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Conserved domains on  [gi|224809576|ref|NP_001139277|]
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immunity-related GTPase family M protein isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IIGP super family cl27085
Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a ...
 6-180 9.80e-77

Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.


The actual alignment was detected with superfamily member pfam05049:

Pssm-ID: 461536 [Multi-domain]  Cd Length: 375  Bit Score: 233.92  E-value: 9.80e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576    6 VEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSN 85
Cdd:pfam05049   8 IEKALREGNLQKVVSIIKKAIQEISSAPLKIAVTGDSGNGKSSFINALRGIGHEEDGSAPTGVVETTMKRTPYSHPHFPN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576   86 VVLWDLPGTGSATTTLENYLMEMQFNRYD-FIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLST------GALP 158
Cdd:pfam05049  88 VVLWDLPGLGATNFTVESYLEEMKFSEYDfFIIISSERFSLNDVKLAKAIQRMGKRFYFVRTKLDSDLSNeqkgkpQTFP 167

                         170       180
                  ....*....|....*....|...
gi 224809576  159 EVQLLQ-IRENVLENLQKERVCE 180
Cdd:pfam05049 168 KEKVLQnIQDNCRNNLQKEGVKE 190
 
Name Accession Description Interval E-value
IIGP pfam05049
Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a ...
 6-180 9.80e-77

Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.


Pssm-ID: 461536 [Multi-domain]  Cd Length: 375  Bit Score: 233.92  E-value: 9.80e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576    6 VEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSN 85
Cdd:pfam05049   8 IEKALREGNLQKVVSIIKKAIQEISSAPLKIAVTGDSGNGKSSFINALRGIGHEEDGSAPTGVVETTMKRTPYSHPHFPN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576   86 VVLWDLPGTGSATTTLENYLMEMQFNRYD-FIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLST------GALP 158
Cdd:pfam05049  88 VVLWDLPGLGATNFTVESYLEEMKFSEYDfFIIISSERFSLNDVKLAKAIQRMGKRFYFVRTKLDSDLSNeqkgkpQTFP 167

                         170       180
                  ....*....|....*....|...
gi 224809576  159 EVQLLQ-IRENVLENLQKERVCE 180
Cdd:pfam05049 168 KEKVLQnIQDNCRNNLQKEGVKE 190
p47_IIGP_like cd04104
p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase ...
 33-180 6.79e-63

p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase family consists of several highly homologous proteins, including IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1. They are found in higher eukaryotes where they play a role in immune resistance against intracellular pathogens. p47 proteins exist at low resting levels in mouse cells, but are strongly induced by Type II interferon (IFN-gamma). ITGP is critical for resistance to Toxoplasma gondii infection and in involved in inhibition of Coxsackievirus-B3-induced apoptosis. TGTP was shown to limit vesicular stomatitis virus (VSV) infection of fibroblasts in vitro. IRG-47 is involved in resistance to T. gondii infection. LRG-47 has been implicated in resistance to T. gondii, Listeria monocytogenes, Leishmania, and mycobacterial infections. IIGP1 has been shown to localize to the ER and to the Golgi membranes in IFN-induced cells and inflamed tissues. In macrophages, IIGP1 interacts with hook3, a microtubule binding protein that participates in the organization of the cis-Golgi compartment.


Pssm-ID: 206690  Cd Length: 197  Bit Score: 192.54  E-value: 6.79e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576  33 PVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNR 112
Cdd:cd04104    1 PLNIAVTGESGAGKSSFINALRGIGHEEEGAAPTGVVETTMKRTPYPHPKFPNVTLWDLPGIGSTAFPPDDYLEEMKFSE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224809576 113 YD-FIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEV------QLLQ-IRENVLENLQKERVCE 180
Cdd:cd04104   81 YDfFIIISSTRFSSNDVKLAKAIQMMGKKFYFVRTKVDSDLSNEQRSKPrsfnkeQVLQqIRDNCLENLQEAGVSE 156
YeeP COG3596
Predicted GTPase [General function prediction only];
4-97 7.48e-03

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 35.90  E-value: 7.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576   4 MNVEKASADGNLP----------EVISNIKETLKIVSRtPVNITMAGDSGNGMSTFISALrnTGHE----GKASPPTelv 69
Cdd:COG3596    1 MSTEVSSLTERLEalkrlpqvlrELLAEALERLLVELP-PPVIALVGKTGAGKSSLINAL--FGAEvaevGVGRPCT--- 74

                         90       100
                 ....*....|....*....|....*...
gi 224809576  70 KATQRCAsYFSSHFSNVVLWDLPGTGSA 97
Cdd:COG3596   75 REIQRYR-LESDGLPGLVLLDTPGLGEV 101
 
Name Accession Description Interval E-value
IIGP pfam05049
Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a ...
 6-180 9.80e-77

Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.


Pssm-ID: 461536 [Multi-domain]  Cd Length: 375  Bit Score: 233.92  E-value: 9.80e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576    6 VEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSN 85
Cdd:pfam05049   8 IEKALREGNLQKVVSIIKKAIQEISSAPLKIAVTGDSGNGKSSFINALRGIGHEEDGSAPTGVVETTMKRTPYSHPHFPN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576   86 VVLWDLPGTGSATTTLENYLMEMQFNRYD-FIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLST------GALP 158
Cdd:pfam05049  88 VVLWDLPGLGATNFTVESYLEEMKFSEYDfFIIISSERFSLNDVKLAKAIQRMGKRFYFVRTKLDSDLSNeqkgkpQTFP 167

                         170       180
                  ....*....|....*....|...
gi 224809576  159 EVQLLQ-IRENVLENLQKERVCE 180
Cdd:pfam05049 168 KEKVLQnIQDNCRNNLQKEGVKE 190
p47_IIGP_like cd04104
p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase ...
 33-180 6.79e-63

p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase family consists of several highly homologous proteins, including IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1. They are found in higher eukaryotes where they play a role in immune resistance against intracellular pathogens. p47 proteins exist at low resting levels in mouse cells, but are strongly induced by Type II interferon (IFN-gamma). ITGP is critical for resistance to Toxoplasma gondii infection and in involved in inhibition of Coxsackievirus-B3-induced apoptosis. TGTP was shown to limit vesicular stomatitis virus (VSV) infection of fibroblasts in vitro. IRG-47 is involved in resistance to T. gondii infection. LRG-47 has been implicated in resistance to T. gondii, Listeria monocytogenes, Leishmania, and mycobacterial infections. IIGP1 has been shown to localize to the ER and to the Golgi membranes in IFN-induced cells and inflamed tissues. In macrophages, IIGP1 interacts with hook3, a microtubule binding protein that participates in the organization of the cis-Golgi compartment.


Pssm-ID: 206690  Cd Length: 197  Bit Score: 192.54  E-value: 6.79e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576  33 PVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNR 112
Cdd:cd04104    1 PLNIAVTGESGAGKSSFINALRGIGHEEEGAAPTGVVETTMKRTPYPHPKFPNVTLWDLPGIGSTAFPPDDYLEEMKFSE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224809576 113 YD-FIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEV------QLLQ-IRENVLENLQKERVCE 180
Cdd:cd04104   81 YDfFIIISSTRFSSNDVKLAKAIQMMGKKFYFVRTKVDSDLSNEQRSKPrsfnkeQVLQqIRDNCLENLQEAGVSE 156
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 39-151 1.06e-04

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 40.90  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576  39 AGDSGNGMSTFISAL--RNTGHEGKASPPTelvKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYD-F 115
Cdd:cd00882    3 VGRGGVGKSSLLNALlgGEVGEVSDVPGTT---RDPDVYVKELDKGKVKLVLVDTPGLDEFGGLGREELARLLLRGADlI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 224809576 116 IMVASAQ----FSMNHVMLAKTAEDMGKKFYIVWTKLDMD 151
Cdd:cd00882   80 LLVVDSTdresEEDAKLLILRRLRKEGIPIILVGNKIDLL 119
YeeP COG3596
Predicted GTPase [General function prediction only];
4-97 7.48e-03

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 35.90  E-value: 7.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809576   4 MNVEKASADGNLP----------EVISNIKETLKIVSRtPVNITMAGDSGNGMSTFISALrnTGHE----GKASPPTelv 69
Cdd:COG3596    1 MSTEVSSLTERLEalkrlpqvlrELLAEALERLLVELP-PPVIALVGKTGAGKSSLINAL--FGAEvaevGVGRPCT--- 74

                         90       100
                 ....*....|....*....|....*...
gi 224809576  70 KATQRCAsYFSSHFSNVVLWDLPGTGSA 97
Cdd:COG3596   75 REIQRYR-LESDGLPGLVLLDTPGLGEV 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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