NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|281361508|ref|NP_001163579|]
View 

uncharacterized protein Dmel_CG5359, isoform B [Drosophila melanogaster]

Protein Classification

Tctex-type family dynein light chain( domain architecture ID 16901542)

Tctex-type family dynein light chain such as dynein light chain Tctex-type protein 2B, which acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system

CATH:  3.30.1140.40
Gene Ontology:  GO:0007018|GO:0045505|GO:0005868
PubMed:  11278908|36861883
SCOP:  3000821

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DLC-like_TCTEX1D2 cd21459
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) ...
 69-171 4.11e-43

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) and similar proteins; Tctex1 domain-containing protein 2 (TCTEX1D2) is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D2.


:

Pssm-ID: 412007  Cd Length: 104  Bit Score: 138.77  E-value: 4.11e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508  69 FPLPTIKSIMNNVMAEKLKDKTYDKDVAKKWTSEIADEVNQQIASSSLvKRYKHVVQVMLGQELGAGATYNSRCCWDCDC 148
Cdd:cd21459    2 FRPSKVKEIIHEVLKEKLAGKTYDPEEAPQWTKEIADEIKDKLKELGF-PRYKIVVQVVIGEQRGQGVRVGSRCLWDADT 80

                         90       100
                 ....*....|....*....|...
gi 281361508 149 DTSVSEVFSNTSLFCVCTVFGTY 171
Cdd:cd21459   81 DNYASEVFINDSLFCVATVFGVY 103
 
Name Accession Description Interval E-value
DLC-like_TCTEX1D2 cd21459
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) ...
 69-171 4.11e-43

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) and similar proteins; Tctex1 domain-containing protein 2 (TCTEX1D2) is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D2.


Pssm-ID: 412007  Cd Length: 104  Bit Score: 138.77  E-value: 4.11e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508  69 FPLPTIKSIMNNVMAEKLKDKTYDKDVAKKWTSEIADEVNQQIASSSLvKRYKHVVQVMLGQELGAGATYNSRCCWDCDC 148
Cdd:cd21459    2 FRPSKVKEIIHEVLKEKLAGKTYDPEEAPQWTKEIADEIKDKLKELGF-PRYKIVVQVVIGEQRGQGVRVGSRCLWDADT 80

                         90       100
                 ....*....|....*....|...
gi 281361508 149 DTSVSEVFSNTSLFCVCTVFGTY 171
Cdd:cd21459   81 DNYASEVFINDSLFCVATVFGVY 103
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 74-168 1.90e-34

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 116.47  E-value: 1.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508   74 IKSIMNNVMAEKLK-DKTYDKDVAKKWTSEIADEVNQQIASSSLvKRYKHVVQVMLGQELGAGATYNSRCCWDCDCDTSV 152
Cdd:pfam03645   2 VKEIIKEVLEEVLGgGETYDHEKVPQWTKEISEEILDRLKELGF-KRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYA 80

                          90
                  ....*....|....*.
gi 281361508  153 SEVFSNTSLFCVCTVF 168
Cdd:pfam03645  81 SYKFENKSLFAVVTVF 96
 
Name Accession Description Interval E-value
DLC-like_TCTEX1D2 cd21459
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) ...
 69-171 4.11e-43

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) and similar proteins; Tctex1 domain-containing protein 2 (TCTEX1D2) is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D2.


Pssm-ID: 412007  Cd Length: 104  Bit Score: 138.77  E-value: 4.11e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508  69 FPLPTIKSIMNNVMAEKLKDKTYDKDVAKKWTSEIADEVNQQIASSSLvKRYKHVVQVMLGQELGAGATYNSRCCWDCDC 148
Cdd:cd21459    2 FRPSKVKEIIHEVLKEKLAGKTYDPEEAPQWTKEIADEIKDKLKELGF-PRYKIVVQVVIGEQRGQGVRVGSRCLWDADT 80

                         90       100
                 ....*....|....*....|...
gi 281361508 149 DTSVSEVFSNTSLFCVCTVFGTY 171
Cdd:cd21459   81 DNYASEVFINDSLFCVATVFGVY 103
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 74-168 1.90e-34

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 116.47  E-value: 1.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508   74 IKSIMNNVMAEKLK-DKTYDKDVAKKWTSEIADEVNQQIASSSLvKRYKHVVQVMLGQELGAGATYNSRCCWDCDCDTSV 152
Cdd:pfam03645   2 VKEIIKEVLEEVLGgGETYDHEKVPQWTKEISEEILDRLKELGF-KRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYA 80

                          90
                  ....*....|....*.
gi 281361508  153 SEVFSNTSLFCVCTVF 168
Cdd:pfam03645  81 SYKFENKSLFAVVTVF 96
DLC-like_TCTEX1D cd21451
dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) ...
 69-170 5.38e-29

dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) family; The Tctex1 domain-containing protein (TCTEX1D) family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. TCTEX1D2 is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. TCTEX1D3, also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4, also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2, and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1Ds.


Pssm-ID: 411999  Cd Length: 101  Bit Score: 102.96  E-value: 5.38e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508  69 FPLPTIKSIMNNVMAEKLKDKTYDKDVAKKWTSEIADEVNQQIASSsLVKRYKHVVQVMLGQELGAGATYNSRCCWDCDC 148
Cdd:cd21451    1 FNPEKVKKIIKEVLEERLENVTYDPEECAQLCKELSEEIKDRVKEL-GFDRYKIVVQVTIGEKKGQGVRVASRCLWDPET 79

                         90       100
                 ....*....|....*....|..
gi 281361508 149 DTSVSEVFSNTSLFCVCTVFGT 170
Cdd:cd21451   80 DNFASATFENESLFAVATVFGV 101
DLC-like_TCTEX1D1 cd21458
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 1 (TCTEX1D1) ...
 69-171 3.26e-23

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 1 (TCTEX1D1) and similar proteins; Tctex1 domain-containing protein 1 (TCTEX1D1) is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. The model corresponds to the (dynein light chain) DLC-like domain of TCTEX1D1.


Pssm-ID: 412006  Cd Length: 104  Bit Score: 88.12  E-value: 3.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508  69 FPLPTIKSIMNNVMAEKLKDKTYDKDVAKKWTSEIADEVNQQIASSSLvKRYKHVVQVMLGQELGAGATYNSRCCWDCDC 148
Cdd:cd21458    1 FPVASVKNILKDVLESYLQEERYEPELCRQMTKTISEVIKARVKDLML-PRYKIIVLVHIGQLNDQGLRVGSRCLWDPAN 79

                         90       100
                 ....*....|....*....|...
gi 281361508 149 DTSVSEVFSNTSLFCVCTVFGTY 171
Cdd:cd21458   80 DTFSSYEFRNSSLFAVATVYGVY 102
DLC-like_SF cd21449
dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of ...
 74-169 4.30e-19

dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.


Pssm-ID: 411997  Cd Length: 96  Bit Score: 77.38  E-value: 4.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508  74 IKSIMNNVMAEKLKDKTYDKDVAKKWTSEIADEVNQQIASSSLvKRYKHVVQVMLGQELGAGATYNSRCCWDCDCDTSVS 153
Cdd:cd21449    2 IREIIKEVLESILDDKEYDPLKLKEIAKKISEEIKEKLKELSP-SRYKYIVHVTISENNGQGIRADSGCLWDPDTDGFVS 80

                         90
                 ....*....|....*.
gi 281361508 154 EVFSNTSLFCVCTVFG 169
Cdd:cd21449   81 EVYENDNIICTVTVFG 96
DLC-like_DYNLT1_DYNLT3 cd21455
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 74-169 2.85e-18

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) family; The dynein light chain Tctex-type 1 (DYNLT1) family includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1 and DYNLT3.


Pssm-ID: 412003  Cd Length: 97  Bit Score: 75.31  E-value: 2.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508  74 IKSIMNNVMAEKLKDKTYDKDVAKKWTSEIADEVNQQIASssLVKRYKHVVQVMLGQELGAGATYNSRCCWDCDCDTSVS 153
Cdd:cd21455    3 VESIVKEAIEAVLGDKTYSHSKVNQWSNSIVEEILKRLAK--LNKPFKYIVTCVIMQKTGAGLHTASSCYWDPTTDGSVT 80

                         90
                 ....*....|....*.
gi 281361508 154 EVFSNTSLFCVCTVFG 169
Cdd:cd21455   81 VRWENKTMYCIVTVFG 96
DLC-like_TCTEX1D4 cd21461
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) ...
 59-171 5.01e-17

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) and similar proteins; Tctex1 domain-containing protein 4 (TCTEX1D4), also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2 and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D4.


Pssm-ID: 412009  Cd Length: 114  Bit Score: 72.38  E-value: 5.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508  59 YSMRPAFGEMFPLPTIKSIMNNVMAEKLKDKTYDKDVAKKWTSEIADEVNQQIASSSLvKRYKHVVQVMLGQELGAGATY 138
Cdd:cd21461    1 YKTGPDPGCRFDASRVQQILEATLDSYLGGARYSPATCGQLSQGLSELVRSKVKDLSP-PRYKLVCQVVLGQCGNQGLRV 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 281361508 139 NSRCCWDCDCDTSVSEVFSNTSLFCVCTVFGTY 171
Cdd:cd21461   80 ASRCLWDPERDNFASASFQNASLFAVATVHGVY 112
DLC-like_TCTEX1D3 cd21460
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) ...
 59-171 1.04e-16

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) and similar proteins; Tctex1 domain-containing protein 3 (TCTEX1D3), also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D3.


Pssm-ID: 412008  Cd Length: 112  Bit Score: 71.59  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508  59 YSMRPAfgEMFPLPTIKSIMNNVMAEKLKDKTYDKDVAKKWTSEIADEVnqqiasSSLVK-----RYKHVVQVMLGQELG 133
Cdd:cd21460    3 YRLEPL--KKFQPHLVRKKAEEILKEKLKDIKYDADRCRSLSLSLAADI------LAAVKelgfdRYKYVVRVFLGEKTG 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 281361508 134 AGATYNSRCCWDCDCDTSVSEVFSNTSLFCVCTVFGTY 171
Cdd:cd21460   75 QSVKIASRAVWDTEKDNWVSATFENESLFAVALVFALY 112
DLC-like_DYNLT1 cd21462
dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and ...
 69-169 7.75e-09

dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins; Dynein light chain Tctex-type 1 (DYNLT1), also called TCTEL1, or TCTEX1, or protein CW-1, or T-complex testis-specific protein 1 homolog, is a non-catalytic accessory component of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It plays a role in neuronal morphogenesis. It is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1.


Pssm-ID: 412010  Cd Length: 102  Bit Score: 50.54  E-value: 7.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361508  69 FPLPTIKSIMNNVMAEKLKDKTYDKDVAKKWTSEIADEVNQQIasSSLVKRYKHVVQVMLGQELGAGATYNSRCCWDCDC 148
Cdd:cd21462    1 FVVDEVSNIIKEAIESTIGGNAYQHNKVNQWTSNVVEQCLNQL--TKLGKPFKYIVTCVIMQKNGAGLHTASSCFWDNST 78

                         90       100
                 ....*....|....*....|.
gi 281361508 149 DTSVSEVFSNTSLFCVCTVFG 169
Cdd:cd21462   79 DGSCTVRWENKTMYCIVSVFG 99
DLC-like_DYNLT3 cd21463
dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 3 (DYNLT3) and ...
 91-168 2.42e-05

dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 3 (DYNLT3) and similar proteins; Dynein light chain Tctex-type 3 (DYNLT3), also called rp3, or protein 91/23, or T-complex-associated testis-expressed 1-like, is a non-catalytic accessory component of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It has a potential role in chromosome congression in human mitosis and is required for chromosome alignment during mouse oocyte meiotic maturation. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT3.


Pssm-ID: 412011  Cd Length: 97  Bit Score: 41.42  E-value: 2.42e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281361508  91 YDKDVAKKWTSEIADEVNQQIASssLVKRYKHVVQVMLGQELGAGATYNSRCCWDCDCDTSVSEVFSNTSLFCVCTVF 168
Cdd:cd21463   20 YNHNKINQWTAAIVEQSLTHLVK--LGKPFKYIVTCAVMQKSGAGLHTASSCFWDTTTDGSCTVRWENRTMYCVVSVF 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH