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Conserved domains on  [gi|281362294|ref|NP_001163690|]
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octopamine beta1 receptor, isoform C [Drosophila melanogaster]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606756)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
109-415 1.99e-172

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


:

Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 483.03  E-value: 1.99e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15066    1 LKGFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKV 268
Cdd:cd15066   81 YFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFLGWYTTEEHLQYRKTHPDQCEFVV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKA 348
Cdd:cd15066  161 NKIYALISSSVSFWIPCIVMIFTYYRIYLEA-------------------------------------------KREHKA 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLC-DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15066  198 AKTLGIIMGAFILCWLPFFLWYVTTTLCgDACPYPPILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
 
Name Accession Description Interval E-value
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
109-415 1.99e-172

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 483.03  E-value: 1.99e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15066    1 LKGFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKV 268
Cdd:cd15066   81 YFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFLGWYTTEEHLQYRKTHPDQCEFVV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKA 348
Cdd:cd15066  161 NKIYALISSSVSFWIPCIVMIFTYYRIYLEA-------------------------------------------KREHKA 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLC-DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15066  198 AKTLGIIMGAFILCWLPFFLWYVTTTLCgDACPYPPILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
124-404 1.70e-62

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 202.53  E-value: 1.70e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294  124 GNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNA-SVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCIS 202
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLvYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294  203 VDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWyttteNYKYLKSNPHICEF------KVNKAYAIVS 276
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGW-----TLTVPEGNVTVCFIdfpedlSKPVSYTLLI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294  277 SSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlqisqipkprpsiqvEQSTISTMRRERKAARTLGIIM 356
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTLIIRTLRKSAS------------------------------KQKSSERTQRRRKALKTLAVVV 205
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281362294  357 SAFLICWLPFFLWYIVSSLCDSCITPRLLVGILF---WIGYFNSALNPIIY 404
Cdd:pfam00001 206 VVFILCWLPYHIVNLLDSLALDCELSRLLDKALSvtlWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
97-422 4.58e-19

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 87.53  E-value: 4.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294  97 DADGSSHLALVFVKCFIIGfiilaaILGNMLVIVsVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGKWMFG 176
Cdd:PHA03087  36 YDTNSTILIVVYSTIFFFG------LVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLFVM-TLPFQIYYYILFQWSFG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 177 SVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFlPI-----CSGWYTTT 251
Cdd:PHA03087 108 EFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETT-PIlfvytTKKDHETL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 252 ENYKYLKSNPHICEFKVNkayaIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhlqisqipkprps 331
Cdd:PHA03087 187 ICCMFYNNKTMNWKLFIN----FEINIIGMLIPLTILLYCYSKIL----------------------------------- 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 332 iqVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSL-----CDSCITPR---LLVGILFWIGYFNSALNPII 403
Cdd:PHA03087 228 --ITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLhilhfKSGCKAVKyiqYALHVTEIISLSHCCINPLI 305
                        330
                 ....*....|....*....
gi 281362294 404 YAYFNRDFRAAFKKTLKVS 422
Cdd:PHA03087 306 YAFVSEFFNKHKKKSLKLM 324
 
Name Accession Description Interval E-value
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
109-415 1.99e-172

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 483.03  E-value: 1.99e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15066    1 LKGFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKV 268
Cdd:cd15066   81 YFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFLGWYTTEEHLQYRKTHPDQCEFVV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKA 348
Cdd:cd15066  161 NKIYALISSSVSFWIPCIVMIFTYYRIYLEA-------------------------------------------KREHKA 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLC-DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15066  198 AKTLGIIMGAFILCWLPFFLWYVTTTLCgDACPYPPILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
109-415 9.99e-107

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 316.04  E-value: 9.99e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENykylkSNPHICEFKV 268
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPS-----VVDCECEFTP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKA 348
Cdd:cd14967  156 NKIYVLVSSVISFFIPLLIMIVLYARIFRVA-------------------------------------------RRELKA 192
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14967  193 AKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
113-415 1.06e-95

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 289.33  E-value: 1.06e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRI-ITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSvMCDMWNSFDVYFS 191
Cdd:cd15057    6 ILYLLVLLTLLGNALVIAAVLRFRHLRSkVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGS-FCDVWVSFDIMCS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWY--TTTENYKYLKSNPHICEFKVN 269
Cdd:cd15057   85 TASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLGWHraDDTSEALALYADPCQCDSSLN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyrsKVAALllekHLQISQIPKPRPSIQveqstiSTMRRERKAA 349
Cdd:cd15057  165 RTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIR-----RIAAL----ERAAQESTNPDSSLR------SSLRRETKAL 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDS------CITPRLLVgILFWIGYFNSALNPIIYAyFNRDFRAAF 415
Cdd:cd15057  230 KTLSIIMGVFVCCWLPFFILNCVLPFCDLrtaqfpCVPDTTFI-VFVWLGWANSSLNPIIYA-FNADFRKAF 299
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
112-415 3.93e-93

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 282.70  E-value: 3.93e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15065    4 IFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYT-TTENYKYL--KSNPH-ICEFK 267
Cdd:cd15065   84 TASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHLGWHRlSQDEIKGLnhASNPKpSCALD 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrQERLVyrsKVAALLLEKHLQISQIPKPRPSIQVEQSTistmrRERK 347
Cdd:cd15065  164 LNPTYAVVSSLISFYIPCLVMLLIYSRLYLYA--RKHVV---NIKSQKLPSESGSKFQVPSLSSKHNNQGV-----SDHK 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 348 AARTLGIIMSAFLICWLPFFLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15065  234 AAVTLGIIMGVFLICWLPFFIINIIAAFCKTCI-PPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
109-415 3.37e-91

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 277.29  E-value: 3.37e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15051    2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLkSNPHICEFKV 268
Cdd:cd15051   82 MLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHLGWNTPDGRVQNG-DTPNQCRFEL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVyrskvaallleKHLQISQIPKPRPSIQVeqstistmRRERKA 348
Cdd:cd15051  161 NPPYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRI-----------NALTPASTANSSKSAAT--------AREHKA 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCdSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15051  222 TVTLAAVLGAFIICWFPYFTYFTYRGLC-GDNINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
111-415 5.42e-87

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 265.35  E-value: 5.42e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15064    4 SVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTTEnykylkSNPHICEFKVNK 270
Cdd:cd15064   84 CTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICIS-LPPLFGWRTPDS------EDPSECLISQDI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKAAR 350
Cdd:cd15064  157 GYTIFSTFGAFYIPLLLMLILYWKIYRAA-------------------------------------------ARERKAAK 193
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15064  194 TLGIILGAFIVCWLPFFLVALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
112-415 1.11e-86

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 266.24  E-value: 1.11e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15058    5 LLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYL-KSNPHICEFKVNK 270
Cdd:cd15058   85 TASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMNQWWRANDPEANDcYQDPTCCDFRTNM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKvAALLLEKHLQISQIPKPRPSIQVEQSTISTMrRERKAAR 350
Cdd:cd15058  165 AYAIASSVVSFYIPLLIMIFVYARVFLIATRQLQLIDKRR-LRFQSECPAPQTTSPEGKRSSGRRPSRLTVV-KEHKALK 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVgILFWIGYFNSALNPIIYAYfNRDFRAAF 415
Cdd:cd15058  243 TLGIIMGTFTLCWLPFFIANIINVFNRNLPPGEVFL-LLNWLGYINSGLNPIIYCR-SPEFRTAF 305
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
107-415 1.57e-86

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 265.51  E-value: 1.57e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGFIILAaILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSF 186
Cdd:cd15056    1 VVLSTFLSLVILLT-ILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIV-QPLDYPliMTQRRVFIMLLMVWLSPALLSFLPICSGWYT--TTENYKYLK-SNPH 262
Cdd:cd15056   80 DVLLTTASIMHLCCIALDRYYAICcQPLVYK--MTPLRVAVMLGGCWVIPTFISFLPIMQGWNHigIEDLIAFNCaSGST 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 ICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekHLQISQIPKPRPSIQVEQSTiSTM 342
Cdd:cd15056  158 SCVFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAH--------------QIRSLQRAGSSNHEADQHRN-SRM 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15056  223 RTETKAAKTLGIIMGCFCVCWAPFFVTNIVDPFIGYRV-PYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
112-415 1.95e-86

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 264.20  E-value: 1.95e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15059    5 SIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTENYKYLKSnphiCEFKVNKA 271
Cdd:cd15059   85 TASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLF-GWKDEQPWHGAEPQ----CELSDDPG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaalllekhlqisqipkprpsiqveqstisTMRRERKAART 351
Cdd:cd15059  160 YVLFSSIGSFYIPLLIMIIVYARIYRA------------------------------------------AKRKERRFTLV 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15059  198 LGVVMGAFVLCWLPFFFTYPLVVVCKTCGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
111-415 1.15e-84

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 259.51  E-value: 1.15e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15329    4 GIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSGWytttenyKYLKSNPHICEFKVNK 270
Cdd:cd15329   84 CTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALIS-IPPLFGW-------KNKVNDPGVCQVSQDF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKAAR 350
Cdd:cd15329  156 GYQIYATFGAFYIPLIVMLVLYYKIYRAA-------------------------------------------KSERKAIK 192
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLC---DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15329  193 TLGIIMGAFTLCWLPFFILALLRPFLkpiKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
113-415 5.25e-84

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 258.06  E-value: 5.25e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGK-WMFGSVMCDMWNSFDVYFS 191
Cdd:cd15067    5 VLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGyWLFGRDWCDVWHSFDVLAS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFlPICSGWYTTTENYkylkSNPHICEFKVNKA 271
Cdd:cd15067   85 TASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISF-PAIAWWRAVDPGP----SPPNQCLFTDDSG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKAART 351
Cdd:cd15067  160 YLIFSSCVSFYIPLVVMLFTYYRIYRAA-------------------------------------------AKEQKAAKT 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLC-DSCIT-PRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15067  197 LGIVMGVFILCWLPFFVTNILIGFCpSNCVSnPDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
112-415 6.89e-80

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 248.24  E-value: 6.89e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15055    5 IVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSgwYTTTENYKYLKSNPHICEFKVNKA 271
Cdd:cd15055   85 SASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYD--NLNQPGLIRYNSCYGECVVVVNFI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVyRSKVAALLLEkhlqisqipkprpsiqvEQSTISTMRRERKAART 351
Cdd:cd15055  163 WGVVDLVLTFILPCTVMIVLYMRIFVVARSQARAI-RSHTAQVSLE-----------------GSSKKVSKKSERKAAKT 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLcdsCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15055  225 LGIVVGVFLLCWLPYYIVSLVDPY---ISTPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
111-415 5.60e-78

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 243.30  E-value: 5.60e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15314    4 YIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHiCEFKVNK 270
Cdd:cd15314   84 CTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNIKGIYYNHVACEGG-CLVFFSK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlqisqipkprpSIQ--VEQSTISTMRRERKA 348
Cdd:cd15314  163 VSSVVGSVFSFYIPAVIMLCIYLKIFLVAQRQAR--------------------------SIQsaRTKSGASSSKMERKA 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCdSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15314  217 TKTLAIVMGVFLLCWTPFFLCNIIDPFI-NYSIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
117-415 5.07e-76

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 237.33  E-value: 5.07e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15060   10 IIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTENYKYLKSnphiCEFKVNKAYAIVS 276
Cdd:cd15060   90 NLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLI-GWNDWPENFTETTP----CTLTEEKGYVIYS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 277 SSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhlqisqipkprpsiqveqstISTmRRERKAARTLGIIM 356
Cdd:cd15060  165 SSGSFFIPLLIMTIVYVKIF------------------------------------------IAT-SKERRAARTLGIIM 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 357 SAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15060  202 GVFVVCWLPFFLMYVILPFCETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
113-415 1.12e-75

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 237.88  E-value: 1.12e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15959    6 LLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWY--TTTENYKYLKSNPHICEFKVNK 270
Cdd:cd15959   86 ASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNQWWrdGADEEAQRCYDNPRCCDFVTNM 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEkhlqiSQIPKPRPSIQVEQSTISTMrRERKAAR 350
Cdd:cd15959  166 PYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVRLIRKDKVRFPPEE-----SPPAESRPACGRRPSRLLAI-KEHKALK 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVgILFWIGYFNSALNPIIYAYfNRDFRAAF 415
Cdd:cd15959  240 TLGIIMGTFTLCWLPFFVANIIKVFCRSLVPDPAFL-FLNWLGYANSAFNPIIYCR-SPDFRSAF 302
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
108-415 5.81e-72

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 227.38  E-value: 5.81e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFD 187
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTE---NYKYLKSNPHIC 264
Cdd:cd15063   81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLV-GWNDGKDgimDYSGSSSLPCTC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRR 344
Cdd:cd15063  160 ELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAA-------------------------------------------RM 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 345 ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPrLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15063  197 ETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPP-LLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
107-415 1.18e-71

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 228.35  E-value: 1.18e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIiGFIILAAILGNMLVIVSVMRHRKLRI-ITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSvMCDMWNS 185
Cdd:cd15320    2 VLTGCFL-SVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 186 FDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTE------NYKYLKS 259
Cdd:cd15320   80 FDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQLNWHKAKPtsfldlNASLRDL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 260 NPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTI 339
Cdd:cd15320  160 TMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQNSTGNRGSGDCQQPESSFK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 340 STMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDS------CITPRLLvGILFWIGYFNSALNPIIYAyFNRDFRA 413
Cdd:cd15320  240 MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPtstepfCISSTTF-DVFVWFGWANSSLNPIIYA-FNADFRK 317

                 ..
gi 281362294 414 AF 415
Cdd:cd15320  318 AF 319
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
117-415 1.36e-71

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 226.07  E-value: 1.36e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMIS-GKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15053   10 LPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNgGKWYLGPILCDIYIAMDVMCSTASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTTENykylksNPHICEFkVNKAYAIV 275
Cdd:cd15053   90 FNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIA-CPLLFGLNNVPYR------DPEECRF-YNPDFIIY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 276 SSSMSFWIPGIVMLSMYYRIYQeadrqerlvyrskvaalllekhlqisqipkprpsiqveqstisTMRRERKAARTLGII 355
Cdd:cd15053  162 SSISSFYIPCIVMLLLYYRIFR-------------------------------------------ALRREKKATKTLAIV 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 356 MSAFLICWLPFFLWYIVSSLC-----DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15053  199 LGVFLFCWLPFFTLNILNAICpklqnQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
113-415 2.02e-71

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 227.05  E-value: 2.02e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15957    6 VMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTE-NYKYLKSNPHICEFKVNKA 271
Cdd:cd15957   86 ASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHqEAINCYAEETCCDFFTNQA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVaalllEKHLQISQIPKPRPSIQVEQSTISTMrRERKAART 351
Cdd:cd15957  166 YAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEG-----RFHNQNIDQNGSGGGGGNRRRSKFCL-KEHKALKT 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYfNRDFRAAF 415
Cdd:cd15957  240 LGIIMGTFTLCWLPFFIVNIVHVIQDNLI-RKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAF 301
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
111-415 2.10e-71

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 225.70  E-value: 2.10e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15331    4 SIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQpLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIcSGWytTTENYKYLKSNPHICEFKVNK 270
Cdd:cd15331   84 CTASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAPL-FGW--KDEDDLDRVLKTGVCLISQDY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKAAR 350
Cdd:cd15331  160 GYTIFSTVGAFYVPLLLMIIIYWKIYQAA-------------------------------------------KRERKAAR 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15331  197 TLAIITGAFVVCWLPFFLVALVMPFCGAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
107-415 1.79e-68

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 218.00  E-value: 1.79e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIgfIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSF 186
Cdd:cd15061    1 ILISFLIL--AIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYttTENYKYLKSnphiCEF 266
Cdd:cd15061   79 DVLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLV-GPS--WHGRRGLGS----CYY 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrSKVAAlllekhlqisqipkprpsiqveqstistmrRER 346
Cdd:cd15061  152 TYDKGYRIYSSMGSFFLPLLLMLFVYLRI-------------FRVIA------------------------------KER 188
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 347 KAARTLGIIMSAFLICWLPFFLWYIVSSLCDsCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15061  189 KTAKTLAIVVGCFIVCWLPFFIMYLIEPFCD-CQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
113-415 1.81e-68

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 219.39  E-value: 1.81e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15958    6 LMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKY-LKSNPHICEFKVNKA 271
Cdd:cd15958   86 ASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMMHWWRDEDDQALkCYEDPGCCDFVTNRA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVyrSKVAALLLEKHLQISQIPKPRPSIQVeqstistMRRERKAART 351
Cdd:cd15958  166 YAIASSIISFYIPLLIMIFVYLRVYREAKKQIKKI--DKCEGRFHNTLTGLGRKCKRRPSRIL-------ALREQKALKT 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVgILFWIGYFNSALNPIIYAYfNRDFRAAF 415
Cdd:cd15958  237 LGIIMGVFTLCWLPFFLVNVVNVFNRELVPDWLFV-FFNWLGYANSAFNPIIYCR-SPDFRKAF 298
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
112-408 3.21e-68

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 217.93  E-value: 3.21e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd00637    3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsgWYTTTENYKYLKSNPHICEFKVNKA 271
Cdd:cd00637   83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLL--GWGVYDYGGYCCCCLCWPDLTLSKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlqisqipkPRPSIQVEQSTISTMRRERKAART 351
Cdd:cd00637  161 YTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRR-----------------------RIRSSSSNSSRRRRRRRERKVTKT 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLC-DSCITPRLLVGILFWIGYFNSALNPIIYAYFN 408
Cdd:cd00637  218 LLIVVVVFLLCWLPYFILLLLDVFGpDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
112-415 2.05e-67

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 215.53  E-value: 2.05e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15326    5 LVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTENYKYlksnphICEFKVNKA 271
Cdd:cd15326   85 TASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLL-GWKEPAPPDDK------VCEITEEPF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskVAALllekhlqisqipkprpsiqveqstisTMRRERKAART 351
Cdd:cd15326  158 YALFSSLGSFYIPLIVILVMYCRVY--------------IVAL--------------------------KFSREKKAAKT 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15326  198 LGIVVGMFILCWLPFFIALPLGSLFSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
118-415 3.25e-66

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 212.98  E-value: 3.25e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 118 ILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMH 197
Cdd:cd15312   11 ILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFH 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 198 LCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTT-TENYKYLKSNPHICEFKVNKAYAIVS 276
Cdd:cd15312   91 LCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEgIEDYVALVSCTGSCVLIFNKLWGVIA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 277 SSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlQISQIPKPRPSiqVEQSTISTmRRERKAARTLGIIM 356
Cdd:cd15312  171 SLIAFFIPGTVMIGIYIKIFFVARKHAK----------------VINNRPSVTKG--DSKNKLSK-KKERKAAKTLSIVM 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 357 SAFLICWLPFFLWYIVSSLCDSCiTPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15312  232 GVFLLCWLPFFVATLIDPFLNFS-TPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
113-415 2.19e-64

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 207.34  E-value: 2.19e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15062    6 ALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTENykylksNPHICEFKVNKAY 272
Cdd:cd15062   86 ASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLL-GWKEPAPA------DEQACGVNEEPGY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYQEADRqerlvyrskvaalllekhlqisqipkprpsiqveqstistMRRERKAARTL 352
Cdd:cd15062  159 VLFSSLGSFYLPLAIILVMYCRVYVVAFK----------------------------------------FSREKKAAKTL 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15062  199 GIVVGAFVLCWFPFFVVLPLGSLFSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
113-415 6.79e-64

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 208.27  E-value: 6.79e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRI-ITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSvMCDMWNSFDVYFS 191
Cdd:cd15319    6 LLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGA-FCDVWVAFDIMCS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTT-------ENYKYLKSNPHIC 264
Cdd:cd15319   85 TASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDSgddwvglHNSSISRQVEENC 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAAllleKHLQISQipKPRPSIQVEQSTISTMRR 344
Cdd:cd15319  165 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIRRISSLERAA----EHAQSCR--SNRIDCHHHTSLRTSIKK 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 345 ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDS----------CITPRLLvGILFWIGYFNSALNPIIYAyFNRDFRAA 414
Cdd:cd15319  239 ETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRppadpdaglpCVSETTF-DVFVWFGWANSSLNPIIYA-FNADFRKV 316

                 .
gi 281362294 415 F 415
Cdd:cd15319  317 F 317
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
109-415 3.35e-63

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 204.44  E-value: 3.35e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15330    2 ITSLFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTEnykylKSNPHICEFKV 268
Cdd:cd15330   82 LCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPML-GWRTPED-----RSDPDACTISK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKA 348
Cdd:cd15330  156 DPGYTIYSTFGAFYIPLILMLVLYGRIFKAA-------------------------------------------ARERKT 192
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDS-CITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15330  193 VKTLGIIMGTFILCWLPFFIVALVLPFCEStCHMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
112-415 5.71e-63

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 204.99  E-value: 5.71e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15317    5 IVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTT-TENYKYLKSNPHICEFKVNK 270
Cdd:cd15317   85 TTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEgLEEYSSEISCVGGCQLLFNK 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVsSSMSFWIPGIVMLSMYYRIYQEADRQERLVyrskvaalllekhlqisQIPKPRPSIQVEQSTISTMRRERKAAR 350
Cdd:cd15317  165 IWVLL-DFLTFFIPCLIMIGLYAKIFLVARRQARKI-----------------QNMEDKFRSSEENSSKASASRERKAAK 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCDsCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15317  227 TLAIVMGIFLFCWLPYFIDTIVDEYSN-FITPAIVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
112-415 1.43e-62

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 202.93  E-value: 1.43e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFN-ASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15052    5 LLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSiLTELFGGVWPLPLVLCLLWVTLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPIC-SGWYTTTENYKYLKSNPHicefkvN 269
Cdd:cd15052   85 CTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGIS-SPIPvLGIIDTTNVLNNGTCVLF------N 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRiyqeadrqerlvyrskvaalllekhlqisqipkprpsiqveqsTISTMRRERKAA 349
Cdd:cd15052  158 PNFVIYGSIVAFFIPLLIMVVTYAL-------------------------------------------TIRLLSNEQKAS 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSC---ITPRLLvGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15052  195 KVLGIVFAVFVICWCPFFITNILTGLCEECncrISPWLL-SVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
124-404 1.70e-62

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 202.53  E-value: 1.70e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294  124 GNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNA-SVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCIS 202
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLvYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294  203 VDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWyttteNYKYLKSNPHICEF------KVNKAYAIVS 276
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGW-----TLTVPEGNVTVCFIdfpedlSKPVSYTLLI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294  277 SSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlqisqipkprpsiqvEQSTISTMRRERKAARTLGIIM 356
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTLIIRTLRKSAS------------------------------KQKSSERTQRRRKALKTLAVVV 205
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281362294  357 SAFLICWLPFFLWYIVSSLCDSCITPRLLVGILF---WIGYFNSALNPIIY 404
Cdd:pfam00001 206 VVFILCWLPYHIVNLLDSLALDCELSRLLDKALSvtlWLAYVNSCLNPIIY 256
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
113-415 8.26e-62

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 200.89  E-value: 8.26e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15325    6 ILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIcSGWYTTTenykylKSNPHICEFKVNKAY 272
Cdd:cd15325   86 ASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPL-FGWKEPA------PEDETICQITEEPGY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskVAALllekhlqisqipkprpsiqveqstisTMRRERKAARTL 352
Cdd:cd15325  159 ALFSALGSFYLPLAIILVMYCRVY--------------VVAL--------------------------KFSREKKAAKTL 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15325  199 GIVVGCFVLCWLPFFLVMPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
113-415 2.17e-61

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 199.78  E-value: 2.17e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15323    6 VVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSgWYTTTENYKYLKsnphiCEFKVNKAY 272
Cdd:cd15323   86 SSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLIS-MYRDPEGDVYPQ-----CKLNDETWY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYQEADrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKAARTL 352
Cdd:cd15323  160 ILSSCIGSFFAPCLIMILVYIRIYRVAK------------------------------------------AREKRFTFVL 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLC-DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15323  198 AVVMGVFVVCWFPFFFSYSLYGICrEACEVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
113-415 2.32e-60

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 197.06  E-value: 2.32e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15327    6 FLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTenykylKSNPHICEFKVNKAY 272
Cdd:cd15327   86 ASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLL-GWKEPP------PPDESICSITEEPGY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskVAALllekhlqisqipkprpsiqveqstisTMRRERKAARTL 352
Cdd:cd15327  159 ALFSSLFSFYLPLMVILVMYFRVY--------------VVAL--------------------------KFSREKKAAKTL 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15327  199 AIVVGVFILCWFPFFFVLPLGSFFPALKPSEMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
111-415 3.19e-59

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 194.08  E-value: 3.19e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15049    4 CIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWyTTTENYKYLKSNPHICEFKVNK 270
Cdd:cd15049   84 SNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAIL-GW-QYFVGERTVPDGQCYIQFLDDP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKAAR 350
Cdd:cd15049  162 AITFGTAIAAFYLPVLVMTILYWRIYRET-------------------------------------------ARERKAAR 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15049  199 TLSAILLAFIITWTPYNILVLVSTFCAKCI-PDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
113-415 1.24e-57

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 190.16  E-value: 1.24e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15322    6 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIcsgwytTTENYKYLKSNPHICEFKVNKAY 272
Cdd:cd15322   86 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL------ITIEKKSGQPEGPICKINDEKWY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYQEADRqerlvyrskvaalllekhlqisqipkprpsiqveqstistmrRERKAARTL 352
Cdd:cd15322  160 IISSCIGSFFAPCLIMVLVYIRIYQIAKN------------------------------------------REKRFTFVL 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDsCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15322  198 AVVIGVFVICWFPFFFTYTLTAVCD-CSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
112-415 1.16e-56

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 188.67  E-value: 1.16e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15048    5 VLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYTTTEnYKYLKSNPHICEFKVNKA 271
Cdd:cd15048   85 TASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWIL-AFLLYGPAIIGWDLWTG-YSIVPTGDCEVEFFDHFY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALllekhlqisqIPKPRPSIQVEQSTISTMRRERKAART 351
Cdd:cd15048  163 FTFITSVLEFFIPFISVSFFNLLIYLNIRKRSRRRPLRSVPIL----------PASQNPSRARSQREQVKLRRDRKAAKS 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLC-DSCITPRLLVgILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15048  233 LAILVLVFLICWAPYTILTIIRSFCsGSCVDSYLYE-FTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
117-415 1.81e-56

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 187.10  E-value: 1.81e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGK-WMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15310   10 LILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGvWNFSRICCDVFVTLDVMMCTASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQ---RRVFIMLLMVWLSPALLSfLPICSGWYTTtenykylkSNPHICEFKvNKAY 272
Cdd:cd15310   90 LNLCAISIDRYTAVVMPVHYQHGTGQsscRRVSLMITAVWVLAFAVS-CPLLFGFNTT--------GDPTVCSIS-NPDF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhlqisqipkprpsiqveqstiSTMRRERKAARTL 352
Cdd:cd15310  160 VIYSSVVSFYLPFGVTLLVYVRIY-------------------------------------------VVLLREKKATQML 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15310  197 AIVLGAFIVCWLPFFLTHILNTHCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
113-415 1.97e-56

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 187.05  E-value: 1.97e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15321   12 AITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSgwyttTENYKYLKSNPHICEFKVNKAY 272
Cdd:cd15321   92 SSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIY-----KGKQKDEQGGLPQCKLNEEAWY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYQEADRqerlvyrskvaalllekhlqisqipkprpsiqveqstistmrRERKAARTL 352
Cdd:cd15321  167 ILSSSIGSFFAPCLIMILVYLRIYLIAKN------------------------------------------REKRFTFVL 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLC-DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15321  205 AVVIGVFVLCWFPFFFSYSLGAICpELCKVPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
112-415 2.46e-56

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 186.93  E-value: 2.46e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15054    5 AFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWY-----TTTENYKYLKSNPHiCEF 266
Cdd:cd15054   85 SASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHelgheRTLPNLTSGTVEGQ-CRL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRER 346
Cdd:cd15054  164 LVSLPYALVASCLTFFLPSGAICFTYCRILLAA-------------------------------------------RKAL 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 347 KAARTLGIIMSAFLICWLPFFLWYIVSSLCDsCITPRLLvGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15054  201 KASLTLGILLGMFFVTWLPFFVANVVQAVCD-CVSPGLF-DVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
104-415 3.35e-55

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 183.84  E-value: 3.35e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 104 LALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMW 183
Cdd:cd15333    1 LGLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 184 NSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsgwytttenYKYLKSNPHI 263
Cdd:cd15333   81 LSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFF---------WRQAKAEEEV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 264 CEFKVNK---AYAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstis 340
Cdd:cd15333  152 SECVVNTdhiLYTVYSTVGAFYIPTLLLIALYGRIYVEA----------------------------------------- 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 341 tMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLC-DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15333  191 -RARERKATKTLGIILGAFIVCWLPFFIISLVLPICkDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
113-415 2.97e-54

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 181.22  E-value: 2.97e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15324    6 VVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTEnykylksnphiCEFKVNKAY 272
Cdd:cd15324   86 SSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDEWE-----------CLLNDETWY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrsKVAALllekhlqisqipkprpsiqveqstistmrRERKAARTL 352
Cdd:cd15324  155 ILSSCTVSFFAPGLIMILVYCKIY-------------RVAKM-----------------------------REKRFTFVL 192
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLC-DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15324  193 AVVMGVFVLCWFPFFFTYSLHAVCrKRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
113-415 4.70e-54

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 180.70  E-value: 4.70e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15050    6 ALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVAST 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspaLLSFL---PICSGWYTTTENYKYLKSNPHICEFKVN 269
Cdd:cd15050   86 ASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAW----LLSFLwviPILGWHHFARGGERVVLEDKCETDFHDV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaalllekhlqisqipkprpsiqveqstistMRRERKAA 349
Cdd:cd15050  162 TWFKVLTAILNFYIPSLLMLWFYAKIFKA-------------------------------------------VNRERKAA 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVgILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15050  199 KQLGFIMAAFILCWIPYFILFMVIAFCKNCCNENLHM-FTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
125-416 9.14e-52

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 174.75  E-value: 9.14e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 125 NMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVD 204
Cdd:cd15334   18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 205 RYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHIcefkvnkAYAIVSSSMSFWIP 284
Cdd:cd15334   98 RYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSREDECIIKHDHI-------VFTIYSTFGAFYIP 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 285 GIVMLSMYYRIYQEADrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmrRERKAARTLGIIMSAFLICWL 364
Cdd:cd15334  171 LALILILYYKIYRAAT-------------------------------------------RERKAATTLGLILGAFVICWL 207
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 281362294 365 PFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFK 416
Cdd:cd15334  208 PFFVKEVIVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
112-415 2.05e-50

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 172.40  E-value: 2.05e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGF--IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVY 189
Cdd:cd14993    3 LIVLYvvVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLsFLPICSGwYTTTENYKYLKSNPHIC---EF 266
Cdd:cd14993   83 SVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIII-MLPLLVV-YELEEIISSEPGTITIYictED 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 ----KVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlVYRskvaalllekhLQISQIPKPRPSIQVEQSTISTM 342
Cdd:cd14993  161 wpspELRKAYNVALFVVLYVLPLLIISVAYSLI----------GRR-----------LWRRKPPGDRGSANSTSSRRILR 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 343 RReRKAARTLGIIMSAFLICWLPFFLWYIV-----SSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14993  220 SK-KKVARMLIVVVVLFALSWLPYYVLSILldfgpLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
112-415 1.75e-49

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 168.48  E-value: 1.75e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFI-ILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMT-FNASVMISGKWMFGSVMCDMWNSFDVY 189
Cdd:cd15308    4 LVGGVLlILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPlYVYSEFQGGVWTLSPVLCDALMTMDVM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVW-LSPALLSflPICSGWYTTTENykylksNPHICEFKV 268
Cdd:cd15308   84 LCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWiLSFAVAS--PVIFGLNNVPNR------DPAVCKLED 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKaYAIVSSSMSFWIPGIVMLSMYYRIYQeadrqerlvyrskvaalllekhlqisqipkprpsiqveqstisTMRRERKA 348
Cdd:cd15308  156 NN-YVVYSSVCSFFIPCPVMLVLYCAMFR-------------------------------------------GLGRERKA 191
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15308  192 MRVLPVVVGAFLFCWTPFFVVHITRALCESCSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
117-415 4.19e-48

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 165.89  E-value: 4.19e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFnaSVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd14968   10 IAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPL--AILISLGLPTNFHGCLFMACLVLVLTQSSIF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTENYKYLKSNPHICEF-KVNKAYAIV 275
Cdd:cd14968   88 SLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMF-GWNNGAPLESGCGEGGIQCLFeEVIPMDYMV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 276 SSSMSFWI--PGIVMLSMYYRIYQEADRQERlvyrsKVAALLLEKHLQisqipkprpsiqveqstiSTMRRERKAARTLG 353
Cdd:cd14968  167 YFNFFACVlvPLLIMLVIYLRIFRVIRKQLR-----QIESLLRSRRSR------------------STLQKEVKAAKSLA 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 354 IIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14968  224 IILFLFALCWLPLHIINCITLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
113-415 1.01e-47

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 163.97  E-value: 1.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISG-KWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15328    6 LLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGrRWQLGRSLCQVWISFDVLCC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWyttTENYkylKSNPHICEFKVNKA 271
Cdd:cd15328   86 TASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGW---GETY---SEDSEECQVSQEPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKAART 351
Cdd:cd15328  160 YTVFSTFGAFYLPLCVVLFVYWKIYKAA-------------------------------------------QKEKRAALM 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCdSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15328  197 VGILIGVFVLCWIPFFLTELISPLC-SCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
113-414 3.46e-46

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 161.18  E-value: 3.46e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15316    6 VLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTT-TENYKYLKSNPHICEFKVNKA 271
Cdd:cd15316   86 ASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYTGVNDDgLEELVNALNCVGGCQIILNQN 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVsSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSkvaalllekhlqisqipkprpSIQVEQSTIS----TMRRERK 347
Cdd:cd15316  166 WVLV-DFLLFFIPTFAMIILYGKIFLVAKQQARKIEMT---------------------SSKAESSSESykdrVARRERK 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 348 AARTLGIIMSAFLICWLPfflwYIVSSLCDS---CITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15316  224 AAKTLGITVIAFLVSWLP----YLIDVLIDAfmnFITPPYIYEICCWCAYYNSAMNPLIYALFYPWFRKA 289
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
107-423 5.07e-46

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 160.11  E-value: 5.07e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSF 186
Cdd:cd15299    3 VVLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL------SPALLsflpicsgWYTTTENYKYLKSN 260
Cdd:cd15299   83 DYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVisfvlwAPAIL--------FWQYFVGKRTVPPD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 261 PHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaalllekhlqisqipkprpsiqveqsTIs 340
Cdd:cd15299  155 ECFIQFLSEPIITFGTAIAAFYLPVTIMTILYWRIYKE---------------------------------------TI- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 341 tmrRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLK 420
Cdd:cd15299  195 ---KEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCI-PKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLL 270

                 ...
gi 281362294 421 VSC 423
Cdd:cd15299  271 CQC 273
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
115-415 6.50e-46

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 159.36  E-value: 6.50e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd17790    8 GILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLsFLPICSGWYTTTENYKYLKSNPHIcEFKVNKAYAI 274
Cdd:cd17790   88 VMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVL-WAPAILFWQYLVGERTVLAGQCYI-QFLSQPIITF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 275 VSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaalllekhlqisqipkprpsiqveqsTIstmrRERKAARTLGI 354
Cdd:cd17790  166 GTAIAAFYLPVTIMIILYWRIYRE---------------------------------------TI----KEKKAARTLSA 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 355 IMSAFLICWLPFFLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd17790  203 ILLAFILTWTPYNIMVLVSTFCKDCV-PKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
114-414 2.31e-45

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 158.48  E-value: 2.31e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 114 IGFIILaaILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTA 193
Cdd:cd15318    9 IGMLII--VLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 194 SIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENyKYLKSNPHI--CEFKVNKA 271
Cdd:cd15318   87 SIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLA-ELLTSVPCVgsCQLLYNKL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMsFWIPGIVMLSMYYRIYQEADRQERLVyrskvaalllekhlqisqipkprpsIQVEQSTISTMRRERKAART 351
Cdd:cd15318  166 WGWLNFPV-FFIPCLIMIGLYVKIFIVAKRQARAI-------------------------ASLLSDTNGASKRERKAAKT 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDScITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15318  220 LGIAVGVYLLCWLPFTIDTMVDSLLNF-ITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFRKA 281
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
111-415 5.65e-45

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 157.01  E-value: 5.65e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15335    4 VLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsgWYTttenyKYLKSNPHICEFKVNK 270
Cdd:cd15335   84 CTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLF--WRN-----HHDANIPSQCIIQHDH 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 A-YAIVSSSMSFWIPGIVMLSMYYRIYQEADrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmrRERKAA 349
Cdd:cd15335  157 ViYTIYSTFGAFYIPLTLILILYYRIYHAAS-------------------------------------------RERKAA 193
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRlLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15335  194 RILGLILGAFILSWLPFFIKELIVGLSVMTVSPE-VADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
112-420 1.91e-44

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 156.15  E-value: 1.91e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFN-ASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15306    5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIAlLTILFEAMWPLPLVLCPIWLFLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENykylkSNPHICEFKVN- 269
Cdd:cd15306   85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDN-----PNNITCVLTKEr 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 -KAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQerlvyrskvaalllekhlqisqipkprpsiqveqstisTMRRERKA 348
Cdd:cd15306  160 fGDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQ--------------------------------------TITNEQRA 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDSC--ITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLK 420
Cdd:cd15306  202 SKVLGIVFFLFLLMWCPFFITNITSVLCDSCnqTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYIT 275
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
117-420 3.99e-44

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 155.11  E-value: 3.99e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15307   10 LVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIM 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPIcSGWYTTTENYKYLKSnphICEFKVNkAYAIVS 276
Cdd:cd15307   90 HLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMS-LPL-SLMYSKDHASVLVNG---TCQIPDP-VYKLVG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 277 SSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaallleKHLQIsqipkprpsiqveqstistMRRERKAARTLGIIM 356
Cdd:cd15307  164 SIVCFYIPLGVMLLTYCLTVRLLARQRS-------------RHGRI-------------------IRLEQKATKVLGVVF 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 357 SAFLICWLPFFLWYIVSSLCDSCIT--PRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLK 420
Cdd:cd15307  212 FTFVILWSPFFVLNLLPTVCAECEEriSHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLL 277
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
115-415 9.12e-44

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 154.45  E-value: 9.12e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAIL------GNMLVIVSVMRHRKLRI-ITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFD 187
Cdd:cd15104    1 AAGVILAVLspliitGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTenykylkSNPHICEF- 266
Cdd:cd15104   81 ITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQT-------SYKGKCSFf 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 -KVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALllekhlqiSQIPKPRPSiqveqstistmrRE 345
Cdd:cd15104  154 aAFHPRVLLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALA--------RQIHPRRTL------------SD 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 346 RKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15104  214 FKAARTVAVLIGCFLLSWLPFQITGLVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
112-420 6.41e-43

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 151.98  E-value: 6.41e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFN-ASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15305    5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSlIAILYDYAWPLPRYLCPIWISLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVW-LSPALLSFLPICSgwytTTENYKYLKSNphICEFKvN 269
Cdd:cd15305   85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWtISIGISMPIPVIG----LQDDEKVFVNG--TCVLN-D 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQErlvyrskvaalllekhlqisqipkprpsiqveqstisTMRRERKAA 349
Cdd:cd15305  158 ENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQ-------------------------------------AINNERRAS 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGIL---FWIGYFNSALNPIIYAYFNRDFRAAFKKTLK 420
Cdd:cd15305  201 KVLGIVFFLFLIMWCPFFITNILSVLCKEACDQKLMEELLnvfVWVGYVSSGINPLVYTLFNKTYRRAFSNYIR 274
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
111-415 1.38e-41

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 148.60  E-value: 1.38e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGF--IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15390    2 LWSIVFvvMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPliMTQRRVFIMLLMVWLSPALLSFlPICsgWYTTTENYKYLKS--------- 259
Cdd:cd15390   82 TTVAASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLAL-PQL--LYSTTETYYYYTGsertvcfia 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 260 NPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaalllekhLQISQIPKPRPSIQVEQsti 339
Cdd:cd15390  157 WPDGPNSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVE---------------------LWGSKTIGENTPRQLES--- 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 340 stMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGI---LFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15390  213 --VRAKRKVVKMMIVVVVIFAICWLPYHLYFILTYLYPDINSWKYIQQIylaIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
113-415 1.58e-41

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 147.81  E-value: 1.58e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15297    6 VAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL------SPALLsFLPICSGWYTTTENYKYLksnphicEF 266
Cdd:cd15297   86 ASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVlsfilwAPAIL-FWQFIVGGRTVPEGECYI-------QF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrSKVAAlllekhlqisqipkprpsiqveqstistmrRER 346
Cdd:cd15297  158 FSNAAVTFGTAIAAFYLPVIIMTVLYWQI-------------SRASS------------------------------REK 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 347 KAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15297  195 KVTRTILAILLAFIITWTPYNVMVLINTFCASCI-PNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
113-415 2.33e-41

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 147.10  E-value: 2.33e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15309    6 LLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPL-IMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTTENykylksnphICeFKVNKA 271
Cdd:cd15309   86 ASILNLCAISIDRYTAVAMPMLYNTrYSSKRRVTVMISVVWVLSFAIS-CPLLFGLNNTDQN---------EC-IIANPA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhlqisqipkprpsiqveqstiSTMRRERKAART 351
Cdd:cd15309  155 FVVYSSIVSFYVPFIVTLLVYVQIY-------------------------------------------IVLQKEKKATQM 191
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDsCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15309  192 LAIVLGVFIICWLPFFITHILNMHCD-CNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
117-415 4.43e-41

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 147.00  E-value: 4.43e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISG-KWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15304   10 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFSTASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSF-LPIcsgwYTTTENYKYLKSNPHICefkVNKAYAI 274
Cdd:cd15304   90 MHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMpIPV----FGLQDDSKVFKEGSCLL---ADENFVL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 275 VSSSMSFWIPGIVMLSMYYRiyqeadrqerlvyrskvaalllekhlqisqipkprpSIQVEQSTISTmrrERKAARTLGI 354
Cdd:cd15304  163 IGSFVAFFIPLTIMVITYFL------------------------------------TIKSLQQSISN---EQKASKVLGI 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 355 IMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGIL---FWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15304  204 VFFLFVVMWCPFFITNVMAVICKESCNEVVIGGLLnvfVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
113-415 4.53e-41

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 146.81  E-value: 4.53e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTF-NASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15302    6 ITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFyTVYVLNGDYWPLGWVLCDLWLSVDYTVC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIcSGWYTTTENYKYLKSNPHICEFKVNKA 271
Cdd:cd15302   86 LVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISI-FGWQYFTGQGRSLPEGECYVQFMTDPY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEADRQerlvyrskvaalllekhlqisqipkprpsiqveqstistmrreRKAART 351
Cdd:cd15302  165 FNMGMYIGYYWTTLIVMLILYAGIYRAANRA-------------------------------------------RKALRT 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCD--SCITPRLLVgILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15302  202 ITFILGAFVICWTPYHILATIYGFCEapPCVNETLYT-ISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
112-415 2.25e-40

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 145.43  E-value: 2.25e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCdMWNSFDVYFS 191
Cdd:cd14969    5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGC-VIYGFAVTFL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 T-ASIMHLCCISVDRYYAIVQPLDYpLIMTQRRVFIMLLMVWLSPALLSFLPICsGWytttENYKYLKSNpHICEF---- 266
Cdd:cd14969   84 GlVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALPPLF-GW----SSYVPEGGG-TSCSVdwys 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 --KVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaalllekhlqISQIPKPRPSIQVEQSTISTMRR 344
Cdd:cd14969  157 kdPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRT-----------------------LRKMSKRAARRKNSAITKRTKKA 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 345 ERKAARTLGIIMSAFLICWLPfflwYIVSSLCDSCITPRLLVGILFWIGYFNSAL----NPIIYAYFNRDFRAAF 415
Cdd:cd14969  214 EKKVAKMVLVMIVAFLIAWTP----YAVVSLYVSFGGESTIPPLLATIPALFAKSstiyNPIIYVFMNKQFRRAL 284
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
112-415 1.17e-39

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 143.53  E-value: 1.17e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGF--IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVY 189
Cdd:cd15207    3 FIVSYslIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTASIMHLCCISVDRYYAIVQPLDYPliMTQRRVFIMLLMVWLSPALLSflpICSGWYTTTENYKYLKSNP-HIC-EF- 266
Cdd:cd15207   83 SVAASVFTLVAIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIWVLALAIM---IPQALVLEVKEYQFFRGQTvHICvEFw 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 ---KVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllekHLQISQIPKPRPSIQVEQSTISTMR 343
Cdd:cd15207  158 psdEYRKAYTTSLFVLCYVAPLLIIAVLYVRI-----------------------GYRLWFKPVPGGGSASREAQAAVSK 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 344 RERKAARTLGIIMSAFLICWLPFflwYIVSSLCDSCITPRLLVGILF--------WIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15207  215 KKVRVIKMLIVVVVLFALSWLPL---HTVTMLDDFGNLSPNQREVLYvyiypiahWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
113-415 1.03e-38

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 140.55  E-value: 1.03e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15300    6 VTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTEnyKYLKSNPHICEFKVNKAY 272
Cdd:cd15300   86 ASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFVGK--RTVPERECQIQFLSEPTI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaalllekhlqisqipkprpsiqveqsTIstmrRERKAARTL 352
Cdd:cd15300  164 TFGTAIAAFYIPVSVMTILYCRIYKE---------------------------------------TI----KERKAAQTL 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15300  201 SAILLAFIITWTPYNIMVLVSTFCSDCI-PLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
112-415 7.57e-37

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 136.20  E-value: 7.57e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSF---DV 188
Cdd:cd15203    5 LLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLqgvSI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMhlcCISVDRYYAIVQPLDYPliMTQRRVFIMLLMVWLSPALLSfLPIcsGWYTTTENYKY--LKSNPHICE- 265
Cdd:cd15203   85 FVSTLTLT---AIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLLS-LPL--AIFQELSDVPIeiLPYCGYFCTe 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 ----FKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQeadrqeRLvyrskvaalllekHLQISQIPKPRPSIQVEQStiST 341
Cdd:cd15203  157 swpsSSSRLIYTISVLVLQFVIPLLIISFCYFRISL------KL-------------RKRVKKKRGKRTLSSRRRR--SE 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 342 MRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITP---RLLVGILF-WIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15203  216 LRRKRRTNRLLIAMVVVFAVCWLPLNLFNLLRDFEPLPQIDgrhFYLIFLIChLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
113-412 1.26e-36

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 134.95  E-value: 1.26e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15301    5 IVAAVLsLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLAS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWyTTTENYKYLKSNPHICEFKVNKA 271
Cdd:cd15301   85 NASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWII-SLLLWPPWIYSW-PYIEGKRTVPAGTCYIQFLETNP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSM-SFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKAAR 350
Cdd:cd15301  163 YVTFGTALaAFYVPVTIMCILYWRIWRETKKRQK--------------------------------------KQESKAAK 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSL--CDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15301  205 TLSAILLAFIVTWTPYNVLVLIKAFfpCSDTI-PTELWDFSYYLCYINSTINPLCYALCNAAFR 267
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
117-415 3.28e-36

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 134.48  E-value: 3.28e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd14992   10 IILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSflpICSGWYTTTE--------NYKYLKSNPHICEFKV 268
Cdd:cd14992   90 TLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLA---IPQLYYATTEvlfsvknqEKIFCCQIPPVDNKTY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqERLVYRSKVaalllekhlqisqipkprPSIQVEQSTISTMRRERKA 348
Cdd:cd14992  167 EKVYFLLIFVVIFVLPLIVMTLAYARI-------SRELWFRKV------------------PGFSIKEVERKRLKCKRRV 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITP---RLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14992  222 IKMLVCVVVLFVICWLPFHLFFLLRDFFPLIMKEkhtLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
106-415 4.52e-36

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 134.14  E-value: 4.52e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 106 LVFVKCFIIgfIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNS 185
Cdd:cd15205    1 TAFVITYVL--IFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 186 FDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspaLLSFLPICSGWYTTT--ENYKYLKSNPHI 263
Cdd:cd15205   79 VQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVW----IVSVIVGSPMLFVQQleVKYDFLYEKRHV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 264 C------EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaaLLLEKHLQISQIPKPRPSIqvEQS 337
Cdd:cd15205  155 CclerwySPTQQKIYTTFILVILFLLPLTTMLFLYSRIGYE---------------LWIKKRVGDASVLQTIHGI--EMS 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 338 TIStmRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSC-----ITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15205  218 KIS--RKKKRAVKMMVTVVLLFAVCWAPFHVVHMMIEYSNLEnkydgVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFK 295

                 ...
gi 281362294 413 AAF 415
Cdd:cd15205  296 KNF 298
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
113-415 2.13e-35

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 131.68  E-value: 2.13e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15298    6 VTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL------SPALLsFLPICSGWYTTTENYKYLksnphicEF 266
Cdd:cd15298   86 ASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVlsfvlwAPAIL-FWQFVVGKRTVPDNQCFI-------QF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrSKVAAlllekhlqisqipkprpsiqveqstistmrRER 346
Cdd:cd15298  158 LSNPAVTFGTAIAAFYLPVVIMTVLYIHI-------------SLASA------------------------------RER 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 347 KAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15298  195 KVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCI-PDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
111-415 5.71e-34

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 128.66  E-value: 5.71e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFII--LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15208    2 VLIALYILvfIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLimTQRRVFIMLLMVWLSpALLSFLP-----ICSGWYTTTENYKYLKS-NPH 262
Cdd:cd15208   82 VSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIV-SLLIMIPqaivmECSRVVPLANKTILLTVcDER 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 ICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVaalllekhlqisQIPKPRPSIQVEQSTISTM 342
Cdd:cd15208  159 WSDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVV------------QRKWNKPRKSAVAAEEKQL 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILF----WIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15208  227 RSRRKTAKMLIVVVIMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFlfshWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
115-415 1.22e-33

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 127.41  E-value: 1.22e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd14970    8 SVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICsgWYTTTENYkylKSNPHICEFK------- 267
Cdd:cd14970   87 IFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWAL-SLVLGLPVI--IFARTLQE---EGGTISCNLQwpdppdy 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSSSMSFWIPGIVMLSMYYRIYQeadrqerlvyrskvaalllekHLQISQIPKPRPSIQVEqstistmRRERK 347
Cdd:cd14970  161 WGRVFTIYTFVLGFAVPLLVITVCYSLIIR---------------------RLRSSRNLSTSGAREKR-------RARRK 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 348 AARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWI--GYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14970  213 VTRLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETLTVVGVFLFCIalSYANSCLNPILYAFLDENFRKSF 282
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
112-415 2.91e-33

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 126.64  E-value: 2.91e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVAL-CAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd14997    5 VVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLvCMPVALVETWAREPWLLGEFMCKLVPFVELTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICsgWYTTTENYKYLKSNP-HICEFKVN 269
Cdd:cd14997   85 AHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLL-ALLTSSPVL--FITEFKEEDFNDGTPvAVCRTPAD 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 ----KAYAIVSSSMSFWIPGIVMLSMYYRIYQeadrqeRLVYRSKVaalllekhlqisqipkprPSIQVEQSTISTMRRE 345
Cdd:cd14997  162 tfwkVAYILSTIVVFFVVPLAILSGLYSVICR------RLVGHPAL------------------ESRRADAANRHTLRSR 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 346 RKAARTLGIIMSAFLICWLPF---FLWYIVSSLCDSCITPRLLVGILFWIG----YFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14997  218 RQVVYMLITVVVLFFVCLLPFrvvTLWIIFAPDEDLQALGLEGYLNLLVFCrvmvYLNSALNPILYNLMSTKFRSAF 294
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
113-415 4.06e-33

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 125.86  E-value: 4.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15095    6 IFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQ 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSgWYTTTENYKYlkSNPHICE-----FK 267
Cdd:cd15095   86 ATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLS-IPVAI-YYRLEEGYWY--GPQTYCRevwpsKA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqERLVYRSKVAALllekhlqisqipkprpsiQVEQSTISTMRRERK 347
Cdd:cd15095  162 FQKAYMIYTVLLTYVIPLAIIAVCYGLIL------RRLWRRSVDGNN------------------QSEQLSERALRQKRK 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 348 AARTLGIIMSAFLICWLP---FFLWYIVSslcDSCITPRLLVGILFW---IGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15095  218 VTRMVIVVVVLFAICWLPnhvLNLWQRFD---PNFPETYATYALKIAalcLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
111-415 6.43e-33

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 125.93  E-value: 6.43e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGK-WMFGSVMCDMWNSFDVY 189
Cdd:cd14979    4 TAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYpWAFGDGGCKLYYFLFEA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTTENYKY--LKSNPHIC--- 264
Cdd:cd14979   84 CTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCA-IPILFLMGIQYLNGPLpgPVPDSAVCtlv 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 EFKVNKAYAI-VSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyRSKVAALLLEKHLQISQIPKPRpsiqveQSTISTMR 343
Cdd:cd14979  163 VDRSTFKYVFqVSTFIFFVLPMFVISILYFRI------------GVKLRSMRNIKKGTRAQGTRNV------ELSLSQQA 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 344 ReRKAARTLGIIMSAFLICWLPFFLWYI--------VSSLCDSCITPRLLVGILFwigYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14979  225 R-RQVVKMLGAVVIAFFVCWLPFHAQRLmfsyaskeDTFLFDFYQYLYPISGILF---YLSSAINPILYNLMSSRFRVAF 300
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
111-414 1.66e-32

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 124.09  E-value: 1.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15012    3 IILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSF-LPICSGWYTTTENYKYLKSNPH--ICEFK 267
Cdd:cd15012   83 YTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTpYFVFSQTVEILVTQDGQEEEICvlDREMF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSSSMSFWIPGIVMLSMYYRiyqeadrqerlvyrskvaalllekhlqisqipkprpsIQVEQSTISTMRRERK 347
Cdd:cd15012  163 NSKLYDTINFIVWYLIPLLIMTVLYSK-------------------------------------ISIVLWKSSSIEARRK 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 348 AARTLGIIMSAFLICWLPFFLWYIVSS-----LCDSCITpRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15012  206 VVRLLVAVVVSFALCNLPYHARKMWQYwsepyRCDSNWN-ALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
117-415 6.16e-31

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 120.43  E-value: 6.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFnaSVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15068   10 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITISTGFCAACHGCLFIACFVLVLTQSSIF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTT---TENYKYLKSNPH---ICEFKvnk 270
Cdd:cd15068   88 SLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPML-GWNNCgqpKEGKNHSQGCGEgqvACLFE--- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 aYAIVSSSMSFW-------IPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlQISQIPKPrpsiqvEQSTISTMR 343
Cdd:cd15068  164 -DVVPMNYMVYFnffacvlVPLLLMLGVYLRIFLAARRQLK----------------QMESQPLP------GERARSTLQ 220
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 344 RERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGIL-FWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15068  221 KEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLaIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
112-415 2.93e-30

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 118.17  E-value: 2.93e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlSPALLSFLPI--CSGWYttteNYKYLKSNPHICEFKVN 269
Cdd:cd15096   85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIW-IVILVANIPVlfLHGVV----SYGFSSEAYSYCTFLTE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFW-----IPGIVMLSMYyriyqeadrqerlvyrskvaaLLLEKHLQISQIPKPRPSIQveqstisTMRR 344
Cdd:cd15096  160 VGTAAQTFFTSFFlfsylIPLTLICVLY---------------------MLMLRRLRRQKSPGGRRSAE-------SQRG 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 345 ERKAARTLGIIMSAFLICWLPFFLWYIVSSLC-DSCITPRLLVGILF-WIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15096  212 KRRVTRLVVVVVVVFAICWLPIHIILLLKYYGvLPETVLYVVIQILSnCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
111-412 1.44e-28

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 113.95  E-value: 1.44e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIilaailGN--MLVIVSVMRHRKLRIItNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15382   10 LFLIAAV------GNltVLLILLRNRRRKRSRV-NILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 Y-FSTASIMhLCCISVDRYYAIVQPLDypLIMTQRRVFIMLLMVWL------SPALLSFL----PiCSGWYTTTENYKYL 257
Cdd:cd15382   83 FgLYLSSFV-LVCISLDRYFAILKPLR--LSDARRRGRIMLAVAWVisflcsIPQSFIFHveshP-CVTWFSQCVTFNFF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 258 KSNPHicEFkvnkAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALllekhlqisqipkprPSIQVEQS 337
Cdd:cd15382  159 PSHDH--EL----AYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSEKS---------------SSVRLRRS 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 338 TISTMRRERKaaRTLG---IIMSAFLICWLPFF---LWYIVSSLCDSCITPRLLVGiLFWIGYFNSALNPIIYAYFNRDF 411
Cdd:cd15382  218 SVGLLERARS--RTLKmtiVIVLVFIICWTPYFimsLWYWFDRESASKVDPRIQKG-LFLFAVSNSCMNPIVYGYFSIDL 294

                 .
gi 281362294 412 R 412
Cdd:cd15382  295 R 295
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
109-412 4.31e-28

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 112.49  E-value: 4.31e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWN---S 185
Cdd:cd15195    2 VRVLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMflkQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 186 FDVYFSTASIMhlcCISVDRYYAIVQPLDYPliMTQRRVFIMLLMVWLSPALLSflpICSGWYTTTENYKYLKSNPHIC- 264
Cdd:cd15195   82 FGMYLSSFMLV---VIALDRVFAILSPLSAN--QARKRVKIMLTVAWVLSALCS---IPQSFIFSVLRKMPEQPGFHQCv 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 ------EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyRSKVAALLLEKHLQISQIPKPRpsiqveqst 338
Cdd:cd15195  154 dfgsapTKKQERLYYFFTMILSFVIPLIITVTCYLLILFEISKMAK---RARDTPISNRRRSRTNSLERAR--------- 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 339 istmrreRKAARTLGIIMSAFLICWLPF---FLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15195  222 -------MRTLRMTALIVLTFIVCWGPYyvlGLWYWFDKESIKNL-PPALSHIMFLLGYLNPCLHPIIYGVFMKEIR 290
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
116-415 7.02e-28

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 111.68  E-value: 7.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNA-SVMISGKWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd15392    9 TIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFiALLILQYWPFGEFMCPVVNYLQAVSVFVS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPliMTQRRVFIMLLMVWLSpALLSFLPICsgWYTTTENYKYLKSNPHIC-----EFKVN 269
Cdd:cd15392   89 AFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIF-ALATALPIA--ITSRLFEDSNASCGQYICteswpSDTNR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllekhlqISQIPKPRPSIQVEQSTISTMRR-ERKA 348
Cdd:cd15392  164 YIYSLVLMILQYFVPLAVLVFTYTRI--------------------------GIVVWAKRTPGEAENNRDQRMAEsKRKL 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILF---WIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15392  218 VKMMITVVAIFALCWLPLNILNLVGDHDESIYSWPYIPYLWLaahWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
113-414 9.47e-28

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 111.27  E-value: 9.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVAL--CAMTFNASvmISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15083    6 FILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCIlnCPLMVISS--FSGRWIFGKTGCDMYGFSGGLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGW-------YTTTENYKYLKSNPhi 263
Cdd:cd15083   84 GIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLF-GWsryvlegLLTSCSFDYLSRDD-- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 264 cefkVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyrsKVAALLLEKHLQISQIPKPRPsiqveqstistmR 343
Cdd:cd15083  161 ----ANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEK-----AMKEMAKRFSKSELSSPKARR------------Q 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 344 RERKAARTLGIIMSAFLICWLPfflwYIVSSLCDSCITPRLLVGI-LFWIGYFNSA---LNPIIYAYFNRDFRAA 414
Cdd:cd15083  220 AEVKTAKIALLLVLLFCLAWTP----YAVVALIGQFGYLEVLTPLaTAIPAAFAKTsaiYNPVIYAFSHPKFRRA 290
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
113-415 1.47e-27

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 110.27  E-value: 1.47e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15296    6 LMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLI--MTQRRVFIMlLMVWLSPALLSFLPICSGWYTTTENykYLKSNPHICEFKVNK 270
Cdd:cd15296   86 ASVFNIVLISYDRFLSVTRAVSYRAQkgMTRQAVLKM-VLVWVLAFLLYGPAIISWEYIAGGS--IIPEGECYAEFFYNW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYQEADRqerlvyrskvaallleKHLQISqipkprpsiqveqstistmrRERKAAR 350
Cdd:cd15296  163 YFLMTASTLEFFTPFISVTYFNLSIYLNIQK----------------RRFRLS--------------------RDKKVAK 206
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15296  207 SLAIIVCVFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
112-414 1.67e-27

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 110.58  E-value: 1.67e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILA----AILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFD 187
Cdd:cd15336    1 YTVGSVILIigitGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGW-------YTTTENYKYLKSN 260
Cdd:cd15336   81 ALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLY-SLAWSLPPLFGWsayvpegLLTSCTWDYMTFT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 261 PhicefkVNKAYAIVSSSMSFWIPGIVMLSMYYRIY---QEADRQ-ERLVYRSKvaalllekhlqisqipkpRPSIQVEQ 336
Cdd:cd15336  160 P------SVRAYTMLLFCFVFFIPLGIIIYCYLFIFlaiRSTGREvQKLGSQDR------------------KEKAKQYQ 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 337 StistMRRERKAARTLGIIMSAFLICWLPFflwyivsslcdSCITprllvgILFWIGYFN----------------SAL- 399
Cdd:cd15336  216 R----MKNEWKMAKIAFVVILLFVLSWSPY-----------ACVA------LIAWAGYAHlltpymksvpaviakaSAIy 274
                        330
                 ....*....|....*
gi 281362294 400 NPIIYAYFNRDFRAA 414
Cdd:cd15336  275 NPIIYAITHPKYREA 289
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
117-415 2.82e-27

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 109.29  E-value: 2.82e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15001    9 TFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFlPICSGwyTTTENYKYLKSNP-HICE-----FKVNK 270
Cdd:cd15001   89 TLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILAS-PVLFG--QGLVRYESENGVTvYHCQkawpsTLYSR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMlsmyyriyqeadrqerlvyrskvaalllekhlqisqipkprpsiqveqsTISTMRRERKAA- 349
Cdd:cd15001  166 LYVVYLAIVIFFIPLIVM-------------------------------------------------TFAYARDTRKQVi 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSCITP----RLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15001  197 KMLISVVVLFAVCWGPLLIDNLLVSFDVISTLHtqalKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
114-415 6.87e-27

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 108.95  E-value: 6.87e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 114 IGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMlvALCA------MTFNAsvmISGKWMFGSVMCDMWNSFD 187
Cdd:cd15337    7 IAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDF--GFSAvngfplKTISS---FNKKWIWGKVACELYGFAG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGW-------YTTTENYKYLKSN 260
Cdd:cd15337   82 GIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFF-GWgryvpegFQTSCTFDYLSRD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 261 PHicefkvNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaallleKHLQISQIPKPRPSIQVEQSTis 340
Cdd:cd15337  161 LN------NRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEK-------------EMTQTAKSGMGKDTEKNDARK-- 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 341 tmRRERKAARTLGIIMSAFLICWLPfflwYIVSSLCDscitprlLVGILFWIGYFNSAL-----------NPIIYAYFNR 409
Cdd:cd15337  220 --KAEIRIAKVAIILISLFLLSWTP----YAVVALLG-------QFGPAYWITPYVSELpvmfakasaiyNPIIYALSHP 286

                 ....*.
gi 281362294 410 DFRAAF 415
Cdd:cd15337  287 KFRAAL 292
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
114-412 1.30e-26

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 108.23  E-value: 1.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 114 IGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTA 193
Cdd:cd14986    7 LGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 194 SIMHLCCISVDRYYAIVQPLDYplIMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTTenykyLKSNPHICEFKVN---- 269
Cdd:cd14986   87 STYILVSMSLDRYQAIVKPMSS--LKPRKRARLMIVVAWVLSFLFS-IPQLVIFVERE-----LGDGVHQCWSSFYtpwq 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 -KAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQisqipkprPSIQVEQSTIStmRRERKA 348
Cdd:cd14986  159 rKVYITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRPIAPTAMSCRSV--------SCVSSRVSLIS--RAKIKT 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd14986  229 IKMTLVIILAFILCWTPYFIVQLLDVYAGMQQLENDAYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
117-415 1.72e-26

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 108.10  E-value: 1.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAA--ILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSvmCDMWNSFDVYFSTAS 194
Cdd:cd15069    8 LIIAAlsVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHS--CLFLACFVLVLTQSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYT------TTENYKYLKSNPHICEFKV 268
Cdd:cd15069   86 IFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFL-GWNKamsatnNSTNPADHGTNHSCCLISC 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFW-------IPGIVMLSMYYRIYQEADRQerlvyrskvaalllekhLQisqipkprpSIQVEQSTIST 341
Cdd:cd15069  165 LFENVVPMSYMVYFnffgcvlPPLLIMLVIYIKIFLVACRQ-----------------LQ---------RTELMDHSRTT 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 342 MRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCD--SCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15069  219 LQREIHAAKSLAIIVGIFALCWLPVHILNCITLFQPefSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
115-415 3.77e-26

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 106.94  E-value: 3.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd16003    8 GFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMllMVWLSPALLSFlPICsgWYTTTenykylKSNPH--IC------EF 266
Cdd:cd16003   88 IYSMTAIAVDRYMAIIDPLKPRLSATATKVVIG--SIWILAFLLAF-PQC--LYSKT------KVMPGrtLCfvawpgGP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrskvaaLLLEKHLQISQIPKPRPSIQVEQstistMRRER 346
Cdd:cd16003  157 DQHFTYHIIVIVLVYCLPLLVMGITY---------------------TIVGITLWGGEIPGDTSDKYHEQ-----LRAKR 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 347 KAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGI---LFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd16003  211 KVVKMMIIVVLTFAICWLPYHIYFIVTGLYQQLNRWKYIQQVylaSFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
117-415 7.13e-26

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 105.55  E-value: 7.13e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15206   10 IFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVSTF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspaLLSFlpICSGWYTTTENYKYL-KSNPHICEFK-----VNK 270
Cdd:cd15206   90 TLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIW----LLSF--LIMSPILVFSNLIPMsRPGGHKCREVwpneiAEQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaaLLLEKhlqisqipkprpsiqveqstistmrreRKAAR 350
Cdd:cd15206  164 AWYVFLDLMLLVIPGLVMSVAYGLISWT---------------LLEAK---------------------------KRVIR 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 351 TLGIIMSAFLICWLPFFL---WYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15206  202 MLFVIVVEFFICWTPLYVintWKAFDPPSAARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
108-415 7.48e-26

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 106.01  E-value: 7.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFD 187
Cdd:cd14971    1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSgWYTTTEnykYLKSNPHICEF- 266
Cdd:cd14971   81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVA-APVLA-LHRLRN---YTPGNRTVCSEa 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 ----KVNKAYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqeRLVYRSKVAALLLEKhlqisqipkprpsiqveqstisTM 342
Cdd:cd14971  156 wpsrAHRRAFALCTFLFGYLLPLLLICVCYAAML-------RHLWRVAVRPVLSEG----------------------SR 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITP-----RLLVGILfwiGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14971  207 RAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGPFPLTYatyalRIWAHCL---AYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
115-415 1.07e-25

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 105.67  E-value: 1.07e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd15202    8 SFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDyPLImTQRRVFIMLLMVWLSPALLSF-LPICSGWYTTTENYKYLKSNPHIC----EFKVN 269
Cdd:cd15202   88 AYTLTAIAVDRYQAIMHPLK-PRI-SKTKAKFIIAVIWTLALAFALpHAICSKLETFKYSEDIVRSLCLEDwperADLFW 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllEKHLQISQIPKPRPSIQVEQstisTMRRERKAA 349
Cdd:cd15202  166 KYYDLALFILQYFLPLLVISFAYARV---------------------GIKLWASNMPGDATTERYFA----LRRKKKKVI 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIV-SSLCDSCITPRLLVGILF-WIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15202  221 KMLMVVVVLFALCWLPFNIYVLLlSSKPDYLIKTINAVYFAFhWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
116-415 1.13e-25

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 105.70  E-value: 1.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd16004    9 LIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLlmVWLSPALLSFlPICsgWYTTTENY----KYLKSNPHICEFKVNKA 271
Cdd:cd16004   89 YSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAG--IWLVALALAF-PQC--FYSTVTMDqgrtKCIVAWPGDSGGKHQLT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIyqeadrqERLVYRSKVaalllekhlqisqipkprPSIQVEQSTISTMRRERKAART 351
Cdd:cd16004  164 YHLAVIVLIYLLPLAVMFVTYSII-------GITLWRSAV------------------PGHQAHGAYHRQLQAKKKFVKT 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGI---LFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd16004  219 MVVVVVTFAICWLPYHLYFILGSFNEDIYCQKYIQQVylaIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
111-415 1.88e-25

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 104.80  E-value: 1.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15393    4 SILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPliMTQRRVFIMLLMVWLSpALLSFLPICSGWYT-----TTENYKYLKSNPHICE 265
Cdd:cd15393   84 VNVSVFTLTVIAVDRYRAVIHPLKAR--CSKKSAKIIILIIWIL-ALLVALPVALALRVeeltdKTNNGVKPFCLPVGPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 FKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhLQISQIPKPRPSIQVEQSTIstMRRE 345
Cdd:cd15393  161 DDWWKIYNLYLVCVQYFVPLVIICYAYTRIA-----------------------VKIWGTKAPGNAQDVRDDEI--LKNK 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 346 RKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILF---WIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15393  216 KKVIKMLIIVVALFALCWLPLQTYNLLNEIKPEINKYKYINIIWFcshWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
112-419 2.23e-25

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 104.14  E-value: 2.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15295    5 FLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQ-RRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKylksnphiCE--FKV 268
Cdd:cd15295   85 TASVYNIVLISYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGE--------CEpeFFS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPgiVMLSMYYRIYqeadrqerlVYRSkvaallLEKHLqisqipkprpsiqveqstistmrRERKA 348
Cdd:cd15295  157 NWYILAITSVLEFLVP--VILVAYFNTQ---------IYWS------LWKRL-----------------------RDRKL 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDSCiTPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTL 419
Cdd:cd15295  197 AKSLAIILGTFAICWAPYSLFTIIRAACEKH-RGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
111-414 2.37e-25

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 103.98  E-value: 2.37e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15213    4 AILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYpliMTQRRVFIMLLMVWLSPALLSFlPICSGWYTTTENYKYLKSNPHICEFKVNK 270
Cdd:cd15213   84 VLEGVAILLIISVDRYLIIVQRQDK---LNPHRAKILIAVSWVLSFCVSF-PPLVGWGKYEFPPRAPQCVLGYTESPADR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllekhlqisqipkprpsiqveqstISTMRR-ERKAA 349
Cdd:cd15213  160 IYVVLLLVAVFFIPFLIMLYSYFCI-------------------------------------------LNTVRSfKTRAF 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15213  197 TTILILFIGFSVCWLPYTVYSLLSVFSRYSSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFREA 261
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
107-415 3.06e-25

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 103.91  E-value: 3.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGFIILAailgNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSF 186
Cdd:cd14972    2 LVVAIVLGVFIVVE----NSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFsTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHIcef 266
Cdd:cd14972   78 VLSL-LASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDQESCSPLGPGL--- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 kvNKAYAIVsSSMSFWIPGIVMLSMYYRIYQEADRQErlvyrSKVAAlllekhLQISQIPKPRpsiqveqstistmRRER 346
Cdd:cd14972  154 --PKSYLVL-ILVFFFIALVIIVFLYVRIFWCLWRHA-----NAIAA------RQEAAVPAQP-------------STSR 206
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 347 KAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14972  207 KLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
111-415 4.22e-24

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 101.13  E-value: 4.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIgFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15402    5 CILI-FTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspaLLSFLPICSGWYTTTENYkylksNPHI--CEF-- 266
Cdd:cd15402   84 VIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIW----VLTVAAIVPNLFVGSLQY-----DPRIysCTFaq 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskVAALLLEKHLQISQIPKPRPsiqveqstistmrRER 346
Cdd:cd15402  155 SVSSAYTIAVVFFHFILPIIIVTFCYLRIW--------------ILVIQVRRRVKPDNKPKLKP-------------HDF 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 347 KAARTLGIIMSAFLICWLPF-FLWYIVSSLCDSCI--TPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15402  208 RNFVTMFVVFVLFAVCWAPLnFIGLAVAVDPETIVprIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
117-412 8.40e-24

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 100.24  E-value: 8.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFnaSVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15070   10 IGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPL--AIVVSLGVTIHFYSCLFMSCLLVVFTHASIM 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIcSGWYTTTeNYKYLKSNPHICEFK-VNKAYAIV 275
Cdd:cd15070   88 SLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPM-FGWNRKP-SLESVNTTPLQCQFTsVMRMDYMV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 276 SSSMSFW--IPGIVMLSMYYRIYQeadrqerlVYRSKVAAlllekhlqisqipkprpSIQVEQSTISTMRRERKAARTLG 353
Cdd:cd15070  166 YFSFFTWilIPLVIMCALYVDIFY--------IIRNKLSQ-----------------NATGFRETGAFYGREFKTAKSLA 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 354 IIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILfwIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15070  221 LVLFLFAVCWLPLSIINCVVYFNPKVPKIALYLGIL--LSHANSMMNPIVYACKIKKFK 277
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
112-415 1.06e-23

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 99.84  E-value: 1.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISgKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15093    5 CIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALR-HWPFGSVLCRLVLSVDGINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYTTTENYKYLKSNPHICEFKV--N 269
Cdd:cd15093   84 FTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVA-SLLVILPVVVFAGTRENQDGSSACNMQWPEPAAawS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlVYRSKVAALllekhlqisqipkpRPSIQVEQstistmRRERKAA 349
Cdd:cd15093  163 AGFIIYTFVLGFLLPLLIICLCYLLI----------VIKVKSAGL--------------RAGWQQRK------RSERKVT 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPrLLVGILFWI---GYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15093  213 RMVVMVVVVFVICWLPFYVLQLVNVFVQLPETP-ALVGVYHFVvilSYANSCANPILYGFLSDNFKKSF 280
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
112-408 1.48e-23

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 99.04  E-value: 1.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd14964    3 IILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTENYKYLKSNPHICefkVNKA 271
Cdd:cd14964   83 LASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLV-GKGAIPRYNTLTGSCYLIC---TTIY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSkvaalllekhlqisqipkprpsiqveQSTISTmrRERKAART 351
Cdd:cd14964  159 LTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSA--------------------------ASLNTD--KNLKATKS 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFN 408
Cdd:cd14964  211 LLILVITFLLCWLPFSIVFILHALVAAGQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
117-415 1.85e-23

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 99.38  E-value: 1.85e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd14985   10 IFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNMFASIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYAIVS 276
Cdd:cd14985   90 LLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKTACIMLYPHEAWHFGLSLEL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 277 SSMSFWIPGIVMLSMYYRIYQEADRQErlvyrskvaalllekhlqiSQIPKPRpsiqveqstistmRRERKAARTLGIIM 356
Cdd:cd14985  170 NILGFVLPLLIILTCYFHIARSLRKRY-------------------ERTGKNG-------------RKRRKSLKIIFALV 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 357 SAFLICWLPF----FLwYIVSSL-----CDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14985  218 VAFLVCWLPFhffkFL-DFLAQLgairpCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
111-415 2.48e-23

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 98.89  E-value: 2.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGkWMFGSVMCDMWNSF-DVY 189
Cdd:cd15178    4 CVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFAL-TLPFWAVSVVKG-WIFGTFMCKLVSLLqEAN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTaSIMHLCCISVDRYYAIVQPLDyplIMTQRR--VFIMLLMVWLSPALLS---------FLPICSGWYTTTENYkylk 258
Cdd:cd15178   82 FYS-GILLLACISVDRYLAIVHATR---ALTQKRhlVKFVCAGVWLLSLLLSlpallnrdaFKPPNSGRTVCYENL---- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 259 SNPHICEFKVnkAYAIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrSKVAALLLEKHlqisqipkprpsiqveqst 338
Cdd:cd15178  154 GNESADKWRV--VLRILRHTLGFLLPLVVMLFCY----------------GFTIKTLLQTR------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 339 istMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLC------DSCITPRLLVGILFW---IGYFNSALNPIIYAYFNR 409
Cdd:cd15178  197 ---SFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMrtklitETCELRNHVDVALYVtqiLGFLHSCINPVLYAFIGQ 273

                 ....*.
gi 281362294 410 DFRAAF 415
Cdd:cd15178  274 KFRNNL 279
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
116-413 2.59e-23

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 99.13  E-value: 2.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAaILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15391   10 TIFLS-VGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPliMTQRRVFIMLLMVWLSPALLSFLPICSGwytTTENYKYLKSNPHIC------EFKVN 269
Cdd:cd15391   89 LTNTAIGIDRFFAVIFPLRSR--HTKSRTKCIIASIWAISFSLSSVQLFAG---RTQRYGQYSEGRVLCgeswpgPDTSR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrQERLVYRSkvaalllekhlqisqipKPRPSIQVEQStiSTMRRERKAA 349
Cdd:cd15391  164 SAYTVFVMLLTYIIPLLILTSTYGYV------GFRLWNRT-----------------APGNADKGRDD--MQIKSKRKVI 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSCI-----TPRLLVGILFWIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd15391  219 KMLVFVVLMFGICWLPLHLFNLVQDFSTVFRnmpqhTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFRS 287
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
112-405 2.76e-23

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 98.80  E-value: 2.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCA--MTFNAsvmISGKWMFGSVMCDMWNSFDVY 189
Cdd:cd15079    5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMpiFIYNS---FYEGWALGPLGCQIYAFLGSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTASIMHLCCISVDRYYAIVQPLDyPLIMTQRRVFIMLLMVWLSPALLSFLPICSGW-------YTTTENYKYLKSNPH 262
Cdd:cd15079   82 SGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALLPLLFGWgryvpegFLTSCSFDYLTRDWN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 icefkvNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskVAALLLEKHLQISQIPKPRPSIQVEQSTISTM 342
Cdd:cd15079  161 ------TRSFVATIFVFAYVIPLIIIIYCYSFI---------------VKAVFAHEKALREQAKKMNVVSLRSNADANKQ 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPFFlwyIVSSLC----DSCITPrlLVGIL-FWIGYFNSALNPIIYA 405
Cdd:cd15079  220 SAEIRIAKVALTNVFLWFIAWTPYA---VVALIGafgnQSLLTP--LVSMIpALFAKTAACYNPIVYA 282
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
109-415 2.91e-23

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 98.38  E-value: 2.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15215    1 IRSVLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIcSGWYTTTENYKYlksnpHICE--F 266
Cdd:cd15215   81 LFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPL-YGWGQAAFDERN-----ALCSviW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLvyrskvaalllekhlqisqipkprpsiqveqstistmrrer 346
Cdd:cd15215  155 GSSYSYTILSVVSSFVLPVIIMLACYSMVFRAARRCYHC----------------------------------------- 193
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 347 KAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15215  194 KAAKVIFIIIFSYVLSMGPYSFLSVLAVWVDTQV-PQWVISIILWLFFLQCCIHPYIYGYMHKSIKKEF 261
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
117-408 4.06e-23

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 98.30  E-value: 4.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGK-WMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15212   10 IFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPgWLFGDRLCLANGFFNACFGIVST 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIV-QPLDYPLimtQRRVFIMLLMVWLSPALLS---FLPICSGWYTTTENYKYLKSNPHICEFKVNKA 271
Cdd:cd15212   90 LTMTLISFDRYYAIVrQPQGKIG---RRRALQLLAAAWLTALGFSlpwYLLASAPEYYEKLGFYHCLYVLHSGPSRLGAA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQEAdrqerlvyrskvaalllekHLQISQIpkpRPSiqveqSTISTMRR---ERKA 348
Cdd:cd15212  167 YSSVLIVLCYLLPFALMCFCHYNICKTV-------------------RLSESRV---RPV-----TTYAHLLRfysEMRT 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPrLLVGILFWIGYFNSALNPIIYAYFN 408
Cdd:cd15212  220 ATTVLIMIVFIICCWGPYCLLGLVAAAGGYQFPP-LMDTVAIWMAWANGAINPLIYAIRN 278
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
108-412 4.28e-23

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 98.31  E-value: 4.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIgFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMwNSFD 187
Cdd:cd15209    2 ALACVLI-VTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQA-SGFI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFST-ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspaLLSFLPICSGWYTTTENYkylksNPHI--C 264
Cdd:cd15209   80 MGLSViGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTW----LLTVLAVLPNFFIGSLQY-----DPRIysC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 EFK--VNKAYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskVAALLLEKHLQISQIPKPRPSiqveqstistm 342
Cdd:cd15209  151 TFAqtVSTVYTITVVVIHFLLPLLIVSFCYLRIW--------------VLVLQVRQRVKPDQRPKLKPA----------- 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 343 rrERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGIL---FWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15209  206 --DVRNFLTMFVVFVLFAVCWAPLNFIGLAVAINPKEMAPKIPEWLFvasYFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
113-402 5.65e-23

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 98.11  E-value: 5.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15927    6 LFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSG----WYTTTENYKYLKSNPHICEFKV 268
Cdd:cd15927   86 VSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLA-IPEAIFshvvTFTLTDNQTIQICYPYPQELGP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 N--KAYAIVSSSMSFWIPgIVMLSMYYriyqeadrqerlvyrskvaaLLLEKHLQIS--QIPKPRPSIQVEQstistMRR 344
Cdd:cd15927  165 NypKIMVLLRFLVYYLIP-LLIIGVFY--------------------VLMARHLIRStrNIGSGQNQAAQRQ-----IEA 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 345 ERKAARTLGIIMSAFLICWLP---FFLWYIVSSlcDSCITPRLLVGIL----FWIGYFNSALNPI 402
Cdd:cd15927  219 RKKVAKTVLAFVVLFAVCWLPrhvFMLWFHFAP--NGLVDYNAFWHVLkivgFCLSFINSCVNPV 281
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
113-412 6.82e-23

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 97.52  E-value: 6.82e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADmLVALCAMTFNA-SVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15088    6 VFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVAD-LLFMLGMPFLIhQFAIDGQWYFGEVMCKIITALDANNQ 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspaLLSFLPICSGW-YTTTENYkylKSNPHICEFKVNK 270
Cdd:cd15088   85 FTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLW----AASFLSILPVWvYSSLIYF---PDGTTFCYVSLPS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 A-----YAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlqisqipkprpsiQVEQSTIStmRRE 345
Cdd:cd15088  158 PddlywFTIYHFILGFAVPLVVITVCYILILHRLARGVA----------------------------PGNQSHGS--SRT 207
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 346 RKAARTLGIIMSAFLICWLPFFLWYIVsSLCDSCITPRLLVGILFWI--GYFNSALNPIIYAYFNRDFR 412
Cdd:cd15088  208 KRVTKMVILIVVVFIVCWLPFHVVQLV-NLAMNRPTLAFEVAYFLSIclGYANSCLNPFVYILVSENFR 275
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
109-415 1.10e-22

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 96.81  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15979    2 VRILLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLsFLPICSgwYTTTENYKYLKSNP-HICEF- 266
Cdd:cd15979   82 VSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLI-MIPYPV--YSVTVPVPVGDRPRgHQCRHa 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 ----KVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlVYRSKVAalllekhlqisqipkprpsiqveqstistm 342
Cdd:cd15979  159 wpsaQVRQAWYVLLLLILFFIPGVVMIVAYGLISRE-------LYRGLLA------------------------------ 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 343 rrERKAARTLGIIMSAFLICWLPFFL---WYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15979  202 --KKRVIRMLVVIVAMFFLCWLPIFSantWRAFDPLSAHRALSGAPISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
116-415 1.59e-22

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 96.72  E-value: 1.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd14977    9 VIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGVTV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYTTTENYkYLKSNPHICEFKVNKAYAIV 275
Cdd:cd14977   89 FSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVG-SVLLAVPEAVLSTVARESS-LDNSSLTVCIMKPSTPFAET 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 276 SSSMSFW--------IPGIVMLSMYYRIYQEADRQERLVYRSkvaallLEKHLQisqipkprpsiqveqstistmrRERK 347
Cdd:cd14977  167 YPKARSWwlfgcyfcLPLAFTAVCYLLMARTLIRAAKEYTRG------TKKHMK----------------------QRRQ 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 348 AARTLGIIMSAFLICWLPFFLWYIV------SSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14977  219 LAKTVLCLVLVFAFCWLPEHISNILratlynEVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
117-408 2.27e-22

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 96.19  E-value: 2.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNAS--VMISGKWMFGSVMCDMWN---SFDVYFS 191
Cdd:cd15204   10 IMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDyyVVRQRSWTHGDVLCAVVNylrTVSLYVS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASimhLCCISVDRYYAIVQPLDYPliMTQRRVFIMLLMVWLSPALLSflpICSGWYTTTENYKYLKSNphIC------- 264
Cdd:cd15204   90 TNA---LLVIAIDRYLVIVHPLKPR--MKRRTACVVIALVWVVSLLLA---IPSAVYSKTTPYANQGKI--FCgqiwpvd 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQeadrqeRLVYRskvaalllekhlqisQIPKprpsiQVEQSTISTMRR 344
Cdd:cd15204  160 QQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVR------KVWFR---------------RVPG-----QQTEQIRRRLRR 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 345 ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWI----GYFNSALNPIIYAYFN 408
Cdd:cd15204  214 RRRKVRLLVVILTAFVLCWAPYYGYAIVRDFFPTLLSKEKLNTTIFYIvealAMSNSMINTVVYVAFN 281
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
113-415 3.08e-22

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 95.95  E-value: 3.08e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKL--RIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15098    6 VFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICsgwYTTTENYKYLKSNPHIC-----E 265
Cdd:cd15098   86 MLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVL-SLAMASPVA---VHQDLVHHWTASNQTFCwenwpE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 FKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaallleKHLQISQIPKPRPSIqveqstistmRRE 345
Cdd:cd15098  162 KQQKPVYVVCTFVFGYLLPLLLITFCYAKVL---------------------NHLHKKLKNMSKKSE----------RSK 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 346 RKAARTLGIIMSAFLICWLP---FFLW--YIVSSLCDSCITPRLLVGILfwiGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15098  211 KKTAQTVLVVVVVFGISWLPhhiIHLWveFGDFPLTQASFVLRITAHCL---AYANSCVNPIIYAFLSENFRKAY 282
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
112-414 4.00e-22

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 95.57  E-value: 4.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIilaAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15073    8 IVAGII---STISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPlDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGW---------YTTTENYKylksnph 262
Cdd:cd15073   85 MASIGLLTVVAVDRYLTICRP-DLGRKMTTNTYTVMILLAWTNAFFWAAMPLV-GWasyaldptgATCTINWR------- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 iCEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQeadrqerlvyrskvaalllekhlQISQIPKPRPSIQV-----EQS 337
Cdd:cd15073  156 -KNDSSFVSYTMSVIVVNFIVPLAVMFYCYYNVSR-----------------------FVKKVLASDCLESVnidwtDQN 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 338 TISTMRRerkaartlgIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15073  212 DVTKMSV---------IMIVMFLVAWSPYSIVCLWASFGEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRRA 279
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
115-415 4.22e-22

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 95.62  E-value: 4.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd15094    8 GLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECF-LIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLsFLPIC--SGWYTTTENYKYLKSNPHICEFKVNKAY 272
Cdd:cd15094   87 SFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLV-MLPIIlyASTVPDSGRYSCTIVWPDSSAVNGQKAF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYriyqeadrqeRLVYRSKVAAlllekhlqisqiPKPRPSIQveqstistMRRERKAARTL 352
Cdd:cd15094  166 TLYTFLLGFAIPLLLISVFYT----------LVILRLRTVG------------PKNKSKEK--------RRSHRKVTRLV 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 353 GIIMSAFLICWLPFFLWYI-VSSLCDSCITPRLLVGILFWIG---YFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15094  216 LTVISVYIICWLPYWAFQVhLIFLPPGTDMPKWEILMFLLLTvlsYANSMVNPLLYAFLSENFRKSF 282
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
104-415 4.72e-22

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 95.70  E-value: 4.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 104 LALVFVKCFIIGFIilaailGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISG-KWMFGSVMCDM 182
Cdd:cd15357    3 MSLVYAVIFVVGVI------GNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNyPFLFGPVGCYF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 183 WNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPicsgwYTTTENYK--YLKSN 260
Cdd:cd15357   77 KTALFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFS-IP-----NTSIHGIKlqYFPNG 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 261 PHICEFkvnkayAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerLVYRSKVAALLLEKHLQIsqipKPRPSIQVEQSTIS 340
Cdd:cd15357  151 TLIPDS------ATCTVVKPLWIYNLIIQITSLLFY--------VLPMGVISVLYYLMGLKL----RGDKSLEADEMNVN 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 341 TMRRERKA-ARTLGIIMSAFLICWLPF-----FLWYIV---SSLCDSCITPRLLVGILFwigYFNSALNPIIYAYFNRDF 411
Cdd:cd15357  213 IQRPSRKSvTKMLFVLVLVFAICWAPFhvdrlFFSFVVewtEPLANVFNLIHVVSGVFF---YLSSAVNPIIYNLLSRRF 289

                 ....
gi 281362294 412 RAAF 415
Cdd:cd15357  290 RTAF 293
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
112-412 4.77e-22

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 95.29  E-value: 4.77e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15008    4 LVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLimTQRRVFIMLLMVWLSPALlsFLPICSGWYTTTENykylksnpHICEFKV--- 268
Cdd:cd15008   84 GVQIYVLLSICVDRFYTIVYPLSFKV--SREKAKKMIAASWLFDAA--FVSPALFFYGSNWG--------PHCNFFLpds 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 --NKAYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqeRLVYRSKVAALLLEKHLQIsqIPkprpsiqveqstistmRRER 346
Cdd:cd15008  152 wdGAAYAIIHLLVGFLVPSILIILFYQKVI-------KYIWRIGTDGRTVRRTMNI--VP----------------RTKV 206
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 347 KAARTLGIIMSAFLICWLPFF---LWYIVSSLCDSCitpRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15008  207 KTIKMFLMLNSMFLLSWLPFYvvqLWHPRESDYRQS---SLVFLAVTWISFSSSASKPTLYSVYNANFR 272
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
112-412 6.01e-22

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 94.97  E-value: 6.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIilaailGNMLVIVSVMRHRKLRIITNYFVVSLAVADmLVALCAMTFNASVMISGkWMFGSVMCDMWNSFdvyFS 191
Cdd:cd14984   11 FLLGLV------GNSLVLLVLLYYRKLRSMTDVYLLNLALAD-LLFVLTLPFWAVYAADG-WVFGSFLCKLVSAL---YT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 T---ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIcsgWYTTTENykylKSNPHICEFKV 268
Cdd:cd14984   80 InfySGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEF---IFSQVSE----ENGSSICSYDY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYA--------IVSSSMSFWIPGIVMLSMYYRIYQEADRqerlvyrskvaalllekhlqisqipkprpsiqveqstiS 340
Cdd:cd14984  153 PEDTAttwktllrLLQNILGFLLPLLVMLFCYSRIIRTLLR--------------------------------------A 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 341 TMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSL------CDSC-ITPRLLVGILF--WIGYFNSALNPIIYAYFNRDF 411
Cdd:cd14984  195 RNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLqllgiiSRSCeLSKSLDYALQVteSLAFSHCCLNPVLYAFVGVKF 274

                 .
gi 281362294 412 R 412
Cdd:cd14984  275 R 275
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
117-414 8.90e-22

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 94.48  E-value: 8.90e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15928   10 LMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYASIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspaLLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYA--- 273
Cdd:cd15928   90 HITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIW----AVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVSSgll 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 274 ---IVSSSMSFWIPgIVMLSMYYRiyqeadrqerlvyrskvaalLLEKHLQISQIPKPRPSIQVEQstistmRRERKAAR 350
Cdd:cd15928  166 svmLWVSTSFFFVP-MVCLSLLYG--------------------LIGRALWDRRQRSRTAGASRRD------NNHRQTVR 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSS--------LCDSCITPRLLVGILFwigYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15928  219 MLAVIVLAFVLCWLPFHVGRVIFNhsrastkhLHYVSQYFNLVSFVLF---YLSAAINPILYNLMSKRYRYA 287
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
116-415 2.82e-21

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 93.05  E-value: 2.82e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15401    9 FTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspaLLSFLPICSGWYTTTenykyLKSNPHI--CEF--KVNKA 271
Cdd:cd15401   89 FNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTW----VLTLAAIVPNFFVGS-----LQYDPRIysCTFaqTVSSS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQeadrqerLVyrskvaalllekhlqisqipkprpsIQVEQSTISTMRRERKAAR- 350
Cdd:cd15401  160 YTITVVVVHFIVPLSIVTFCYLRIWV-------LV-------------------------IQVKHRVRQDSKQKLKANDi 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 351 ----TLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRL---LVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15401  208 rnflTMFVVFVLFAVCWGPLNFIGLAVAINPLKVAPKIpewLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
117-415 3.64e-21

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 92.71  E-value: 3.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVAlCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15091   10 VFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVT-TTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTEN--------------YKYLKSNPH 262
Cdd:cd15091   89 TLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDvdstecslqfpdddYSWWDTFMK 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 ICEFkvnkayaivssSMSFWIPGIVMLSMYyriyqeadrqERLVYRSKvaalllekhlqisqipkprpSIQVEQSTISTM 342
Cdd:cd15091  169 ICVF-----------IFAFVIPVLIIIVCY----------TLMILRLK--------------------SVRLLSGSREKD 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWI--GYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15091  208 RNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFCIalGYTNSSLNPILYAFLDENFKRCF 282
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
108-413 4.64e-21

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 92.50  E-value: 4.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFiiGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNAS-VMISGKWMFGSVMCDMWNSF 186
Cdd:cd15394    3 IIPLY--SLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAyAFEPRGWVFGRFMCYFVFLM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLdyplimtQRRVFI-----MLLMVWLSPALLSfLPicsgwytTTENYKYLKSNP 261
Cdd:cd15394   81 QPVTVYVSVFTLTAIAVDRYYVTVYPL-------RRRISRrtcayIVAAIWLLSCGLA-LP-------AAAHTYYVEFKG 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 262 H---ICE------FKVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllEKHLQISQIPKPRPSI 332
Cdd:cd15394  146 LdfsICEefwfgqEKQRLAYACSTLLITYVLPLLAISLSYLRI---------------------SVKLRNRVVPGSMTQS 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 333 QVEQSTistmRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPR--LLVGIL-FWIGYFNSALNPIIYAYFNR 409
Cdd:cd15394  205 QAEWDR----ARRRKTFRLLVVVVVAFAICWLPLHIFNVIRDIDIDLIDKQyfNLIQLLcHWLAMSSACYNPFLYAWLHD 280

                 ....
gi 281362294 410 DFRA 413
Cdd:cd15394  281 SFRG 284
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
117-415 5.38e-21

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 92.60  E-value: 5.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSvmCDMWNSFDVYFSTASIM 196
Cdd:cd15071   10 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYS--CLMVACPVLILTQSSIL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGW-----YTTTENYKYLKSNPHI-CEF-KVN 269
Cdd:cd15071   88 ALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMF-GWnnlnaVERAWAANSSMGELVIkCQFeTVI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWI--PGIVMLSMYYRIYQEADRQerlvYRSKVAALLLEKHlqisqipkprpsiqveqstiSTMRRERK 347
Cdd:cd15071  167 SMEYMVYFNFFVWVlpPLLLMLLIYLEVFYLIRKQ----LNKKVSSSSSDPQ--------------------KYYGKELK 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 348 AARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15071  223 IAKSLALILFLFALSWLPLHILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
119-412 5.91e-21

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 91.74  E-value: 5.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 119 LAAILGNMLVIVSVMRHRKLRIITnyFVVSLAVADMLVALCAMTFNasvMISGKWMFGSVM-----CDMWNSFDVYFSTA 193
Cdd:cd15220   11 LTALVGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLG---ILSSSPFFLGVVfgeaeCRVYIFLSVCLVSA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 194 SIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTENYKYLKSNPHICEFKVN--KA 271
Cdd:cd15220   86 SILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVL-GWPSYGGPAPIAARHCSLHWSHSGhrGV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQeadrqerlVYRSKvaalllekhlqisqipkprpsiqveqstistmrrerKAART 351
Cdd:cd15220  165 FVVLFALVCFLLPLLLILVVYCGVFK--------VFGGG------------------------------------KAALT 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15220  201 LAAIVGQFLCCWLPYFAFHLYSALAASPVSGGEAEEVVTWLAYSCFAVNPFFYGLLNRQIR 261
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
117-415 9.50e-21

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 91.82  E-value: 9.50e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISG-KWMFGSVMCdmwnsfdvYFST--- 192
Cdd:cd15133   10 IFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNyPFLLGSGGC--------YFKTflf 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 -----ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspallSFLPICSGWYTTTENYKYLKSNPH---IC 264
Cdd:cd15133   82 etvclASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVW------GVSMLCALPNTSLHGIKFLGSGVPasaQC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 efKVNKAYAI------VSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHlQISQIPkprpsiqveqst 338
Cdd:cd15133  156 --TVRKPQAIynmipqHTGHLFFVLPMAVISVLYLLMALRLARERGLDATGAGSKIGTRTG-QLLQHP------------ 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 339 istmRRERKAARTLGIIMSAFLICWLPF----FLWYIVSSLCDSCITPRLLV----GILFWIGyfnSALNPIIYAYFNRD 410
Cdd:cd15133  221 ----RTRAQVTKMLFILVVVFAICWAPFhidrLMWSFISDWTDNLHEVFQYVhiisGVFFYLS---SAVNPILYNLMSTR 293

                 ....*
gi 281362294 411 FRAAF 415
Cdd:cd15133  294 FREMF 298
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
109-415 9.53e-21

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 91.47  E-value: 9.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15978    2 VRILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVW-LSPALLSFLPICSGWYTTTenyKYLKSNPHICEF- 266
Cdd:cd15978   82 ISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWcLSFTIMLPYPIYSNLVPFT---RINNSTGNMCRLl 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 ----KVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlVYRSkvaalllekhlqisqipkprpsiqveqstISTM 342
Cdd:cd15978  159 wpndVTQQSWYIFLLLILFLIPGIVMMTAYGLISLE-------LYRG-----------------------------IKFL 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPFFL---WYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15978  203 MAKKRVIRMLIVIVILFFLCWTPIFSanaWRAFDTRSADRLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
117-415 1.32e-20

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 91.08  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd16002   10 IVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASIY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLlmVWLSPALLSFlpiCSGWYTTTENYK----YLKSNPHICEFKVNKAY 272
Cdd:cd16002   90 SMTAIALDRYMAIIHPLQPRLSATATKVVICV--IWVLAFLLAF---PQGYYSDTEEMPgrvvCYVEWPEHEERKYETVY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrskvaaLLLEKHLQISQIPKPRPSIQVEQSTistmrRERKAARTL 352
Cdd:cd16002  165 HVCVTVLIYFLPLLVIGCAY---------------------TVVGITLWASEIPGDSSDRYHEQVS-----AKRKVVKMM 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGI---LFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd16002  219 IVVVCTFAICWLPYHIYFLLQYFHPELYEQKFIQQVylaIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
116-415 1.46e-20

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 91.42  E-value: 1.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVAL-CAMTFNASVMISGkWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd15981    9 FIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIfCMPTTLVDNLITG-WPFDNAMCKMSGLVQGMSVSAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPLimTQRRVFIMLLMVWLSpALLSFLPICSGWYTTTENY-----KYLKSNP-HIC---- 264
Cdd:cd15981   88 VFTLVAIAVERFRCIVHPFRQKL--TLRKAIVTIVIIWVL-ALIIMCPSAVTLTVTREEHhfmvdDYNNSYPlYSCweaw 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 -EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqERLVYRSKVAAlllekhlqisqipkpRPSIQVEQSTISTMR 343
Cdd:cd15981  165 pDTEMRKIYTTVLFSHIYLAPLTLIVIMYARI-------AFKLFKSSAPI---------------RGSQGEEEEGRRVSK 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 344 RERKAARTLGIIMSAFLICWLPffLWYIVsSLCD----SCITPRLLVGILF----WIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15981  223 RKIKVINMLIIVALFFTLSWLP--LWTLM-LLTDyghlSEDQLNLVTVYVFpfahWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
119-415 1.55e-20

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 91.28  E-value: 1.55e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 119 LAAILGNMLVIVSVMRHRKLRII-TNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMH 197
Cdd:cd15383   12 VLSACSNLAVLWSATRNRRRKLShVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSAFV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 198 LCCISVDRYYAIVQPLDypLIMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTT----ENYKYLKSNPHICEFKVNKAYA 273
Cdd:cd15383   92 TVVISLDRHAAILNPLA--IGSARRRNRIMLCAAWGLSALLA-LPQLFLFHTVTatppVNFTQCATHGSFPAHWQETLYN 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 274 IVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLekHLQISQIPKPRpsiqveqstistmrrerkaARTLG 353
Cdd:cd15383  169 MFTFFCLFLLPLLIMIFCYTRILLEISRRMKEKKDSAKNEVAL--RSSSDNIPKAR-------------------MRTLK 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 354 ---IIMSAFLICWLPFFL---WYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15383  228 mtiVIVSSFIVCWTPYYLlglWYWFSPEMLEQTVPESLSHILFLFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
112-415 2.40e-20

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 90.72  E-value: 2.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGF--IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVY 189
Cdd:cd15980    3 FIASYllIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVwLSPALLSflPICSGWYTTTENYKYL------KSNP-H 262
Cdd:cd15980   83 SVSASVFTLVAIAVDRFRCIVYPFKQKLTISTAVVIIVIIWV-LAIAIMC--PSAVMLHVQEEKNYRVvlgsqnKTSPvY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 ICEF-----KVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaALLLEKhlqiSQIPKPRPSIQVEQS 337
Cdd:cd15980  160 WCREdwpnqEMRKIYTTVLFANIYLAPLSLIVIMYARI-----------------GITLFK----TAMPHTGKHNQEQRH 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 338 TIStmRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILF-----WIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15980  219 VVS--RKKQKVIKMLLIVALLFILSWLPLWTLMMLSDYANLSPNQLQIINIYIypfahWLAFFNSSVNPIIYGFFNENFR 296

                 ...
gi 281362294 413 AAF 415
Cdd:cd15980  297 RGF 299
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
117-415 2.45e-20

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 90.39  E-value: 2.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLvALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15089   10 VCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFlPICSGWYTttenyKYLKSNPHICEFKV-------N 269
Cdd:cd15089   89 TLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGV-PIMVMAVT-----KTPRDGAVVCMLQFpspswywD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPgIVMLSMYYRIYQEADRQERLVYRSKvaalllEKHlqisqipkprpsiqveqstistmRRERKAA 349
Cdd:cd15089  163 TVTKICVFIFAFVVP-ILVITVCYGLMILRLRSVRLLSGSK------EKD-----------------------RNLRRIT 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDscITPRLLVGILFW-----IGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15089  213 RMVLVVVAAFIICWTPIHIFVIVWTLVD--IDRRNPLVVAALhlciaLGYANSSLNPVLYAFLDENFKRCF 281
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
116-414 3.72e-20

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 89.94  E-value: 3.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15131    9 LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYTTTENykylKSNPHICEFKVNKAYAIV 275
Cdd:cd15131   89 LNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAV-SFLSAGPIFVLVGVEHEN----GTNPIDTNECKATEYAVR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 276 S---------SSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlqisqipkprpsiqvEQSTISTMRRE- 345
Cdd:cd15131  164 SglltimvwvSSVFFFLPVFCLTVLYSLIGRKLWRRRR------------------------------ENIGPNASHRDk 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 346 --RKAARTLGIIMSAFLICWLPF---------------FLWYIVSSLCDscitprLLVGILFwigYFNSALNPIIYAYFN 408
Cdd:cd15131  214 nnRQTVKMLAVVVFAFVLCWLPFhvgrylfsksfeagsLEIALISQYCN------LVSFVLF---YLSAAINPILYNIMS 284

                 ....*.
gi 281362294 409 RDFRAA 414
Cdd:cd15131  285 KKYRVA 290
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
116-415 4.16e-20

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 89.53  E-value: 4.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMwNSFDVYFST-AS 194
Cdd:cd15400    9 FTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKV-SGFVMGLSViGS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspaLLSFLPICSGWYTTTenykyLKSNPHI--CEF--KVNK 270
Cdd:cd15400   88 IFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIW----ALTVVAIVPNFFVGS-----LEYDPRIysCTFvqTASS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskVAALLLEKHLQISQIPKPRPSiqveqstistmrrERKAAR 350
Cdd:cd15400  159 SYTIAVVVIHFIVPITVVSFCYLRIW--------------VLVIQVRRKVKSESKPRLKPS-------------DFRNFL 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRL---LVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15400  212 TMFVVFVIFAICWAPLNLIGLAVAINPQEMAPKVpewLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
115-414 4.28e-20

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 89.70  E-value: 4.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd15389    8 SIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDyPLIMTQRRVFIMlLMVWLSPALLSfLPicSGWYTTTENYKYLKSnphicefkVNKAYAI 274
Cdd:cd15389   88 TLTLTAIALDRHRVILHPLK-PRITPCQGVVVI-AIIWIMASCLS-LP--HAIYQKLVEFEYSNE--------RTRSRCL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 275 VS---SSMSFW-------------IPGIVMLSMYYRIYQeadrqeRLVYRSKVAALLLEKhlQISQIpkprpsiqveqst 338
Cdd:cd15389  155 PSfpePSDLFWkyldlatfilqyvLPLLIIGVAYTRVAK------KLWLRNAIGDVTTEQ--YVAQR------------- 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 339 istmRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDscITPRLLVGILF-WIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15389  214 ----RKKKKTIKMLMLVVLLFAICWLPLNCYHVLLSSHP--IRSNSALFFAFhWLAMSSTCYNPFIYCWLNDSFRSE 284
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
117-415 8.77e-20

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 88.77  E-value: 8.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15092   10 VCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspALLSFLPICSGWYTTTENykylKSNPHICEFKV-------N 269
Cdd:cd15092   89 TLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIW---ALASVVGVPVMVMGSAQV----EDEEIECLVEIptpqdywD 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPgIVMLSMYYRIYQEADRQERLVYRSKvaalllEKHlqisqipkprpsiqveqstistmRRERKAA 349
Cdd:cd15092  162 PVFGICVFLFSFIIP-VLIISVCYSLMIRRLRGVRLLSGSK------EKD-----------------------RNLRRIT 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWI--GYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15092  212 RLVLVVVAVFVGCWTPIQIFVLAQGLGVQPSSETAVAILRFCTalGYVNSSLNPVLYAFLDENFKACF 279
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
116-413 9.01e-20

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 88.86  E-value: 9.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCaMTFNASVMISGKWM-FGSVMCdMWNSFDVYFST-A 193
Cdd:cd14982    9 LIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLT-LPFRIYYYLNGGWWpFGDFLC-RLTGLLFYINMyG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 194 SIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL------SPALLSFLPIC--SGWYTTTENYKYLKSNPHIce 265
Cdd:cd14982   87 SILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWIlvlvasVPLLLLRSTIAkeNNSTTCFEFLSEWLASAAP-- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 fkvnkaYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqeRLVYRSKVAALLLekhlqisqipkprpsiqveqstistmRRE 345
Cdd:cd14982  165 ------IVLIALVVGFLIPLLIILVCYSLII-------RALRRRSKQSQKS--------------------------VRK 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 346 RKAARTLGIIMSAFLICWLPF----FLWYIV-SSLCDSCITPRLLVG---ILFWIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd14982  206 RKALRMILIVLAVFLVCFLPYhvtrILYLLVrLSFIADCSARNSLYKayrITLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
113-415 1.11e-19

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 88.64  E-value: 1.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15192    6 VYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICsgwyTTTENYKYLKSNPHICEFKVNK-- 270
Cdd:cd15192   86 ASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVAS-LPAI----IHRDVFFIENTNITVCAFHYPSqn 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 -----AYAIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrskvaALLLEKHLQISQIPKPRPsiqveqstistmrRE 345
Cdd:cd15192  161 stllvGLGLMKNLLGFLIPFLIILTCY--------------------TLIGKALKKAYEIQRNKP-------------RN 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 346 RKAARTLGIIMSAFLICWLP-----FFLWYIVSSLCDSCITPRLL---VGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15192  208 DEIFKMIMAVVLFFFFCWIPhqiftFLDVLIQLKVIQDCHIADIVdtaMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
112-415 1.24e-19

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 88.54  E-value: 1.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISG-KWMFGSVMCDMwNSFDVYF 190
Cdd:cd15134    5 IIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQyPWVFGEVFCKL-RAFLSEM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 ST-ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSgwYTTTENYKYLKSNPH------I 263
Cdd:cd15134   84 SSyASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWII-AFVCALPFAI--QTRIVYLEYPPTSGEaleesaF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 264 CEFKVNKAYAIVSSSMS----FWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllekHLQISQIPKPRPSIQVEQSTI 339
Cdd:cd15134  161 CAMLNEIPPITPVFQLStflfFIIPMIAIIVLYVLI-----------------------GLQLRRSTLLRRGQRSVSGGR 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 340 STMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVG-ILFWIG----YFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15134  218 RSSQSRRTVLRMLVAVVVAFFICWAPFHAQRLLTVYAKNMTPPYLFINrILFYISgvlyYVSSTVNPILYNVMSAKYRQA 297

                 .
gi 281362294 415 F 415
Cdd:cd15134  298 F 298
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
117-415 1.50e-19

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 87.71  E-value: 1.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15210   10 FMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTenykyLKSNPHICEF---KVNKAYA 273
Cdd:cd15210   90 TLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFG-----LDPKVCSCSIlrdKKGRSPK 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 274 IVSSSMSFWIPGIVMLSMYYRiyqeadrqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRERKAARTLG 353
Cdd:cd15210  165 TFLFVFGFVLPCLVIIICYAR------------------------------------------------REDRRLTRMML 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 354 IIMSAFLICWLPFFLWYIVsslcDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15210  197 VIFLCFLVCYLPITLVNVF----DDEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
104-414 1.51e-19

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 88.37  E-value: 1.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 104 LALVFVKCFIIGFiilaaiLGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMW 183
Cdd:cd15403    3 LAIVMILMIAIGF------LGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRIS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 184 NSFDVYFSTASIMHLCCISVDRYYAIVQPLDYpliMTQRRVFIMLLMVWLSPALLSFlPICSGWYTTTENYKYLKSNPHI 263
Cdd:cd15403   77 AMLYWFFVLEGVAILLIISVDRFLIIVQRQDK---LNPHRAKVMIAISWVLSFCISF-PSVVGWTLVEVPARAPQCVLGY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 264 CEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQE-RLVYRSKVAALLLEKHLQISQIPKPrPSIQVEqstistM 342
Cdd:cd15403  153 TESPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAvRIHNHADSLCLSQVSKLGLMGLQRP-HQMNVD------M 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPfflwYIVSSLCdSCITPRLLVGILF--------WIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15403  226 SFKTRAFTTILILFVGFSLCWLP----HTVFSLL-SVFSRRFYYSSSFypistcvlWLSYLKSVFNPVIYCWRIKKFREA 300
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
113-415 3.47e-19

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 87.16  E-value: 3.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAIL-GNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15974    5 VIYLLVCAIGLsGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFML-GLPFLATQNAISYWPFGSFLCRLVMTVDGVNQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSgwytttenYKYLKSNPHICEFK---- 267
Cdd:cd15974   84 FTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVV-LPVII--------FSDVQPDLNTCNISwpep 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 ---VNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlVYRSKVAALllekhlqisqipkprpsiqveqSTISTMRR 344
Cdd:cd15974  155 vsvWSTAFIIYTAVLGFFGPLLVICLCYLLI----------VIKVKSSGL----------------------RVGSTKRR 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 345 --ERKAARTLGIIMSAFLICWLPFFLWYIVSSlcdSCITPR--LLVGILFWI---GYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15974  203 ksERKVTRMVVIIVVVFVFCWLPFYMLNIVNL---IVILPEepAFVGVYFFVvvlSYANSCANPILYGFLSDNFKQSF 277
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
97-422 4.58e-19

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 87.53  E-value: 4.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294  97 DADGSSHLALVFVKCFIIGfiilaaILGNMLVIVsVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGKWMFG 176
Cdd:PHA03087  36 YDTNSTILIVVYSTIFFFG------LVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLFVM-TLPFQIYYYILFQWSFG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 177 SVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFlPI-----CSGWYTTT 251
Cdd:PHA03087 108 EFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETT-PIlfvytTKKDHETL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 252 ENYKYLKSNPHICEFKVNkayaIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhlqisqipkprps 331
Cdd:PHA03087 187 ICCMFYNNKTMNWKLFIN----FEINIIGMLIPLTILLYCYSKIL----------------------------------- 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 332 iqVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSL-----CDSCITPR---LLVGILFWIGYFNSALNPII 403
Cdd:PHA03087 228 --ITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLhilhfKSGCKAVKyiqYALHVTEIISLSHCCINPLI 305
                        330
                 ....*....|....*....
gi 281362294 404 YAYFNRDFRAAFKKTLKVS 422
Cdd:PHA03087 306 YAFVSEFFNKHKKKSLKLM 324
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
110-407 1.12e-18

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 85.95  E-value: 1.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 110 KCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVY 189
Cdd:cd15384    3 KIVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTASIMHLCCISVDRYYAIVQPLDYplIMTQRRVFIMLLMVWLSPALLS-------------FLPI---CSGWYTTTEN 253
Cdd:cd15384   83 GLYLSTYITVLISLDRCVAILYPMKR--NQAPERVRRMVTVAWILSPIFSipqavifhvergpFVEDfhqCVTYGFYTAE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 254 YKylksnphicefkvNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAAlllekhlqisqipkpRPSIQ 333
Cdd:cd15384  161 WQ-------------EQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLEIYT---------------RNRGP 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 334 VEQSTIStmRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYF 407
Cdd:cd15384  213 NRQRLFH--KAKVKSLRMSAVIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVIFFFGMSNSCVNPLIYGAF 284
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
112-415 1.49e-18

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 85.43  E-value: 1.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLvALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15090    5 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTTEN--YKYLKSNPHICEFKVN 269
Cdd:cd15090   84 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMATTKYRQgsIDCTLTFSHPSWYWEN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 kAYAIVSSSMSFWIPgIVMLSMYYRIYQEADRQERLVYRSKvaalllEKHlqisqipkprpsiqveqstistmRRERKAA 349
Cdd:cd15090  163 -LLKICVFIFAFIMP-VLIITVCYGLMILRLKSVRMLSGSK------EKD-----------------------RNLRRIT 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDsciTPRLLVGILFW-----IGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15090  212 RMVLVVVAVFIVCWTPIHIYVIIKALVT---IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
113-415 3.17e-18

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 84.48  E-value: 3.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRI---ITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVY 189
Cdd:cd15338    6 VFGVICFLGIIGNSIVIYTIVKKSKFRCqqtVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITALDTN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspaLLSFLPICSGWYTT--------TENYKYLKSNP 261
Cdd:cd15338   86 SQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVW----ILSLLSITPVWMYAglmplpdgSVGCALLLPNP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 262 HICEFkvnkAYAIVSSSMSFWIPGIVMLSMYYRIYQeadrqerlvyrskvaalllekHLQISQIPKPRPSIQVeqstist 341
Cdd:cd15338  162 ETDTY----WFTLYQFFLAFALPLVVICVVYFKILQ---------------------NMASTVAPLPQRSLRV------- 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 342 mrRERKAARTLGIIMSAFLICWLPFFLWYIVS-SLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15338  210 --RTKKVTRMAVAICLAFFICWAPFYILQLAHlSIDRPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
112-415 3.49e-18

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 84.42  E-value: 3.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFiilaaiLGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15191   11 FILGF------LGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLmVWLSpALLSFLPicSGWYTTTENYKYLKSNPHICEFKVNKA 271
Cdd:cd15191   85 FASIFFITCMSVDRYLAVVYPLRSQRRRSWQARLVCLL-VWVL-ACLSSLP--TFYFRDTYYIEELGVNACIMAFPNEKY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 Y------AIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaallleKHLQISQIPKprpsiqveqstiSTMRRE 345
Cdd:cd15191  161 AqwsaglALMKNTLGFLIPLIVIATCYFGIG---------------------RHLLKTKGFG------------KNKQRR 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 346 RKAARTLGIIMSAFLICWLPF----FL----WYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15191  208 DKVLKMVAAVVLAFLICWFPFhvltFLdalaRMGVINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
112-415 3.88e-18

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 83.81  E-value: 3.88e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15970    5 FIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLML-SVPFLVTSTLLRHWPFGSLLCRLVLSVDAINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYTTTENYKYLKSNPHICEFKVN-- 269
Cdd:cd15970   84 FTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVF-SILVILPIIIFSNTAPNSDGSVACNMQMPEPSQRwl 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlVYRSKVAALllekhlqisqipkpRPSIQVEQstistmRRERKAA 349
Cdd:cd15970  163 AVFVVYTFLMGFLLPVIAICLCYILI----------IVKMRVVAL--------------KAGWQQRK------RSERKIT 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILfwIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15970  213 LMVMMVVTVFVICWMPFYVVQLVSVFVGQHDATVSQLSVI--LGYANSCANPILYGFLSDNFKRSF 276
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
113-413 3.89e-18

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 84.03  E-value: 3.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVsVMRHRKLRIITNY-FVVSLAVADmLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd14999    5 VLSLMCVVGVAGNVYTLV-VMCLSMRPRASMYvYILNLALAD-LLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLmVWLSPALLSfLPICSGWYTTTENYKYLKSNPHICEF---KV 268
Cdd:cd14999   83 HASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLAGV-IWLLSLLLT-LPMAIMIRLVTVEDKSGGSKRICLPTwseES 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvYRSKVAALllekhlqisqipkprpsiqveqSTISTMRR-ERK 347
Cdd:cd14999  161 YKVYLTLLFSTSIVIPGLVIGYLYIRLARK--------YWLSQAAA----------------------SNSSRKRLpKQK 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 348 AARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFW----IGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd14999  211 VLKMIFTIVLVFWACFLPFWIWQLLYLYSPSLSLSPRTTTYVNYlltcLTYSNSCINPFLYTLLTKNYKE 280
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
113-413 4.21e-18

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 83.86  E-value: 4.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILA----AILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCdMWNSFDV 188
Cdd:cd15074    2 IIGIYLTVigilSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGC-VFYGFCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 Y-FSTASIMHLCCISVDRYYAIVQPLDYPLImTQRRVFIMLLMVWLSPALLSFLPIcSGW-YTTTENYkylksnPHICEF 266
Cdd:cd15074   81 FlFGCCSINTLTAISIYRYLKICHPPYGPKL-SRRHVCIVIVAIWLYALFWAVAPL-VGWgSYGPEPF------GTSCSI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIVsSSMSF---------WIPGIVMLSMYYRIYQEadrqerlvyrskvaalllekhlqisqIPKPRPSIQVEQS 337
Cdd:cd15074  153 DWTGASASV-GGMSYiisififcyLLPVLIIVFSYVKIIRK--------------------------VKSSRKRVAGFDS 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 338 TISTMRR-ERKAARTLGIIMSAFLICWLPfflwYIVSSLCDSCITPRLLVGILFWIGYF----NSALNPIIYAYFNRDFR 412
Cdd:cd15074  206 RSKRQHKiERKVTKVAVLICAGFLIAWTP----YAVVSMWSAFGSPDSVPILASILPALfaksSCMYNPIIYLLFSSKFR 281

                 .
gi 281362294 413 A 413
Cdd:cd15074  282 Q 282
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
117-415 4.78e-18

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 83.72  E-value: 4.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15399   10 IILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLimTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSnpHICEFKV---NKAYA 273
Cdd:cd15399   90 TLTVIALDRHRCIVYHLESKI--SKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKI--QACSEKWpngTLNDG 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 274 IVSSSMSFWIPGIVMLSM----YYRIYQEadrqerlvyrskvaallLEKHLQISqipkprpsiqveQSTISTMRRERKAA 349
Cdd:cd15399  166 TIYSVSMLLIQYVLPLAIisyaYIRIWTK-----------------LKNHVSPG------------GGNDHYHQRRRKTT 216
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLcDSCITP----RLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15399  217 KMLVCVVVVFAVSWLPFHAFQLASDI-DSKVLDlkeyKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
117-413 5.55e-18

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 83.65  E-value: 5.55e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15193   10 IFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNRCSSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspALLSFLPICSGWYTTTENYKYLKSNPhicEFKVNKAYAIVS 276
Cdd:cd15193   90 FLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIW---AVSLVLGIPSLVYRNLINESVCVEDS---SSRFFQGISLAT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 277 SSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaallleKHLQisqipkpRPSIQVEQstisTMRRERKAARTLGIIM 356
Cdd:cd15193  164 LFLTFVLPLIVILFCYCSIL---------------------VRLR-------RHFHGAKR----TGRRRRNSLRIVFAIV 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 357 SAFLICWLPFFLWYIVSSL---------CDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd15193  212 TAFVLSWLPFNTLKAVRLLlelgggvlpCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
112-415 5.58e-18

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 83.37  E-value: 5.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15973    5 FIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFML-SVPFLAASAALQHWPFGSAMCRTVLSVDGINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKA 271
Cdd:cd15973   84 FTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWIL-SLLVISPIIIFADTATRKGQAVACNLIWPHPAWSAA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrSKVAALLLEKHLQISQipkprpsiqveqstistmRRERKAART 351
Cdd:cd15973  163 FVIYTFLLGFLLPVLAIGLCYILII------------GKMRAVALKAGWQQRR------------------KSEKKITRM 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLC---DSCITPRLLVgilfwIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15973  213 VLMVVTVFVICWMPFYVVQLLNLFLprlDATVNHASLI-----LSYANSCANPILYGFLSDNFRRSF 274
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
108-415 6.29e-18

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 83.84  E-value: 6.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAAILGNMLVIVsVMRHRKLRIITNYFVVSLAVADMLVALCAMTFnaSVMISGKWMFGSVMCDMWNSFD 187
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALPL--FLLPYIADYSSSFLSYFYAYFL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VY-------FSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSF--------LPICSGWYTTTE 252
Cdd:cd14978   78 PYiyplantFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLprffeyevVECENCNNNSYY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 253 NYKYLKSNPHICEFKvnKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlqisqipKPRPSI 332
Cdd:cd14978  158 YVIPTLLRQNETYLL--KYYFWLYAIFVVLLPFILLLILNILLIRALRKSKK----------------------RRRLLR 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 333 QVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITP---RLLVGILFWIGYFNSALNPIIYAYFNR 409
Cdd:cd14978  214 RRRRLLSRSQRRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSpiyQLLGDISNLLVVLNSAVNFIIYCLFSS 293

                 ....*.
gi 281362294 410 DFRAAF 415
Cdd:cd14978  294 KFRRTF 299
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
108-415 7.17e-18

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 84.05  E-value: 7.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGK-WMFGSVMCDMWNSF 186
Cdd:cd15005    1 ALKLTTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGwytttENYKYLK-SNPHICE 265
Cdd:cd15005   81 AVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDV-----GTYTFIReEDQCTFE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 FKVNKAyaivSSSMSFwipgIVMLS--------MYYRIYQEADRQERLVYRSKVAAlllekhlqISQ------------- 324
Cdd:cd15005  156 HRSYKA----NDTLGF----MLVLAvviaathlVYLKLLIFLRHHRKMKPAQLVPA--------ISQnwtfhgpgatgqa 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 325 ----------IPKPRPSIQVEQSTISTMRR---------ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLL 385
Cdd:cd15005  220 aanwtagfgrGPTPPTLLGIRQAFHSGARRllvldefkmEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRGYAVPQGF 299
                        330       340       350
                 ....*....|....*....|....*....|
gi 281362294 386 VGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15005  300 LTAAVWMTFAQAGVNPIVCFFFNRELRKCL 329
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
122-415 1.07e-17

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 82.93  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 122 ILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCI 201
Cdd:cd15972   15 LGGNTLVIYVVLRYSASESVTNIYILNLALADELFML-GLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFTSIFCLTVM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 202 SVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS-----FLPICSGWYTTTENYKYLKSnphicefKVNKAYAIVS 276
Cdd:cd15972   94 SVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVlpvviFSGVPGGMGTCHIAWPEPAQ-------VWRAGFIIYT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 277 SSMSFWIPGIVMLSMYYRIYQEADRQERlvyrsKVAALllekhlqisqipkprpsiqveqstiSTMRR--ERKAARTLGI 354
Cdd:cd15972  167 ATLGFFCPLLVICLCYLLIVVKVRSSGR-----RVRAT-------------------------STKRRgsERKVTRMVVI 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 355 IMSAFLICWLPFFLWYIVSSLCDSCITPRLLvGILFWI---GYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15972  217 VVAAFVLCWLPFYALNIVNLVCPLPEEPSLF-GLYFFVvvlSYANSCANPIIYGFLSDNFKQGF 279
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
109-415 1.10e-17

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 82.43  E-value: 1.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGK--WMFGSVMCDMWNSF 186
Cdd:cd14995    2 VATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLGPdsWIYGYAGCLLITYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLsflpiCSGWYTTTEnYKYLKSNPHI--- 263
Cdd:cd14995   82 QYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLY-----CSPWLFLLD-LSIKHYGDDIvvr 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 264 CEFKVNKAYAIVSSSMSF----WIPGIVMLSMYYRIyqeadrqERLVYRSKVaalllekhlqisQIPKprpsiqveqsti 339
Cdd:cd14995  156 CGYKVSRHYYLPIYLADFvlfyVIPLLLAIVLYGLI-------GRILFSSRK------------QVTK------------ 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 340 stmrrerkaarTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14995  205 -----------MLAVVVVLFALLWMPYRTLVVYNSFASPPYLDLWFLLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
114-412 1.16e-17

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 82.29  E-value: 1.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 114 IGFIILA--AILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15214    4 IAIIIIAilICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYTTT-ENYKYLksnphicefkVNK 270
Cdd:cd15214   84 SASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLH-SLIGCLPPLFGWSSLEfDRFKWM----------CVA 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFW------IPGIVMLSMYYRIYqeadrqeRLVYRSKVAALLlekhlqisqipkprpsiqveqstistmrr 344
Cdd:cd15214  153 AWHKEAGYTAFWqvwcalLPFVVMLVCYGFIF-------RVARANQCKAFI----------------------------- 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 345 erkaarTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15214  197 ------TILVVLGAFVTTWGPYMVVISTEALWGKNSVSPQLETLATWLSFTSAVCHPLIYGLWNKTVR 258
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
117-414 1.17e-17

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 82.89  E-value: 1.17e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMR-HRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMwNSFDVYFST-AS 194
Cdd:cd15190   20 VFVLGLSGNGLVLWTVFRsKRKRRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKL-SSYLVFVNMyAS 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPIC---------SGWYTTTE-NYKYLKSNPHic 264
Cdd:cd15190   99 VFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLA-LPALilrttsdleGTNKVICDmDYSGVVSNES-- 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRskvaalllekhlqisqipkprpsiqveqstistmRR 344
Cdd:cd15190  176 EWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLRR----------------------------------KE 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 345 ERKAARTLGIIMS---AFLICWLPFFLWYIVSSLCD------SCITPRLLVGILFW---IGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15190  222 DKKKRRLLKIIITlvvTFALCWLPFHLVKTLYALMYlgilpfSCGFDLFLMNAHPYatcLAYVNSCLNPFLYAFFDPRFR 301

                 ..
gi 281362294 413 AA 414
Cdd:cd15190  302 QQ 303
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
117-415 2.25e-17

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 82.09  E-value: 2.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15000    9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLimTQRRVFIMLLMVWLSPALLSfLPIcsGWYTTTENYKYLKSNPHIC--EFKVNKAYAI 274
Cdd:cd15000   89 ALCAVSYDRLTAIVLPSEARL--TKRGAKIVIVITWIVGLLLA-LPL--AIYRSYRERQWKNFLETYCaeNTQVLPIYWH 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 275 VSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSkvaalllEKHLQIsqipkprpsiqveqstistmRRERKAARTLGI 354
Cdd:cd15000  164 VIITVLVWLPLGIMLICYSAIFWKLDKYERRVLRR-------EHPSVV--------------------RYKKKAAKTLFI 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 355 IMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYF--------NSALNPIIYAYFNRDFRAAF 415
Cdd:cd15000  217 VLITFVVCRIPFTALIFYRYKLVPNDNTQNSVSGSFHILWFaskylmflNAAVNPLIYGFTNENFRKAF 285
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
113-424 2.42e-17

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 81.83  E-value: 2.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15084   16 LMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPL-DYPLimtQRRVFIM-------LLMVWLSPALL---SFLPICSG------WYTTTENyk 255
Cdd:cd15084   96 VGLWSLAILAFERYLVICKPMgDFRF---QQRHAVSgcaftwgWSLLWTSPPLFgwsSYVPEGLRtscgpnWYTGGTN-- 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 256 ylksnphicefkvNKAYAIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrskvAALLLEKHLQISQipkprpsiQVE 335
Cdd:cd15084  171 -------------NNSYILALFVTCFALPLSTIIFSY-------------------SNLLLTLRAVAAQ--------QKE 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 336 QSTisTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15084  211 SET--TQRAEKEVTRMVIAMVMAFLICWLPYATFAMVVATNKDVVIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCL 288

                 ....*....
gi 281362294 416 KKTLkvSCG 424
Cdd:cd15084  289 LELL--CCG 295
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
112-415 3.14e-17

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 81.43  E-value: 3.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15971    5 FIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFML-GLPFLAIQVALVHWPFGKAICRVVMTVDGINQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPIC--SGWYTTTENYKYLKSNPHICEfKVN 269
Cdd:cd15971   84 FTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGV-SLLVILPIMiyAGVQTKHGRSSCTIIWPGESS-AWY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllekhlqisqIPKPRPS-IQVEQStiSTMRRERKA 348
Cdd:cd15971  162 TGFIIYTFILGFFVPLTIICLCYLFI-----------------------------IIKVKSSgIRVGSS--KRKKSEKKV 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 349 ARTLGIIMSAFLICWLPFFLwYIVSSLCDSCITPRLLVGILFWI---GYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15971  211 TRMVSIVVAVFVFCWLPFYI-FNVSSVSVSISPTPGLKGMFDFVvvlSYANSCANPILYAFLSDNFKKSF 279
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
113-412 3.55e-17

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 81.40  E-value: 3.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKlRIITNYFVVSLAVADMlVALCAMTFNASVMI-SGKWMFGSVMCDMWNSFDV--Y 189
Cdd:cd15339    6 FIGILCSTGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADL-VHIIVMPFLIHQWArGGEWVFGSPLCTIITSLDTcnQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTASIMHLCCIsvDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpallSFLPICSGW-YTTTENYkylKSNPHICEFKV 268
Cdd:cd15339   84 FACSAIMTAMSL--DRYIALVHPFRLTSLRTRSKTIRINLLVWAA----SFILVLPVWvYAKVIKF---RDGLESCAFNL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKA-----YAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerLVYRSKVAALLLEKHLQISQIPKprpsiqveqstistmR 343
Cdd:cd15339  155 TSPddvlwYTLYQTITTFFFPLPLILICYILI---------LCYTWEMYRKNKKAGRYNTSIPR---------------Q 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 344 RERKAARTLGIIMSAFLICWLPFFLWYIVS-SLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15339  211 RVMRLTKMVLVLVGVFLVSAAPYHVIQLVNlSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFR 280
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
117-412 5.71e-17

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 80.94  E-value: 5.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15397   10 VMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTVSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDY-PLImtqRRVFIMLLMVWLSPALLSfLPICSGWYTTTENYKYLksnPHICEFKVNKAYAIV 275
Cdd:cd15397   90 SLVLIALERHQLIINPTGWkPSV---SQAYLAVVVIWMLACFIS-LPFLAFHILTDEPYKNL---SHFFAPLADKAVCTE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 276 SSS--------------MSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIpkprpsiqveqstist 341
Cdd:cd15397  163 SWPsehhklayttwlllFQYCLPLLFILVCYLRIYLRLRRRKDMLERRGEYNRRAGHSKRINVM---------------- 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 342 mrrerkaartLGIIMSAFLICWLPFFLWYIVSSLCDSCITP---RLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15397  227 ----------LVSLVAAFALCWLPLNVFNAIADWNHEAIPHcqhNLIFSLCHLAAMASTCVNPIIYGFLNSNFK 290
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
111-415 6.45e-17

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 80.97  E-value: 6.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISG-KWMFGSVMCdmwnsfdvY 189
Cdd:cd15358    4 CVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNyPFLLGAGGC--------Y 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FST--------ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICS--GWYTTTENYKYLKS 259
Cdd:cd15358   76 FKTllfetvcfASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVV-SILCSIPNTSlhGIFQLTVPCRGPVP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 260 NPHICEF-KVNKAYAIV---SSSMSFWIPGIVMLSMYYRIYQEADRQErlvyrskvaaLLLEKHLQISQIPKPRPSIQVE 335
Cdd:cd15358  155 DSATCMLvKPRWMYNLIiqiTTLLFFFLPMGTISVLYLLIGLQLKREK----------MLLVLEAKGSKAGDSYQHRRIQ 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 336 QSTistmRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLV--------GILFwigYFNSALNPIIYAYF 407
Cdd:cd15358  225 QEK----RRRRQVTKMLFVLVVVFGICWAPFHTDRLMWSFISQWTGELHLAfqyvhiisGVFF---YLSSAANPVLYNLM 297

                 ....*...
gi 281362294 408 NRDFRAAF 415
Cdd:cd15358  298 STRFREMF 305
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
112-414 8.51e-17

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 79.88  E-value: 8.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15404    5 AVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLFV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYpliMTQRRVFIMLLMVWLSPALLSF--------------LPICSGWYTTTENYkyl 257
Cdd:cd15404   85 MEGVAILLIISIDRFLIIVQKQDK---LNPYRAKVLIAVSWAVSFCVAFplavgspdlqipsrAPQCVFGYTTNPGY--- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 258 ksnphicefkvnKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllekhlqisqipkprpsiqveqs 337
Cdd:cd15404  159 ------------QAYVILIMLIFFFIPFMVMLYSFMGI------------------------------------------ 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 338 tISTMRR-ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGI---LFWIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd15404  185 -LNTVRSfKTRAFTTILILFIVFTVCWAPFTTYSLVATFNSHFYHKHNFFEIstwLLWLCYLKSALNPLIYYWRIKKFRD 263

                 .
gi 281362294 414 A 414
Cdd:cd15404  264 A 264
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
112-415 9.95e-17

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 80.05  E-value: 9.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMwNSFDVYFS 191
Cdd:cd15168    5 IVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKL-VRFLFYFN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 T-ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSgwYTTTENykylKSNPHIC------ 264
Cdd:cd15168   84 LyGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWIL-VLLQLLPILF--FATTGR----KNNRTTCydttsp 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 -EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqeRLVYRskvaalllekhlqisqipKPRPSIQVeqstistmR 343
Cdd:cd15168  157 eELNDYVIYSMVLTGLGFLLPLLIILACYGLIV-------RALIR------------------KLGEGVTS--------A 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 344 RERKAARTLGIIMSAFLICWLPFFLW---YIVSSLCDSCITPRLLVGI-LFWIG-----YFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15168  204 LRRKSIRLVIIVLALFAVCFLPFHVTrtiNLAARLLSGTASCATLNGIyVAYKVtrplaSLNSCLNPLLYFLAGDKFRRR 283

                 .
gi 281362294 415 F 415
Cdd:cd15168  284 L 284
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
113-415 1.27e-16

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 79.76  E-value: 1.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVM--RHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15002    5 LLGVICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHAC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLImTQRRVFIMLLMVWLSPALlsfLPICSGWYTT--TENYKYLKsnphICEFKV 268
Cdd:cd15002   85 MAAKSFTIAVLAKACYMYVVNPTKQVTI-KQRRITAVVASIWVPACL---LPLPQWLFRTvkQSEGVYLC----ILCIPP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NK-----AYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQerlvyRSKVAALLLEkhlqisqipkprpsiqveqstistmR 343
Cdd:cd15002  157 LAhefmsAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRR-----GTKTQNLRNQ-------------------------I 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 344 RERKAARTLGIIMSAFLICWLP-FFLWYIVSSLCDSCITPRLLVGILFWIGYF-NSALNPIIYAYFNRDFRAAF 415
Cdd:cd15002  207 RSRKLTHMLLSVVLAFTILWLPeWVAWLWLIHIKSSGSSPPQLFNVLAQLLAFsISSVNPIIFLLMSEEFREGF 280
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
114-415 1.27e-16

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 79.59  E-value: 1.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 114 IGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVS-LAVADMLVALC--------AMTFNASVMISGKWMfGSVMCDMWN 184
Cdd:cd14980    7 IWIIGILALIGNILVIIWHISSKKKKKKVPKLLIInLAIADFLMGIYlliiaiadQYYRGRYAQYSEEWL-RSPPCLLAC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 185 SFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLiMTQRRVFIMLLMVWLSPALLSFLPICS--GWYTTTENYKY----LK 258
Cdd:cd14980   86 FLVSLSSLMSVLMMLLITLDRYICIVYPFSNKR-LSYKSAKIILILGWLFSIIFAAIPILYsiNQPGDNRLYGYssicMP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 259 SNPHICEFKVNKAYAIVSSSMSFwipgIVMLSMYYRIYqeadrqeRLVYRSKVAAlllekhlqisqipkprpsiqveqsT 338
Cdd:cd14980  165 SNVSNPYYRGWLIAYLLLTFIAW----IIICILYILIF-------ISVRKSRKSA------------------------R 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 339 ISTMRRERKAARTLGIIMSAFLICWLPFFLwYIVSSLCDScitPRLLVGILFWIGYF----NSALNPIIYAYFNRDFRAA 414
Cdd:cd14980  210 RSSSKRDKRIAIRLALILITDLICWLPYYI-VIFSGLLTS---TEIDIHVLQFIAILalplNSAINPYLYTLTTPTFKRD 285

                 .
gi 281362294 415 F 415
Cdd:cd14980  286 F 286
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
115-415 1.72e-16

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 79.27  E-value: 1.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAILGNMLVIVsVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMwNSFDVYFST-A 193
Cdd:cd14974    8 ALIFLLGLPGNGLVIW-VAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKL-NSFVISLNMfA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 194 SIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPicSGWYTTTENYKylksNPHICEFKVNKAYA 273
Cdd:cd14974   86 SVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLS-VP--YFVFRDTVTHH----NGRSCNLTCVEDYD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 274 IVSSSMS----------FWIPGIVMLSMYYRIYQEADRqerlvyrskvaalllekhlqisqipkprpsiqveqstiSTMR 343
Cdd:cd14974  159 LRRSRHKaltvirflcgFLLPLLIIAICYSVIAVKLRR--------------------------------------KRLA 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 344 RERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIG--YFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14974  201 KSSKPLRVLLAVVVAFFLCWLPYHVFALLELVAAAGLPEVVLLGLPLATGlaYFNSCLNPILYVFMGQDFRKRL 274
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
112-415 2.41e-16

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 79.03  E-value: 2.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNAsVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15172    5 VIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVL-TLPFWA-VYEAHQWIFGNFSCKLLRGIYAINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVF--IMLLMVWLSPALLSFLPicsgwYTTTENYKYLKSNPHICEFKVN 269
Cdd:cd15172   83 YSGMLLLACISVDRYIAIVQATKSFRLRSRTLAYskLICAAVWLLAILISLPT-----FIFSEVYDFGLEEQYVCEPKYP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYA---------IVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskVAALLLEKHLQisqipkprpsiqveqstis 340
Cdd:cd15172  158 KNSTaimwkllvlSLQVSLGFFIPLLVMIFCYSFI---------------IKTLLQAQNSQ------------------- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 341 tmrrERKAARTLGIIMSAFLICWLPF--FLWYIVSSL-----CDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd15172  204 ----RHKAVRVVVAVVLVFLVCQVPYniVLLIEAINLgeqqsCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRN 279

                 ..
gi 281362294 414 AF 415
Cdd:cd15172  280 YF 281
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
106-415 7.76e-16

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 77.44  E-value: 7.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 106 LVFVKCFIIGFIIlaAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADM---LVALCAMTFNASvmiSGKWMFGSVMCDM 182
Cdd:cd15161    1 ILFALFYILVFIL--AFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLsyvLILPMRLVYHLS---GNHWPFGEVPCRL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 183 wNSFDVYFST-ASIMHLCCISVDRYYAIVQPLDYpliMTQRR-------VFIMLLMVWLSPALLSFLPICSGWYTTTENY 254
Cdd:cd15161   76 -AGFLFYLNMyASLYFLACISVDRFLAIVHPVKS---MKIRKplyahvvCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 255 K-YLKSNPHicefkvnkaYAIVSSSMSFWIPGIVMLSMYYriyqeadrqerLVYRSKVAALLLEKHLQisqipkprpsiq 333
Cdd:cd15161  152 QlYREKASR---------GALVSLAVAFTIPFVTTVTCYL-----------LIIRSLRTGKREEKPLK------------ 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 334 veqstistmrreRKAARTLGIIMSAFLICWLPFFL---WYIVSSLCD--SCITPRLLV---GILFWIGYFNSALNPIIYA 405
Cdd:cd15161  200 ------------DKAIKMIILVLTIFLICFVPYHIsryIYILSHNGAgaSCSSRRGLAlanRITSCLTCLNGALDPVMYF 267
                        330
                 ....*....|
gi 281362294 406 YFNRDFRAAF 415
Cdd:cd15161  268 FVAEKFRETL 277
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
107-414 9.83e-16

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 77.15  E-value: 9.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIgFIIlaAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSF 186
Cdd:cd15132    3 VTIVCLIL-FVV--GVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlSPALLSFLPICSGWYTTTENYKYLKSNPHICEF 266
Cdd:cd15132   80 SEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALW-AFALLSAGPFLFLVGVEQDNNIHPDDFSRECKH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 kvnKAYAIVS---------SSMSFWIPGIVMLSMYYRIYQEadrqerlVYRSKvaalllekhlqiSQIPKPrpsiqveqS 337
Cdd:cd15132  159 ---TPYAVSSgllgimiwvTTTYFFLPMLCLSFLYGFIGRK-------LWKSK------------NDLRGP--------N 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 338 TISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRL-----LVGILFWigYFNSALNPIIYAYFNRDFR 412
Cdd:cd15132  209 AAARERSHRQTVRILAVVVLAFIICWLPFHIGRILFANTEDYRTMMFsqyfnIVAMQLF--YLSASINPILYNLISRKYR 286

                 ..
gi 281362294 413 AA 414
Cdd:cd15132  287 AA 288
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
114-408 1.38e-15

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 76.77  E-value: 1.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 114 IGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFN-ASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15198    7 LGVILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQiIWELLGDRWMAGDVACRLLKLLQASARG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLimtqrRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICE--FKVN- 269
Cdd:cd15198   87 ASANLVVLLALDRHQAIRAPLGQPL-----RAWKLAALGWLLALLLALPQAYVFRVDFPDDPASAWPGHTLCRgiFAPLp 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 ----KAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyRSKVAALLLEkhlqisqipKPRPSIQVEQSTISTMRRE 345
Cdd:cd15198  162 rwhlQVYATYEAVVGFVAPVVILGVCYGRLLLKWWERAN---QAPGAKKPWK---------KPSKSHLRATAPSALPRAK 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 346 RKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFN 408
Cdd:cd15198  230 VKTLKMTLVIALLFVGCSLPYFIAELAAAFGSGDWEPEKVAAALGVMAVANSATNPFVFLFFN 292
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
113-415 1.42e-15

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 76.40  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKL-RIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15097    6 VFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFlPICSgwYTTTENYkylkSNPHIC----EFK 267
Cdd:cd15097   86 YASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAG-PYLS--YYDLIDY----ANSTVCmpgwEEA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaallleKHLQISQIPKPRPSiqveqstiSTMRRERK 347
Cdd:cd15097  159 RRKAMDTCTFAFGYLIPVLVVSLSYTRTI---------------------KYLWTAVDPLEAMS--------ESKRAKRK 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 348 AARTLGIIMSAFLICWLPFFL-----WYIVSSLCDSCITPRLLVGILfwiGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15097  210 VTKMIIIVTALFCLCWLPHHVvilcyLYGDFPFNQATYAFRLLSHCM---AYANSCLNPIVYALVSKHFRKGF 279
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
112-408 2.02e-15

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 76.31  E-value: 2.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAI-LGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15197    4 LATLWVLFVFIvVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYplIMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTTENYKYLKSNPHICEFKVNK 270
Cdd:cd15197   84 TYASTYVLVALSIDRYDAICHPMNF--SQSGRQARVLICVAWILSALFS-IPMLIIFEKTGLSNGEVQCWILWPEPWYWK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYqeadrqeRLVYRSKVAALLLEKHlqisQIPKPRPSIQVEQSTIStmRRERKAAR 350
Cdd:cd15197  161 VYMTIVAFLVFFIPATIISICYIIIV-------RTIWKKSKIQVTINKA----GLHDGSSRRSSSRGIIP--RAKIKTIK 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 351 TLGIIMSAFLICWLPFFLWYI--VSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFN 408
Cdd:cd15197  228 MTFVIVTVFIICWSPYFVFDLldVFGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCLFS 287
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
113-412 2.62e-15

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 75.58  E-value: 2.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNAsVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15179    6 VYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVL-TLPFWA-VDAAANWYFGNFLCKAVHVIYTVNLY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYpliMTQRRVF---IMLLMVWLsPALLSFLPICSGWYTTTENYKYL--KSNPHICEFK 267
Cdd:cd15179   84 SSVLILAFISLDRYLAIVHATNS---QRPRKLLaekVVYVGVWL-PALLLTVPDLVFAKVSELDDRYIcdRIYPEDTFEL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllekhlqISQIPKprpsiqveqstiSTMRRERK 347
Cdd:cd15179  160 WVVAFRFQHILVGLVLPGLVILTCYCII--------------------------ISKLSH------------SKGHQKRK 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 348 AARTLGIIMSAFLICWLP---------FFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15179  202 ALKTTVILILAFFACWLPyyigisidtFMLLEIIKQSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFK 275
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
111-412 3.29e-15

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 75.55  E-value: 3.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGfiilaaILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGkWMFGSVMCDMWNSFDVYF 190
Cdd:cd15176   10 ALVVG------LAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPFWAADAVNG-WVLGTAMCKITSALYTMN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRvfIMLLMVWLSPALLSfLP--ICSGWYTTTENYKYLKSNPHICEFKV 268
Cdd:cd15176   82 FSCGMQFLACISVDRYVAITKATSRQFTGKHCW--IVCLCVWLLAILLS-IPdlVFSTVRENSDRYRCLPVFPPSLVTSA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrSKVAALLLEkhlqisqipkprpsiqveqstiSTMRRERKA 348
Cdd:cd15176  159 KATIQILEVLLGFVLPFLVMVFCY----------------SRVARALSR----------------------TPNVKKSRA 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 349 ARTLGIIMSAFLICWLPFF---LW------YIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15176  201 LKVLLAVVGVFIVTQLPYNvvkFYraidviYLLITDCSMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
107-415 3.90e-15

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 75.26  E-value: 3.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGfiiLAAILGNMLVIVSVMRHRKLRIITNY-FVVSLAVADMLVA-LCAMTFNASVMISGK-------WMFGS 177
Cdd:cd15099    3 IAVLCFLAG---PVTFLENILVLLTILSSTALRRRPSYlFIGSLALADMLASvIFTISFLDFHVFHQRdsrnlflFKLGG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 178 VMCDMwnsfdvyfsTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTENYKYL 257
Cdd:cd15099   80 VTMAF---------TASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLM-GWRCKTWDSPCS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 258 KSNPHICEfkvnkayaivsSSMSFWIPGI-VMLSM----YYRIYQEADRQErlvyrskvaALLLEKHLQISQIPKPrpsi 332
Cdd:cd15099  150 RLFPYIDR-----------HYLASWTGLQlVLLFLiiyaYPYILWKAHRHE---------ANMGGPKLGRQQVKGQ---- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 333 qveqstiSTMRRERKAARTLGIIMSAFLICWLP---FFLWYIVSSLCDSCITPRLLVGILFWIgyfNSALNPIIYAYFNR 409
Cdd:cd15099  206 -------ARMRMDIRLAKTLSLILLVLAICWLPvlaFMLVDVRVTLTNKQKRMFAFCSMLCLV---NSCVNPIIYALRSR 275

                 ....*.
gi 281362294 410 DFRAAF 415
Cdd:cd15099  276 ELRGAM 281
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
107-415 4.03e-15

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 75.19  E-value: 4.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIiGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGkWMFGSVMCDMWNSF 186
Cdd:cd15173    1 YFLPCMY-SVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLF-LCTLPFWAYSAAHE-WIFGTVMCKITNGL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVF--IMLLMVWLSPALLSFLPICsgwYTTTENYKYLKSNPHIC 264
Cdd:cd15173   78 YTINLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWgkVVCTLVWVISLLLSLPQFI---YSEVRNLSSKICSMVYP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskVAALLLEKHLQisqipkprpsiqveqstistmrr 344
Cdd:cd15173  155 PDAIEVVVNIIQMTVGFFLPLLAMIICYSVI---------------IKTLLHAKGFQ----------------------- 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 345 ERKAARTLGIIMSAFLICWLPF---FLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15173  197 KHKSLKIIFVVVAVFILTQLPYnimKLIRTLHIENTDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
116-415 4.84e-15

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 75.22  E-value: 4.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILG-NMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd15082   21 FVVTSLSLAeNFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAVTFFGIVA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDyPLIMTQRRVFIMLLMVWLSPALLSFLPICsGW--YTTTENYKYLKSNPHICEFKvNKAY 272
Cdd:cd15082  101 LWSLAVLAFERFFVICRPLG-NIRLQGKHAALGLLFVWTFSFIWTIPPVL-GWssYTVSKIGTTCEPNWYSGNMH-DHTY 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRiyqeadrqerlvyrskvaalLLEKHLQISQIpkprpsiqveQSTISTMRR-ERKAART 351
Cdd:cd15082  178 IITFFTTCFILPLGVIFVSYGK--------------------LLQKLRKVSNT----------QGRLGNARKpERQVTRM 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15082  228 VVVMIVAFMVCWTPYAAFSILVTAHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
117-415 1.11e-14

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 74.19  E-value: 1.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15123   10 IISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLP--ICSGWYTTTE---NYKYLKSNPHICEFKVNKA 271
Cdd:cd15123   90 TLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFA-IPeaVFSDLYSFRDpekNTTFEACAPYPVSEKILQE 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYQeadrqeRLVYRSKVaALLLEKHLQISQipkprpsiQVEQstistmrrERKAART 351
Cdd:cd15123  169 IHSLLCFLVFYIIPLSIISVYYFLIA------RTLYKSTF-NMPAEEHSHARK--------QIES--------RKRVAKT 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLC-DSCITPRL--LVGILF--WIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15123  226 VLVLVALFAFCWLPNHILYLYRSFTyHTSVDSSAfhLIATIFsrVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
124-415 1.50e-14

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 73.62  E-value: 1.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 124 GNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISV 203
Cdd:cd15087   17 GNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTL-VLPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYFLTVMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 204 DRYY---AIVQPLDYPLiMTQRRVFIMLLMVWLSPALLsFLP--ICSGWYTTTENYK---YLKSNPHICEFKVNKAYAIV 275
Cdd:cd15087   96 DRYLvvlATVRSRRMPY-RTYRAAKIVSLCVWLLVTII-VLPftVFAGVYSNELGRKscvLSFPSPESLWFKASRIYTLV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 276 sssMSFWIPgivmLSMYYRIYQEADRQERLVyRSKVAALLLEKhlqisqiPKPRPSIQVEqstistmrrerkaartlgII 355
Cdd:cd15087  174 ---LGFAIP----VSTICILYTMMLYKLRNM-RLNSNAKALDK-------AKKKVTLMVL------------------VV 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 356 MSAFLICWLPFFLWYIVSSLCDSCITPrLLVGILFWI---GYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15087  221 LAVCLFCWTPFHLSTVVALTTDLPQTP-LVIGISYFItslSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
108-412 1.59e-14

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 74.21  E-value: 1.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADML-VALCAMTFNASVMISGKWMFGSVMCDMWNSF 186
Cdd:cd15217    1 YVKLVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIrSAVCFPFVLVSIRNGSAWTYSVLSCKIVAFM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSgwyttTENYKYLKSNPHiCEF 266
Cdd:cd15217   81 AVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFD-----VGTYKFIREEDQ-CIF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KvnKAYAIVSSSMSFWIPGIVMLSMYYRIYQE----ADRQERLVYRSKVAALLLEKHLQ---------------ISQIPK 327
Cdd:cd15217  155 E--HRYFKANDTLGFMLMLAVLIVATHIVYGKlllfEYRHRKMKPVQMVPAISQNWTFHgpgatgqaaanwiagFGRGPM 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 328 PRPSIQVEQSTISTMRR---------ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSA 398
Cdd:cd15217  233 PPTLLGIRQNAHTANRRllgmeefkaEKRLGRMFYVITLSFLVLWSPYIVACYWRVFVKACSIPHRYLSTAVWMSFAQAG 312
                        330
                 ....*....|....
gi 281362294 399 LNPIIYAYFNRDFR 412
Cdd:cd15217  313 VNPIVCFLLNKDLK 326
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
113-415 1.74e-14

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 73.40  E-value: 1.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15124    6 VYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSF----LPICSGWYTTTENYKYLKSNPHICEFKV 268
Cdd:cd15124   86 VSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIpeavFSDLHPFYDKSTNKTFVSCAPYPHSNEL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYriYQEADRQERLVYRSKVaalllEKHLQISQipkprpsiQVEQstistmrrERKA 348
Cdd:cd15124  166 HPKIHSMASFLIFYVIPLSIISVYY--YFIAKNLIRSAYNLPV-----EGNVHVRR--------QIES--------RKRL 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWI----GYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15124  223 AKTVLVFVGLFAFCWLPNHIIYLYRSYHYSEVDTSMLHFVSSICarilAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
116-412 1.91e-14

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 73.29  E-value: 1.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFG---SVMCDMWNSFDVYFST 192
Cdd:cd15351    9 FLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVcraPMLQHMDNVIDTMICS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 A---SIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsgwytttenykYLKSNphicefkvn 269
Cdd:cd15351   89 SvvsSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIV-----------YYNSN--------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 kayAIVSSSMSFWIPGIV-MLSMYYRIYQEADRQERlvyrskvaalllekhlQISQIPKPRPSIQVEQSTistmrrerKA 348
Cdd:cd15351  149 ---AVILCLIVFFLFMLVlMLVLYIHMFILACRHSQ----------------SISSQQRRQCPHQQTASL--------KG 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLCDS---CITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15351  202 AITLTILLGIFFLCWGPFFLHLTLIVTCPThpfCLCYFKYFNLFLILIICNSIIDPLIYAFRSQELR 268
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
112-415 2.50e-14

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 72.65  E-value: 2.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15196    5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLVKYLQVVGM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYpLIMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTTENYKYLKSNPHICEFKVNKA 271
Cdd:cd15196   85 YASSYVLVATAIDRYIAICHPLSS-HRWTSRRVHLMVAIAWVLSLLLS-IPQLFIFSYQEVGSGVYDCWATFEPPWGLRA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYqeadrqeRLVYRSKVAALLLekhlqisqipkprpsiqveqstistmrrerkaarT 351
Cdd:cd15196  163 YITWFTVAVFVVPLIILAFCYGRIC-------YVVWRAKIKTVKL----------------------------------T 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 352 LGIImSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15196  202 LVVV-ACYIVCWTPFFVVQMWAAWDPTAPIEGPAFVIIMLLASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
119-415 3.18e-14

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 72.52  E-value: 3.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 119 LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMI--SGKWMF-GSVMCDMWNSFDVYFST--- 192
Cdd:cd15103   12 IVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILlnNGYLVPrDSFEQHIDNVIDSMICSsll 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpallsflpiCSGWYTTTENYKylksnphicefkvNKAY 272
Cdd:cd15103   92 ASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVF---------CTVCGILFIIYS-------------DSVP 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaaLLLEKHLQ-ISQIPKPRPSIQveqstistmRRERKAART 351
Cdd:cd15103  150 VIICLISMFFAMLVLMASLYVHMF-----------------LLARSHVKkIAALPGQRSTRQ---------RANMKGAVT 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDS---CITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15103  204 LTILLGVFIFCWAPFFLHLTLMISCPSnpyCACYMSHFNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
107-292 4.84e-14

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 72.11  E-value: 4.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGfiilaaILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGkWMFGSVMCDMWNSF 186
Cdd:cd15177    6 VYLVVFVLG------LVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLL-TLPFAAAETLQG-WIFGNAMCKLIQGL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQ--PLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSgwYTTTENykylKSNPHIC 264
Cdd:cd15177   78 YAINFYSGFLFLTCISVDRYVVIVRatSAHRLRPKTLFYSVLTSLIVWLLSILFA-LPQLI--YSRVEN----RSELSSC 150
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 281362294 265 EFK--------VNKAYAIVSSSMSFWIPGIVMLSMY 292
Cdd:cd15177  151 RMIfpevvsrtVKGATALTQVVLGFAIPLIVMAVCY 186
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
117-412 5.52e-14

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 71.62  E-value: 5.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVAlCAMTFNASVMISGkWMFGSVMCDMWNS-FDVYFSTaSI 195
Cdd:cd15182   10 VFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFT-FTLPFWASYHSSG-WIFGEILCKAVTSiFYIGFYS-SI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSgwYTTTENykylKSNPHICEFKVNKAY--A 273
Cdd:cd15182   87 LFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELIL--STVMKS----DEDGSLCEYSSIKWKlgY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 274 IVSSSMSFWIPGIVMLSMYYRIYQEadrqerlVYRSKvaalllekhlqisqipkprpsiqveqstistMRRERKAARTLG 353
Cdd:cd15182  161 YYQQNLFFLIPLGIIVYCYVRILQT-------LMRTR-------------------------------TMRKHRTVKLIF 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 354 IIMSAFLICWLPF----FLWYIVSSLCDSCITPRLLVGILFW---IGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15182  203 VIVLVFFLSWAPYniviFLRSLKDLTIPICECSKQLDYAFYIcrnIAFSHCCLNPVFYVFVGVKFR 268
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
116-415 5.98e-14

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 71.91  E-value: 5.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15125    9 LIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVGVSV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS-----FLPICSgwYTTTENYKYLKSNPHICEFKVN- 269
Cdd:cd15125   89 FTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAvpeavFSEVAH--IMPDDNTTFTACIPYPQTDEMHp 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIYQeadrqerlvyrskvaALLLEKHlqisQIPKprpsiQVEQSTISTMRRERKAA 349
Cdd:cd15125  167 KIHSVLIFLVYFLIPLAIISIYYYHIAK---------------TLIKSAH----NIPG-----EYSEHSKRQMETRKRLA 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSL----CDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15125  223 KIVLVFVGLFAFCWFPNHVLYMYRSFnyneIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
112-412 6.10e-14

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 71.78  E-value: 6.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCdMWNSF-DVYF 190
Cdd:cd15078    5 LLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGC-VWDGFsNSLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVqpldYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKVNK 270
Cdd:cd15078   84 GIVSIMTLTVLAYERYIRVV----HAKVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEVHGLGCSFDWKSKDPNDT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskVAALLLEKHLQISQipkprpsiqveqsTISTMRRERKAAR 350
Cdd:cd15078  160 SFVLLFFLGCLVVPLGIMAYCYGHILYE------------IRMLRSVEDLQTFQ-------------VIKILKYEKKVAK 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 351 TLGIIMSAFLICWLPF-FLWYIVSSLCDSCITPRLLVgILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15078  215 MCLLMISTFLICWMPYaVVSLLVTSGYSKLVTPTIAI-IPSLFAKSSTAYNPVIYIFMIRKFR 276
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
113-412 6.94e-14

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 71.73  E-value: 6.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15075    6 IMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAFFGI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDyPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYT-------TTENYKYLKSNPHice 265
Cdd:cd15075   86 AALCTVAVIAVDRLFVVCKPLG-TLTFQTRHALAGIASSWLW-SLIWNTPPLFGWGSyqlegvmTSCAPDWYSRDPV--- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 fkvNKAYAIVSSSMSFWIPGIVMLSMYyriyqeadrqERLVYRSKVAALLlekhlqisqipkprpsiQVEQSTiSTMRRE 345
Cdd:cd15075  161 ---NVSYILCYFSFCFAIPFAIILVSY----------GYLLWTLRQVAKL-----------------GVAEGG-STAKAE 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 346 RKAARTLGIIMSAFLICWLPF-FLWYIVSSLCDSCITPrlLVGIL-FWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15075  210 VQVARMVVVMVMAFLLCWLPYaAFALTVVSKPDVYINP--LIATVpMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
105-412 9.08e-14

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 71.32  E-value: 9.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 105 ALVFVKCFIIGFIilaailGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGkWMFGSVMCDMWN 184
Cdd:cd15181    4 PLAYSLVFLLGVV------GNGLVLTILLRRRRSRRTTENYLLHLALADLLL-LLTFPFSVVESIAG-WVFGTFLCKLVG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 185 SFD-VYFSTASIMhLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS-----FLPICSGWYTTTENYKYlk 258
Cdd:cd15181   76 AIHkLNFYCSSLL-LACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSlpnlvFLEVETSTNANRTSCSF-- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 259 SNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQeadrqeRLVYRSkvaalllekhlqisqipkPRPSIQveqst 338
Cdd:cd15181  153 HQYGIHESNWWLTSRFLYHVVGFFLPLLIMGYCYATIVV------TLCQSS------------------RRLQKQ----- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 339 istmrrerKAARTLGIIMSAFLICWLPFFLWYIVSSLCD------SCITPRLL---VGILFWIGYFNSALNPIIYAYFNR 409
Cdd:cd15181  204 --------KAIRVAILVTLVFCLCWLPYNIVIFLDTLDDlkavvkNCKLNDLLdaaITVTESLGFSHCCLNPILYAFIGV 275

                 ...
gi 281362294 410 DFR 412
Cdd:cd15181  276 KFR 278
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
112-413 2.07e-13

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 70.18  E-value: 2.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIG---FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15398    2 FLIGlytFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLimTQRRVFIMLLMVW-LSPALLSFLPIcsgWYTTTENYKYLKSNPHICEFK 267
Cdd:cd15398   82 VSVMVSTLMLMSIAIVRYHMIKHPLSNHL--TANHGYFLLGTVWtLGFTICSPLPV---FHKIVDLSETFNLESLKNKYL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSSSMSFwipGIVMLSMYYriyqeadrqerlvyrskvaaLLLEKHLQISQipkprpsiqveQSTISTMRRERK 347
Cdd:cd15398  157 CIESWPSDSYRIAF---TISLLFVQY--------------------ILPLVCLTVSH-----------TSVCRSVKRSRS 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 348 AARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPR---LLVGILFWIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd15398  203 VFYRLTIVILAFAVSWMPLHLFHLVTDFNANLISNRhfkLVYCICHLLGMLSCCLNPILYGFLNNGIKS 271
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
113-415 2.62e-13

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 70.26  E-value: 2.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRII---TNYFVVSLAVADMLVALCAM---TFNAsVMISGKWMFGSVMCDMWNSF 186
Cdd:cd15355    6 IYLALFVVGTVGNSITLYTLARKKSLQHLqstVHYHLASLALSDLLILLLAMpveLYNF-IWVHHPWAFGDAACRGYYFL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIcsgwYTTTENYKYLKSNPH-ICE 265
Cdd:cd15355   85 RDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPML----FTMGEQNRSGTHPGGlICT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 FKVNKAYAI----VSSSMSFWIPGIVMLSMYYRIyqeADRQERLVYRSkvaalLLEKHLQISQIPKPRPSIQVEQSTIST 341
Cdd:cd15355  161 PIVDTSTLKvviqVNAFLSFLFPMLVISVLNTLI---ANQLTVMVNQA-----EQENQVCTIGGQRTVLSVSMEPGRVQS 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 342 MRRERKAARTLGIimsAFLICWLPFFL----------WYIVSSLCDSCITPRLLVGILFwigYFNSALNPIIYAYFNRDF 411
Cdd:cd15355  233 LRHGVLVLRAVVI---AFVVCWLPYHVrrlmfcyvsdEQWTTFLYDFYHYFYMLTNVLF---YVSSAINPILYNLVSANF 306

                 ....
gi 281362294 412 RAAF 415
Cdd:cd15355  307 RQIF 310
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
115-415 2.68e-13

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 69.84  E-value: 2.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAILGNMLVIVSVMRHRKLRII--TNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd14976    8 MVVFTVGLLGNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKLNMY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSflpICSGWYTTTEnykyLKS-NPHICEFKVNK- 270
Cdd:cd14976   88 SSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAA---IPEAIFSTDT----WSSvNHTLCLLRFPKn 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 -----------AYAIVSSSMSFWIP-GIVMLSMyyriyqeadrqerlvyrskvaaLLLEKHLQisqipkprpsiqveQST 338
Cdd:cd14976  161 ssvtrwynwlgMYQLQKVVLGFFLPlGIITLSY----------------------LLLLRFLQ--------------RKR 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 339 ISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFW---------IGYFNSALNPIIYAYFNR 409
Cdd:cd14976  205 GGSKRRKSRVTKSVFIVVLSFFICWLPNQALSLWSALIKFDDVPFSDAFFAFQtyafpvaicLAHSNSCLNPVLYCLVRR 284

                 ....*.
gi 281362294 410 DFRAAF 415
Cdd:cd14976  285 EFRDAL 290
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
112-412 2.98e-13

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 69.51  E-value: 2.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIilaailGNMLVIVSVMRHRKLRIITNYFVVSLAVADmLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15183   11 FIIGVV------GNVLVVLVLIQHKRLRNMTSIYLFNLAISD-LVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPiCSGWYTTTENYKYLKSNPH-----ICEF 266
Cdd:cd15183   84 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILAS-MP-CLYFFKSQWEFTHHTCSAHfprksLIRW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIvsSSMSFWIPGIVMLSMYYRIYqeadrqeRLVYRskvaalllekhlqisqipkpRPSiqveqstistmRRER 346
Cdd:cd15183  162 KRFQALKL--NLLGLILPLLVMIICYTGII-------NILLR--------------------RPN-----------EKKA 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 347 KAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPR--------LLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15183  202 KAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPSceqsqqldLALQVTEVIAYTHCCVNPVIYVFVGERFR 275
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
119-415 3.01e-13

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 69.53  E-value: 3.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 119 LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAM--TFNASVMISGKWMFGSVMCD-MWNSFDVYFS---T 192
Cdd:cd15352   12 IVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSleTIMIAVLNSGYLVISDQFIQhMDNVFDSMICislV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTenykylksnphicefkvnkay 272
Cdd:cd15352   92 ASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYSESKTV--------------------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 aIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaallLEKHLQISQIPKPRPSIQVEQSTISTMrrerKAARTL 352
Cdd:cd15352  151 -IVCLITMFFAMLVLMATLYVHMF-------------------LFARLHVKRIAALPPAVDGAPQQRSCM----KGAVTI 206
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDS---CITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15352  207 TILLGVFIVCWAPFFLHLILIISCPHnpyCLCYTSHFNTYLVLIMCNSVIDPLIYAFRSLEMRKTF 272
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
119-415 3.30e-13

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 69.55  E-value: 3.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 119 LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALC--AMTFNASVMISGKWMFGSVMCDMWNSFDVYFST---A 193
Cdd:cd15353   12 IVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSngSETVVITLLNGNDTDAQSFTVNIDNVIDSVICSsllA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 194 SIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGwytttenykylksnphicefkvNKAYA 273
Cdd:cd15353   92 SICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFIIYS----------------------DSSVV 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 274 IVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaaLLLEKHLQ-ISQIPKPRPSIQVEQstistmrreRKAARTL 352
Cdd:cd15353  150 IICLISMFFTMLALMASLYVHMF-----------------LLARLHIKrIAVLPGTGPIRQGAN---------MKGAITL 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDS---CITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15353  204 TILLGVFVVCWAPFFLHLIFYISCPRnpyCVCFMSHFNMYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
121-412 3.58e-13

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 69.50  E-value: 3.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 121 AILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCdMWNSFDV-YFSTASIMHLC 199
Cdd:cd15085   14 SIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFC-IFQGFAVnYFGIVSLWSLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 200 CISVDRYYAIVQPLDyPLIMTQRRVFIMLLMVWLSPALLSFLPI--------------CS-GWYTTT-ENYKYLksnphi 263
Cdd:cd15085   93 LLAYERYNVVCKPMG-GLKLSTKRGYQGLLFIWLFCLFWAVAPLfgwssygpegvqtsCSiGWEERSwSNYSYL------ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 264 cefkvnkayaIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhLQISQIPKprpSIQvEQSTISTMR 343
Cdd:cd15085  166 ----------ILYFLMCFVIPVAIIGFSYGNVL-----------------------RSLHKLNK---KIE-QQGGKNCPE 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 344 RERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15085  209 EEERAVIMVLAMVIAFLICWLPYTVFALIVVVNPELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
117-412 4.04e-13

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 69.33  E-value: 4.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGkWMFGSVMCDMWNS-FDVYFsTASI 195
Cdd:cd15180   10 VFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILL-LVTLPFWAVQAVHG-WIFGTGLCKLAGAvFKINF-YCGI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVqpldYPLIMTQRR----VFIMLLMVWLSPALLSflpICSGWYTTTENYKYLKSNPHICEFKVNKA 271
Cdd:cd15180   87 FLLACISFDRYLSIV----HAVQMYSRKkpmlVHLSCLIVWLFCLLLS---IPDFIFLEATKDPRQNKTECVHNFPQSDT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSS-----MSFWIPGIVMLSMYYRIyqeadrqerlvyrskVAALLLEKHLQisqipkprpsiqveqstistmrRER 346
Cdd:cd15180  160 YWWLALRllyhiVGFLLPLAVMVYCYTSI---------------LLRLLRSSQGF----------------------QKQ 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 347 KAARTLGIIMSAFLICWLPFFLWYIVsslcDSCITPRLLVG-------------ILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15180  203 RAIRVIVAVVVVFFLCWTPYNIALLV----DTLIDLSVLDRncgtesrldialsVTSSLGYFHCCLNPLLYAFVGVKFR 277
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
117-412 5.52e-13

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 69.01  E-value: 5.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGkWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15174   10 IFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLF-LCTLPFWATAASSG-WVFGTFLCKVVNSMYKINFYSCML 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVF--IMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYAI 274
Cdd:cd15174   88 LLTCISVDRYIAIVQATKAHNSKNKRLLYskLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYPSNESNRFKVAVL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 275 V-SSSMSFWIPGIVMLSMYyriyqeadrqeRLVYRSKVAALLLEKHlqisqipkprpsiqveqstistmrrerKAARTLG 353
Cdd:cd15174  168 AlKVTVGFFLPFVVMVICY-----------TLIIHTLLQAKRFQKH---------------------------KALKVII 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 354 IIMSAFLICWLPFFLWYIVSSL---------CDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15174  210 AVVTVFVLSQLPYNSILLIKTInaynititdCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFR 277
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
107-415 1.08e-12

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 67.88  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIgfiilaaiLGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcamTFNASVMISGKWMF----------- 175
Cdd:cd15102    8 VAICCFIV--------LENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGA---AYLANILLSGARTLrlspaqwflre 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 176 GSVMCDMwnsfdvyfsTASIMHLCCISVDRYYAIVQPLDYPLIMTQRrVFIMLLMVWLSPALLSFLPICsGWYTTtenyk 255
Cdd:cd15102   77 GSMFVAL---------SASVFSLLAIAIERHLTMAKMKPYGASKTSR-VLLLIGACWLISLLLGGLPIL-GWNCL----- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 256 ylkSNPHICEFKV---NKAYaIVSSSMSFWIPGIVMLSMYYRIYqeadrqeRLVyrskvaalllekhlQISQIPKPRPSi 332
Cdd:cd15102  141 ---GALDACSTVLplySKHY-VLFCVTIFAGILAAIVALYARIY-------CLV--------------RASGRKATRAS- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 333 qveqstisTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPrllvgILFWIGYF------NSALNPIIYAY 406
Cdd:cd15102  195 --------ASPRSLALLKTVLIVLLVFIACWGPLFILLLLDVACPVKTCP-----ILYKADWFlalavlNSALNPIIYTL 261

                 ....*....
gi 281362294 407 FNRDFRAAF 415
Cdd:cd15102  262 RSRELRRAV 270
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
122-415 1.15e-12

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 68.01  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 122 ILGNMLVIVSVMRHRKLRIITNY-FVVSLAVADMLVAL----CAMTFNASVMISGKWMFGSVMCDMWNSFdvyfsTASIM 196
Cdd:cd15340   15 VLENLLVLCVILHSRSLRCRPSYhFIGSLAVADLLGSVifvySFLDFHVFHRKDSPNVFLFKLGGVTASF-----TASVG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWyttteNYKYLKSN-----PHICEfkvnka 271
Cdd:cd15340   90 SLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLL-GW-----NCKKLNSVcsdifPLIDE------ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 yaivsSSMSFWIpGIVMLSMYYRIYQEAdrqeRLVYRSKVAAL-LLEKHLQISQIPKPRPSIQVEQSTISTMRRERKAAR 350
Cdd:cd15340  158 -----TYLMFWI-GVTSVLLLFIVYAYM----YILWKAHHHAVrMLQRGTQKSIIVYTSEDGKVQTTRPDQTRMDIRLAK 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15340  228 TLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
112-413 1.25e-12

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 67.49  E-value: 1.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIIlaAILGNMLVI-VSVMRHRklRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15115    7 LSLTFLL--GVPGNGLVIwVAGLKMK--RTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVLN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSgwYTTTenykYLKSNPHICEFKVNK 270
Cdd:cd15115   83 MFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLC-LPVFI--YRTT----VTDGNHTRCGYDFLV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIyqeADRQERLVYRskvaalllekhlqisqipkprpsiqveqstistmRRERKAAR 350
Cdd:cd15115  156 AITITRAVFGFLLPLLIIAACYSFI---AFRMQRGRFA----------------------------------KSQSKTFR 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCD--SCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd15115  199 VIIAVVVAFFVCWAPYHIIGILSLYGDppLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
117-415 1.52e-12

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 67.50  E-value: 1.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISG------KWMFGSVMCDMWNSFDVYF 190
Cdd:cd15350   10 IAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADmgylnrRGPFETKLDDIMDSLFCLS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLspallsflpICSGwytttenykylkSNPHICEFKVNK 270
Cdd:cd15350   90 LLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWT---------FCGG------------SGILMILFFHFV 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMsFWIPGIVMLSMYYRIYQEADRQERlvyrsKVAALllekhlqisqipkPRPSIQVEQSTIstmrrerKAAR 350
Cdd:cd15350  149 ATVICFTVL-FFLMLVLILCLYVHMFLLARSHAR-----KIASL-------------PNHHAQHQRSNM-------RGAI 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCDS---CITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15350  203 TLTILLGVFVCCWAPFVLHLLLMMFCPMnpyCACYRSLFQVNGTLIMSHAVIDPAIYAFRSPELRNTF 270
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
115-412 1.57e-12

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 67.92  E-value: 1.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMwNSFDVYFS-TA 193
Cdd:cd15395    8 SAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKL-NSMVQCISiTV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 194 SIMHLCCISVDRYYAIVQPLDYPliMTQRRVFIMLLMVWLSpALLSFLPICSGWYTTTENYKYLK------SNPHIC--- 264
Cdd:cd15395   87 SIFSLVLIAIERHQLIINPRGWR--PNNRHAYVGIAVIWVL-AVLTSLPFLIFQVLTDEPFKNVNvsldayKGKYVCldq 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 --EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAalllekhlqisqipKPRPSiqvEQSTISTM 342
Cdd:cd15395  164 fpSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNMMDKMRDN--------------KYRSS---ETKRINIM 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 343 rrerkaartLGIIMSAFLICWLPFFLWYIVSSLCDSCITP---RLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15395  227 ---------LISIVVAFAVCWLPLNIFNAVFDWNHEAIATcnhNLLFLICHLTAMISTCVNPIFYGFLNKNFQ 290
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
116-412 1.99e-12

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 67.16  E-value: 1.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15080    9 LLILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIAL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDyPLIMTQRRVFIMLLMVWLSpALLSFLPICSGW-------YTTTENYKYLKSNPHIcefkV 268
Cdd:cd15080   89 WSLVVLAIERYVVVCKPMS-NFRFGENHAIMGVAFTWVM-ALACAAPPLVGWsryipegMQCSCGIDYYTLKPEV----N 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYyriyqeadrqERLVYRSKVAAlllekhlqisqipkprpsiQVEQSTISTMRRERKA 348
Cdd:cd15080  163 NESFVIYMFVVHFTIPLIVIFFCY----------GRLVCTVKEAA-------------------AQQQESATTQKAEKEV 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 349 ARTLGIIMSAFLICWLPF--FLWYIVSSLcDSCITPRLLVGILFWiGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15080  214 TRMVIIMVIAFLICWVPYasVAFYIFTHQ-GSDFGPIFMTIPAFF-AKSSAVYNPVIYILMNKQFR 277
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
112-412 2.08e-12

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 67.00  E-value: 2.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILA-AILG---NMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAmTFNASVMISGKWMFGSVMCDMWNSFD 187
Cdd:cd15072    1 FAVGSILLVeALVGfslNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNA-LVAASSSLLRRWPYGSEGCQAHGFQG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDYplimTQRRVFIMLLMVWLSPALLSFLPICsGWytttENYKYlksNPH--ICE 265
Cdd:cd15072   80 FFTALASICSSAAIAWDRYHHYCTRSKL----QWSTAISLVLFVWLFSAFWAAMPLL-GW----GEYDY---EPLgtCCT 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 FKVNK------AYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaaLLLEKHLQISQipkprpsiqveqsti 339
Cdd:cd15072  148 LDYSKgdrnyvSYLFTMAFFNFILPLFILLTSYSSIEQK---------------LKKEGHLRFNT--------------- 197
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 340 stmrrerkaartlGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15072  198 -------------GLPLLTLLICWGPYAILALYAAITDVTSISPKLRMVPALLAKTSPTINAILYALGNENYR 257
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
114-415 3.46e-12

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 66.30  E-value: 3.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 114 IGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCdMWNSF-DVYFST 192
Cdd:cd15086    7 LGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGC-RWYGFaNSLFGI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLiMTQRRVFIMLLMVWLSpALLSFLPICSGWY--------TTTENYKYLKSNPHIc 264
Cdd:cd15086   86 VSLISLAVLSYERYCTLLRPTEADV-SDYRKAWLGVGGSWLY-SLLWTLPPLLGWSsygpegpgTTCSVQWTSRSANSI- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 efkvnkAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaaLLLEKhlQISQIpkprpsiqveqSTISTMRR 344
Cdd:cd15086  163 ------SYIICLFIFCLLLPFLVMVYCYGRL------------------LYAIK--QVGKI-----------NKSTARKR 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 345 ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCD-SCITPRLLVgILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15086  206 EQHVLLMVVTMVICYLLCWLPYGVMALLATFGKpGLVTPVASI-VPSILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
117-415 7.99e-12

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 65.97  E-value: 7.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVI--VSVMRHRK--LRIITNYfVVSLAVADMLVALCAM--TFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15135   10 ILVAGILGNSATIkvTQVLQKKGylQKSVTDH-MVSLACSDLLVLLLGMpvELYSAIWDPFATPSGNIACKIYNFLFEAC 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYpLIMTQRRVFIMLLMVWLSPALLSfLPICsgWYTTTENYKYLKSNPHICEFKVNK 270
Cdd:cd15135   89 SYATILNVATLSFERYIAICHPFKY-KALSGSRVRLLICFVWLTSALVA-LPLL--FAMGTEDPLEAFPSYRGTRHHCQD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 ayaiVSSSMSFWIPgivmLSMYYRIYQEADRQERLVYRSKVAAL-----LLEKHLQISQipKPRPSIQVEQSTISTMRR- 344
Cdd:cd15135  165 ----QKSNLTICTS----LSSKWTVFQASIFSAFVLYLLVLASVafmcrRMMRALMGSK--KGAVAVKGPGGSVQLLRKh 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 345 ---ERKAART-----LGIIMSAFLICWLPFFLWYIVS----------SLCDSCITPRLLVGILFwigYFNSALNPIIYAY 406
Cdd:cd15135  235 esaEGKTARKqtilfLGLIVGTLAVCWMPNQIRRIMAaakpkddwtrSYFRAYIILLPIADTFF---YLSSVLNPLLYNL 311

                 ....*....
gi 281362294 407 FNRDFRAAF 415
Cdd:cd15135  312 SSQQFRSVF 320
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
113-407 1.02e-11

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 65.18  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15388    6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPldyplimtqrrvfimlLMVWLSPALLSFLPICSGWYTTtenykYLKSNPHICEF-KVN-- 269
Cdd:cd15388   86 ASSYMIVAMTFDRHQAICRP----------------MVTFQKGRARWNGPVCVAWAIS-----LILSLPQVFIFsKVEva 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 ----------------KAYAIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlVYRSKVaaLLLEKHLQISQIPKPRPSIQ 333
Cdd:cd15388  145 pgvyecwacfiepwglKAYVTWITLVVFVLPTLIITVCQVLIFKE-------IHINIY--LKSQIIVAVVKKKQLLSSRA 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 334 VEQSTISTMRreRKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYF 407
Cdd:cd15388  216 SSVAEVSKAM--IKTVKMTLVIVLVYVLCWAPFFLVQLWSVWDPKAPTEGATFTILMLLASLNSCTNPWIYMAF 287
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
122-403 1.14e-11

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 64.77  E-value: 1.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 122 ILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFnasvmisgKWMFGSVMCDMWNSFDVY----FSTASIM- 196
Cdd:cd15905   13 IFANLFIILGIACNRKLHNTANYFFLSLLLADLLTGVALPFI--------PGMSNESRRGYHSCLFVYvapnFLFLSFLa 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGW--YTTTEN--YKYLKSNPHIcefkVNKAY 272
Cdd:cd15905   85 NLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLPAL-GWnnWTPGSNcsYKQVFPAAYI----YLEVY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMsfwipgIVMLSMYYRIYQEADRqerlvyrskvaalllekhlQISQIPKPRPSIQVEQSTISTMRRERKAARTL 352
Cdd:cd15905  160 GLVLPSI------LAIAFMSVRVLAVARR-------------------QLQDICKLLRAVQRDGPSELEQQLNLRYAKCI 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDSCITP--RLLVGILFWIGYFNSALNPII 403
Cdd:cd15905  215 AGVSLTFLVCWVPYIAYLLMSVLAIEQRPPlsPGTLLILSCVGSGSAAAVPVI 267
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
117-414 1.19e-11

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 64.88  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCdmwnSFDVYFST---- 192
Cdd:cd15194   10 VFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLC----KGSSYIISvnmy 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHIcefKVNKAY 272
Cdd:cd15194   86 CSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAGT---PSKVIF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIVSSSMSFWIPGIVMLSMYYRIYQEadrqerlvyrskvaallLEKHLQISQipkprpsiqveqstiSTMRRERKAARTL 352
Cdd:cd15194  163 SLVSLIVAFFLPLLSILTCYCTIIWK-----------------LCHHYQKSG---------------KHQKKLRKSIKIV 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 353 GIIMSAFLICWLPFFLW---YIVSSL-----CDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15194  211 FIVVAAFVFSWMPFNLFkalAIASGLqvevtCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRRA 280
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
113-412 1.25e-11

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 65.14  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVI-VSVMRHRklRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15117    6 IYSSAFVLGTLGNGLVIwVTGFRMT--RTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFlPICSGWYTTTEN---YKYLKSNPH------ 262
Cdd:cd15117   84 FASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSG-PHLVFRDTRKENgctHCYLNFDPWnetaed 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 -----ICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvAALLLEKHlqisqipkprpsiqveqs 337
Cdd:cd15117  163 pvlwlETVVQRLSAQVITRFVLGFLVPLVIIGGCYGLI----------------AARLWREG------------------ 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 338 tistMRRERKAARTLGIIMSAFLICWLPFF------LWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDF 411
Cdd:cd15117  209 ----WVHSSRPFRVLTAVVAAFFLCWFPFHlvslleLVVILNQKEDLNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDF 284

                 .
gi 281362294 412 R 412
Cdd:cd15117  285 R 285
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
100-414 1.29e-11

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 64.81  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 100 GSSHLALVFVKCFIIgfiilaaiLGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcamTFNASVMISGKWMFGSVM 179
Cdd:cd15349    1 GALTVLFICISVLII--------LENLLVLLAILRRVRLRRWVYICLANIALSDLLTGT---SYLVNICLSGERTFRLTP 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 180 CDMWNSFDVYFST--ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTttenykyl 257
Cdd:cd15349   70 ALWFLREGLLFTAlaASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLL-GWNC-------- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 258 ksnphICEFK--------VNKAYaIVSSSMSFWIPGIVMLSMYYRIYqeadrqeRLVYRSKvaalllekhlqiSQIPKPR 329
Cdd:cd15349  141 -----LCDFRscssllplYSKSY-ILFCLVIFFIILLTIIGLYFAIY-------CLVRASG------------QRVISAR 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 330 PSiqveqstistmRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCD--SCITPRLLVGILFwIGYFNSALNPIIYAYF 407
Cdd:cd15349  196 SR-----------RRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCSsrSCKPLFGMEWVLA-LAVLNSAINPLIYSFR 263

                 ....*..
gi 281362294 408 NRDFRAA 414
Cdd:cd15349  264 SLEVRRA 270
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
125-414 1.75e-11

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 64.42  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 125 NMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVmisgkWMFGSVMCDMWN-SFDVYFSTASIMHLCCISV 203
Cdd:cd15100   18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGLILHFVFR-----YCVYSEALSLVSvGLLVAAFSASVCSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 204 DRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTENYKYLKSNPHIcefKVNKAYAIVSSSMSFWI 283
Cdd:cd15100   93 DRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVL-GWNCLREGSSCSVVRPLT---KNHLAVLAVAFLLVFAL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 284 pgivMLSMYYRIYqeadrqeRLVYRskvaalllekHLQisqipkprpSIQVEQSTISTMRR--ERKAARTLGIIMSAFLI 361
Cdd:cd15100  169 ----MLQLYAQIC-------RIVLR----------HAH---------QIALQRHFLAPSHYvaTRKGVSTLALILGTFAA 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 281362294 362 CWLPFFLWYIVSSLCDscitPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15100  219 CWIPFAVYCLLGDGSS----PALYTYATLLPATYNSMINPIIYAFRNQDIQKV 267
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
125-415 2.88e-11

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 63.51  E-value: 2.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 125 NMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMT-FNASVMISGKWMFGSVMCDMWNSFdvyfsTASIMHLCCISV 203
Cdd:cd15961   18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLILnFIFAYLLQSEAAKLVTVGLIVASF-----SASVCSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 204 DRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIcSGWYTTTEnykylKSNPHICEFKVNKAYAIVssSMSFWI 283
Cdd:cd15961   93 DRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPV-MGWNCLAD-----ESTCSVVRPLTKNNAAIL--SVSFLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 284 PGIVMLSMYYRIYqeadrqeRLVYRSKVAALLLEKHLQISQIpkprpsiqveqstISTmrreRKAARTLGIIMSAFLICW 363
Cdd:cd15961  165 MFALMLQLYIQIC-------KIVMRHAHQIALQHHFLATSHY-------------VTT----RKGVSTLAIILGTFAACW 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 281362294 364 LPFFLWyivsSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15961  221 MPFTLY----SLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
112-243 3.27e-11

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 63.80  E-value: 3.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNY--FVVSLAVADMLVALCAMTFNASVMISG-KWMFGSVMCDMWNSFDV 188
Cdd:cd14981    5 APPALMFVFGVLGNLLALIVLARSSKSHKWSVFyrLVAGLAITDLLGILLTSPVVLAVYASNfEWDGGQPLCDYFGFMMS 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPI 243
Cdd:cd14981   85 FFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPL 139
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
104-415 3.92e-11

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 63.56  E-value: 3.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 104 LALVFVKCFIIGFiilaaiLGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMW 183
Cdd:cd15967    3 LPPVYILVFVVGL------VGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKIT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 184 NSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPAL-----LSFL---PICSGWYTTTENyK 255
Cdd:cd15967   77 RFCFNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIqslpdLFFSktnSNGTKCFDTTFN-D 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 256 YLKSnphicefkvNKAYAIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrSKVAALLLEKhlqisqipkprpsiqve 335
Cdd:cd15967  156 YLES---------YLTYSLGWTVTGFVIPLLIILGCY----------------GHVVVVLCRN----------------- 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 336 qSTISTMRRERkAARTLGIIMSAFLICWLPFF------LWYIVSSLCDSCITPRLLVGILFWIGY----FNSALNPIIYA 405
Cdd:cd15967  194 -NNVDKGLKQR-CLKLVIILIVLFSVCYIPYHvfrnlnLLSRILQKQGSCTQWFRGIYIAHQVSRglvcLNSALNPLVYL 271
                        330
                 ....*....|
gi 281362294 406 YFNRDFRAAF 415
Cdd:cd15967  272 MGSEDILSRI 281
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
119-415 5.12e-11

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 63.03  E-value: 5.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 119 LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCA--------MTFNASVMISGKwmFGSVMCDMWNSFDVYF 190
Cdd:cd15354   12 IISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNawetitiyLLNNRHLVIEDA--FVRHIDNVFDSLICIS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlspallSFLPICSGWYTTTENYKYLksnphicefkvnk 270
Cdd:cd15354   90 VVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW------TFCTGCGIIFILYSESTYV------------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 ayaIVSSSMSFWIPGIVMLSMYYRIYqeadrqerLVYRSKVAalllekhlQISQIPKPRPSIQveqstistmRRERKAAR 350
Cdd:cd15354  151 ---IICLITMFFAMLFLMVSLYIHMF--------LLARTHVK--------RIAALPGYNSVRQ---------RTSMKGAV 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIVSSLCdscitPRLLVGILFwIGYF---------NSALNPIIYAYFNRDFRAAF 415
Cdd:cd15354  203 TLTILLGIFIVCWAPFFLHLILMISC-----PQNLYCVCF-MSHFnmylilimcNSVIDPLIYAFRSQEMRKTF 270
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
108-415 6.18e-11

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 63.13  E-value: 6.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADML-VALCAMTFNASVMISGKWMFGSVMCDMWNSF 186
Cdd:cd15218    1 FLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILrSAICFPFVFTSVKNGSTWTYGTLTCKVIAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSgwyttTENYKYLKSNPHiCEF 266
Cdd:cd15218   81 GVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLD-----VGTYSFIREEDQ-CTF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KvNKAYAIVSSSMSFWIPGIVMLS---MYYRIYQEADRQERLVYRSKVAALLLEKHLQ---------------ISQIPKP 328
Cdd:cd15218  155 Q-HRSFRANDSLGFMLLLALILLAtqlVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHgpgasgqaaanwlagFGRGPTP 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 329 RPSIQVEQSTISTMRR----------ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSA 398
Cdd:cd15218  234 PTLLGIRQNANTTGRRrllvldefkmEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAG 313
                        330
                 ....*....|....*..
gi 281362294 399 LNPIIYAYFNRDFRAAF 415
Cdd:cd15218  314 INPFVCIFSNRELRRCF 330
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
125-410 6.50e-11

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 62.59  E-value: 6.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 125 NMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWnsfdVYFSTASIMHLCCISVD 204
Cdd:cd15963   18 NAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLGLILHFAFVYCIQSAPVNLVTVGLL----APSFTASVSSLLAITID 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 205 RYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGW-----YTTTENYKYLKSNphicefkvnkayAIVSSSM 279
Cdd:cd15963   94 RYLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPVV-GWnclkdPSTCSVVKPLTKN------------HLVILSI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 280 SFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllEKHLQISQIPKprpsiqveqstiSTMRRERKAARTLGIIMSAF 359
Cdd:cd15963  161 SFFMVFALMLQLYAQICRIVCRHAH------------QIALQRHFLPT------------SHYVTTRKGIATLAVILGTF 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 281362294 360 LICWLPFflwyIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRD 410
Cdd:cd15963  217 ASCWLPF----AVYCLLGDYTYPALYTYATLLPATYNSMINPIIYAFRNQE 263
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
117-412 6.94e-11

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 62.93  E-value: 6.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15396   10 VTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSVSIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLlmVWLSPALLSFlPICSGWYTTTENYKYLKSNphiCEFKVNKAYAIvs 276
Cdd:cd15396   90 SLVLIAIERYQLIVNPRGWKPSASHAYWGIVL--IWLFSLMISI-PFLIFHQLTDEPFRNLSSH---SDFYKDKVVCI-- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 277 ssmSFWipgivmlsmyyriyqeADRQERLVYRSKVAAL--------LLEKHLQISQIPKPRPSIQVEQSTISTMRRERKA 348
Cdd:cd15396  162 ---EAW----------------PSETERLIFTTSLLVFqyfvplgfIFICYLKIFVCLKKRNSKIDRMRENESRLSENKR 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 349 ARTLGI-IMSAFLICWLPFFLWYIV----SSLCDSCiTPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15396  223 INTMLIsIVVTFAACWLPLNIFNVVfdwnHEVLMSC-HHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQ 290
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
107-414 8.58e-11

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 62.16  E-value: 8.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGfiiLAAILGNMLVIVSVMRHRKLRIITNY-FVVSLAVADMLVAL---CA-MTFNASVMISGKWMFGSVMCD 181
Cdd:cd15341    3 IAVLCTLCG---LLCILENVAVLYLILSSPKLRRKPSYlFIGSLALADFLASVvfaCSfVDFHVFHGVDSSAIFLLKLGG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 182 MWNSFdvyfsTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTENYKYLKSNP 261
Cdd:cd15341   80 VTMSF-----TASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLM-GWNCCPLNSPCSELFP 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 262 hicefkvnkayAIVSSSMSFWIPGIVMLsMYYRIYQEAdrqeRLVYRSKVAALLLEKHlQISQIPKprpsiqveqstIST 341
Cdd:cd15341  154 -----------LIPNDYLLSWLLLVAIL-LSGIIYTYG----HVLWKAHKHVVYMEKH-QDQQGPG-----------NAR 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 342 MRRERKAARTLGIIMSAFLICWLP---FFLWYIVSSLCDSCITPRLLVGILFWIgyfNSALNPIIYAYFNRDFRAA 414
Cdd:cd15341  206 MRLDVRLAKTLGLVLAVLLICWSPvlaLMMHSLFTSLSDHIKKAFAFCSTLCLV---NSMVNPIIYALRSRELRSS 278
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
125-414 1.14e-10

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 61.87  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 125 NMLVIVSVMRHRKLRIITNYFVVSLAVADMLvALCAMTFNasvmisgkWMFGSVMCDMWNS-----FDVYFSTASIMHLC 199
Cdd:cd15962   18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLL-AGCGLILN--------FVFQYVIQSETISlitvgFLVASFTASVSSLL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 200 CISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTEnykylKSNPHICEFKVNKAYAIVSSsm 279
Cdd:cd15962   89 AITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVL-GWNCLEE-----RASCSIVRPLTKSNVTLLSA-- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 280 SFWIPGIVMLSMYYRIYQEADRQERlvyrskvaALLLEKHLQisqipkprpsiqveqsTISTMRRERKAARTLGIIMSAF 359
Cdd:cd15962  161 SFFFIFILMLHLYIKICKIVCRHAH--------QIALQQHFL----------------TASHYVATKKGVSTLAIILGTF 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 360 LICWLPFFLWYIVSSLCDscitPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15962  217 GASWLPFAIYCVVGDHEY----PAVYTYATLLPATYNSMINPIIYAYRNQEIQRS 267
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
112-412 1.77e-10

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 61.38  E-value: 1.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGfiilaaILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15185   11 FIVG------LLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLF-LFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlSPALLSFLPICSgWYTTTENYKYLKSNPHICEFKVN-- 269
Cdd:cd15185   84 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITW-GLAVLAALPEFI-FYETQELFEEFLCSPLYPEDTEDsw 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 -KAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQerlvyrskvaalllekhlqisqipkprPSiqveqstistmRRERKA 348
Cdd:cd15185  162 kRFHALRMNIFGLALPLLIMVICYTGIIKTLLRC---------------------------PS-----------KKKYKA 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSS-----LCDSCITPR---LLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15185  204 IRLIFVIMVVFFIFWTPYNLVLLLSAfqsifFETDCERSKhldLAMQVTEVIAYTHCCINPVIYAFVGERFR 275
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
117-211 2.23e-10

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 60.93  E-value: 2.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMisGKWMFGSVMCD-MWNSFDVYFSTaSI 195
Cdd:cd15175   10 ICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAA--KKWVFGEEMCKaVYCLYKMSFFS-GM 86
                         90
                 ....*....|....*.
gi 281362294 196 MHLCCISVDRYYAIVQ 211
Cdd:cd15175   87 LLLMCISIDRYFAIVQ 102
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
125-412 2.88e-10

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 60.68  E-value: 2.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 125 NMLVIVSVMRHRKLRIITNYFVVSLAVADML---------VALCAMTFNASVMISGKWMFGSvmcdmwnsfdvyFStASI 195
Cdd:cd15960   18 NAIVIAILFYTPSLRAPMFILIGSLALADLLaglglianfVAIYVMNSEAVTLCSAGLLLAA------------FS-ASV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTEnykylKSNPHICEfKVNKAYAIV 275
Cdd:cd15960   85 CSLLAITVDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAM-GWNCLRA-----PASCSVLR-PVTKNNAAV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 276 sSSMSFWIPGIVMLSMYYRIYQEADRqerlvyrskvaalllekHLQisQIpkprpSIQVEQSTISTMRRERKAARTLGII 355
Cdd:cd15960  158 -LAVSFLLLFALMMQLYLQICRIAFR-----------------HAQ--QI-----AVQHQFVNFCLASSTRKGVSTLSLI 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 356 MSAFLICWLPFFLWYIVSslcDSCItPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15960  213 LATFAFCWVPFAVYSMVA---DSSY-PMIYTYYLVLPAACNSVINPIIYAFRNPDIQ 265
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
106-415 4.94e-10

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 59.89  E-value: 4.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 106 LVFVKCFIIgfiilaaiLGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcamTFNASVMISG---------KWMF- 175
Cdd:cd15346    7 FIIICCFII--------LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV---AYTANLLLSGattykltptQWFLr 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 176 -GSVMCDMwnsfdvyfsTASIMHLCCISVDRYYAIVQpLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTTEny 254
Cdd:cd15346   76 eGSMFVAL---------SASVFSLLAIAIERYITMLK-MKLHNGSNSFRSFLLISACWVISLILGGLPIM-GWNCISA-- 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 255 kyLKSNPHICEFkVNKAYAIVSSSM-SFWIPGIVMLsmYYRIYQEA-DRQERLVYRSKVAAlllekhlqisqipkprpsi 332
Cdd:cd15346  143 --LSSCSTVLPL-YHKHYILFCTTVfTLLLLSIVIL--YCRIYSLVrTRSRRLTFRKNIRK------------------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 333 qveqstiSTMRRERKAA--RTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPrllvgILFWIGYF------NSALNPIIY 404
Cdd:cd15346  199 -------ASRSSEKSMAllKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCS-----ILFKAEYFlvlavlNSATNPIIY 266
                        330
                 ....*....|.
gi 281362294 405 AYFNRDFRAAF 415
Cdd:cd15346  267 TLTNKEMRRAF 277
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
117-412 5.53e-10

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 59.79  E-value: 5.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADmLVALCAMTFNA-SVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15189   10 LCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAAD-LVFVSGLPFWAmNILNQFNWPFGELLCRVVNGVIKVNLYTSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSF-------LPICSGWYTTTENYKYLKSNPHIcefkv 268
Cdd:cd15189   89 YLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIptfllrkIKAIPDLNITACVLLYPHEAWHF----- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 nkAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQerlvyrskvaalllekhlqisqipkprpsiqvEQSTISTMRRERKA 348
Cdd:cd15189  164 --AHIVLLNIVGFLLPLLVITFCNYNILQALRTR--------------------------------EESTRCEDRNDSKA 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSLC-----DSCITPRLL-VGILF--WIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15189  210 TALVLAVTLLFLVCWGPYHFFTFLDFLFdvgvlDECFWEHFIdIGLQLavFLAFSNSCLNPVLYVFVGRYFR 281
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
114-415 5.99e-10

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 59.83  E-value: 5.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 114 IGFIIL--AAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcamTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15347    5 IFIVILccIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGV---AFIANILLSGSVTFRLTPVQWFIREGTAFI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 T--ASIMHLCCISVDRYYAIVQPLDYPLIMTQRrVFIMLLMVWLSPALLSFLPICsGWYTTtenykylkSNPHICE--FK 267
Cdd:cd15347   82 TlsASVFSLLAIAIERHVAITKVKLYGSDKNCR-MVLLIGACWVISIVLGGLPIL-GWNCI--------GNLEDCStvLP 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLlekhlqisqipkprpsiqveqstistmrrerk 347
Cdd:cd15347  152 LYSKHYILFVVTIFSIILLSIVILYVRIYCIVRSSHAEMAAPQTLALL-------------------------------- 199
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 348 aaRTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLL-VGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15347  200 --KTVTIVLGVFIVCWLPAFIILLLDTSCKVKSCPILYkADYFFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
112-239 6.60e-10

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 59.83  E-value: 6.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIilaailGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFnASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15121   11 FILGFP------GNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFF-LHFLSGGGWEFGSVVCKLCHYVCGVSM 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS 239
Cdd:cd15121   84 YASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLS 131
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
117-412 8.32e-10

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 59.40  E-value: 8.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVAlCAMTFNASVMISG-KWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15381   10 IFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLV-CCLPFWAINISNGfNWPFGEFLCKSVNAVIYMNLYSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPIcsgwyTTTENYKYLKS-NPHICEFKVNKAYAI 274
Cdd:cd15381   89 YFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMF-GLLMSTPM-----IVFRTVMYFPEyNITACVLDYPSEGWH 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 275 VSSSM-----SFWIPGIVMLSMYYRIYQeadrqerlvyrskvaALLLEKHLQISQIpkprpsiqveqstistmRRERKAA 349
Cdd:cd15381  163 VALNIllnvvGFLIPLSIITFCSTQIIQ---------------VLRNNKMQKFKEI-----------------QTERKAT 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLC-----DSCITPRLL---VGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15381  211 VLVLAVLLMFFICWLPFHIFTFLDTLHklgliSGCRWEDILdigTQIATFLAYSNSCLNPLLYVIVGKHFR 281
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
113-243 1.02e-09

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 59.14  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIilaAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMI---------SGKWMfGSVMCDMW 183
Cdd:cd15137    9 VVGII---ALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGV-YLLIIASVDLyyrgvyikhDEEWR-SSWLCTFA 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 184 NSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLImTQRRVFIMLLMVWLSPALLSFLPI 243
Cdd:cd15137   84 GFLATLSSEVSVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLLAVLPL 142
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
116-413 1.08e-09

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 59.02  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNsFDVYFST-AS 194
Cdd:cd15968    9 FVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVR-FLFYFNLyGS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYT-TTENYKYLKSNPHICEFKVNKAYA 273
Cdd:cd15968   88 ILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWIL-VFAQTLPILIFARTgIIRNRTVCYDLAPPALFPHYVPYG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 274 IVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhLQISQIPKPRPSIQVEqstistmrRERKAARTLG 353
Cdd:cd15968  167 MALTVSGFLLPFSIILWCYCLVV-----------------------RTLCRTLGPAEPPAQA--------RRRKSIRTIV 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 354 IIMSAFLICWLPF--------FLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd15968  216 TVTLLFALCFLPFhitrtiylAVRVTPGVPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGR 283
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
112-413 1.12e-09

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 59.04  E-value: 1.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGfIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15380    6 FIIA-ICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKANL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSflpICSGWYTTTENYKYLKSNPHICEFKV--- 268
Cdd:cd15380   85 FISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLS---IPTFLFRSVKHVPDLNISACILLFPHeaw 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlqisqipkprpsiqvEQSTISTMRRERKA 348
Cdd:cd15380  162 HFARRVELNIVGFLLPLAAIVFFNFHIIASLRERTE------------------------------ESRKRCGGLKDTKA 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 349 ARTLGIIMSAFLICWLPFFLWYIVSSL-----CDSCITPRLL-VGILF--WIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd15380  212 TRLILTLVLMFLVCWTPYHFFAFLDFLfqvevIQGCFWEEFIdLGLQLanFFAFANSCLNPVIYVFAGKLFRT 284
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
145-407 1.58e-09

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 58.52  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 145 FVVSLAVADMLVALCaMTFNASVMISGK-WMFGSVMCDMwnsfdVYFSTA-----SIMHLCCISVDRYYAIVQPLDYPLI 218
Cdd:cd15201   38 YLFNLAVADFLLIIC-LPFRTDYYLRGKhWKFGDIPCRI-----VLFMLAmnragSIFFLTAVAVDRYFRVVHPHHRINS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 219 MTQRRVFIMLLMVWLspallsfLPICSGWYTTTENYKYLKSNPHICE-FKVNKAYAIVSS------SMSFWIP-GIVMLS 290
Cdd:cd15201  112 ISVRKAAIIACGLWL-------LTIAMTVYLLTKKHLFPRGNATQCEsFNICTGTDSSSNwheamfLLEFFLPlAIILYC 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 291 MYYRIYQEADRQerlvyrskvaallLEKHLQIsqipkprpsiqveqstistmrreRKAARTLGIIMSAFLICWLP----- 365
Cdd:cd15201  185 SVRIIWQLRGRQ-------------LDRHAKI-----------------------KRAVQFIMVVAIVFIICFLPsnvtr 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 281362294 366 FFLWYIVSSLCDSCITPRlLVGILFWIG----YFNSALNPIIYaYF 407
Cdd:cd15201  229 IAIWILKHTSNEDCQYYR-SVDLAFYITisftYFNSMLDPVVY-YF 272
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
117-412 1.69e-09

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 58.26  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRH-RKLRIITNYFVVSLAVADMLVaLCAMTFNAsVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15188   10 VFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLLF-LVTLPFWA-MYVAWHWVFGSFLCKFVSTLYTINFYSGI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSflpICSGWYTTTENYK------YLKSNPHICEFKVn 269
Cdd:cd15188   88 FFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALS---VPDMVFVQTHHTNngvwvcHADYGGHHTIWKL- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 kAYAIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrSKVAALLlekhlqisqipkprpsiqveqsTISTMRRERKAA 349
Cdd:cd15188  164 -VFQFQQNLLGFLFPLLAMVFFY----------------SRIACVL----------------------TRLRPPGQGRAL 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSLCD-----SCITPRLL---VGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15188  205 RFVAALVVVFFVLWFPYNLTLFLHSLQDlhvigNCERSRHLdyaLQVTESLAFVHCCLNPLLYAFVSKRFR 275
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
112-412 2.88e-09

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 57.84  E-value: 2.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIIlaAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCaMTFNASVMISG-KWMFGSVMCDMwNSFDVYF 190
Cdd:cd14991    7 LILEFVL--GLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLIC-LPFRIDYYLRGeHWIFGEAWCRV-NLFMLSV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 S-TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFlpicsgwYTTTENYKYLKSNPHICEfkvn 269
Cdd:cd14991   83 NrSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTL-------PLLLSTLLTVNSNKSSCH---- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 kayaivssSMSFWIPGIVMLSMYYRIYQeadrQERLVyrskVAALLLEKHLQISQIPKPRPSIQVEqstistmRRERKAA 349
Cdd:cd14991  152 --------SFSSYTKPSLSIRWHNALFL----LEFFL----PLGLIVFCSVRIACNLRIRQSLGKQ-------ARVQRAI 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 350 RTLGIIMSAFLICWLP------FFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd14991  209 RLVFLVVIVFVLCFLPsiiaglLALVFKNLGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFR 277
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
113-408 3.53e-09

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 57.89  E-value: 3.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15386    6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLSMF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDyPLIMTQRRVFIMLLMVWLSPALLSFLPICSgwYTTTENYKylKSNPHIC--EFKVN- 269
Cdd:cd15386   86 ASTYMLIMMTVDRYIAVCHPLR-TLQQPSRQAYLMIGATWLLSCILSLPQVFI--FSLREVDQ--GSGVLDCwaDFGFPw 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 --KAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQerlvYRSKVAALLLEKHLQISQIPKPRpsiqveQSTISTMRRER- 346
Cdd:cd15386  161 gaKAYITWTTLSIFVLPVAILIVCYSLICYEICKN----LKGKTQTSRSEGGGWRTQGMPSR------VSSVRTISRAKi 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 347 KAARTLGIIMSAFLICWLPFF---LWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFN 408
Cdd:cd15386  231 RTVKMTFVIVLAYIACWAPFFsvqMWSVWDENAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFS 295
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
106-415 4.25e-09

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 57.13  E-value: 4.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 106 LVFVKCFIIGFIIlaAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMI-SGKWMFGSVMCDMwN 184
Cdd:cd15921    1 LFYPTAYILIFIL--GLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLL-VCTLPLRLTYYVlNSHWPFGDIACRI-I 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 185 SFDVYFST-ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHi 263
Cdd:cd15921   77 LYVLYVNMySSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCLELAH- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 264 ceFKVNKAYAI--VSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllekhlqISQIPKPRPSIQveqstiST 341
Cdd:cd15921  156 --DAVDKLLLInyVTLPVGFVVPFMTVIFCYIFI--------------------------IKNLLKPSPALG------RT 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 342 MRRERKAARTLGIIMSAFLICWLPF--------FLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd15921  202 RPSRRKACALIIISLGIFLVCFLPYhivrtihlITERQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRS 281

                 ..
gi 281362294 414 AF 415
Cdd:cd15921  282 RL 283
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
113-415 6.03e-09

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 56.70  E-value: 6.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVvSLAVADML--------VALCAMTFNasvmisgkWMFGSVMCDMwN 184
Cdd:cd15116    6 IYSVVFVLGVLGNGLVIFITGFKMKKTVNTVWFL-NLAVADFLftfflpfsIAYTAMDFH--------WPFGRFMCKL-N 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 185 SFDVYFST-ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL---------------SPALLSFLPICSGWY 248
Cdd:cd15116   76 SFLLFLNMfTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVvafflsspsfifrdtAPSQNNNKIICFNNF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 249 TTTENYKYLKSNPhiCEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlVYRSKvaalllekhlqisqipKP 328
Cdd:cd15116  156 SLSGDNSSPEVNQ--LRNMRHQVMTITRFLLGFLIPFTIIICCYAAI----------VLKLK----------------RN 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 329 RPSiqveqstistmrRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVG--ILFWIGYFNSALNPIIYAY 406
Cdd:cd15116  208 RLA------------KSSKPFKIIAAVIVTFFLCWAPYHILNLLEMEATRSPASVFKIGlpITSSLAFINSCLNPILYVF 275

                 ....*....
gi 281362294 407 FNRDFRAAF 415
Cdd:cd15116  276 MGQDFKKFK 284
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
116-411 6.28e-09

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 56.74  E-value: 6.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILG---NMLVIVSVMRHRKLRI--ITNYFVVSLAVADMLVALCAMTFNASVMISGkWMFGSVMCDMWNSFDVYF 190
Cdd:cd15122    6 FLLLAALLGlpgNGFIIWSILWKMKARGrsVTCILILNLAVADGAVLLLTPFFITFLTRKT-WPFGQAVCKAVYYLCCLS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPicsgwYTTTENYKYLKSNPHICE-FKVN 269
Cdd:cd15122   85 MYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPA-----FVYRHVWKDEGMNDRICEpCHAS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSM----SFWIPGIVMLSMYyriyqeadrqerlvyrSKVAALLLEkhlqisqipkprpsiqveqstiSTMRRE 345
Cdd:cd15122  160 RGHAIFHYTFetlvAFVLPFGVILFSY----------------SVILVRLKG----------------------ARFRRR 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 346 RKAARTLGIIMSAFLICWLPFflwYIVSSL-CDSCITPRLLVGILFWIG-----------YFNSALNPIIYAYFNRDF 411
Cdd:cd15122  202 ARVEKLIAAIVVAFALLWVPY---HVVNLLqVVANLAPGEVLEKLGGAAkaaragatalaFFSSSVNPLLYVFAAGDL 276
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
116-415 8.79e-09

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 56.37  E-value: 8.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADML--VALCAMTFN-----ASVMISGkWMFGSVMCDMwnsfdv 188
Cdd:cd15101    9 TVCIFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFFagLAYFFLMFNtgpntRRLTVST-WFLRQGLLDT------ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 yFSTASIMHLCCISVDRYYAIVQpLDYPLIMTQRRVFIMLLMVWLSPALLSFLPiCSGWY-----TTTENYKYLKSNPHI 263
Cdd:cd15101   82 -SLTASVANLLAIAVERHISVMR-MQLHSRLSNRRVVVLIVLVWTMAIVMGAIP-SVGWNclcaiDACSNMAPLYSRSYL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 264 cefkvnkAYAIVSSSMSFwipgIVMLSMYYRIYQEADRQERLvyrskvaallLEKHLQisqipkprPSIQVEQSTISTMR 343
Cdd:cd15101  159 -------VFWAISNLVTF----LVMVVVYARIFVYVRRRTNR----------MSPHTS--------GSIRNRDTMMSLLK 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 344 rerkaarTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15101  210 -------TVVIVLGAFVVCWTPGLVVLLLDGLCCRQCNVLAVEKFFLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
116-412 8.95e-09

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 56.45  E-value: 8.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCdMWNSFDVYF-STAS 194
Cdd:cd15081   21 FVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMC-VLEGFTVSVcGITG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDyPLIMTQRRVFIMLLMVWLSPALLSFLPIcSGWYTTTENYKYLKSNPHI---CEFKVNKA 271
Cdd:cd15081  100 LWSLTIISWERWVVVCKPFG-NIKFDGKLAIVGIIFSWVWSAVWCAPPI-FGWSRYWPHGLKTSCGPDVfsgSSDPGVQS 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhLQISQIPkprpsiQVEQSTISTMRRERKAART 351
Cdd:cd15081  178 YMIVLMITCCIIPLAIIILCYLQVW-----------------------LAIRAVA------QQQKESESTQKAEKEVSRM 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 352 LGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15081  229 VVVMIFAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
109-414 1.05e-08

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 55.99  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIIlaaILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcamTFNASVMISGKWMFgSVMCDMW--NSF 186
Cdd:cd15348    5 VAFLAVCAFI---VLENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGA---AYAANILMSGANTL-KLTPALWflREG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFS-TASIMHLCCISVDRYYAIVQPLDYPlIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTtenykylkSNPHICE 265
Cdd:cd15348   78 GVFITlTASVFSLLAIAIERHITMVRMKPYP-GDKRGRMFLLIGAAWLVSILLGVLPIL-GWNCL--------GNLDACS 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 FKV---NKAYAIVSSSMsFWIPGIVMLSMYYRIYQEADRQERLVyrskvaalllekhlqisqipkprPSIQVEQSTISTM 342
Cdd:cd15348  148 TVLplyAKSYILFCITV-FLAILAAIVVLYARIYRIVKANSQRL-----------------------GALPTRKGRARRS 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFW-IGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15348  204 QKYLALLKTVTIVLGTFVACWLPLFLLLLLDVSCPAQACPVLLKADYFLgLAMINSLLNPIIYTLTSRDMRRA 276
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
107-415 1.14e-08

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 56.08  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGFIILAAILgnmLVIVSVMrhrKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGKWMFGSVMCDMWNSF 186
Cdd:cd15155    6 VYSVVFILGLITNCASL---FVFCFRM---KMRNETAIFMTNLAVSDLLF-VFTLPFKIFYNFNRHWPFGDSLCKISGTA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL-------SPALLSFLPICSGWYTTTENYKYLKS 259
Cdd:cd15155   79 FLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWIlvlsggiSASLFSTTNVSNTSTTCFEGFSKSIW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 260 NPHICEFkvnkayAIVSSSMSFWIPGIVMLSMyyriyqeadrqERLVYRSkvaallLEKHLQISQIPKPRpsiqveqsti 339
Cdd:cd15155  159 KTYLSKI------TIFIEVVGFIIPLLLNLTC-----------SSLVLRT------LRKPATLSQIGTNK---------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 340 stmrreRKAARTLGIIMSAFLICWLPF----FLWYIV-SSLCDSCITPRL---LVGILFWIGYFNSALNPIIYAYFNRDF 411
Cdd:cd15155  206 ------EKVLKMILVHVAIFVVCFVPYnsilFLYALVrSQAIANCGVERFartMYPITLCLATLNCCFDPFVYYFTSESF 279

                 ....
gi 281362294 412 RAAF 415
Cdd:cd15155  280 QKSF 283
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
116-412 2.48e-08

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 55.14  E-value: 2.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLvalCAMTFNASVMI---SGKWMFGSVMCDMwNSFDVYFST 192
Cdd:cd15158    9 VITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLL---CVCTLPLRVVYyvhKGQWLFGDFLCRI-SSYALYVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 -ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWY-TTTENYKYLKSNPHICEFKVNK 270
Cdd:cd15158   85 yCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHdTETNKTKCFEPPQSNQQLTKLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskVAALLLEKhlqiSQIPKPRPSiqveqstistmrrERKAAR 350
Cdd:cd15158  165 VLNYISLVVGFIIPFLVILICYAMI---------------IRTLLKNT----MKARKQQSS-------------RKKAIR 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 351 TLGIIMSAFLICWLPFFLWYIV--------SSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15158  213 MIIIVLLAFLVSFMPYHIQRTIhlhflsrkDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFR 282
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
113-414 2.51e-08

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 55.08  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15160    6 VYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNIY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPicsgwyTTTENYKYLKSNPHIC--EFKVNK 270
Cdd:cd15160   86 ASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVF------LGHDELFRDEPNHTLCyeKYPMEG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 AYA---IVSSSMSFWIPGIVMLSMYYRIYQeadrqerlvyrskvaalllekhlqisqipkprpsiQVEQSTISTMRRERK 347
Cdd:cd15160  160 WQAsynYARFLVGFLIPLSLILFFYRRVLR-----------------------------------AVRQSPSLEREEKRK 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 348 AARTLGIIMSAFLICWLPF--------FLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15160  205 IIGLLLSIVVIFLLCFLPYhvvllvrsVIELVQNGLCGFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVRQD 279
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
122-415 2.57e-08

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 54.90  E-value: 2.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 122 ILGNMLVIV---SVMRHRKLRIitNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHL 198
Cdd:cd15926   15 LVGNLLVLYlmkSKQGWKKSSI--NLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMNMYASVFFL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 199 CCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPicSGWYTTTENYkylkSNPHICEFKvnkaYAIVSSS 278
Cdd:cd15926   93 TAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVL-AILASLP--NAIFSTTATV----SNEELCLVK----FPDNRGN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 279 MSFWipgivmLSMYYriyqeaDRQERLVYRSKVAALLLEKHLQISQIPKPRPsiqveqsTISTMRRERKAARTLGIIMSA 358
Cdd:cd15926  162 AQFW------LGLYH------AQKVLLGFLIPLGIISLCYLLLVRFITDKNI-------TGSSTKRRSKVTKSVTIVVLS 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 359 FLICWLP---FFLWYIVSSL------CDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15926  223 FFLCWLPnqaLTTWGILIKLnvvhfsYEYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
116-243 2.60e-08

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 54.91  E-value: 2.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLV-IVSVMRHRKLRIiTNYFVVSLAVAD--------MLVALCAMTFNASVMISGKWMFGSvMCDMWNSF 186
Cdd:cd15136    9 FVFLLALVGNIIVlLVLLTSRTKLTV-PRFLMCNLAFADfcmgiylgLLAIVDAKTLGEYYNYAIDWQTGA-GCKTAGFL 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPI 243
Cdd:cd15136   87 AVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPL 143
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
122-415 2.70e-08

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 54.80  E-value: 2.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 122 ILGNMLVIVSVMRHRKLRIITNYFVVSLAVADML--VALCAMTF----NASVMISGKWMFGSVMCDMwnsfdvyFSTASI 195
Cdd:cd15342   15 LLTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFagVAYLFLMFhtgpWTAKLSLYQWFLRQGLLDT-------SLTASV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQpLDYPLIMTQRRVFIMLLMVWLSPALLSFLPiCSGWYTttenykylksnphICEFKVNKAYAIV 275
Cdd:cd15342   88 ANLLAIAVERHQTIFT-MQLHSKMSNQRVVILIFGIWMVALILGLIP-AMGWNC-------------LCDLKRCSTMAPL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 276 --SSSMSFW-----IPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlQISQIPKPRPsiQVEQSTISTMRrerka 348
Cdd:cd15342  153 ysRSYLVFWalsnlLTFLIMVAVYTRIFIYVRRKSQ----------------RMSEHHSSHP--RYRETVLGLMK----- 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 349 arTLGIIMSAFLICWLPFFLWYIVSSL-CDSCitprllvGILFWIGYF------NSALNPIIYAYFNRDFRAAF 415
Cdd:cd15342  210 --TVVIILGAFVVCWTPGQVVLLLDGLgCESC-------NVLAYEKYFlllaeiNSLVNPIVYSYRDKEMRKTF 274
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
113-408 2.86e-08

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 54.83  E-value: 2.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15385    6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDyPLIMTQRRVFIMLLMVWLSPALLS----FLPICSGWYTTTENYKYLKsnpHICEFKV 268
Cdd:cd15385   86 ASTYMLVMMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWALSFILStpqyFIFSLSEIENGSGVYDCWA---NFIVPWG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIpkprpsiqveqSTISTMRRER-K 347
Cdd:cd15385  162 IKAYITWITISIFVVPVIILLTCYGFICYNIWRNIKCKTRRGLSDNALKNILLAVCV-----------SSVKTISRAKiR 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 348 AARTLGIIMSAFLICWLPFF------LWYIVSSLCDSCITPRLLVGILfwiGYFNSALNPIIYAYFN 408
Cdd:cd15385  231 TVKMTFVIVLAYIVCWAPFFtiqmwsVWDQNFPWDESENTAVTITALL---ASLNSCCNPWIYMFFS 294
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
107-234 2.95e-08

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 54.86  E-value: 2.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGFIilaailGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGKWMFGSVMCDMWNSF 186
Cdd:cd15156    6 VFSMVFVLGLI------ANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVF-TLPFRIFYFVQRNWPFGDLLCKISVTL 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLS 234
Cdd:cd15156   79 FYTNMYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLT 126
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
132-243 3.12e-08

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 54.37  E-value: 3.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 132 VMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISG-KWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIV 210
Cdd:cd15372   24 VLATQVKRLPSTIFLINLAVADLLLIL-VLPFKISYHFLGnNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVV 102
                         90       100       110
                 ....*....|....*....|....*....|...
gi 281362294 211 QPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPI 243
Cdd:cd15372  103 HPFFARTLRSRRFALCMCTAIWLI-AAALTLPL 134
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
113-243 3.28e-08

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 54.38  E-value: 3.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCaMTFNASVMISG-KWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15162    6 VYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIW-LPFKIAYHIHGnNWIFGEALCRLVTVAFYGNM 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPI 243
Cdd:cd15162   85 YCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLL-ALLVTLPL 135
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
116-415 3.51e-08

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 54.33  E-value: 3.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVAlCAMTFNAS-VMISGKWMFGSVMCDMWnSFDVYFST-A 193
Cdd:cd15157    9 IIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFV-STLPFRADyYLMGSHWVFGDIACRIM-SYSLYVNMyC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 194 SIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICE--FKVNKA 271
Cdd:cd15157   87 SIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLLSKGTSKYNSQTKCLDLHPSKIDklLILNYI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 272 YAIVSSSMSFWIpgivmLSMYYriyqeadrqerlvyrskvaaLLLEKHLQISQIPKPRPSIQveqstistmrrERKAART 351
Cdd:cd15157  167 VLVVGFILPFCT-----LSICY--------------------ILIIKALLKPRVPQSKLRVS-----------HKKALLT 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 352 LGIIMSAFLICWLPFFLW---YIVSSLCDSCITP--RLLVgILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15157  211 IIITLILFLLCFLPYHILrtvHLMQWSEGQCNLRlhKAVV-ITLCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
116-413 3.67e-08

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 54.45  E-value: 3.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15077    9 FLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDyPLIMTQRRVFIMLLMVWLSPALLSFLPI------------CS---GWYTTTENYKylksn 260
Cdd:cd15077   89 WSLAVVAFERFLVICKPLG-NFTFRGTHAIIGCIATWVFGLAASLPPLfgwsryipeglqCScgpDWYTTNNKWN----- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 261 phicefkvNKAYAIVSSSMSFWIPGIVMLSMYYRiyqeadrqerlvyrskvaaLLLEKHLQISQipkprpsiqvEQSTIS 340
Cdd:cd15077  163 --------NESYVMFLFCFCFGVPLSIIVFSYGR-------------------LLLTLRAVAKQ----------QEQSAS 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 341 TMRRERKAARTLGIIMSAFLICWLPF--FLWYIVSSLCDSciTPRLLVGILFWIGYFNSALNPIIYAYFNRDFRA 413
Cdd:cd15077  206 TQKAEREVTKMVVVMVLGFLVCWLPYasFALWVVTNRGEP--FDLRLASIPSVFSKASTVYNPVIYVFMNKQFRS 278
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
102-239 4.87e-08

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 54.03  E-value: 4.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 102 SHLALVFVKCFIIGfiilaaILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISgKWMFGSVMCD 181
Cdd:cd15187    1 LFLPVLYCLLFVFG------LLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVF-SLPFQAYYLLD-QWVFGNAMCK 72
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 182 MWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS 239
Cdd:cd15187   73 IVSGAYYIGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILAS 130
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
113-414 5.17e-08

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 54.11  E-value: 5.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVsVMRHRKLRIIT--NYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15925    6 AYGLVCAIGLLGNLAVMY-LLRNCARRAPPpiDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTATVLN 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPIcSGWYTTTEnykYLKSNPHICEFKVNK 270
Cdd:cd15925   85 VYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAA-ALLATVPT-AIFATEGE---VCGVELCLLKFPSNY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 271 ---AYAIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrskvaaLLLEKHLQISQIPKPRPsiqveqstistmRRERK 347
Cdd:cd15925  160 wlgAYHLQRVVVAFVVPLGVITTSY---------------------LLLLSFLQQHKVNQNNR------------QRQSV 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 348 AARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITP---------RLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15925  207 IARSVRLVVASFFLCWFPNHVVTFWGVLVKFRAVPwnstfyfihTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQA 282
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
122-415 5.76e-08

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 53.88  E-value: 5.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 122 ILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTF------NASVMISGKWMFGSVMCDMwnsfdvyFSTASI 195
Cdd:cd15344   15 MLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLmfntgpNTRRLTVSTWLLRQGLIDT-------SLTASV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQpLDYPLIMTQRRVFIMLLMVWLSPALLSFLPiCSGWYTttenykylksnphICEFKV--NKAYA 273
Cdd:cd15344   88 ANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIP-SVGWNC-------------ICDIENcsNMAPL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 274 IVSSSMSFW-----IPGIVMLSMYYRIYQE-ADRQERLvyrskvaalllEKHLQisqipKPRPSIQVEQSTIstmrrerk 347
Cdd:cd15344  153 YSDSYLVFWaifnlVTFVVMVVLYAHIFGYvRQRTMRM-----------SRHSS-----GPRRNRDTMMSLL-------- 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 348 aaRTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFwIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15344  209 --KTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLL-LAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
107-410 9.87e-08

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 52.96  E-value: 9.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIiGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADML--VALCAMTFN----ASVMISGKWMFGSVMC 180
Cdd:cd15343    1 IIVLCVG-TFCCLFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFagIAYVFLMFNtgpvSKTLTVNRWFLRQGLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 181 DMwnsfdvyFSTASIMHLCCISVDRYYAIVQpLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTttenykylksn 260
Cdd:cd15343   80 DT-------SLSASLTNLLVIAVERHISIMR-MKVHSNLTKRRVTLLIALVWAIAIFMGAVPTL-GWNC----------- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 261 phICEFKVNKAYAIV--SSSMSFW-----IPGIVMLSMYYRIYQEADRQerlvyrskvaalllekhlqiSQIPKPRPSiq 333
Cdd:cd15343  140 --ICNISACSSLAPIysRSYLVFWsvsnlVVFLIMVVVYLRIYVYVQRK--------------------TNVLSPHTS-- 195
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 334 veqSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSL-CDSCITPRLLVGILFwIGYFNSALNPIIYAYFNRD 410
Cdd:cd15343  196 ---GSINRRRTPIKLMKTVMTVLGAFVICWTPGLVVLLLDGLnCTRCGVQHVKRWFLL-LALLNSVMNPIIYSYKDEE 269
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
112-310 1.16e-07

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 52.77  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVI---VSVMRHRKLRIITNyfvVSLAVADMLVaLCAMTFNASVMISGK-WMFGSVMCDmWNSFD 187
Cdd:cd15375    5 VMYSIIFIVGFPGNIIAIfvyLFKMRPWKSSTIIM---LNLALTDLLY-VTSLPFLIYYYINGEsWIFGEFMCK-FIRFI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFST-ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPIcsGWYTTTENykylKSNPHIC-- 264
Cdd:cd15375   80 FHFNLyGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVI-SLAEVSPM--TFLITTKE----KNNRTICld 152
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 281362294 265 -----EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADR--QERLVYRSK 310
Cdd:cd15375  153 ftssdNLNTIWWYNWILTVLGFLLPLVIVTLCYTRIIYTLAKgpHTGSASKQK 205
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
111-415 1.19e-07

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 52.90  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAA--ILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcamTFNASVMISGKWMFgSVMCDMW----N 184
Cdd:cd15345    2 LTTIFFLVICSfiVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGI---AYKVNILMSGKKTF-SLSPTQWflreG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 185 SFDVYFStASIMHLCCISVDRYYAIVQPLDYPlIMTQRRVFIMLLMVWLSPALLSFLPICsGWYTTtenykylkSNPHIC 264
Cdd:cd15345   78 SMFVALG-ASTFSLLAIAIERHLTMIKMRPYD-ANKRYRVFLLIGTCWLISVLLGALPIL-GWNCL--------DNLPDC 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 EFKV---NKAYAIVSSSMsFWIPGIVMLSMYYRIYQEADRQERLVYRSkvaalllekhlqisqipkpRPSiqveqstist 341
Cdd:cd15345  147 STILplySKKYVAFCISI-FIAILVAIVILYARIYILVKSSSRRVTNH-------------------RNS---------- 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 342 mRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFW-IGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15345  197 -ERSMALLRTVVIVVGVFIACWSPLFILLLIDVACEVKQCPILYKADWFIaLAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
112-412 1.29e-07

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 52.79  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVvSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15114    5 VLYAVVFLVGVPGNALVAWVTGFEAKRSVNAVWFL-NLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLILLNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPicSGWYTTTENYKYlkSNPHIC------E 265
Cdd:cd15114   84 YASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLL-ALLLTVP--SFIYRRIHQEHF--PEKTVCvvdyggS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 FKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRqerlvyrskvaalllekhlqisqipkprpsiqveqstistmRRE 345
Cdd:cd15114  159 TGVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWS-----------------------------------------RRR 197
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 346 RKAARTLGIIMSA---FLICWLPFFL--WYIVSSLCDSCITPRLLVG--ILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15114  198 QKSRRTLKVVTAVvvgFFLCWTPYHVvgLIIAASAPNSRLLANALKAdpLTVSLAYINSCLNPIIYVVAGRGFR 271
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
116-239 2.23e-07

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 51.87  E-value: 2.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVA------LCAMTFNASVMISgkwmFGSVMCDMWnsFDVY 189
Cdd:cd15232    9 FLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTstvvpkLLQNLLTERKTIS----FGGCMAQLY--FFTW 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 281362294 190 FSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS 239
Cdd:cd15232   83 SLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNS 132
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
107-234 2.30e-07

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 52.17  E-value: 2.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGFIILAAilGNMLVIVSVMRHRKLRII---TNYFVVSLAVADMLVALCAMTFN--ASVMISGKWMFGSVMCD 181
Cdd:cd15356    2 LFTAVYALIWALGAA--GNALTIHLVLKKRSLRGLqgtVHYHLVSLALSDLLILLISVPIElyNFVWFHYPWVFGDLVCR 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 281362294 182 MWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLS 234
Cdd:cd15356   80 GYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWAS 132
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
116-241 2.46e-07

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 51.68  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADmlvaLCAMtfnaSVMISgKWMFGSVMCDMWNSFD-------- 187
Cdd:cd15227    9 LIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLD----LCYI----SVTVP-KSIANSLTNTRSISFLgcvaqvfl 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 188 -VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFL 241
Cdd:cd15227   80 fIFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGAL 134
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
116-415 2.51e-07

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 51.77  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFsTASI 195
Cdd:cd15211    8 FLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGTLLVLGYRLFREGLLFLGL-TVSL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQ-PLDYPLIMTQRRVFIMLLMVWLSPaLLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYAI 274
Cdd:cd15211   87 LSHSLIALNRYVLITKlPAVYQALYQKRNTEWMIALSWALA-LGLLLPWLTSFRYPTKSCHDSADGSFAVVSVLSSRYPA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 275 VSSSMSFWIPGIVMLSMYYRIYQEADrqerlVYRSKVAALLLEKhlqISQIPKPRPsiqveqstistmRRERKAARTLGI 354
Cdd:cd15211  166 LLLAFTVLGQTALVLHCYFGIFRRVQ-----ISVKRVSVLNFQI---VNNLPYSRP------------RKDKRLGLYVLL 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 355 IMSAFLICWLPFFlWYIVSSLCDSciTPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15211  226 VCCVFLLTTEPLV-WVSLAGLFVP--VPVALQTASWLLFCTLFVLNPFLYTWKNEEFRRSF 283
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
117-415 2.73e-07

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 51.70  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd14988   10 IFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFANMYSSIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICsgwyttteNYKYLKSNPHIC----EFKVNKAY 272
Cdd:cd14988   90 FLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVV--------HMQLLDGVEPMClflaPFETYDEW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 273 AIvSSSMSFWIPGIvmlsmyyriyqeadrqerLVYRSKVAALLLEKHLQISQIPKPrpsiqveqstistmrRERKAARTL 352
Cdd:cd14988  162 AL-AVSLLTLIIGF------------------LIPFSIIAVFNVLTARYIRTAGRP---------------ESRRHCLLI 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLCDSCITPRL-LVGILFW-------IGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd14988  208 YAYILVFVVCWLPYHVTLLLLTLHGSHISLHCnLVHFLYFfydvidcFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
112-412 3.40e-07

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 51.30  E-value: 3.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWN---SFDV 188
Cdd:cd14987    5 FFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHlifSINL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YfstASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPicsgwytttENYkYLK--SNPHICEF 266
Cdd:cd14987   85 F---GSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLL-AFVASLP---------DTY-FLKtvTSPSNNET 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIvsSSMSFWIPGIVMLSMyyriyqeadrqerlvyrskVAALLLekhlqisqipkPRPSIQVE----QSTIS-T 341
Cdd:cd14987  151 YCRSFYPE--ESFKEWLIGMELVSI-------------------VLGFVI-----------PFPIIAVFyfllARAISaS 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 342 MRRERKAARTlgIIMS---AFLICWLPFF------LWYIVSSLCDSCITPRLLVGILF---WIGYFNSALNPIIYAYFNR 409
Cdd:cd14987  199 SDQERKSSRK--IIFSyvvVFLVCWLPYHtvvlldILSFLHLIPFSCQLENFLYAALHvtqCFSLVHCCVNPILYSFINR 276

                 ...
gi 281362294 410 DFR 412
Cdd:cd14987  277 NYR 279
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
117-415 3.96e-07

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 51.37  E-value: 3.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMF-----GSVMCDMWNSFDVYFS 191
Cdd:cd15128   10 IFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFgdqpfGQFLCKLVPFIQKASV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAI-----VQPLDYPLIMTqrrvfIMLLMVWLSPALLSfLPICSGWYTTTENYKylKSNPHICEF 266
Cdd:cd15128   90 GITVLNLCALSVDRYRAVaswsrIQGIGIPMWTA-----VEIVMIWMLSAVLA-VPEAIGFDMVRFNYK--GVTLRTCLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAY-AIVSSSMSFWIPG------IVMLSMYYRIYQeadrQERLVYRSKVAALLLEKHlqisqipkprpsiqveqsti 339
Cdd:cd15128  162 RPETSFmKFYIDVKDWWLFGfyfclpLVCTAIFYTLMT----CEMLRKRNGMLRIALNEH-------------------- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 340 stMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRL--LVGILFWIGYF-------NSALNPIIYAYFNRD 410
Cdd:cd15128  218 --LKQRREVAKTVFCLVVIFALCWLPLHLSRILKLTVYDQNDPNRceLLSFLLVLDYFginlatlNSCINPIALYFVSRK 295

                 ....*
gi 281362294 411 FRAAF 415
Cdd:cd15128  296 FKNCF 300
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
112-244 4.55e-07

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 50.95  E-value: 4.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCA---MTFNasvMISGKWMFgSVMCDMWNSFd 187
Cdd:cd15912    4 FLLLLLTyLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVipkMLAN---LLSGKKTI-SFAGCFAQSF- 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 188 VYFS--TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIC 244
Cdd:cd15912   79 FYFFlgTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTI 137
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
116-242 4.68e-07

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 51.35  E-value: 4.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYF--VVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTA 193
Cdd:cd15142    9 VMFIFGVVGNLIAIVVLCKSRKEQKETTFYtlVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILLFFSLS 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 281362294 194 SIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLP 242
Cdd:cd15142   89 GLSIICAMSIERYLAINHAYFYNHYVDKRLAGLTLFAIYASNILFCALP 137
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
112-412 5.23e-07

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 50.91  E-value: 5.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIilaailGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMiSGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15184   11 FIFGFV------GNMLVVLILINCKKLKSMTDIYLLNLAISDLLF-LLTLPFWAHYA-ANEWVFGNAMCKLLTGLYHIGF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYTTTENYKYLKSN--PHICEFKVN 269
Cdd:cd15184   83 FSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVV-AVFASLPGIIFTKSQKEGSHYTCSPhfPPSQYQFWK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 KAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERlvyrskvaalllekhlqisqipkprpsiqveqstistMRRERKAA 349
Cdd:cd15184  162 NFQTLKMNILGLVLPLLVMIICYSGILKTLLRCRN-------------------------------------EKKRHKAV 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 350 RTLGIIMSAFLICWLPFFLWYIVSSL-----CDSC-ITPRLLVG--ILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15184  205 RLIFTIMIVYFLFWAPYNIVLLLNTFqeffgLNNCsSSNRLDQAmqVTETLGMTHCCINPVIYAFVGEKFR 275
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
104-415 5.31e-07

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 50.94  E-value: 5.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 104 LALVFVKCFIIGFIilaailGNMLVIvSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMW 183
Cdd:cd15120    3 IAVALFVTFLVGLV------VNGLYL-WVLGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 184 NSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLP---------------ICSGWY 248
Cdd:cd15120   76 NSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLS-IPylafretrldekgktICQNNY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 249 TTTENykYLKSNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRiyqeadrqerlvyrskVAALLLEKHLQisqipkp 328
Cdd:cd15120  155 ALSTN--WESAEVQASRQWIHVAMFVFRFLLGFLLPFLIITFCYVR----------------MALKMKERGLA------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 329 rpsiqveqstistmrRERKAARTLGIIMSAFLICWLPFFLWY---IVSSLCDSCITPRLLVGILFWIgyFNSALNPIIYA 405
Cdd:cd15120  210 ---------------RSSKPFKVMFTAVVSFFVCWLPYHLHSglvLTRGRPPSLTDITLLLTVGTTC--FNTCFTPVLYL 272
                        330
                 ....*....|
gi 281362294 406 YFNRDFRAAF 415
Cdd:cd15120  273 FVGENFKKVL 282
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
124-239 6.17e-07

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 50.72  E-value: 6.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 124 GNMLVIVSVMRHRKLRIITN---YFVVSLAVADMLVALCAMTFN--ASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHL 198
Cdd:cd15130   17 GNSVTLFTLARKKSLQSLQStvrYHLGSLALSDLLILLLAMPVElyNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNV 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 281362294 199 CCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS 239
Cdd:cd15130   97 ASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLA 137
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
111-244 6.56e-07

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 50.29  E-value: 6.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADmlvaLCAMTFNASVMISGKWM------FGSVMCDMW 183
Cdd:cd15939    3 CFVVFLLIyLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFID----ICYSSTTAPKLIVDLLSerktisFNGCMTQLF 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 184 nsFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIC 244
Cdd:cd15939   79 --AEHFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQIL 137
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
117-302 6.56e-07

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 50.53  E-value: 6.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRI-ITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15219    9 VLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAM 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLK-SNPHICEFKVNKAYAI 274
Cdd:cd15219   89 LSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLGYSSLYASCTlHLPREEERRRFAVFTA 168
                        170       180
                 ....*....|....*....|....*...
gi 281362294 275 VSSSMSFWIPGIVMLSMYYRIYQEADRQ 302
Cdd:cd15219  169 FFHAFTFLLSLLVLCVTYLKVLKVRRRQ 196
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
108-412 6.69e-07

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 50.59  E-value: 6.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLvaLCAMTFNASVMISGKWMFGSVMCDMWNSFD 187
Cdd:cd14989    1 FLSCLYTIFLFPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLI--LVADSLIEVFNLNEKYYDIAVLCTFMSLFL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTenykylkSNPHICeFK 267
Cdd:cd14989   79 QINMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHT-------GEVHFC-FA 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSSSMSFWIPGIVM---LSMYYRIYQEADRQERLvyrskvaalllekhlqisqipkpRPsiqveqstistmrR 344
Cdd:cd14989  151 DVREIQWLEVTLGFIIPFSIIglcYSLIVRVLVRAQKHRRL-----------------------RP-------------R 194
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 345 ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCD----SCITPR-------LLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd14989  195 RQKALRMILVVVLVFFICWLPENVFISIQLLQGtqepSESYDEsfrhnhpLTGHIVNLAAFSNSCLNPLIYSFLGETFR 273
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
112-415 7.44e-07

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 50.51  E-value: 7.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIIlaAILGNMLVIvSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMwNSFDVYFS 191
Cdd:cd15119    7 YIVAFVL--GVPGNAIVI-WVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKI-NSFVAVLN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 T-ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS-----FLPICSGWYTTTENYK-YLKSNPHIC 264
Cdd:cd15119   83 MfASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISgpalyFRDTMELSINVTICFNnFHKHDGDLI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 EFKVNkAYAIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrskvaALLLekhlqisqipkprpsIQVEQSTISTMrr 344
Cdd:cd15119  163 VMRHT-ILVWVRFFFGFLFPLLTMVVCY--------------------SLLA---------------IKVKRRTLLIS-- 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 345 eRKAARTLGIIMSAFLICWLPFFLWYI--VSSLCDSCITPRLLVGILFW--IGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15119  205 -SKFFWTISAVIVAFFVCWTPYHIFSIleLSIHHSSYLHNVLRAGIPLAtsLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
109-414 8.56e-07

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 50.17  E-value: 8.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASvMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd14975    2 LGCTLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYF-LATGTWDFGLAACKGCVYVCA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSgwYTTTEnykyLKSNPHICEFKV 268
Cdd:cd14975   81 VSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLA-TPVIA--FRHVE----ETVENGMCKYRH 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 269 NK-----AYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQerlvyrskvaalllekhlqisqipkprpsiqveqstisTMR 343
Cdd:cd14975  154 YSdgqlvFHLLLETVVGFAVPFTAVVLCYSCLLRRLRRR--------------------------------------RFR 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 344 RERKAARTLGIIMSAFLICWLPFFLWYI--VSSLCDSCITPRLLVG--------ILFWIGYFNSALNPIIYAYFNRD-FR 412
Cdd:cd14975  196 RRRRTGRLIASVVVAFAACWLPYHVGNLleVVSELIGGSKMAGTLGkvaeagrpIAGALAFLSSSINPLLYAFAARGlFR 275

                 ..
gi 281362294 413 AA 414
Cdd:cd14975  276 SA 277
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
108-241 8.60e-07

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 50.78  E-value: 8.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAaILGNMLVIVsVMRHRKLRIITNYFVVSLAVADML--VALCAMTFNAsvmiSGKWMFGSVMCDMWnS 185
Cdd:PHA02638 100 YIKIFYIIIFILG-LFGNAAIIM-ILFCKKIKTITDIYIFNLAISDLIfvIDFPFIIYNE----FDQWIFGDFMCKVI-S 172
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 186 FDVYFSTASIMHLCCI-SVDRYYAIVqpldYPLIMTQRRVFIMLLMVWLSPALLSFL 241
Cdd:PHA02638 173 ASYYIGFFSNMFLITLmSIDRYFAIL----YPISFQKYRTFNIGIILCIISWILSLI 225
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
112-244 1.02e-06

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 49.79  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNML-VIVSVMRHRKLR-IITNYFVVSLAVADMLvaLCAM-TFNASVMISGK-WMFGSVMCDMWNSFD 187
Cdd:cd15371    2 LIPAVYIIVVVLGVPSnAIILWMLFFRLRsVCTAIFYANLAISDLL--FCITlPFKIVYHLNGNnWVFGETMCRIITITF 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPIC 244
Cdd:cd15371   80 YGNMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTI-VFLYMLPFF 135
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
104-404 1.10e-06

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 50.08  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 104 LALVFVKCFIIGFiilaaiLGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCaMTFNASVMISG-KWMFGSVMCDM 182
Cdd:cd15148    3 LAVFYSLIFLFGL------VGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIIC-LPFRILYHVNNnQWTLGPLLCKV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 183 WNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWlSPALLSFLPICSgwyTTTENykylkSNPH 262
Cdd:cd15148   76 VGNLFYMNMYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLW-AVALVGFVPMIV---LTEKN-----EEST 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 IC-EFK-----VNKAYAIVSSSMSFWIPGIVMLSMYYRIYQeadrqerlvyrskvaallleKHLQISQipkprpsiqvEQ 336
Cdd:cd15148  147 KCfQYKdrknaKGKAIFNFLIVAMFWLVFLLLILSYGKIAK--------------------KLLRISR----------DK 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 337 STISTMRRERKAARTLGIIMSAFLICWLP---FFLWYIVSSLCD-SCITPRLLVG---ILFWIGYFNSALNPIIY 404
Cdd:cd15148  197 PDFPNAAKYNRTARKSFFVLFIFTVCFVPyhaFRIFYITSQLQNnSCYWKEILHKtneIMLLLSAFNSCLDPVMY 271
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
108-415 1.45e-06

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 49.52  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFD 187
Cdd:cd15977    1 YVNTILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFSTASIMHLCCISVDRYYAI-----VQPLDYPLimtqrRVFIMLLMVWLSPALLSfLPICSGWYTTTENYKylKSNPH 262
Cdd:cd15977   81 KASVGITVLSLCALSIDRYRAVaswsrIRGIGIPV-----WKAVEVTLIWAVAIIVA-VPEAIAFDMVEIDYR--GQTLL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 ICEFKVNKAyaivSSSMSF-------WIPG------IVMLSMYYRIYqeadrQERLVYRSKVAALLLEKHlqisqipkpr 329
Cdd:cd15977  153 VCMLPMEQT----SSFMRFyqdvkdwWLFGfyfclpLACTGVFYTLM-----SCEMLSIKNGMRIALNDH---------- 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 330 psiqveqstistMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPR--LLVGILFWIGYF-------NSALN 400
Cdd:cd15977  214 ------------MKQRREVAKTVFCLVVIFALCWLPLHLSRILKKTIYDVKDPQrcELLSFLLVMDYTginmaslNSCIN 281
                        330
                 ....*....|....*
gi 281362294 401 PIIYAYFNRDFRAAF 415
Cdd:cd15977  282 PVALYFVSRKFKNCF 296
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
103-233 1.48e-06

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 49.52  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 103 HLALVFVKCFIIGFiilaaiLGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDM 182
Cdd:cd15377    2 YLPAVYILVFITGF------LGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKL 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 281362294 183 WNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL 233
Cdd:cd15377   76 QRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWL 126
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
107-233 1.67e-06

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 49.38  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGFIILAAILgNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGK-WMFGSVMCDMWNS 185
Cdd:cd15369    1 RFVPSVYTIVFVISLPL-NILALVVFLRKMRVKKPAVIYMLNLACADLLFVL-LLPFKIAYHFSGNdWLFGEAMCRVVTA 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 281362294 186 FDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL 233
Cdd:cd15369   79 AFYCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWL 126
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
113-411 1.80e-06

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 49.42  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNmLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFST 192
Cdd:cd15118    6 LHGIVSTLGIVEN-LLILWVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSF--------LPICSGWYTTTENYKYLKSNPH-- 262
Cdd:cd15118   85 VSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIpyfvfrdvIERKDGRKLCYYNFALFSPSPDnn 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 --ICEFKvNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerlvyrskvaalllekHLQISQIPKPRPSiqveqstis 340
Cdd:cd15118  165 hpICKQR-QEGLAISKLLLAFLIPLVIIAVSYAVV-----------------------SLIIRHRCRRRPG--------- 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 341 tmrrerKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVG----ILFWIGYFNSALNPIIYAYFNRDF 411
Cdd:cd15118  212 ------RFVRLVVSVVVSFALCWAPYHIFSIIEVMAHNQHSLRPLVIqglpFATTLAFLNSVLNPVLYVFSCPDF 280
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
112-297 2.16e-06

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 49.01  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCD-----MWNSF 186
Cdd:cd15365    5 FVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIfsaflLYTNF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 dvYFSTAsimHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLspallsfLPICSGWYTTTENYKYLKSNPHICEF 266
Cdd:cd15365   85 --YTSTA---LLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWL-------LEICFNAVILTWEDSFHESSSHTLCY 152
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 281362294 267 ------KVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQ 297
Cdd:cd15365  153 dkfpleDWQARLNLFRICLGYLLPLLIILFCYWKIYQ 189
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
112-412 3.19e-06

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 48.65  E-value: 3.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAilgNMLVIVSVMRHRKlriITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFS 191
Cdd:cd15374   11 FVVGLPLNAT---ALWLFIKRMRPWN---PTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYANL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSflpICSGWYTTTENykylKSNPHIC------- 264
Cdd:cd15374   85 YCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCL---VPNLIFVTTSR----KDNITLChdttrpe 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 265 EFKVNKAYAIVSSSMSFWIPGIVMLSMYyriyqeadrqerlvyrskvaalllekHLQISQIPKPRPSIQVEQSTISTMRr 344
Cdd:cd15374  158 EFDHYVHYSSAVMVLLFGIPCLVIVVCY--------------------------GLMARRLCKPRVGSSRQQGPSSKKR- 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 345 erkAARTLGIIMSAFLICWLPFF----LWYIVSSLCDSCITPRLL---VGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15374  211 ---SLKTIIMVLTVFAICFVPFHitrtLYYVARLLKADCDTLNIInvtYKVTRPLASANSCLDPILYFLAGDKYR 282
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
111-240 3.55e-06

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 48.21  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAIL--GNMLVIVSVMRHRKLRIITNYFVVSLAVADmlvaLCAMTFNASVMISGKWM------FGSVMCDM 182
Cdd:cd15940    2 AFFMLFLVLYLLTlsGNILIMITIVMDPRLHTPMYFFLSNLSFID----ICHSSVTVPKMLSDLLSeektisFNGCVTQL 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 183 WnsFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSF 240
Cdd:cd15940   78 F--FLHLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSL 133
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
104-295 5.07e-06

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 47.73  E-value: 5.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 104 LALVFVKCFIIGFiilaaiLGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISG-KWMFGSVMCDM 182
Cdd:cd15159    3 LPLFYSLILVFGL------LGNTLALHVICQKRKKINSTTLYLINLAVSDILFTL-ALPGRIAYYALGfDWPFGDWLCRL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 183 wNSFDVYFST-ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICS--------GWYTTTE- 252
Cdd:cd15159   76 -TALLFYINTyAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVL-VFLQTLPLLFmpmtkemgGRITCMEy 153
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 281362294 253 -NYKYLKSNPHICefkvnkayaIVSSSMSFWIPGIVMLSMYYRI 295
Cdd:cd15159  154 pNFEKIKRLPLIL---------LGACVIGFGVPVGIILFCYSQI 188
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
116-412 5.46e-06

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 47.95  E-value: 5.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGK---WMFGSVMCDMWNSFDVYFST 192
Cdd:cd15006    8 VIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHccwWIYTLLFCKVIKFLHKVFCS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRR---VFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHIcefkvn 269
Cdd:cd15006   88 VTVLSFAAIALDRYYSVLYPLERKISDAKSRdlvIYIWAHAVVASVPVFAVTNVTDIYAMSTCTESWGYSLGHL------ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 270 kAYAIVSSSMSFWIPGIVMLsmyyriyqeadrqerlvyrskVAALLLEKHLQISQIPKP-RPSIQVEQSTIS---TMRRE 345
Cdd:cd15006  162 -VYVIIYNITTVILPVAVVF---------------------LFMILIRRALSASQKKKViIAALRTPQNTISipyVSQRE 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 346 RKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFR 412
Cdd:cd15006  220 AELHAMLLSMVLVFILCSVPYATLVIYRTILNISDISVFLLLTAIWLPKVSLLANPLLFLTVNKSVR 286
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
117-415 6.75e-06

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 47.55  E-value: 6.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMF-----GSVMCDMWNSFDVYFS 191
Cdd:cd15975   10 IFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFddssfGVFLCKLVPFLQKASV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 TASIMHLCCISVDRYYAI-----VQPLDYPLIMTqrrvfIMLLMVWLSPALLSfLPICSGWYTTTenYKYLKSNPHICEF 266
Cdd:cd15975   90 GITVLNLCALSVDRYRAVaswsrVQGIGIPLITA-----IEIFSIWVLSFILA-IPEAIGFVMVP--FEYNGEQYRTCML 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVNKAYAIVSSSMS-FWIPG------IVMLSMYYRIYQeadrQERLVYRSKVAALLLEKHLqisqipkprpsiqveqsti 339
Cdd:cd15975  162 NATTKFMNFYVDAKdWWLFGfyfcvpLACTAIFYTLMT----CEMLNRRKGSLRIALSEHL------------------- 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 340 stmRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRL--LVGILFWIGYF-------NSALNPIIYAYFNRD 410
Cdd:cd15975  219 ---KQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNENDPRRceLLSFLLVMDYIsinlatmNSCINPIALYFVSKK 295

                 ....*
gi 281362294 411 FRAAF 415
Cdd:cd15975  296 FKNCF 300
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
112-239 1.07e-05

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 46.70  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15428    4 FILFLIIyLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSF 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS 239
Cdd:cd15428   84 GITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVS 132
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
107-239 1.40e-05

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 46.36  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIgFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISGkWMFGSVMCDMWNSF 186
Cdd:cd15186    1 IFLSIFYS-LVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLF-VATLPFWTHYLINE-WGLHNAMCKLTTAF 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS 239
Cdd:cd15186   78 FFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVA 130
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
121-415 1.43e-05

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 46.32  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 121 AILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCaMTFNASVMISG-KWMFGSVMCDMWNSFDVYFSTASIMHLC 199
Cdd:cd15199   14 GLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLIC-LPFKAYFYLNGnRWSLGGGTCKALLFMLSLSRGVSIAFLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 200 CISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLspaLLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYAIVSSSM 279
Cdd:cd15199   93 AVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWL---LLVGLTIPTLLASQPKNFTECNSFSPKDDEDFSDTWQEAVFFL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 280 SFWIPGIVMLSMYYRIYQEadrqerlvyrskvaalLLEKHLQISQIPKprpsiqveqstistmrrERKAARTLGIIMSAF 359
Cdd:cd15199  170 QFLLPFGLIVFCTVRIIRR----------------LKKRLRDVGKQPK-----------------LQRAMALVTSVVVVF 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 360 LICWLPFFLWYIVSSL---CDSCITPRLLV---GILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15199  217 GFCFLPCFLARVLMLIfqnKESCNALNIAVhtyDVTMCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
112-244 1.51e-05

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 46.17  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADmlvaLCAMTFNASVMISGKWM------FGSVMCDMWn 184
Cdd:cd15936    4 FLVFLLVyLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLD----ISFSSVTAPKMLSDLLSqtktisFNGCMAQMF- 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 185 sFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSP--------ALLSFLPIC 244
Cdd:cd15936   79 -FFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGfahsivqvALLLQLPFC 145
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
116-241 1.88e-05

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 46.06  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVAD----------MLVALcamtFNASVMISgkwmFGSVMCDMWns 185
Cdd:cd15235   10 AMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDicftsttvpkMLANL----LSGSKTIS----YAGCLAQMY-- 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 186 FDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFL 241
Cdd:cd15235   80 FFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLL 135
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
104-412 1.91e-05

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 46.02  E-value: 1.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 104 LALVFVKCFIIGFIIlaailgNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVA--LCAMTFNASVmiSGKWMFGSVMCD 181
Cdd:cd15379    3 LPLVYSVVFLLGLPL------NAVVIGQIWATRQALSRTTIYMLNLATADLLYVcsLPLLIYNYTQ--KDYWPFGDFTCR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 182 MWNsFDVYFST-ASIMHLCCISVDRYYAIVQPL-DYPLIMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTTENYK---Y 256
Cdd:cd15379   75 LVR-FQFYTNLhGSILFLTCISVQRYLGICHPLaSWHKKKGKKLTWLVCGAVWLVVIAQC-LPTFVFASTGTQRNRtvcY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 257 LKSNPHICEFKVnkAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAAlllekhlqisqipkprpsiqveq 336
Cdd:cd15379  153 DLSPPARSTAYF--PYGITLTRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPG----------------------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 337 stistmRRERKAARTLGIIMSAFLICWLPFFL----WYIVSSLCDSCITPRLlvgiLFWIGY--------FNSALNPIIY 404
Cdd:cd15379  208 ------EKRGKAARMIIVVAAVFLISFLPFHYtktrYLQVRSWDGGPCTTRQ----AFAEAYkrtrpfasMNSVLDPILF 277

                 ....*...
gi 281362294 405 AYFNRDFR 412
Cdd:cd15379  278 YFTQSKFR 285
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
112-306 2.30e-05

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 45.86  E-value: 2.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIilaailGNMLVIVSVMRHRKLRIITNYFVVSLAVADmLVALCAMTFNASVMISGKWMFGSVMCDMwNSFDVYFS 191
Cdd:cd15378   11 FVLGFI------GNTIVILGYIFCLKNWKSSNIYLFNLSVSD-LAFLCTLPMLVYSYSNGQWLFGDFLCKS-NRYLLHAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 T-ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVW------LSPALLSFLPICSGWYTTTENYKYLKsnphic 264
Cdd:cd15378   83 LySSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWvlvtleLLPILTFIGPNLKDNVTKCKDYASSG------ 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 281362294 265 EFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLV 306
Cdd:cd15378  157 DATNSLIYSLFLTVTGFLIPLCVMCFFYYKIALFLKNRNRQL 198
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
111-243 2.36e-05

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 45.55  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVA------LCAMTFNASVMISgkwmFGSVMCDMW 183
Cdd:cd13954    3 LFVLFLLIyLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTsvtvpkMLANLLSGDKTIS----FSGCLTQLY 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 184 nsFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPI 243
Cdd:cd13954   79 --FFFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHT 136
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
117-232 3.05e-05

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 45.53  E-value: 3.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15154   10 LFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTL-SLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGSCL 88
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVW 232
Cdd:cd15154   89 FLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVW 124
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
113-412 3.65e-05

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 45.28  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVI-VSVMRHRKLRiITNYFVVSLAVADMLVALCAMTFnASVMISGK---------WMFGSvMCDM 182
Cdd:cd15964    6 VVWFVNLLAILGNVFVLlILLTSHYKLT-VPRFLMCNLAFADFCMGIYLLLI-ASVDLHTRseyynhaidWQTGP-GCNT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 183 WNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSgwytTTENYKYLKSNPH 262
Cdd:cd15964   83 AGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVG----VSSYAKVSICLPM 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 ICEFKVNKAYaIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhlqisqipkprpsIQVEQSTISTM 342
Cdd:cd15964  159 DTETPLAQAY-IVFVLMLNIIAFVIICACYIKIY-----------------------------------ITVRNPQYKSG 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCIT---PRLLVgILFWIgyFNSALNPIIYAYFNRDFR 412
Cdd:cd15964  203 DKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITvsnSKILL-VLFYP--LNSCANPFLYAIFTKAFR 272
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
113-415 3.74e-05

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 45.23  E-value: 3.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGK---------WMFGSvMCDMW 183
Cdd:cd15360    6 LIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGI-YLLLIASVDIRTKsqyynyaidWQTGA-GCAAA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 184 NSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIcsgwYTTTENYKYLKSNPHI 263
Cdd:cd15360   84 GFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPI----FGISSYMKVSICLPMD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 264 CEFKVNKAYaIVSSSMSFWIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhlqisqipkprpsIQVEQSTISTMR 343
Cdd:cd15360  160 IESPLSQAY-IIFILVLNVLAFLIICACYIKIY-----------------------------------LTVRNPNFVSSN 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 344 RERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15360  204 SDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
109-407 4.43e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 45.19  E-value: 4.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 109 VKCFIIGFIILAAILGNMLVIVSV--MRHRKLRIItnYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSF 186
Cdd:cd15387    2 VEVTVLALILFLALTGNICVLLAIhtTRHKHSRMY--FFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 187 DVYFSTASIMHLCCISVDRYYAIVQPLDYpliMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEF 266
Cdd:cd15387   80 QVVGMFASTYMLLLMSIDRCLAICQPLRS---LHRRSDRVYVLFSWLLSLVFSIPQVHIFSLREVGNGVYDCWADFIQPW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 267 KVnKAYAIVSSSMSFWIPGIVMLSMY----YRIYQEADRQERlvyrskvaallLEKHLQISQIPKPRPSIQVEQSTISTM 342
Cdd:cd15387  157 GP-KAYITWITLSVYIIPVLILSVCYglisFKIWQNVKLKTR-----------RETKTPLSSAASGGAALARVSSVKLIS 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYF 407
Cdd:cd15387  225 KAKIRTVKMTFVIVLAYIVCWTPFFFVQMWSVWDPNAPKEASPFIIAMLLASLNSCCNPWIYMFF 289
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
117-243 4.48e-05

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 45.14  E-value: 4.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVAlCAMTFNASVMISG-KWMFGSVMCdmwNSFDVYFST--- 192
Cdd:cd15368   10 VALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLA-CFLPFQIVYHIQRnHWIFGKPLC---NVVTVLFYAnmy 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPI 243
Cdd:cd15368   86 SSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLL-VLTALSPL 135
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
112-245 5.30e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 44.52  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFII--LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADmlvaLCAMTFNA-SVMISGKWMFGSV---MCDMWNS 185
Cdd:cd15431    3 LFVLLLIvyLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLD----ICYTTSSVpQMLVNCLSDRPTIsysRCLAQMY 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 186 FDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICS 245
Cdd:cd15431   79 ISLFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLT 138
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
112-244 5.89e-05

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 44.41  E-value: 5.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTfnasvmisgkwmfgSVMCDMW-NSFDVYF 190
Cdd:cd15222    5 IPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLP--------------TVLGIFWfNAREISF 70
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 191 S----------TASIMH---LCCISVDRYYAIVQPLDYPLIMTQRRVFIM--------LLMVWLSPALLSFLPIC 244
Cdd:cd15222   71 DaclaqmffihTFSFMEssvLLAMAFDRFVAICNPLRYASILTNSRIAKIglaivlrsVLLLLPLPFLLKRLPFC 145
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
112-245 6.69e-05

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 44.29  E-value: 6.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVA-------LCAMTFNAsvmisGKWMFGSVMCDMwn 184
Cdd:cd15952    5 FPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLStatipkmLGIFWFNL-----REISFGGCLAQM-- 77
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 185 sFDVYFSTA--SIMhLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSF--------LPICS 245
Cdd:cd15952   78 -FFIHTFTGmeSAV-LVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLpfvflilrLPFCG 146
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
112-244 7.15e-05

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 44.37  E-value: 7.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVAD----------MLVALCAMTFNASVMISGKWMFgsvmc 180
Cdd:cd15225    4 FVVFLLIyLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEicytsvivpkMLVNLLSEDKTISFLGCATQMF----- 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 181 dmwnsFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSF--------LPIC 244
Cdd:cd15225   79 -----FFLFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLgqttlifsLPFC 145
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
116-415 8.64e-05

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 44.07  E-value: 8.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15976    9 LVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLPICSGWYTTTENYKylKSNPHICEFKVNKAYAIV 275
Cdd:cd15976   89 LSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILA-VPEAIGFDMITMDYK--GELLRICLLHPIQKTAFM 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 276 ---SSSMSFWipgivMLSMYYRIyqeadrqerlvyrsKVAALLLEKHLQISQIPKPRPSIQVEQStiSTMRRERKAARTL 352
Cdd:cd15976  166 qfyKTAKDWW-----LFSFYFCL--------------PLACTAVFYTLMTCEMLRKKNGMQIALN--DHLKQRREVAKTV 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 353 GIIMSAFLICWLPFFLWYIVSSLC------DSCITPRLLVgILFWIGY----FNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15976  225 FCLVLVFALCWLPLHLSRILKLTIydekdpNRCELLSFFL-VLDYIGInmasLNSCINPIALYLVSKRFKNCF 296
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
104-244 9.07e-05

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 43.98  E-value: 9.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 104 LALVFVKCFIigfiilAAILGNMLVIVSVMRHRKLRIITNY-FVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCdM 182
Cdd:cd15935    3 LFVLVLACYA------AILLGNLLIVVTVHADPHLLQSPMYfFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGC-M 75
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281362294 183 WNSFDVYFSTASIMHLCCI-SVDRYYAIVQPLDYPLIMTQRRVFIMLLMVW--------LSPALLSFLPIC 244
Cdd:cd15935   76 AQLFFLHFLGGSEMLLLTLmAYDRYVAICHPLRYLAVMNRQLCIKLLAACWaggflhsaTQAALVLRLPFC 146
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
112-231 1.07e-04

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 43.74  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294  112 FIIGFIilaailGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLValcamtfNASVMISGKWMFGSVM-----CDMWNSF 186
Cdd:pfam10320   1 SVIGLF------GNVLMIHLTFRKKKLRSKCSILICVQCIAHLIC-------LCGEIVFVVLLFTGTQltrneCFWMISF 67
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 281362294  187 DVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMV 231
Cdd:pfam10320  68 YIFGQTAQGPLMLMIGIDRLIAVKFPIFYRLLSSSKYLFIQLIFP 112
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
113-239 1.10e-04

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 43.92  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVI-VSVMRHRKLRIITNYFVVSLAVADMLVALcAMTFNASVMISGK-WMFGSVMCDMwNSFdVYF 190
Cdd:cd15376    6 ILGVEFLVAVLGNGLALwLFVTRERRPWHTGVVFSFNLAVSDLLYAL-SLPLLAAYYYPPKnWRFGEAACKL-ERF-LFT 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 191 ST--ASIMHLCCISVDRYYAIVQPLdypliMTQRRV-----FIMLLMVWLSPALLS 239
Cdd:cd15376   83 CNlyGSIFFITCISLNRYLGIVHPF-----FTRSHVrpkhaKLVSLAVWLLVAALS 133
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
105-212 1.34e-04

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 43.27  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 105 ALVFVKC-FIIGFIIlaailgNMLVIVSVMRHRKLRIITNYFVVSLAVADmLVALCAMTFNASVMISGKWMFGSVMCDMW 183
Cdd:cd15166    3 ALVFYSFiFIIGLFV------NITALWVFSCTTKKRTTVTVYMMNVALVD-LIFILSLPFRMVYYAKDEWPFGDYFCRIL 75
                         90       100
                 ....*....|....*....|....*....
gi 281362294 184 NSFDVYFSTASIMHLCCISVDRYYAIVQP 212
Cdd:cd15166   76 GALTVFYPSIALWLLAFISADRYMAIVQP 104
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
116-241 1.36e-04

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 43.37  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVAD----------MLVALCamTFNASVMISGkwmfgsvmCDMWNS 185
Cdd:cd15918    9 GMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDicftsttvpkMLVNIQ--TQSKSISYAG--------CLTQMY 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 186 FDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFL 241
Cdd:cd15918   79 FFLLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLL 134
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
186-243 1.75e-04

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 43.07  E-value: 1.75e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 186 FDVYFS--TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPI 243
Cdd:cd15913   77 FYFFFSlgTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPV 136
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
106-239 2.27e-04

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 42.80  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 106 LVFVkcfIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNS 185
Cdd:cd15424    2 LLFV---VILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMY 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 281362294 186 FDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS 239
Cdd:cd15424   79 IALSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLS 132
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
108-241 2.41e-04

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 42.70  E-value: 2.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFD 187
Cdd:cd15420    1 LLLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLF 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFL 241
Cdd:cd15420   81 LALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALV 134
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
125-404 2.65e-04

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 42.44  E-value: 2.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 125 NMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVD 204
Cdd:cd16001   18 NGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFYTNLYGSILFLTCISVH 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 205 RYYAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGWYTTTENYK---YLKSNPHicEFKVNKAYAIVSSSMSF 281
Cdd:cd16001   98 RFLGVCYPIRSLAYRTRRLAVIGSAATWIL-VVLQLLPTLVYARTGSINNRtvcYDLTSPD--NFGNYFPYGMVLTVTGF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 282 WIPGIVMLSMYYRIYQEADRQErlvyrskvaalllekhlqisqipkprpsiqvEQSTISTMRReRKAARTLGIIMSAFLI 361
Cdd:cd16001  175 LIPFLIILLCYCLMIKSLIRSE-------------------------------EAAGVGKAAR-AKSIRTILLVCGLFAL 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 281362294 362 CWLPF--------FLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIY 404
Cdd:cd16001  223 CFVPFhitrtiylFVRVYLVQDCPLLQFVSLAYKIWRPLVSFNSCINPLLY 273
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
106-244 2.81e-04

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 42.42  E-value: 2.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 106 LVFVKCFIIGFIILaaiLGNMLVIVSVMRHRKLRIITNYFVVSLAVAD----------MLVALcaMTFNASVMISGkwmf 175
Cdd:cd15945   15 TLFLVFLLVYLLTL---VGNVGMIILIRMDSQLHTPMYYFLSNLSFLDlcystaigpkMLVDL--LAKRKSIPFYG---- 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 176 gsvmCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIC 244
Cdd:cd15945   86 ----CALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTT 150
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
108-413 3.02e-04

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 42.50  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 108 FVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFD 187
Cdd:cd15076    1 YLQAAFMGFVFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDyPLIMTQRRVFIMLLMVWLSPALLSFLPI------------CS---GWYTTTE 252
Cdd:cd15076   81 SLAGLVTGWSLAFLAFERYIVICKPFG-NFRFGSKHALGAVVATWIIGIGVSLPPFfgwsryipeglqCScgpDWYTVGT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 253 NYKylksnphicefkvNKAYAIVSSSMSFWIPGIVMLSMYYRIyqeadrqerLVYRSKVAALllekhlqisqipkprpsi 332
Cdd:cd15076  160 KYR-------------SEYYTWFLFIFCFIVPLSIIIFSYSQL---------LGALRAVAAQ------------------ 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 333 qvEQSTISTMRRERKAARTLGIIMSAFLICWLPF--FLWYIVSSLcDSCITPRLlVGILFWIGYFNSALNPIIYAYFNRD 410
Cdd:cd15076  200 --QQESASTQKAEREVSRMVVVMVGSFCLCYVPYaaLAMYMVNNR-DHGLDLRL-VTIPAFFSKSSCVYNPIIYCFMNKQ 275

                 ...
gi 281362294 411 FRA 413
Cdd:cd15076  276 FRA 278
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
111-241 3.25e-04

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 42.26  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYF 190
Cdd:cd15237    4 FILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLAL 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 281362294 191 STASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFL 241
Cdd:cd15237   84 GVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLV 134
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
145-234 3.45e-04

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 42.43  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 145 FVVSLAVADMLVaLCAMTF-NASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRR 223
Cdd:cd15147   40 FMVNLTIADLLF-LITLPFwIVYYHNEGNWILPKFLCNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKR 118
                         90
                 ....*....|.
gi 281362294 224 VFIMLLMVWLS 234
Cdd:cd15147  119 GIIISVAIWVI 129
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
113-243 3.63e-04

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 42.11  E-value: 3.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNY--FVVSLAVADMLVALCAMTFNASVMISG-KWMFGSVMCDMWNSFD-- 187
Cdd:cd15143    9 IFSAIGLASNLFAFIVLVKSSRKTKSRSRSSFliFLCGLVVTDFLGLLVTGTIVISFHLTNfNWRVVDPDCYLCNFMGls 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 188 -VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPI 243
Cdd:cd15143   89 mVFYGLCPLLLGATMAVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFLLGLLPI 145
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
116-241 4.08e-04

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 41.91  E-value: 4.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15915    9 LLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEA 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFL 241
Cdd:cd15915   89 MLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALM 134
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
111-244 4.46e-04

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 41.81  E-value: 4.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMlvalCAMTFNASVMISGKWM------FGSVMCDMW 183
Cdd:cd15226    3 LFVFFSLFyVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDL----CLSSFATPKMICDLLRehktisFGGCMAQIF 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 184 nsFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL-----SPALLSF---LPIC 244
Cdd:cd15226   79 --FLHFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIigfihSLSQLAFvvnLPFC 145
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
120-243 5.17e-04

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 41.73  E-value: 5.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 120 AAILGNMLVIVSVMRHRK-LRIITNYF---VVSLAVADML-------VALCAMTFNASVMISGKwmfGSVMCDMWNSFDV 188
Cdd:cd15141   13 AGVVGNLLALGILGVHRKeRRTKSSAFcvlVTGLAATDLLgtcflspMVFVSYAQNSSLLGLAA---GQPLCHLFAFAMT 89
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPI 243
Cdd:cd15141   90 FFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFGALFCALPL 144
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
112-241 5.40e-04

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 41.67  E-value: 5.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVA-------LCAMTFNASVMISgkwmFGSVMCDMW 183
Cdd:cd15916    4 FLIFLIIyLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLStvtvpkmLAGFLEPGGKVIS----FGGCVAQLY 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 281362294 184 nSFDVYFSTASIMHlCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFL 241
Cdd:cd15916   80 -FFHFLGSTECFLY-TLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAI 135
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
122-415 6.13e-04

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 41.29  E-value: 6.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 122 ILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNAsVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCI 201
Cdd:cd15923   15 LLLNILALWVFCWRLKKWTETNIYMTNLAVADLLL-LISLPFKM-HSYRRESAGLQKLCNFVLSLYYINMYVSIFTITAI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 202 SVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGwyTTTENYKYLKSNPHICEFKVNKAYAIVsssmSF 281
Cdd:cd15923   93 SVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLD--SSNEKTMCFQRTKQTESLKVFLLLEIF----GF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 282 WIPGIVMLSMYYRIyqeadrqerlvyrskvaalllekhlqISQIPKPRPSIQVEQSTistmrreRKAARTLGIIMSAFLI 361
Cdd:cd15923  167 LLPLIIMTFCSARV--------------------------IHTLQKRLDDVGSRSET-------KQCIRVIMANLIVFIV 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 362 CWLP----FFLWYIV--SSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15923  214 CFLPvhvgFFVKFIVgkSYSCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFREAY 273
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
130-232 7.57e-04

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 41.32  E-value: 7.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 130 VSVMRHRKLRIitnyFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMwnsFDVYFST---ASIMHLCCISVDRY 206
Cdd:cd15366   27 LQVRQRNELGV----YLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKL---FGFIFYTniyISIAFLCCISVDRY 99
                         90       100
                 ....*....|....*....|....*.
gi 281362294 207 YAIVQPLDYPLIMTQRRVFIMLLMVW 232
Cdd:cd15366  100 LAVAHPLRFAKVRRVKTAVAVSAVVW 125
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
117-239 8.90e-04

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 40.88  E-value: 8.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15942   10 VYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECF 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLS 239
Cdd:cd15942   90 LYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHS 132
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
116-245 9.18e-04

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 40.86  E-value: 9.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASI 195
Cdd:cd15950    9 SMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVES 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 196 MHLCCISVDRYYAIVQPLDYPLIMTQRRVFIM---------LLMVWLSpALLSFLPICS 245
Cdd:cd15950   89 GVLLAMAFDRYVAICHPLRYSAILTSQVIAQIglaivlralLFMTPLT-CLVTSLPYCG 146
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
116-232 1.18e-03

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 40.63  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADmlvaLCAMTFNASVMI----SGKWMFGSVMCdMWNSFDVYFS 191
Cdd:cd15938    9 LAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLD----LCYSTVTCPKMLvdflSQRKAISYEAC-IAQLFFLHFV 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 281362294 192 TASIMHLCCI-SVDRYYAIVQPLDYPLIMTQRRVFIMLLMVW 232
Cdd:cd15938   84 GAAEMFLLTVmAYDRYVAICKPLHYTTIMSRRLCWVLVAASW 125
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
117-411 1.27e-03

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 40.54  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLViVSVMRHRKLRIITNYFVVSLAVADMLVALcamTFNASVMIS---GKWMFGSVMCdMWNSFDVYFST- 192
Cdd:cd15969   10 IFIGSILLNGLA-VWIFFHIRNKTSFIFYLKNIVIADLLMTL---TFPFKIIQDsglGPWNFNFFLC-RYTSVLFYASMy 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSfLP--ICSGWYTTTENY---KYLKSNphiceFK 267
Cdd:cd15969   85 TSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLS-LPniILTNGQPTEDNIhdcSKLKSP-----LG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSSSMSFWIPGIVMLSMYYriyqeadrqerlvyrskvaaLLLEKHLQISQipkprpsiqveQSTISTMRRERK 347
Cdd:cd15969  159 VKWHTAVSYINICIFVAVLVILIVCY--------------------ISISRYIYKSS-----------KQFISSSSRTRK 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362294 348 AARTLGIIMSAFLICWLPFFLWYI------VSSLCDSCITPRLLVG--ILFWIGYFNSALNPIIYAYFNRDF 411
Cdd:cd15969  208 HNQSIRVVVAVFFVCFLPYHLCRIpftfsqLDKILDCTIKTILYYCkeATLFLSACNVCLDPIIYFFMCRSF 279
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
145-233 1.27e-03

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 40.52  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 145 FVVSLAVADMLVaLCAMTFNASVMISG-KWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRR 223
Cdd:cd15367   38 YLCNLTVADLLY-IFSLPFWLQYVLQHdNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKA 116
                         90
                 ....*....|
gi 281362294 224 VFIMLLMVWL 233
Cdd:cd15367  117 ATLVSTVIWL 126
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
112-244 1.41e-03

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 40.34  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFV----------VSLAVADMLVALCAMTFNASVM--ISGKWMFGSV 178
Cdd:cd15224    4 FLLFLIAyVLTLLENLLIILTIWLNSQLHKPMYFFLsnlsfleiwyISVTVPKLLAGFLSQNKSISFVgcMTQLYFFLSL 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 179 MCdmwnsfdvyfsTASIMhLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIC 244
Cdd:cd15224   84 AC-----------TECVL-LAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVY 137
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
106-234 1.58e-03

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 40.15  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 106 LVFVkCFIIGFIIlaAILGNMLVIVSVMRHRKLRIITNYFVVSLAVAD----------MLVALCAMTFNASVM--ISGKW 173
Cdd:cd15432    2 VLFV-VFLIFYIL--TLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDlcyttstvpqMLVNLRSPQKTISYGgcVAQLF 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 174 MF---GSVMCDMwnsfdvyfstasimhLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLS 234
Cdd:cd15432   79 IFlglGSTECVL---------------LAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWIS 127
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
113-415 1.66e-03

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 40.23  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFnASVMISGK---------WMFGSvMCDMW 183
Cdd:cd15359    6 LIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLI-ASVDSQTKsqyynhaidWQTGS-GCSTA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 184 NSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSgwyttTENY-KYLKSNPH 262
Cdd:cd15359   84 GFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVG-----VSNYmKVSICLPM 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 263 ICEFKVNKAYAIVSSSMSFwIPGIVMLSMYYRIYqeadrqerlvyrskvaalllekhlqisqipkprpsIQVEQSTISTM 342
Cdd:cd15359  159 DIETLLSQAYILLILVLNV-IAFLVICACYIKIY-----------------------------------LAVQNPELVAK 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281362294 343 RRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
Cdd:cd15359  203 NKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
115-243 1.76e-03

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 39.85  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 115 GFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd15956    8 CFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAME 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 281362294 195 IMHLCCISVDRYYAIVQPLDYPLIMTQRRV-FIMLLMVWLSPALLSFLPI 243
Cdd:cd15956   88 SGVLVAMALDRFVAICNPLHYATILTLEVVaKAGLLLALRGVAIVIPFPL 137
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
117-222 2.04e-03

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 39.70  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADmlvALCAMTFNASVMI---SGKWMFGSVMCDMWNSFDVYFSTA 193
Cdd:cd15409   10 IYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFAD---ACTSSSVTPKMLVnflSKNKMISFSGCAAQFFFFGFSATT 86
                         90       100
                 ....*....|....*....|....*....
gi 281362294 194 SIMHLCCISVDRYYAIVQPLDYPLIMTQR 222
Cdd:cd15409   87 ECFLLAAMAYDRYVAICNPLLYPVVMSNR 115
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
116-246 2.41e-03

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 39.55  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLV-------ALCAMTFNASVmISgkwmFGSVMCDMWnsfdv 188
Cdd:cd15953    9 LMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLstsvvpkALCIFWFNLKE-IT----FSGCLTQMF----- 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281362294 189 YFSTASIMH---LCCISVDRYYAIVQPLDYPLIMTQRRVFIM--------LLMVWLSPALLSFLPICSG 246
Cdd:cd15953   79 FIHTLSIMEsavLVAMAFDRYVAICNPLRYATILTNSRIAKLglvglirgVLLILPLPLLLSRLPFCAN 147
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
107-233 2.43e-03

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 39.63  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 107 VFVKCFIIGFIIlaailgNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNasvMISGK--WMFGSVMCDMWN 184
Cdd:cd15165    6 VYIPTFVLGLLL------NLMALWVFLFKIKKWTESTIYMINLALNDLLL-LLSLPFK---MHSSKkqWPLGRTLCSFLE 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 281362294 185 SfdVYFST--ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL 233
Cdd:cd15165   76 S--LYFVNmyGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWV 124
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
118-412 2.68e-03

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 39.35  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 118 ILAAILGNMLVIVSVMRHRKLRIITNYfVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNsFDVYFST-ASIM 196
Cdd:cd15373   12 VVGLVLNILALYVFLFRTKPWNASTTY-MFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVR-FLFYTNLyCSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL------SPALlsflpicsgWYTTTENykylKSNPHICE----- 265
Cdd:cd15373   90 FLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVivlacqSPVL---------YFVTTSD----KGGNITCHdtssp 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 266 --FKVNKAYAIVSSSMSFWIPGIVMLSMYYriyqeadrqerlvyrskvaalllekhLQISQIPKPRpsiqveQSTISTMR 343
Cdd:cd15373  157 elFDQFVVYSSVMLVLLFCVPFVVILVCYA--------------------------LMVRKLLKPS------AGTSTNSR 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 344 RERKAARTLGIIMSAFLICWLPFF----LWYIVSSLCDSCITPRlLVGILFWI----GYFNSALNPIIYAYFNRDFR 412
Cdd:cd15373  205 SKKKSVKMIIIVLAVFILCFLPFHvtrtLYYSFRSMDLSCGTLN-AINLAYKVtrplASANSCLDPILYFLAGQSFR 280
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
111-244 2.81e-03

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 39.46  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 111 CFIIGFIILAAILGNMLVIVSVmrHRKLRIITN-YFVVS-LAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15421    4 FSLILLIFLVALTGNALLILLI--WLDSRLHTPmYFLLSqLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSF--------LPIC 244
Cdd:cd15421   82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLihtvytmhFPYC 145
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
119-224 3.66e-03

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 38.81  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 119 LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLvaLCAMTFNASVMI----SGKWMFGSVMCDMWNSFDVYFSTAS 194
Cdd:cd15221   12 IVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLL--LSTTTVPKMLAIfwfgAGEISFDGCLTQMFFVHFVFVTESA 89
                         90       100       110
                 ....*....|....*....|....*....|
gi 281362294 195 ImhLCCISVDRYYAIVQPLDYPLIMTQRRV 224
Cdd:cd15221   90 I--LLAMAFDRYVAICYPLRYTTILTHSVI 117
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
113-239 4.08e-03

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 39.08  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILA-AILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLV---ALCAMTFNAsvmISGKWMFGSVMCDMWNSFDV 188
Cdd:cd15126    5 LLALVVFAvGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVlffCLPVVVFNE---ITKKRLLGDVSCRVVPYMEV 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 281362294 189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQ-RRVFIMLLMVWLSPALLS 239
Cdd:cd15126   82 TSLGVTTFSLCALGIDRFHAATSPQPKARPVERcQSILAKLAVIWVGSMTLA 133
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
117-242 4.33e-03

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 39.07  E-value: 4.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196
Cdd:cd15127   10 IFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGVTTF 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 281362294 197 HLCCISVDRYYAIVQ-PLDYPLIMTQRRVFIMLLMVWLSpALLSFLP 242
Cdd:cd15127   90 TLCALCIDRFRAATNvQMYYEMIENCTSTTAKLAVIWVG-ALLLALP 135
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
127-414 4.36e-03

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 38.63  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 127 LVIVSVMRHRKLRIITnyFVVSLAVADMLVALCaMTFNASVMIsgkWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRY 206
Cdd:cd15920   22 LWVFFLRQQRETSISV--YMRNLALADLLLVLC-LPFRVAYQN---TAGPLSFCKIVGAFFYLNMYASILFLSLISLDRY 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 207 YAIVQPLDYPLIMTQRRVFIMLLMVWLSpALLSFLPICSGwytttenykylKSNPHICEfkvNKAYAIVSSSMSFWIPGI 286
Cdd:cd15920   96 LKIIKPLQQFKIHTVPWSSAASGGVWLL-LLACMIPFLFE-----------SRNEGPCD---NKCFHFRSKGLTAGGINL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 287 VMLSMYYRIYQEAdrqerLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTIstmrrerkaartlgIIMSAFLICWLPF 366
Cdd:cd15920  161 TAVVIFYILSLLF-----LYFYAKISHKLYKVSLGNAQQQIKKASKRAIIKTF--------------IVLAIFIVCFVPY 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 367 FLW---YIVSSL-----CDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414
Cdd:cd15920  222 HIVrvpYVLAQIdvissLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRRA 277
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
112-244 4.36e-03

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 38.78  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADML---VALCAMTFNasvMISGKWMFGSVMCDMWNSFD 187
Cdd:cd15231    4 FLIFLIIyLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICytsVTVPKMLVN---LLRERKTISYIGCLAQLFFF 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281362294 188 VYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLS--------PALLSFLPIC 244
Cdd:cd15231   81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCgflnsavhTVLTFRLSFC 145
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
113-411 5.14e-03

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 38.60  E-value: 5.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVaLCAMTFNASVMISG-KWMFGSVMCDMwNSFDVYFS 191
Cdd:cd15200    6 VLGIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFL-IINLPFRIDYYLRNeVWRFGATACQV-NLFMLSMN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 192 -TASIMHLCCISVDRYYAIVQP---LDYPLIMTQRRVFIMLlmvWLSPALLSflpicSGWYTTTENYkylkSNPHICEFK 267
Cdd:cd15200   84 rTASIVFLTAIALNRYLKVVHPhhqLSKASVGCAAKVAAGL---WILILLLN-----IHLLLLDHVQ----SNSTCLSYD 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 268 VNKAYAIVSS------SMSFWIP-GIVMLSMYYRIyqeadrqerlvyrskvaalllekhlqisqipkprpsIQVEQSTIS 340
Cdd:cd15200  152 HGTDPSASDRwhrilfFLEFFLPlGIILFCIFSII------------------------------------LTLKQRKLA 195
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362294 341 TMRRERKAARTLGIIMSAFLICWLPFFLWYIVS------SLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDF 411
Cdd:cd15200  196 KQAGPQRAVKVLAVIVLVYTVCFLPSILFALASlvafkvSQCRSLDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSF 272
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
117-244 6.14e-03

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 38.21  E-value: 6.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMlvALCAMTFNASVMI----SGKWMFGSVMCDMWnsFDVYFST 192
Cdd:cd15955   10 MFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDL--GLCPCILPKMLAIfwfqLREISFNACLAQMF--FIHTLQA 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 281362294 193 ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIC 244
Cdd:cd15955   86 FESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPL 137
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
198-234 6.72e-03

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 37.99  E-value: 6.72e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 281362294 198 LCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLS 234
Cdd:cd15947   91 LAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLS 127
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
104-404 7.76e-03

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 37.84  E-value: 7.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 104 LALVFVKCFIIGFIilAAILGNMLVIVSVMRHRKLRIitnyFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMw 183
Cdd:cd15364    3 LVVVYSVVFALGFP--ANCLTLWLTLLQVRRKNVLAV----YLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKI- 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 184 nSFDVYFST--ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALL---SFLPICSGWYTTTENYKYLK 258
Cdd:cd15364   76 -TGYIFFCNiyISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVhspVFIMREGQTEGSHTCFETLQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 259 SNPHICEFkvNKAYAIVsssmSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAAllleKHLQISqipkprpsiqveqst 338
Cdd:cd15364  155 MDTQVAGF--YYARFCI----GFAIPLAILIFTNYRIFRSIQTSTSLTPHQKAKV----KYLAIA--------------- 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362294 339 istmrrerkaartlgiIMSAFLICWLPFFLWYIVSSLCDScITPRLLVG----------ILFWIGYFNSALNPIIY 404
Cdd:cd15364  210 ----------------VIVIFLICFAPYHLVLLVRAIAFS-LYPNGMCGfeeriytpsvIFLCLSTVNSVADPIIY 268
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
145-233 7.90e-03

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 37.85  E-value: 7.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 145 FVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRV 224
Cdd:cd15370   38 YMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMSHSRKKANIAI 117
                         90
                 ....*....|..
gi 281362294 225 FIML---LMVWL 233
Cdd:cd15370  118 GISLaiwLLILL 129
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
116-226 7.99e-03

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 38.17  E-value: 7.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 116 FIILAAILGNML---VIVSVMRHRKLRIItnyFVVSLAVADMLVALcAMTFNASVMISGKWMFGSVMCdMWNSFDVYFST 192
Cdd:cd15152    9 VILIPGLIGNVLalwVFYAYVKETKRAVI---FMINLAIADLLQVL-SLPLRIFYYLNKSWPFGKFLC-MFCFYLKYVNM 83
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 281362294 193 -ASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFI 226
Cdd:cd15152   84 yASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYI 118
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
112-244 8.02e-03

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 37.85  E-value: 8.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362294 112 FIIGFII-LAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVAD----------MLVALcaMTFNASVMISGkwmfgsvmC 180
Cdd:cd15911    4 FLLFLVIyIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEicytstilprMLASL--LTGDRTISVSG--------C 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281362294 181 DMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPIC 244
Cdd:cd15911   74 IVQFYFFGSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVI 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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