NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|238479928|ref|NP_001154652|]
View 

receptor like protein 43 [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000136)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 16-631 3.23e-85

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 289.06  E-value: 3.23e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928  16 SFIFLFISqfSDVLAAptrhlcrpEQKDALLKFKTEfeIGKPCRYCTvyciephpkteSWgNNNSDCCNWEGVTCNaKSG 95
Cdd:PLN00113  15 MLFFLFLN--FSMLHA--------EELELLLSFKSS--INDPLKYLS-----------NW-NSSADVCLWQGITCN-NSS 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928  96 EVIELDLSCSYLHGR-----------------------------FHSNSSIRNLHF----------------LTTLDLSF 130
Cdd:PLN00113  70 RVVSIDLSGKNISGKissaifrlpyiqtinlsnnqlsgpipddiFTTSSSLRYLNLsnnnftgsiprgsipnLETLDLSN 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 131 NDFKGQIMSSIENLSHLTYLDLSFNHFSGQVPSSIGNLSHLTFLDLYCNQFSGQVPSSIGNLSHLTTLELSFNRFFGQFP 210
Cdd:PLN00113 150 NMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIP 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 211 SSIGGLSHLTTLNLFVNNFLGQIPSSIGNLSNLTSLYLCKNNFSGQIPSFIGNLSQLTRLDLSSNNFFGEIPGWLWTLPN 290
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQN 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 291 LfyvnlsyntfigfqrpnkpepSMGHLLgsNNNFTGKIPSFICELRSLETLDLSDNNFSGLIPRCMGNlKSNLSHLNLRQ 370
Cdd:PLN00113 310 L---------------------EILHLF--SNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGK-HNNLTVLDLST 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 371 NNLSGGLPK------HIFE-ILRSldvghNQLVGKLPRSLRFFSTLEVLNVESNRINDTFPFWLTSLPKLQVLVLRSNAF 443
Cdd:PLN00113 366 NNLTGEIPEglcssgNLFKlILFS-----NSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 444 HGPIHEASF--LKLRIIDISHNHFNGTLPSdyfvkwSAMSSLGTDEDRSNANYMGsvyyqdsMVLMNKGVESELIRilti 521
Cdd:PLN00113 441 QGRINSRKWdmPSLQMLSLARNKFFGGLPD------SFGSKRLENLDLSRNQFSG-------AVPRKLGSLSELMQ---- 503

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 522 ytaLDFSGNKFEGEIPKSIGLLKELLVLNLSNNAFTGHIPSSMGKLTALESLDVSQNKLYGEIPQEIGNLSFLSCMNFSH 601
Cdd:PLN00113 504 ---LKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISH 580

                        650       660       670
                 ....*....|....*....|....*....|
gi 238479928 602 NQLAGLVPGGQQFLTQPCSSFEDNLGLFGS 631
Cdd:PLN00113 581 NHLHGSLPSTGAFLAINASAVAGNIDLCGG 610
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 16-631 3.23e-85

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 289.06  E-value: 3.23e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928  16 SFIFLFISqfSDVLAAptrhlcrpEQKDALLKFKTEfeIGKPCRYCTvyciephpkteSWgNNNSDCCNWEGVTCNaKSG 95
Cdd:PLN00113  15 MLFFLFLN--FSMLHA--------EELELLLSFKSS--INDPLKYLS-----------NW-NSSADVCLWQGITCN-NSS 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928  96 EVIELDLSCSYLHGR-----------------------------FHSNSSIRNLHF----------------LTTLDLSF 130
Cdd:PLN00113  70 RVVSIDLSGKNISGKissaifrlpyiqtinlsnnqlsgpipddiFTTSSSLRYLNLsnnnftgsiprgsipnLETLDLSN 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 131 NDFKGQIMSSIENLSHLTYLDLSFNHFSGQVPSSIGNLSHLTFLDLYCNQFSGQVPSSIGNLSHLTTLELSFNRFFGQFP 210
Cdd:PLN00113 150 NMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIP 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 211 SSIGGLSHLTTLNLFVNNFLGQIPSSIGNLSNLTSLYLCKNNFSGQIPSFIGNLSQLTRLDLSSNNFFGEIPGWLWTLPN 290
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQN 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 291 LfyvnlsyntfigfqrpnkpepSMGHLLgsNNNFTGKIPSFICELRSLETLDLSDNNFSGLIPRCMGNlKSNLSHLNLRQ 370
Cdd:PLN00113 310 L---------------------EILHLF--SNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGK-HNNLTVLDLST 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 371 NNLSGGLPK------HIFE-ILRSldvghNQLVGKLPRSLRFFSTLEVLNVESNRINDTFPFWLTSLPKLQVLVLRSNAF 443
Cdd:PLN00113 366 NNLTGEIPEglcssgNLFKlILFS-----NSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 444 HGPIHEASF--LKLRIIDISHNHFNGTLPSdyfvkwSAMSSLGTDEDRSNANYMGsvyyqdsMVLMNKGVESELIRilti 521
Cdd:PLN00113 441 QGRINSRKWdmPSLQMLSLARNKFFGGLPD------SFGSKRLENLDLSRNQFSG-------AVPRKLGSLSELMQ---- 503

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 522 ytaLDFSGNKFEGEIPKSIGLLKELLVLNLSNNAFTGHIPSSMGKLTALESLDVSQNKLYGEIPQEIGNLSFLSCMNFSH 601
Cdd:PLN00113 504 ---LKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISH 580

                        650       660       670
                 ....*....|....*....|....*....|
gi 238479928 602 NQLAGLVPGGQQFLTQPCSSFEDNLGLFGS 631
Cdd:PLN00113 581 NHLHGSLPSTGAFLAINASAVAGNIDLCGG 610
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-434 7.02e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.45  E-value: 7.02e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 114 NSSIRNLHFLTTLDLSFNDfkgqimsSIENLSHLTYLDLSFNHFSgQVPSSIGNLSHLTFLDLYCNQFSgQVPSSIGNLS 193
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 194 HLTTLELSFNRFfGQFPSSIGGLSHLTTLNLFvNNFLGQIPSSIGNLSNLTSLYLCKNNFSgQIPSFIGNLSQLTRLDLS 273
Cdd:COG4886  160 NLKSLDLSNNQL-TDLPEELGNLTNLKELDLS-NNQITDLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 274 SNNfFGEIPgWLWTLPNLFYVNLSYNTFIGFqrpnkpepsmghllgsnnnftgkipSFICELRSLETLDLSDNNFSGL-I 352
Cdd:COG4886  237 NNQ-LTDLP-ELGNLTNLEELDLSNNQLTDL-------------------------PPLANLTNLKTLDLSNNQLTDLkL 289

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 353 PRCMGNLKSNLSHLNLRQNNLSGGLPKHIFEILRSLDVGHNQLVGKLPRSLRFFSTLEVLNVESNRINDTFPFWLTSLPK 432
Cdd:COG4886  290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369


                 ..
gi 238479928 433 LQ 434
Cdd:COG4886  370 GL 371
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 39-91 2.29e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 56.15  E-value: 2.29e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 238479928   39 PEQKDALLKFKTEFeigkpcryctvycIEPHPKTESWGNNNSDCCNWEGVTCN 91
Cdd:pfam08263   2 NDDGQALLAFKSSL-------------NDPPGALSSWNSSSSDPCSWTGVTCD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 189-371 8.05e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 189 IGNLSHLttlelSFNrffGQFPSSIGGLSH---LTTLNLFvNNFLGQIPSsIGNLSNLTSLYLcKNNFSGQIPSFiGNLS 265
Cdd:cd21340    1 LKRITHL-----YLN---DKNITKIDNLSLcknLKVLYLY-DNKITKIEN-LEFLTNLTHLYL-QNNQIEKIENL-ENLV 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 266 QLTRLDLSsNNFFGEIPGwLWTLPNLFYVNLSYntfigfQRPNKPEP------SMGHLLG-------SNNNFTgkIPSFI 332
Cdd:cd21340   69 NLKKLYLG-GNRISVVEG-LENLTNLEELHIEN------QRLPPGEKltfdprSLAALSNslrvlniSGNNID--SLEPL 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 238479928 333 CELRSLETLDLSDNNFSGL--IPRCMGNLKSnLSHLNLRQN 371
Cdd:cd21340  139 APLRNLEQLDASNNQISDLeeLLDLLSSWPS-LRELDLTGN 178
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 16-631 3.23e-85

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 289.06  E-value: 3.23e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928  16 SFIFLFISqfSDVLAAptrhlcrpEQKDALLKFKTEfeIGKPCRYCTvyciephpkteSWgNNNSDCCNWEGVTCNaKSG 95
Cdd:PLN00113  15 MLFFLFLN--FSMLHA--------EELELLLSFKSS--INDPLKYLS-----------NW-NSSADVCLWQGITCN-NSS 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928  96 EVIELDLSCSYLHGR-----------------------------FHSNSSIRNLHF----------------LTTLDLSF 130
Cdd:PLN00113  70 RVVSIDLSGKNISGKissaifrlpyiqtinlsnnqlsgpipddiFTTSSSLRYLNLsnnnftgsiprgsipnLETLDLSN 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 131 NDFKGQIMSSIENLSHLTYLDLSFNHFSGQVPSSIGNLSHLTFLDLYCNQFSGQVPSSIGNLSHLTTLELSFNRFFGQFP 210
Cdd:PLN00113 150 NMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIP 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 211 SSIGGLSHLTTLNLFVNNFLGQIPSSIGNLSNLTSLYLCKNNFSGQIPSFIGNLSQLTRLDLSSNNFFGEIPGWLWTLPN 290
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQN 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 291 LfyvnlsyntfigfqrpnkpepSMGHLLgsNNNFTGKIPSFICELRSLETLDLSDNNFSGLIPRCMGNlKSNLSHLNLRQ 370
Cdd:PLN00113 310 L---------------------EILHLF--SNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGK-HNNLTVLDLST 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 371 NNLSGGLPK------HIFE-ILRSldvghNQLVGKLPRSLRFFSTLEVLNVESNRINDTFPFWLTSLPKLQVLVLRSNAF 443
Cdd:PLN00113 366 NNLTGEIPEglcssgNLFKlILFS-----NSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 444 HGPIHEASF--LKLRIIDISHNHFNGTLPSdyfvkwSAMSSLGTDEDRSNANYMGsvyyqdsMVLMNKGVESELIRilti 521
Cdd:PLN00113 441 QGRINSRKWdmPSLQMLSLARNKFFGGLPD------SFGSKRLENLDLSRNQFSG-------AVPRKLGSLSELMQ---- 503

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 522 ytaLDFSGNKFEGEIPKSIGLLKELLVLNLSNNAFTGHIPSSMGKLTALESLDVSQNKLYGEIPQEIGNLSFLSCMNFSH 601
Cdd:PLN00113 504 ---LKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISH 580

                        650       660       670
                 ....*....|....*....|....*....|
gi 238479928 602 NQLAGLVPGGQQFLTQPCSSFEDNLGLFGS 631
Cdd:PLN00113 581 NHLHGSLPSTGAFLAINASAVAGNIDLCGG 610
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-434 7.02e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.45  E-value: 7.02e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 114 NSSIRNLHFLTTLDLSFNDfkgqimsSIENLSHLTYLDLSFNHFSgQVPSSIGNLSHLTFLDLYCNQFSgQVPSSIGNLS 193
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 194 HLTTLELSFNRFfGQFPSSIGGLSHLTTLNLFvNNFLGQIPSSIGNLSNLTSLYLCKNNFSgQIPSFIGNLSQLTRLDLS 273
Cdd:COG4886  160 NLKSLDLSNNQL-TDLPEELGNLTNLKELDLS-NNQITDLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 274 SNNfFGEIPgWLWTLPNLFYVNLSYNTFIGFqrpnkpepsmghllgsnnnftgkipSFICELRSLETLDLSDNNFSGL-I 352
Cdd:COG4886  237 NNQ-LTDLP-ELGNLTNLEELDLSNNQLTDL-------------------------PPLANLTNLKTLDLSNNQLTDLkL 289

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 353 PRCMGNLKSNLSHLNLRQNNLSGGLPKHIFEILRSLDVGHNQLVGKLPRSLRFFSTLEVLNVESNRINDTFPFWLTSLPK 432
Cdd:COG4886  290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369


                 ..
gi 238479928 433 LQ 434
Cdd:COG4886  370 GL 371
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-466 2.28e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.05  E-value: 2.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 113 SNSSIRNLHFLTTLDLSFNDFKGQIMSSIENLSHLTYLDLSFNhfsgqvpSSIGNLSHLTFLDLYCNQFSgQVPSSIGNL 192
Cdd:COG4886   64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLT-DLPEELANL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 193 SHLTTLELSFNRFfGQFPSSIGGLSHLTTLNLFvNNFLGQIPSSIGNLSNLTSLYLCKNNFSgQIPSFIGNLSQLTRLDL 272
Cdd:COG4886  136 TNLKELDLSNNQL-TDLPEPLGNLTNLKSLDLS-NNQLTDLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDL 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 273 SSNNFfGEIPGWLWTLPNLFYVNLSyntfigfqrpnkpepsmghllgsNNNFTgKIPSfICELRSLETLDLSDNNFSGLI 352
Cdd:COG4886  213 SGNQL-TDLPEPLANLTNLETLDLS-----------------------NNQLT-DLPE-LGNLTNLEELDLSNNQLTDLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 353 PrcMGNLKsNLSHLNLRQNNLSGGLPKHIFEILRSLDVGHNQLVGKLPRSLRFFSTLEVLNVESNRINDTFPFWLTSLPK 432
Cdd:COG4886  267 P--LANLT-NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                        330       340       350
                 ....*....|....*....|....*....|....
gi 238479928 433 LQVLVLRSNAFHGPIHEASFLKLRIIDISHNHFN 466
Cdd:COG4886  344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
167-467 4.17e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 4.17e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 167 NLSHLTFLDLYCNQFSGQVPSSIGNLSHLTTLELSFNRFFGQFPSSIGGLSHLTTLNLFVNNFLGqiPSSIGNLSNLTSL 246
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG--LTDLGDLTNLTEL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 247 YLCKNNFsgqipsfIGNLSQLTRLDLSSNNFfGEIPGWLWTLPNLFYVNLSyntfigfqrpnkpepsmghllgsNNNFTg 326
Cdd:COG4886  102 DLSGNEE-------LSNLTNLESLDLSGNQL-TDLPEELANLTNLKELDLS-----------------------NNQLT- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 327 KIPSFICELRSLETLDLSDNNFSGlIPRCMGNLKsNLSHLNLRQNNLSGgLPKHIFEI--LRSLDVGHNQLvGKLPRSLR 404
Cdd:COG4886  150 DLPEPLGNLTNLKSLDLSNNQLTD-LPEELGNLT-NLKELDLSNNQITD-LPEPLGNLtnLEELDLSGNQL-TDLPEPLA 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238479928 405 FFSTLEVLNVESNRINDtFPfWLTSLPKLQVLVLRSNAFHGPIHEASFLKLRIIDISHNHFNG 467
Cdd:COG4886  226 NLTNLETLDLSNNQLTD-LP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
115-325 4.61e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 115 SSIRNLHFLTTLDLSFNDFKGqIMSSIENLSHLTYLDLSFNHFSgQVPSSIGNLSHLTFLDLYCNQFSgQVPSSIGNLSH 194
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTN 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 195 LTTLELSFNRF-----FGQFP---------------SSIGGLSHLTTLNLFVNNFLGQIPSSIGNLSNLTSLYLCKNNFS 254
Cdd:COG4886  230 LETLDLSNNQLtdlpeLGNLTnleeldlsnnqltdlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238479928 255 GQIPSFIGNLSQLTRLDLSSNNFFGEIPGWLWTLPNLFYVNLSYNTFIGFQRPNKPEPSMGHLLGSNNNFT 325
Cdd:COG4886  310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
PLN03150 PLN03150
hypothetical protein; Provisional
 122-234 1.97e-16

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 83.33  E-value: 1.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 122 FLTTLDLSFNDFKGQIMSSIENLSHLTYLDLSFNHFSGQVPSSIGNLSHLTFLDLYCNQFSGQVPSSIGNLSHLTTLELS 201
Cdd:PLN03150 419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLN 498

                         90       100       110
                 ....*....|....*....|....*....|....
gi 238479928 202 FNRFFGQFPSSIGG-LSHLTTLNLFVNNFLGQIP 234
Cdd:PLN03150 499 GNSLSGRVPAALGGrLLHRASFNFTDNAGLCGIP 532
PLN03150 PLN03150
hypothetical protein; Provisional
 207-289 2.63e-14

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 76.39  E-value: 2.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 207 GQFPSSIGGLSHLTTLNLFVNNFLGQIPSSIGNLSNLTSLYLCKNNFSGQIPSFIGNLSQLTRLDLSSNNFFGEIPGWLW 286
Cdd:PLN03150 432 GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALG 511


                 ...
gi 238479928 287 TLP 289
Cdd:PLN03150 512 GRL 514
PLN03150 PLN03150
hypothetical protein; Provisional
 150-238 6.49e-14

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 75.24  E-value: 6.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 150 LDLSFNHFSGQVPSSIGNLSHLTFLDLYCNQFSGQVPSSIGNLSHLTTLELSFNRFFGQFPSSIGGLSHLTTLNLFVNNF 229
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 ....*....
gi 238479928 230 LGQIPSSIG 238
Cdd:PLN03150 503 SGRVPAALG 511
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
239-649 9.98e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 9.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 239 NLSNLTSLYLCKNNFSGQIPSFIGNLSQLTRLDLSSNNFFGEIPGWLWTLPNLFYVNLSYNTFIGFQRPNKPEpSMGHLL 318
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT-NLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 319 GSNNNFtgkipsfICELRSLETLDLSDNNFSGLiPRCMGNLKsNLSHLNLRQNNLSGgLPKHIFEI--LRSLDVGHNQLV 396
Cdd:COG4886  103 LSGNEE-------LSNLTNLESLDLSGNQLTDL-PEELANLT-NLKELDLSNNQLTD-LPEPLGNLtnLKSLDLSNNQLT 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 397 GkLPRSLRFFSTLEVLNVESNRINDtFPFWLTSLPKLQVLVLRSNAFHG-PIHEASFLKLRIIDISHNHFNgTLPSdyfv 475
Cdd:COG4886  173 D-LPEELGNLTNLKELDLSNNQITD-LPEPLGNLTNLEELDLSGNQLTDlPEPLANLTNLETLDLSNNQLT-DLPE---- 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 476 kWSAMSSLgtdedrsnanymgsvyyqdsmvlmnkgveseliriltiyTALDFSGNKFEgEIPKSigllkellvlnlsnna 555
Cdd:COG4886  246 -LGNLTNL---------------------------------------EELDLSNNQLT-DLPPL---------------- 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 556 ftghipssmGKLTALESLDVSQNKLYGEIPQEIGNLSFLSCMNFSHNQLAGLVPGGQQFLTQPCSSFEDNLGLFGSTLEE 635
Cdd:COG4886  269 ---------ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                        410
                 ....*....|....
gi 238479928 636 DCRDIHTPASHQQY 649
Cdd:COG4886  340 LALSLSLLALLTLL 353
PLN03150 PLN03150
hypothetical protein; Provisional
 183-283 7.85e-13

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 71.77  E-value: 7.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 183 GQVPSSIGNLSHLTTLELSFNRFFGQFPSSIGGLSHLTTLNLFVNNFLGQIPSSIGNLSNLTSLYLCKNNFSGQIPSFIG 262
Cdd:PLN03150 432 GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALG 511

                         90       100
                 ....*....|....*....|..
gi 238479928 263 N-LSQLTRLDLSSNNFFGEIPG 283
Cdd:PLN03150 512 GrLLHRASFNFTDNAGLCGIPG 533
PLN03150 PLN03150
hypothetical protein; Provisional
 524-630 2.44e-12

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 70.23  E-value: 2.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 524 ALDFSGNKFEGEIPKSIGLLKELLVLNLSNNAFTGHIPSSMGKLTALESLDVSQNKLYGEIPQEIGNLSFLSCMNFSHNQ 603
Cdd:PLN03150 422 GLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501

                         90       100
                 ....*....|....*....|....*....
gi 238479928 604 LAGLVPG--GQQFLTQPCSSFEDNLGLFG 630
Cdd:PLN03150 502 LSGRVPAalGGRLLHRASFNFTDNAGLCG 530
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 39-91 2.29e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 56.15  E-value: 2.29e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 238479928   39 PEQKDALLKFKTEFeigkpcryctvycIEPHPKTESWGNNNSDCCNWEGVTCN 91
Cdd:pfam08263   2 NDDGQALLAFKSSL-------------NDPPGALSSWNSSSSDPCSWTGVTCD 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
263-612 5.71e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 5.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 263 NLSQLTRLDLSSNNFFGEIPGWLWTLPNLFYVNLSYNTFIGFQRPNKPEPSMGHLLGSNNNFTGKIPSFICELRSLETLD 342
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 343 LSDNNFsgLIPRCMGNLKsNLSHLNLRQNNLSGGLPKhifeiLRSLDVGHNQLVgKLPRSLRFFSTLEVLNVESNRINDt 422
Cdd:COG4886   81 LLSLLL--LGLTDLGDLT-NLTELDLSGNEELSNLTN-----LESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTD- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 423 FPFWLTSLPKLQVLVLRSNAFHG-PIHEASFLKLRIIDISHNHFNgTLPSDyfvkWSAMSSLgtdedrsnanymgsvyyq 501
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDlPEELGNLTNLKELDLSNNQIT-DLPEP----LGNLTNL------------------ 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 502 dsmvlmnkgveseliriltiyTALDFSGNKFEgeipksigllkellvlnlsnnaftgHIPSSMGKLTALESLDVSQNKLy 581
Cdd:COG4886  208 ---------------------EELDLSGNQLT-------------------------DLPEPLANLTNLETLDLSNNQL- 240

                        330       340       350
                 ....*....|....*....|....*....|.
gi 238479928 582 GEIPqEIGNLSFLSCMNFSHNQLAGLVPGGQ 612
Cdd:COG4886  241 TDLP-ELGNLTNLEELDLSNNQLTDLPPLAN 270
PLN03150 PLN03150
hypothetical protein; Provisional
 231-303 1.22e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.29  E-value: 1.22e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238479928 231 GQIPSSIGNLSNLTSLYLCKNNFSGQIPSFIGNLSQLTRLDLSSNNFFGEIPGWLWTLPNLFYVNLSYNTFIG 303
Cdd:PLN03150 432 GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSG 504
PLN03150 PLN03150
hypothetical protein; Provisional
 320-378 1.89e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.52  E-value: 1.89e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 238479928 320 SNNNFTGKIPSFICELRSLETLDLSDNNFSGLIPRCMGNLKSnLSHLNLRQNNLSGGLP 378
Cdd:PLN03150 450 SGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTS-LRILNLNGNSLSGRVP 507
PLN03150 PLN03150
hypothetical protein; Provisional
 255-378 2.62e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.13  E-value: 2.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 255 GQIPSFIGNLSQLTRLDLSSNNFFGEIPGWLWTLPNLFYVNLSYNTFigfqrpnkpepsmghllgsnnnfTGKIPSFICE 334
Cdd:PLN03150 432 GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF-----------------------NGSIPESLGQ 488

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 238479928 335 LRSLETLDLSDNNFSGLIPRCMGNLKSNLSHLNLRQNNLSGGLP 378
Cdd:PLN03150 489 LTSLRILNLNGNSLSGRVPAALGGRLLHRASFNFTDNAGLCGIP 532
PLN03150 PLN03150
hypothetical protein; Provisional
 321-403 2.83e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.13  E-value: 2.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 321 NNNFTGKIPSFICELRSLETLDLSDNNFSGLIPRCMGNLKSnLSHLNLRQNNLSGGLPKHIFEI--LRSLDVGHNQLVGK 398
Cdd:PLN03150 427 NQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITS-LEVLDLSYNSFNGSIPESLGQLtsLRILNLNGNSLSGR 505


                 ....*
gi 238479928 399 LPRSL 403
Cdd:PLN03150 506 VPAAL 510
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 189-371 8.05e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 189 IGNLSHLttlelSFNrffGQFPSSIGGLSH---LTTLNLFvNNFLGQIPSsIGNLSNLTSLYLcKNNFSGQIPSFiGNLS 265
Cdd:cd21340    1 LKRITHL-----YLN---DKNITKIDNLSLcknLKVLYLY-DNKITKIEN-LEFLTNLTHLYL-QNNQIEKIENL-ENLV 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 266 QLTRLDLSsNNFFGEIPGwLWTLPNLFYVNLSYntfigfQRPNKPEP------SMGHLLG-------SNNNFTgkIPSFI 332
Cdd:cd21340   69 NLKKLYLG-GNRISVVEG-LENLTNLEELHIEN------QRLPPGEKltfdprSLAALSNslrvlniSGNNID--SLEPL 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 238479928 333 CELRSLETLDLSDNNFSGL--IPRCMGNLKSnLSHLNLRQN 371
Cdd:cd21340  139 APLRNLEQLDASNNQISDLeeLLDLLSSWPS-LRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 309-463 1.10e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.28  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 309 KPEPSMGHLLGSNNnFTGKIPSF----ICELRS---LETLDLSDNNFS----GLIPRCMgnLKSNLSHLNLRQNNLS-GG 376
Cdd:cd00116   48 RPQPSLKELCLSLN-ETGRIPRGlqslLQGLTKgcgLQELDLSDNALGpdgcGVLESLL--RSSSLQELKLNNNGLGdRG 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 377 LP------KHIFEILRSLDVGHNQLVGKLPRS----LRFFSTLEVLNVESNRIND-----TFPFwLTSLPKLQVLVLRSN 441
Cdd:cd00116  125 LRllakglKDLPPALEKLVLGRNRLEGASCEAlakaLRANRDLKELNLANNGIGDagiraLAEG-LKANCNLEVLDLNNN 203

                        170       180       190
                 ....*....|....*....|....*....|.
gi 238479928 442 AFHgpiHE---------ASFLKLRIIDISHN 463
Cdd:cd00116  204 GLT---DEgasalaetlASLKSLEVLNLGDN 231
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 106-275 3.41e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 3.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 106 YLHGRFHSnsSIRNLHF---LTTLDLsfndFKGQImSSIENLS---HLTYLDLSFNHFsgqvpSSIGNLSH---LTFLDL 176
Cdd:cd21340    8 YLNDKNIT--KIDNLSLcknLKVLYL----YDNKI-TKIENLEfltNLTHLYLQNNQI-----EKIENLENlvnLKKLYL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 177 YCNQFSgqVPSSIGNLSHLTTLELSFNR-------FFGqfPSSIGGLSH-LTTLNLFVNNFlgQIPSSIGNLSNLTSLYL 248
Cdd:cd21340   76 GGNRIS--VVEGLENLTNLEELHIENQRlppgeklTFD--PRSLAALSNsLRVLNISGNNI--DSLEPLAPLRNLEQLDA 149

                        170       180
                 ....*....|....*....|....*....
gi 238479928 249 CKNNFS--GQIPSFIGNLSQLTRLDLSSN 275
Cdd:cd21340  150 SNNQISdlEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
241-299 1.42e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.42e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 238479928  241 SNLTSLYLCKNNFSGQIPSFIGNLSQLTRLDLSSNNFFGEIPGWLWTLPNLFYVNLSYN 299
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 235-419 6.42e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 6.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 235 SSIGNLS---NLTSLYLCKNNFSgQIPSFiGNLSQLTRLDLSsNNFFGEIPGwLWTLPNLFYVNLSYNtfigfqrpnkpe 311
Cdd:cd21340   15 TKIDNLSlckNLKVLYLYDNKIT-KIENL-EFLTNLTHLYLQ-NNQIEKIEN-LENLVNLKKLYLGGN------------ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 312 pSMGHLLGSNNnftgkipsficeLRSLETLDLSDNN-FSG--LI--PRCMGNLKSNLSHLNLRQNNLSGGLPKHIFEILR 386
Cdd:cd21340   79 -RISVVEGLEN------------LTNLEELHIENQRlPPGekLTfdPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLE 145

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 238479928 387 SLDVGHNQL--VGKLPRSLRFFSTLEVLNVESNRI 419
Cdd:cd21340  146 QLDASNNQIsdLEELLDLLSSWPSLRELDLTGNPV 180
PLN03150 PLN03150
hypothetical protein; Provisional
 363-452 8.98e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.04  E-value: 8.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 363 LSHLNLRQNNLSGGLPKHI--FEILRSLDVGHNQLVGKLPRSLRFFSTLEVLNVESNRINDTFPFWLTSLPKLQVLVLRS 440
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDIskLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNG 499

                         90       100
                 ....*....|....*....|.
gi 238479928 441 NAFHG---------PIHEASF 452
Cdd:PLN03150 500 NSLSGrvpaalggrLLHRASF 520
LRR_8 pfam13855
Leucine rich repeat;
145-205 3.28e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238479928  145 SHLTYLDLSFNHFSGQVPSSIGNLSHLTFLDLYCNQFSGQVPSSIGNLSHLTTLELSFNRF 205
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
407-465 3.66e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 3.66e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238479928  407 STLEVLNVESNRINDTFPFWLTSLPKLQVLVLRSNAFHGpIHEASFL---KLRIIDISHNHF 465
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSglpSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
336-395 1.10e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238479928  336 RSLETLDLSDNNFSGLIPRCMGNLkSNLSHLNLRQNNLSG-------GLPKhifeiLRSLDVGHNQL 395
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLLTTlspgafsGLPS-----LRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
217-277 2.69e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238479928  217 SHLTTLNLfVNNFLGQI-PSSIGNLSNLTSLYLCKNNFSGQIPSFIGNLSQLTRLDLSSNNF 277
Cdd:pfam13855   1 PNLRSLDL-SNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
123-176 3.03e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 3.03e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 238479928  123 LTTLDLSFNDFKGQIMSSIENLSHLTYLDLSFNHFSGQVPSSIGNLSHLTFLDL 176
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 168-421 5.49e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 5.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 168 LSHLTFLDLYCNQFSG----QVPSSIGNLSHLTTLELSFN------RFFGQFPSSIGGLSHLTTLNLFVNNFLGQIPSSI 237
Cdd:cd00116   22 LLCLQVLRLEGNTLGEeaakALASALRPQPSLKELCLSLNetgripRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 238 GNL---SNLTSLYLCKNNFSGQIPSFIG-----NLSQLTRLDLSSNNFFGE----IPGWLWTLPNLFYVNLSYNTFI--G 303
Cdd:cd00116  102 ESLlrsSSLQELKLNNNGLGDRGLRLLAkglkdLPPALEKLVLGRNRLEGAsceaLAKALRANRDLKELNLANNGIGdaG 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 304 FQRPNKPEPSMGHL--LGSNNN-FTGKIPSFICE----LRSLETLDLSDNNFSGlipRCMGNLKSNLSHLNLRqnnlsgg 376
Cdd:cd00116  182 IRALAEGLKANCNLevLDLNNNgLTDEGASALAEtlasLKSLEVLNLGDNNLTD---AGAAALASALLSPNIS------- 251

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 238479928 377 lpkhifeiLRSLDVGHNQL----VGKLPRSLRFFSTLEVLNVESNRIND 421
Cdd:cd00116  252 --------LLTLSLSCNDItddgAKDLAEVLAEKESLLELDLRGNKFGE 292
LRR_8 pfam13855
Leucine rich repeat;
361-419 6.39e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 6.39e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238479928  361 SNLSHLNLRQNNLSGgLPKHIF---EILRSLDVGHNQLVGKLPRSLRFFSTLEVLNVESNRI 419
Cdd:pfam13855   1 PNLRSLDLSNNRLTS-LDDGAFkglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
320-373 7.48e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 7.48e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 238479928  320 SNNNFTGKIPSFICELRSLETLDLSDNNFSGLIPRCMGNLKSnLSHLNLRQNNL 373
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 384-471 7.52e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 7.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 384 ILRSLDVGHNQLVGKLPRSLRFFSTLEVLNVESNRINDTFPFWLTSLPKLQVLVLRSNAFHGPIHEA--SFLKLRIIDIS 461
Cdd:PLN03150 419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESlgQLTSLRILNLN 498

                         90
                 ....*....|
gi 238479928 462 HNHFNGTLPS 471
Cdd:PLN03150 499 GNSLSGRVPA 508
LRR_8 pfam13855
Leucine rich repeat;
385-443 2.44e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 238479928  385 LRSLDVGHNQLVGKLPRSLRFFSTLEVLNVESNRINDTFPFWLTSLPKLQVLVLRSNAF 443
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 116-275 3.04e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.54  E-value: 3.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 116 SIRNLHFLTTLDLSFNDFKGQ----IMSSIENLSHLTYLDLSFNHFSGQVPSSIGNL----SHLTFLDLYCNQFSGQVPS 187
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEgaiaLAKALQGNTTLTSLDLSVNRIGDEGAIALAEGlqgnKTLHTLNLAYNGIGAQGAI 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 188 SIG----NLSHLTTLELSFNRFfgqfpSSIGGLShlttlnlfvnnfLGQipsSIGNLSNLTSLYLCKNNFSGQ-----IP 258
Cdd:COG5238  339 ALAkalqENTTLHSLDLSDNQI-----GDEGAIA------------LAK---YLEGNTTLRELNLGKNNIGKQgaealID 398

                        170
                 ....*....|....*..
gi 238479928 259 SFIGNlsQLTRLDLSSN 275
Cdd:COG5238  399 ALQTN--RLHTLILDGN 413
LRR_8 pfam13855
Leucine rich repeat;
193-248 4.07e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 238479928  193 SHLTTLELSFNRFFGQFPSSIGGLSHLTTLNLFVNNFLGQIPSSIGNLSNLTSLYL 248
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 333-421 7.34e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 7.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 333 CELRSLETLDLSDNNFS--GLIPrCMGNLKSN--LSHLNLRQNNLSG----GLPKHI--FEILRSLDVGHNQL----VGK 398
Cdd:COG5238  233 KGNKSLTTLDLSNNQIGdeGVIA-LAEALKNNttVETLYLSGNQIGAegaiALAKALqgNTTLTSLDLSVNRIgdegAIA 311

                         90       100
                 ....*....|....*....|...
gi 238479928 399 LPRSLRFFSTLEVLNVESNRIND 421
Cdd:COG5238  312 LAEGLQGNKTLHTLNLAYNGIGA 334
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 321-466 7.55e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 7.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238479928 321 NNNFTgKIPSFICeLRSLETLDLSDNNfsglIpRCMGNLKS--NLSHLNLRQNNLS-----GGLPKhifeiLRSLDVGHN 393
Cdd:cd21340   33 DNKIT-KIENLEF-LTNLTHLYLQNNQ----I-EKIENLENlvNLKKLYLGGNRISvveglENLTN-----LEELHIENQ 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238479928 394 QLVG--KL---PRSLRFFS-TLEVLNVESNRINDtfpfwLTSLPKLQvlvlrsnafhgpiheasflKLRIIDISHNHFN 466
Cdd:cd21340  101 RLPPgeKLtfdPRSLAALSnSLRVLNISGNNIDS-----LEPLAPLR-------------------NLEQLDASNNQIS 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH