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 4.78e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 223029476   578 DIDECSDGFVqCDSRANCINLPGWYHCECRDGYHD 612
Cdd:smart00179   1 DIDECASGNP-CQNGGTCVNTVGSYRCECPPGYTD 34
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 663-715 1.98e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.02  E-value: 1.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 223029476  663 CIHDGKVKHNGQIWVLenDRCSVCSCQNGFVMCRRMVC---DCENPT---VDLFCCPEC 715
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICpplDCPNPRleiPPGECCPVC 57
 
Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 52-237 4.42e-55

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 187.95  E-value: 4.42e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476    52 QIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPrsikASTATAEQFFQKlRNKHEFTILVTLKQTHLNSGVILSIHH 131
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPGSPAYRLGDPA----LVPQPTRDLFPS-GLPEDFSLLTTFRQTPKSRGVLFAIYD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476   132 -LDHRYLELESSGHRNEVRLHYRSGSHRPHTEVFP-YILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS--TDLP 207
Cdd:smart00210  76 aQNVRQFGLEVDGRANTLLLRYQGVDGKQHTVSFRnLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGqpPIDT 155

                          170       180       190
                   ....*....|....*....|....*....|
gi 223029476   208 LGTTFWLGQRNNaHGYFKGIMQDVQLLVMP 237
Cdd:smart00210 156 DGIEVRGAQAAD-RKPFQGDLQQLKIVCDP 184
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 99-233 4.44e-12

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 64.75  E-value: 4.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476  99 QFFQKLRNKHEFTILVTLKqTHLNSGVILSIHHLD-HRYLELE-SSGHrneVRLHYRSGSHRPHTEVfPYILADDKWHKL 176
Cdd:cd00110   11 RLPTLPAPRTRLSISFSFR-TTSPNGLLLYAGSQNgGDFLALElEDGR---LVLRYDLGSGSLVLSS-KTPLNDGQWHSV 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223029476 177 SLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNAHG--------YFKGIMQDVQL 233
Cdd:cd00110   86 SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKspglpvspGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 123-233 1.37e-10

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 59.74  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476  123 SGVILSIHHLDHRYLELE-SSGHrneVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEK 201
Cdd:pfam02210   7 NGLLLYAGGGGSDFLALElVNGR---LVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPPG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 223029476  202 PSTDLPLGTTFWLG--------QRNNAHGYFKGIMQDVQL 233
Cdd:pfam02210  84 ESLLLNLNGPLYLGglppllllPALPVRAGFVGCIRDVRV 123
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 509-544 7.64e-10

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 54.53  E-value: 7.64e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 223029476  509 CITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTC 544
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
625-656 5.29e-09

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 52.24  E-value: 5.29e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 223029476  625 DIDECGTGRHSCANDTICFNLDGGYDCRCPHG 656
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 297-353 7.55e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 46.65  E-value: 7.55e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 223029476  297 CTMKGTTYREFESW-IDGCKNCTCLNGTIQCETLICPNPDCPLKSaLAYVDGKCCKEC 353
Cdd:pfam00093   1 CVQNGVVYENGETWkPDLCTICTCDDGKVLCDKIICPPLDCPNPR-LEIPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
463-494 1.22e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 1.22e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 223029476  463 DIDECAEGRHYCRENTMCVNTPGSFMCICKTG 494
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 728-778 3.42e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.11  E-value: 3.42e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 223029476  728 GETLYNSGDTWVQN-CQQCRCLQGEVDCWPLPCPDVECE--FSILPENECCPRC 778
Cdd:pfam00093   4 NGVVYENGETWKPDlCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
725-778 8.67e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.04  E-value: 8.67e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 223029476   725 HQNGEtLYNSGDTWVQN-CQQCRCLQGE-VDCWPLPCPDV-ECEFSIL--PENECCPRC 778
Cdd:smart00214   2 VHNGR-VYNDGETWKPDpCQICTCLDGTtVLCDPVECPPPpDCPNPERvkPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
463-495 1.20e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.20e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 223029476   463 DIDECAEGrHYCRENTMCVNTPGSFMCICKTGY 495
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
578-612 4.78e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 4.78e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 223029476   578 DIDECSDGFVqCDSRANCINLPGWYHCECRDGYHD 612
Cdd:smart00179   1 DIDECASGNP-CQNGGTCVNTVGSYRCECPPGYTD 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 458-500 4.81e-05

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 4.81e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 223029476 458 NAYCEDIDECAEGRHYCREntMCVNTPGSFMCICKTGYIRIDD 500
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQ--VCISTPGSYLCACTEGYALLED 221
EGF_CA smart00179
Calcium-binding EGF-like domain;
507-545 3.00e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 3.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 223029476   507 DECITNqHNCDENALCFNTVGGHNCVCKPGYTgNGTTCK 545
Cdd:smart00179   3 DECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 578-611 3.60e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 3.60e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 223029476 578 DIDECSDGFVqCDSRANCINLPGWYHCECRDGYH 611
Cdd:cd00054    1 DIDECASGNP-CQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 507-539 8.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 8.81e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 223029476 507 DECiTNQHNCDENALCFNTVGGHNCVCKPGYTG 539
Cdd:cd00054    3 DEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
VWC smart00214
von Willebrand factor (vWF) type C domain;
297-353 1.13e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.88  E-value: 1.13e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476   297 CTMKGTTYREFESWIDGCKN-CTCLNG-TIQCETLICP-NPDCPLKSaLAYVDGKCCKEC 353
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQiCTCLDGtTVLCDPVECPpPPDCPNPE-RVKPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
625-664 1.35e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 223029476   625 DIDECGTGrHSCANDTICFNLDGGYDCRCPHGKNCTGDCI 664
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 663-715 1.98e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 1.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 223029476  663 CIHDGKVKHNGQIWVLenDRCSVCSCQNGFVMCRRMVC---DCENPT---VDLFCCPEC 715
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICpplDCPNPRleiPPGECCPVC 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 625-656 4.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 4.79e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 223029476 625 DIDECGTGrHSCANDTICFNLDGGYDCRCPHG 656
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPG 31
 
Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 52-237 4.42e-55

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 187.95  E-value: 4.42e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476    52 QIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPrsikASTATAEQFFQKlRNKHEFTILVTLKQTHLNSGVILSIHH 131
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPGSPAYRLGDPA----LVPQPTRDLFPS-GLPEDFSLLTTFRQTPKSRGVLFAIYD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476   132 -LDHRYLELESSGHRNEVRLHYRSGSHRPHTEVFP-YILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS--TDLP 207
Cdd:smart00210  76 aQNVRQFGLEVDGRANTLLLRYQGVDGKQHTVSFRnLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGqpPIDT 155

                          170       180       190
                   ....*....|....*....|....*....|
gi 223029476   208 LGTTFWLGQRNNaHGYFKGIMQDVQLLVMP 237
Cdd:smart00210 156 DGIEVRGAQAAD-RKPFQGDLQQLKIVCDP 184
LamG smart00282
Laminin G domain;
123-233 3.20e-14

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.06  E-value: 3.20e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476   123 SGVILSIHHLD-HRYLELESS-GHrneVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVE 200
Cdd:smart00282  12 NGLLLYAGSKGgGDYLALELRdGR---LVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGGNRVSGESP 88

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 223029476   201 KPSTDLPLGTTFWLGQRNNAHG--------YFKGIMQDVQL 233
Cdd:smart00282  89 GGLTILNLDGPLYLGGLPEDLKlpplpvtpGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 99-233 4.44e-12

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 64.75  E-value: 4.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476  99 QFFQKLRNKHEFTILVTLKqTHLNSGVILSIHHLD-HRYLELE-SSGHrneVRLHYRSGSHRPHTEVfPYILADDKWHKL 176
Cdd:cd00110   11 RLPTLPAPRTRLSISFSFR-TTSPNGLLLYAGSQNgGDFLALElEDGR---LVLRYDLGSGSLVLSS-KTPLNDGQWHSV 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223029476 177 SLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNAHG--------YFKGIMQDVQL 233
Cdd:cd00110   86 SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKspglpvspGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 123-233 1.37e-10

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 59.74  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476  123 SGVILSIHHLDHRYLELE-SSGHrneVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEK 201
Cdd:pfam02210   7 NGLLLYAGGGGSDFLALElVNGR---LVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPPG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 223029476  202 PSTDLPLGTTFWLG--------QRNNAHGYFKGIMQDVQL 233
Cdd:pfam02210  84 ESLLLNLNGPLYLGglppllllPALPVRAGFVGCIRDVRV 123
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 509-544 7.64e-10

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 54.53  E-value: 7.64e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 223029476  509 CITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTC 544
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
625-656 5.29e-09

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 52.24  E-value: 5.29e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 223029476  625 DIDECGTGRHSCANDTICFNLDGGYDCRCPHG 656
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 297-353 7.55e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 46.65  E-value: 7.55e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 223029476  297 CTMKGTTYREFESW-IDGCKNCTCLNGTIQCETLICPNPDCPLKSaLAYVDGKCCKEC 353
Cdd:pfam00093   1 CVQNGVVYENGETWkPDLCTICTCDDGKVLCDKIICPPLDCPNPR-LEIPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
507-536 9.86e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.69  E-value: 9.86e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 223029476  507 DECITNQHNCDENALCFNTVGGHNCVCKPG 536
Cdd:pfam07645   3 DECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
463-494 1.22e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 1.22e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 223029476  463 DIDECAEGRHYCRENTMCVNTPGSFMCICKTG 494
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 728-778 3.42e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.11  E-value: 3.42e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 223029476  728 GETLYNSGDTWVQN-CQQCRCLQGEVDCWPLPCPDVECE--FSILPENECCPRC 778
Cdd:pfam00093   4 NGVVYENGETWKPDlCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
Laminin_G_1 pfam00054
Laminin G domain;
123-239 7.76e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 46.16  E-value: 7.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476  123 SGVILSIHHLDHR-YLELESsgHRNEVRLHYRSGSHRPHTeVFPYILADDKWHKLSLAISASHLILHIDcnKIYERVVEK 201
Cdd:pfam00054   7 SGLLLYNGTQTERdFLALEL--RDGRLEVSYDLGSGAAVV-RSGDKLNDGKWHSVELERNGRSGTLSVD--GEARPTGES 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 223029476  202 PS---TDLPLGTTFWLG--------QRNNAHG-YFKGIMQDVQLLVMPQG 239
Cdd:pfam00054  82 PLgatTDLDVDGPLYVGglpslgvkKRRLAISpSFDGCIRDVIVNGKPLD 131
VWC smart00214
von Willebrand factor (vWF) type C domain;
725-778 8.67e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.04  E-value: 8.67e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 223029476   725 HQNGEtLYNSGDTWVQN-CQQCRCLQGE-VDCWPLPCPDV-ECEFSIL--PENECCPRC 778
Cdd:smart00214   2 VHNGR-VYNDGETWKPDpCQICTCLDGTtVLCDPVECPPPpDCPNPERvkPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
463-495 1.20e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.20e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 223029476   463 DIDECAEGrHYCRENTMCVNTPGSFMCICKTGY 495
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
578-612 4.78e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 4.78e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 223029476   578 DIDECSDGFVqCDSRANCINLPGWYHCECRDGYHD 612
Cdd:smart00179   1 DIDECASGNP-CQNGGTCVNTVGSYRCECPPGYTD 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 458-500 4.81e-05

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 4.81e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 223029476 458 NAYCEDIDECAEGRHYCREntMCVNTPGSFMCICKTGYIRIDD 500
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQ--VCISTPGSYLCACTEGYALLED 221
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 463-496 1.24e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.24e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 223029476 463 DIDECAEGrHYCRENTMCVNTPGSFMCICKTGYI 496
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
507-545 3.00e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 3.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 223029476   507 DECITNqHNCDENALCFNTVGGHNCVCKPGYTgNGTTCK 545
Cdd:smart00179   3 DECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 578-611 3.60e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 3.60e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 223029476 578 DIDECSDGFVqCDSRANCINLPGWYHCECRDGYH 611
Cdd:cd00054    1 DIDECASGNP-CQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 507-539 8.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 8.81e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 223029476 507 DECiTNQHNCDENALCFNTVGGHNCVCKPGYTG 539
Cdd:cd00054    3 DEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
VWC smart00214
von Willebrand factor (vWF) type C domain;
297-353 1.13e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.88  E-value: 1.13e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476   297 CTMKGTTYREFESWIDGCKN-CTCLNG-TIQCETLICP-NPDCPLKSaLAYVDGKCCKEC 353
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQiCTCLDGtTVLCDPVECPpPPDCPNPE-RVKPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
625-664 1.35e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 223029476   625 DIDECGTGrHSCANDTICFNLDGGYDCRCPHGKNCTGDCI 664
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 663-715 1.98e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 1.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 223029476  663 CIHDGKVKHNGQIWVLenDRCSVCSCQNGFVMCRRMVC---DCENPT---VDLFCCPEC 715
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICpplDCPNPRleiPPGECCPVC 57
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 109-233 2.00e-03

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 39.67  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223029476  109 EFTILVTLKQTHLNSG--VILSIHHLDHRYLELESSGHrneVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLI 186
Cdd:pfam13385  18 DFTVSAWVKPDSLPGWarAIISSSGGGGYSLGLDGDGR---LRFAVNGGNGGWDTVTSGASVPLGQWTHVAVTYDGGTLR 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 223029476  187 LHIDCNKIYERVVeKPSTDLPLGTTFWLGQRNNAHGYFKGIMQDVQL 233
Cdd:pfam13385  95 LYVNGVLVGSSTL-TGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRI 140
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
297-338 3.14e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 36.77  E-value: 3.14e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 223029476   297 CTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPL 338
Cdd:smart00215   1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCGPKPCLL 42
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
730-764 3.20e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 36.77  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 223029476   730 TLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVEC 764
Cdd:smart00215   6 SYYPPGAKWDDDCNRCTCLNGRVSCTKVWCGPKPC 40
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 625-656 4.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 4.79e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 223029476 625 DIDECGTGrHSCANDTICFNLDGGYDCRCPHG 656
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPG 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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