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Conserved domains on  [gi|285026506|ref|NP_001165555|]
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alpha-L-iduronidase precursor [Rattus norvegicus]

Protein Classification

6-phospho-beta-glucosidase; DMT family transporter( domain architecture ID 10472212)

6-phospho-beta-glucosidase catalyzes the conversion of 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate| DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Glyco_hydro_39 pfam01229
Glycosyl hydrolases family 39;
29-524 0e+00

Glycosyl hydrolases family 39;


:

Pssm-ID: 426141  Cd Length: 472  Bit Score: 704.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506   29 YLVRVDAARPLRPLLPFWRST-GFCPPLPHDQADqydlsWDQQLNLAYigavPHSGIEQVRIH-WLLDLITA-RKSSGQG 105
Cdd:pfam01229   1 VKIKVDAARDLRKLTPFWRSCvGFCPPLPALQAD-----WDQQLNLAY----PHIGFEYVRGHgWLLDDITAyRESVDQG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  106 LIYNFTHLDAFLDLLMENQLLPGFEL--------MGSPSGYF--TDFEDKQQVFEWKDLVSLLARRYIGKYGLTNVSKWN 175
Cdd:pfam01229  72 LFYNFTHIDRILDLLLENGLLPFFELgfmpkrlaSGTPTVFFweGNFTPPKQYEEWKNLVSLLARHYIGRYGLDEVSKWN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  176 FETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLRLGGPGDSFHPLPRspmcwSLLGHCANGTnfftgevgVRL 255
Cdd:pfam01229 152 FETWNEPNLKDFDWVDMTEQEYFNLYKACAEAIKEVSPNLKVGGPADSFDPWIR-----SLLEFCYNGN--------VPL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  256 DYISLH---KKGAGSSIAILEQEVAV------VEQIQQLFPKFKDTPIYNDEADPlvGWSLPQPWRADVTYAALVVKVIA 326
Cdd:pfam01229 219 DFISLHaysKKGAGSSILILEEEMASeymlneVKQVRELIPEFPDLPVYNTEANP--SWSPPQPWHDDPTYAAYVVKVIA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  327 QHQNLLFANSSSSMRYILLSNDNAFLSYHpypfsqrtltARFQVNNTHPphvqlLRKPVLTVMGLMALLDGEQLWAEvlk 406
Cdd:pfam01229 297 QHQDLPDANSYWTFRDVFEENDNAFLSFH----------GGFGLNNTHP-----IPKPVLTAFKLLALLDGEQLWAE--- 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  407 agaVLDSNHTVGVLASTHHPEGPSEAWRTTVLIYTSDDTHIHPNDSIPVILHLRGvPPGLELVYVVLYLDNQLSSPYSAW 486
Cdd:pfam01229 359 ---VSDSNHTVGVIASRHDPSGALIAWNEIVLIYSSDDTTAHPDKEYPVTLRLNG-PVGFKLVYIKLMIDEDHGNPWGTW 434

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 285026506  487 QHMGQPVFPSAEQFRQMRMVEDPVAEAPRPFPARGRLT 524
Cdd:pfam01229 435 QHMGRPVFPSKEQIRRLRDAEKPKAEAPRPFPADGRLT 472
 
Name Accession Description Interval E-value
Glyco_hydro_39 pfam01229
Glycosyl hydrolases family 39;
29-524 0e+00

Glycosyl hydrolases family 39;


Pssm-ID: 426141  Cd Length: 472  Bit Score: 704.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506   29 YLVRVDAARPLRPLLPFWRST-GFCPPLPHDQADqydlsWDQQLNLAYigavPHSGIEQVRIH-WLLDLITA-RKSSGQG 105
Cdd:pfam01229   1 VKIKVDAARDLRKLTPFWRSCvGFCPPLPALQAD-----WDQQLNLAY----PHIGFEYVRGHgWLLDDITAyRESVDQG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  106 LIYNFTHLDAFLDLLMENQLLPGFEL--------MGSPSGYF--TDFEDKQQVFEWKDLVSLLARRYIGKYGLTNVSKWN 175
Cdd:pfam01229  72 LFYNFTHIDRILDLLLENGLLPFFELgfmpkrlaSGTPTVFFweGNFTPPKQYEEWKNLVSLLARHYIGRYGLDEVSKWN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  176 FETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLRLGGPGDSFHPLPRspmcwSLLGHCANGTnfftgevgVRL 255
Cdd:pfam01229 152 FETWNEPNLKDFDWVDMTEQEYFNLYKACAEAIKEVSPNLKVGGPADSFDPWIR-----SLLEFCYNGN--------VPL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  256 DYISLH---KKGAGSSIAILEQEVAV------VEQIQQLFPKFKDTPIYNDEADPlvGWSLPQPWRADVTYAALVVKVIA 326
Cdd:pfam01229 219 DFISLHaysKKGAGSSILILEEEMASeymlneVKQVRELIPEFPDLPVYNTEANP--SWSPPQPWHDDPTYAAYVVKVIA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  327 QHQNLLFANSSSSMRYILLSNDNAFLSYHpypfsqrtltARFQVNNTHPphvqlLRKPVLTVMGLMALLDGEQLWAEvlk 406
Cdd:pfam01229 297 QHQDLPDANSYWTFRDVFEENDNAFLSFH----------GGFGLNNTHP-----IPKPVLTAFKLLALLDGEQLWAE--- 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  407 agaVLDSNHTVGVLASTHHPEGPSEAWRTTVLIYTSDDTHIHPNDSIPVILHLRGvPPGLELVYVVLYLDNQLSSPYSAW 486
Cdd:pfam01229 359 ---VSDSNHTVGVIASRHDPSGALIAWNEIVLIYSSDDTTAHPDKEYPVTLRLNG-PVGFKLVYIKLMIDEDHGNPWGTW 434

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 285026506  487 QHMGQPVFPSAEQFRQMRMVEDPVAEAPRPFPARGRLT 524
Cdd:pfam01229 435 QHMGRPVFPSKEQIRRLRDAEKPKAEAPRPFPADGRLT 472
XynB COG3664
Beta-xylosidase [Carbohydrate transport and metabolism];
16-539 3.60e-37

Beta-xylosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442881  Cd Length: 490  Bit Score: 145.06  E-value: 3.60e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  16 AFLASPLALAETPYLVRVDAARPLRPLLPFWRSTGfcpplphDQADQY----DLSWDQQLNLAYIGAVPHsgieqVRIHW 91
Cdd:COG3664    4 TLLGPLAAAAPPPVAITVDLAKVAGPMKPLWAWFG-------YDEPNYtymkDGKKLLSEGAGLSPVFRY-----IRFHG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  92 LL--DLITARKSSGQGLIYNFTHLDAFLDLLMENQLLP----GF---ELMGSPSGYF---------TDFEdkqqvfEWKD 153
Cdd:COG3664   72 LFhdDMGVYREDADGNPVYNFTYVDKIFDFLLELGMKPfvelGFmpeALASGPQTVFwwkgnvtppKDYA------KWAD 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506 154 LVSLLARRYIGKYGLTNVSKWNFETWNEPDHHDFdnVSMTTQGFLNYYDACSEGLRIASPTLRLGGPGDSfhplPRSPMc 233
Cdd:COG3664  146 LVRAFVRHLIDRYGIDEVRSWYFEVWNEPNLSGF--WKGTQEEYFKLYDYTARAVKSVDPRLRVGGPATA----GGAAA- 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506 234 W--SLLGHCAngtnfftgEVGVRLDYISLHKKGAGSSI---------AILEQEVAVVEQIQQlfPKFKDTPIYNDEADpl 302
Cdd:COG3664  219 WlpDFLEHCA--------KNGVPVDFVSTHAYGTDPGFdgqlsmnpdAVLRDVEKVRKLIAA--SAFPNLPLHITEWN-- 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506 303 VGWSLPQPWRADVTYAALVVKVIAQHQNLlfANSsssmryillsndnaflsyhpypFSQRTLTARF--QVNNTHPPH--- 377
Cdd:COG3664  287 TSYTPRDPYHDTAFYAAYIAKSLKRAGDL--ADS----------------------MSYWTFSDIFeeAGPPTQPFHggf 342

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506 378 ----VQLLRKPVLTVMGLMALLDGEQLwaevlkagAVLDSNhtvgVLASThHPEGpseawRTTVLIYTSDDTHIHPNDSi 453
Cdd:COG3664  343 gllnTNGIKKPVYHAFRMLNRLGGERL--------AVGDDD----AVATR-DDDG-----RVAVLVWNYHDDDPAGPAR- 403

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506 454 PVILHLRGVPPGleLVYVVLY-LDNQLSSPYSAWQHMGQPVFPSAEQFRQMRMVEDPVAEAPRPFPARGRLTLYRKLPVP 532
Cdd:COG3664  404 TVELTLTGLPAG--KYRLTVYrVDEEHGNAYAAWLEMGSPQQPTREQIAELKAAAELQTSPEVVVVADGKLTLDLTLPRN 481


                 ....*..
gi 285026506 533 SLMLVHL 539
Cdd:COG3664  482 SVVLIEL 488
 
Name Accession Description Interval E-value
Glyco_hydro_39 pfam01229
Glycosyl hydrolases family 39;
29-524 0e+00

Glycosyl hydrolases family 39;


Pssm-ID: 426141  Cd Length: 472  Bit Score: 704.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506   29 YLVRVDAARPLRPLLPFWRST-GFCPPLPHDQADqydlsWDQQLNLAYigavPHSGIEQVRIH-WLLDLITA-RKSSGQG 105
Cdd:pfam01229   1 VKIKVDAARDLRKLTPFWRSCvGFCPPLPALQAD-----WDQQLNLAY----PHIGFEYVRGHgWLLDDITAyRESVDQG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  106 LIYNFTHLDAFLDLLMENQLLPGFEL--------MGSPSGYF--TDFEDKQQVFEWKDLVSLLARRYIGKYGLTNVSKWN 175
Cdd:pfam01229  72 LFYNFTHIDRILDLLLENGLLPFFELgfmpkrlaSGTPTVFFweGNFTPPKQYEEWKNLVSLLARHYIGRYGLDEVSKWN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  176 FETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLRLGGPGDSFHPLPRspmcwSLLGHCANGTnfftgevgVRL 255
Cdd:pfam01229 152 FETWNEPNLKDFDWVDMTEQEYFNLYKACAEAIKEVSPNLKVGGPADSFDPWIR-----SLLEFCYNGN--------VPL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  256 DYISLH---KKGAGSSIAILEQEVAV------VEQIQQLFPKFKDTPIYNDEADPlvGWSLPQPWRADVTYAALVVKVIA 326
Cdd:pfam01229 219 DFISLHaysKKGAGSSILILEEEMASeymlneVKQVRELIPEFPDLPVYNTEANP--SWSPPQPWHDDPTYAAYVVKVIA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  327 QHQNLLFANSSSSMRYILLSNDNAFLSYHpypfsqrtltARFQVNNTHPphvqlLRKPVLTVMGLMALLDGEQLWAEvlk 406
Cdd:pfam01229 297 QHQDLPDANSYWTFRDVFEENDNAFLSFH----------GGFGLNNTHP-----IPKPVLTAFKLLALLDGEQLWAE--- 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  407 agaVLDSNHTVGVLASTHHPEGPSEAWRTTVLIYTSDDTHIHPNDSIPVILHLRGvPPGLELVYVVLYLDNQLSSPYSAW 486
Cdd:pfam01229 359 ---VSDSNHTVGVIASRHDPSGALIAWNEIVLIYSSDDTTAHPDKEYPVTLRLNG-PVGFKLVYIKLMIDEDHGNPWGTW 434

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 285026506  487 QHMGQPVFPSAEQFRQMRMVEDPVAEAPRPFPARGRLT 524
Cdd:pfam01229 435 QHMGRPVFPSKEQIRRLRDAEKPKAEAPRPFPADGRLT 472
XynB COG3664
Beta-xylosidase [Carbohydrate transport and metabolism];
16-539 3.60e-37

Beta-xylosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442881  Cd Length: 490  Bit Score: 145.06  E-value: 3.60e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  16 AFLASPLALAETPYLVRVDAARPLRPLLPFWRSTGfcpplphDQADQY----DLSWDQQLNLAYIGAVPHsgieqVRIHW 91
Cdd:COG3664    4 TLLGPLAAAAPPPVAITVDLAKVAGPMKPLWAWFG-------YDEPNYtymkDGKKLLSEGAGLSPVFRY-----IRFHG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506  92 LL--DLITARKSSGQGLIYNFTHLDAFLDLLMENQLLP----GF---ELMGSPSGYF---------TDFEdkqqvfEWKD 153
Cdd:COG3664   72 LFhdDMGVYREDADGNPVYNFTYVDKIFDFLLELGMKPfvelGFmpeALASGPQTVFwwkgnvtppKDYA------KWAD 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506 154 LVSLLARRYIGKYGLTNVSKWNFETWNEPDHHDFdnVSMTTQGFLNYYDACSEGLRIASPTLRLGGPGDSfhplPRSPMc 233
Cdd:COG3664  146 LVRAFVRHLIDRYGIDEVRSWYFEVWNEPNLSGF--WKGTQEEYFKLYDYTARAVKSVDPRLRVGGPATA----GGAAA- 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506 234 W--SLLGHCAngtnfftgEVGVRLDYISLHKKGAGSSI---------AILEQEVAVVEQIQQlfPKFKDTPIYNDEADpl 302
Cdd:COG3664  219 WlpDFLEHCA--------KNGVPVDFVSTHAYGTDPGFdgqlsmnpdAVLRDVEKVRKLIAA--SAFPNLPLHITEWN-- 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506 303 VGWSLPQPWRADVTYAALVVKVIAQHQNLlfANSsssmryillsndnaflsyhpypFSQRTLTARF--QVNNTHPPH--- 377
Cdd:COG3664  287 TSYTPRDPYHDTAFYAAYIAKSLKRAGDL--ADS----------------------MSYWTFSDIFeeAGPPTQPFHggf 342

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506 378 ----VQLLRKPVLTVMGLMALLDGEQLwaevlkagAVLDSNhtvgVLASThHPEGpseawRTTVLIYTSDDTHIHPNDSi 453
Cdd:COG3664  343 gllnTNGIKKPVYHAFRMLNRLGGERL--------AVGDDD----AVATR-DDDG-----RVAVLVWNYHDDDPAGPAR- 403

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026506 454 PVILHLRGVPPGleLVYVVLY-LDNQLSSPYSAWQHMGQPVFPSAEQFRQMRMVEDPVAEAPRPFPARGRLTLYRKLPVP 532
Cdd:COG3664  404 TVELTLTGLPAG--KYRLTVYrVDEEHGNAYAAWLEMGSPQQPTREQIAELKAAAELQTSPEVVVVADGKLTLDLTLPRN 481


                 ....*..
gi 285026506 533 SLMLVHL 539
Cdd:COG3664  482 SVVLIEL 488
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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