|
Name |
Accession |
Description |
Interval |
E-value |
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2787-2864 |
1.54e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
:
Pssm-ID: 464783 Cd Length: 78 Bit Score: 139.28 E-value: 1.54e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281360749 2787 KEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVK 2864
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL super family |
cl18310 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1137-1442 |
5.69e-35 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
The actual alignment was detected with superfamily member cd14953:
Pssm-ID: 302697 [Multi-domain] Cd Length: 323 Bit Score: 137.66 E-value: 5.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1137 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQL----------SATQVSYQYYLAVSPAdGHLYI 1204
Cdd:cd14953 14 GGGGTAARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfadgggAAAQFNTPSGVAVDAA-GNLYV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1205 SDPERHqilrlvRLEKVkDPSINSDPVVGSGQRcipgdeGNCGDGGpALLARLSHPKGLAIAADRTMYIADGTN--IRAV 1282
Cdd:cd14953 93 ADTGNH------RIRKI-TPDGVVSTLAGTGTA------GFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNhrIRKI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1283 DPKGVIHTLIGhhghhnhwSPAPCS---GTlmANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTp 1356
Cdd:cd14953 159 TPDGVVTTVAG--------TGGAGYagdGP--ATAAQFNNPTGVAVDA-AGNL-YVADRGnhrIRKITPDGVVTTVAGT- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1357 lhcsnGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTgsqtcdcaigGGS 1436
Cdd:cd14953 226 -----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR---IRKITPAGVVTTVAGGGAGF----------SGD 287
|
....*.
gi 281360749 1437 NGSATN 1442
Cdd:cd14953 288 GGPATS 293
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1881-2530 |
7.78e-30 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
:
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 130.65 E-value: 7.78e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1881 YSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFN 1960
Cdd:COG3209 375 GGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGG 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1961 RVEGWAWGPAELKYSYDRHGLLSEITSQQDGIVSFVYNDWNLVSEIGLASQRkfvlqYDDAGGLRHVVLPSGTRHSFSMQ 2040
Cdd:COG3209 455 AGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL-----GGTTTTTAGARGLVVTTGTTLTL 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2041 TSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTER 2120
Cdd:COG3209 530 GTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTT 609
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2121 ELEY-RWDFEYAAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQ 2199
Cdd:COG3209 610 TSGYtRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGT 689
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2200 PAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLV 2279
Cdd:COG3209 690 TSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLT 769
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2280 GVEAQEP-------WGFRYDDNGNLLSLTY-RGNTIPMEYNAQDRIVK-----------FGEGQYKYDARGLVAQ----- 2335
Cdd:COG3209 770 SETTPGGvtqgtytTRYTYDALGRLTSVTYpDGETVTYTYDALGRLTSvitvgsgggtdLQDRTYTYDAAGNITSitdal 849
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2336 --NAREERFHYNTQGLLVRASKRGRfDVRYYYDHLKRLTTRKDnfGNVTQFFYTNQQRPYEVSQiyspRDGKLMSLTYDD 2413
Cdd:COG3209 850 raGTLTQTYTYDALGRLTSATDPGT-TESYTYDANGNLTSRTD--GGTTTYTYDALGRLVSVTK----PDGTTTTYTYDA 922
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2414 VGHliyaqvyrhkyyvaTDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVY 2493
Cdd:COG3209 923 LGH--------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNG-ARYY 987
|
650 660 670
....*....|....*....|....*....|....*..
gi 281360749 2494 DPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2530
Cdd:COG3209 988 DPALGRFLSPD------PIGLAGGLNLYAYVGNNPVN 1018
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
723-749 |
3.40e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
:
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.06 E-value: 3.40e-09
10 20
....*....|....*....|....*..
gi 281360749 723 NCKDNIDNDGDGMTDCSDSECCSHPAC 749
Cdd:NF033662 6 TCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
558-581 |
2.67e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 43.11 E-value: 2.67e-05
10 20
....*....|....*....|....*.
gi 281360749 558 LCSGHGTCVA--GQCYCKAGWQGEDC 581
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| RHS_core super family |
cl49306 |
RHS element core protein; |
1633-1763 |
2.48e-04 |
|
RHS element core protein;
The actual alignment was detected with superfamily member NF041261:
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 46.92 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1633 SSEIYVFNRYGQHVATKDLTSGKTRYSFlysknTSFGRLSTVTDASGnkIQFLRDYSN--VVSSIENTQDHKSEIQINGI 1710
Cdd:NF041261 535 STKQMTWSRYGQLLAFTDCSGYQTRYEY-----DRFGQMTAVHREEG--ISTYRRYDNrgQLTSVKDAQGRETRYEYNAA 607
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 281360749 1711 GIMTKLSEKGRQEIELDYDSnTGLLNSRSSGGETYIYQYDEFGRVTGMILPSG 1763
Cdd:NF041261 608 GDLTAVITPDGNRSETQYDA-WGKAVSTTQGGLTRSMEYDAAGRITTLTNENG 659
|
|
| C_rich_MXAN6577 super family |
cl49352 |
MXAN_6577-like cysteine-rich domain; |
559-670 |
4.57e-04 |
|
MXAN_6577-like cysteine-rich domain;
The actual alignment was detected with superfamily member NF041328:
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 42.82 E-value: 4.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 559 CSGHGTCVAGQCYCKAGwqGEDCGtidqqvyqclpgcsehgtydletGQCVCERhwTGPD-CSQavCSLDCGRNGVCESG 637
Cdd:NF041328 49 CGAGQTCVAGACGCGPG--TVACG-----------------------GACVDTA--SDPAhCGA--CGAACAPGQVCEGG 99
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 281360749 638 KCR--CNSGWT--GNLC-----DQL---PCDSRCSEHGQCKNGTC 670
Cdd:NF041328 100 ACReaCSEGLTrcGGACvdlatDPLhcgACGVACDPGESCRGGAC 144
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
461-484 |
8.33e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 8.33e-04
10 20
....*....|....*....|....*.
gi 281360749 461 DCSGRGSCYL--GKCDCIDGYQGVDC 484
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
527-549 |
1.79e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.79e-03
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
687-716 |
3.46e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
:
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.46e-03
10 20 30
....*....|....*....|....*....|
gi 281360749 687 ENGCSRHGQCTLENGEYRCDCIEGWAGRDC 716
Cdd:cd00054 8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2787-2864 |
1.54e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 139.28 E-value: 1.54e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281360749 2787 KEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVK 2864
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1137-1442 |
5.69e-35 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 137.66 E-value: 5.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1137 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQL----------SATQVSYQYYLAVSPAdGHLYI 1204
Cdd:cd14953 14 GGGGTAARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfadgggAAAQFNTPSGVAVDAA-GNLYV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1205 SDPERHqilrlvRLEKVkDPSINSDPVVGSGQRcipgdeGNCGDGGpALLARLSHPKGLAIAADRTMYIADGTN--IRAV 1282
Cdd:cd14953 93 ADTGNH------RIRKI-TPDGVVSTLAGTGTA------GFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNhrIRKI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1283 DPKGVIHTLIGhhghhnhwSPAPCS---GTlmANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTp 1356
Cdd:cd14953 159 TPDGVVTTVAG--------TGGAGYagdGP--ATAAQFNNPTGVAVDA-AGNL-YVADRGnhrIRKITPDGVVTTVAGT- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1357 lhcsnGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTgsqtcdcaigGGS 1436
Cdd:cd14953 226 -----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR---IRKITPAGVVTTVAGGGAGF----------SGD 287
|
....*.
gi 281360749 1437 NGSATN 1442
Cdd:cd14953 288 GGPATS 293
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1881-2530 |
7.78e-30 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 130.65 E-value: 7.78e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1881 YSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFN 1960
Cdd:COG3209 375 GGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGG 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1961 RVEGWAWGPAELKYSYDRHGLLSEITSQQDGIVSFVYNDWNLVSEIGLASQRkfvlqYDDAGGLRHVVLPSGTRHSFSMQ 2040
Cdd:COG3209 455 AGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL-----GGTTTTTAGARGLVVTTGTTLTL 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2041 TSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTER 2120
Cdd:COG3209 530 GTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTT 609
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2121 ELEY-RWDFEYAAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQ 2199
Cdd:COG3209 610 TSGYtRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGT 689
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2200 PAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLV 2279
Cdd:COG3209 690 TSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLT 769
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2280 GVEAQEP-------WGFRYDDNGNLLSLTY-RGNTIPMEYNAQDRIVK-----------FGEGQYKYDARGLVAQ----- 2335
Cdd:COG3209 770 SETTPGGvtqgtytTRYTYDALGRLTSVTYpDGETVTYTYDALGRLTSvitvgsgggtdLQDRTYTYDAAGNITSitdal 849
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2336 --NAREERFHYNTQGLLVRASKRGRfDVRYYYDHLKRLTTRKDnfGNVTQFFYTNQQRPYEVSQiyspRDGKLMSLTYDD 2413
Cdd:COG3209 850 raGTLTQTYTYDALGRLTSATDPGT-TESYTYDANGNLTSRTD--GGTTTYTYDALGRLVSVTK----PDGTTTTYTYDA 922
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2414 VGHliyaqvyrhkyyvaTDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVY 2493
Cdd:COG3209 923 LGH--------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNG-ARYY 987
|
650 660 670
....*....|....*....|....*....|....*..
gi 281360749 2494 DPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2530
Cdd:COG3209 988 DPALGRFLSPD------PIGLAGGLNLYAYVGNNPVN 1018
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1965-2417 |
1.89e-14 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 80.05 E-value: 1.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1965 WAWGPA-ELKYSYDRHGllseitSQqdgIVSFVYNDWNLVSEIG--LASQRKFVLQYDDAGGLRHVVLPSGTRHSFSMQT 2041
Cdd:NF041261 322 YTYTEAgELLAVYDRSN------TQ---VRAFTYDAQHPGRMVAhrYAGRPEMCYRYDDTGRVTEQLNPAGLSYRYQYEQ 392
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2042 SigfiRCTYTPPGSTRAYLqhYSHAGALLQTILP---GDGARIVYRYNAAGQLTEVVHGDGR-SEFQYNEATGMPSTVSH 2117
Cdd:NF041261 393 D----RITITDSLNRREVL--HTEGEGGLKRVVKkehADGSVTRSGYDAAGRLTAQTDAAGRrTEYSLNVVSGDITDITT 466
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2118 TE-RELEYRWDfeyaagllaeERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGgqslPTQAFAYD-PRTGRPSLIG-- 2193
Cdd:NF041261 467 PDgRETKFYYN----------DGNQLTSVTSPDGLESRREYDEPGRLVSETSRSG----ETTRYRYDdPHSELPATTTda 532
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2194 -----QFRFSQPAQnQTQLHDGTASFTRTVDGRFQTQrmaLAIHRLEVFRMEFSYGVHGRISQTRtytrnmavNSYTNVK 2268
Cdd:NF041261 533 tgstkQMTWSRYGQ-LLAFTDCSGYQTRYEYDRFGQM---TAVHREEGISTYRRYDNRGQLTSVK--------DAQGRET 600
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2269 NYTWDCDGQLVGVEAqePWGFR----YDDNGNLLSLTYRGNTIPMEYNAQDRIVKF-----GEGQYKYDARGLVAQ---- 2335
Cdd:NF041261 601 RYEYNAAGDLTAVIT--PDGNRsetqYDAWGKAVSTTQGGLTRSMEYDAAGRITTLtnengSHSTFLYDALDRLVQqrgf 678
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2336 NAREERFHYNTQGLLVRASKRGrFDVRYYYDHLKRLTTRKDNFGNVTQFFYTNQQRPYEVSQIyspRDGKLMSL--TYDD 2413
Cdd:NF041261 679 DGRTQRYHYDLTGKLTQSEDEG-LVTLWHYDESDRITHRTVNGEPAEQWQYDEHGWLTDISHL---SEGHRVAVhyGYDD 754
|
....
gi 281360749 2414 VGHL 2417
Cdd:NF041261 755 KGRL 758
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1142-1417 |
8.71e-12 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 68.12 E-value: 8.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1142 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSATQvSYQYYLAVSPaDGHLYISDPERHQILRLvrle 1219
Cdd:COG4257 55 LGGGSGPHGIAVDPDGNLWFTDNgnNRIGRIDPKTGEITTFALPGGG-SNPHGIAFDP-DGNLWFTDQGGNRIGRL---- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1220 kvkdpsinsDPVVGSgqrcIPGDEGNCGDGGPAllarlshpkGLAIAADRTMYIAD-GTN-IRAVDPK-GVIHTLighhg 1296
Cdd:COG4257 129 ---------DPATGE----VTEFPLPTGGAGPY---------GIAVDPDGNLWVTDfGANaIGRIDPDtGTLTEY----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1297 hhnhwspapcsgtlmANQAQLQWPTGLALSPlDGSLHFIDdrlvlrltsdmkirvvagtplhcSNGGQDGRVN-KTGADN 1375
Cdd:COG4257 182 ---------------ALPTPGAGPRGLAVDP-DGNLWVAD-----------------------TGSGRIGRFDpKTGTVT 222
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 281360749 1376 VLGTVL------AMAFSPFGNLYIADSDSrrvNSIRVVDTAGNMRYFA 1417
Cdd:COG4257 223 EYPLPGggarpyGVAVDGDGRVWFAESGA---NRIVRFDPDTELTEYV 267
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1738-2375 |
1.08e-11 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 71.19 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1738 RSSGGETYIYQYDEFGRVTGMILPSGeiVRITSQLADSQgLTVyvhasVESLFSRERIAGEANellvlGGVRSTFLKRgq 1817
Cdd:NF041261 358 RYAGRPEMCYRYDDTGRVTEQLNPAG--LSYRYQYEQDR-ITI-----TDSLNRREVLHTEGE-----GGLKRVVKKE-- 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1818 aHADAELKANntlvihgdngvvvEASAVARhplLEAalpveaemlamwshQSVTMGEGLTNSMYSVYSLVGDVRNPQQTL 1897
Cdd:NF041261 423 -HADGSVTRS-------------GYDAAGR---LTA--------------QTDAAGRRTEYSLNVVSGDITDITTPDGRE 471
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1898 NREIWVNQSRVIGV----------EFDQfTNRETFYDARRTPILIVAYD--QSGLPKSYYPTNGYPVNITYDRFNRVEGW 1965
Cdd:NF041261 472 TKFYYNDGNQLTSVtspdglesrrEYDE-PGRLVSETSRSGETTRYRYDdpHSELPATTTDATGSTKQMTWSRYGQLLAF 550
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1966 A-WGPAELKYSYDRHGLLSEItSQQDGIVSF-VYNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVLPSGTRhSFSMQTSI 2043
Cdd:NF041261 551 TdCSGYQTRYEYDRFGQMTAV-HREEGISTYrRYDNRGQLTSVKDAQGRETRYEYNAAGDLTAVITPDGNR-SETQYDAW 628
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2044 GFIRCTyTPPGSTRAylQHYSHAGALLqTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGmpsTVSHTERE-L 2122
Cdd:NF041261 629 GKAVST-TQGGLTRS--MEYDAAGRIT-TLTNENGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTG---KLTQSEDEgL 701
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2123 EYRWDFEyaagllAEERIDYVAKTGLSNAKFSYE---------YDSQLRVVAL------QGRIGGQSLPTQafayDPRTG 2187
Cdd:NF041261 702 VTLWHYD------ESDRITHRTVNGEPAEQWQYDehgwltdisHLSEGHRVAVhygyddKGRLTGERQTVE----NPETG 771
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2188 RpsLIGQFR----FSQPAQNQTQLHDGTASFTRTVDGRFQTQRMALA-----------IHRlEVFRMEFSYGVHGRISQT 2252
Cdd:NF041261 772 E--LLWQHEtghaYNEQGLANRVTPDSLPPVEWLTYGSGYLAGMKLGgtplveytrdrLHR-ETVRSFGGAGSNAAYELT 848
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2253 RTYT-----RNMAVNSYTNVKNYTWDCDGQLVGVEA-QEPWGFRYDDNGNLLS-------LTYR--------GNTIP--- 2308
Cdd:NF041261 849 TAYTpagqlQSQHLNSLVYDRDYTWNDNGDLVRISGpRQTREYGYSATGRLTGvhttaanLDIRipyatdpaGNRLPdpe 928
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2309 ------MEYNAQDRIVKFGEGQYKYDARGLVAQ-------------NAREERFHYNTQGLLVRASK----RGRFDVRYYY 2365
Cdd:NF041261 929 lhpdstLTAWPDNRIAEDAHYVYRYDEYGRLTEktdripegvirtdDERTHHYHYDSQHRLVFYTRiqhgEPLVESRYLY 1008
|
730
....*....|
gi 281360749 2366 DHLKRLTTRK 2375
Cdd:NF041261 1009 DPLGRRMAKR 1018
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
723-749 |
3.40e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.06 E-value: 3.40e-09
10 20
....*....|....*....|....*..
gi 281360749 723 NCKDNIDNDGDGMTDCSDSECCSHPAC 749
Cdd:NF033662 6 TCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2454-2530 |
2.83e-08 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 52.89 E-value: 2.83e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281360749 2454 SPFGHIVYDSNPyLYLPIDFCGGILDQVTTLVHMGdGRVYDPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2530
Cdd:TIGR03696 2 DPYGEVLSESGA-APNPLRFTGQYYDAETGLYYNG-ARYYDPELGRFLSPD------PIGLGGGLNLYAYVGNNPVN 70
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
558-581 |
2.67e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 43.11 E-value: 2.67e-05
10 20
....*....|....*....|....*.
gi 281360749 558 LCSGHGTCVA--GQCYCKAGWQGEDC 581
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1633-1763 |
2.48e-04 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 46.92 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1633 SSEIYVFNRYGQHVATKDLTSGKTRYSFlysknTSFGRLSTVTDASGnkIQFLRDYSN--VVSSIENTQDHKSEIQINGI 1710
Cdd:NF041261 535 STKQMTWSRYGQLLAFTDCSGYQTRYEY-----DRFGQMTAVHREEG--ISTYRRYDNrgQLTSVKDAQGRETRYEYNAA 607
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 281360749 1711 GIMTKLSEKGRQEIELDYDSnTGLLNSRSSGGETYIYQYDEFGRVTGMILPSG 1763
Cdd:NF041261 608 GDLTAVITPDGNRSETQYDA-WGKAVSTTQGGLTRSMEYDAAGRITTLTNENG 659
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1184-1285 |
3.83e-04 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 46.38 E-value: 3.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1184 ATQVSYQYYLAV-SPADGHLYISDPERHQIlrlvrleKVKDPSINS-DPVVGSGQRCIpgdegncgDGGPALLARLSHPK 1261
Cdd:PLN02919 798 GSEVLLQHPLGVlCAKDGQIYVADSYNHKI-------KKLDPATKRvTTLAGTGKAGF--------KDGKALKAQLSEPA 862
|
90 100
....*....|....*....|....*.
gi 281360749 1262 GLAIAADRTMYIADGTN--IRAVDPK 1285
Cdd:PLN02919 863 GLALGENGRLFVADTNNslIRYLDLN 888
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
559-670 |
4.57e-04 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 42.82 E-value: 4.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 559 CSGHGTCVAGQCYCKAGwqGEDCGtidqqvyqclpgcsehgtydletGQCVCERhwTGPD-CSQavCSLDCGRNGVCESG 637
Cdd:NF041328 49 CGAGQTCVAGACGCGPG--TVACG-----------------------GACVDTA--SDPAhCGA--CGAACAPGQVCEGG 99
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 281360749 638 KCR--CNSGWT--GNLC-----DQL---PCDSRCSEHGQCKNGTC 670
Cdd:NF041328 100 ACReaCSEGLTrcGGACvdlatDPLhcgACGVACDPGESCRGGAC 144
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
641-684 |
7.46e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 39.53 E-value: 7.46e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 281360749 641 CNSGWTGNLCDQLpCDSR--------CSEHGQCkngtcVCSQGWNGRHCTLP 684
Cdd:pfam01414 1 CDENYYGSTCSKF-CRPRddkfghytCDANGNK-----VCLPGWTGPYCDKP 46
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
461-484 |
8.33e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 8.33e-04
10 20
....*....|....*....|....*.
gi 281360749 461 DCSGRGSCYL--GKCDCIDGYQGVDC 484
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
527-549 |
1.79e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.79e-03
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1728-1764 |
1.96e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 37.96 E-value: 1.96e-03
10 20 30
....*....|....*....|....*....|....*..
gi 281360749 1728 YDSNTGLLNSRSSGGETYIYQYDEFGRVTGMILPSGE 1764
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
687-716 |
3.46e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.46e-03
10 20 30
....*....|....*....|....*....|
gi 281360749 687 ENGCSRHGQCTLENGEYRCDCIEGWAGRDC 716
Cdd:cd00054 8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
655-682 |
7.60e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.46 E-value: 7.60e-03
10 20 30
....*....|....*....|....*....|....
gi 281360749 655 CDSR--CSEHGQCKNG----TCVCSQGWNGRHCT 682
Cdd:cd00054 5 CASGnpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2787-2864 |
1.54e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 139.28 E-value: 1.54e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281360749 2787 KEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVK 2864
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1137-1442 |
5.69e-35 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 137.66 E-value: 5.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1137 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQL----------SATQVSYQYYLAVSPAdGHLYI 1204
Cdd:cd14953 14 GGGGTAARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfadgggAAAQFNTPSGVAVDAA-GNLYV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1205 SDPERHqilrlvRLEKVkDPSINSDPVVGSGQRcipgdeGNCGDGGpALLARLSHPKGLAIAADRTMYIADGTN--IRAV 1282
Cdd:cd14953 93 ADTGNH------RIRKI-TPDGVVSTLAGTGTA------GFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNhrIRKI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1283 DPKGVIHTLIGhhghhnhwSPAPCS---GTlmANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTp 1356
Cdd:cd14953 159 TPDGVVTTVAG--------TGGAGYagdGP--ATAAQFNNPTGVAVDA-AGNL-YVADRGnhrIRKITPDGVVTTVAGT- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1357 lhcsnGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTgsqtcdcaigGGS 1436
Cdd:cd14953 226 -----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR---IRKITPAGVVTTVAGGGAGF----------SGD 287
|
....*.
gi 281360749 1437 NGSATN 1442
Cdd:cd14953 288 GGPATS 293
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1881-2530 |
7.78e-30 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 130.65 E-value: 7.78e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1881 YSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFN 1960
Cdd:COG3209 375 GGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGG 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1961 RVEGWAWGPAELKYSYDRHGLLSEITSQQDGIVSFVYNDWNLVSEIGLASQRkfvlqYDDAGGLRHVVLPSGTRHSFSMQ 2040
Cdd:COG3209 455 AGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL-----GGTTTTTAGARGLVVTTGTTLTL 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2041 TSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTER 2120
Cdd:COG3209 530 GTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTT 609
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2121 ELEY-RWDFEYAAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQ 2199
Cdd:COG3209 610 TSGYtRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGT 689
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2200 PAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLV 2279
Cdd:COG3209 690 TSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLT 769
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2280 GVEAQEP-------WGFRYDDNGNLLSLTY-RGNTIPMEYNAQDRIVK-----------FGEGQYKYDARGLVAQ----- 2335
Cdd:COG3209 770 SETTPGGvtqgtytTRYTYDALGRLTSVTYpDGETVTYTYDALGRLTSvitvgsgggtdLQDRTYTYDAAGNITSitdal 849
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2336 --NAREERFHYNTQGLLVRASKRGRfDVRYYYDHLKRLTTRKDnfGNVTQFFYTNQQRPYEVSQiyspRDGKLMSLTYDD 2413
Cdd:COG3209 850 raGTLTQTYTYDALGRLTSATDPGT-TESYTYDANGNLTSRTD--GGTTTYTYDALGRLVSVTK----PDGTTTTYTYDA 922
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2414 VGHliyaqvyrhkyyvaTDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVY 2493
Cdd:COG3209 923 LGH--------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNG-ARYY 987
|
650 660 670
....*....|....*....|....*....|....*..
gi 281360749 2494 DPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2530
Cdd:COG3209 988 DPALGRFLSPD------PIGLAGGLNLYAYVGNNPVN 1018
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1135-1404 |
7.13e-27 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 114.16 E-value: 7.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1135 YCNGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTIL-----------QLSATQVSYQYYLAVSPAdGH 1201
Cdd:cd14953 66 FADGGGAAAQFNTPSGVAVDAAGNLYVADTgnHRIRKITPDGVVSTLAgtgtagfsddgGATAAQFNYPTGVAVDAA-GN 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1202 LYISDPERHQILRlvrlekvkdpsINSDPVV----GSGqrcipgdEGNCGDGGPALLARLSHPKGLAIAADRTMYIADGT 1277
Cdd:cd14953 145 LYVADTGNHRIRK-----------ITPDGVVttvaGTG-------GAGYAGDGPATAAQFNNPTGVAVDAAGNLYVADRG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1278 N--IRAVDPKGVIHTLIGHHGhhnhwspAPCSGTLMANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVV 1352
Cdd:cd14953 207 NhrIRKITPDGVVTTVAGTGT-------AGFSGDGGATAAQLNNPTGVAVDA-AGNL-YVADSGnhrIRKITPAGVVTTV 277
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 281360749 1353 AGTPlhCSNGGQDGRVNKTGADNVLGtvlaMAFSPFGNLYIADSDSRRVNSI 1404
Cdd:cd14953 278 AGGG--AGFSGDGGPATSAQFNNPTG----VAVDAAGNLYVADTGNNRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1142-1401 |
4.35e-19 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 90.07 E-value: 4.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1142 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSATQVSYQYY---LAVSPaDGHLYISDPERHQILRLv 1216
Cdd:cd05819 51 DGQFNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLASFGGSGDGDGEFNGprgIAVDS-SGNIYVADTGNHRIQKF- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1217 rlekvkDPSinsdpvvGSGQRCIPGDEGNCGDggpallarLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTLIGH 1294
Cdd:cd05819 129 ------DPD-------GEFLTTFGSGGSGPGQ--------FNGPTGVAVDSDGNIYVADTGNhrIQVFDPDGNFLTTFGS 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1295 HGHHNhwspapcsgtlmanqAQLQWPTGLALSPlDGSLHFID--DRLVLRLTSDMKIRVVAGTPLhcsnggqdgrvnktG 1372
Cdd:cd05819 188 TGTGP---------------GQFNYPTGIAVDS-DGNIYVADsgNNRVQVFDPDGAGFGGNGNFL--------------G 237
|
250 260
....*....|....*....|....*....
gi 281360749 1373 ADNVLGTVLAMAFSPFGNLYIADSDSRRV 1401
Cdd:cd05819 238 SDGQFNRPSGLAVDSDGNLYVADTGNNRI 266
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1247-1442 |
1.38e-18 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 89.51 E-value: 1.38e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1247 GDGGPALLARLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTLI--GHHGHHNHWSPApcsgtlmanqAQLQWPTG 1322
Cdd:cd14953 12 FSGGGGTAARFNSPSGVAVDAAGNLYVADRGNhrIRKITPDGVVTTVAgtGTAGFADGGGAA----------AQFNTPSG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1323 LALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTplhCSNGGQDGrvnkTGADN-VLGTVLAMAFSPFGNLYIADsds 1398
Cdd:cd14953 82 VAVDA-AGNL-YVADTGnhrIRKITPDGVVSTLAGT---GTAGFSDD----GGATAaQFNYPTGVAVDAAGNLYVAD--- 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 281360749 1399 RRVNSIRVVDTAGNMRYFAgkqeGTGSQtcdcaiGGGSNGSATN 1442
Cdd:cd14953 150 TGNHRIRKITPDGVVTTVA----GTGGA------GYAGDGPATA 183
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1141-1426 |
2.43e-16 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 81.98 E-value: 2.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1141 KDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSAT---QVSYQYYLAVSPaDGHLYISDPERHQILRL 1215
Cdd:cd05819 3 GPGELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSgdgQFNEPAGVAVDS-DGNLYVADTGNHRIQKF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1216 vrlekvkdpSINSDPVVGSGqrcIPGDegncGDGGpallarLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTLIG 1293
Cdd:cd05819 82 ---------DPDGNFLASFG---GSGD----GDGE------FNGPRGIAVDSSGNIYVADTGNhrIQKFDPDGEFLTTFG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1294 HHGhhnhwspapcsgtlmANQAQLQWPTGLALSPlDGSLhFIDDRLVLRltsdmkIRVVAgtplhcSNGGQDGRVNKTGA 1373
Cdd:cd05819 140 SGG---------------SGPGQFNGPTGVAVDS-DGNI-YVADTGNHR------IQVFD------PDGNFLTTFGSTGT 190
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 281360749 1374 -DNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTGSQ 1426
Cdd:cd05819 191 gPGQFNYPTGIAVDSDGNIYVADSGNNR---VQVFDPDGAGFGGNGNFLGSDGQ 241
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1965-2417 |
1.89e-14 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 80.05 E-value: 1.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1965 WAWGPA-ELKYSYDRHGllseitSQqdgIVSFVYNDWNLVSEIG--LASQRKFVLQYDDAGGLRHVVLPSGTRHSFSMQT 2041
Cdd:NF041261 322 YTYTEAgELLAVYDRSN------TQ---VRAFTYDAQHPGRMVAhrYAGRPEMCYRYDDTGRVTEQLNPAGLSYRYQYEQ 392
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2042 SigfiRCTYTPPGSTRAYLqhYSHAGALLQTILP---GDGARIVYRYNAAGQLTEVVHGDGR-SEFQYNEATGMPSTVSH 2117
Cdd:NF041261 393 D----RITITDSLNRREVL--HTEGEGGLKRVVKkehADGSVTRSGYDAAGRLTAQTDAAGRrTEYSLNVVSGDITDITT 466
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2118 TE-RELEYRWDfeyaagllaeERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGgqslPTQAFAYD-PRTGRPSLIG-- 2193
Cdd:NF041261 467 PDgRETKFYYN----------DGNQLTSVTSPDGLESRREYDEPGRLVSETSRSG----ETTRYRYDdPHSELPATTTda 532
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2194 -----QFRFSQPAQnQTQLHDGTASFTRTVDGRFQTQrmaLAIHRLEVFRMEFSYGVHGRISQTRtytrnmavNSYTNVK 2268
Cdd:NF041261 533 tgstkQMTWSRYGQ-LLAFTDCSGYQTRYEYDRFGQM---TAVHREEGISTYRRYDNRGQLTSVK--------DAQGRET 600
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2269 NYTWDCDGQLVGVEAqePWGFR----YDDNGNLLSLTYRGNTIPMEYNAQDRIVKF-----GEGQYKYDARGLVAQ---- 2335
Cdd:NF041261 601 RYEYNAAGDLTAVIT--PDGNRsetqYDAWGKAVSTTQGGLTRSMEYDAAGRITTLtnengSHSTFLYDALDRLVQqrgf 678
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2336 NAREERFHYNTQGLLVRASKRGrFDVRYYYDHLKRLTTRKDNFGNVTQFFYTNQQRPYEVSQIyspRDGKLMSL--TYDD 2413
Cdd:NF041261 679 DGRTQRYHYDLTGKLTQSEDEG-LVTLWHYDESDRITHRTVNGEPAEQWQYDEHGWLTDISHL---SEGHRVAVhyGYDD 754
|
....
gi 281360749 2414 VGHL 2417
Cdd:NF041261 755 KGRL 758
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1141-1332 |
7.72e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 71.58 E-value: 7.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1141 KDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTIL---QLSATQVSYQYYLAVSPaDGHLYISDPERHQILRL 1215
Cdd:cd05819 97 GDGEFNGPRGIAVDSSGNIYVADTgnHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDS-DGNIYVADTGNHRIQVF 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1216 vrlekvkDPSINSDPVVGSGqrcipgdegncGDGGpallARLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTlig 1293
Cdd:cd05819 176 -------DPDGNFLTTFGST-----------GTGP----GQFNYPTGIAVDSDGNIYVADSGNnrVQVFDPDGAGFG--- 230
|
170 180 190
....*....|....*....|....*....|....*....
gi 281360749 1294 hhghhnhwspapCSGTLMANQAQLQWPTGLALSPlDGSL 1332
Cdd:cd05819 231 ------------GNGNFLGSDGQFNRPSGLAVDS-DGNL 256
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1142-1417 |
8.71e-12 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 68.12 E-value: 8.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1142 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSATQvSYQYYLAVSPaDGHLYISDPERHQILRLvrle 1219
Cdd:COG4257 55 LGGGSGPHGIAVDPDGNLWFTDNgnNRIGRIDPKTGEITTFALPGGG-SNPHGIAFDP-DGNLWFTDQGGNRIGRL---- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1220 kvkdpsinsDPVVGSgqrcIPGDEGNCGDGGPAllarlshpkGLAIAADRTMYIAD-GTN-IRAVDPK-GVIHTLighhg 1296
Cdd:COG4257 129 ---------DPATGE----VTEFPLPTGGAGPY---------GIAVDPDGNLWVTDfGANaIGRIDPDtGTLTEY----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1297 hhnhwspapcsgtlmANQAQLQWPTGLALSPlDGSLHFIDdrlvlrltsdmkirvvagtplhcSNGGQDGRVN-KTGADN 1375
Cdd:COG4257 182 ---------------ALPTPGAGPRGLAVDP-DGNLWVAD-----------------------TGSGRIGRFDpKTGTVT 222
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 281360749 1376 VLGTVL------AMAFSPFGNLYIADSDSrrvNSIRVVDTAGNMRYFA 1417
Cdd:COG4257 223 EYPLPGggarpyGVAVDGDGRVWFAESGA---NRIVRFDPDTELTEYV 267
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1738-2375 |
1.08e-11 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 71.19 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1738 RSSGGETYIYQYDEFGRVTGMILPSGeiVRITSQLADSQgLTVyvhasVESLFSRERIAGEANellvlGGVRSTFLKRgq 1817
Cdd:NF041261 358 RYAGRPEMCYRYDDTGRVTEQLNPAG--LSYRYQYEQDR-ITI-----TDSLNRREVLHTEGE-----GGLKRVVKKE-- 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1818 aHADAELKANntlvihgdngvvvEASAVARhplLEAalpveaemlamwshQSVTMGEGLTNSMYSVYSLVGDVRNPQQTL 1897
Cdd:NF041261 423 -HADGSVTRS-------------GYDAAGR---LTA--------------QTDAAGRRTEYSLNVVSGDITDITTPDGRE 471
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1898 NREIWVNQSRVIGV----------EFDQfTNRETFYDARRTPILIVAYD--QSGLPKSYYPTNGYPVNITYDRFNRVEGW 1965
Cdd:NF041261 472 TKFYYNDGNQLTSVtspdglesrrEYDE-PGRLVSETSRSGETTRYRYDdpHSELPATTTDATGSTKQMTWSRYGQLLAF 550
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1966 A-WGPAELKYSYDRHGLLSEItSQQDGIVSF-VYNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVLPSGTRhSFSMQTSI 2043
Cdd:NF041261 551 TdCSGYQTRYEYDRFGQMTAV-HREEGISTYrRYDNRGQLTSVKDAQGRETRYEYNAAGDLTAVITPDGNR-SETQYDAW 628
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2044 GFIRCTyTPPGSTRAylQHYSHAGALLqTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGmpsTVSHTERE-L 2122
Cdd:NF041261 629 GKAVST-TQGGLTRS--MEYDAAGRIT-TLTNENGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTG---KLTQSEDEgL 701
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2123 EYRWDFEyaagllAEERIDYVAKTGLSNAKFSYE---------YDSQLRVVAL------QGRIGGQSLPTQafayDPRTG 2187
Cdd:NF041261 702 VTLWHYD------ESDRITHRTVNGEPAEQWQYDehgwltdisHLSEGHRVAVhygyddKGRLTGERQTVE----NPETG 771
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2188 RpsLIGQFR----FSQPAQNQTQLHDGTASFTRTVDGRFQTQRMALA-----------IHRlEVFRMEFSYGVHGRISQT 2252
Cdd:NF041261 772 E--LLWQHEtghaYNEQGLANRVTPDSLPPVEWLTYGSGYLAGMKLGgtplveytrdrLHR-ETVRSFGGAGSNAAYELT 848
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2253 RTYT-----RNMAVNSYTNVKNYTWDCDGQLVGVEA-QEPWGFRYDDNGNLLS-------LTYR--------GNTIP--- 2308
Cdd:NF041261 849 TAYTpagqlQSQHLNSLVYDRDYTWNDNGDLVRISGpRQTREYGYSATGRLTGvhttaanLDIRipyatdpaGNRLPdpe 928
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 2309 ------MEYNAQDRIVKFGEGQYKYDARGLVAQ-------------NAREERFHYNTQGLLVRASK----RGRFDVRYYY 2365
Cdd:NF041261 929 lhpdstLTAWPDNRIAEDAHYVYRYDEYGRLTEktdripegvirtdDERTHHYHYDSQHRLVFYTRiqhgEPLVESRYLY 1008
|
730
....*....|
gi 281360749 2366 DHLKRLTTRK 2375
Cdd:NF041261 1009 DPLGRRMAKR 1018
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
723-749 |
3.40e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.06 E-value: 3.40e-09
10 20
....*....|....*....|....*..
gi 281360749 723 NCKDNIDNDGDGMTDCSDSECCSHPAC 749
Cdd:NF033662 6 TCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2454-2530 |
2.83e-08 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 52.89 E-value: 2.83e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281360749 2454 SPFGHIVYDSNPyLYLPIDFCGGILDQVTTLVHMGdGRVYDPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2530
Cdd:TIGR03696 2 DPYGEVLSESGA-APNPLRFTGQYYDAETGLYYNG-ARYYDPELGRFLSPD------PIGLGGGLNLYAYVGNNPVN 70
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1138-1296 |
5.91e-08 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 56.83 E-value: 5.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1138 GVAKDAKLLTPIALATGPDGSLYVGDFNL--VRRITPDGK-VYTI----LQLSATQVsyqyylAVSPADGHLYISDPERH 1210
Cdd:cd14962 49 GNAGPNRFVSPIGVAIDANGNLYVSDAELgkVFVFDRDGKfLRAIgagaLFKRPTGI------AVDPAGKRLYVVDTLAH 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1211 QIlrlvrleKVKDPSinsdpvvGSGQRCIpgdeGNCGDGGpallARLSHPKGLAIAADRTMYIADGTNIR--AVDPKGVI 1288
Cdd:cd14962 123 KV-------KVFDLD-------GRLLFDI----GKRGSGP----GEFNLPTDLAVDRDGNLYVTDTMNFRvqIFDADGKF 180
|
....*...
gi 281360749 1289 HTLIGHHG 1296
Cdd:cd14962 181 LRSFGERG 188
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1142-1401 |
7.57e-08 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 56.52 E-value: 7.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1142 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSAT---QVSYQYYLAVSPaDGHLYISDPERHQILRLv 1216
Cdd:cd14956 56 PGQFGRPRGLAVDKDGWLYVADYwgDRIQVFTLTGELQTIGGSSGSgpgQFNAPRGVAVDA-DGNLYVADFGNQRIQKF- 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1217 rlekvkdpsinsDP---VVGS-GQRCIPGDEGNcgdggpallarlsHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHT 1290
Cdd:cd14956 134 ------------DPdgsFLRQwGGTGIEPGSFN-------------YPRGVAVDPDGTLYVADTYNdrIQVFDNDGAFLR 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1291 LIGHHGHHNHWspapcsgtlmanqaqLQWPTGLALSPlDGSLHFID---DRlVLRLTSDMKIRVVAGTPlhcsnGGQDGR 1367
Cdd:cd14956 189 KWGGRGTGPGQ---------------FNYPYGIAIDP-DGNVFVADfgnNR-IQKFTADGTFLTSWGSP-----GTGPGQ 246
|
250 260 270
....*....|....*....|....*....|....
gi 281360749 1368 vnktgadnvLGTVLAMAFSPFGNLYIADSDSRRV 1401
Cdd:cd14956 247 ---------FKNPWGVVVDADGTVYVADSNNNRV 271
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1244-1412 |
1.73e-07 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 56.05 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1244 GNCG--DGGPALlARLSHPKGLAIAADRTMYIADGTN--IRAVDP-KGVIHTL--IGHHGHHNhwspapcSGTLMANQAQ 1316
Cdd:cd14951 4 GERGlkDGSFAE-ASFNEPQGLALLPGNILYVADTENhaLRKIDLeTGTVTTLagTGEQGRDG-------EGGGPGREQP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1317 LQwptglalSPLDGSLHFIDDRLVLR----------LTSDMKIRVVAGTplhcsngGQDGRVNKTGADNvlgTVLA---- 1382
Cdd:cd14951 76 LS-------SPWDVAWGPEDDILYIAmagthqiwayDLDTGTCRVFAGS-------GNEGNRNGPYPHE---AWFAqpsg 138
|
170 180 190
....*....|....*....|....*....|
gi 281360749 1383 MAFSPFGNLYIADSDSrrvNSIRVVDTAGN 1412
Cdd:cd14951 139 LSLAGWGELFVADSES---SAIRAVSLKDG 165
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
558-581 |
2.67e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 43.11 E-value: 2.67e-05
10 20
....*....|....*....|....*.
gi 281360749 558 LCSGHGTCVA--GQCYCKAGWQGEDC 581
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1191-1424 |
4.59e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 47.71 E-value: 4.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1191 YYLAVSPaDGHLYISDPERHQILRLvrlekvkdpsinsDPVVGSGQRcipgdegncgdggpALLARLSHPKGLAIAADRT 1270
Cdd:COG4257 20 RDVAVDP-DGAVWFTDQGGGRIGRL-------------DPATGEFTE--------------YPLGGGSGPHGIAVDPDGN 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1271 MYIADGTN--IRAVDPK-GVIHTLIGhhghhnhwsPAPCSGtlmanqaqlqwPTGLALSPlDGSLHFIDDR--LVLRLT- 1344
Cdd:COG4257 72 LWFTDNGNnrIGRIDPKtGEITTFAL---------PGGGSN-----------PHGIAFDP-DGNLWFTDQGgnRIGRLDp 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1345 SDMKIRVVAGTplhcSNGGQDGrvnktgadnvlgtvlAMAFSPFGNLYIADsdsRRVNSIRVVDTA-GNMRYFAGKQEGT 1423
Cdd:COG4257 131 ATGEVTEFPLP----TGGAGPY---------------GIAVDPDGNLWVTD---FGANAIGRIDPDtGTLTEYALPTPGA 188
|
.
gi 281360749 1424 G 1424
Cdd:COG4257 189 G 189
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1138-1220 |
6.02e-05 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 47.96 E-value: 6.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1138 GVAKDAKLLTPIALATGPDGSLYVGD-FN-LVRRITPD-GKVYTI---LQLSATQVSYQYY----LAVSPaDGHLYISDP 1207
Cdd:cd14951 188 GPGAEALLQHPLGVAALPDGSVYVADtYNhKIKRVDPAtGEVSTLagtGKAGYKDLEAQFSepsgLVVDG-DGRLYVADT 266
|
90
....*....|...
gi 281360749 1208 ERHQIlRLVRLEK 1220
Cdd:cd14951 267 NNHRI-RRLDLPT 278
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1193-1332 |
6.13e-05 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 47.96 E-value: 6.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1193 LAVSPaDGHLYISDPERhQILRLVRLEKVKDPSINSDPVVGsgqrcipgdeGNCGDGG----PALLARLSHPKGLAIAAD 1268
Cdd:cd14951 139 LSLAG-WGELFVADSES-SAIRAVSLKDGGVKTLVGGTRVG----------TGLFDFGdrdgPGAEALLQHPLGVAALPD 206
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281360749 1269 RTMYIADGTN--IRAVDPK-GVIHTLIghhghhnhwspapcsGTLMAN----QAQLQWPTGLALSPlDGSL 1332
Cdd:cd14951 207 GSVYVADTYNhkIKRVDPAtGEVSTLA---------------GTGKAGykdlEAQFSEPSGLVVDG-DGRL 261
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1633-1763 |
2.48e-04 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 46.92 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1633 SSEIYVFNRYGQHVATKDLTSGKTRYSFlysknTSFGRLSTVTDASGnkIQFLRDYSN--VVSSIENTQDHKSEIQINGI 1710
Cdd:NF041261 535 STKQMTWSRYGQLLAFTDCSGYQTRYEY-----DRFGQMTAVHREEG--ISTYRRYDNrgQLTSVKDAQGRETRYEYNAA 607
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 281360749 1711 GIMTKLSEKGRQEIELDYDSnTGLLNSRSSGGETYIYQYDEFGRVTGMILPSG 1763
Cdd:NF041261 608 GDLTAVITPDGNRSETQYDA-WGKAVSTTQGGLTRSMEYDAAGRITTLTNENG 659
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1198-1424 |
3.35e-04 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 45.27 E-value: 3.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1198 ADGHLYISDPERHQILRLvrlekvkDPSinsdpvvGSGQRCIPGDEGncgdggpallarlsHPKGLAIAADRTMYIAD-G 1276
Cdd:COG3386 17 PDGRLYWVDIPGGRIHRY-------DPD-------GGAVEVFAEPSG--------------RPNGLAFDPDGRLLVADhG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1277 TNIRAVDPK-GVIHTLIGHHGHhnhwspapcsgtlmanqaQLQWPTGLALSPlDGSL------HFIDDRLVLRLTSDMKI 1349
Cdd:COG3386 69 RGLVRFDPAdGEVTVLADEYGK------------------PLNRPNDGVVDP-DGRLyftdmgEYLPTGALYRVDPDGSL 129
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281360749 1350 RVVAgTPLHCSNGgqdgrvnktgadnvlgtvlaMAFSPFGN-LYIADSDSRRVNSIRVVD--TAGNMRYFAGKQEGTG 1424
Cdd:COG3386 130 RVLA-DGLTFPNG--------------------IAFSPDGRtLYVADTGAGRIYRFDLDAdgTLGNRRVFADLPDGPG 186
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1184-1285 |
3.83e-04 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 46.38 E-value: 3.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1184 ATQVSYQYYLAV-SPADGHLYISDPERHQIlrlvrleKVKDPSINS-DPVVGSGQRCIpgdegncgDGGPALLARLSHPK 1261
Cdd:PLN02919 798 GSEVLLQHPLGVlCAKDGQIYVADSYNHKI-------KKLDPATKRvTTLAGTGKAGF--------KDGKALKAQLSEPA 862
|
90 100
....*....|....*....|....*.
gi 281360749 1262 GLAIAADRTMYIADGTN--IRAVDPK 1285
Cdd:PLN02919 863 GLALGENGRLFVADTNNslIRYLDLN 888
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1151-1292 |
4.54e-04 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.88 E-value: 4.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1151 LATGPDGSLYVGDFNLVR------RITPDGKVYTIlqlsATQVSYQYYLAVSPADGHLYISDPERHQILRLvrlekvkdp 1224
Cdd:COG3386 98 GVVDPDGRLYFTDMGEYLptgalyRVDPDGSLRVL----ADGLTFPNGIAFSPDGRTLYVADTGAGRIYRF--------- 164
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1225 SINSDPVVGSGQRCIPGDEgncGDGGPAllarlshpkGLAIAADRTMYIA--DGTNIRAVDPKGVIHTLI 1292
Cdd:COG3386 165 DLDADGTLGNRRVFADLPD---GPGGPD---------GLAVDADGNLWVAlwGGGGVVRFDPDGELLGRI 222
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
559-670 |
4.57e-04 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 42.82 E-value: 4.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 559 CSGHGTCVAGQCYCKAGwqGEDCGtidqqvyqclpgcsehgtydletGQCVCERhwTGPD-CSQavCSLDCGRNGVCESG 637
Cdd:NF041328 49 CGAGQTCVAGACGCGPG--TVACG-----------------------GACVDTA--SDPAhCGA--CGAACAPGQVCEGG 99
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 281360749 638 KCR--CNSGWT--GNLC-----DQL---PCDSRCSEHGQCKNGTC 670
Cdd:NF041328 100 ACReaCSEGLTrcGGACvdlatDPLhcgACGVACDPGESCRGGAC 144
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1137-1215 |
4.83e-04 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 44.62 E-value: 4.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1137 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTIL---QLSATQVSYQYYLAVSPaDGHLYISDPERHQ 1211
Cdd:cd05819 187 STGTGPGQFNYPTGIAVDSDGNIYVADSgnNRVQVFDPDGAGFGGNgnfLGSDGQFNRPSGLAVDS-DGNLYVADTGNNR 265
|
....
gi 281360749 1212 ILRL 1215
Cdd:cd05819 266 IQVF 269
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
641-684 |
7.46e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 39.53 E-value: 7.46e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 281360749 641 CNSGWTGNLCDQLpCDSR--------CSEHGQCkngtcVCSQGWNGRHCTLP 684
Cdd:pfam01414 1 CDENYYGSTCSKF-CRPRddkfghytCDANGNK-----VCLPGWTGPYCDKP 46
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
461-484 |
8.33e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 8.33e-04
10 20
....*....|....*....|....*.
gi 281360749 461 DCSGRGSCYL--GKCDCIDGYQGVDC 484
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| YliI |
COG2133 |
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism]; |
1148-1279 |
1.03e-03 |
|
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];
Pssm-ID: 441736 [Multi-domain] Cd Length: 365 Bit Score: 44.15 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1148 PIALATGPDGSLYVGD-FNLVRRITPDGKVYTILQLSATQVSYQY---YLAVSP---ADGHLYI--SDPERHQiLRLVRL 1218
Cdd:COG2133 39 PWGLAFLPDGRLLVTErAGRIRLLDDDGKLSTPVADLPVFAGGEGgllGVALDPdfaTNGYLYVayTDPGGAG-TRVARF 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281360749 1219 EKVKDPSINSDPVVGSGqrcIPGDEGNcgdggpallarlsHP-KGLAIAADRTMYIA--DGTNI 1279
Cdd:COG2133 118 TLSDGDTLTSEEVILDG---LPAGGGN-------------HNgGRLAFGPDGKLYVSvgDRGNA 165
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
595-619 |
1.07e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.07e-03
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
527-549 |
1.79e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.79e-03
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1728-1764 |
1.96e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 37.96 E-value: 1.96e-03
10 20 30
....*....|....*....|....*....|....*..
gi 281360749 1728 YDSNTGLLNSRSSGGETYIYQYDEFGRVTGMILPSGE 1764
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
627-650 |
2.58e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.33 E-value: 2.58e-03
10 20
....*....|....*....|....*.
gi 281360749 627 DCGRNGVCES--GKCRCNSGWTGNLC 650
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
659-681 |
2.60e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.33 E-value: 2.60e-03
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
687-716 |
3.46e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.46e-03
10 20 30
....*....|....*....|....*....|
gi 281360749 687 ENGCSRHGQCTLENGEYRCDCIEGWAGRDC 716
Cdd:cd00054 8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
458-485 |
4.56e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 36.89 E-value: 4.56e-03
10 20
....*....|....*....|....*...
gi 281360749 458 CPNDCSGRGSCYLGKCDCIDGYQGVDCS 485
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1151-1285 |
5.85e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 41.79 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1151 LATGPDGSLYVGD--FNLVRRITP-DGKVYTILQLS---------------ATQVSYQYYLAVSPA-DGHLYISDPERHQ 1211
Cdd:cd14951 139 LSLAGWGELFVADseSSAIRAVSLkDGGVKTLVGGTrvgtglfdfgdrdgpGAEALLQHPLGVAALpDGSVYVADTYNHK 218
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281360749 1212 ILRLvrlekvkdpsinsDPVVGSGQRCIPGDEGNCGDggpaLLARLSHPKGLAIAADRTMYIADgTN---IRAVDPK 1285
Cdd:cd14951 219 IKRV-------------DPATGEVSTLAGTGKAGYKD----LEAQFSEPSGLVVDGDGRLYVAD-TNnhrIRRLDLP 277
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
506-551 |
6.01e-03 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 36.83 E-value: 6.01e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 281360749 506 CEEGWKGAECDIpvgECEVPN-------CSSHGRCIegechCERGWKGPYCDQ 551
Cdd:pfam01414 1 CDENYYGSTCSK---FCRPRDdkfghytCDANGNKV-----CLPGWTGPYCDK 45
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1155-1434 |
7.07e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 41.03 E-value: 7.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1155 PDGSLYVGDF--NLVRRITPDGKVYTILQLSATQVSYqyyLAVSPaDGHLYISDPERhqilRLVRLEKvkdpsinsdpvv 1232
Cdd:COG3386 17 PDGRLYWVDIpgGRIHRYDPDGGAVEVFAEPSGRPNG---LAFDP-DGRLLVADHGR----GLVRFDP------------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1233 gsgqrcipgdegncGDGGPALLA-----RLSHPKGLAIAADRTMYIAD------GTNIRAVDPKGVIHTLIGHhghhnhw 1301
Cdd:COG3386 77 --------------ADGEVTVLAdeygkPLNRPNDGVVDPDGRLYFTDmgeylpTGALYRVDPDGSLRVLADG------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360749 1302 spapcsgtlmanqaqLQWPTGLALSPlDGS-LHFID--DRLVLRLTSDMKIRVVAGTPLHcsnggqDGRVNKTGADNvlg 1378
Cdd:COG3386 136 ---------------LTFPNGIAFSP-DGRtLYVADtgAGRIYRFDLDADGTLGNRRVFA------DLPDGPGGPDG--- 190
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 281360749 1379 tvlaMAFSPFGNLYIADSDSRRVnsiRVVDTAGNMRyfaGKQEGTGSQTCDCAIGG 1434
Cdd:COG3386 191 ----LAVDADGNLWVALWGGGGV---VRFDPDGELL---GRIELPERRPTNVAFGG 236
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
655-682 |
7.60e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.46 E-value: 7.60e-03
10 20 30
....*....|....*....|....*....|....
gi 281360749 655 CDSR--CSEHGQCKNG----TCVCSQGWNGRHCT 682
Cdd:cd00054 5 CASGnpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| EGF |
cd00053 |
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
688-716 |
7.65e-03 |
|
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.
Pssm-ID: 238010 Cd Length: 36 Bit Score: 36.30 E-value: 7.65e-03
10 20 30
....*....|....*....|....*....|
gi 281360749 688 NGCSRHGQCTLENGEYRCDCIEGWAG-RDC 716
Cdd:cd00053 6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSC 35
|
|
| |
