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Conserved domains on  [gi|281363687|ref|NP_001163196|]
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uncharacterized protein Dmel_CG30122, isoform C [Drosophila melanogaster]

Protein Classification

SAP domain-containing protein( domain architecture ID 13670111)

SAP domain-containing protein similar to Rattus norvegicus SAP domain-containing ribonucleoprotein that specifically binds to scaffold/matrix attachment region DNA and also binds single-stranded RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRY_hnRNP cd12884
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ...
 300-480 2.41e-81

SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation.


:

Pssm-ID: 293942  Cd Length: 177  Bit Score: 264.07  E-value: 2.41e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  300 VGLSWLDSDLHLRIDPTTFaSAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSEEsvPENSHYFRDEPHVRGFRVGFS 379
Cdd:cd12884     1 VCLDTYNSDLHLKISKDRY-SASPLTDEGFAYLWAGARATYGVTKGKVCFEVKVTEN--LPVKHLPTEETDPHVVRVGWS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  380 MPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLESEPCTINYTLNGEDLGVAFEFEKSILGEEgA 459
Cdd:cd12884    78 VDSSSLQLGEEEFSYGYGSTGKKSTNCKFEDYGEPFGENDVIGCYLDFESEPVEISFSKNGKDLGVAFKISKEELGGK-A 156

                         170       180
                  ....*....|....*....|.
gi 281363687  460 LFPHIVTKGYEYLVNFSDTEQ 480
Cdd:cd12884   157 LFPHVLTKNCAVEVNFGQKEE 177
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 709-855 2.13e-33

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 125.89  E-value: 2.13e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   709 VILLVGLPGAGKTHWAHKHVAENAdkrYELIGPDAFISKMTIDGASRKTVHKGRWDKVYEIclnsLAALEDIAMKRRRNF 788
Cdd:pfam13671    1 LILLVGLPGSGKSTLARRLLEELG---AVRLSSDDERKRLFGEGRPSISYYTDATDRTYER----LHELARIALRAGRPV 73

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   789 ILDQTNVYASAQRRKMKGFND--FKRIAVVCIPSEDELKRRIAEKEEKGN-AFTVKESTINNLRANFTLP 855
Cdd:pfam13671   74 ILDATNLRRDERARLLALAREygVPVRIVVFEAPEEVLRERLAARARAGGdPSDVPEEVLDRQKARFEPP 143
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 6-40 6.53e-11

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


:

Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 58.18  E-value: 6.53e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 281363687     6 LEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYV 40
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
PTZ00121 super family cl31754
MAEBL; Provisional
 520-677 2.38e-07

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 2.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  520 EATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSET 599
Cdd:PTZ00121 1351 EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEK 1430

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281363687  600 AAVSNGDAAAEQAndEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTA 677
Cdd:PTZ00121 1431 KKADEAKKKAEEA--KKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAA 1506
PLN03124 super family cl33640
poly [ADP-ribose] polymerase; Provisional
 8-168 8.39e-06

poly [ADP-ribose] polymerase; Provisional


The actual alignment was detected with superfamily member PLN03124:

Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 50.22  E-value: 8.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687    8 KMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVtpsrrqrrTRSMSRSPSPVQAAPVAAEPVLDTLEE 87
Cdd:PLN03124    4 KLKVDELRAALAKRGLDTTGLKAALVRRLDDAIAEDAKTASKSGT--------KSSAGRKKRRERQDDGDDEPVSPKRIA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   88 EEQPEDKTVPQPepeseQPAAEPEPEQSEPEEAEPAAAVTEDTTVNQAVneeSQPEPEEFDEKSETDDKQETIEEAVPAV 167
Cdd:PLN03124   76 IDEVKGMTVREL-----REAASERGLATTGRKKDLLERLCAALESDVKV---GSANGTGEDEKEKGGDEEREKEEKIVTA 147


                  .
gi 281363687  168 V 168
Cdd:PLN03124  148 T 148
SF-CC1 super family cl36939
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 1036-1108 6.98e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


The actual alignment was detected with superfamily member TIGR01622:

Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 40.67  E-value: 6.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  1036 GYDDRGYGSSRDY-------RDRDRGNDRSRMGSNDRNRGSSQSSYRsgggtHQQRD-FRPGHRDTKEDSRGGYERSAGQ 1107
Cdd:TIGR01622    1 RYRDRERERLRDSssagdrdRRRDKGRERSRDRSRDRERSRSRRRDR-----HRDRDyYRGRERRSRSRRPNRRYRPREK 75


                   .
gi 281363687  1108 S 1108
Cdd:TIGR01622   76 R 76
 
Name Accession Description Interval E-value
SPRY_hnRNP cd12884
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ...
 300-480 2.41e-81

SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation.


Pssm-ID: 293942  Cd Length: 177  Bit Score: 264.07  E-value: 2.41e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  300 VGLSWLDSDLHLRIDPTTFaSAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSEEsvPENSHYFRDEPHVRGFRVGFS 379
Cdd:cd12884     1 VCLDTYNSDLHLKISKDRY-SASPLTDEGFAYLWAGARATYGVTKGKVCFEVKVTEN--LPVKHLPTEETDPHVVRVGWS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  380 MPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLESEPCTINYTLNGEDLGVAFEFEKSILGEEgA 459
Cdd:cd12884    78 VDSSSLQLGEEEFSYGYGSTGKKSTNCKFEDYGEPFGENDVIGCYLDFESEPVEISFSKNGKDLGVAFKISKEELGGK-A 156

                         170       180
                  ....*....|....*....|.
gi 281363687  460 LFPHIVTKGYEYLVNFSDTEQ 480
Cdd:cd12884   157 LFPHVLTKNCAVEVNFGQKEE 177
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 709-855 2.13e-33

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 125.89  E-value: 2.13e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   709 VILLVGLPGAGKTHWAHKHVAENAdkrYELIGPDAFISKMTIDGASRKTVHKGRWDKVYEIclnsLAALEDIAMKRRRNF 788
Cdd:pfam13671    1 LILLVGLPGSGKSTLARRLLEELG---AVRLSSDDERKRLFGEGRPSISYYTDATDRTYER----LHELARIALRAGRPV 73

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   789 ILDQTNVYASAQRRKMKGFND--FKRIAVVCIPSEDELKRRIAEKEEKGN-AFTVKESTINNLRANFTLP 855
Cdd:pfam13671   74 ILDATNLRRDERARLLALAREygVPVRIVVFEAPEEVLRERLAARARAGGdPSDVPEEVLDRQKARFEPP 143
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 363-475 3.59e-14

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 70.06  E-value: 3.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   363 HYF-----RDEPHvrGFRVGFSMP----KSSLLLGEAEHSFGYC-ETGRKATQSEFTDYGKP-YQLDDVIGCYLDLESEp 431
Cdd:pfam00622    2 HYFeveifGQDGG--GWRVGWATKsvprKGERFLGDESGSWGYDgWTGKKYWASTSPLTGLPlFEPGDVIGCFLDYEAG- 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 281363687   432 cTINYTLNGEDLGVAFefekSILGEEGALFPHI-VTKGYEYLVNF 475
Cdd:pfam00622   79 -TISFTKNGKSLGYAF----RDVPFAGPLFPAVsLGAGEGLKFNF 118
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 345-475 4.19e-13

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 67.32  E-value: 4.19e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687    345 GKVCFEVRLSEESvpenshyfrdephvrGFRVGFSMPKSSL----LLGEAEHSFGYC-ETGRKATQSEFTDYGKPYQL-D 418
Cdd:smart00449    2 GRHYFEVEIGDGG---------------HWRVGVATKSVPRgyfaLLGEDKGSWGYDgDGGKKYHNSTGPEYGLPLQEpG 66

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 281363687    419 DVIGCYLDLESEpcTINYTLNGEDL-GVAFefeKSILGEEGaLFPHIVTKGYEYL-VNF 475
Cdd:smart00449   67 DVIGCFLDLEAG--TISFYKNGKYLhGLAF---FDVKFSGP-LYPAFSLGSGNSVrLNF 119
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 6-40 6.53e-11

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 58.18  E-value: 6.53e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 281363687     6 LEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYV 40
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
COG4639 COG4639
Predicted kinase [General function prediction only];
706-830 2.12e-10

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 60.23  E-value: 2.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  706 ECEVILLVGLPGAGKTHWAHKHVAEnadkrYELIGPDAFISKMTIDGASRKTvhkgrWDKVyeiclnsLAALEDIA---M 782
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRLFAP-----TEVVSSDDIRALLGGDENDQSA-----WGDV-------FQLAHEIArarL 63

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281363687  783 KRRRNFILDQTNVYASAqRRKMKG-FNDFKR--IAVVCIPSEDELKRRIAE 830
Cdd:COG4639    64 RAGRLTVVDATNLQREA-RRRLLAlARAYGAlvVAVVLDVPLEVCLARNAA 113
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
6-40 7.73e-10

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 55.19  E-value: 7.73e-10
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 281363687      6 LEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYV 40
Cdd:smart00513    1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
PTZ00121 PTZ00121
MAEBL; Provisional
 520-677 2.38e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 2.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  520 EATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSET 599
Cdd:PTZ00121 1351 EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEK 1430

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281363687  600 AAVSNGDAAAEQAndEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTA 677
Cdd:PTZ00121 1431 KKADEAKKKAEEA--KKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAA 1506
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 520-679 5.73e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 50.76  E-value: 5.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   520 EATADDDEVEKKDEDgKASSEKDEEEAEdpEKAKEDeAAPKTETEAETKVEAPAE-AAKPESEATEASETAETSTEKSSE 598
Cdd:TIGR00927  756 ETEGDRKETEHEGET-EAEGKEDEDEGE--IQAGED-GEMKGDEGAEGKVEHEGEtEAGEKDEHEGQSETQADDTEVKDE 831

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   599 TA-AVSNGDAAAEQANDEKASEDKKPSENNDEEDEDgpspnkrpktDGDSEKAESEKEKDRSQTTEDEYEDVV----PEP 673
Cdd:TIGR00927  832 TGeQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEE----------EEEEEEEEEEEEEEEEEEEEEENEEPLslewPET 901


                   ....*.
gi 281363687   674 RDTAAL 679
Cdd:TIGR00927  902 RQKQAI 907
PLN03124 PLN03124
poly [ADP-ribose] polymerase; Provisional
 8-168 8.39e-06

poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 50.22  E-value: 8.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687    8 KMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVtpsrrqrrTRSMSRSPSPVQAAPVAAEPVLDTLEE 87
Cdd:PLN03124    4 KLKVDELRAALAKRGLDTTGLKAALVRRLDDAIAEDAKTASKSGT--------KSSAGRKKRRERQDDGDDEPVSPKRIA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   88 EEQPEDKTVPQPepeseQPAAEPEPEQSEPEEAEPAAAVTEDTTVNQAVneeSQPEPEEFDEKSETDDKQETIEEAVPAV 167
Cdd:PLN03124   76 IDEVKGMTVREL-----REAASERGLATTGRKKDLLERLCAALESDVKV---GSANGTGEDEKEKGGDEEREKEEKIVTA 147


                  .
gi 281363687  168 V 168
Cdd:PLN03124  148 T 148
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 518-643 1.12e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 43.24  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  518 LDEATADDDEVEKKDEDgkassEKDEEEAEDPEKAKEDEAAPKTETEAETkveapAEAAKPESEATEaSETAETSTEKSS 597
Cdd:COG4547   207 LAEELGEDEDEEDEDDE-----DDSGEQEEDEEDGEDEDEESDEGAEAED-----AEASGDDAEEGE-SEAAEAESDEMA 275

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 281363687  598 ETAAVSNGDAAAEqandekasedkkPSENNDEEDEDGPSPNKRPKT 643
Cdd:COG4547   276 EEAEGEDSEEPGE------------PWRPNAPPPDDPADPDYKVFT 309
PNK-3'Pase TIGR01663
polynucleotide 5'-kinase 3'-phosphatase; This model represents the metazoan 5 ...
 707-874 1.67e-03

polynucleotide 5'-kinase 3'-phosphatase; This model represents the metazoan 5'-polynucleotide-kinase-3'-phosphatase, PNKP, which is believed to be involved in repair of oxidative DNA damage. Removal of 3' phosphates is essential for the further processing of the break by DNA polymerases. The central phosphatase domain is a member of the IIIA subfamily (TIGR01662) of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. As is common in this superfamily, the enzyme is magnesium dependent. A difference between this enzyme and other HAD-superfamily phosphatases is in the third conserved catalytic motif which usually contains two conserved aspartate residues believed to be involved in binding the magnesium ion. Here, the second aspartate is replaced by a conserved arginine residue which may indicate an interaction with the phosphate backbone of the substrate. Very close relatives of this domain are also found separate from the N- and C-terminal domains seen here, as in the 3'-phosphatase found in plants. The larger family of these domains is described by TIGR01664. Outside of the phosphatase domain is a P-loop ATP-binding motif associated with the kinase activity. The entry for the mouse homolog appears to be missing a large piece of sequence corresponding to the first conserved catalytic motif of the phosphatase domain as well as the conserved threonine of the second motif. Either this is a sequencing artifact or this may represent a pseudo- or non-functional gene. Note that the EC number for the kinase function is: 2.7.1.78


Pssm-ID: 130724 [Multi-domain]  Cd Length: 526  Bit Score: 42.70  E-value: 1.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   707 CEVILLVGLPGAGKTHWAHKHVAENAdkrYELIGPDAFiskmtidgasrktvhkGRWDKVYEIClnslaaleDIAMKRRR 786
Cdd:TIGR01663  369 CEMVIAVGFPGAGKSHFCKKFFQPAG---YKHVNADTL----------------GSTQNCLTAC--------ERALDQGK 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   787 NFILDQTNVYASAQRRKMKGFNDFK---RIAVVCIPSEdELKRRIAEKEEKGNAFT-VKESTINNLRANFTLPSLEFGWF 862
Cdd:TIGR01663  422 RCAIDNTNPDAASRAKFLQCARAAGipcRCFLFNAPLA-QAKHNIAFRELSDSAHIkIKDMVFNGMKKKFEAPALAEGFI 500

                          170
                   ....*....|....
gi 281363687   863 D--DINYTELTGDE 874
Cdd:TIGR01663  501 AihEINFKPLFADE 514
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 476-668 2.76e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 42.20  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  476 SDTEQLLVNAERPTRKRRKPRKDEDKDKDDDKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKED 555
Cdd:NF033609  567 SDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDS 646

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  556 EAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGP 635
Cdd:NF033609  647 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 726

                         170       180       190
                  ....*....|....*....|....*....|...
gi 281363687  636 SPNKRPKTDGDSEKAESEKEKDRSQTTEDEYED 668
Cdd:NF033609  727 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 759
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 527-609 4.25e-03

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 39.81  E-value: 4.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   527 EVEKKDEDGKASSEKDE---EEAEdPEKAKEDEAAPKTETEAETKVEAPAEAAK---------PESEATEAS--ETAETS 592
Cdd:pfam14962   95 EKENVAEAEKASSEAPEvsvVEAE-VVDAEEIPDATAAVIEEASACPGDVEAAPvettavgaeTGPEVTDAAtgETTEVS 173

                           90
                   ....*....|....*..
gi 281363687   593 TEKSSETAAVSNGDAAA 609
Cdd:pfam14962  174 AETTPEVTSAAPDEAVA 190
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 1036-1108 6.98e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 40.67  E-value: 6.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  1036 GYDDRGYGSSRDY-------RDRDRGNDRSRMGSNDRNRGSSQSSYRsgggtHQQRD-FRPGHRDTKEDSRGGYERSAGQ 1107
Cdd:TIGR01622    1 RYRDRERERLRDSssagdrdRRRDKGRERSRDRSRDRERSRSRRRDR-----HRDRDyYRGRERRSRSRRPNRRYRPREK 75


                   .
gi 281363687  1108 S 1108
Cdd:TIGR01622   76 R 76
 
Name Accession Description Interval E-value
SPRY_hnRNP cd12884
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ...
 300-480 2.41e-81

SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation.


Pssm-ID: 293942  Cd Length: 177  Bit Score: 264.07  E-value: 2.41e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  300 VGLSWLDSDLHLRIDPTTFaSAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSEEsvPENSHYFRDEPHVRGFRVGFS 379
Cdd:cd12884     1 VCLDTYNSDLHLKISKDRY-SASPLTDEGFAYLWAGARATYGVTKGKVCFEVKVTEN--LPVKHLPTEETDPHVVRVGWS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  380 MPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLESEPCTINYTLNGEDLGVAFEFEKSILGEEgA 459
Cdd:cd12884    78 VDSSSLQLGEEEFSYGYGSTGKKSTNCKFEDYGEPFGENDVIGCYLDFESEPVEISFSKNGKDLGVAFKISKEELGGK-A 156

                         170       180
                  ....*....|....*....|.
gi 281363687  460 LFPHIVTKGYEYLVNFSDTEQ 480
Cdd:cd12884   157 LFPHVLTKNCAVEVNFGQKEE 177
SPRY_DDX1 cd12873
SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD ...
 302-478 2.11e-36

SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD box gene, DDX1, an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication. It is suggested that DDX1 acts as a cellular cofactor by promoting oligomerization of Rev on the Rev response element (RRE). DDX1 RNA is overexpressed in breast cancer, data showing a strong and independent association between poor prognosis and deregulation of the DEAD box protein DDX1, thus potentially serving as an effective prognostic biomarker for early recurrence in primary breast cancer. DDX1 also interacts with RelA and enhances nuclear factor kappaB-mediated transcription. DEAD-box proteins are associated with all levels of RNA metabolism and function, and have been implicated in translation initiation, transcription, RNA splicing, ribosome assembly, RNA transport, and RNA decay.


Pssm-ID: 293933  Cd Length: 155  Bit Score: 135.01  E-value: 2.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  302 LSWLDSDLHLRIDPT-TFASAKPLTSeiysliWSGARANYGVRE-GKVCFEVRLSEEsvpenshyfrdephvrGF-RVGF 378
Cdd:cd12873     1 MNPYDRDAALAISPDgLLCQSREEKG------WQGCRATKGVKGkGKYYYEVTVTDE----------------GLcRVGW 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  379 SMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLESEpcTINYTLNGEDLGVAFEFEKSILGEeg 458
Cdd:cd12873    59 STEDASLDLGTDKFGFGYGGTGKKSHGRQFDDYGEPFGLGDVIGCYLDLDNG--TISFSKNGKDLGKAFDIPPHLRNS-- 134

                         170       180
                  ....*....|....*....|
gi 281363687  459 ALFPHIVTKGYEYLVNFSDT 478
Cdd:cd12873   135 ALFPAVCLKNAEVEFNFGDK 154
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 709-855 2.13e-33

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 125.89  E-value: 2.13e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   709 VILLVGLPGAGKTHWAHKHVAENAdkrYELIGPDAFISKMTIDGASRKTVHKGRWDKVYEIclnsLAALEDIAMKRRRNF 788
Cdd:pfam13671    1 LILLVGLPGSGKSTLARRLLEELG---AVRLSSDDERKRLFGEGRPSISYYTDATDRTYER----LHELARIALRAGRPV 73

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   789 ILDQTNVYASAQRRKMKGFND--FKRIAVVCIPSEDELKRRIAEKEEKGN-AFTVKESTINNLRANFTLP 855
Cdd:pfam13671   74 ILDATNLRRDERARLLALAREygVPVRIVVFEAPEEVLRERLAARARAGGdPSDVPEEVLDRQKARFEPP 143
SPRY_Ash2 cd12872
SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or ...
 333-448 1.21e-18

SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or homeotic discs 2) -like proteins, core components of all mixed-lineage leukemia (MLL) family histone methyltransferases. Ash2 is a member of the trithorax group of transcriptional regulators of the Hox genes. Recent studies show that the SPRY domain of Ash2 mediates the interaction with RbBP5 and has an important role in regulating the methyltransferase activity of MLL complexes. In yeast, Ash2 is involved in histone methylation and is required for the earliest stages of embryogenesis.


Pssm-ID: 293932  Cd Length: 150  Bit Score: 84.11  E-value: 1.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  333 WSGARANYGVREGKVCFEVRLSEESVPENSHYfrdephvrgfRVGFSMPKSSLllgEA-----EHSFGYCE-TGRKATQS 406
Cdd:cd12872    16 YRMARANHGVREGKWYFEVKILEGGGTETGHV----------RVGWSRREASL---QApvgydKYSYAIRDkDGSKFHQS 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 281363687  407 EFTDYGKP-YQLDDVIGCYLDLESepctINYTLNGEDLGVAFE 448
Cdd:cd12872    83 RGKPYGEPgFKEGDVIGFLITLPK----IEFFKNGKSQGVAFE 121
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 345-465 1.23e-14

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 71.31  E-value: 1.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  345 GKVCFEVRLseesvpenshyfrDEPHVRGFRVGFSMPKSSL----LLGEAEHSFGY-CETGRKATQSEFTDYGKPYQLDD 419
Cdd:cd11709     1 GKWYWEVRV-------------DSGNGGLIQVGWATKSFSLdgegGVGDDEESWGYdGSRLRKGHGGSSGPGGRPWKSGD 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 281363687  420 VIGCYLDLESEpcTINYTLNGEDLGVAFEfekSILGEEGALFPHIV 465
Cdd:cd11709    68 VVGCLLDLDEG--TLSFSLNGKDLGVAFT---NLFLKGGGLYPAVS 108
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 363-475 3.59e-14

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 70.06  E-value: 3.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   363 HYF-----RDEPHvrGFRVGFSMP----KSSLLLGEAEHSFGYC-ETGRKATQSEFTDYGKP-YQLDDVIGCYLDLESEp 431
Cdd:pfam00622    2 HYFeveifGQDGG--GWRVGWATKsvprKGERFLGDESGSWGYDgWTGKKYWASTSPLTGLPlFEPGDVIGCFLDYEAG- 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 281363687   432 cTINYTLNGEDLGVAFefekSILGEEGALFPHI-VTKGYEYLVNF 475
Cdd:pfam00622   79 -TISFTKNGKSLGYAF----RDVPFAGPLFPAVsLGAGEGLKFNF 118
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 345-475 4.19e-13

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 67.32  E-value: 4.19e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687    345 GKVCFEVRLSEESvpenshyfrdephvrGFRVGFSMPKSSL----LLGEAEHSFGYC-ETGRKATQSEFTDYGKPYQL-D 418
Cdd:smart00449    2 GRHYFEVEIGDGG---------------HWRVGVATKSVPRgyfaLLGEDKGSWGYDgDGGKKYHNSTGPEYGLPLQEpG 66

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 281363687    419 DVIGCYLDLESEpcTINYTLNGEDL-GVAFefeKSILGEEGaLFPHIVTKGYEYL-VNF 475
Cdd:smart00449   67 DVIGCFLDLEAG--TISFYKNGKYLhGLAF---FDVKFSGP-LYPAFSLGSGNSVrLNF 119
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 6-40 6.53e-11

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 58.18  E-value: 6.53e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 281363687     6 LEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYV 40
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
COG4639 COG4639
Predicted kinase [General function prediction only];
706-830 2.12e-10

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 60.23  E-value: 2.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  706 ECEVILLVGLPGAGKTHWAHKHVAEnadkrYELIGPDAFISKMTIDGASRKTvhkgrWDKVyeiclnsLAALEDIA---M 782
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRLFAP-----TEVVSSDDIRALLGGDENDQSA-----WGDV-------FQLAHEIArarL 63

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281363687  783 KRRRNFILDQTNVYASAqRRKMKG-FNDFKR--IAVVCIPSEDELKRRIAE 830
Cdd:COG4639    64 RAGRLTVVDATNLQREA-RRRLLAlARAYGAlvVAVVLDVPLEVCLARNAA 113
SPRY_RanBP_like cd12885
SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY ...
 349-475 4.53e-10

SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY domains found in Ran binding proteins (RBP or RanBPM) 9 and 10, SSH4 (suppressor of SHR3 null mutation protein 4), SPRY domain-containing protein 3 (SPRYD3) as well as HECT, a C-terminal catalytic domain of a subclass of ubiquitin-protein ligase (E3). RanBP9 and RanBP10 act as androgen receptor (AR) coactivators. Both consist of the N-terminal proline- and glutamine-rich regions, the SPRY domain, and LisH-CTLH and CRA motifs. The SPRY domain in SSH4 may be involved in cargo recognition, either directly or by combination with other adaptors, possibly leading to a higher selectivity. SPRYD3 is highly expressed in most tissues in humans, possibly involved in important cellular processes. HECT E3 mediates the direct transfer of ubiquitin from E2 to substrate.


Pssm-ID: 293943  Cd Length: 132  Bit Score: 58.83  E-value: 4.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  349 FEVRLseESVPENSHyfrdephvrgFRVGFSMPKSSL--LLGEAEHSFGYC-ETGRK-ATQSEFTDYGKPYQLDDVIGCY 424
Cdd:cd12885    18 FEVTI--LDLGEKGI----------VSIGFCTSGFPLnrMPGWEDGSYGYHgDDGRVyLGGGEGENYGPPFGTGDVVGCG 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 281363687  425 LDLESEpcTINYTLNGEDLGVAFEFEKSilgeeGALFP--HIVTKGYEYLVNF 475
Cdd:cd12885    86 INFKTG--EVFFTKNGELLGTAFENVVK-----GRLYPtvGLGSPGVKVRVNF 131
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
6-40 7.73e-10

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 55.19  E-value: 7.73e-10
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 281363687      6 LEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYV 40
Cdd:smart00513    1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
SPRY_RNF123 cd12882
SPRY domain at N-terminus of ring finger protein 123; This SPRY domain is found at the ...
 336-464 7.33e-09

SPRY domain at N-terminus of ring finger protein 123; This SPRY domain is found at the N-terminus of RING finger protein 123 domain (also known as E3 ubiquitin-protein ligase RNF123). The ring finger domain motif is present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RNF123 displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor p27 (Kip1).


Pssm-ID: 293940  Cd Length: 128  Bit Score: 55.41  E-value: 7.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  336 ARANYGVREGKVCFEVRLSEESVPE-----NSHYFRDEPHVrgfrvgfsmpksslllGEAEHSFGYCETGRKATQSEFTD 410
Cdd:cd12882     2 IRANACVYKGKWMYEVTLGTKGIMQigwatISCRFTQEEGV----------------GDTRDSYAYDGNRVRKWNVSTQK 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 281363687  411 YGKPYQLDDVIGCYLDLESEpcTINYTLNGEDLGVAFEFEKSILGEegALFPHI 464
Cdd:cd12882    66 YGEPWVAGDVIGCCIDLDKG--TISFYRNGRSLGVAFDNVRRGPGL--AYFPAV 115
SPRY_RanBP9_10 cd12909
SPRY domain in Ran binding proteins 9 and 10; This family includes SPRY domain in Ran binding ...
 376-475 1.69e-08

SPRY domain in Ran binding proteins 9 and 10; This family includes SPRY domain in Ran binding protein (RBP or RanBPM) 9 and 10, and similar proteins. RanBP9 (also known as RanBPM), a binding partner of Ran, is a small Ras-like GTPase that exerts multiple functions via interactions with various proteins. RanBP9 and RanBP10 also act as androgen receptor (AR) coactivators. Both consist of the N-terminal proline- and glutamine-rich regions, the SPRY domain, and LisH-CTLH and CRA motifs. SPRY domain of RanBPM forms a complex with CD39, a prototypic member of the NTPDase family, thus down-regulating activity substantially. RanBP10 enhances the transcriptional activity of AR in a ligand-dependent manner and exhibits a protein expression pattern different from RanBPM in various cell lines. RanBP10 is highly expressed in AR-positive prostate cancer LNCaP cells, while RanBPM is abundant in WI-38 and MCF-7 cells.


Pssm-ID: 293966  Cd Length: 144  Bit Score: 54.45  E-value: 1.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  376 VGFSMPKSSL--LLGEAEHSFGY----------CETGRKatqseftdYGKPYQLDDVIGCYLDLESEpcTINYTLNGEDL 443
Cdd:cd12909    44 IGFSTKDVNLnrLPGWEPHSWGYhgddghsfcsSGTGKP--------YGPTFTTGDVIGCGINFRDN--TAFYTKNGVNL 113

                          90       100       110
                  ....*....|....*....|....*....|....
gi 281363687  444 GVAFEFEKsilgeEGALFPHI--VTKGYEYLVNF 475
Cdd:cd12909   114 GIAFRDIK-----KGNLYPTVglRTPGEHVEANF 142
PTZ00121 PTZ00121
MAEBL; Provisional
 520-677 2.38e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 2.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  520 EATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSET 599
Cdd:PTZ00121 1351 EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEK 1430

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281363687  600 AAVSNGDAAAEQAndEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTA 677
Cdd:PTZ00121 1431 KKADEAKKKAEEA--KKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAA 1506
PTZ00121 PTZ00121
MAEBL; Provisional
 526-665 2.92e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.15  E-value: 2.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  526 DEVEKKDEDGKASSEKDEEEAEdpEKAKEDEAAPKTETEAETKVEAPAEAAKP-ESEATEASETAETSTEKSSETAAVSN 604
Cdd:PTZ00121 1318 DEAKKKAEEAKKKADAAKKKAE--EAKKAAEAAKAEAEAAADEAEAAEEKAEAaEKKKEEAKKKADAAKKKAEEKKKADE 1395

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281363687  605 GDAAAEQaNDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDE 665
Cdd:PTZ00121 1396 AKKKAEE-DKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEE 1455
PTZ00121 PTZ00121
MAEBL; Provisional
 516-677 3.99e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.76  E-value: 3.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  516 KVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEdeAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEK 595
Cdd:PTZ00121 1329 KKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAE--AAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKK 1406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  596 SSETAAVSNGDAAAEQANDE-----KASEDKKPSENNDEEDEDGPSPNKRPKTDG------DSEKAESEKEKDRSQTTED 664
Cdd:PTZ00121 1407 ADELKKAAAAKKKADEAKKKaeekkKADEAKKKAEEAKKADEAKKKAEEAKKAEEakkkaeEAKKADEAKKKAEEAKKAD 1486

                         170
                  ....*....|...
gi 281363687  665 EYEDVVPEPRDTA 677
Cdd:PTZ00121 1487 EAKKKAEEAKKKA 1499
SPRY2_RyR cd12878
SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of ...
 336-448 4.39e-07

SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1


Pssm-ID: 240458  Cd Length: 133  Bit Score: 50.38  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  336 ARANYGVREGKVCFEVrlseesvpenshyfrdEPHVRGF-RVGFSMP--KSSLLLGEAEHSFGYceTGRKATQ----SEF 408
Cdd:cd12878     5 AEKTYAVTSGKWYFEF----------------EVLTSGYmRVGWARPgfRPDLELGSDDLSYAF--DGFLARKwhqgSES 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 281363687  409 tdYGKPYQLDDVIGCYLDLESEpcTINYTLNGE----DLG--VAFE 448
Cdd:cd12878    67 --FGKQWQPGDVVGCMLDLVDR--TISFTLNGEllidSSGseVAFK 108
PTZ00121 PTZ00121
MAEBL; Provisional
 519-656 1.96e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.45  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  519 DEATADDDEVEKKDEDGKASSE---KDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASEtAETSTEK 595
Cdd:PTZ00121 1374 EEAKKKADAAKKKAEEKKKADEakkKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKK-ADEAKKK 1452

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281363687  596 SSETAAVSNGDAAAEQAndEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEK 656
Cdd:PTZ00121 1453 AEEAKKAEEAKKKAEEA--KKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKK 1511
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 520-666 3.12e-06

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 51.13  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  520 EATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAEtkveapAEAAKPESEATEASETAETstEKSSET 599
Cdd:PRK13108  322 EPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSE------ADIEREQPGDLAGQAPAAH--QVDAEA 393

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281363687  600 AAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEY 666
Cdd:PRK13108  394 ASAAPEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDDPAEPDGIRRQDDFSSRRRRW 460
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 520-679 5.73e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 50.76  E-value: 5.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   520 EATADDDEVEKKDEDgKASSEKDEEEAEdpEKAKEDeAAPKTETEAETKVEAPAE-AAKPESEATEASETAETSTEKSSE 598
Cdd:TIGR00927  756 ETEGDRKETEHEGET-EAEGKEDEDEGE--IQAGED-GEMKGDEGAEGKVEHEGEtEAGEKDEHEGQSETQADDTEVKDE 831

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   599 TA-AVSNGDAAAEQANDEKASEDKKPSENNDEEDEDgpspnkrpktDGDSEKAESEKEKDRSQTTEDEYEDVV----PEP 673
Cdd:TIGR00927  832 TGeQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEE----------EEEEEEEEEEEEEEEEEEEEEENEEPLslewPET 901


                   ....*.
gi 281363687   674 RDTAAL 679
Cdd:TIGR00927  902 RQKQAI 907
PLN03124 PLN03124
poly [ADP-ribose] polymerase; Provisional
 8-168 8.39e-06

poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 50.22  E-value: 8.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687    8 KMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVtpsrrqrrTRSMSRSPSPVQAAPVAAEPVLDTLEE 87
Cdd:PLN03124    4 KLKVDELRAALAKRGLDTTGLKAALVRRLDDAIAEDAKTASKSGT--------KSSAGRKKRRERQDDGDDEPVSPKRIA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   88 EEQPEDKTVPQPepeseQPAAEPEPEQSEPEEAEPAAAVTEDTTVNQAVneeSQPEPEEFDEKSETDDKQETIEEAVPAV 167
Cdd:PLN03124   76 IDEVKGMTVREL-----REAASERGLATTGRKKDLLERLCAALESDVKV---GSANGTGEDEKEKGGDEEREKEEKIVTA 147


                  .
gi 281363687  168 V 168
Cdd:PLN03124  148 T 148
PTZ00121 PTZ00121
MAEBL; Provisional
 526-674 9.10e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.52  E-value: 9.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  526 DEVEKKDEDGKASSEKDEEEAEDP--EKAKEDEAAPKTEtEAETKVEA---PAEAAKPESEATEASETAETSTEKSSETA 600
Cdd:PTZ00121 1287 EEKKKADEAKKAEEKKKADEAKKKaeEAKKADEAKKKAE-EAKKKADAakkKAEEAKKAAEAAKAEAEAAADEAEAAEEK 1365

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281363687  601 AVSNGDAAAE-----QANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPR 674
Cdd:PTZ00121 1366 AEAAEKKKEEakkkaDAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAK 1444
PTZ00121 PTZ00121
MAEBL; Provisional
 520-656 1.17e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  520 EATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSET 599
Cdd:PTZ00121 1269 QAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA 1348

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 281363687  600 AAVSNGDAAAEQANDEKASEDK-KPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEK 656
Cdd:PTZ00121 1349 KAEAEAAADEAEAAEEKAEAAEkKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKK 1406
SPRY_SOCS3 cd12876
SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family; The SPRY ...
 386-448 2.74e-05

SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family; The SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. All four SPSB proteins interact with c-Met, the hepatocyte growth factor receptor, but SOCS3 regulates cellular response to a variety of cytokines such as leukemia inhibitory factor (LIF) and interleukin 6. SOCS3, along with SOCS1, are expressed by immune cells and cells of the central nervous system (CNS) and have the potential to impact immune processes within the CNS. In non-small cell lung cancer (NSCLC), SOCS3 is silenced and proline-rich tyrosine kinase 2 (Pyk2) is over-expressed; it has been suggested that SOCS3 could be an effective way to prevent the progression of NSCLC due to its role in regulating Pyk2 expression.


Pssm-ID: 293936  Cd Length: 185  Bit Score: 46.38  E-value: 2.74e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281363687  386 LLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDD-VIGCYLDLESepCTINYTLNGEDLGVAFE 448
Cdd:cd12876    82 LLGEDEESWGLSYKGLLWHDGQSRPYTSPFGNQGtIIGVHLDMWR--GTLTFYKNGKPLGVAFT 143
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 516-652 3.06e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 47.88  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  516 KVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEA-AKPESEA-----TEASETA 589
Cdd:PRK09510  140 KAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAkKKAEAEAkkkaaAEAKKKA 219

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281363687  590 ETSTEKSSETAAvSNGDAAAEQANDEKASEDKKPSENNDEEDE---DGPSPNKRPKTDGDSEKAES 652
Cdd:PRK09510  220 AAEAKAAAAKAA-AEAKAAAEKAAAAKAAEKAAAAKAAAEVDDlfgGLDSGKNAPKTGGGAKGNGA 284
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 708-887 4.75e-05

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 45.49  E-value: 4.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  708 EVILLVGLPGAGKT----HWAHKHVAENADKRyeLIGPDAFiskmtidgaSRKTVHKGRWDKVY-EICLNSLAALEDIAM 782
Cdd:COG4088     5 MLLILTGPPGSGKTtfakALAQRLYAEGIAVA--LLHSDDF---------RRFLVNESFPKETYeEVVEDVRTTTADNAL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  783 KRRRNFILDQTNVYASAQRRKMKGFNDFKRIAVV-CIPSEDELKRRIAEKEEKgnaftVKESTINNLRANFTLP-SLEFG 860
Cdd:COG4088    74 DNGYSVIVDGTFYYRSWQRDFRNLAKHKAPIHIIyLKAPLETALRRNRERGEP-----IPERVIARMYRKFDKPgTKDRP 148

                         170       180
                  ....*....|....*....|....*..
gi 281363687  861 WFdDINYTELTGDEAKSEVKKYNEKGK 887
Cdd:COG4088   149 DL-VIDTTEDSVSETLDAILKAIETWG 174
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 539-667 5.04e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 47.68  E-value: 5.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   539 SEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQAnDEKAS 618
Cdd:TIGR00927  631 SKGDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEA-DHKGE 709

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 281363687   619 EDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYE 667
Cdd:TIGR00927  710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETE 758
PTZ00121 PTZ00121
MAEBL; Provisional
 526-664 5.82e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 5.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  526 DEVEKKDEDGKASSEKDEEEAEdpEKAKEDEAAPKTET-----EAETKVEAPAEAAKPESEATEASEtAETSTEKSSETA 600
Cdd:PTZ00121 1394 DEAKKKAEEDKKKADELKKAAA--AKKKADEAKKKAEEkkkadEAKKKAEEAKKADEAKKKAEEAKK-AEEAKKKAEEAK 1470

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281363687  601 AVSNGDAAAEQAndEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTED 664
Cdd:PTZ00121 1471 KADEAKKKAEEA--KKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEE 1532
PTZ00121 PTZ00121
MAEBL; Provisional
 519-674 1.25e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.67  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  519 DEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAApktetEAETKVEAPAEAAKPESEATEASETAETSTEKSSE 598
Cdd:PTZ00121 1616 EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKA-----EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKA 1690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  599 TAAVSNGDAAAEQAND--EKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEK------EKDRSQTTEDEYEDVV 670
Cdd:PTZ00121 1691 AEALKKEAEEAKKAEElkKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEakkdeeEKKKIAHLKKEEEKKA 1770


                  ....
gi 281363687  671 PEPR 674
Cdd:PTZ00121 1771 EEIR 1774
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 532-682 2.01e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 45.35  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  532 DEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASE-TAETSTEK--SSETAAVSngdAA 608
Cdd:PRK13108  309 ASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEeTSEADIEReqPGDLAGQA---PA 385

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281363687  609 AEQANDEKASEDKKPSENNDEEDEDGpspnkrpktdgdSEKAESEKEKDRSQTTEDEyEDVVPEPRDTAALLEG 682
Cdd:PRK13108  386 AHQVDAEAASAAPEEPAALASEAHDE------------TEPEVPEKAAPIPDPAKPD-ELAVAGPGDDPAEPDG 446
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 525-665 2.58e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 45.37  E-value: 2.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   525 DDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSN 604
Cdd:TIGR00927  709 ETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGED 788

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281363687   605 GDAAAEQAnDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESE-KEKDRSQTTEDE 665
Cdd:TIGR00927  789 GEMKGDEG-AEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQElNAENQGEAKQDE 849
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 523-681 3.52e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 45.10  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  523 ADDDEVEKKDEDGKASSEkdeeeaedpekakedEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAV 602
Cdd:PRK14949  624 SDLDALSPKEGDGKKSSA---------------DRKPKTPPSRAPPASLSKPASSPDASQTSASFDLDPDFELATHQSVP 688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  603 SNGDAAAEQANDEKAS--EDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQ----TTEDEYEDVVPEPRDT 676
Cdd:PRK14949  689 EAALASGSAPAPPPVPdpYDRPPWEEAPEVASANDGPNNAAEGNLSESVEDASNSELQAVeqqaTHQPQVQAEAQSPAST 768


                  ....*
gi 281363687  677 AALLE 681
Cdd:PRK14949  769 TALTQ 773
PRK13914 PRK13914
invasion associated endopeptidase;
533-654 3.59e-04

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 44.79  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  533 EDGKASSEKDEEEAEDPekAKEDEAAP----------------KTETEAETKVEAPAEAAKPeSEATEASETAETSTEKS 596
Cdd:PRK13914  245 QTANTATPKAEVKTEAP--AAEKQAAPvvkentntntattekkETTTQQQTAPKAPTEAAKP-APAPSTNTNANKTNTNT 321

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 281363687  597 SETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDedgpSPNKRPKTDGDSEKAESEK 654
Cdd:PRK13914  322 NTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQG----SSNNNSNSSASAIIAEAQK 375
rne PRK10811
ribonuclease E; Reviewed
 56-247 4.84e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 44.65  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   56 RRQRRTRSMSRSPSPVQAA---------------PVAaePVLDTLEEEEQPEDKTVPQPEPESEQPAAEPEPEQSEPEEA 120
Cdd:PRK10811  812 RRYRDERYPTQSPMPLTVAcaspemasgkvwiryPVV--RPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVE 889

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  121 EPaaavtEDTTVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPMEEdhdaapeeqeptqTEEPVEE 200
Cdd:PRK10811  890 AV-----AEVVEEPVVVAEPQPEEVVVVETTHPEVIAAPVTEQPQVITESDVAVAQEVAE-------------HAEPVVE 951

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 281363687  201 KPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEPAAKPEDQPPE 247
Cdd:PRK10811  952 PQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVE 998
PHA03169 PHA03169
hypothetical protein; Provisional
 519-641 6.71e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 43.81  E-value: 6.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  519 DEATADDDEVEKKDEDGKASSEKDEEEAE-DPEKAKEDEAAPKTETEAEtKVEAPAEAAKPESEATEASETAETSTEKSS 597
Cdd:PHA03169  128 PESPASHSPPPSPPSHPGPHEPAPPESHNpSPNQQPSSFLQPSHEDSPE-EPEPPTSEPEPDSPGPPQSETPTSSPPPQS 206

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 281363687  598 EtaavsnGDAAAEQANDEkASEDKKPSENNDEEDEDGPSPNKRP 641
Cdd:PHA03169  207 P------PDEPGEPQSPT-PQQAPSPNTQQAVEHEDEPTEPERE 243
PTZ00121 PTZ00121
MAEBL; Provisional
 516-664 7.93e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 7.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  516 KVLDEATADDDEVEKKDEDGKASSEKdEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASET--AETST 593
Cdd:PTZ00121 1398 KKAEEDKKKADELKKAAAAKKKADEA-KKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAkkADEAK 1476

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281363687  594 EKSSETAAVSNGDAAAEQANdEKASEDKKPSENNDEEDEDGPSPNKRpKTDgDSEKAESEKEKDRSQTTED 664
Cdd:PTZ00121 1477 KKAEEAKKADEAKKKAEEAK-KKADEAKKAAEAKKKADEAKKAEEAK-KAD-EAKKAEEAKKADEAKKAEE 1544
PHA03169 PHA03169
hypothetical protein; Provisional
 519-690 9.16e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 43.42  E-value: 9.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  519 DEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEA--SETAETSTEKS 596
Cdd:PHA03169   78 ESRHGEKEERGQGGPSGSGSESVGSPTPSPSGSAEELASGLSPENTSGSSPESPASHSPPPSPPSHPgpHEPAPPESHNP 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  597 SETAAVSNGDAAAEQANDEKA------SEDKKPSENNDEEDEDGPSPNKRPKTDGD-----SEKAESEKEKDRSQTTEDE 665
Cdd:PHA03169  158 SPNQQPSSFLQPSHEDSPEEPepptsePEPDSPGPPQSETPTSSPPPQSPPDEPGEpqsptPQQAPSPNTQQAVEHEDEP 237

                         170       180
                  ....*....|....*....|....*
gi 281363687  666 YEDVVPEPRDTAALLEGYVLIGLVP 690
Cdd:PHA03169  238 TEPEREGPPFPGHRSHSYTVVGWKP 262
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 529-667 9.99e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.45  E-value: 9.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   529 EKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAA 608
Cdd:TIGR00927  643 ERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETE 722

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 281363687   609 AEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDrSQTTEDEYE 667
Cdd:TIGR00927  723 AEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETE-AEGKEDEDE 780
PTZ00121 PTZ00121
MAEBL; Provisional
 527-669 1.03e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  527 EVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEA--PAEAAKPESE----ATEASETAETSTEKSSETA 600
Cdd:PTZ00121 1567 EEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEakKAEEAKIKAEelkkAEEEKKKVEQLKKKEAEEK 1646

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281363687  601 AVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDV 669
Cdd:PTZ00121 1647 KKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEK 1715
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 518-643 1.12e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 43.24  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  518 LDEATADDDEVEKKDEDgkassEKDEEEAEDPEKAKEDEAAPKTETEAETkveapAEAAKPESEATEaSETAETSTEKSS 597
Cdd:COG4547   207 LAEELGEDEDEEDEDDE-----DDSGEQEEDEEDGEDEDEESDEGAEAED-----AEASGDDAEEGE-SEAAEAESDEMA 275

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 281363687  598 ETAAVSNGDAAAEqandekasedkkPSENNDEEDEDGPSPNKRPKT 643
Cdd:COG4547   276 EEAEGEDSEEPGE------------PWRPNAPPPDDPADPDYKVFT 309
PTZ00121 PTZ00121
MAEBL; Provisional
 516-669 1.13e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  516 KVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEK 595
Cdd:PTZ00121 1497 KKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDK 1576

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  596 S-----------SETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTED 664
Cdd:PTZ00121 1577 NmalrkaeeakkAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE 1656


                  ....*
gi 281363687  665 EYEDV 669
Cdd:PTZ00121 1657 EENKI 1661
rpsP PRK14521
30S ribosomal protein S16; Provisional
 518-619 1.24e-03

30S ribosomal protein S16; Provisional


Pssm-ID: 237744 [Multi-domain]  Cd Length: 186  Bit Score: 41.30  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  518 LDEATADD--DEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPK-TETEAETKVEAPAEAAKPESEATEASETAETSTE 594
Cdd:PRK14521   94 FTEAQAEAkfEAWKEEKEGKVNAKKDKLSKAKKAAKKAALEAEKKvNEARAEAVAEKKAAEAAAVAAEEAAAAEEEEAEE 173

                          90       100
                  ....*....|....*....|....*
gi 281363687  595 kssetaavsngdAAAEQANDEKASE 619
Cdd:PRK14521  174 ------------APAEEAPAEESAE 186
PTZ00121 PTZ00121
MAEBL; Provisional
 516-665 1.38e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  516 KVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKED----EAAPKTETEAETKVEAPAEAAKPESEATEASETAET 591
Cdd:PTZ00121 1634 KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDkkkaEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAE 1713

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281363687  592 STEKSSET-AAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDgpspNKRPKTDGDSEKAESEKEKDRSQTTEDE 665
Cdd:PTZ00121 1714 EKKKAEELkKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEK----KKIAHLKKEEEKKAEEIRKEKEAVIEEE 1784
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 518-673 1.42e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 42.77  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  518 LDEATADDDEVEKKDEDGKASSEKDEEEAedpeKAKEDEAAPKTETeAETKVEAPAEAAKP-ESEATEASETAETST--- 593
Cdd:PRK08691  361 LAAASCDANAVIENTELQSPSAQTAEKET----AAKKPQPRPEAET-AQTPVQTASAAAMPsEGKTAGPVSNQENNDvpp 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  594 -EKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPE 672
Cdd:PRK08691  436 wEDAPDEAQTAAGTAQTSAKSIQTASEAETPPENQVSKNKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAE 515


                  .
gi 281363687  673 P 673
Cdd:PRK08691  516 P 516
PTZ00121 PTZ00121
MAEBL; Provisional
 526-678 1.42e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  526 DEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKveaPAEAAKPESEATEASETAETSTEKSSETAAVSNG 605
Cdd:PTZ00121 1486 DEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAK---KAEEAKKADEAKKAEEKKKADELKKAEELKKAEE 1562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  606 DAAAEQANDE---------KASEDKKPSENNDEEDEDGPSPNKRPKTDgDSEKAESEKEKDRSQTTEDEYEDVVPEPRDT 676
Cdd:PTZ00121 1563 KKKAEEAKKAeedknmalrKAEEAKKAEEARIEEVMKLYEEEKKMKAE-EAKKAEEAKIKAEELKKAEEEKKKVEQLKKK 1641


                  ..
gi 281363687  677 AA 678
Cdd:PTZ00121 1642 EA 1643
PTZ00121 PTZ00121
MAEBL; Provisional
 516-664 1.45e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  516 KVLDEATADDDEVEKKDEDGKASSE--KDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASEtAETST 593
Cdd:PTZ00121 1411 KKAAAAKKKADEAKKKAEEKKKADEakKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKK-ADEAK 1489

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281363687  594 EKSSEtaAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRpKTDgDSEKAESEKEKDRSQTTED 664
Cdd:PTZ00121 1490 KKAEE--AKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAK-KAD-EAKKAEEKKKADELKKAEE 1556
PNK-3'Pase TIGR01663
polynucleotide 5'-kinase 3'-phosphatase; This model represents the metazoan 5 ...
 707-874 1.67e-03

polynucleotide 5'-kinase 3'-phosphatase; This model represents the metazoan 5'-polynucleotide-kinase-3'-phosphatase, PNKP, which is believed to be involved in repair of oxidative DNA damage. Removal of 3' phosphates is essential for the further processing of the break by DNA polymerases. The central phosphatase domain is a member of the IIIA subfamily (TIGR01662) of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. As is common in this superfamily, the enzyme is magnesium dependent. A difference between this enzyme and other HAD-superfamily phosphatases is in the third conserved catalytic motif which usually contains two conserved aspartate residues believed to be involved in binding the magnesium ion. Here, the second aspartate is replaced by a conserved arginine residue which may indicate an interaction with the phosphate backbone of the substrate. Very close relatives of this domain are also found separate from the N- and C-terminal domains seen here, as in the 3'-phosphatase found in plants. The larger family of these domains is described by TIGR01664. Outside of the phosphatase domain is a P-loop ATP-binding motif associated with the kinase activity. The entry for the mouse homolog appears to be missing a large piece of sequence corresponding to the first conserved catalytic motif of the phosphatase domain as well as the conserved threonine of the second motif. Either this is a sequencing artifact or this may represent a pseudo- or non-functional gene. Note that the EC number for the kinase function is: 2.7.1.78


Pssm-ID: 130724 [Multi-domain]  Cd Length: 526  Bit Score: 42.70  E-value: 1.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   707 CEVILLVGLPGAGKTHWAHKHVAENAdkrYELIGPDAFiskmtidgasrktvhkGRWDKVYEIClnslaaleDIAMKRRR 786
Cdd:TIGR01663  369 CEMVIAVGFPGAGKSHFCKKFFQPAG---YKHVNADTL----------------GSTQNCLTAC--------ERALDQGK 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   787 NFILDQTNVYASAQRRKMKGFNDFK---RIAVVCIPSEdELKRRIAEKEEKGNAFT-VKESTINNLRANFTLPSLEFGWF 862
Cdd:TIGR01663  422 RCAIDNTNPDAASRAKFLQCARAAGipcRCFLFNAPLA-QAKHNIAFRELSDSAHIkIKDMVFNGMKKKFEAPALAEGFI 500

                          170
                   ....*....|....
gi 281363687   863 D--DINYTELTGDE 874
Cdd:TIGR01663  501 AihEINFKPLFADE 514
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 519-678 1.80e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 42.69  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  519 DEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSE 598
Cdd:COG5271   523 DAAADPEDSDEDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAETEDATENADADETEESADESEEAEASED 602

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  599 TAAV---SNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEkAESEKEKDRSQTTEDEYEDVVPEPRD 675
Cdd:COG5271   603 EAAEeeeADDDEADADADGAADEEETEEEAAEDEAAEPETDASEAADEDADAE-TEAEASADESEEEAEDESETSSEDAE 681


                  ...
gi 281363687  676 TAA 678
Cdd:COG5271   682 EDA 684
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
709-836 2.44e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 40.28  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  709 VILLVGLPGAGKTHWAhKHVAEnaDKRYELIGPDAFISKMTIDGASRKTVHKGRWDKVYEIcLNSLAALediAMKRRRNF 788
Cdd:COG0645     1 LILVCGLPGSGKSTLA-RALAE--RLGAVRLRSDVVRKRLFGAGLAPLERSPEATARTYAR-LLALARE---LLAAGRSV 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 281363687  789 ILDQTnvYASAQRRKMkgfndFKRIA---------VVCIPSEDELKRRIAEKEEKGN 836
Cdd:COG0645    74 ILDAT--FLRRAQREA-----FRALAeeagapfvlIWLDAPEEVLRERLEARNAEGG 123
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 476-668 2.76e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 42.20  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  476 SDTEQLLVNAERPTRKRRKPRKDEDKDKDDDKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKED 555
Cdd:NF033609  567 SDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDS 646

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  556 EAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGP 635
Cdd:NF033609  647 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 726

                         170       180       190
                  ....*....|....*....|....*....|...
gi 281363687  636 SPNKRPKTDGDSEKAESEKEKDRSQTTEDEYED 668
Cdd:NF033609  727 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 759
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
 516-663 3.30e-03

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 41.52  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  516 KVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEK 595
Cdd:PRK05901   61 GMVKDTDDATESDIPKKKTKTAAKAAAAKAPAKKKLKDELDSSKKAEKKNALDKDDDLNYVKDIDVLNQADDDDDDDDDD 140

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281363687  596 SSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTE 663
Cdd:PRK05901  141 DLDDDDIDDDDDDEDDDEDDDDDDVDDEDEEKKEAKELEKLSDDDDFVWDEDDSEALRQARKDAKLTA 208
PHA02664 PHA02664
hypothetical protein; Provisional
 529-659 4.08e-03

hypothetical protein; Provisional


Pssm-ID: 177447  Cd Length: 534  Bit Score: 41.14  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  529 EKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVE------APAEAAKPESEATEASETAETSTEKSSETAAV 602
Cdd:PHA02664  395 ERAANGARGSPMAAPEEGRAAAAAAAANAPADQDVEAEAHDEfdqdpgAPAHADRADSDEDDMDEQESGDERADGEDDSD 474

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 281363687  603 SNGDAAAEQANDEKASEDKKPSENNDE--EDEDGpspnkrpktdGDSEKAESEKEKDRS 659
Cdd:PHA02664  475 SSYSYSTTSSEDESDSADDSWGDESDSgiEHDDG----------GVGQAIEEEEEEERA 523
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 527-609 4.25e-03

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 39.81  E-value: 4.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687   527 EVEKKDEDGKASSEKDE---EEAEdPEKAKEDEAAPKTETEAETKVEAPAEAAK---------PESEATEAS--ETAETS 592
Cdd:pfam14962   95 EKENVAEAEKASSEAPEvsvVEAE-VVDAEEIPDATAAVIEEASACPGDVEAAPvettavgaeTGPEVTDAAtgETTEVS 173

                           90
                   ....*....|....*..
gi 281363687   593 TEKSSETAAVSNGDAAA 609
Cdd:pfam14962  174 AETTPEVTSAAPDEAVA 190
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 524-632 4.33e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 41.70  E-value: 4.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  524 DDDEVEKKDEDGKASSEKD-EEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEateasETAETSTEKSSETAAV 602
Cdd:PTZ00341 1038 DEENVEEIEENAEENVEENiEENIEEYDEENVEEIEENIEENIEENVEENVEENVEEIE-----ENVEENVEENAEENAE 1112

                          90       100       110
                  ....*....|....*....|....*....|
gi 281363687  603 SNGDAAAEQANDEkasedkKPSENNDEEDE 632
Cdd:PTZ00341 1113 ENAEENAEEYDDE------NPEEHNEEYDE 1136
PTZ00121 PTZ00121
MAEBL; Provisional
 516-668 4.62e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 4.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  516 KVLDEATADDDEVEKKDEDGKASSEKDEEE-----AEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAE 590
Cdd:PTZ00121 1418 KKADEAKKKAEEKKKADEAKKKAEEAKKADeakkkAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKK 1497

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281363687  591 TSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYED 668
Cdd:PTZ00121 1498 KADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEED 1575
PTZ00121 PTZ00121
MAEBL; Provisional
 520-678 4.73e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  520 EATADDDEVEKKDEDGK-ASSEKDEEE--------------------AEDPEKAKE----------DEAAPKTETEAETK 568
Cdd:PTZ00121 1227 EAVKKAEEAKKDAEEAKkAEEERNNEEirkfeearmahfarrqaaikAEEARKADElkkaeekkkaDEAKKAEEKKKADE 1306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  569 VEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRpKTDGDSE 648
Cdd:PTZ00121 1307 AKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKK-KADAAKK 1385

                         170       180       190
                  ....*....|....*....|....*....|
gi 281363687  649 KAESEKEKDRSQTTEDEYEDVVPEPRDTAA 678
Cdd:PTZ00121 1386 KAEEKKKADEAKKKAEEDKKKADELKKAAA 1415
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 1036-1108 6.98e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 40.67  E-value: 6.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  1036 GYDDRGYGSSRDY-------RDRDRGNDRSRMGSNDRNRGSSQSSYRsgggtHQQRD-FRPGHRDTKEDSRGGYERSAGQ 1107
Cdd:TIGR01622    1 RYRDRERERLRDSssagdrdRRRDKGRERSRDRSRDRERSRSRRRDR-----HRDRDyYRGRERRSRSRRPNRRYRPREK 75


                   .
gi 281363687  1108 S 1108
Cdd:TIGR01622   76 R 76
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 526-599 7.57e-03

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 40.44  E-value: 7.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281363687  526 DEVEKKDEdgKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSET 599
Cdd:PTZ00144  119 DTGGAPPA--AAPAAAAAAKAEKTTPEKPKAAAPTPEPPAASKPTPPAAAKPPEPAPAAKPPPTPVARADPRET 190
SPRY1_RyR cd12877
SPRY domain 1 (SPRY1) of ryanodine receptor (RyR); This SPRY domain is the first of three ...
 349-462 7.59e-03

SPRY domain 1 (SPRY1) of ryanodine receptor (RyR); This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this first SPRY domain of the RyRs.


Pssm-ID: 240457  Cd Length: 151  Bit Score: 38.45  E-value: 7.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  349 FEVRLseESVPENSHyfrDEPHvrgFRVGFSM-----------PKS-SLLLGEAEHSFGY----CETGRKATQSefTDYG 412
Cdd:cd12877    22 FEVEV--DHVEQFTH---QPAH---LRVGWANtsgyvpypgggEGWgGNGVGDDLYSYGFdglhLWTGGRSRRV--TSGT 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281363687  413 KPY-QLDDVIGCYLDLeSEPCtINYTLNGEDlgVAFEFEKSILgeEGALFP 462
Cdd:cd12877    92 QHLlKKGDVVGCCLDL-SVPS-ISFRVNGRP--VQGMFENFNL--DGMFFP 136
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
 516-678 7.91e-03

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 40.36  E-value: 7.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  516 KVLDEATADDDEVEKKDEDGKASSEKDEEEAEDpEKAKEDEAAPKTETEAETkveapAEAAKPESEATEASETAETSTEK 595
Cdd:PRK05901   60 SGMVKDTDDATESDIPKKKTKTAAKAAAAKAPA-KKKLKDELDSSKKAEKKN-----ALDKDDDLNYVKDIDVLNQADDD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  596 SSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPspnkrpktdgDSEKAESEKEKDRSQTTEDEYEDVVPEPRD 675
Cdd:PRK05901  134 DDDDDDDDLDDDDIDDDDDDEDDDEDDDDDDVDDEDEEKK----------EAKELEKLSDDDDFVWDEDDSEALRQARKD 203


                  ...
gi 281363687  676 TAA 678
Cdd:PRK05901  204 AKL 206
HSP90 pfam00183
Hsp90 protein;
527-570 8.21e-03

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 40.23  E-value: 8.21e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 281363687   527 EVEKKDEDGKASSEKDEEEAEDP--EKAKEDEAAPKTETEAETKVE 570
Cdd:pfam00183   32 EVEVPDEEEEEEEEEEEEEDDDPkvEEEDEEEEKKKTKKVKETVWE 77
COG5137 COG5137
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics] ...
 526-648 8.53e-03

Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics];


Pssm-ID: 227466 [Multi-domain]  Cd Length: 279  Bit Score: 39.59  E-value: 8.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363687  526 DEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETaaVSNG 605
Cdd:COG5137   159 DNDEDNDEAPPAQPDVDNEEEERLEESDGREEEEDEEVGSDSYGEGNRELNEEEEEEAEGSDDGEDVVDYEGER--IDKK 236

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 281363687  606 DAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSE 648
Cdd:COG5137   237 QGEEEEMEEEVINLFEIEWEEESPSEEVPRNNEESPAKKQKVE 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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