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Conserved domains on  [gi|281360162|ref|NP_001163053|]
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Nipped-B, isoform H [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCC2 cd23958
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
 536-1877 0e+00

Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.


:

Pssm-ID: 467937 [Multi-domain]  Cd Length: 1197  Bit Score: 1079.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  536 KLTLLINYAMRNVYLARNYFAGTEDEDEFV-----DDEVIEKLLNAMDACLLIcnIYSTVSDLQFLQEDNVSHIIKFTQF 610
Cdd:cd23958     1 KLVRLLTILERNIRDGESLDLDLDESQEDDeerlwLLERIDRALEAADASLTI--LTSPGLPKQLYSEDLIERVVDFLKF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  611 QLRETIFPLHDPVYTAKSIKRTTHRKKIKSHQAQNRSMQLFYLKTVELLKVFVTLFDKCVFVDTIVLPLSTLAIEPFFVD 690
Cdd:cd23958    79 QLENTIYPAYDPVYRSDSSAKAGKKKRAKASSKKKKSVSTLLNKLCELLSLLAELLSLQSLTDSVILQLVYLAISPFFVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  691 ----NIETLQFVCLELVTTIFRkeRYDKIRNSILGDILTSIDRLPSSKKNLRPYKLtNNGGNIQMVTALVLQLIQCATIL 766
Cdd:cd23958   159 navsNVDELQLSALKLLTSIFS--RYPDQRQFIIEEILSSLAKLPSSKRNLRQFRL-NDGKSIQMVTALLLQLVQSSVKL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  767 PDSLCDNGKFSNKPQEGNTFDEEgkkllqpsQDLLVLQKYDVAVSIGGNFLTTFLNKC--KSRSNETDFRPLFENFIHDL 844
Cdd:cd23958   236 PNLEKESSRDKSLEEDSDELLED--------EESALAKSYESAVRIASYFLSFLLQKCtkKKKEKDTDYRPLFENFVQDL 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  845 LATVNKPEWPASELLLSLLGTMLVRYVSDKGIEQSIRLVSLDYLGIVAARLRKDTVEsrcrvniidsmiqsikleqekeg 924
Cdd:cd23958   308 LTVLNLPEWPAAELLLSLLGRLLVSIFSNKKTDANARVMALDLLGLIAARLRKDALA----------------------- 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  925 dvtsnndqfdlepeeqrtDFLQKILLDFLAVNAQEENLIWdYARHFYLAQWYRDVIYQRRRINDgkkglafrkskirnnr 1004
Cdd:cd23958   365 ------------------EELQKALLDYLAENSSSDPSLE-SARGFYLAQWLRDLSNELEKAEK---------------- 409

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1005 rtngdyldtsdsgscdesdtdTNKKRIHCVDSNDFELNINIYKALEARKQYfinkikpfsvfgeqnhssnqhIKTYIDYN 1084
Cdd:cd23958   410 ---------------------AAEEEDTILKLELSELRKKFLDSKILSKEE---------------------EASPLSRE 447

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1085 NAQLIAQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRAMKCLANIVEVDPLVLKRKDMQMGVNQKFLDTAISVREAA 1164
Cdd:cd23958   448 DAKLLYRALASQRPLSQSFDPILKQLLSSLDEPAVTLRTKALKALSLVVEADPSILGDPDVQRAVEGRLLDSSASVREAA 527

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1165 VDLVGKFVLSNQDLIDQYYDMLSTRILDTGVSVRKRVIKILRDICLEYPDFSKIPEICVKMIRRVHD-EEGIQKLVTEVF 1243
Cdd:cd23958   528 VELVGKYISSRPDLAEQYYEMIAERILDTGVSVRKRVIKILRDIYLRTPDFEIKVDICVRLLRRINDeEESIKDLARKTF 607

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1244 MKMWFTPCTKN-----DKIGIQRKINHIIDVVNtAHDTGTTWLEGLLMSIFKPrdnmlrsegcvqefikKNSEPPMDIVI 1318
Cdd:cd23958   608 QELWFTPFPESsspaqDKESLAERVLLIVDVVA-ACRKGLDLLEQLLKRLLKS----------------KEDKEDKSVRK 670

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1319 ACQQLADGLVDRLIELE----DTDNSRMLGCITTLHLLAKVRP-QLLVKHAITIEPYLNIKCHSATAAKFICAVADILEK 1393
Cdd:cd23958   671 ACKQLVDCLVELILELEedddESSESDLVACLSTLHLFAKADPkLLLVEHAETLQPYLKSKCSTREDQQVLRYVLRILRS 750

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1394 VVPLVNNASESFLASLEEHLMLLVVSRNQAEVTSCVSCLGALVNKITHNFKLIRDCFQKFYRVLDVSRSQVIQGNNSVDN 1473
Cdd:cd23958   751 VLPLLSHPSESFLEELEEDLLKLLLKHSVTVLQEAIACLCAVVNKLTKNYERLRKALQSCLKLLRKYKRQANLDPSSLKE 830

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1474 IytPSFRRSLFTIGILMRYFDFKSPIALGETNDGL-PVSICEDVFHCLMFFCRC-TNQEIRKQALISLGSFCVLNDGYLT 1551
Cdd:cd23958   831 D--PKLLRLLYILGLLARYCDFDSERDDFEKAPLKtKESVKELVFDLLLFFTKPpIDEDVRKKALQALGFLCIAHPKLFL 908

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1552 RSELKNLYCEILSSiaNDAGFKIICMRNIWIYLTESEMFMHNKEKEWEKQSK-----HEDLKEMNDVSSGMASRIIQLYL 1626
Cdd:cd23958   909 SPEVLKLLDEILAS--GSLKLKLQVLRNLQEFLQAEEKRMEAADAEWKKNSKaadvkVLDGKEMGDADSGVASSIMQRYL 986

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1627 EEILECFLNRDDTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVNMKVQFGLQL 1706
Cdd:cd23958   987 KDILELCLSSDSQVRLAALKVLELILRQGLVHPIQCVPTLIALETDPNPAIRKLALRLLKELHEKYESLVESKYLEGVRL 1066

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1707 CFKLQKILQINNRGKLeiirgyasRGPDNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFDDQ-------KTSLQQMLYI 1779
Cdd:cd23958  1067 AFQYQKRLAGDTRGRG--------FRTDSPPTALLGRLYSLLRGNRKSRRKFLKSLLKLFDFDlkkssdsPSDLDFLLFL 1138

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1780 ADNLAYFPYVVQDEPLYLIHQIDLLISMAGTHLLATFkehikpsdkegdvleddddvedpevlfnrlpedlteiikcITS 1859
Cdd:cd23958  1139 AENLAFLPYQTQDEPLFVIHTIDRILSVTGSSLLQAI----------------------------------------AKA 1178

                        1370
                  ....*....|....*...
gi 281360162 1860 AQACMLLLILKDHLKEMY 1877
Cdd:cd23958  1179 SQALLLLLLLKQHLKRLY 1196
 
Name Accession Description Interval E-value
SCC2 cd23958
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
 536-1877 0e+00

Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.


Pssm-ID: 467937 [Multi-domain]  Cd Length: 1197  Bit Score: 1079.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  536 KLTLLINYAMRNVYLARNYFAGTEDEDEFV-----DDEVIEKLLNAMDACLLIcnIYSTVSDLQFLQEDNVSHIIKFTQF 610
Cdd:cd23958     1 KLVRLLTILERNIRDGESLDLDLDESQEDDeerlwLLERIDRALEAADASLTI--LTSPGLPKQLYSEDLIERVVDFLKF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  611 QLRETIFPLHDPVYTAKSIKRTTHRKKIKSHQAQNRSMQLFYLKTVELLKVFVTLFDKCVFVDTIVLPLSTLAIEPFFVD 690
Cdd:cd23958    79 QLENTIYPAYDPVYRSDSSAKAGKKKRAKASSKKKKSVSTLLNKLCELLSLLAELLSLQSLTDSVILQLVYLAISPFFVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  691 ----NIETLQFVCLELVTTIFRkeRYDKIRNSILGDILTSIDRLPSSKKNLRPYKLtNNGGNIQMVTALVLQLIQCATIL 766
Cdd:cd23958   159 navsNVDELQLSALKLLTSIFS--RYPDQRQFIIEEILSSLAKLPSSKRNLRQFRL-NDGKSIQMVTALLLQLVQSSVKL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  767 PDSLCDNGKFSNKPQEGNTFDEEgkkllqpsQDLLVLQKYDVAVSIGGNFLTTFLNKC--KSRSNETDFRPLFENFIHDL 844
Cdd:cd23958   236 PNLEKESSRDKSLEEDSDELLED--------EESALAKSYESAVRIASYFLSFLLQKCtkKKKEKDTDYRPLFENFVQDL 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  845 LATVNKPEWPASELLLSLLGTMLVRYVSDKGIEQSIRLVSLDYLGIVAARLRKDTVEsrcrvniidsmiqsikleqekeg 924
Cdd:cd23958   308 LTVLNLPEWPAAELLLSLLGRLLVSIFSNKKTDANARVMALDLLGLIAARLRKDALA----------------------- 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  925 dvtsnndqfdlepeeqrtDFLQKILLDFLAVNAQEENLIWdYARHFYLAQWYRDVIYQRRRINDgkkglafrkskirnnr 1004
Cdd:cd23958   365 ------------------EELQKALLDYLAENSSSDPSLE-SARGFYLAQWLRDLSNELEKAEK---------------- 409

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1005 rtngdyldtsdsgscdesdtdTNKKRIHCVDSNDFELNINIYKALEARKQYfinkikpfsvfgeqnhssnqhIKTYIDYN 1084
Cdd:cd23958   410 ---------------------AAEEEDTILKLELSELRKKFLDSKILSKEE---------------------EASPLSRE 447

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1085 NAQLIAQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRAMKCLANIVEVDPLVLKRKDMQMGVNQKFLDTAISVREAA 1164
Cdd:cd23958   448 DAKLLYRALASQRPLSQSFDPILKQLLSSLDEPAVTLRTKALKALSLVVEADPSILGDPDVQRAVEGRLLDSSASVREAA 527

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1165 VDLVGKFVLSNQDLIDQYYDMLSTRILDTGVSVRKRVIKILRDICLEYPDFSKIPEICVKMIRRVHD-EEGIQKLVTEVF 1243
Cdd:cd23958   528 VELVGKYISSRPDLAEQYYEMIAERILDTGVSVRKRVIKILRDIYLRTPDFEIKVDICVRLLRRINDeEESIKDLARKTF 607

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1244 MKMWFTPCTKN-----DKIGIQRKINHIIDVVNtAHDTGTTWLEGLLMSIFKPrdnmlrsegcvqefikKNSEPPMDIVI 1318
Cdd:cd23958   608 QELWFTPFPESsspaqDKESLAERVLLIVDVVA-ACRKGLDLLEQLLKRLLKS----------------KEDKEDKSVRK 670

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1319 ACQQLADGLVDRLIELE----DTDNSRMLGCITTLHLLAKVRP-QLLVKHAITIEPYLNIKCHSATAAKFICAVADILEK 1393
Cdd:cd23958   671 ACKQLVDCLVELILELEedddESSESDLVACLSTLHLFAKADPkLLLVEHAETLQPYLKSKCSTREDQQVLRYVLRILRS 750

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1394 VVPLVNNASESFLASLEEHLMLLVVSRNQAEVTSCVSCLGALVNKITHNFKLIRDCFQKFYRVLDVSRSQVIQGNNSVDN 1473
Cdd:cd23958   751 VLPLLSHPSESFLEELEEDLLKLLLKHSVTVLQEAIACLCAVVNKLTKNYERLRKALQSCLKLLRKYKRQANLDPSSLKE 830

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1474 IytPSFRRSLFTIGILMRYFDFKSPIALGETNDGL-PVSICEDVFHCLMFFCRC-TNQEIRKQALISLGSFCVLNDGYLT 1551
Cdd:cd23958   831 D--PKLLRLLYILGLLARYCDFDSERDDFEKAPLKtKESVKELVFDLLLFFTKPpIDEDVRKKALQALGFLCIAHPKLFL 908

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1552 RSELKNLYCEILSSiaNDAGFKIICMRNIWIYLTESEMFMHNKEKEWEKQSK-----HEDLKEMNDVSSGMASRIIQLYL 1626
Cdd:cd23958   909 SPEVLKLLDEILAS--GSLKLKLQVLRNLQEFLQAEEKRMEAADAEWKKNSKaadvkVLDGKEMGDADSGVASSIMQRYL 986

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1627 EEILECFLNRDDTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVNMKVQFGLQL 1706
Cdd:cd23958   987 KDILELCLSSDSQVRLAALKVLELILRQGLVHPIQCVPTLIALETDPNPAIRKLALRLLKELHEKYESLVESKYLEGVRL 1066

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1707 CFKLQKILQINNRGKLeiirgyasRGPDNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFDDQ-------KTSLQQMLYI 1779
Cdd:cd23958  1067 AFQYQKRLAGDTRGRG--------FRTDSPPTALLGRLYSLLRGNRKSRRKFLKSLLKLFDFDlkkssdsPSDLDFLLFL 1138

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1780 ADNLAYFPYVVQDEPLYLIHQIDLLISMAGTHLLATFkehikpsdkegdvleddddvedpevlfnrlpedlteiikcITS 1859
Cdd:cd23958  1139 AENLAFLPYQTQDEPLFVIHTIDRILSVTGSSLLQAI----------------------------------------AKA 1178

                        1370
                  ....*....|....*...
gi 281360162 1860 AQACMLLLILKDHLKEMY 1877
Cdd:cd23958  1179 SQALLLLLLLKQHLKRLY 1196
Nipped-B_C pfam12830
Sister chromatid cohesion C-terminus; This domain lies towards the C-terminus of nipped-B or ...
 1618-1802 3.25e-53

Sister chromatid cohesion C-terminus; This domain lies towards the C-terminus of nipped-B or sister chromatid cohesion proteins.


Pssm-ID: 463722  Cd Length: 180  Bit Score: 184.66  E-value: 3.25e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  1618 ASRIIQLYLEEILECFLNRDDTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVN 1697
Cdd:pfam12830    1 CSALVQRYLKHILEICLSSDDQVRLLALEVLALILRQGLVHPKECIPTLIALETSPNPYIRKLAFELHKELHEKHESLLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  1698 MKVQFGLQLCFKLQKILQINNRGkleiirgyasrgpdNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFDD-------QK 1770
Cdd:pfam12830   81 SRYMEGIRLAFEYQRRVLSGATL--------------EPPTSFLSLLYSLLRSNKKSRKKFLKSLVKLFFDldlssesSP 146

                          170       180       190
                   ....*....|....*....|....*....|..
gi 281360162  1771 TSLQQMLYIADNLAYFPYVVQDEPLYLIHQID 1802
Cdd:pfam12830  147 SDLDFLRFLAENLAFLPYQTQDEVLFLIHHID 178
 
Name Accession Description Interval E-value
SCC2 cd23958
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
 536-1877 0e+00

Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.


Pssm-ID: 467937 [Multi-domain]  Cd Length: 1197  Bit Score: 1079.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  536 KLTLLINYAMRNVYLARNYFAGTEDEDEFV-----DDEVIEKLLNAMDACLLIcnIYSTVSDLQFLQEDNVSHIIKFTQF 610
Cdd:cd23958     1 KLVRLLTILERNIRDGESLDLDLDESQEDDeerlwLLERIDRALEAADASLTI--LTSPGLPKQLYSEDLIERVVDFLKF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  611 QLRETIFPLHDPVYTAKSIKRTTHRKKIKSHQAQNRSMQLFYLKTVELLKVFVTLFDKCVFVDTIVLPLSTLAIEPFFVD 690
Cdd:cd23958    79 QLENTIYPAYDPVYRSDSSAKAGKKKRAKASSKKKKSVSTLLNKLCELLSLLAELLSLQSLTDSVILQLVYLAISPFFVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  691 ----NIETLQFVCLELVTTIFRkeRYDKIRNSILGDILTSIDRLPSSKKNLRPYKLtNNGGNIQMVTALVLQLIQCATIL 766
Cdd:cd23958   159 navsNVDELQLSALKLLTSIFS--RYPDQRQFIIEEILSSLAKLPSSKRNLRQFRL-NDGKSIQMVTALLLQLVQSSVKL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  767 PDSLCDNGKFSNKPQEGNTFDEEgkkllqpsQDLLVLQKYDVAVSIGGNFLTTFLNKC--KSRSNETDFRPLFENFIHDL 844
Cdd:cd23958   236 PNLEKESSRDKSLEEDSDELLED--------EESALAKSYESAVRIASYFLSFLLQKCtkKKKEKDTDYRPLFENFVQDL 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  845 LATVNKPEWPASELLLSLLGTMLVRYVSDKGIEQSIRLVSLDYLGIVAARLRKDTVEsrcrvniidsmiqsikleqekeg 924
Cdd:cd23958   308 LTVLNLPEWPAAELLLSLLGRLLVSIFSNKKTDANARVMALDLLGLIAARLRKDALA----------------------- 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  925 dvtsnndqfdlepeeqrtDFLQKILLDFLAVNAQEENLIWdYARHFYLAQWYRDVIYQRRRINDgkkglafrkskirnnr 1004
Cdd:cd23958   365 ------------------EELQKALLDYLAENSSSDPSLE-SARGFYLAQWLRDLSNELEKAEK---------------- 409

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1005 rtngdyldtsdsgscdesdtdTNKKRIHCVDSNDFELNINIYKALEARKQYfinkikpfsvfgeqnhssnqhIKTYIDYN 1084
Cdd:cd23958   410 ---------------------AAEEEDTILKLELSELRKKFLDSKILSKEE---------------------EASPLSRE 447

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1085 NAQLIAQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRAMKCLANIVEVDPLVLKRKDMQMGVNQKFLDTAISVREAA 1164
Cdd:cd23958   448 DAKLLYRALASQRPLSQSFDPILKQLLSSLDEPAVTLRTKALKALSLVVEADPSILGDPDVQRAVEGRLLDSSASVREAA 527

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1165 VDLVGKFVLSNQDLIDQYYDMLSTRILDTGVSVRKRVIKILRDICLEYPDFSKIPEICVKMIRRVHD-EEGIQKLVTEVF 1243
Cdd:cd23958   528 VELVGKYISSRPDLAEQYYEMIAERILDTGVSVRKRVIKILRDIYLRTPDFEIKVDICVRLLRRINDeEESIKDLARKTF 607

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1244 MKMWFTPCTKN-----DKIGIQRKINHIIDVVNtAHDTGTTWLEGLLMSIFKPrdnmlrsegcvqefikKNSEPPMDIVI 1318
Cdd:cd23958   608 QELWFTPFPESsspaqDKESLAERVLLIVDVVA-ACRKGLDLLEQLLKRLLKS----------------KEDKEDKSVRK 670

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1319 ACQQLADGLVDRLIELE----DTDNSRMLGCITTLHLLAKVRP-QLLVKHAITIEPYLNIKCHSATAAKFICAVADILEK 1393
Cdd:cd23958   671 ACKQLVDCLVELILELEedddESSESDLVACLSTLHLFAKADPkLLLVEHAETLQPYLKSKCSTREDQQVLRYVLRILRS 750

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1394 VVPLVNNASESFLASLEEHLMLLVVSRNQAEVTSCVSCLGALVNKITHNFKLIRDCFQKFYRVLDVSRSQVIQGNNSVDN 1473
Cdd:cd23958   751 VLPLLSHPSESFLEELEEDLLKLLLKHSVTVLQEAIACLCAVVNKLTKNYERLRKALQSCLKLLRKYKRQANLDPSSLKE 830

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1474 IytPSFRRSLFTIGILMRYFDFKSPIALGETNDGL-PVSICEDVFHCLMFFCRC-TNQEIRKQALISLGSFCVLNDGYLT 1551
Cdd:cd23958   831 D--PKLLRLLYILGLLARYCDFDSERDDFEKAPLKtKESVKELVFDLLLFFTKPpIDEDVRKKALQALGFLCIAHPKLFL 908

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1552 RSELKNLYCEILSSiaNDAGFKIICMRNIWIYLTESEMFMHNKEKEWEKQSK-----HEDLKEMNDVSSGMASRIIQLYL 1626
Cdd:cd23958   909 SPEVLKLLDEILAS--GSLKLKLQVLRNLQEFLQAEEKRMEAADAEWKKNSKaadvkVLDGKEMGDADSGVASSIMQRYL 986

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1627 EEILECFLNRDDTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVNMKVQFGLQL 1706
Cdd:cd23958   987 KDILELCLSSDSQVRLAALKVLELILRQGLVHPIQCVPTLIALETDPNPAIRKLALRLLKELHEKYESLVESKYLEGVRL 1066

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1707 CFKLQKILQINNRGKLeiirgyasRGPDNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFDDQ-------KTSLQQMLYI 1779
Cdd:cd23958  1067 AFQYQKRLAGDTRGRG--------FRTDSPPTALLGRLYSLLRGNRKSRRKFLKSLLKLFDFDlkkssdsPSDLDFLLFL 1138

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162 1780 ADNLAYFPYVVQDEPLYLIHQIDLLISMAGTHLLATFkehikpsdkegdvleddddvedpevlfnrlpedlteiikcITS 1859
Cdd:cd23958  1139 AENLAFLPYQTQDEPLFVIHTIDRILSVTGSSLLQAI----------------------------------------AKA 1178

                        1370
                  ....*....|....*...
gi 281360162 1860 AQACMLLLILKDHLKEMY 1877
Cdd:cd23958  1179 SQALLLLLLLKQHLKRLY 1196
Nipped-B_C pfam12830
Sister chromatid cohesion C-terminus; This domain lies towards the C-terminus of nipped-B or ...
 1618-1802 3.25e-53

Sister chromatid cohesion C-terminus; This domain lies towards the C-terminus of nipped-B or sister chromatid cohesion proteins.


Pssm-ID: 463722  Cd Length: 180  Bit Score: 184.66  E-value: 3.25e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  1618 ASRIIQLYLEEILECFLNRDDTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVN 1697
Cdd:pfam12830    1 CSALVQRYLKHILEICLSSDDQVRLLALEVLALILRQGLVHPKECIPTLIALETSPNPYIRKLAFELHKELHEKHESLLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360162  1698 MKVQFGLQLCFKLQKILQINNRGkleiirgyasrgpdNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFDD-------QK 1770
Cdd:pfam12830   81 SRYMEGIRLAFEYQRRVLSGATL--------------EPPTSFLSLLYSLLRSNKKSRKKFLKSLVKLFFDldlssesSP 146

                          170       180       190
                   ....*....|....*....|....*....|..
gi 281360162  1771 TSLQQMLYIADNLAYFPYVVQDEPLYLIHQID 1802
Cdd:pfam12830  147 SDLDFLRFLAENLAFLPYQTQDEVLFLIHHID 178
Cohesin_HEAT pfam12765
HEAT repeat associated with sister chromatid cohesion; This HEAT repeat is found most ...
 1127-1168 4.03e-06

HEAT repeat associated with sister chromatid cohesion; This HEAT repeat is found most frequently in sister chromatid cohesion proteins such as Nipped-B. HEAT repeats are found tandemly repeated in many proteins, and they appear to serve as flexible scaffolding on which other components can assemble.


Pssm-ID: 403845 [Multi-domain]  Cd Length: 42  Bit Score: 45.14  E-value: 4.03e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281360162  1127 KCLANIVEVDPLVLKRKDMQMGVNQKFLDTAISVREAAVDLV 1168
Cdd:pfam12765    1 KALSSLVEKDPSILDSPDVKEAISRRLTDSSPSVRDAALELL 42
PDS5 pfam20168
Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid ...
 1151-1229 7.56e-03

Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid cohesion protein PDS5. The large PDS5 molecule is exclusively alpha helical, composed of a large number of HEAT-like repeats and helical extensions/additions that deviate from the HEAT repeat pattern.


Pssm-ID: 466319 [Multi-domain]  Cd Length: 1051  Bit Score: 41.42  E-value: 7.56e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281360162  1151 QKFLDTAISVREAAVDLVGKFVLSNQDLIDQYYDMLSTRILDTGVSVRKRVIKILRDicLEYPDFSKIPeiCVKMIRRV 1229
Cdd:pfam20168  291 GRFNDKSVAVRIAWVEAAKQILLNHPDLRSEILEALKDRLLDPDEKVRLAAVKAIGD--LDYETLLHVV--SEKLLKTL 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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