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Conserved domains on  [gi|226437599|ref|NP_001139811|]
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V-set and transmembrane domain-containing protein 2B isoform 1 precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|10436082

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-139 8.42e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 54.43  E-value: 8.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599    34 PKDVTVREGDDIEMPCafRASGATSYSLeiqWWYlKEPPRELLHElalsvpgarskvtnkdatkiSTVRVQGNDISHRLR 113
Cdd:smart00410   1 PPSVTVKEGESVTLSC--EASGSPPPEV---TWY-KQGGKLLAES--------------------GRFSVSRSGSTSTLT 54

                           90       100
                   ....*....|....*....|....*.
gi 226437599   114 LSAVRLQDEGVYECRVSDYSDDDTQE 139
Cdd:smart00410  55 ISNVTPEDSGTYTCAATNSSGSASSG 80
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-139 8.42e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 54.43  E-value: 8.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599    34 PKDVTVREGDDIEMPCafRASGATSYSLeiqWWYlKEPPRELLHElalsvpgarskvtnkdatkiSTVRVQGNDISHRLR 113
Cdd:smart00410   1 PPSVTVKEGESVTLSC--EASGSPPPEV---TWY-KQGGKLLAES--------------------GRFSVSRSGSTSTLT 54

                           90       100
                   ....*....|....*....|....*.
gi 226437599   114 LSAVRLQDEGVYECRVSDYSDDDTQE 139
Cdd:smart00410  55 ISNVTPEDSGTYTCAATNSSGSASSG 80
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 32-149 9.17e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 49.38  E-value: 9.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599   32 EVPKDVTVREGDDIEMPCAFRasgaTSYSLEIQW--WYLKEPPRELLHELALSVPGARSKVTnKDATKISTVRVQGnDIS 109
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYS----SSMSEASTSvyWYRQPPGKGPTFLIAYYSNGSEEGVK-KGRFSGRGDPSNG-DGS 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 226437599  110 hrLRLSAVRLQDEGVYECRVsDYSDDDTQEHKAQamLRVL 149
Cdd:pfam07686  75 --LTIQNLTLSDSGTYTCAV-IPSGEGVFGKGTR--LTVL 109
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 31-136 3.39e-05

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 42.12  E-value: 3.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599  31 TEVPKDVTVREGDDIEMPCAFRasgaTSYSLEIQWWYlKEPPRellHELALSVPGArSKVTNKDATKIStVRVQGNDISH 110
Cdd:cd07706    3 TQAQPDVSVQVGEEVTLNCRYE----TSWTNYYLFWY-KQLPS---GEMTFLIRQD-SSEQNAKSGRYS-VNFQKAQKSI 72

                         90       100
                 ....*....|....*....|....*.
gi 226437599 111 RLRLSAVRLQDEGVYECRVSDYSDDD 136
Cdd:cd07706   73 SLTISALQLEDSAKYFCALSLPYDTD 98
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-139 8.42e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 54.43  E-value: 8.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599    34 PKDVTVREGDDIEMPCafRASGATSYSLeiqWWYlKEPPRELLHElalsvpgarskvtnkdatkiSTVRVQGNDISHRLR 113
Cdd:smart00410   1 PPSVTVKEGESVTLSC--EASGSPPPEV---TWY-KQGGKLLAES--------------------GRFSVSRSGSTSTLT 54

                           90       100
                   ....*....|....*....|....*.
gi 226437599   114 LSAVRLQDEGVYECRVSDYSDDDTQE 139
Cdd:smart00410  55 ISNVTPEDSGTYTCAATNSSGSASSG 80
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 32-149 9.17e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 49.38  E-value: 9.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599   32 EVPKDVTVREGDDIEMPCAFRasgaTSYSLEIQW--WYLKEPPRELLHELALSVPGARSKVTnKDATKISTVRVQGnDIS 109
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYS----SSMSEASTSvyWYRQPPGKGPTFLIAYYSNGSEEGVK-KGRFSGRGDPSNG-DGS 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 226437599  110 hrLRLSAVRLQDEGVYECRVsDYSDDDTQEHKAQamLRVL 149
Cdd:pfam07686  75 --LTIQNLTLSDSGTYTCAV-IPSGEGVFGKGTR--LTVL 109
I-set pfam07679
Immunoglobulin I-set domain;
30-130 4.60e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 46.87  E-value: 4.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599   30 FTEVPKDVTVREGDDIEMPCafRASGATSysLEIQWWYLKEPPRellhelalsvPGARSKVTNKDATkistvrvqgndis 109
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTC--TVTGTPD--PEVSWFKDGQPLR----------SSDRFKVTYEGGT------------- 55

                          90       100
                  ....*....|....*....|.
gi 226437599  110 HRLRLSAVRLQDEGVYECRVS 130
Cdd:pfam07679  56 YTLTISNVQPDDSGKYTCVAT 76
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 31-136 3.39e-05

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 42.12  E-value: 3.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599  31 TEVPKDVTVREGDDIEMPCAFRasgaTSYSLEIQWWYlKEPPRellHELALSVPGArSKVTNKDATKIStVRVQGNDISH 110
Cdd:cd07706    3 TQAQPDVSVQVGEEVTLNCRYE----TSWTNYYLFWY-KQLPS---GEMTFLIRQD-SSEQNAKSGRYS-VNFQKAQKSI 72

                         90       100
                 ....*....|....*....|....*.
gi 226437599 111 RLRLSAVRLQDEGVYECRVSDYSDDD 136
Cdd:cd07706   73 SLTISALQLEDSAKYFCALSLPYDTD 98
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 34-130 5.22e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.01  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599   34 PKDVTVREGDDIEMPCAFRASGATSYsleiqWWYlkepprellhelalsvpgarskvtnKDATKISTVRVQGNDISH--- 110
Cdd:pfam13927   8 PSSVTVREGETVTLTCEATGSPPPTI-----TWY-------------------------KNGEPISSGSTRSRSLSGsns 57

                          90       100
                  ....*....|....*....|
gi 226437599  111 RLRLSAVRLQDEGVYECRVS 130
Cdd:pfam13927  58 TLTISNVTRSDAGTYTCVAS 77
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 28-134 2.73e-04

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 39.95  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599  28 AAFTEVPKDVTVREGDDIEMPCAFRASGATsyslEIQWWYLKEPPRELLHELalsVPGARSKVTNKDATKIstvrvqgND 107
Cdd:cd20940    1 AGFIKSPLSQQRLVGDSVELHCEAVGSPIP----EIQWWFEGQEPNEICSQL---WDGARLDRVHINATYH-------QH 66

                         90       100
                 ....*....|....*....|....*..
gi 226437599 108 ISHRLRLSAVRLQDEGVYECRVSDYSD 134
Cdd:cd20940   67 ATSTISIDNLTEEDTGTYECRASNDPD 93
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 33-131 2.85e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 36.02  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599   33 VPKDVTVREGDDIEMPCafRASGATSYsLEIQWWylkepprellhelalsvpgaRSKVTNKDATKIstVRVQGNDISHRL 112
Cdd:pfam00047   2 APPTVTVLEGDSATLTC--SASTGSPG-PDVTWS--------------------KEGGTLIESLKV--KHDNGRTTQSSL 56

                          90
                  ....*....|....*....
gi 226437599  113 RLSAVRLQDEGVYECRVSD 131
Cdd:pfam00047  57 LISNVTKEDAGTYTCVVNN 75
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 32-137 3.15e-03

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 36.53  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599  32 EVPKDVTVREGDDIEMPCAFR--ASGATSYSLEIQWWylKEPPRELLHELALSVPGARSKVTNKDATKISTVRVQGNDIS 109
Cdd:cd05877    2 TVQAKVFSHRGGNVTLPCRYHyePELSAPRKIRVKWT--KLEVDYAKEEDVLVAIGTRHKSYGSYQGRVFLRRADDLDAS 79

                         90       100
                 ....*....|....*....|....*...
gi 226437599 110 hrLRLSAVRLQDEGVYECRVSDYSDDDT 137
Cdd:cd05877   80 --LVITDLRLEDYGRYRCEVIDGLEDES 105
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 28-129 4.90e-03

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 36.11  E-value: 4.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599  28 AAFTEVPKDVTVREGDDIEMPCAFRASGATSYSLEIQWWYLKEPPREllhELALSVPGARSKVTNKDATKIStvrvqgND 107
Cdd:cd20926    1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGK---EVRNGTPEFRGRLAPLASSRFL------RD 71

                         90       100
                 ....*....|....*....|..
gi 226437599 108 ISHRLRLSAVRLQDEGVYECRV 129
Cdd:cd20926   72 HQAELHIWDVRGHDAGIYVCRV 93
IGv smart00406
Immunoglobulin V-Type;
44-127 7.04e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 35.05  E-value: 7.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599    44 DIEMPCafRASGATSYSLEIQWwyLKEPPRELLhELALSVPgarSKVTNKDATKISTvRVQGNDISHR----LRLSAVRL 119
Cdd:smart00406   1 SVTLSC--KFSGSTFSSYYVSW--VRQPPGKGL-EWLGYIG---SNGSSYYQESYKG-RFTISKDTSKndvsLTISNLRV 71


                   ....*...
gi 226437599   120 QDEGVYEC 127
Cdd:smart00406  72 EDTGTYYC 79
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 32-133 7.64e-03

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 35.66  E-value: 7.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437599  32 EVPKD-VTVREGDDIEMPCAFRASGATSYSLEIQWWYLKEPPReLLHELALSVPGARSKVTN-KDATKI-STVRVQGNdi 108
Cdd:cd20934    1 RVPEDpVVALVGTDATLRCSFSPEPGFSLAQLSVFWQLTDTKQ-LVHSFTESQDQGRDQGSAyANRTALfPDLLAQGN-- 77

                         90       100
                 ....*....|....*....|....*..
gi 226437599 109 sHRLRLSAVRLQDEGVYEC--RVSDYS 133
Cdd:cd20934   78 -ASLRLQRVRVADEGSYTCfvSVQDFG 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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