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Conserved domains on  [gi|226443152|ref|NP_001139786|]
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putative protein-lysine deacylase ABHD14B isoform 1 [Homo sapiens]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 8-209 3.32e-25

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 97.76  E-value: 3.32e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152   8 REGTIQVQGQALFFREAlpgsGQARFSVLLLHGIRFSSETWQNLgtLHRLAqAGYRAVAIDLPGLGHSKEAAAPAPIGEL 87
Cdd:COG0596    3 TPRFVTVDGVRLHYREA----GPDGPPVVLLHGLPGSSYEWRPL--IPALA-AGYRVIAPDLRGHGRSDKPAGGYTLDDL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  88 ApgSFLAAVVDALELGPPVVISPSLSGMYSLPF------------------------LTAPGSQLPGFVPVAPICTDKIN 143
Cdd:COG0596   76 A--DDLAALLDALGLERVVLVGHSMGGMVALELaarhpervaglvlvdevlaalaepLRRPGLAPEALAALLRALARTDL 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226443152 144 AANYASVKTPALIVYGDQDPMG--QTSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGL 209
Cdd:COG0596  154 RERLARITVPTLVIWGEKDPIVppALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 8-209 3.32e-25

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 97.76  E-value: 3.32e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152   8 REGTIQVQGQALFFREAlpgsGQARFSVLLLHGIRFSSETWQNLgtLHRLAqAGYRAVAIDLPGLGHSKEAAAPAPIGEL 87
Cdd:COG0596    3 TPRFVTVDGVRLHYREA----GPDGPPVVLLHGLPGSSYEWRPL--IPALA-AGYRVIAPDLRGHGRSDKPAGGYTLDDL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  88 ApgSFLAAVVDALELGPPVVISPSLSGMYSLPF------------------------LTAPGSQLPGFVPVAPICTDKIN 143
Cdd:COG0596   76 A--DDLAALLDALGLERVVLVGHSMGGMVALELaarhpervaglvlvdevlaalaepLRRPGLAPEALAALLRALARTDL 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226443152 144 AANYASVKTPALIVYGDQDPMG--QTSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGL 209
Cdd:COG0596  154 RERLARITVPTLVIWGEKDPIVppALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 11-114 2.08e-06

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 47.25  E-value: 2.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  11 TIQVQGQALFFREALPGSGQArfsVLLLHGirFSSE--TWqnLGTLHRLAqAGYRAVAIDLPGLGHSKEAAAPAPIGELA 88
Cdd:PRK14875 113 KARIGGRTVRYLRLGEGDGTP---VVLIHG--FGGDlnNW--LFNHAALA-AGRPVIALDLPGHGASSKAVGAGSLDELA 184

                         90       100
                 ....*....|....*....|....*.
gi 226443152  89 pgSFLAAVVDALELGPPVVISPSLSG 114
Cdd:PRK14875 185 --AAVLAFLDALGIERAHLVGHSMGG 208
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 35-115 1.24e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 41.72  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152   35 VLLLHGIRFSSETWQNLGTLhrLAQAGYRAVAIDLPGLGHSKEAAAPAPIGELAPGSFLAAVVDALELGPPVVISPSLSG 114
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKLAPA--LARDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80


                  .
gi 226443152  115 M 115
Cdd:pfam00561  81 L 81
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 35-100 9.08e-04

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 39.12  E-value: 9.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226443152   35 VLLLHGIRFSSETWQNLgtLHRLAQaGYRAVAIDLPGLGHSKEaaapapIGELAPGSFLAAVVDAL 100
Cdd:TIGR03695   5 LVFLHGFLGSGADWQAL--IEALGP-HFRCLAIDLPGHGSSQS------PSDIERYDFEEAAQLLL 61
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 8-209 3.32e-25

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 97.76  E-value: 3.32e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152   8 REGTIQVQGQALFFREAlpgsGQARFSVLLLHGIRFSSETWQNLgtLHRLAqAGYRAVAIDLPGLGHSKEAAAPAPIGEL 87
Cdd:COG0596    3 TPRFVTVDGVRLHYREA----GPDGPPVVLLHGLPGSSYEWRPL--IPALA-AGYRVIAPDLRGHGRSDKPAGGYTLDDL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  88 ApgSFLAAVVDALELGPPVVISPSLSGMYSLPF------------------------LTAPGSQLPGFVPVAPICTDKIN 143
Cdd:COG0596   76 A--DDLAALLDALGLERVVLVGHSMGGMVALELaarhpervaglvlvdevlaalaepLRRPGLAPEALAALLRALARTDL 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226443152 144 AANYASVKTPALIVYGDQDPMG--QTSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGL 209
Cdd:COG0596  154 RERLARITVPTLVIWGEKDPIVppALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
16-207 1.63e-15

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 71.96  E-value: 1.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  16 GQALFFREALPgSGQARFSVLLLHGIRFSSETWQNLGtlHRLAQAGYRAVAIDLPGLGHSkeaaaPAPIGELApgSF--- 92
Cdd:COG2267   13 GLRLRGRRWRP-AGSPRGTVVLVHGLGEHSGRYAELA--EALAAAGYAVLAFDLRGHGRS-----DGPRGHVD--SFddy 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  93 ---LAAVVDALEL---GPPVVISPSLSGMYSLPFLTAPGSQLPGFVPVAP-ICTDKIN------------AANYASVKTP 153
Cdd:COG2267   83 vddLRAALDALRArpgLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPaYRADPLLgpsarwlralrlAEALARIDVP 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152 154 ALIVYGDQDPmgQTSFEHLKQL-----PNHRVLIMKGAGHPCYLDKP-EEWHTGLLDFLQ 207
Cdd:COG2267  163 VLVLHGGADR--VVPPEAARRLaarlsPDVELVLLPGARHELLNEPArEEVLAAILAWLE 220
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
24-188 2.82e-09

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 54.97  E-value: 2.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  24 ALPGSGQARFSVLLLHGIRFSSEtwQNLGTLHRLAQAGYRAVAIDL--PGLGHSKEAAAPAPIGELAPGSFLA---AVVD 98
Cdd:COG0412   21 ARPAGGGPRPGVVVLHEIFGLNP--HIRDVARRLAAAGYVVLAPDLygRGGPGDDPDEARALMGALDPELLAAdlrAALD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  99 ALELGPPVVISP------SLSGMYSLpFLTAPGSQLPGFVPVAPICTDKINAANYASVKTPALIVYGDQDPMgqTSFEHL 172
Cdd:COG0412   99 WLKAQPEVDAGRvgvvgfCFGGGLAL-LAAARGPDLAAAVSFYGGLPADDLLDLAARIKAPVLLLYGEKDPL--VPPEQV 175

                        170       180
                 ....*....|....*....|....
gi 226443152 173 KQL--------PNHRVLIMKGAGH 188
Cdd:COG0412  176 AALeaalaaagVDVELHVYPGAGH 199
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
32-209 3.33e-07

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 49.17  E-value: 3.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  32 RFSVLLLHGIRFSSETWQNLGtlHRLAQAGYRAVAIDLPGLGHSKEAAApapigELAPGSFLAAVVDALELG-----PPV 106
Cdd:COG1647   15 RKGVLLLHGFTGSPAEMRPLA--EALAKAGYTVYAPRLPGHGTSPEDLL-----KTTWEDWLEDVEEAYEILkagydKVI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152 107 VISPSLSGMYSL----------------PFLTAPGSQLPgFVPVAPICTDKINA-------------------------- 144
Cdd:COG1647   88 VIGLSMGGLLALllaarypdvaglvllsPALKIDDPSAP-LLPLLKYLARSLRGigsdiedpevaeyaydrtplralael 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226443152 145 --------ANYASVKTPALIVYGDQDPM-----GQTSFEHLKQlPNHRVLIMKGAGHPCYLDK-PEEWHTGLLDFLQGL 209
Cdd:COG1647  167 qrlirevrRDLPKITAPTLIIQSRKDEVvppesARYIYERLGS-PDKELVWLEDSGHVITLDKdREEVAEEILDFLERL 244
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 11-114 2.08e-06

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 47.25  E-value: 2.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  11 TIQVQGQALFFREALPGSGQArfsVLLLHGirFSSE--TWqnLGTLHRLAqAGYRAVAIDLPGLGHSKEAAAPAPIGELA 88
Cdd:PRK14875 113 KARIGGRTVRYLRLGEGDGTP---VVLIHG--FGGDlnNW--LFNHAALA-AGRPVIALDLPGHGASSKAVGAGSLDELA 184

                         90       100
                 ....*....|....*....|....*.
gi 226443152  89 pgSFLAAVVDALELGPPVVISPSLSG 114
Cdd:PRK14875 185 --AAVLAFLDALGIERAHLVGHSMGG 208
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 35-207 9.60e-06

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 44.91  E-value: 9.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  35 VLLLHGIRFSSETWQNLGtlHRLAQAGYRAVAIDLPGLGHSkeAAAPAPIGELAPGSFLAAV--------VDALELGppv 106
Cdd:COG1073   40 VVVAHGNGGVKEQRALYA--QRLAELGFNVLAFDYRGYGES--EGEPREEGSPERRDARAAVdylrtlpgVDPERIG--- 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152 107 VISPSLSGMYSL----------------PFL-----------TAPGSQLPGF-----VPVAPICTDKINAANYAS-VKTP 153
Cdd:COG1073  113 LLGISLGGGYALnaaatdprvkavildsPFTsledlaaqrakEARGAYLPGVpylpnVRLASLLNDEFDPLAKIEkISRP 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152 154 ALIVYGDQDP-----MGQTSFEHLKQlpNHRVLIMKGAGH-PCYLDKPEEWHTGLLDFLQ 207
Cdd:COG1073  193 LLFIHGEKDEavpfyMSEDLYEAAAE--PKELLIVPGAGHvDLYDRPEEEYFDKLAEFFK 250
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
35-206 1.06e-04

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 41.93  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  35 VLLLHGIRFSSEtWQNLGTLHRLAQAGYRAVAIDLPGLGHSKEAAAPAPIGELApgsflaAVVDALELGPPV-------- 106
Cdd:COG1506   26 VVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVL------AAIDYLAARPYVdpdrigiy 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152 107 ----------------------VISpsLSGMYSLPFLTAPGSQLPGFVPVAPICT----DKINAANYA-SVKTPALIVYG 159
Cdd:COG1506   99 ghsyggymallaaarhpdrfkaAVA--LAGVSDLRSYYGTTREYTERLMGGPWEDpeayAARSPLAYAdKLKTPLLLIHG 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 226443152 160 DQDP-----MGQTSFEHLKQL-PNHRVLIMKGAGHPCYLDKPEEWHTGLLDFL 206
Cdd:COG1506  177 EADDrvppeQAERLYEALKKAgKPVELLVYPGEGHGFSGAGAPDYLERILDFL 229
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 35-115 1.24e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 41.72  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152   35 VLLLHGIRFSSETWQNLGTLhrLAQAGYRAVAIDLPGLGHSKEAAAPAPIGELAPGSFLAAVVDALELGPPVVISPSLSG 114
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKLAPA--LARDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80


                  .
gi 226443152  115 M 115
Cdd:pfam00561  81 L 81
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 35-100 1.83e-04

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 39.43  E-value: 1.83e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226443152  35 VLLLHGIRFSSETWQNLGtlHRLAQAGYRAVAIDLPGLGHSKEAAAPApigelapgsfLAAVVDAL 100
Cdd:COG1075    8 VVLVHGLGGSAASWAPLA--PRLRAAGYPVYALNYPSTNGSIEDSAEQ----------LAAFVDAV 61
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 35-118 2.62e-04

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 40.53  E-value: 2.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152   35 VLLLHGirfsseTWQNLGTLHRLAQAGYRAVAIDLPGLGHSkeAAAPAPIGELApgSFLAAVVDALELGPPVVISPSLSG 114
Cdd:pfam12697   1 VVLVHG------AGLSAAPLAALLAAGVAVLAPDLPGHGSS--SPPPLDLADLA--DLAALLDELGAARPVVLVGHSLGG 70


                  ....
gi 226443152  115 MYSL 118
Cdd:pfam12697  71 AVAL 74
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 35-100 9.08e-04

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 39.12  E-value: 9.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226443152   35 VLLLHGIRFSSETWQNLgtLHRLAQaGYRAVAIDLPGLGHSKEaaapapIGELAPGSFLAAVVDAL 100
Cdd:TIGR03695   5 LVFLHGFLGSGADWQAL--IEALGP-HFRCLAIDLPGHGSSQS------PSDIERYDFEEAAQLLL 61
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 16-142 1.72e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 38.60  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  16 GQALFFREALP-GSGQARFSVLLLHGI-RFSSETWQNLGTLhrLAQAGYRAVAIDLPGLGHSKEAAAPAPIGELAPG--- 90
Cdd:PLN02298  42 GLSLFTRSWLPsSSSPPRALIFMVHGYgNDISWTFQSTAIF--LAQMGFACFALDLEGHGRSEGLRAYVPNVDLVVEdcl 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 226443152  91 SFLAAVVDALELG--PPVVISPSLSGMYSLPFLTAPGSQLPGFVPVAPIC--TDKI 142
Cdd:PLN02298 120 SFFNSVKQREEFQglPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCkiSDKI 175
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
35-105 3.17e-03

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 37.82  E-value: 3.17e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226443152  35 VLLLHGIRFSSETWQNLGTLHRLAQAGYRAVAIDLPglGHSKEAaapapigELAPGSF-------LAAVVDAL-ELGPP 105
Cdd:COG0429   64 VVLLHGLEGSSDSHYARGLARALYARGWDVVRLNFR--GCGGEP-------NLLPRLYhsgdtedLVWVLAHLrARYPY 133
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 150-209 4.61e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 37.13  E-value: 4.61e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226443152 150 VKTPALIVYGDQD-------PMGQTSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGL 209
Cdd:PLN02679 291 ISLPILVLWGDQDpftpldgPVGKYFSSLPSQLPNVTLYVLEGVGHCPHDDRPDLVHEKLLPWLAQL 357
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 11-102 8.18e-03

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 36.51  E-value: 8.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443152  11 TIQVQGQALFFREAlpGSGQArfsVLLLHGIRFSSETWQNLgtLHRLAQAGyRAVAIDLPGLGHSKEAAAPAPIGELApg 90
Cdd:PRK03592  11 RVEVLGSRMAYIET--GEGDP---IVFLHGNPTSSYLWRNI--IPHLAGLG-RCLAPDLIGMGASDKPDIDYTFADHA-- 80

                         90
                 ....*....|..
gi 226443152  91 SFLAAVVDALEL 102
Cdd:PRK03592  81 RYLDAWFDALGL 92
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 35-75 8.20e-03

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 36.48  E-value: 8.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 226443152  35 VLLLHGirfsSETWqnlGTLHR-----LAQAGYRAVAIDLPGLGHS 75
Cdd:PRK00870  49 VLLLHG----EPSW---SYLYRkmipiLAAAGHRVIAPDLIGFGRS 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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