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Conserved domains on  [gi|288557345|ref|NP_001165694|]
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MOB kinase activator 2 isoform 1 [Homo sapiens]

Protein Classification

Mob1/phocein family protein( domain architecture ID 10508319)

Mob1/phocein family protein similar to Saccharomyces cerevisiae maintenance of ploidy protein MOB1 that functions as an activator subunit for the DBF2 protein kinase

CATH:  1.20.140.30
Gene Ontology:  GO:0030295
SCOP:  4000646

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mob1_phocein pfam03637
Mob1/phocein family; Mob1 is an essential Saccharomyces cerevisiae protein, identified from a ...
 63-231 5.47e-89

Mob1/phocein family; Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.


:

Pssm-ID: 461000  Cd Length: 171  Bit Score: 261.32  E-value: 5.47e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557345   63 KARITDFQFKELVVLPREIDLNEWLASNTTTFFHHINLQYSTISEFCTGETCQTM-AVCNTQYYWYDER-GKKVKCTAPQ 140
Cdd:pfam03637   1 KATLGSGDLKTAVKLPKGEDLNEWLAVHTVDFFNEINLLYGTISEFCTPETCPTMsAGPQYEYLWADGKyKKPTKLSAPQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557345  141 YVDFVMSSVQKLVTDEDVFPTKYGREFPSSFESLVRKICRHLFHVLAHIYWAHFKETLALELHGHLNTLYVHFILFAREF 220
Cdd:pfam03637  81 YIDYLMTWIQSQLNDEKIFPTKVGVPFPKNFLSIVKKIFRRLFRVYAHIYHHHFEEIVELGLEAHLNTCFKHFVLFVREF 160

                         170
                  ....*....|.
gi 288557345  221 NLLDPKETAIM 231
Cdd:pfam03637 161 DLLDKKELEPL 171
 
Name Accession Description Interval E-value
Mob1_phocein pfam03637
Mob1/phocein family; Mob1 is an essential Saccharomyces cerevisiae protein, identified from a ...
 63-231 5.47e-89

Mob1/phocein family; Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.


Pssm-ID: 461000  Cd Length: 171  Bit Score: 261.32  E-value: 5.47e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557345   63 KARITDFQFKELVVLPREIDLNEWLASNTTTFFHHINLQYSTISEFCTGETCQTM-AVCNTQYYWYDER-GKKVKCTAPQ 140
Cdd:pfam03637   1 KATLGSGDLKTAVKLPKGEDLNEWLAVHTVDFFNEINLLYGTISEFCTPETCPTMsAGPQYEYLWADGKyKKPTKLSAPQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557345  141 YVDFVMSSVQKLVTDEDVFPTKYGREFPSSFESLVRKICRHLFHVLAHIYWAHFKETLALELHGHLNTLYVHFILFAREF 220
Cdd:pfam03637  81 YIDYLMTWIQSQLNDEKIFPTKVGVPFPKNFLSIVKKIFRRLFRVYAHIYHHHFEEIVELGLEAHLNTCFKHFVLFVREF 160

                         170
                  ....*....|.
gi 288557345  221 NLLDPKETAIM 231
Cdd:pfam03637 161 DLLDKKELEPL 171
 
Name Accession Description Interval E-value
Mob1_phocein pfam03637
Mob1/phocein family; Mob1 is an essential Saccharomyces cerevisiae protein, identified from a ...
 63-231 5.47e-89

Mob1/phocein family; Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.


Pssm-ID: 461000  Cd Length: 171  Bit Score: 261.32  E-value: 5.47e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557345   63 KARITDFQFKELVVLPREIDLNEWLASNTTTFFHHINLQYSTISEFCTGETCQTM-AVCNTQYYWYDER-GKKVKCTAPQ 140
Cdd:pfam03637   1 KATLGSGDLKTAVKLPKGEDLNEWLAVHTVDFFNEINLLYGTISEFCTPETCPTMsAGPQYEYLWADGKyKKPTKLSAPQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557345  141 YVDFVMSSVQKLVTDEDVFPTKYGREFPSSFESLVRKICRHLFHVLAHIYWAHFKETLALELHGHLNTLYVHFILFAREF 220
Cdd:pfam03637  81 YIDYLMTWIQSQLNDEKIFPTKVGVPFPKNFLSIVKKIFRRLFRVYAHIYHHHFEEIVELGLEAHLNTCFKHFVLFVREF 160

                         170
                  ....*....|.
gi 288557345  221 NLLDPKETAIM 231
Cdd:pfam03637 161 DLLDKKELEPL 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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