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Conserved domains on  [gi|1844084133|ref|NP_001155977|]
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plasmanylethanolamine desaturase 1 isoform 2 [Homo sapiens]

Protein Classification

fatty acid desaturase family protein( domain architecture ID 10565264)

fatty acid desaturase family protein similar to human plasmanylethanolamine desaturase (transmembrane protein 189) and Arabidopsis thaliana fatty acid desaturase A that catalyzes the formation of a trans double bond introduced close to the carboxyl group of palmitic acid, in the production of chloroplast-specific phosphatidylglycerol molecular species containing 16:1(3E)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lipid_desat pfam10520
Lipid desaturase domain; This entry represents a family of lipid desaturase domains. The ...
 85-258 2.47e-95

Lipid desaturase domain; This entry represents a family of lipid desaturase domains. The TMEM189 protein is a plasmanylethanolamine desaturase enzyme. The domain is also found on fatty acid saturase FAD4 in Arabidopsis.


:

Pssm-ID: 463132  Cd Length: 174  Bit Score: 277.58  E-value: 2.47e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084133  85 LIADFLSGLVHWGADTWGSVELPI---AFIRPFREHHIDPTAITRHDFIETNGDNC-----LVTLLPLLNMaykfrthsp 156
Cdd:pfam10520   2 VLADFGSGLVHWAADTYGSVDTPVfgkAFIRAFREHHIDPTTITRHDFIETNGDNLaraatLVTIPLLLLL--------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084133 157 EALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEK 236
Cdd:pfam10520  73 NAISADYALHAFLFTFAIFVVLTNQFHKWSHTYKELPPWVRALQDAGLLLSRKHHRIHHRAPHETYYCIVTGWLNYPLDK 152

                         170       180
                  ....*....|....*....|..
gi 1844084133 237 IGFWRRLEDLIQGLTGEKPRAD 258
Cdd:pfam10520 153 IGFWRRLERVVEALTGVKPRAD 174
 
Name Accession Description Interval E-value
Lipid_desat pfam10520
Lipid desaturase domain; This entry represents a family of lipid desaturase domains. The ...
 85-258 2.47e-95

Lipid desaturase domain; This entry represents a family of lipid desaturase domains. The TMEM189 protein is a plasmanylethanolamine desaturase enzyme. The domain is also found on fatty acid saturase FAD4 in Arabidopsis.


Pssm-ID: 463132  Cd Length: 174  Bit Score: 277.58  E-value: 2.47e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084133  85 LIADFLSGLVHWGADTWGSVELPI---AFIRPFREHHIDPTAITRHDFIETNGDNC-----LVTLLPLLNMaykfrthsp 156
Cdd:pfam10520   2 VLADFGSGLVHWAADTYGSVDTPVfgkAFIRAFREHHIDPTTITRHDFIETNGDNLaraatLVTIPLLLLL--------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084133 157 EALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEK 236
Cdd:pfam10520  73 NAISADYALHAFLFTFAIFVVLTNQFHKWSHTYKELPPWVRALQDAGLLLSRKHHRIHHRAPHETYYCIVTGWLNYPLDK 152

                         170       180
                  ....*....|....*....|..
gi 1844084133 237 IGFWRRLEDLIQGLTGEKPRAD 258
Cdd:pfam10520 153 IGFWRRLERVVEALTGVKPRAD 174
 
Name Accession Description Interval E-value
Lipid_desat pfam10520
Lipid desaturase domain; This entry represents a family of lipid desaturase domains. The ...
 85-258 2.47e-95

Lipid desaturase domain; This entry represents a family of lipid desaturase domains. The TMEM189 protein is a plasmanylethanolamine desaturase enzyme. The domain is also found on fatty acid saturase FAD4 in Arabidopsis.


Pssm-ID: 463132  Cd Length: 174  Bit Score: 277.58  E-value: 2.47e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084133  85 LIADFLSGLVHWGADTWGSVELPI---AFIRPFREHHIDPTAITRHDFIETNGDNC-----LVTLLPLLNMaykfrthsp 156
Cdd:pfam10520   2 VLADFGSGLVHWAADTYGSVDTPVfgkAFIRAFREHHIDPTTITRHDFIETNGDNLaraatLVTIPLLLLL--------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084133 157 EALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEK 236
Cdd:pfam10520  73 NAISADYALHAFLFTFAIFVVLTNQFHKWSHTYKELPPWVRALQDAGLLLSRKHHRIHHRAPHETYYCIVTGWLNYPLDK 152

                         170       180
                  ....*....|....*....|..
gi 1844084133 237 IGFWRRLEDLIQGLTGEKPRAD 258
Cdd:pfam10520 153 IGFWRRLERVVEALTGVKPRAD 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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