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Conserved domains on  [gi|244790099|ref|NP_001156455|]
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leucine-rich repeat-containing protein 38 precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 20807514)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-193 7.02e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 7.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  61 DVRKLLVAGNRIQQIPEDFFIFHGdLVYLDFRNNSLRSLEEgTFSGSGKLAFLDLSYNNLTQLGAgAFRSAGRLVKLSLA 140
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLTN-LKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLS 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 244790099 141 NNHLAGVHEAaFESLESLQVLELNDNNLRSLNvAALDALPALRTVRLDGN-----PWL 193
Cdd:COG4886  191 NNQITDLPEP-LGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNqltdlPEL 246
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
190-244 1.94e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 1.94e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 244790099   190 NPWLCDCDFAHLFSWIQENTSKLPKglDAIQCSLPmEDRRVALRELSEASFSeCK 244
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDP--VDLRCASP-SSLRGPLLELLHSEFK-CP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-62 1.03e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.14  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 244790099    31 ACPAGCACTDPHtVDCRDRGLPSVPDPFPLDV 62
Cdd:smart00013   1 ACPAPCNCSGTA-VDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-193 7.02e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 7.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  61 DVRKLLVAGNRIQQIPEDFFIFHGdLVYLDFRNNSLRSLEEgTFSGSGKLAFLDLSYNNLTQLGAgAFRSAGRLVKLSLA 140
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLTN-LKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLS 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 244790099 141 NNHLAGVHEAaFESLESLQVLELNDNNLRSLNvAALDALPALRTVRLDGN-----PWL 193
Cdd:COG4886  191 NNQITDLPEP-LGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNqltdlPEL 246
LRR_8 pfam13855
Leucine rich repeat;
133-191 9.35e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 9.35e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 244790099  133 RLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSLNVAALDALPALRTVRLDGNP 191
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 49-190 1.59e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  49 RGLPSVPdpfpLDVRKLLVAGNRIQQIP----EDFFIFHGDLVYLDFRNNSL-----RSLEEGtFSGSGKLAFLDLSYNN 119
Cdd:cd00116  130 KGLKDLP----PALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIgdagiRALAEG-LKANCNLEVLDLNNNG 204

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 244790099 120 LTQLGAGAFrsagrlvklslannhlagvhEAAFESLESLQVLELNDNNLRSLNVAAL-DALPA----LRTVRLDGN 190
Cdd:cd00116  205 LTDEGASAL--------------------AETLASLKSLEVLNLGDNNLTDAGAAALaSALLSpnisLLTLSLSCN 260
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-194 1.98e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  46 CRDR-GLPSVPDPFPLDVRKLLVAGNRIQQIPEDffiFHGDLVYLDFRNNSLRSLEEgTFSGSgkLAFLDLSYNNLTQLG 124
Cdd:PRK15370 184 RLKIlGLTTIPACIPEQITTLILDNNELKSLPEN---LQGNIKTLYANSNQLTSIPA-TLPDT--IQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099 125 AgafRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLelnDNNLRS-----------LNVA--ALDALPA-----LRTVR 186
Cdd:PRK15370 258 E---RLPSALQSLDLFHNKISCLPENLPEELRYLSVY---DNSIRTlpahlpsgithLNVQsnSLTALPEtlppgLKTLE 331


                 ....*...
gi 244790099 187 LDGNPWLC 194
Cdd:PRK15370 332 AGENALTS 339
LRRCT smart00082
Leucine rich repeat C-terminal domain;
190-244 1.94e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 1.94e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 244790099   190 NPWLCDCDFAHLFSWIQENTSKLPKglDAIQCSLPmEDRRVALRELSEASFSeCK 244
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDP--VDLRCASP-SSLRGPLLELLHSEFK-CP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-62 1.03e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.14  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 244790099    31 ACPAGCACTDPHtVDCRDRGLPSVPDPFPLDV 62
Cdd:smart00013   1 ACPAPCNCSGTA-VDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 31-59 1.40e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.68  E-value: 1.40e-03
                          10        20
                  ....*....|....*....|....*....
gi 244790099   31 ACPAGCACTDPHtVDCRDRGLPSVPDPFP 59
Cdd:pfam01462   1 ACPVPCHCSATV-VNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-193 7.02e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 7.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  61 DVRKLLVAGNRIQQIPEDFFIFHGdLVYLDFRNNSLRSLEEgTFSGSGKLAFLDLSYNNLTQLGAgAFRSAGRLVKLSLA 140
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLTN-LKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLS 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 244790099 141 NNHLAGVHEAaFESLESLQVLELNDNNLRSLNvAALDALPALRTVRLDGN-----PWL 193
Cdd:COG4886  191 NNQITDLPEP-LGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNqltdlPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-201 2.56e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 2.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  43 TVDCRDRGLPSVPDPF-PLD-VRKLLVAGNRIQQIPEDFFIFHGdLVYLDFRNNSLRSLEEGtFSGSGKLAFLDLSYNNL 120
Cdd:COG4886  163 SLDLSNNQLTDLPEELgNLTnLKELDLSNNQITDLPEPLGNLTN-LEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099 121 TQLGAgaFRSAGRLVKLSLANNHLAGVHEAAfeSLESLQVLELNDNNLRSLNVAALDALPALRTVRLDGNPWLCDCDFAH 200
Cdd:COG4886  241 TDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316


                 .
gi 244790099 201 L 201
Cdd:COG4886  317 L 317
LRR_8 pfam13855
Leucine rich repeat;
133-191 9.35e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 9.35e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 244790099  133 RLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSLNVAALDALPALRTVRLDGNP 191
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
62-120 7.66e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 7.66e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 244790099   62 VRKLLVAGNRIQQIPEDFFIFHGDLVYLDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNL 120
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
113-168 1.61e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 1.61e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 244790099  113 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNL 168
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-144 1.80e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 1.80e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 244790099   86 LVYLDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHL 144
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 49-190 1.59e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  49 RGLPSVPdpfpLDVRKLLVAGNRIQQIP----EDFFIFHGDLVYLDFRNNSL-----RSLEEGtFSGSGKLAFLDLSYNN 119
Cdd:cd00116  130 KGLKDLP----PALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIgdagiRALAEG-LKANCNLEVLDLNNNG 204

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 244790099 120 LTQLGAGAFrsagrlvklslannhlagvhEAAFESLESLQVLELNDNNLRSLNVAAL-DALPA----LRTVRLDGN 190
Cdd:cd00116  205 LTDEGASAL--------------------AETLASLKSLEVLNLGDNNLTDAGAAALaSALLSpnisLLTLSLSCN 260
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-194 1.98e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  46 CRDR-GLPSVPDPFPLDVRKLLVAGNRIQQIPEDffiFHGDLVYLDFRNNSLRSLEEgTFSGSgkLAFLDLSYNNLTQLG 124
Cdd:PRK15370 184 RLKIlGLTTIPACIPEQITTLILDNNELKSLPEN---LQGNIKTLYANSNQLTSIPA-TLPDT--IQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099 125 AgafRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLelnDNNLRS-----------LNVA--ALDALPA-----LRTVR 186
Cdd:PRK15370 258 E---RLPSALQSLDLFHNKISCLPENLPEELRYLSVY---DNSIRTlpahlpsgithLNVQsnSLTALPEtlppgLKTLE 331


                 ....*...
gi 244790099 187 LDGNPWLC 194
Cdd:PRK15370 332 AGENALTS 339
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-191 1.41e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  69 GNRIQQIPEDFFIFHgdLVYLDFRNNSLRSLEEgtFSGSGKLAFLDLSYNNLT-------------------QLGAG--- 126
Cdd:cd21340   33 DNKITKIENLEFLTN--LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISvveglenltnleelhienqRLPPGekl 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 244790099 127 AF--RS----AGRLVKLSLANNHLAGVHEaaFESLESLQVLELNDNNLRSLN--VAALDALPALRTVRLDGNP 191
Cdd:cd21340  109 TFdpRSlaalSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNP 179
LRRCT smart00082
Leucine rich repeat C-terminal domain;
190-244 1.94e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 1.94e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 244790099   190 NPWLCDCDFAHLFSWIQENTSKLPKglDAIQCSLPmEDRRVALRELSEASFSeCK 244
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDP--VDLRCASP-SSLRGPLLELLHSEFK-CP 51
PLN03150 PLN03150
hypothetical protein; Provisional
 89-194 2.18e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  89 LDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNL 168
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502

                         90       100
                 ....*....|....*....|....*..
gi 244790099 169 RSLNVAALDALPALRTV-RLDGNPWLC 194
Cdd:PLN03150 503 SGRVPAALGGRLLHRASfNFTDNAGLC 529
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-190 2.76e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  92 RNNSLRSLEEgtFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSL 171
Cdd:PLN00113 461 RNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQ 538

                         90
                 ....*....|....*....
gi 244790099 172 NVAALDALPALRTVRLDGN 190
Cdd:PLN00113 539 IPASFSEMPVLSQLDLSQN 557
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-197 3.69e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 3.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  47 RDRGLPSVPDPFPLD-VRKLLVAGNRIQQ-IPEDFFIFhGDLVYLDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNLTQLG 124
Cdd:PLN00113 461 RNKFFGGLPDSFGSKrLENLDLSRNQFSGaVPRKLGSL-SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 244790099 125 AGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSlNVAALDALPALRTVRLDGNPWLCDCD 197
Cdd:PLN00113 540 PASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHG-SLPSTGAFLAINASAVAGNIDLCGGD 611
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 86-168 4.04e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 4.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  86 LVYLDFRNNSLRSLE----EGTFSGSGKLAFLDLSYNNLTQLGAGAFRSA-----GRLVKLSLANNHLAG-----VHEAA 151
Cdd:cd00116  195 LEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGAAALASAllspnISLLTLSLSCNDITDdgakdLAEVL 274

                         90
                 ....*....|....*..
gi 244790099 152 FESlESLQVLELNDNNL 168
Cdd:cd00116  275 AEK-ESLLELDLRGNKF 290
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-62 1.03e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.14  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 244790099    31 ACPAGCACTDPHtVDCRDRGLPSVPDPFPLDV 62
Cdd:smart00013   1 ACPAPCNCSGTA-VDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 31-59 1.40e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.68  E-value: 1.40e-03
                          10        20
                  ....*....|....*....|....*....
gi 244790099   31 ACPAGCACTDPHtVDCRDRGLPSVPDPFP 59
Cdd:pfam01462   1 ACPVPCHCSATV-VNCSDRGLTAVPRDLP 28
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 157-198 2.47e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 2.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 244790099  157 SLQVLELNDNNLRSLNvaALDALPALRTVRLDGNPWLCDCDF 198
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 74-168 2.60e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  74 QIPEDFFIFHGDLVYLDFRNNSLR-SLEEGTFSGsgkLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAF 152
Cdd:PLN00113 108 PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPN---LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSL 184

                         90
                 ....*....|....*.
gi 244790099 153 ESLESLQVLELNDNNL 168
Cdd:PLN00113 185 TNLTSLEFLTLASNQL 200
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-234 6.49e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 6.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099  66 LVAGNRIQQIPEDFfifhGDLV---YLDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANN 142
Cdd:PLN00113 243 LVYNNLTGPIPSSL----GNLKnlqYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099 143 HLAGVHEAAFESLESLQVLELNDNNL---------RSLNVAALDalpaLRTVRLDGNPWLCDCDFAHLFSWIQENTS--- 210
Cdd:PLN00113 319 NFTGKIPVALTSLPRLQVLQLWSNKFsgeipknlgKHNNLTVLD----LSTNNLTGEIPEGLCSSGNLFKLILFSNSleg 394

                        170       180
                 ....*....|....*....|....
gi 244790099 211 KLPKGLDAIQcSLpmedRRVALRE 234
Cdd:PLN00113 395 EIPKSLGACR-SL----RRVRLQD 413
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 94-175 7.44e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 35.98  E-value: 7.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 244790099   94 NSLRSLEEGTFSGSGKLAFLDLSyNNLTQLGAGAFRSAGrLVKLSLANNhLAGVHEAAFESLESLQVLELNdNNLRSLNV 173
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNCS-LTSITIPSS-LTSIGEYAFSNCSNLKSITLP-SNLTSIGS 95


                  ..
gi 244790099  174 AA 175
Cdd:pfam13306  96 YA 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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