NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|270309167|ref|NP_001161857|]
View 

UDP-N-acetylglucosamine transferase subunit ALG13 isoform 4 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PssE super family cl49515
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
4-131 2.05e-33

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


The actual alignment was detected with superfamily member NF041548:

Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 113.77  E-value: 2.05e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167   4 VFVTVGTTSFDDLIACVsapDSLqkIESLGYNRLILQIGRGTVVPEPFstESFtldvyRYKDSLKEDIQKADLVISHAGA 83
Cdd:NF041548   1 IFVTVGTTRFDSLIKAI---DEL--IEGLIDYEVTFQIGDGKYIPKNG--EYF-----DFLEEIDEYYKKADLIITHAGA 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 270309167  84 GSCLETLEKGKPLVVVINEKLMNNHQLELAKQLHKEGHLFYCTCSSSL 131
Cdd:NF041548  69 GTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYDLDEL 116
 
Name Accession Description Interval E-value
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
4-131 2.05e-33

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 113.77  E-value: 2.05e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167   4 VFVTVGTTSFDDLIACVsapDSLqkIESLGYNRLILQIGRGTVVPEPFstESFtldvyRYKDSLKEDIQKADLVISHAGA 83
Cdd:NF041548   1 IFVTVGTTRFDSLIKAI---DEL--IEGLIDYEVTFQIGDGKYIPKNG--EYF-----DFLEEIDEYYKKADLIITHAGA 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 270309167  84 GSCLETLEKGKPLVVVINEKLMNNHQLELAKQLHKEGHLFYCTCSSSL 131
Cdd:NF041548  69 GTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYDLDEL 116
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 4-131 1.18e-30

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 107.41  E-value: 1.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167    4 VFVTVGTTSFDDLIACVsaPDSLQKIESLGYNRLILQIGRGTVVPEPFSTESFTL--DVYRYKDSLKEDIQKADLVISHA 81
Cdd:pfam04101   2 ILVTGGSQGARALNELV--LSVLPLLELKGELQVLHQTGKGDLEEVKIDYAELGInyEVFPFIDNMAEYIKAADLVISRA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 270309167   82 GAGSCLETLEKGKPLVVVINEK----LMNNHQLELAKQLHKEGHLFYCTCSSSL 131
Cdd:pfam04101  80 GAGTIAELLALGKPAILVPNPSaargHQDNNAKELVKAGAALVILQKELTPEKL 133
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
4-132 1.83e-22

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 86.52  E-value: 1.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167   4 VFVTVGTT--SFDDLIACVsapDSLQKIESLGYnRLILQIGRGTVVPEPFSTESFtLDvyryKDSLKEDIQKADLVISHA 81
Cdd:COG5017    2 IFVTVGTHqlPFDRLVRWV---DELAAEGIIDE-EVFVQTGHTTYVPRNAEAVPF-LP----PDEFQKLIAQARLVISHA 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 270309167  82 GAGSCLETLEKGKPLVVV-----INEKlMNNHQLELAKQLHKEGHLFYCTCSSSLR 132
Cdd:COG5017   73 GMGSILTALKLGKPFILVprlarYGEH-VDDHQLETARALEKLGGIIVVEDPADLE 127
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 22-120 4.63e-10

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 55.68  E-value: 4.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167  22 APDSLQKIESLGYNrLILQIGRG--TVVPEPFSTESFTLDVYRYKDSLKEDIQKADLVISHAGAGSCLETLEKGKPLVVV 99
Cdd:cd03785  200 VPKALPKLLERGIQ-VIHQTGKGdyDEVKKLYEDLGINVKVFPFIDDMAAAYAAADLVISRAGASTIAELTAAGKPAILI 278

                         90       100
                 ....*....|....*....|.
gi 270309167 100 INEKLMNNHQLELAKQLHKEG 120
Cdd:cd03785  279 PYPYAADDHQEANARALEKAG 299
MGT TIGR01426
glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) ...
 2-106 7.07e-04

glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance]


Pssm-ID: 273616 [Multi-domain]  Cd Length: 392  Bit Score: 38.13  E-value: 7.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167    2 KCVFVTVGT--TSFDDLI-ACVSAPDSLQKIeslgynrLILQIGRGtVVPEPFSTESFTLDVYRYKDSLkEDIQKADLVI 78
Cdd:TIGR01426 226 PVVLISLGTvfNNQPSFYrTCVEAFRDLDWH-------VVLSVGRG-VDPADLGELPPNVEVRQWVPQL-EILKKADAFI 296

                          90       100       110
                  ....*....|....*....|....*....|
gi 270309167   79 SHAGAGSCLETLEKGKPLVVV--INEKLMN 106
Cdd:TIGR01426 297 THGGMNSTMEALFNGVPMVAVpqGADQPMT 326
 
Name Accession Description Interval E-value
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
4-131 2.05e-33

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 113.77  E-value: 2.05e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167   4 VFVTVGTTSFDDLIACVsapDSLqkIESLGYNRLILQIGRGTVVPEPFstESFtldvyRYKDSLKEDIQKADLVISHAGA 83
Cdd:NF041548   1 IFVTVGTTRFDSLIKAI---DEL--IEGLIDYEVTFQIGDGKYIPKNG--EYF-----DFLEEIDEYYKKADLIITHAGA 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 270309167  84 GSCLETLEKGKPLVVVINEKLMNNHQLELAKQLHKEGHLFYCTCSSSL 131
Cdd:NF041548  69 GTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYDLDEL 116
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 4-131 1.18e-30

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 107.41  E-value: 1.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167    4 VFVTVGTTSFDDLIACVsaPDSLQKIESLGYNRLILQIGRGTVVPEPFSTESFTL--DVYRYKDSLKEDIQKADLVISHA 81
Cdd:pfam04101   2 ILVTGGSQGARALNELV--LSVLPLLELKGELQVLHQTGKGDLEEVKIDYAELGInyEVFPFIDNMAEYIKAADLVISRA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 270309167   82 GAGSCLETLEKGKPLVVVINEK----LMNNHQLELAKQLHKEGHLFYCTCSSSL 131
Cdd:pfam04101  80 GAGTIAELLALGKPAILVPNPSaargHQDNNAKELVKAGAALVILQKELTPEKL 133
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
4-132 1.83e-22

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 86.52  E-value: 1.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167   4 VFVTVGTT--SFDDLIACVsapDSLQKIESLGYnRLILQIGRGTVVPEPFSTESFtLDvyryKDSLKEDIQKADLVISHA 81
Cdd:COG5017    2 IFVTVGTHqlPFDRLVRWV---DELAAEGIIDE-EVFVQTGHTTYVPRNAEAVPF-LP----PDEFQKLIAQARLVISHA 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 270309167  82 GAGSCLETLEKGKPLVVV-----INEKlMNNHQLELAKQLHKEGHLFYCTCSSSLR 132
Cdd:COG5017   73 GMGSILTALKLGKPFILVprlarYGEH-VDDHQLETARALEKLGGIIVVEDPADLE 127
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 22-120 4.63e-10

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 55.68  E-value: 4.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167  22 APDSLQKIESLGYNrLILQIGRG--TVVPEPFSTESFTLDVYRYKDSLKEDIQKADLVISHAGAGSCLETLEKGKPLVVV 99
Cdd:cd03785  200 VPKALPKLLERGIQ-VIHQTGKGdyDEVKKLYEDLGINVKVFPFIDDMAAAYAAADLVISRAGASTIAELTAAGKPAILI 278

                         90       100
                 ....*....|....*....|.
gi 270309167 100 INEKLMNNHQLELAKQLHKEG 120
Cdd:cd03785  279 PYPYAADDHQEANARALEKAG 299
YjiC COG1819
UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];
4-111 8.55e-09

UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];


Pssm-ID: 441424 [Multi-domain]  Cd Length: 268  Bit Score: 51.78  E-value: 8.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167   4 VFVTVGTTSFDD---LIACVSApdslqkIESLGYnRLILQIGRgtVVPEPFSTESFTLDVYRYKDsLKEDIQKADLVISH 80
Cdd:COG1819  123 VYVTLGTSANDRadlLRAVLEA------LADLGV-RVVVTTGG--LDPAELGPLPDNVRVVDYVP-QDALLPRADAVVHH 192

                         90       100       110
                 ....*....|....*....|....*....|...
gi 270309167  81 AGAGSCLETLEKGKPLVVV--INEKLMNNHQLE 111
Cdd:COG1819  193 GGAGTTAEALRAGVPQVVVpfGGDQPLNAARVE 225
MurG COG0707
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope ...
 22-120 3.50e-05

UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440471 [Multi-domain]  Cd Length: 363  Bit Score: 41.65  E-value: 3.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167  22 APDSLQKIESLGYNrLILQIGRG---TVVPEPFSTESFTLDVYRYKDSLKEDIQKADLVISHAGAGSCLETLEKGKPLVV 98
Cdd:COG0707  205 VPAALAALLEARLQ-VVHQTGKGdyeEVRAAYAAAIRPNAEVFPFIDDMADAYAAADLVISRAGASTVAELAALGKPAIL 283

                         90       100
                 ....*....|....*....|..
gi 270309167  99 VINEKLMNNHQLELAKQLHKEG 120
Cdd:COG0707  284 VPLPHAADDHQTKNARALVEAG 305
MGT TIGR01426
glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) ...
 2-106 7.07e-04

glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance]


Pssm-ID: 273616 [Multi-domain]  Cd Length: 392  Bit Score: 38.13  E-value: 7.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309167    2 KCVFVTVGT--TSFDDLI-ACVSAPDSLQKIeslgynrLILQIGRGtVVPEPFSTESFTLDVYRYKDSLkEDIQKADLVI 78
Cdd:TIGR01426 226 PVVLISLGTvfNNQPSFYrTCVEAFRDLDWH-------VVLSVGRG-VDPADLGELPPNVEVRQWVPQL-EILKKADAFI 296

                          90       100       110
                  ....*....|....*....|....*....|
gi 270309167   79 SHAGAGSCLETLEKGKPLVVV--INEKLMN 106
Cdd:TIGR01426 297 THGGMNSTMEALFNGVPMVAVpqGADQPMT 326
GT1_Gtf-like cd03784
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
 73-99 2.86e-03

UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.


Pssm-ID: 340817 [Multi-domain]  Cd Length: 404  Bit Score: 36.38  E-value: 2.86e-03
                         10        20
                 ....*....|....*....|....*..
gi 270309167  73 KADLVISHAGAGSCLETLEKGKPLVVV 99
Cdd:cd03784  307 AVGAFVTHGGWNSTLEALYAGVPMVVV 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH