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Conserved domains on  [gi|281365617|ref|NP_001163343|]
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uncharacterized protein Dmel_CG14995, isoform G [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-131 1.94e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 1.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617  44 EVLALSVNKISTLSTFEDCTKLQELYLRKNSISDINEIA-YLQNLPSLRNLWLEENPCCerAGPNYRSIVLRALPNLKKL 122
Cdd:cd21340  123 RVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSLEVL 200


                 ....*....
gi 281365617 123 DNVEVTQQE 131
Cdd:cd21340  201 DGKEITDTE 209
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-131 1.94e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 1.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617  44 EVLALSVNKISTLSTFEDCTKLQELYLRKNSISDINEIA-YLQNLPSLRNLWLEENPCCerAGPNYRSIVLRALPNLKKL 122
Cdd:cd21340  123 RVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSLEVL 200


                 ....*....
gi 281365617 123 DNVEVTQQE 131
Cdd:cd21340  201 DGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-126 3.30e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 3.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617  16 SDLSLIKKLNCWGSDLSDVSI-IKRMRGVEVLALSVNKISTLS-TFEDCTKLQELYLRKNSISDINEIayLQNLPSLRNL 93
Cdd:COG4886  156 GNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETL 233

                         90       100       110
                 ....*....|....*....|....*....|...
gi 281365617  94 WLEENPcceragpnyrsivLRALPNLKKLDNVE 126
Cdd:COG4886  234 DLSNNQ-------------LTDLPELGNLTNLE 253
LRR_9 pfam14580
Leucine-rich repeat;
30-135 1.80e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 50.53  E-value: 1.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617   30 DLSDVSIIK-----RMRGVEVLALSVNKISTLSTF--EDCTKLQELYLRKNSISDINEIAYLQNLPSLRNLWLEENPCCE 102
Cdd:pfam14580  48 DFSDNEIRKldgfpLLRRLKTLLLNNNRICRIGEGlgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTN 127

                          90       100       110
                  ....*....|....*....|....*....|...
gi 281365617  103 RagPNYRSIVLRALPNLKKLDNVEVTQQEVEDA 135
Cdd:pfam14580 128 K--PHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-131 1.94e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 1.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617  44 EVLALSVNKISTLSTFEDCTKLQELYLRKNSISDINEIA-YLQNLPSLRNLWLEENPCCerAGPNYRSIVLRALPNLKKL 122
Cdd:cd21340  123 RVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSLEVL 200


                 ....*....
gi 281365617 123 DNVEVTQQE 131
Cdd:cd21340  201 DGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-126 3.30e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 3.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617  16 SDLSLIKKLNCWGSDLSDVSI-IKRMRGVEVLALSVNKISTLS-TFEDCTKLQELYLRKNSISDINEIayLQNLPSLRNL 93
Cdd:COG4886  156 GNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETL 233

                         90       100       110
                 ....*....|....*....|....*....|...
gi 281365617  94 WLEENPcceragpnyrsivLRALPNLKKLDNVE 126
Cdd:COG4886  234 DLSNNQ-------------LTDLPELGNLTNLE 253
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-123 5.05e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 5.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617  16 SDLSLIKKLNCWGSDLSDV-SIIKRMRGVEVLALSVNKISTL-STFEDCTKLQELYLRKNSISDINEIayLQNLPSLRNL 93
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKEL 187

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 281365617  94 WLEENPcceragpnyrsI-----VLRALPNLKKLD 123
Cdd:COG4886  188 DLSNNQ-----------ItdlpePLGNLTNLEELD 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-99 7.45e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 7.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617  16 SDLSLIKKLNCWGSDLSDVSI-IKRMRGVEVLALSVNKISTLSTFEDCTKLQELYLRKNSISDINEIAylqNLPSLRNLW 94
Cdd:COG4886  202 GNLTNLEELDLSGNQLTDLPEpLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA---NLTNLKTLD 278


                 ....*
gi 281365617  95 LEENP 99
Cdd:COG4886  279 LSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-136 7.66e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 7.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617  16 SDLSLIKKLNCWGSDLSDVSIIKRMRGVEVLALSVNKISTLSTFEDCTKLQELYLRKNSISDIN--EIAYLQNLPSLRNL 93
Cdd:COG4886  225 ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlkELELLLGLNSLLLL 304

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 281365617  94 WLEENPCCERAGPNYRSIVLRALPNLKKLDNVEVTQQEVEDAL 136
Cdd:COG4886  305 LLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
LRR_9 pfam14580
Leucine-rich repeat;
30-135 1.80e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 50.53  E-value: 1.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617   30 DLSDVSIIK-----RMRGVEVLALSVNKISTLSTF--EDCTKLQELYLRKNSISDINEIAYLQNLPSLRNLWLEENPCCE 102
Cdd:pfam14580  48 DFSDNEIRKldgfpLLRRLKTLLLNNNRICRIGEGlgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTN 127

                          90       100       110
                  ....*....|....*....|....*....|...
gi 281365617  103 RagPNYRSIVLRALPNLKKLDNVEVTQQEVEDA 135
Cdd:pfam14580 128 K--PHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR_8 pfam13855
Leucine rich repeat;
41-99 3.01e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 3.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281365617   41 RGVEVLALSVNKISTL--STFEDCTKLQELYLRKNSISDINEIAyLQNLPSLRNLWLEENP 99
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
18-123 2.85e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 2.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365617  18 LSLIKKLNCWGSDLSDVSIIKRMRGVEVLALSVNKistlsTFEDCTKLQELYLRKNSISDINEiaYLQNLPSLRNLWLEE 97
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSN 145

                         90       100
                 ....*....|....*....|....*...
gi 281365617  98 NpcceragpNYRSI--VLRALPNLKKLD 123
Cdd:COG4886  146 N--------QLTDLpePLGNLTNLKSLD 165
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 24-98 2.92e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 2.92e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281365617  24 LNCWGSDLSDVSIIKRMRGVEVLALSVNKISTLSTFEDCTKLQELYLRKNSISdinEIAYLQNLPSLRNLWLEEN 98
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIE---KIENLENLVNLKKLYLGGN 78
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 63-99 5.80e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 5.80e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 281365617   63 TKLQELYLRKNSISDINEiayLQNLPSLRNLWLEENP 99
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP---LAKLPNLETLDLSGNN 34
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 43-82 1.43e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 1.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 281365617   43 VEVLALSVNKISTLSTFEDCTKLQELYLRKNS-ISDINEIA 82
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
22-75 9.39e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 281365617   22 KKLNCWGSDLSDV--SIIKRMRGVEVLALSVNKISTLS--TFEDCTKLQELYLRKNSI 75
Cdd:pfam13855   4 RSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSpgAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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