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Conserved domains on  [gi|281365853|ref|NP_001163381|]
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uncharacterized protein Dmel_CG6282, isoform C [Drosophila melanogaster]

Protein Classification

DUF1295 domain-containing protein( domain architecture ID 10536620)

DUF1295 domain-containing protein similar to Arabidopsis thaliana 3-oxo-5-alpha-steroid 4-dehydrogenase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF1295 pfam06966
Protein of unknown function (DUF1295); This family contains a number of bacterial and ...
25-264 6.05e-104

Protein of unknown function (DUF1295); This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long.


:

Pssm-ID: 399743  Cd Length: 235  Bit Score: 303.52  E-value: 6.05e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853   25 FFLINSVLQMDKLTDFAGGVNFIIISLLTFFLgqidrpSKAYDSRQLMVTLFVCLWGARLSGYLLYRIVKLGRDKQFEDT 104
Cdd:pfam06966   1 FWAISRRTGNYSLVDVAWGGGFVLLAVLTLLL------SEGATLRRMLVTVLVTLWGARLAWHLLRRNWGWGEDYRYVDL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853  105 RRNI------IRYAVFWTFQAVWVYIVSLPVIIINSPRHSQPrapktMTTLDSTGTGMFIVGLLAETYADLQKFSFRQDP 178
Cdd:pfam06966  75 RKNWgktpylLRLLIFFILQAVLLYIVSLPVYLANASGNNPA-----FGAWDIIGIAVWLVGFLFEALADQQLWAFKADP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853  179 ANQGKFCNDGLWSVSRHPNYFGEVVIWWGIFAISLNVISGHEWVAIASPIFTTMIILFLSGIPLRERSADEKYKDQLEYR 258
Cdd:pfam06966 150 ANRGKFCDTGLWRYSRHPNYFGEALIWWGIFLIALNVLSGLEWWTIFGPLVMTLLLVFVSGIPLTERSADKKYGDREDYR 229

                  ....*.
gi 281365853  259 KYKAST 264
Cdd:pfam06966 230 AYQRTT 235
 
Name Accession Description Interval E-value
DUF1295 pfam06966
Protein of unknown function (DUF1295); This family contains a number of bacterial and ...
25-264 6.05e-104

Protein of unknown function (DUF1295); This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long.


Pssm-ID: 399743  Cd Length: 235  Bit Score: 303.52  E-value: 6.05e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853   25 FFLINSVLQMDKLTDFAGGVNFIIISLLTFFLgqidrpSKAYDSRQLMVTLFVCLWGARLSGYLLYRIVKLGRDKQFEDT 104
Cdd:pfam06966   1 FWAISRRTGNYSLVDVAWGGGFVLLAVLTLLL------SEGATLRRMLVTVLVTLWGARLAWHLLRRNWGWGEDYRYVDL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853  105 RRNI------IRYAVFWTFQAVWVYIVSLPVIIINSPRHSQPrapktMTTLDSTGTGMFIVGLLAETYADLQKFSFRQDP 178
Cdd:pfam06966  75 RKNWgktpylLRLLIFFILQAVLLYIVSLPVYLANASGNNPA-----FGAWDIIGIAVWLVGFLFEALADQQLWAFKADP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853  179 ANQGKFCNDGLWSVSRHPNYFGEVVIWWGIFAISLNVISGHEWVAIASPIFTTMIILFLSGIPLRERSADEKYKDQLEYR 258
Cdd:pfam06966 150 ANRGKFCDTGLWRYSRHPNYFGEALIWWGIFLIALNVLSGLEWWTIFGPLVMTLLLVFVSGIPLTERSADKKYGDREDYR 229

                  ....*.
gi 281365853  259 KYKAST 264
Cdd:pfam06966 230 AYQRTT 235
COG3752 COG3752
Steroid 5-alpha reductase family enzyme [General function prediction only];
11-272 4.28e-68

Steroid 5-alpha reductase family enzyme [General function prediction only];


Pssm-ID: 442966  Cd Length: 264  Bit Score: 213.16  E-value: 4.28e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853  11 FAISAIVVGSLQLVFFLINSVLQMDKLTDFAGGVNFIIISLLTFFLGQidrpskAYDSRQLMVTLFVCLWGARLSGYLLY 90
Cdd:COG3752    9 LLLALAALLAVMLLAWLVSLRTRNASIVDVAWSLGFVLVALVYALLGD------GDDARRLLVAALVTLWGLRLGGHLAR 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853  91 RIVKLGRDKQFEDTRRN------IIRYAVFWTFQAVWVYIVSLPVIIINsprHSQPRAPktMTTLDSTGTGMFIVGLLAE 164
Cdd:COG3752   83 RNRGKGEDPRYAALRERwgrgfaLFSLFFVFLLQALLVWLVSLPVLAAA---ASPAPAP--LGWLDVLGAALWLVGFAFE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853 165 TYADLQKFSFRQDPANQGKFCNDGLWSVSRHPNYFGEVVIWWGIFAISLNVISGheWVAIASPIFTTMIILFLSGIPLRE 244
Cdd:COG3752  158 AVADAQLARFKADPANKGKVCDTGLWRYSRHPNYFGEWLVWWGLALFALAAPPG--WWTLIGPLLMTLLLLKVSGIPLLE 235
                        250       260
                 ....*....|....*....|....*...
gi 281365853 245 RSADEKYKDqleYRKYKASTSPLIPVPP 272
Cdd:COG3752  236 KHMLESRPA---YREYQRRTSAFFPWPP 260
 
Name Accession Description Interval E-value
DUF1295 pfam06966
Protein of unknown function (DUF1295); This family contains a number of bacterial and ...
25-264 6.05e-104

Protein of unknown function (DUF1295); This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long.


Pssm-ID: 399743  Cd Length: 235  Bit Score: 303.52  E-value: 6.05e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853   25 FFLINSVLQMDKLTDFAGGVNFIIISLLTFFLgqidrpSKAYDSRQLMVTLFVCLWGARLSGYLLYRIVKLGRDKQFEDT 104
Cdd:pfam06966   1 FWAISRRTGNYSLVDVAWGGGFVLLAVLTLLL------SEGATLRRMLVTVLVTLWGARLAWHLLRRNWGWGEDYRYVDL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853  105 RRNI------IRYAVFWTFQAVWVYIVSLPVIIINSPRHSQPrapktMTTLDSTGTGMFIVGLLAETYADLQKFSFRQDP 178
Cdd:pfam06966  75 RKNWgktpylLRLLIFFILQAVLLYIVSLPVYLANASGNNPA-----FGAWDIIGIAVWLVGFLFEALADQQLWAFKADP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853  179 ANQGKFCNDGLWSVSRHPNYFGEVVIWWGIFAISLNVISGHEWVAIASPIFTTMIILFLSGIPLRERSADEKYKDQLEYR 258
Cdd:pfam06966 150 ANRGKFCDTGLWRYSRHPNYFGEALIWWGIFLIALNVLSGLEWWTIFGPLVMTLLLVFVSGIPLTERSADKKYGDREDYR 229

                  ....*.
gi 281365853  259 KYKAST 264
Cdd:pfam06966 230 AYQRTT 235
COG3752 COG3752
Steroid 5-alpha reductase family enzyme [General function prediction only];
11-272 4.28e-68

Steroid 5-alpha reductase family enzyme [General function prediction only];


Pssm-ID: 442966  Cd Length: 264  Bit Score: 213.16  E-value: 4.28e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853  11 FAISAIVVGSLQLVFFLINSVLQMDKLTDFAGGVNFIIISLLTFFLGQidrpskAYDSRQLMVTLFVCLWGARLSGYLLY 90
Cdd:COG3752    9 LLLALAALLAVMLLAWLVSLRTRNASIVDVAWSLGFVLVALVYALLGD------GDDARRLLVAALVTLWGLRLGGHLAR 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853  91 RIVKLGRDKQFEDTRRN------IIRYAVFWTFQAVWVYIVSLPVIIINsprHSQPRAPktMTTLDSTGTGMFIVGLLAE 164
Cdd:COG3752   83 RNRGKGEDPRYAALRERwgrgfaLFSLFFVFLLQALLVWLVSLPVLAAA---ASPAPAP--LGWLDVLGAALWLVGFAFE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853 165 TYADLQKFSFRQDPANQGKFCNDGLWSVSRHPNYFGEVVIWWGIFAISLNVISGheWVAIASPIFTTMIILFLSGIPLRE 244
Cdd:COG3752  158 AVADAQLARFKADPANKGKVCDTGLWRYSRHPNYFGEWLVWWGLALFALAAPPG--WWTLIGPLLMTLLLLKVSGIPLLE 235
                        250       260
                 ....*....|....*....|....*...
gi 281365853 245 RSADEKYKDqleYRKYKASTSPLIPVPP 272
Cdd:COG3752  236 KHMLESRPA---YREYQRRTSAFFPWPP 260
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
153-269 1.06e-09

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 55.17  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365853 153 GTGMFIVGLLAETYADL---QKFSFRQDPANQGKFCNDGLWSVSRHPNYFGEVVIWWGIFAISLNVisgheWVAIASPIF 229
Cdd:COG2020    2 GLVLILLGLLLRLWAVLtlgRSWTTLVPPRKAHRLVTTGPYRYVRHPMYLGFLLLLLGLALLLGSL-----LALLLALLL 76
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 281365853 230 TTMIILflsGIPLRERSADEKYKDqlEYRKYKASTSPLIP 269
Cdd:COG2020   77 LLLYVL---RIRREERRLRARFGE--EYRAYAARVPRLIP 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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