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Conserved domains on  [gi|258613995|ref|NP_001158241|]
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F-box/WD repeat-containing protein 2 isoform 2 [Mus musculus]

Protein Classification

F-box/WD repeat-containing protein 2( domain architecture ID 17778610)

F-box/WD repeat-containing protein 2 functions as the substrate-recognition component of an SCF (Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.130.10.10
Gene Symbol:  FBXW2
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  31898225|11178263|30069656|29026209
SCOP:  4001927|4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-354 1.35e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.35e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 140 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 212
Cdd:cd00200    1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 213 WSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYI 292
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SPDGTF 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258613995 293 LLSA--DKYeIKIWPIGreiNCKCLKTLSVSED--RSICLQPRLhfdGKYIVCSSALGLYQWDFAS 354
Cdd:cd00200  150 VASSsqDGT-IKLWDLR---TGKCVATLTGHTGevNSVAFSPDG---EKLLSSSSDGTIKLWDLST 208
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 55-94 5.75e-20

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438903  Cd Length: 40  Bit Score: 81.99  E-value: 5.75e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 258613995  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAC 94
Cdd:cd22131    1 DFLKLLPLELSFYLLSFLDPESLLTCCLVSKQWNKVISSC 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-354 1.35e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.35e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 140 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 212
Cdd:cd00200    1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 213 WSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYI 292
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SPDGTF 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258613995 293 LLSA--DKYeIKIWPIGreiNCKCLKTLSVSED--RSICLQPRLhfdGKYIVCSSALGLYQWDFAS 354
Cdd:cd00200  150 VASSsqDGT-IKLWDLR---TGKCVATLTGHTGevNSVAFSPDG---EKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
140-359 5.38e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 5.38e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 140 ETSSLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEW 213
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFsPDGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAvtSVAFspDGKLLASGSDDGTVRLWDL 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 214 SSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYIL 293
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPDGRLL 261

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 258613995 294 LSADKY-EIKIWPIGREincKCLKTLSVSEDRSICLqpRLHFDGKYIVCSSALG-LYQWDFASYDILR 359
Cdd:COG2319  262 ASGSADgTVRLWDLATG---ELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGtVRLWDLATGKLLR 324
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 55-94 5.75e-20

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 81.99  E-value: 5.75e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 258613995  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAC 94
Cdd:cd22131    1 DFLKLLPLELSFYLLSFLDPESLLTCCLVSKQWNKVISSC 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 147-268 1.77e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 147 HSARVYALYYKDG---LLCTGSDDLSAKLWDVSTGQCVYGIQTH-TCAAVKFDE---QKLVTGSFDNTVACWEWSSGART 219
Cdd:PLN00181 574 HEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQGVSIGTIKTKaNICCVQFPSesgRSLAFGSADHKVYYYDLRNPKLP 653

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613995 220 Q-HFRGHTGAVFSVDYSDElDILVSGSADFAVKVWALSAG------TCLNTLTGHT 268
Cdd:PLN00181 654 LcTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHT 708
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 160-261 3.91e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.14  E-value: 3.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995  160 LLCTGSDDLSAKLWDVSTGQCVYGIQTH----TCAAVKFDEQKLVTGSFDNTVACWEWSSG---------ARTQHFR--- 223
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHkdvvSCVAVTSDGSILATGSYDTTVMVWEVLRGrssekrsrnTQTEFPRkdh 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 258613995  224 -----------GHTGAVFSVDYSDELDILVSGSADfavkvwalsaGTCL 261
Cdd:pfam20426 176 viaetpfhilcGHDDIITCLYVSVELDIVISGSKD----------GTCI 214
FBOX smart00256
A Receptor for Ubiquitination Targets;
60-94 5.78e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.81  E-value: 5.78e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 258613995    60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAC 94
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSH 35
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 215-253 4.02e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 258613995   215 SGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVW 253
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 60-102 4.11e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 40.54  E-value: 4.11e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 258613995   60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISaCTEVWQTAC 102
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWRELAS-DDSLWRRLC 45
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-354 1.35e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.35e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 140 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 212
Cdd:cd00200    1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 213 WSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYI 292
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SPDGTF 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258613995 293 LLSA--DKYeIKIWPIGreiNCKCLKTLSVSED--RSICLQPRLhfdGKYIVCSSALGLYQWDFAS 354
Cdd:cd00200  150 VASSsqDGT-IKLWDLR---TGKCVATLTGHTGevNSVAFSPDG---EKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
140-359 5.38e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 5.38e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 140 ETSSLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEW 213
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFsPDGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAvtSVAFspDGKLLASGSDDGTVRLWDL 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 214 SSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYIL 293
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPDGRLL 261

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 258613995 294 LSADKY-EIKIWPIGREincKCLKTLSVSEDRSICLqpRLHFDGKYIVCSSALG-LYQWDFASYDILR 359
Cdd:COG2319  262 ASGSADgTVRLWDLATG---ELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGtVRLWDLATGKLLR 324
WD40 COG2319
WD40 repeat [General function prediction only];
143-359 7.44e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 7.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 143 SLIGHSARVYALYYK--DGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSSG 216
Cdd:COG2319   73 TLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAvrSVAFspDGKTLASGSADGTVRLWDLATG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 217 ARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLS 295
Cdd:COG2319  153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF----------SPdGKLLASG 222

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 258613995 296 ADKYEIKIWPIGREincKCLKTLSVSED--RSICLQPrlhfDGKYIVCSSALG-LYQWDFASYDILR 359
Cdd:COG2319  223 SADGTVRLWDLATG---KLLRTLTGHSGsvRSVAFSP----DGRLLASGSADGtVRLWDLATGELLR 282
WD40 COG2319
WD40 repeat [General function prediction only];
143-306 1.44e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 1.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 143 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSSG 216
Cdd:COG2319  241 TLTGHSGSVRSVAFsPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGvnSVAFspDGKLLASGSDDGTVRLWDLATG 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 217 ARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLS 295
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF----------SPdGRTLASG 390

                        170
                 ....*....|.
gi 258613995 296 ADKYEIKIWPI 306
Cdd:COG2319  391 SADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-304 2.57e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 2.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 143 SLIGHSARVYALYY--KDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSSG 216
Cdd:cd00200  130 TLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEvnSVAFspDGEKLLSSSSDGTIKLWDLSTG 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 217 ARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTkvvlqkckvkSLLHSPgDYILL-- 294
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT----------SLAWSP-DGKRLas 278

                        170
                 ....*....|.
gi 258613995 295 -SADKyEIKIW 304
Cdd:cd00200  279 gSADG-TIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
143-256 1.14e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 1.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 143 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSG 216
Cdd:COG2319  283 TLTGHSGGVNSVAFsPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTgavrSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 258613995 217 ARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALS 256
Cdd:COG2319  363 ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
158-359 1.41e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 158 DGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVD 233
Cdd:COG2319   48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTaavlSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 234 YSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLSADKYEIKIWPIGreiNC 312
Cdd:COG2319  128 FSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF----------SPdGKLLASGSDDGTVRLWDLA---TG 194

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613995 313 KCLKTLSVSED--RSICLQPrlhfDGKYIVCSSALG-LYQWDFASYDILR 359
Cdd:COG2319  195 KLLRTLTGHTGavRSVAFSP----DGKLLASGSADGtVRLWDLATGKLLR 240
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 55-94 5.75e-20

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 81.99  E-value: 5.75e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 258613995  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAC 94
Cdd:cd22131    1 DFLKLLPLELSFYLLSFLDPESLLTCCLVSKQWNKVISSC 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 144-254 4.51e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 4.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 144 LIGHSARVYAL-YYKDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHT--CAAVKFDEQK--LVTGSFDNTVACWEWSSGA 217
Cdd:cd00200  173 LTGHTGEVNSVaFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHEngVNSVAFSPDGylLASGSEDGTIRVWDLRTGE 252

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 258613995 218 RTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWA 254
Cdd:cd00200  253 CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
163-359 1.37e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 163 TGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYSDEL 238
Cdd:COG2319   11 AASADLALALLAAALGALLLLLLGLAaavaSLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 239 DILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLSADKYEIKIWPIGREincKCLKT 317
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF----------SPdGKTLASGSADGTVRLWDLATG---KLLRT 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 258613995 318 LSVSED--RSICLQPrlhfDGKYIVCSSALG-LYQWDFASYDILR 359
Cdd:COG2319  158 LTGHSGavTSVAFSP----DGKLLASGSDDGtVRLWDLATGKLLR 198
WD40 COG2319
WD40 repeat [General function prediction only];
143-215 1.25e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 1.25e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 258613995 143 SLIGHSARVYAL-YYKDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSS 215
Cdd:COG2319  325 TLTGHTGAVRSVaFSPDGkTLASGSDDGTVRLWDLATGELLRTLTGHTGAvtSVAFspDGRTLASGSADGTVRLWDLAT 403
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 56-100 5.14e-07

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 45.74  E-value: 5.14e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 258613995  56 FLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAcTEVWQT 100
Cdd:cd22148    1 FISLLPEHLALKILSYLSPKELLIASQVSKTWRRLASS-NELWKA 44
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 147-268 1.77e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 147 HSARVYALYYKDG---LLCTGSDDLSAKLWDVSTGQCVYGIQTH-TCAAVKFDE---QKLVTGSFDNTVACWEWSSGART 219
Cdd:PLN00181 574 HEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQGVSIGTIKTKaNICCVQFPSesgRSLAFGSADHKVYYYDLRNPKLP 653

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613995 220 Q-HFRGHTGAVFSVDYSDElDILVSGSADFAVKVWALSAG------TCLNTLTGHT 268
Cdd:PLN00181 654 LcTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHT 708
PTZ00421 PTZ00421
coronin; Provisional
 194-272 3.05e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 3.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 194 FDEQKLVTGSFDNTVACWEWSSGARTQ-------HFRGHTGAVFSVDY-SDELDILVSGSADFAVKVWALSAGTCLNTLT 265
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGIPEEGLTQnisdpivHLQGHTKKVGIVSFhPSAMNVLASAGADMVVNVWDVERGKAVEVIK 165


                 ....*..
gi 258613995 266 GHTEWVT 272
Cdd:PTZ00421 166 CHSDQIT 172
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 56-102 3.14e-06

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 43.46  E-value: 3.14e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 258613995  56 FLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAcTEVWQTAC 102
Cdd:cd22147    1 FLSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADD-DELWKRMC 46
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 160-261 3.91e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.14  E-value: 3.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995  160 LLCTGSDDLSAKLWDVSTGQCVYGIQTH----TCAAVKFDEQKLVTGSFDNTVACWEWSSG---------ARTQHFR--- 223
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHkdvvSCVAVTSDGSILATGSYDTTVMVWEVLRGrssekrsrnTQTEFPRkdh 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 258613995  224 -----------GHTGAVFSVDYSDELDILVSGSADfavkvwalsaGTCL 261
Cdd:pfam20426 176 viaetpfhilcGHDDIITCLYVSVELDIVISGSKD----------GTCI 214
FBOX smart00256
A Receptor for Ubiquitination Targets;
60-94 5.78e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.81  E-value: 5.78e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 258613995    60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAC 94
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSH 35
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 40-87 7.75e-06

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 42.80  E-value: 7.75e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 258613995  40 QLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQW 87
Cdd:cd22133    1 QVRHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYW 48
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
 55-107 1.23e-05

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 42.27  E-value: 1.23e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613995  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWnKVISACTEVWQTACKNLGW 107
Cdd:cd22172    4 DFTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYW-KYLTELDQLWMPKCLRFGW 55
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
 55-107 2.50e-05

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 41.24  E-value: 2.50e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613995  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWnKVISACTEVWQTACKNLGW 107
Cdd:cd22173    1 DFTTVLPRFLSLYIFSFLDPRSLCRAAQVSWHW-KFLAEQDCLWMPKCVKFGW 52
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 215-253 4.02e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 258613995   215 SGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVW 253
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 60-102 4.11e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 40.54  E-value: 4.11e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 258613995   60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISaCTEVWQTAC 102
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWRELAS-DDSLWRRLC 45
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 60-92 6.00e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 39.73  E-value: 6.00e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 258613995  60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVIS 92
Cdd:cd09917    3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
WD40 pfam00400
WD domain, G-beta repeat;
216-253 1.03e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.03e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 258613995  216 GARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVW 253
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 57-102 1.71e-04

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 38.84  E-value: 1.71e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 258613995  57 LKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTAC 102
Cdd:cd22113    1 IELLPPEMSLRIFSQLDVQSLCRASQTCKTWNDLIENSDYLWRPHC 46
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 60-92 7.64e-04

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 36.67  E-value: 7.64e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 258613995  60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVIS 92
Cdd:cd22157    3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLIS 35
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 196-264 8.13e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.23  E-value: 8.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613995 196 EQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYSD-ELDILVSGSADFAVKVWALSAGTCLNTL 264
Cdd:PLN00181 545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI 614
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 57-92 1.12e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.36  E-value: 1.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 258613995   57 LKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVIS 92
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
F-box_ScCDC4-like cd22141
F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and ...
 60-103 2.08e-03

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438913  Cd Length: 47  Bit Score: 35.62  E-value: 2.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 258613995  60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAcTEVWQTACK 103
Cdd:cd22141    4 LPFEISLKIFNYLQFEDLLNSLGVSKKWNKIIRN-TALWKKLLI 46
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
 55-102 2.93e-03

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 35.50  E-value: 2.93e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 258613995  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWnKVISACTEVWQTAC 102
Cdd:cd22094    1 DFTRVLPRFLSLYIFSYLDPRSLCRAAQVSWYW-KFLCESDELWLPKC 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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