Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) ...
95-641
0e+00
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) proteins 1 and 2, which includes the transmembrane and cytosolic regions. These are vertebrate-specific proteins involved in neuronal migration during neurodevelopment. ASTN1 is a neuronal receptor required for neuroblasts migration along glial fibers, especially in the cerebellum. ASTN2 is an endosome membrane protein that binds ASTN1 and mediates its recycling by promoting ASTN1 internalization and transport during its endocytosis.
The actual alignment was detected with superfamily member pfam19441:
Pssm-ID: 437273 Cd Length: 555 Bit Score: 1141.33 E-value: 0e+00
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane ...
917-1134
1.91e-66
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane proteins with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN-2. They play critical roles in neurodevelopment, and ASTN-2 is also involved in the planar cell polarity pathway in hair cells. This is a domain found in the middle of the C-terminal of ASTN-1 and 2, which comprises a EGF- like domain (EGF4) and a fibronectin type III (Fn(III)) domain. These subdomains are located between the MACPF and annexin- like domains. The structure of Fn(III) from ASTN2 revealed an unexpected feature which has two additional beta strands folded across the core. The junction between EGF-4 and Fn(III) domains in ASTN2 (but not in ASTN1) is thought to be an inositol triphosphate binding site.
The actual alignment was detected with superfamily member pfam19743:
Pssm-ID: 437575 Cd Length: 216 Bit Score: 223.65 E-value: 1.91e-66
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an ...
1145-1237
8.91e-55
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an integral membrane perforin-like protein linked to the planar cell polarity pathway in hair cells. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, yet shares no sequence homology with it. Notably, this ASTN-2 annexin-like domain is closer in structure to human annexin repeat 3 than human annexin repeat 3 is to repeat 1. Annexin-like domains are known for their capacity to remodel membranes, triggered by calcium binding, and have also been suggested to be involved in the formation of pores in membranes both are possible biological roles of the ASTN-2 annexin-like domain.
:
Pssm-ID: 465756 Cd Length: 93 Bit Score: 185.07 E-value: 8.91e-55
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
652-699
4.40e-05
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
:
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 41.84 E-value: 4.40e-05
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) ...
95-641
0e+00
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) proteins 1 and 2, which includes the transmembrane and cytosolic regions. These are vertebrate-specific proteins involved in neuronal migration during neurodevelopment. ASTN1 is a neuronal receptor required for neuroblasts migration along glial fibers, especially in the cerebellum. ASTN2 is an endosome membrane protein that binds ASTN1 and mediates its recycling by promoting ASTN1 internalization and transport during its endocytosis.
Pssm-ID: 437273 Cd Length: 555 Bit Score: 1141.33 E-value: 0e+00
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane ...
917-1134
1.91e-66
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane proteins with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN-2. They play critical roles in neurodevelopment, and ASTN-2 is also involved in the planar cell polarity pathway in hair cells. This is a domain found in the middle of the C-terminal of ASTN-1 and 2, which comprises a EGF- like domain (EGF4) and a fibronectin type III (Fn(III)) domain. These subdomains are located between the MACPF and annexin- like domains. The structure of Fn(III) from ASTN2 revealed an unexpected feature which has two additional beta strands folded across the core. The junction between EGF-4 and Fn(III) domains in ASTN2 (but not in ASTN1) is thought to be an inositol triphosphate binding site.
Pssm-ID: 437575 Cd Length: 216 Bit Score: 223.65 E-value: 1.91e-66
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an ...
1145-1237
8.91e-55
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an integral membrane perforin-like protein linked to the planar cell polarity pathway in hair cells. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, yet shares no sequence homology with it. Notably, this ASTN-2 annexin-like domain is closer in structure to human annexin repeat 3 than human annexin repeat 3 is to repeat 1. Annexin-like domains are known for their capacity to remodel membranes, triggered by calcium binding, and have also been suggested to be involved in the formation of pores in membranes both are possible biological roles of the ASTN-2 annexin-like domain.
Pssm-ID: 465756 Cd Length: 93 Bit Score: 185.07 E-value: 8.91e-55
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
652-699
4.40e-05
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 41.84 E-value: 4.40e-05
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) ...
95-641
0e+00
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) proteins 1 and 2, which includes the transmembrane and cytosolic regions. These are vertebrate-specific proteins involved in neuronal migration during neurodevelopment. ASTN1 is a neuronal receptor required for neuroblasts migration along glial fibers, especially in the cerebellum. ASTN2 is an endosome membrane protein that binds ASTN1 and mediates its recycling by promoting ASTN1 internalization and transport during its endocytosis.
Pssm-ID: 437273 Cd Length: 555 Bit Score: 1141.33 E-value: 0e+00
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane ...
917-1134
1.91e-66
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane proteins with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN-2. They play critical roles in neurodevelopment, and ASTN-2 is also involved in the planar cell polarity pathway in hair cells. This is a domain found in the middle of the C-terminal of ASTN-1 and 2, which comprises a EGF- like domain (EGF4) and a fibronectin type III (Fn(III)) domain. These subdomains are located between the MACPF and annexin- like domains. The structure of Fn(III) from ASTN2 revealed an unexpected feature which has two additional beta strands folded across the core. The junction between EGF-4 and Fn(III) domains in ASTN2 (but not in ASTN1) is thought to be an inositol triphosphate binding site.
Pssm-ID: 437575 Cd Length: 216 Bit Score: 223.65 E-value: 1.91e-66
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an ...
1145-1237
8.91e-55
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an integral membrane perforin-like protein linked to the planar cell polarity pathway in hair cells. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, yet shares no sequence homology with it. Notably, this ASTN-2 annexin-like domain is closer in structure to human annexin repeat 3 than human annexin repeat 3 is to repeat 1. Annexin-like domains are known for their capacity to remodel membranes, triggered by calcium binding, and have also been suggested to be involved in the formation of pores in membranes both are possible biological roles of the ASTN-2 annexin-like domain.
Pssm-ID: 465756 Cd Length: 93 Bit Score: 185.07 E-value: 8.91e-55
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
652-699
4.40e-05
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 41.84 E-value: 4.40e-05
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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