uncharacterized protein Dmel_CG1620, isoform B [Drosophila melanogaster]
Protein Classification
ELM2 and SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10477696)
ELM2 and SANT/Myb-like DNA-binding domain-containing protein similar to REST corepressor 3, may act as a component of a corepressor complex that represses transcription
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| SANT super family | cl21498 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
417-450 | 1.01e-10 | ||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. The actual alignment was detected with superfamily member cd11661: Pssm-ID: 473887 [Multi-domain] Cd Length: 46 Bit Score: 56.47 E-value: 1.01e-10
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| ELM2 | pfam01448 | ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
275-325 | 4.44e-09 | ||
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain. : Pssm-ID: 460214 Cd Length: 53 Bit Score: 52.23 E-value: 4.44e-09
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| Name | Accession | Description | Interval | E-value | ||
| SANT_MTA3_like | cd11661 | Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
417-450 | 1.01e-10 | ||
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis. Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 56.47 E-value: 1.01e-10
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| ELM2 | pfam01448 | ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
275-325 | 4.44e-09 | ||
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain. Pssm-ID: 460214 Cd Length: 53 Bit Score: 52.23 E-value: 4.44e-09
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| Name | Accession | Description | Interval | E-value | ||
| SANT_MTA3_like | cd11661 | Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
417-450 | 1.01e-10 | ||
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis. Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 56.47 E-value: 1.01e-10
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| ELM2 | pfam01448 | ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
275-325 | 4.44e-09 | ||
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain. Pssm-ID: 460214 Cd Length: 53 Bit Score: 52.23 E-value: 4.44e-09
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