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Conserved domains on  [gi|288541387|ref|NP_001165631|]
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leucine-rich repeat transmembrane protein FLRT3 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-308 3.65e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 3.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  61 TTLYLQNNQINNvgIPSDLKNLLKVQRIYLYHNSLDEFPTNLPKYV--KELHLQENNIRTITyDSLSKIPYLEELHLDDN 138
Cdd:COG4886  116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 139 SVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPGGLPR--TIEELRLDDNRISTIssPSLHGLTSLKRLVLDGNLLNNhgl 216
Cdd:COG4886  193 QITDLPEP---LGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD--- 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 217 gDKVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Cdd:COG4886  265 -LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                        250
                 ....*....|..
gi 288541387 297 ITQLILRNNPWY 308
Cdd:COG4886  344 LSLLALLTLLLL 355
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 277-349 8.70e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.94  E-value: 8.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288541387   277 DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAIKDLS 349
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrQPEAALCAGPGALAGQPLLGIP 74
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-61 4.52e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.46  E-value: 4.52e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 288541387    31 CPSVCRCDAGFIYCNDRSLTSIPVGIPEDAT 61
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 413-478 3.25e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 37.01  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  413 ITVKSVTPDTIHISWRLAL----PMTALRLSWLKLGHSpafGSITETIVTGERSEYLVTALEPESPYRVC 478
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPdgngPITGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVR 72
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-308 3.65e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 3.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  61 TTLYLQNNQINNvgIPSDLKNLLKVQRIYLYHNSLDEFPTNLPKYV--KELHLQENNIRTITyDSLSKIPYLEELHLDDN 138
Cdd:COG4886  116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 139 SVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPGGLPR--TIEELRLDDNRISTIssPSLHGLTSLKRLVLDGNLLNNhgl 216
Cdd:COG4886  193 QITDLPEP---LGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD--- 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 217 gDKVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Cdd:COG4886  265 -LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                        250
                 ....*....|..
gi 288541387 297 ITQLILRNNPWY 308
Cdd:COG4886  344 LSLLALLTLLLL 355
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-306 1.73e-19

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.84  E-value: 1.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  44 CNDR-SLTSIPVGIPEDATTLYLQNNQInnVGIPSDLKNllKVQRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITyd 122
Cdd:PRK15370 184 RLKIlGLTTIPACIPEQITTLILDNNEL--KSLPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSINRITELP-- 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 123 slSKIPY-LEELHLDDNSVSAV--SIEEGafrdsnyLRLLFLSRNHLSTIPGGLPRTIEELRLDDNRISTISSPSLHGlt 199
Cdd:PRK15370 258 --ERLPSaLQSLDLFHNKISCLpeNLPEE-------LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPG-- 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 200 sLKRLVLDGNLLNNhgLGDKVFFNLVNlteLSLVRNSLTAAPVNLPGTsLRKLYLQDNHINRVPPNAFSYLRQlyrLDMS 279
Cdd:PRK15370 327 -LKTLEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI---MQAS 396

                        250       260       270
                 ....*....|....*....|....*....|
gi 288541387 280 NNNLSNLPQGI---FDDLDNITQLILRNNP 306
Cdd:PRK15370 397 RNNLVRLPESLphfRGEGPQPTRIIVEYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-241 1.28e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 1.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  61 TTLYLQNNQINNVGIPSDLKNlLKVqrIYLYHNSLDEFPtNLPKYVK--ELHLQENNIRTItyDSLSKIPYLEELHLDDN 138
Cdd:cd21340    5 THLYLNDKNITKIDNLSLCKN-LKV--LYLYDNKITKIE-NLEFLTNltHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 139 SVSAVsieEGaFRDSNYLRLLFLSRNHLstiPGGL-----PRTIEELR-----LD--DNRISTISspSLHGLTSLKRLVL 206
Cdd:cd21340   79 RISVV---EG-LENLTNLEELHIENQRL---PPGEkltfdPRSLAALSnslrvLNisGNNIDSLE--PLAPLRNLEQLDA 149

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 288541387 207 DGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241
Cdd:cd21340  150 SNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
247-306 2.04e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 2.04e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  247 TSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNP 306
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 277-349 8.70e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.94  E-value: 8.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288541387   277 DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAIKDLS 349
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrQPEAALCAGPGALAGQPLLGIP 74
LRRCT smart00082
Leucine rich repeat C-terminal domain;
305-356 1.01e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.01e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 288541387   305 NPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGmAIKDLSAELFDCK 356
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-61 4.52e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.46  E-value: 4.52e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 288541387    31 CPSVCRCDAGFIYCNDRSLTSIPVGIPEDAT 61
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 31-57 7.39e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.92  E-value: 7.39e-05
                          10        20
                  ....*....|....*....|....*..
gi 288541387   31 CPSVCRCDAGFIYCNDRSLTSIPVGIP 57
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
fn3 pfam00041
Fibronectin type III domain;
413-478 3.25e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.01  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  413 ITVKSVTPDTIHISWRLAL----PMTALRLSWLKLGHSpafGSITETIVTGERSEYLVTALEPESPYRVC 478
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPdgngPITGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVR 72
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-308 3.65e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 3.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  61 TTLYLQNNQINNvgIPSDLKNLLKVQRIYLYHNSLDEFPTNLPKYV--KELHLQENNIRTITyDSLSKIPYLEELHLDDN 138
Cdd:COG4886  116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 139 SVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPGGLPR--TIEELRLDDNRISTIssPSLHGLTSLKRLVLDGNLLNNhgl 216
Cdd:COG4886  193 QITDLPEP---LGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD--- 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 217 gDKVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Cdd:COG4886  265 -LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                        250
                 ....*....|..
gi 288541387 297 ITQLILRNNPWY 308
Cdd:COG4886  344 LSLLALLTLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-305 1.25e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.78  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  45 NDRSLTSIPVGIPEDATTLYLQNNQINNVGIPSDLKNLLKVQRIYLYHNSLDEFPTNLP--KYVKELHLQENNIRTITyD 122
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 123 SLSKIPYLEELHLDDNSVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPGGL--PRTIEELRLDDNRISTISSPsLHGLTS 200
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTN 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 201 LKRLVLDGNLLNNhgLGDkvFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSN 280
Cdd:COG4886  230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                        250       260
                 ....*....|....*....|....*
gi 288541387 281 NNLSNLPQGIFDDLDNITQLILRNN 305
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLL 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-300 2.13e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 2.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  42 IYCNDRSLTSIPVGIPE--DATTLYLQNNQINNvgIPSDLKNLLKVQRIYLYHNSLDEFPT---NLPKyVKELHLQENNI 116
Cdd:COG4886  118 LDLSGNQLTDLPEELANltNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEelgNLTN-LKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 117 RTITyDSLSKIPYLEELHLDDNSVSAVSIEegaFRDSNYLRLLFLSRNHLSTIP--GGLPRtIEELRLDDNRISTIssPS 194
Cdd:COG4886  195 TDLP-EPLGNLTNLEELDLSGNQLTDLPEP---LANLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDL--PP 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 195 LHGLTSLKRLVLDGNLLNNHGLgdKVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLY 274
Cdd:COG4886  268 LANLTNLKTLDLSNNQLTDLKL--KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                        250       260
                 ....*....|....*....|....*.
gi 288541387 275 RLDMSNNNLSNLPQGIFDDLDNITQL 300
Cdd:COG4886  346 LLALLTLLLLLNLLSLLLTLLLTLGL 371
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-306 1.73e-19

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.84  E-value: 1.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  44 CNDR-SLTSIPVGIPEDATTLYLQNNQInnVGIPSDLKNllKVQRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITyd 122
Cdd:PRK15370 184 RLKIlGLTTIPACIPEQITTLILDNNEL--KSLPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSINRITELP-- 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 123 slSKIPY-LEELHLDDNSVSAV--SIEEGafrdsnyLRLLFLSRNHLSTIPGGLPRTIEELRLDDNRISTISSPSLHGlt 199
Cdd:PRK15370 258 --ERLPSaLQSLDLFHNKISCLpeNLPEE-------LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPG-- 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 200 sLKRLVLDGNLLNNhgLGDKVFFNLVNlteLSLVRNSLTAAPVNLPGTsLRKLYLQDNHINRVPPNAFSYLRQlyrLDMS 279
Cdd:PRK15370 327 -LKTLEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI---MQAS 396

                        250       260       270
                 ....*....|....*....|....*....|
gi 288541387 280 NNNLSNLPQGI---FDDLDNITQLILRNNP 306
Cdd:PRK15370 397 RNNLVRLPESLphfRGEGPQPTRIIVEYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-241 1.28e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 1.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  61 TTLYLQNNQINNVGIPSDLKNlLKVqrIYLYHNSLDEFPtNLPKYVK--ELHLQENNIRTItyDSLSKIPYLEELHLDDN 138
Cdd:cd21340    5 THLYLNDKNITKIDNLSLCKN-LKV--LYLYDNKITKIE-NLEFLTNltHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 139 SVSAVsieEGaFRDSNYLRLLFLSRNHLstiPGGL-----PRTIEELR-----LD--DNRISTISspSLHGLTSLKRLVL 206
Cdd:cd21340   79 RISVV---EG-LENLTNLEELHIENQRL---PPGEkltfdPRSLAALSnslrvLNisGNNIDSLE--PLAPLRNLEQLDA 149

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 288541387 207 DGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241
Cdd:cd21340  150 SNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
29-272 6.07e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.12  E-value: 6.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  29 KSCPSVCRCDAGFIYCNDRSLTSIPVGIPEDATTLYLQNNQInnVGIPSDLKNLLkvQRIYLYHNSLDEFPTNLPKYVKE 108
Cdd:PRK15370 212 KSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRI--TELPERLPSAL--QSLDLFHNKISCLPENLPEELRY 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 109 LHLQENNIRTITYDSLSKIpylEELHLDDNSVSAV--SIEEGafrdsnyLRLLFLSRNHLSTIPGGLPRTIEELRLDDNR 186
Cdd:PRK15370 288 LSVYDNSIRTLPAHLPSGI---THLNVQSNSLTALpeTLPPG-------LKTLEAGENALTSLPASLPPELQVLDVSKNQ 357

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 187 ISTIssPSLHGLTslkrlvldgnllnnhglgdkvffnlvnLTELSLVRNSLTAAPVNLPGtSLRKLYLQDNHINRVPPNA 266
Cdd:PRK15370 358 ITVL--PETLPPT---------------------------ITTLDVSRNALTNLPENLPA-ALQIMQASRNNLVRLPESL 407


                 ....*.
gi 288541387 267 FSYLRQ 272
Cdd:PRK15370 408 PHFRGE 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-305 2.97e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 2.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 107 KELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPGGLPRTIEELRlDDNR 186
Cdd:COG4886   22 TTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT-NLTE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 187 ISTISSPSLHGLTSLKRLVLDGNLLNNhgLGDKvFFNLVNLTELSLVRNSLTAAPVNLPG-TSLRKLYLQDNHINRVpPN 265
Cdd:COG4886  101 LDLSGNEELSNLTNLESLDLSGNQLTD--LPEE-LANLTNLKELDLSNNQLTDLPEPLGNlTNLKSLDLSNNQLTDL-PE 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 288541387 266 AFSYLRQLYRLDMSNNNLSNLPQGIFdDLDNITQLILRNN 305
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGN 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 109-306 1.00e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 1.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 109 LHLQENNIRTItyDSLSKIPYLEELHLDDNSVSavSIE--EGAFRdsnyLRLLFLSRNHLSTIPG--GLPRtIEELRLDD 184
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKIT--KIEnlEFLTN----LTHLYLQNNQIEKIENleNLVN-LKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 185 NRISTISSpsLHGLTSLKRLVLDGNLLnnhGLGDKVFFNLVNLTELSlvrnsltaapvnlpgTSLRKLYLQDNHINRVPP 264
Cdd:cd21340   78 NRISVVEG--LENLTNLEELHIENQRL---PPGEKLTFDPRSLAALS---------------NSLRVLNISGNNIDSLEP 137

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 288541387 265 naFSYLRQLYRLDMSNNNLSNLPQ--GIFDDLDNITQLILRNNP 306
Cdd:cd21340  138 --LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-305 1.49e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 1.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 106 VKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAvSIEEGAFRDSNYLRLLFLSRNHLS-TIPGGLPRTIEELRLDD 184
Cdd:PLN00113  71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSN 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 185 NRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGDkvFFNLVNLTELSLVRNSLTAA-PVNLPGT-SLRKLYLQDNHINRV 262
Cdd:PLN00113 150 NMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNS--LTNLTSLEFLTLASNQLVGQiPRELGQMkSLKWIYLGYNNLSGE 227

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 288541387 263 PPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Cdd:PLN00113 228 IPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270
LRR_8 pfam13855
Leucine rich repeat;
247-306 2.04e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 2.04e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  247 TSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNP 306
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-230 8.56e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 8.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  61 TTLYLQNNQInnvgipSDLKNLlkvqriylyhNSLdefpTNLpkyvKELHLQENNIRTITydSLSKIPYLEELHL----- 135
Cdd:cd21340   49 THLYLQNNQI------EKIENL----------ENL----VNL----KKLYLGGNRISVVE--GLENLTNLEELHIenqrl 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 136 --------DDNSVSAVsieegafrdSNYLRLLFLSRNHLSTIPG--GLPRtIEELRLDDNRISTIS--SPSLHGLTSLKR 203
Cdd:cd21340  103 ppgekltfDPRSLAAL---------SNSLRVLNISGNNIDSLEPlaPLRN-LEQLDASNNQISDLEelLDLLSSWPSLRE 172

                        170       180
                 ....*....|....*....|....*...
gi 288541387 204 LVLDGN-LLNNHGLGDKVFFNLVNLTEL 230
Cdd:cd21340  173 LDLTGNpVCKKPKYRDKIILASKSLEVL 200
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-232 1.95e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  42 IYCNDRSLTSIPVGI--PEDATTLYLQNNQINNvgIPSDLKNLLKVQRIYLYHNSLDEFP--TNLPKyVKELHLQENNIR 117
Cdd:COG4886  187 LDLSNNQITDLPEPLgnLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLT 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 118 TItyDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPGGLPRTIEELRLDDNRISTISSPSLHG 197
Cdd:COG4886  264 DL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 288541387 198 LTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSL 232
Cdd:COG4886  342 LSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-284 7.62e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 7.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  75 IPSDLKNLLKVQRIYLYHNSLDEfptNLPKyvkelhlqennirtitydSLSKIPYLEELHLDDNSVSAvSIEEGAFRDSN 154
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSG---PIPP------------------SIFSLQKLISLDLSDNSLSG-EIPELVIQLQN 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 155 yLRLLFLSRNHLS-TIPGG---LPRtIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNnhGLGDKVFFNLVNLTEL 230
Cdd:PLN00113 310 -LEILHLFSNNFTgKIPVAltsLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLT--GEIPEGLCSSGNLFKL 385

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 288541387 231 SLVRNSLTAA-PVNLPG-TSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLS 284
Cdd:PLN00113 386 ILFSNSLEGEiPKSLGAcRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ 441
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 277-349 8.70e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.94  E-value: 8.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288541387   277 DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAIKDLS 349
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrQPEAALCAGPGALAGQPLLGIP 74
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-327 9.75e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 57.37  E-value: 9.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 107 KELHLQENNIR--TITYDSLSKI-------PYLEELHLDDN----SVSAVSIEEGAFRDSNYLRLLFLSRNHLS-TIPGG 172
Cdd:cd00116   21 KLLCLQVLRLEgnTLGEEAAKALasalrpqPSLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGpDGCGV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 173 LPR-----TIEELRLDDNRISTISSPSL-HGLTS----LKRLVLDGNLLNNHGLGD--KVFFNLVNLTELSLVRNSLTAA 240
Cdd:cd00116  101 LESllrssSLQELKLNNNGLGDRGLRLLaKGLKDlppaLEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 241 --PVNLPG----TSLRKLYLQDNHINRVPPNA----FSYLRQLYRLDMSNNNLSNLP-QGIFDDLDNITQLILRNNPWYC 309
Cdd:cd00116  181 giRALAEGlkanCNLEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCN 260

                        250
                 ....*....|....*...
gi 288541387 310 GCKMKWVRDWLQSLPVKV 327
Cdd:cd00116  261 DITDDGAKDLAEVLAEKE 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
177-306 1.94e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 1.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 177 IEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVR-----------------NSLTA 239
Cdd:COG4886   48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGneelsnltnlesldlsgNQLTD 127

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288541387 240 APVNLPG-TSLRKLYLQDNHINRVPPnAFSYLRQLYRLDMSNNNLSNLPQGIfDDLDNITQLILRNNP 306
Cdd:COG4886  128 LPEELANlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193
LRRCT smart00082
Leucine rich repeat C-terminal domain;
305-356 1.01e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.01e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 288541387   305 NPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGmAIKDLSAELFDCK 356
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
226-283 1.30e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288541387  226 NLTELSLVRNSLTA----APVNLPgtSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL 283
Cdd:pfam13855   2 NLRSLDLSNNRLTSlddgAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
140-305 1.57e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 140 VSAVSIEEGAFRDSNYLRL----------LFLSRNHLSTIPGGLPRTIEELRLDDNRISTISSpSLHGltSLKRLVLDGN 209
Cdd:PRK15370 154 VKEAPAKEAANREEAVQRMrdclknnkteLRLKILGLTTIPACIPEQITTLILDNNELKSLPE-NLQG--NIKTLYANSN 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 210 LLNN--HGLGDKVffnlvnlTELSLVRNSLTAAPVNLPgTSLRKLYLQDNHINRVPPNAFSYLRQlyrLDMSNNNLSNLP 287
Cdd:PRK15370 231 QLTSipATLPDTI-------QEMELSINRITELPERLP-SALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTLP 299

                        170
                 ....*....|....*...
gi 288541387 288 QGIfddLDNITQLILRNN 305
Cdd:PRK15370 300 AHL---PSGITHLNVQSN 314
LRR_8 pfam13855
Leucine rich repeat;
175-237 1.70e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.70e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288541387  175 RTIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNnhGLGDKVFFNLVNLTELSLVRNSL 237
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
128-211 2.47e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  128 PYLEELHLDDNSVSavSIEEGAFRDSNYLRLLFLSRNHLSTIPGGlprtieelrlddnristisspSLHGLTSLKRLVLD 207
Cdd:pfam13855   1 PNLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPG---------------------AFSGLPSLRYLDLS 57


                  ....
gi 288541387  208 GNLL 211
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-284 6.75e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 6.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  55 GIPEDA------TTLYLQNNQINNvGIPSDLKNLLKVQRIYLYHNSLD-EFPTNLP--KYVKELHLQENNIRTITYDSLS 125
Cdd:PLN00113 347 EIPKNLgkhnnlTVLDLSTNNLTG-EIPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFT 425

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 126 KIPYLEELHLDDNSVSAvSIEEGAFrDSNYLRLLFLSRNHLStipGGLP-----RTIEELRLDDNRISTISSPSLHGLTS 200
Cdd:PLN00113 426 KLPLVYFLDISNNNLQG-RINSRKW-DMPSLQMLSLARNKFF---GGLPdsfgsKRLENLDLSRNQFSGAVPRKLGSLSE 500

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 201 LKRLVLDGNLLNNhglgdkvffnlVNLTELSLVRNsltaapvnlpgtsLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSN 280
Cdd:PLN00113 501 LMQLKLSENKLSG-----------EIPDELSSCKK-------------LVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQ 556


                 ....
gi 288541387 281 NNLS 284
Cdd:PLN00113 557 NQLS 560
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-305 8.01e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 8.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  46 DRSLTSIPVGIPEdaTTLYLQNNQI-----NNV--GIPSDLKNLLKVQRIYLYHNSLD-EFPTNLPKY--VKELHLQENN 115
Cdd:PLN00113 290 DLSDNSLSGEIPE--LVIQLQNLEIlhlfsNNFtgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHnnLTVLDLSTNN 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 116 IRTITYDSLSKIPYLEELHLDDNSVsavsieEG----AFRDSNYLRLLFLSRNHLStipGGLPRTIEELRL-------DD 184
Cdd:PLN00113 368 LTGEIPEGLCSSGNLFKLILFSNSL------EGeipkSLGACRSLRRVRLQDNSFS---GELPSEFTKLPLvyfldisNN 438

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 185 NRISTISS-----PSLHGLtSLKRLVLDGNLLNnhglgdkvFFNLVNLTELSLVRNSLTAA-PVNLPGTS-LRKLYLQDN 257
Cdd:PLN00113 439 NLQGRINSrkwdmPSLQML-SLARNKFFGGLPD--------SFGSKRLENLDLSRNQFSGAvPRKLGSLSeLMQLKLSEN 509

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 288541387 258 HINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Cdd:PLN00113 510 KLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-61 4.52e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.46  E-value: 4.52e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 288541387    31 CPSVCRCDAGFIYCNDRSLTSIPVGIPEDAT 61
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
46-306 9.64e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.01  E-value: 9.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  46 DRSLTSIPVGIPEDATTLYLQNNQINNV-GIPSDLKNL---------LKV-----QRIYLYHNSLDEFPTnLPKYVKELH 110
Cdd:PRK15387 210 ESGLTTLPDCLPAHITTLVIPDNNLTSLpALPPELRTLevsgnqltsLPVlppglLELSIFSNPLTHLPA-LPSGLCKLW 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 111 LQENNIRTITYDSlskiPYLEELHLDDNSVSAVSIEegafrdSNYLRLLFLSRNHLSTIPgGLPRTIEELRLDDNRISTI 190
Cdd:PRK15387 289 IFGNQLTSLPVLP----PGLQELSVSDNQLASLPAL------PSELCKLWAYNNQLTSLP-TLPSGLQELSVSDNQLASL 357

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 191 ssPSLHglTSLKRLVLDGNLLNNHGLGDKvffnlvNLTELSLVRNSLTAAPVnLPgTSLRKLYLQDNHINRVP--PNAfs 268
Cdd:PRK15387 358 --PTLP--SELYKLWAYNNRLTSLPALPS------GLKELIVSGNRLTSLPV-LP-SELKELMVSGNRLTSLPmlPSG-- 423

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 288541387 269 ylrqLYRLDMSNNNLSNLPQGIFdDLDNITQLILRNNP 306
Cdd:PRK15387 424 ----LLSLSVYRNQLTRLPESLI-HLSSETTVNLEGNP 456
LRR_8 pfam13855
Leucine rich repeat;
106-166 3.11e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.11e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541387  106 VKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSavSIEEGAFRDSNYLRLLFLSRNHL 166
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 31-57 7.39e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.92  E-value: 7.39e-05
                          10        20
                  ....*....|....*....|....*..
gi 288541387   31 CPSVCRCDAGFIYCNDRSLTSIPVGIP 57
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 226-305 5.89e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 226 NLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPpnAFSYLRQLYRLDMSNNNLSNLPQgiFDDLDNITQLILRNN 305
Cdd:cd21340    3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 61-259 2.18e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  61 TTLYLQNNQINNVGIPSDLKNLLKVQRIY---LYHNSL-DEFPTNLPKYVKE------LHLQENNIRTITYDSLSK---- 126
Cdd:COG5238  211 TTLWLKRNPIGDEGAEILAEALKGNKSLTtldLSNNQIgDEGVIALAEALKNnttvetLYLSGNQIGAEGAIALAKalqg 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387 127 IPYLEELHLDDNSV---SAVSIEEGaFRDSNYLRLLFLSRNHLSTiPGGLP--------RTIEELRLDDNRISTISSPSL 195
Cdd:COG5238  291 NTTLTSLDLSVNRIgdeGAIALAEG-LQGNKTLHTLNLAYNGIGA-QGAIAlakalqenTTLHSLDLSDNQIGDEGAIAL 368

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288541387 196 hgltslkrlvldGNLLNNHGlgdkvffnlvNLTELSLVRNSLTAAPVN-----LPGTSLRKLYLQDNHI 259
Cdd:COG5238  369 ------------AKYLEGNT----------TLRELNLGKNNIGKQGAEalidaLQTNRLHTLILDGNLI 415
LRR_8 pfam13855
Leucine rich repeat;
84-138 2.90e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 288541387   84 KVQRIYLYHNSL----DEFPTNLPKyVKELHLQENNIRTITYDSLSKIPYLEELHLDDN 138
Cdd:pfam13855   2 NLRSLDLSNNRLtsldDGAFKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
fn3 pfam00041
Fibronectin type III domain;
413-478 3.25e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.01  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541387  413 ITVKSVTPDTIHISWRLAL----PMTALRLSWLKLGHSpafGSITETIVTGERSEYLVTALEPESPYRVC 478
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPdgngPITGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVR 72
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 247-283 9.03e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 9.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 288541387  247 TSLRKLYLQDNHINRVPPnaFSYLRQLYRLDMSNNNL 283
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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